Advanced Course on Bioinformatics and Comparative Genome Analysis

Fredj TekaiaInstitut Pasteur

tekaia@pasteur.fr

Introduction

Advanced Course on Bioinformatics and Comparative Genome Analysis

June 30 - July 12, 2008

Universidade Federal de Santa Catarina, Florianopolis, Brazil

Organizers/Contact:

Course web page: http://www.pasteur.fr/~tekaia/ACBCGA.html

• Alberto M.R. Davila, Instituto Oswaldo Cruz, FIOCRUZ, Rio, Brazil;

• Edmundo Grisard, Universidade Federal de Santa Catarina, Florianopolis, Brazil;

• Hugo Naya, Institut Pasteur Montevideo, Uruguay;

• Fredj Tekaia, Institut Pasteur Paris, France.

Financial support

CNPq/QUADTRYP/FINEP

Why this course ?

672 53

94

http://www.genomesonline.org/

Tree of life

Complete genomes 3823 projects • 819 published (12-06-08)• 1848 Bacteria• 90 Archaea• 936 eukaryotes• 130 metagenomes

• 3 phylogenetic domains;• Lifestyles: mesophiles; (hyper)thermophiles; psychrophiles; extreme conditions,...

Number of available completely sequenced genomes

GOLDList and references

Completely sequenced Genomes that span the three domains of life are growing at a rapid rate

06-2008

2 5 12 19 24 4271

116165

224

323

471

700

819

050

100150200250300350400450500550600650700750800850900

95 96 97 98 99 00 01 02 03 04 05 06 07 08

Years

Number of complete genomes

3823 projects

Genome studies show that:

• Access to entire genome sequences is revolutionizing our understanding of how genetic information is stored and organized in DNA, and how it has evolved over time.

• The sequence of a genome provides significant details of the gene catalogue within a species.

• Comparisons of complete genome sequences show the acceleration in the understanding of species organisation, links between genes, functions of the genes, evolution of genes, genomes and species.

=> Beyond fundamental biological and methodological interests, Expected applications include: Drug, Medical and Agricultural,… discoveries.

• Few scientists are involved in generating data and much more are involved in data analyses

Genomics

Is the study of genomes.

(including the study of their genes, proteins, their sequences, functions, evolution,....)

Bioinformatics is needed to transform the flood of raw data (sequences) into scientific knowledge.

Mathematics Statistics

Nucleotide & protein sequences and related

informations

InformaticsBiology

Bioinformatics

The main objectives of the course are to familiarize you with bioinformatics and

large scalegenome data analyses skills by introducing:

1- advanced fundamental algorithms in Bioinformatics;

2- their application in genome analyses;

3- recent knowledge acquired from genomes studies and their perspectives.

Bioinformatics and Comparative Genome Analysis

• We hope that this course will motivate some of you to continue their involvement in these fascinating domains:

Bioinformatics and Genomics.

Enjoy

this exiting program

and

your stay in Florianopolis.