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Adrenergic Receptor 

Adrenergic receptors are a class of G protein-coupled receptors thatare targets of the catecholamines, especially norepinephrine andepinephrine. Many cells possess these receptors, and the binding of acatecholamine to the receptor will generally stimulate thesympathetic nervous system. The sympathetic nervous system isresponsible for the fight-or-flight response, which includes wideningthe pupils of the eye, mobilizing energy, and diverting blood flowfrom non-essential organs to skeletal muscle. There are two maingroups of adrenergic receptors, α and β, with several subtypes. αreceptors have the subtypes α1 and α2. β receptors have thesubtypes β1, β2 and β3. All three are linked to Gs proteins, which in

turn are linked to adenylate cyclase. Agonist binding thus causes a rise in the intracellular concentration of the secondmessenger cAMP. Downstream effectors of cAMP include cAMP-dependent protein kinase (PKA), which mediatessome of the intracellular events following hormone binding.

Purity: 98.79%Clinical Data:Size: 10mM x 1mL in DMSO,

100 mg, 500 mg, 1 g

Purity: >98%Clinical Data:Size: 10 mg, 50 mg

Purity: 99.88%Clinical Data:Size: 10mM x 1mL in DMSO,

10 mg, 50 mg

Purity: >98.0%Clinical Data:Size: 10mM x 1mL in DMSO,

100 mg

Purity: 99.64%Clinical Data:Size: 10mM x 1mL in DMSO,

5 mg, 10 mg, 50 mg, 100 mg

Purity: 99.98%Clinical Data:Size: 10mM x 1mL in DMSO,

100 mg, 5 g, 10 g

Purity: 98.41%Clinical Data:Size: 10mM x 1mL in DMSO,

100 mg, 200 mg, 500 mg

Purity: 98.89%Clinical Data: Phase 4Size: 10mM x 1mL in DMSO,

100 mg, 200 mg

Purity: 99.4%Clinical Data:Size: 10mM x 1mL in DMSO,

100 mg, 500 mg

Purity: >98%Clinical Data:Size: 200 mg

Adrenergic Receptor Inhibitors & Modulators

Bioactivity: (R)-(-)-Phenylephrine is a selective agonistα -adrenoceptor1primarily used as a decongestant.

Bioactivity: (R)-(-)-Phenylephrine hydrochloride is a phenylephrine (PE) and anα1-adrenoceptor agonist

Bioactivity: (S)-Timolol maleate, is a potent non-selective β-adrenergic receptorantagonist (Ki values are 1.97 and 2.0 nM for β1 and β2 receptorsubtypes respectively).

Bioactivity: Bisoprolol is a selective type β1 adrenergic receptor blocker.

Bioactivity: Acebutolol Hydrochloride is a β-adrenergic receptors antagonistused in the treatment of hypertension, angina pectoris and cardiacarrhythmias.

Bioactivity: Adrafinil (CRL-40028, Olmifon), prodrug of modafinil, is a mild centralnervous system stimulant drug used to relieve excessive sleepinessand inattention, Adrafinil is believed to serve as an alpha-1adrenoceptor agonist.

Bioactivity: Adrenalone hydrochloride is a selective α1-adrenoceptor agonist,used as a topical vasoconstrictor and hemostatic, used to prolongthe action of local anesthetics.

Bioactivity: Alfuzosin is an α1 adrenergic receptor antagonist used to treatbenign prostatic hyperplasia (BPH).

Bioactivity: Alfuzosin hydrochloride is an α1 adrenergic receptor antagonist usedto treat benign prostatic hyperplasia (BPH).

Bioactivity: Amezinium metilsulfate has multiple mechanisms, includingstimulation of alpha and beta-1 receptors and inhibitionofnoradrenaline and tyramine uptake.

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(R)-(-)-Phenylephrine(Phenylephrine) Cat. No.: HY-B0769

(R)-(-)-Phenylephrine (hydrochloride)(Phenylephrine hydrochloride) Cat. No.: HY-B0471

(S)-Timolol (Maleate)(Timolol Maleate) Cat. No.: HY-17380

(±)-Bisoprolol (hemifumarate)(Bisoprolol hemifumarate salt) Cat. No.: HY-B0076

Acebutolol (hydrochloride)Cat. No.: HY-17497A

Adrafinil(CRL 40028) Cat. No.: HY-17549

Adrenalone (hydrochloride)Cat. No.: HY-B1308

Alfuzosin(SL 77499) Cat. No.: HY-B0192

Alfuzosin (hydrochloride)(SL 77499-10) Cat. No.: HY-B0192A

Amezinium (methylsulfate)(Amezinium metilsulfate; Lu-1631) Cat. No.: HY-A0275

www.MedChemExpress.com 3

Purity: >98%Clinical Data: Phase 2Size: 10mM x 1mL in DMSO,

5 mg, 10 mg, 50 mg, 100 mg

Purity: 99.8%Clinical Data:Size: 10mM x 1mL in DMSO,

10 mg, 50 mg, 100 mg

Purity: >98%Clinical Data:Size: 10 mg, 50 mg, 100 mg

Purity: 99.93%Clinical Data:Size: 10mM x 1mL in DMSO,

10 mg, 50 mg, 100 mg

Purity: 99.64%Clinical Data:Size: 10mM x 1mL in DMSO,

10 mg, 50 mg

Purity: 99.07%Clinical Data:Size: 10mM x 1mL in DMSO,

10 mg, 50 mg

Purity: >98.0%Clinical Data:Size: 10mM x 1mL in DMSO,

1 g, 5 g

Purity: 99.94%Clinical Data: Phase 4Size: 10mM x 1mL in DMSO,

10 mg, 50 mg, 100 mg, 200 mg, 500 mg

Purity: >98%Clinical Data: Phase 4Size: 10mM x 1mL in DMSO,

10 mg, 50 mg, 100 mg

Purity: >98%Clinical Data:Size: 100 mg

 

Bioactivity: Amitraz is a non-systemic acaricide and insecticide, withalpha-adrenergic agonist activity, interaction with octopaminereceptors of the central nervous system and inhibition of monoamineoxidases and prostaglandin synthesis.

