Adrenergic alpha2BAdrenergic alpha2CAdrenergic alpha2: Non-SelectiveAdrenergic beta1Adrenergic beta2Adrenergic beta3Transporter: NorepinephrineAngiotensin AT1Angiotensin AT2Atrial Natriuretic FactorBombesin: Non-SelectiveBradykinin B2CalcitoninCalcitonin Gene-Related Peptide CGRP1Calcium Channel L-Type: BenzothiazepineCalcium Channel L-Type: DihydropyridineCalcium Channel L-Type: PhenylalkylamineCalcium Channel N-TypeCannabinoid CB1Cannabinoid CB2Chemokine CCR1Chemokine CCR5Cholecystokinin CCK1 (CCKA)Cholecystokinin CCK2 (CCKB)Transporter: CholineDopamine D1Dopamine D2SDopamine D3Dopamine D4.4Dopamine D5Transporter: DopamineEndothelin ETAEndothelin ETBEpidermal Growth FactorEstrogen ERalphaEstrogen ERbetaTransporter: GABAGABAA: Agonist SiteGABAA: Chloride ChannelGABAB: Non-SelectiveGalanin GAL1Galanin GAL2

GlucocorticoidGlutamate: AMPAGlutamate: KainateGlutamate: NMDA: AgonismGlutamate: NMDA: GlycineGlutamate: NMDA: PhencyclidineGlutamate: Non-SelectiveGlycine: Strychnine-SensitiveHistamine H1Histamine H2Histamine H3Inositol Trisphosphate IP3InsulinChemokine CXCR2 (IL-8B)Leukotriene LTD4Melanocortin MC3Melanocortin MC4Melanocortin MC5Melatonin ML: Non-SelectiveTransporter: MonoamineMuscarinic M1Muscarinic M2Muscarinic M3Muscarinic M4Muscarinic M5Tachykinin NK1Tachykinin NK2Tachykinin NK3Neuropeptide Y1Neuropeptide Y2Nicotinic AcetylcholineOpiate delta (OP1: DOP)Opiate kappa (OP2: KOP)Opiate mu (OP3: MOP)Orphanin ORL1Platelet Activating FactorPotassium Channel [KA]Potassium Channel [KATP]Potassium Channel [SKCA]Purinergic P2XSerotonin 5-HT1: Non-SelectiveSerotonin 5-HT1A

Serotonin 5-HT1BSerotonin 5-HT2: Non-SelectiveSerotonin 5-HT2ASerotonin 5-HT2BSerotonin 5-HT2CSerotonin 5-HT3Serotonin 5-HT4Serotonin 5-HT6Serotonin 5-HT7Transporter: SerotoninSodium Channel: Site 2Somatostatin sst5TestosteroneProstanoid: Thromboxane A2Thyrotropin Releasing HormoneVasoactive Intestinal Peptide VIP1Vasopressin V1AProstanoid EP1Prostanoid EP3Prostanoid EP4Prostanoid FPProstanoid DPProstanoid IPSomatostatin sst1Somatostatin sst2Somatostatin sst3Somatostatin sst4GABA-alpha1beta3gamma2GABA-alpha1beta3gamma2GABA-alpha5beta3gamma2GABA-alpha5beta3gamma2NMDA-NR1a/NR2a - AntagonistOxytocinPPAR alpha - AntagonistPPARgamma - AntagonistBradykinin B1 - AntagonistNeurotensin NT1 - AntagonistPotassium Channel: HERG - AntagonistVasopressin V1b - AntagonistVasopressin V2 - Antagonist

AcetylcholinesterasePeptidase: Cathepsin GPeptidase Matrix Metalloproteinase-1Cyclooxygenase COX-1Cyclooxygenase COX-2Lipoxygenase 5-LOMonoamine Oxidase MAO-AMonoamine Oxidase MAO-BNitric Oxide Synthase: NeuronalNitric Oxide Synthase: InduciblePhosphodiesterase PDE1Phosphodiesterase PDE2Phosphodiesterase PDE3Phosphodiesterase PDE4Phosphodiesterase PDE5Phosphodiesterase PDE6Peptidase: Caspase 1Peptidase: Caspase 3Peptidase: Caspase 6Peptidase: Caspase 7Peptidase: Caspase 8Peptidase: Metalloproteinase: Neutral EndopeptidasePeptidase: Leukocyte ElastaseProtein Tyrosine Kinase: EGF ReceptorProtein Serine/Threonine Kinase: ERK1Protein Tyrosine Kinase: Insulin ReceptorProtein Serine/Threonine Kinase: p38alphaProtein Tyrosine Kinase: pp60srcProtein Serine/Threonine Kinase: PKA: Non-SelectiveProtein Serine/Threonine Kinase: PKC: Non-SelectiveProtein Serine/Threonine Kinase: PKCalphaProtein Tyrosine Phosphatase: CD45Protein Tyrosine Phosphatase: PTP1BProtein Tyrosine Phosphatase: T-CellTyrosine HydroxylaseAdenosine A1Adenosine A2AAdenosine A3Transporter: AdenosineAdrenergic alpha1DAdrenergic alpha1: Non-SelectiveAdrenergic alpha2A

Supplemental TABLEList of the 166 target molecules screened at MDS Pharma