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1. Basic Human Pathology Lecture #5 Acute Inflammation / Wound ...
2. Overview: Tissue Responses to Damage
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 1
3. Acute Inflammatory Response
4. Acute Inflammatory Response
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 2
5. Acute Inflammatory Response
6. Acute Inflammatory Response
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 3
7. Formation of Acute Inflammatory Exudate
8. Formation of an Acute Inflammatory Exudate
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 4
9. Clinical Effects of Acute Inflammation
10. “4 + 1” Cardinal Signs of Inflammation
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 5
11. Acute Inflammatory Response
12. Acute Inflammatory Response
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 6
13. Acute Inflammatory Response
14. Acute Inflammatory Response
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 7
15. Acute Inflammatory Response
16. Acute Inflammatory Response
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 8
17. Acute Inflammatory Response
18. Acute Inflammatory Response
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 9
19. Acute Inflammatory Response
20. Key Facts - Neutrophils
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 10
21. Acute Inflammatory Response
22. Acute Inflammatory Response
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 11
23. Acute Inflammatory Response
24. Acute Inflammatory Response
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 12
25. Acute Inflammatory Response
26. Neutrophil Granules and Their Contents
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 13
27. Acute Inflammatory Response
28. Neutrophilic phagocytosis - cont’d
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 14
29. Acute Inflammatory Response
30. Acute Inflammatory Response
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 15
31. Acute Inflammatory Response
32. Acute Inflammatory Response
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 16
33. White Blood Cells (a.k.a. leukocytes or WBC’s)
34. Acute Inflammatory Response
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 17
35. Parulis (gum boil; abscess on the gingiva) = localized accum...
36. Pus draining from a fistula of an abscessed tooth
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 18
37. Fibrinous Exudate – Pericardium
38. Purulent Exudate of the Brain
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 19
39. Abscess in the Skin = Localized Accumulation of Neutrophils...
40. Acute Inflammatory Response
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 20
41. Acute Inflammatory Response
42. Acute Inflammatory Response
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 21
43. Acute Inflammatory Response
44. Acute Inflammatory Response
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 22
45. Acute Inflammatory Response
46. Acute Inflammatory Response
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 23
47. Cell Membrane Phospholipids
48. Endogenous Mediators:
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 24
49. Acute Inflammatory Response
50. Biosynthesis of Leukotrienes and Lipoxins
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 25
51. Acute Inflammation Mechanisms
52. Acute Inflammation Mechanisms
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 26
53. Acute Inflammation Mechanisms
54. Acute Inflammation Mechanisms
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 27
55. Acute Inflammation Mechanisms
56. Acute Inflammation Mechanisms
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 28
57. Acute Inflammation Mechanisms
58. Acute Inflammation Mechanisms
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 29
59. Acute Inflammation Mechanisms
60. Acute Inflammation Mechanisms
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 30
61. Acute Inflammation Mechanisms
62. Acute Inflammation Mechanisms
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 31
63. Acute Inflammation Mechanisms
64. Acute Inflammation Mechanisms
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 32
65. Acute Inflammation Mechanisms
66. Acute Inflammation Mechanisms
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 33
67. Overview of the Complement System
68. Acute Inflammation Mechanisms
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 34
69. Acute Inflammation Mechanisms
70. Acute Inflammatory Response
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 35
71. Acute Inflammatory Response
Tufts OpenCourseWare © 2008 Tufts University
Acute Inflammation/Wound Healing and Repair I
OCW: Basic Human Pathology: Parts I and II (M. Kahn) Page - 36