Bioactivity: Asenapine(Org 5222) inhibits adrenergic receptor (α1, α2A, α2B, α2C)with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B,2C, 5A, 6, 7) with Ki of 0.03-4.0 nM.

Bioactivity: Asenapine maleate(Org 5222 maleate) inhibits adrenergic receptor(α1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HTreceptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM.

Bioactivity: Atenolol is a selective β1 receptor antagonist.

Bioactivity: Atipamezole(MPV1248) is an alpha-adrenoceptor antagonist withhigh affinity and selectivity for the alpha 2-receptor.

Bioactivity: Atipamezole Hcl(MPV1248 Hcl) is an alpha-adrenoceptor antagonistwith high affinity and selectivity for the alpha 2-receptor.

Bioactivity: B-HT 920(Talipexole 2Hcl) is a dopamine D2 receptor agonist,α2-adrenoceptor agonist and 5-HT3 receptor antagonist, whichdisplays antiParkinsonian activity.

Bioactivity: Bambuterol is a long acting beta-adrenoceptor agonist (LABA) usedin the treatment of asthma; it also is a prodrug of terbutaline.

Bioactivity: Bambuterol Hcl is a long acting beta-adrenoceptor agonist (LABA)used in the treatment of asthma; it also is a prodrug of terbutaline.

Bioactivity: Batefenterol (GSK961081;TD-5959) is a novel receptormuscarinicantagonist and agonist; displays high affinity forβ -adrenoceptor2hM2, hM3 muscarinic and hβ -adrenoceptor with values of 1.4, 1.32 Kiand 3.7 nM, respectively.

Amitraz(BTS-27419) Cat. No.: HY-B1111

Asenapine(Org 5222; Org-5222; Org5222) Cat. No.: HY-10121

Asenapine (maleate) (Org 5222 maleate; Org-5222 maleate; Or

g5222 maleate) Cat. No.: HY-11100

Atenolol((RS)-Atenolol) Cat. No.: HY-17498

Atipamezole(MPV-1248; MPV1248; MPV 1248) Cat. No.: HY-12380A

Atipamezole (hydrochloride) (MPV-1248 hydrochloride; MP

V1248 hydrochloride; MPV 1248 hydrochloride) Cat. No.: HY-12380

B-HT 920(Talipexole dihydrochloride) Cat. No.: HY-A0008

Bambuterol((±)-Bambuterol) Cat. No.: HY-17501

Bambuterol (hydrochloride)(KWD-2183; (±)-Bambuterol hydrochloride) Cat. No.: HY-17501A

Batefenterol(GSK961081; TD-5959) Cat. No.: HY-12980

Purity: 99.87%Clinical Data:Size: 10mM x 1mL in DMSO,

5 mg, 10 mg, 50 mg

Purity: 99.08%Clinical Data:Size: 10mM x 1mL in DMSO,

50 mg, 100 mg

Purity: >98%Clinical Data:Size: 25 mg, 100 mg

Purity: 99.87%Clinical Data:Size: 10mM x 1mL in DMSO,

5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Purity: 99.95%Clinical Data:Size: 10mM x 1mL in DMSO,

100 mg, 500 mg

Purity: >98%Clinical Data:Size: 100 mg, 500 mg

Purity: 99.92%Clinical Data: Phase 4Size: 10mM x 1mL in DMSO,

100 mg, 500 mg

Purity: 99.88%Clinical Data:Size: 10mM x 1mL in DMSO,

50 mg, 100 mg

Purity: 98.63%Clinical Data:Size: 10mM x 1mL in DMSO,

10 mg, 50 mg, 100 mg

Purity: 98.06%Clinical Data:Size: 10mM x 1mL in DMSO,

10 mg, 50 mg, 100 mg

 

Bioactivity: Betaxolol is a selective beta1 adrenergic receptor blocker used in thetreatment of hypertension and glaucoma.

Bioactivity: Betaxolol Hydrochloride is a selective beta1 adrenergic receptorblocker used in the treatment of hypertension and glaucoma.

Bioactivity: Carteolol HCl is a non-selective beta blocker used to treat glaucoma. Bioactivity: Carvedilol(BM14190) is a non-selective beta blocker/alpha-1 blockerwith an IC50 of 3.8 μM for inhibition of LDL oxidation.

Bioactivity: Carvedilol is a non-selective beta blocker/alpha-1 blocker with anIC50 of 3.8 μM for inhibition of LDL oxidation.

Bioactivity: Clonidine Hydrochloride is a centrally acting alpha-agonisthypotensive agent.

Bioactivity: Dapiprazole hydrochloride is a potent α-adrenergic blocking drug,which is used to reverse mydriasis after eye examination.

Bioactivity: Detomidine produce dose-dependent sedative and analgesic effects,is a nonnarcotic, synthetic α2-adrenergic agonist

Bioactivity: Detomidine hydrochloride produce dose-dependent sedative andanalgesic effects, is a nonnarcotic, synthetic α2-adrenergic agonist

Bioactivity: Dexmedetomidine Hydrochloride is an agonist of adrenergic alpha-2receptor, which is used in veterinary medicine for its analgesic andsedative properties

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BetaxololCat. No.: HY-B0381

Betaxolol (hydrochloride)(SL75212) Cat. No.: HY-B0381A

Carteolol (hydrochloride)Cat. No.: HY-17495A

Carvedilol(BM 14190; BM-14190; BM14190) Cat. No.: HY-B0006

Carvedilol (phosphate hemihydrate)Cat. No.: HY-B0006A

Clonidine (hydrochloride)Cat. No.: HY-B0409A

Dapiprazole (hydrochloride)Cat. No.: HY-A0142A

DetomidineCat. No.: HY-B0163

Detomidine (hydrochloride)Cat. No.: HY-B0163A

Dexmedetomidine (hydrochloride) ((+)-Medetomidine hydrochlo

ride; (S)-Medetomidine hydrochloride) Cat. No.: HY-17034A

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Purity: >98%Clinical Data: Phase 4Size: 10 mg, 50 mg

