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AdaptiveBehaviorandPsychiatricSymptomsusingthe BehaviorAssessmentSystemforChildren– Version3:ResultsfromtheABC-CTFeasibilityStudy
• Evaluationsofschool-agedchildrenwithautismspectrumdisorder(ASD)includebothcoresymptoms(e.g.socialcommunication)andco-occurringbehaviors(e.g.adaptivebehavior(1)andpsychiatricsymptoms(3)).
• Assessingmultipledomainsofbehavioroftenrequiresindividualizedstandardizedassessmentswhichcanbeburdensomeonfamilies(4).
• TheBehaviorAssessmentSystemforChildren- Version3 (BASC-3)isacomprehensiveratingscalethatassaysmultipledomainsofbehavior(2).
• WeaskedwhethertheBASC-3candifferentiateASDfromtypically-developing(TD)school-agedchildrenandwhetheritdemonstratesconvergencewithmorecommonly-usedmeasuresofadaptivefunctioningandpsychiatricsymptoms.
1) InvestigategroupdifferencesinadaptivebehaviorandpsychiatricsymptomsinchildrenwithASDandTDusingtheBASC-3 compositescores.Hypothesis:ChildrenwithASDwillshowdecreasedadaptivebehaviorandIncreasedpsychiatricsymptomscomparedtoTD.
2) ExamineconvergentvalidityoftheBASC-3 inchildrenwithASDbycomparingthismeasuretotheVinelandAdaptiveBehaviorScales,SecondEdition(VABS-II)parentinterviewandtheChildandAdolescentSymptomInventory-5(CASI-5)/EarlyChildhoodInventory-5(ECI-5).Hypothesis:TheBASC-3 domainswillcorrelatetocorrespondingVABS-II,CASI-5/ECI-5 domains.
Participants:• EnrolledintheAutismBiomarkersConsortiumforClinicalTrialsStudy(ABC-CT),amulti-site
feasibilitystudyincludingbehavioralandexperimentalmeasures• Eligibility:
- ASDmetcriteriaontheAutismDiagnosticObservationSchedule-IIModule1,2,or3(ADOS-II),AutismDiagnosticInterview-Revised(ADI-R)- TDscreenednegativeforpsychiatricdisorders- ParticipantsincludedinthissamplecompletedtheBASC-3,CASI-5/ECI-5 andVABS-IImeasures
QuestionnairesandInterviews:• BASC-3:parentratingscaletoevaluateadaptiveandchallengingsocialandemotionalbehaviors
acrosscommunityandhomesettings(2)- Comprehensivescoringincludes:compositescales(i.e.internalizingproblems),clinicalscales(i.e.depression)adaptivescales(i.e.socialskills),contentscales(i.e.executivefunctioning)andclinicalindices(i.e.Autismprobability)- 10-20minutes- 175questions
• CASI-5/ECI-5: parentratingscalebasedin DSM-5-toassesssymptomsrelatedtovariouspsychiatricdisorders
- 10-20minutes- 173questions
• VABS-II(SurveyInterviewForm):parentinterviewtoassessadaptivebehaviorsacrossthelifespan- 30-60minutes
StatisticalPlan:• Aim1:Independentsamplet-teststoexaminegroupdifferences• Aim2:Correlationstoexamineconvergentvalidity
SummaryofResults:• ThefollowingBASC-3 domainswithintheASCpositivelycorrelatedwithcorrespondingVABS-II
domains:• FunctionalCommunication(BASC-3)&Communication(VABS-II)• DailyLivingSkills(BASC-3)&ActivitiesofDailyLiving(VABS-II)
• TheSocialSkillsdomainoftheBASC-3 didnotcorrelatewiththeSocializationdomainoftheVABS-II.However,theBASC-3AdaptabilitydomainwaspositivelyrelatedtotheVABS-II CopingSkillssub-domain.