Purity: >98%Clinical Data:Size: 10mM x 1mL in DMSO,

5 g

Purity: 99.71%Clinical Data:Size: 10mM x 1mL in DMSO,

100 mg

Purity: >98%Clinical Data:Size: 100 mg

Purity: 99.25%Clinical Data:Size: 10mM x 1mL in DMSO,

10 mg, 50 mg, 100 mg

Purity: 99.6%Clinical Data:Size: 10mM x 1mL in DMSO,

5 mg, 10 mg

Purity: 99.36%Clinical Data:Size: 10mM x 1mL in DMSO,

1 g, 5 g

Purity: >98%Clinical Data:Size: 100 mg, 500 mg

Purity: 99.78%Clinical Data:Size: 10mM x 1mL in DMSO,

100 mg

Purity: 99.5%Clinical Data:Size: 10mM x 1mL in DMSO,

1 g, 5 g

 

Bioactivity: DL-Epinephrine(DL-Adrenaline) is a hormone and a neurotransmitter. Bioactivity: Dobutamine Hcl(Dobutrex) is a sympathomimetic drug used in thetreatment of heart failure and cardiogenic shock. Its primarymechanism is direct stimulation of β1 receptors of the sympatheticnervous system.

Bioactivity: Doxazosin(UK 33274) is a quinazoline-derivative that selectivelyantagonizes postsynaptic α1-adrenergic receptors.

Bioactivity: Doxazosin mesylate(UK 33274) is a quinazoline-derivative thatselectively antagonizes postsynaptic α1-adrenergic receptors

Bioactivity: Epiberberine chloride, a natural alkaloid, is a inhibitor, whichBACE1also exhibits inhibition activity on CYP2D6 and aldose reductase,alpha-adrenoceptors, acetylcholinesterase (AChE),butyrylcholinesterase, and b-site amyloid precursor protein cleavingenzyme 1.

Bioactivity: Esmolol Hydrochloride is a beta adrenergic receptor blocker

Bioactivity: Fenoterol is a β 2 adrenergic agonist designed to open up theairways to the lungs, is classed as sympathomimetic β2 agonist andasthma medication.

Bioactivity: Fenoterol hydrobromide is a β 2 adrenergic agonist designed toopen up the airways to the lungs, is classed as sympathomimetic β2agonist and asthma medication.

Bioactivity: Fenspiride Hcl is an α adrenergic and H1 histamine receptorantagonist.

Bioactivity: Formoterol(Arformoterol) is a novel highly β2-selective adrenergicagonist and holds promise as a β2-agonist that could impartselective beneficial metabolic effects.

DL-Epinephrine((±)-Epinephrine; (±)-Adrenaline; DL-Adrenaline) Cat. No.: HY-B0447

Dobutamine (hydrochloride)Cat. No.: HY-15746

Doxazosin(UK 33274) Cat. No.: HY-B0098

Doxazosin (mesylate)(UK 33274 mesylate) Cat. No.: HY-B0098A

Epiberberine (chloride)Cat. No.: HY-N0226A

Esmolol (hydrochloride)Cat. No.: HY-B1392

Fenoterol(Th-1165; Phenoterol) Cat. No.: HY-B0976

Fenoterol (hydrobromide) (Fenoterol bromide; Th-1165a; Phenotero

l hydrobromide) Cat. No.: HY-B0976A

Fenspiride (Hydrochloride)Cat. No.: HY-A0027

Formoterol((-)-Formoterol; Arformoterol; (R,R)-Formoterol) Cat. No.: HY-B0010A

Purity: >98%Clinical Data:Size: 1 mg, 5 mg

Purity: 99.59%Clinical Data:Size: 10mM x 1mL in DMSO,

100 mg, 500 mg

Purity: >98%Clinical Data: Phase 4Size: 10mM x 1mL in DMSO,

100 mg, 500 mg

Purity: 99%Clinical Data:Size: 10mM x 1mL in DMSO,

10 mg, 50 mg, 100 mg

Purity: >98%Clinical Data:Size: 200 mg, 500 mg

Purity: >98%Clinical Data:Size: 10mM x 1mL in DMSO,

5 mg, 25 mg

Purity: 99.88%Clinical Data: Phase 3, Phase 4Size: 10mM x 1mL in DMSO,

10 mg, 50 mg, 100 mg

Purity: >98%Clinical Data:Size: 10 mg, 50 mg

Purity: 99.12%Clinical Data:Size: 10mM x 1mL in DMSO,

100 mg, 500 mg

Purity: 98.08%Clinical Data: Phase 4Size: 10mM x 1mL in DMSO,

10 mg, 50 mg

 

Bioactivity: Formoterol fumarate(Foradil) is a potent, selective and long-actingβ2-adrenoceptor agonist.

Bioactivity: Guanabenz Acetate is an alpha-2 selective adrenergic agonist usedas an antihypertensive agent.

Bioactivity: Guanfacine is a selective α2A receptor agonist. Bioactivity: Guanfacine Hcl, an anti-hypertensive agent, is a selectiveα2A-adrenoceptor agonist with Kd of 31 nM and displays 60-foldselectivity over α2B-adrenoceptors.

Bioactivity: HOKU-81, a new bronchodilator, is one of the metabolites oftulobuterol.

Bioactivity: Hydrocortisone 17-butyrate is an adrenocortico hormone.

Bioactivity: ICI 118,551 (hydrochloride) is a highly selective β2 adrenergic antagonist, with values of 0.7, 49.5 and 611 nM for β2, β1receptor Ki

and β3 receptors, respectively.

Bioactivity: Indacaterol(Onbrez; Arcapta) is an ultra-long-acting β-adrenoceptoragonist.

Bioactivity: Indacaterol Maleate is an ultra-long-acting β-adrenoceptor agonist. Bioactivity: Indoramin D5 is deuterium labeled Indoramin, which is a piperidineantiadrenergic agent.

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Formoterol (Fumarate)(Formoterol) Cat. No.: HY-B0010

Guanabenz (Acetate)(Wy8678 acetate) Cat. No.: HY-B0566

GuanfacineCat. No.: HY-17416A

Guanfacine (hydrochloride)(Guanfacine) Cat. No.: HY-17416

HOKU-81(4-Hydroxytulobuterol; HOKU 81; HOKU81) Cat. No.: HY-50291

Hydrocortisone 17-butyrate(Cortisol 17-butyrate; Hydrocortisone butyrate) Cat. No.: HY-B0983

ICI 118,551 (hydrochloride) (ICI 118551 hydrochloride;

ICI-118551 hydrochloride; ICI118551 hydrochloride) Cat. No.: HY-13951

IndacaterolCat. No.: HY-14299

Indacaterol (maleate)Cat. No.: HY-14299A

Indoramin D5(Indoramine D5; Wy-21901 D5) Cat. No.: HY-12760S

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Purity: >98.0%Clinical Data:Size: 10mM x 1mL in DMSO,

100 mg

Purity: 99.12%Clinical Data:Size: 10mM x 1mL in DMSO,

1 g, 5 g

Purity: 99.87%Clinical Data:Size: 10mM x 1mL in DMSO,

1 g, 5 g

Purity: >98%Clinical Data:Size: 1 g

Purity: >98.0%Clinical Data:Size: 10mM x 1mL in DMSO,

1 g

Purity: >98%Clinical Data:Size: 1 g

Purity: 98.39%Clinical Data:Size: 10mM x 1mL in DMSO,

10 mg, 50 mg

Purity: >98%Clinical Data:Size: 1 mg, 5 mg

Purity: >98%Clinical Data:Size: 1 mg, 5 mg, 10 mg

Purity: >98.0%Clinical Data:Size: 10mM x 1mL in DMSO,

200 mg, 1 g

 

Bioactivity: Isoprenaline (hydrochloride) is a non-selective beta-adrenergic agonist, used for the treatment of bradycardia and heartreceptor

block.

Bioactivity: Ivabradine D3 hydrochloride is the deuterium labeled Ivabradine,which is an If(Funny current) inhibitor with IC 50 of 2

Bioactivity: Ivabradine D6 hydrochloride is the deuterium labeled Ivabradine,which is an If(Funny current) inhibitor with IC 50 of 2

Bioactivity: Ivabradine (hydrochloride) is a new I inhibitor with IC of 2.9 μM,f 50and used as a pure heart rate lowering agent.

Bioactivity: Methyldopa is an alpha-adrenergic agonist (selective forα2-adrenergic receptors) psychoactive drug used as a sympatholyticor antihypertensive.

Bioactivity: L-(-)-α-Methyldopa hydrate is an alpha-adrenergic agonist (selectivefor α2-adrenergic receptors) psychoactive drug used as asympatholytic or antihypertensive.

Bioactivity: L-(-)-α-Methyldopa hydrochloride is an alpha-adrenergic agonist(selective for α2-adrenergic receptors) psychoactive drug used as asympatholytic or antihypertensive.

Bioactivity: L-Epinephrine(L-Adrenaline) is a hormone and a neurotransmitter.

Bioactivity: L-Epinephrine Bitartrate is alpha- and beta-adrenergic receptorstimulator.

Bioactivity: Labetalol hydrochloride is a mixed alpha/beta adrenergic antagonistthat is used to treat high blood pressure.

Isoprenaline (hydrochloride)(Isoproterenol hydrochloride) Cat. No.: HY-B0468

Ivabradine (D3 Hydrochloride)Cat. No.: HY-B0162AS1

Ivabradine (D6 hydrochloride)Cat. No.: HY-B0162AS

Ivabradine (hydrochloride)Cat. No.: HY-B0162A

L-(-)-α-Methyldopa(MK-351; Methyldopa) Cat. No.: HY-B0225

L-(-)-α-Methyldopa (hydrate)(MK-351 hydrate; Methyldopa hydrate) Cat. No.: HY-B0225B

L-(-)-α-Methyldopa (hydrochloride)(MK-351 hydrochloride; Methyldopa hydrochloride) Cat. No.: HY-B0225A

L-Epinephrine((-)-Epinephrine; L-Adrenaline; (-)-Adrenalin) Cat. No.: HY-B0447B

L-Epinephrine (Bitartrate) ((-)-Epinephrine (+)-bitart

rate salt; L-Adrenaline (+)-bitartrate salt) Cat. No.: HY-B0447A

Labetalol (hydrochloride)(AH-5158 hydrochloride; Sch-15719W) Cat. No.: HY-B1108

Purity: >98%Clinical Data:Size: 100 mg

Purity: 99.25%Clinical Data: Phase 1, Phase 3Size: 10mM x 1mL in DMSO,

100 mg

Purity: >98%Clinical Data: Phase 1, Phase 3Size: 100 mg

Purity: >98.0%Clinical Data:Size: 10mM x 1mL in DMSO,

1 g

Purity: 98%Clinical Data:Size: 10mM x 1mL in DMSO,

100 mg

Purity: 99.85%Clinical Data:Size: 10mM x 1mL in DMSO,

50 mg, 100 mg

Purity: 99.88%Clinical Data:Size: 10mM x 1mL in DMSO,

5 mg, 10 mg, 50 mg

Purity: >98%Clinical Data:Size: 500 mg

Purity: 98.93%Clinical Data:Size: 10mM x 1mL in DMSO,

10 mg, 50 mg, 100 mg

Purity: >98%Clinical Data: Phase 3Size: 10 mg, 50 mg

 

Bioactivity: Levosalbutamol tartrate(levalbuterol) is the R-enantiomer of theshort-acting β2-adrenergic receptor agonist salbutamol.