• ThefollowingBASC-3 psychiatricsymptomdomainspositivelycorrelatedwithcorrespondingCASI-5/ECI-5 domains:
• Anxiety(BASC-3)&GeneralizedAnxiety(CASI-5/ECI-5)• Depression(BASC-3)&Dysthymic(CASI-5/ECI-5)• AttentionProblems(BASC-3)&Inattentive(CASI-5/ECI-5)• Hyperactivity(BASC-3)&Hyperactive-Impulsive(CASI-5/ECI-5)
Conclusions:• TheBASC-3 differentiatedchildrenwithASDcomparedtoTDacrossallCompositescores.• TheBASC-3 AdaptiveSkillsCompositedomainsdemonstrateconvergentvaliditywiththeVABS-II,
withtheexceptionofSocialSkills.BASC-3 SocialSkillsmayberepresentingamorenarrowsetofbehaviorsthanVABS-IISocialization,whichisanimportantconsiderationwhenusingthismeasureinASD.
• Insettingswheremultipledomainsneedtobeassessedinatime-efficientmanner,theBASC-3maybeanappropriatealternativetoindividualizedassessments.
Introduction
Objectives
Methods
Conclusions
1. Kanne,S.M.,Gerber,A.J.,Quirmbach,L.M.,Sparrow,S.S.,Cicchetti,D.V.,&Saulnier,C.A.(2010).TheRoleofAdaptiveBehaviorinAutismSpectrumDisorders:ImplicationsforFunctionalOutcome. JournalofAutismandDevelopmentalDisorders,41(8),1007-1018.doi:10.1007/s10803-010-1126-42. Reynolds,C.R.,&Kamphaus,R.W.(2015).BASC3:Behaviorassessmentsystemforchildren:Manual.Bloomington,MN:PsychCorp.3. Rosen,T.E.,Mazefsky,C.A.,Vasa,R.A.,&Lerner,M.D.(2018).Co-occurringpsychiatricconditionsinautismspectrumdisorder. InternationalReviewofPsychiatry.doi:10.1080/09540261.2018.14502294. Sikora,D.M.,Hall,T.A.,Hartley,S.L.,Gerrard-Morris,A.E.,&Cagle,S.(2007).DoesParentReportofBehaviorDifferAcrossADOS-GClassifications:AnalysisofScoresfromtheCBCLandGARS.JournalofAutismandDevelopmentalDisorders,38(3),440-448.doi:10.1007/s10803-007-0407-z
WethanktheNationalInstituteofHealthforfundingthisstudy.GrantNIMH#1U19MH108206-01,PI:McPartland.Wegreatlyappreciateallofthefamilieswhoparticipatedinthisresearchacrossstudysites(YaleUniversity,UniversityofWashington,BostonChildren’sHospital,DukeUniversity).
References
Acknowledgements
ResultsAim1cont.
EmilyPompan1,ElizabethBaker1,PatriciaRenno,Ph.D. 1,SaraWebb,Ph.D.5,FrederickShic,Ph.D.5,AdamNaples,Ph.D.2,CatherineSugar,Ph.D.1,MichaelMurias,Ph.D. 4,RaphaelBernier,Ph.D. 5,GeraldineDawson,Ph.D. 4,CharlesNelson,Ph.D. 3,JamesMcPartland,Ph.D. 2,andShafaliJeste,M.D. 1
UniversityofCalifornia,LosAngeles1,YaleUniversity2,BostonChildren’sHospital3,DukeUniversity4,andtheUniversityofWashington5
ASCDomain GroupDifferences(t-test)
SocialSkills t(47)=6.166,p=<.001
ActivitiesofDailyLiving t(47)=9.425,p=<.001
FunctionalCommunication t(40.99)=11.453,p=<.001
Adaptability t(47)=5.684,p<.001
ResultsAim2bQuestionSample
A.GeneralizedAnxiety/Anxiety
B.Dysthymic/Depression C.Inattentive/AttentionProblems
D.Hyperactive-Impulsive/Hyperactivity
CASI-5/ECI-5
-Cannotgetdistressingthoughtsoutofhis/hermind.