Bioactivity: Levobetaxolol hydrochloride is a beta-adrenergic receptor inhibitor(beta blocker), used to lower the pressure in the eye in treatingconditions such as glaucoma.

Bioactivity: Lofexidine hydrochloride is an α2A-adrenergic receptor agonist,commonly used to alleviate the physical symptoms of heroin andother types of opioid withdrawal.

Bioactivity: Medetomidine(Domtor) is a potent, highly selective α2-adrenoceptoragonist (Ki values are 1.08 and 1750 nM for α2- andα1-adrenoceptors respectively).

Bioactivity: Medetomidine Hydrochloride is an agonist of adrenergic alpha-2receptor, which is used in veterinary medicine for its analgesic andsedative properties.

Bioactivity: Metaraminol tartrate is an α1-adrenergic receptor agonistis a potentsympathomimetic amine used in the prevention and treatment ofhypotension, particularly as a complication of anesthesia.

Bioactivity: Methoxyphenamine Hydrochloride is a β-adrenergic receptor agonistof the amphetamine class used as a bronchodilator.

Bioactivity: Metoprolol (Toprol) is a selective β1 receptor blocker used intreatment of several diseases of the cardiovascular system, especiallyhypertension

Bioactivity: Metoprolol Succinate (Toprol XL) is a selective β1 receptor blockerused in treatment of several diseases of the cardiovascular system,especially hypertension.

Bioactivity: Metoprolol is a cardioselective β1-adrenergic blocking agent.

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Levalbuterol (tartrate)(Levosalbutamol tartrate) Cat. No.: HY-17457

Levobetaxolol (hydrochloride)((S)-Betaxolol hydrochloride; AL-1577A) Cat. No.: HY-B0381B

Lofexidine (hydrochloride)(Baq-168; MDL-14042) Cat. No.: HY-B1052

MedetomidineCat. No.: HY-17034

Medetomidine (hydrochloride)(MPV785) Cat. No.: HY-17034B

Metaraminol (tartrate)(Metaradrine tartrate) Cat. No.: HY-B1116

Methoxyphenamine (Hydrochloride)(NSC-65644) Cat. No.: HY-B1694A

MetoprololCat. No.: HY-17503

Metoprolol (Succinate)Cat. No.: HY-17503A

Metoprolol (Tartrate)Cat. No.: HY-17503B

www.MedChemExpress.com 9

Purity: >98.0%Clinical Data:Size: 10mM x 1mL in DMSO,

500 mg, 1 g, 5 g

Purity: 99.06%Clinical Data:Size: 10mM x 1mL in DMSO,

10 mg, 50 mg

Purity: 99.69%Clinical Data:Size: 10mM x 1mL in DMSO,

10 mg, 50 mg

Purity: >98.0%Clinical Data:Size: 10mM x 1mL in DMSO,

10 mg, 50 mg

Purity: >98%Clinical Data:Size: 5 mg, 10 mg, 50 mg

Purity: 96.55%Clinical Data:Size: 10mM x 1mL in DMSO,

1 g, 5 g, 10 g

Purity: 99.19%Clinical Data:Size: 10mM x 1mL in DMSO,

5 g, 10 g

Purity: >98%Clinical Data:Size: 1 mg, 5 mg

Purity: 99.66%Clinical Data:Size: 10mM x 1mL in DMSO,

100 mg, 1 g

Purity: 99.86%Clinical Data: Phase 3, Phase 4Size: 10mM x 1mL in DMSO,

5 mg, 10 mg, 50 mg

 

Bioactivity: Mirabegron is a selective agonist with of 22.4β -adrenoceptor3 EC50nM.

Bioactivity: Moxisylyte (hydrochloride) is (alpha 1-blocker) antagonistit canvasodilates cerebral vessels without reducing blood pressure.

Bioactivity: Nadolol D9 is the deuterium labeled Nadolol(SQ-11725), which is anon-selective beta blocker.

Bioactivity: Naftopidil (Flivas), a selective α1-adrenergic receptor antagonist oralpha blocker, is an antihypertensive drug.

Bioactivity: Naphazoline HCl is an ocular vasoconstrictor and imidazolinederivative sympathomimetic amine.

Bioactivity: Nebivolol selectively inhibits β1- adrenergic receptor with IC50 of 0.8nM.

Bioactivity: Nebivolol hydrochloride selectively inhibits β1- adrenergic receptorwith IC50 of 0.8 nM.

Bioactivity: Nefazodone hydrochloride is an antidepressant drug.

Bioactivity: Nicergoline is an ergot derivative used to treat senile dementia andother disorders with vascular origins.

Bioactivity: Norepinephrine bitartrate monohydrate is a -selective β1 adrenergic

agonist with of 5.37 μM.receptor EC50

Mirabegron(YM-178; YM 178; YM178) Cat. No.: HY-14773

Moxisylyte (hydrochloride)(Thymoxamine hydrochloride) Cat. No.: HY-B1435

Nadolol D9(SQ-11725 D9) Cat. No.: HY-B0804S

Naftopidil (KT-611; BM-15275; KT611;

BM15275; KT 611; BM 15275) Cat. No.: HY-B0391

Naphazoline (hydrochloride)Cat. No.: HY-B0446

Nebivolol(R 065824) Cat. No.: HY-B0203

Nebivolol (hydrochloride)(R 065824 hydrochloride) Cat. No.: HY-B0203A

Nefazodone (hydrochloride)(BMY-13754; MJ-13754-1) Cat. No.: HY-B1396

NicergolineCat. No.: HY-B0702

Norepinephrine (bitartrate monohydrate)(Noradrenaline bitartrate monohydrate) Cat. No.: HY-13715B

Purity: >98.0%Clinical Data:Size: 10mM x 1mL in DMSO,

200 mg, 500 mg

Purity: >98%Clinical Data:Size: 1 mg, 5 mg, 10 mg

Purity: 99.93%Clinical Data:Size: 10mM x 1mL in DMSO,

1 g, 5 g

Purity: >98%Clinical Data:Size: 10 mg, 50 mg

Purity: 98.89%Clinical Data:Size: 10mM x 1mL in DMSO,

5 mg, 10 mg, 50 mg, 100 mg

Purity: >98%Clinical Data: Phase 3Size:

Purity: 99.97%Clinical Data:Size: 10mM x 1mL in DMSO,

100 mg, 500 mg

Purity: >98%Clinical Data: Phase 3Size: 10mM x 1mL in Water,

2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Purity: 99.56%Clinical Data:Size: 10mM x 1mL in DMSO,

1 g, 5 g

Purity: >98%Clinical Data:Size: 500 mg, 1 g, 5 g

 

Bioactivity: Norepinephrine hydrochloride is a -selective β1 adrenergic receptor

agonist with of 5.37 μM.EC50

Bioactivity: Octopamine Hydrochloride is an endogenous biogenic amine that isclosely related to norepinephrine, and has effects on the adrenergicand dopaminergic systems.

Bioactivity: Olodaterol (BI1744) is a long acting agonist withβ -adrenoceptor2an of 1.4±0.08 nM.EC50

Bioactivity: Oxymetazoline Hydrochloride is a selective alpha-1 agonist andpartial alpha-2 agonist topical decongestant.

Bioactivity: Pardoprunox(SLV-308) is a novel partial dopamine D2 and D3receptor agonist and serotonin 5-HT1A receptor agonist; D2 (pKi =8.1) and D3 receptor (pKi = 8.6) partial agonist (IA = 50% and 67%,respectively) and 5-HT1A receptor (pKi = 8.5) full agonist (IA =100%); also binds to D4 (pKi = 7.8), α1-adrenergic (pKi = 7.8),α2-adre…

Bioactivity: Pardoprunox hydrochloride is a novel partial dopamine D2 and D3receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi =8.1) and D3 receptor (pKi = 8.6) partial agonist and 5-HT1A receptor(pKi = 8.5) full agonist.

Bioactivity: Penbutolol sulfate is able to bind to both beta-1 adrenergicreceptors and beta-2 adrenergic receptors (the two subtypes), thusmaking it a non-selective β blocker. Penbutolol is a sympathomimeticdrugused in the treatment of high blood pressure.

Bioactivity: Perphenazine is a typical antipsychotic drug, inhibits 5-HT2A receptor(5-HT2A), Alpha-1A adrenergic receptor (α1A), Dopamine receptorD2/D3, D2L receptor, and Histamine H1 receptor (H1) with Ki of 5.6,10, 0.765/0.13, 3.4, and 8 nM.

Bioactivity: Perphenazine D8 Dihydrochloride is the deuterium labeledPerphenazine, which is a typical antipsychotic drug(5-HT, Dopaminereceptor ligand).

Bioactivity: Phenoxybenzamine HCl is a non-specific, irreversible alphaantagonist with long duration of action.

10 Tel: 609-228-6898 Fax: 609-228-5909 Email: sales@medchemexpress.com

Norepinephrine (hydrochloride)(Noradrenaline hydrochloride) Cat. No.: HY-13715A

Octopamine (hydrochloride)((±)-p-Octopamine hydrochloride) Cat. No.: HY-B0528A

Olodaterol(BI1744) Cat. No.: HY-14301

Oxymetazoline (hydrochloride)Cat. No.: HY-B0427A

Pardoprunox(SLV-308; DU-126891) Cat. No.: HY-14958

Pardoprunox (hydrochloride)(SLV-308 hydrochloride; DU-126891 hydrochloride) Cat. No.: HY-14958A

Penbutolol (sulfate)((-)-Terbuclomine) Cat. No.: HY-B1154

PerphenazineCat. No.: HY-A0077

Perphenazine (D8 Dihydrochloride)Cat. No.: HY-A0077AS

Phenoxybenzamine (hydrochloride)Cat. No.: HY-B0431A

www.MedChemExpress.com 11

Purity: >98%Clinical Data:Size: 10 mg, 50 mg, 100 mg

Purity: 99.74%Clinical Data:Size: 10mM x 1mL in DMSO,

100 mg, 500 mg

Purity: 99.57%Clinical Data:Size: 10mM x 1mL in DMSO,

100 mg, 500 mg

Purity: >98%Clinical Data:Size: 100 mg

Purity: 99.91%Clinical Data:Size: 10mM x 1mL in DMSO,

100 mg, 200 mg, 500 mg

Purity: >98%Clinical Data:Size: 10 mg

Purity: >98%Clinical Data:Size: 1 mg, 5 mg, 10 mg

Purity: 99.68%Clinical Data:Size: 10mM x 1mL in DMSO,

2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Purity: >98%Clinical Data:Size: 100 mg, 500 mg

Purity: 99.42%Clinical Data:Size: 10mM x 1mL in DMSO,

100 mg, 500 mg

 

Bioactivity: Phentolamine Mesylate is a nonselective alpha-adrenergicantagonist.

Bioactivity: Pindolol is a nonselective β-blocker with partial beta-adrenergicreceptor agonist activity, also functions as a 5-HT1A receptor weakpartial agonist / antagonist (Ki=33nM).

Bioactivity: Piperoxan hydrochloride is an α adrenoceptor antagonist.2 Bioactivity: Piribedil D8 is the deuterium labeled Piribedil, which is anantiparkinsonian agent.

Bioactivity: Prazosin is an alpha-adrenergic blocker and is a sympatholytic drugused to treat high blood pressure and anxiety, PTSD, and panicdisorder.

Bioactivity: Prazosin is an alpha-adrenergic blocker and is a sympatholytic drugused to treat high blood pressure and anxiety, PTSD, and panicdisorder

Bioactivity: Pronethalol is a non-selective beta-adrenergic blocking agent,protect against and to reverse Digitalis-induced ventriculararrhythmias.

Bioactivity: Propranolol Hydrochloride is a widely used non-cardioselectivebeta-adrenergic antagonist

Bioactivity: Ritodrine HCl is a β-2 adrenergic receptor agonist. Bioactivity: Salbutamol is a short-acting β2-adrenergic receptor agonist used forthe relief of bronchospasm in conditions such as asthma and chronicobstructive pulmonary disease (COPD).

Phentolamine (mesylate)(Phentolamine methanesulfonate) Cat. No.: HY-B0362A

PindololCat. No.: HY-B0982

Piperoxan (hydrochloride)(dl-Piperoxan hydrochloride) Cat. No.: HY-100850

Piribedil D8(ET-495 D8) Cat. No.: HY-12707S

PrazosinCat. No.: HY-B0193

Prazosin (hydrochloride)Cat. No.: HY-B0193A

Pronethalol((±)-Pronethalol) Cat. No.: HY-B1238

Propranolol (hydrochloride)Cat. No.: HY-B0573

Ritodrine (hydrochloride)(DU21220) Cat. No.: HY-B0452

Salbutamol(Albuterol; AH-3365) Cat. No.: HY-B1037

Purity: >98%Clinical Data:Size: 10 mg, 50 mg, 100 mg

Purity: 99.61%Clinical Data:Size: 10mM x 1mL in DMSO,

100 mg

Purity: 99.08%Clinical Data:Size: 10mM x 1mL in DMSO,

100 mg, 500 mg

Purity: 98.51%Clinical Data:Size: 10mM x 1mL in DMSO,

50 mg, 100 mg

Purity: 99.29%Clinical Data: Phase 4Size: 10mM x 1mL in DMSO,

10 mg, 50 mg, 100 mg

Purity: >98.0%Clinical Data:Size: 10mM x 1mL in DMSO,

10 mg, 50 mg, 100 mg

Purity: >98%Clinical Data:Size: 10 mg, 50 mg, 100 mg

Purity: 97.66%Clinical Data: Phase 4Size: 10mM x 1mL in DMSO,

10 mg, 50 mg, 100 mg, 200 mg

Purity: >98%Clinical Data:Size: 10 mg, 50 mg

Purity: >98.0%Clinical Data:Size: 10mM x 1mL in Water,

100 mg, 500 mg

 

Bioactivity: Salbutamol Hemisulfate is a short-acting β2 adrenergic receptoragonist Target: β2 Adrenergic Receptor Salbutamol is a short-acting,selective beta2-adrenergic receptor agonist used in the treatment ofasthma and COPD

Bioactivity: Salmeterol is a long-acting beta2-adrenergic receptor (beta 2AR)agonist used clinically to treat asthma.

Bioactivity: Salmeterol(GR 33343X) xinafoate is a long-acting beta2-adrenergicreceptor agonist drug that is prescribed for the treatment of asthmaand chronic obstructive pulmonary disease(COPD).

Bioactivity: Scopine is the metabolite of anisodine, which is a α1-adrenergicreceptor agonist and used in the treatment of acute circulatoryshock.

Bioactivity: Scopine Hcl salt is the metabolite of anisodine, which is aα1-adrenergic receptor agonist and used in the treatment of acutecirculatory shock.

Bioactivity: Silodosin (Rapaflo; KMD-3213) is an α1-adrenoceptor antagonistwith high uroselectivity; In treatment of dysuria.

Bioactivity: Sotalol Hydrochloride is an adrenergic beta-antagonist that is used inthe treatment of life-threatening arrhythmias.

Bioactivity: Synephrine Hcl(Oxedrine) is an alkaloid; synephrine produces most ofits biological effects by acting as an agonist at adrenergic receptors.

Bioactivity: Tamsulosin is a selective α1 receptor antagonist. Bioactivity: Tamsulosin hydrochloride((R)-(-)-YM12617;LY253351) is a selectiveα1 receptor antagonist.

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Salbutamol (hemisulfate)Cat. No.: HY-B0436

Salmeterol(GR33343X) Cat. No.: HY-14302

Salmeterol (xinafoate)(GR 33343X xinafoate) Cat. No.: HY-17453

Scopine(6,7-Epoxytropine) Cat. No.: HY-B0459

Scopine (hydrochloride)(6,7-Epoxytropine hydrochloride) Cat. No.: HY-B0459A

Silodosin(KAD 3213; KMD 3213) Cat. No.: HY-10122

Sotalol (hydrochloride)Cat. No.: HY-B0437

Synephrine (hydrochloride)(Oxedrine hydrochloride) Cat. No.: HY-N0132A

TamsulosinCat. No.: HY-B0661

Tamsulosin (hydrochloride)((R)-(-)-YM12617; LY253351) Cat. No.: HY-B0661A

www.MedChemExpress.com 13

Purity: >98%Clinical Data:Size: 10mM x 1mL in DMSO,

100 mg

Purity: 99.86%Clinical Data:Size: 10mM x 1mL in DMSO,

1 g, 5 g

Purity: >98%Clinical Data: No Development ReportedSize: 1 g, 5 g

Purity: 99.88%Clinical Data:Size: 10mM x 1mL in DMSO,

10 mg, 50 mg, 100 mg

Purity: >98%Clinical Data:Size: 10 mg, 50 mg, 100 mg

Purity: 99.72%Clinical Data:Size: 10mM x 1mL in DMSO,

1 g, 5 g

Purity: >98.0%Clinical Data:Size: 10mM x 1mL in Water,

1 g, 5 g

Purity: 98.87%Clinical Data:Size: 10mM x 1mL in DMSO,

100 mg

Purity: >98%Clinical Data:Size: 100 mg, 500 mg

Purity: >98%Clinical Data: Phase 4Size:

 

Bioactivity: Tapentadol (hydrochloride) is a centrally acting oral analgesic withopioid and adrenergic activity.

Bioactivity: Terazosin is a selective alpha1-antagonist used for treatment ofsymptoms of benign prostatic hyperplasia (BPH).

Bioactivity: Terazosin Hydrochloride dihydrate is a selective alpha1-antagonistused for treatment of symptoms of benign prostatic hyperplasia(BPH).