-Talksaboutdeathorsuicide-Haslittleconfidence,feelsinferiortoothers,orisveryself-conscious.
-Iseasilydistractedbyotherthingsgoingon.-Doesnotpayattentiontoclosedetailsormakescarelessmistakes.
-Interruptsorintrudesonotherpeople’sactivities.-Is“onthego”oractsasif“drivenbyamotor.”
BASC-3 -Worriesaboutmakingmistakes.
-Says“Iwanttodie”or“IwishIweredead.”-Seemslonely.
-Iseasilydistracted.-Hastroubleconcentrating.
-Interruptsotherswhentheyarespeaking.-Isinconstantmotion.
BASC-3 AdaptiveSkillsComposite(ASC)DomainScoresinASDComparedtoTD
C. D.
r=.878,p=<.001
r=.431,p=.045 r=.798,p=<.001
EnrolledinABC-CT
IncludedinSample Gender Age(years)
M(SD)
BestIQ- FullScaleorRatioDifferentialAbilitiesScales-II
M(SD)
ADOS-II SeverityScoreM(SD)
ASD n=25 n=22 17male(77%),5female(23%) 8.03(2.28) 93.09(19.41) 14.82(4.54)
TD n=26 n=26 17male(65%),9female(35%) 6.58(1.98) 114.08(9.34) N/A
A. B.
ResultsAim1
BASC-3 Composite GroupDifferences(t-test)
Externalizing t(30.834)=-5.788,p=<.001
Internalizing t(47)=-3.775,p=<.001
BehavioralSymptomsIndex
(BSI)t(47)=-11.965,p=<.001
AdaptiveSkillsComposite(ASC) t(47)=10.558,p=<.001
BASC-3 CompositeScoresinASDandTDGroups
QuestionSample(VABS-II/BASC-3)
A. Communication/FunctionalCommunication
B.DailyLivingSkills/ActivitiesofDailyLiving
C.Socialization/SocialSkills
VABS-II
-Tellsabouteverydayexperiences(i.e.,routine)indetail-Identifiesallalphabetletters
-Understandswhattodoindangeroussituations-Doesatleasttwosimplehouseholdchores
-Avoidsbeingmanipulated,dominatedortakenadvantageofbyothers-Controlsangerorhurtfeelingswhengivenconstructivecriticism.
BASC-3
-Isclearwhentellingaboutpersonalexperiences-Saysalllettersofthealphabetwhenasked
-Actsinasafemanner-Organizeschoresandtaskswell
-Showsinterestinothers’ideas.-Beginsconversationsappropriately
QuestionSample(VABS-II/BASC-3)
D.CopingSkills Sub-Domain/Adaptability
VABS-II
-Handleschangesinroutinewithoutbecomingoverlydistressed-Recoversquicklyfromaminorsetbackordisappointment
BASC-3-Adjustswelltochangesinroutine.-Recoversquicklyfromasetback
TheBASC-3 includesanAdaptabilitydomainwithintheASCthatqualitativelyoverlapswiththeCopingSkillssub-domainwithinVABS-IISocializationdomain.Hypothesis:TheBASC-3 AdaptabilitydomainwillcorrelatewithVABS-II CopingSkillssub-domain.
r=.677,p=<.001r=.580,p=.004A. B.
C.
ResultsAim2a
20 30 40 50 60 70
6
8
10
12
14
16
BASC Adaptability t-score
VAB
S C
opin
g S
kills
v-s
cale
D.
r=.612,p=<.001
40 50 60 70 80 90
40
60
80
100
BASC Depression t-scores
CA
SI/E
CI D
ysth
ymic
t-sc
ores
r=.767,p=<.001
20 30 40 5040
60
80
100
BASC Social Skills t-scores
VAB
S S
ocia
lizat
ion
Sta
ndar
d S
core
s
r=.308,p=.152