Bioactivity: Terbutaline sulfate is a β2-adrenergic receptor agonist; a fast-actingbronchodilator and a tocolytic to delay premature labor.

Bioactivity: Tetrahydrozoline (hydrochloride) is a α-adrenoceptor agonist. Bioactivity: Tizanidine is an α2-adrenergic receptor agonist and inhibitsneurotransmitter release from CNS noradrenergic neurons.

Bioactivity: Tizanidine hydrochloride is an α2-adrenergic receptor agonist andinhibits neurotransmitter release from CNS noradrenergic neurons.

Bioactivity: Tolazoline(NSC35110; Imidaline) is a non-selective competitiveα-adrenergic receptor antagonist.

Bioactivity: Tolazoline(NSC35110; Imidaline) Hcl is a non-selective competitiveα-adrenergic receptor antagonist.

Bioactivity: Trimipramine maleate is a serotonin transport and norepinephrineuptake blocker, is a tricyclic antidepressant (TCA) with antipsychoticand sedative properties.

Tapentadol (hydrochloride)Cat. No.: HY-70042A

TerazosinCat. No.: HY-B0371

Terazosin (hydrochloride dihydrate)Cat. No.: HY-B0371A

Terbutaline (sulfate)(Terbutaline hemisulfate) Cat. No.: HY-B0802

Tetrahydrozoline (hydrochloride)(Tetryzoline hydrochloride) Cat. No.: HY-B0556A

TizanidineCat. No.: HY-B0194

Tizanidine (hydrochloride)Cat. No.: HY-B0194A

Tolazoline(NSC35110) Cat. No.: HY-A0066

Tolazoline (hydrochloride)(Imidaline hydrochloride; Benzidazol hydrochloride) Cat. No.: HY-A0066A

Trimipramine (maleate)(Trimipramine maleate salt) Cat. No.: HY-B1213

Purity: >98%Clinical Data: Phase 3Size: 1 g

Purity: 99.85%Clinical Data:Size: 10mM x 1mL in DMSO,

1 g

Purity: 99.9%Clinical Data:Size: 10mM x 1mL in DMSO,

100 mg, 500 mg

Purity: >98%Clinical Data:Size: 100 mg, 500 mg

Purity: 98.56%Clinical Data: Phase 3, Phase 4Size: 10mM x 1mL in DMSO,

5 mg, 10 mg, 50 mg, 100 mg

Purity: >98%Clinical Data: Phase 3Size: 10mM x 1mL in DMSO,

5 mg, 10 mg, 50 mg, 100 mg

Purity: >98%Clinical Data:Size:

Purity: >98%Clinical Data:Size: 100 mg, 500 mg

Purity: 99.81%Clinical Data:Size: 10mM x 1mL in DMSO,

10 mg, 50 mg, 100 mg

Purity: >98%Clinical Data:Size: 5 mg, 10 mg, 50 mg, 100 mg

 

Bioactivity: UK 14,304 is a full α2-adrenergic receptor (α2-AR) agonist. Bioactivity: UK 14,304 is a full α2-adrenergic receptor (α2-AR) agonist.

Bioactivity: Urapidil HCl is an α1-adrenoceptor antagonist and 5-HT1A receptoragonist.

Bioactivity: Vanilpyruvic acid is a catecholamine metabolite and precursor tovanillactic acid.

Bioactivity: Vilanterol (GW642444; GW 642444X) is a novel, inhaled, long-actingβ(2) agonist with inherent 24-h activity under development as aonce-daily combination therapy with an inhaled corticosteroid forCOPD and asthma.

Bioactivity: Vilanterol trifenatate is a long-acting (β -AR)β -adrenoceptor2 2agonist with 24 h activity. The s for β -AR,β -AR and β -AR ispEC50 2 1 310.37±0.05, 6.98±0.03 and 7.36±0.03, respectively.

Bioactivity: Xylazine is α2 class of adrenergic receptor agonist. Bioactivity: Xylazine Hydrochloride is α2 class of adrenergic receptor agonist.

Bioactivity: Xylometazoline Hydrochloride is an α-adrenoceptor agonistcommonly used as nasal decongestant.

Bioactivity: Yohimbine is a potent and relatively nonselective alpha 2-adrenergicreceptor (AR) antagonist, with IC50 of 0.6 μM.

14 Tel: 609-228-6898 Fax: 609-228-5909 Email: sales@medchemexpress.com

UK 14,304(Brimonidine; AGN190342; UK14304) Cat. No.: HY-B0659

UK 14,304 (tartrate) (Brimonidine tartrate; AGN190342 tartra

te; UK14304 tartrate) Cat. No.: HY-B0659A

Urapidil (hydrochloride)Cat. No.: HY-B0354A

Vanilpyruvic acid(Vanylpyruvic acid) Cat. No.: HY-101416

Vilanterol (GW 642444X; GW 642444; GW642444X; GW642444; GW-642444

X; GW-642444) Cat. No.: HY-14300

Vilanterol (trifenatate)(GW642444M; GW 642444M; GW-642444M) Cat. No.: HY-14300A

Xylazine(BAY1470; BAY-1470; BAY 1470) Cat. No.: HY-B0443

Xylazine (hydrochloride) (BAY1470 hydrochloride; BAY-1470 hydroc

hloride; BAY 1470 hydrochloride) Cat. No.: HY-B0443A

Xylometazoline (hydrochloride)Cat. No.: HY-B0475

YohimbineCat. No.: HY-12715

www.MedChemExpress.com 15

Purity: 99.79%Clinical Data:Size: 10mM x 1mL in DMSO,

1 g

 

Bioactivity: Yohimbine hydrochloride is an alpha 2-adrenoreceptor antagonist,blocking the pre- and postsynaptic alpha-2 adrenoreceptors andcausing an increased release of noradrenaline and dopamine.

Yohimbine (Hydrochloride)Cat. No.: HY-N0127