Activity Report 2006 - UMa · 9000-081 Funchal NIF: 680041982 Research Lines Natural Products Materials Keywords Enology Phitochemistry Materials Biomaterials . Centro de Química

Activity Report 2006

Funchal, March 2007

Centro de Química da Madeira



The research unit has financial support from:

FCT Research Unit Number: 674

© CQM - Centro de Química da Madeira –University of Madeira – Funchal – Portugal - http://cqm.uma.pt - 2 -




Table of Contents

Chapter Page

1. Summary

Overview

Summary of the most important activities

Outlook

4

4

6

2. Unit identification 8

3. Research team 9

4. Scientific report

Research activities

Scientific projects and contracts

Organised meetings, conferences and short courses

Visiting fellows

Stays in other research centres

Other activities by team member

Awards and other merits

Main collaborations

12

13

20

20

21

21

22

23

5. Indicators 24

6. Publications

Papers

Proceedings

Popular press articles and newspaper interviews

Abstracts in scientific meetings

Science divulgation communications

25

29

29

29

33

7. Funding 34

8. Main supporters 35

9. Annexes 36




1. Summary

1.1 OVERVIEW

Centro de Química da Madeira (CQM) was officially created in 2004 with the approval of a proposal,

submitted in 2002, to the Fundação para a Ciência e a Tecnologia (FCT) by a group of five (5) Ph. D.

researchers from the Chemistry Department of the University of Madeira (UMa). Its stated mission is

devoted to the development of R&D activities in the field of Chemistry in Madeira Island, promoting

simultaneously the post-graduation formation, the collaboration with other national and international

research unities, the services to the community and the awareness of science among youngsters and

the society in general. The research centre is organized in two research lines: Natural Products and

Materials. Currently, our research team is composed by 9 permanent Ph. D. members from two

Departments: Chemistry and Health Sciences, 5 Post-docs, 6 Ph. D. students, 6 collaborators and

several undergraduate and graduate students and one administrative staff member.

The ongoing research projects represent a total of €1.1 millions. This sum, along with previous

financed projects, amount more than €2.6 millions (considering the budget of all partners involved).

Besides, CQM participates in the national networks of NMR and MS with a national budget of €9.8

millions. Research projects are directed towards applied research with high local impact (evaluation

and improvement of Madeira wine; chemical characterization and pharmaceutical potential of products

extracted from endemic plants) and also directed to most emergent and demanding fields (design and

synthesis of drugs from bioactive natural analogues; gene delivery; tissue engineering; molecular

modeling; and nanochemistry with electronic and biomedical applications).

1.2 SUMMARY OF THE MOST IMPORTANT ACTIVITIES

This report describes the activities carried out at the CQM during the year of 2006, the third year

covered by the financial support of FCT. The report reflects an intensive work developed in terms of

publications, preparation of research projects, consolidation or establishment of collaborations,

recruitment of Ph. D. and Post-doc students as well as scientific divulgation actions.

The CQM had, during 2006, 29 research projects funded by different entities like FCT and INTERREG

IIIB, and awaits the evaluation outcome of 6 submitted projects accounting about €989.500. The

University of Madeira (UMa) created funds to promote research, and CQM obtained incentives

corresponding to 30 % of the total available amount.




Regarding the scientific production, 23 papers and 1 proceeding were published, and 7 other papers are

already accepted for publication. Additionally, 16 oral communications and 41 posters were presented

at scientific Meetings and Conferences.

In 2006, CQM continued the intensive work of recruiting Ph. D and Post-doc fellows started in 2004. Out

of 6 Ph. D and 4 Post-doc proposals submitted to the FCT, 5 were approved. As a result, CQM now has 5

Post-docs and 6 Ph. D students. Another Post-doc will soon start working at CQM. Additionally, CQM has

coordinated, since 2005, a post-graduate course on Occupational Safety and Hygiene that had 28

students in 2006.

It is worth mentioning the several conferences where team members of CQM were present as

organizers (co-organizers or local organizers):

• the 1st Annual International Meeting of the Portuguese Society for Stem Cells and Cellular

Therapies

• the 1st Marie Curie Cutting Edge InVENTS Conference on New Developments on Polymers for

Tissue Engineering, Replacement and Regeneration

• the 4th International Symposium of the Portuguese Society for Metabolic Diseases

• 1st Meeting YBIM Young BioMedical Investigators of the Macaronesia

Other three international meetings/advanced training schools are currently under preparation to be

held in 2007.

In 2006, CQM has also received the visit of three visiting felows:

• Prof. Kari Rissanen from the NanoScience Center/Univ. de Jyvaskyla (Finland) that stayed with

us during one week for discussion of research work with Prof. João Rodrigues and to give an

advanced training course on Supramolecular Chemistry

• Dr. Lucina Sousa, from UNESP/Brasil, that stayed during 4 months, in the framework of her

Ph.D. work, under the supervision of Prof. Helena Tomás

• Prof. José M. Padrón from BioLab, Instituto Canario de Investigación del Cáncer Instituto

Universitario de Bio-Orgánica "Antonio González"/Universidad de La Laguna, to develop

research work with Prof. Paula Castilho and to present an invited talk

CQM current activities also include initiatives that have the objective of promoting the awareness of

science among youngsters. Two main projects were deployed in this area: “A Química é

Divertida/Chemistry is Fun” (several chemistry/biochemistry related activities performed during 1

week), both funded by Agência Nacional para a Cultura Científica e Tecnológica (ANCCT) - Ciência Viva

and “Ocupação Científica de Jovens nas Férias”. Furthermore, CQM publishes the newsletter




“Memento”, maintains CQM´s website (50 accesses/day in 2006) and has a regular service of press

releases. As a result, often makes the news in the regional media. At the least, 10 short news and 3 big

interviews (4 coloured pages in the Sunday newspaper supplement of “Diário de Notícias da Madeira”)

were published in 2006. The total estimated time spent by the local TV station with information about

CQM´s activities, in 2006, was about 5 min in prime time news.

The recognition of the merits of CQM members was also shown by the appointment of Prof. Pedro Pires

as a National Expert attached to the European Commission in Brussels (Unit of Micro and Nanosystems)

and by the invitation of Prof. João Rodrigues to stay, as a visitant professor at the NanoScience Center

(Univ. de Jyvaskyla, Finland).

Due to the growth of CQM during the period 2004-2006 a reorganization is being implemented to

strengthen the internal (in UMa) and external image of CQM, establish internal and external

collaborations, increase the engagement of regional entities in CQM projects and explore at the

maximum the potential uses of our new equipments (NMR and LCMSMS). In this scope, a portfolio of

services readily available for the regional community is under preparation. The creation of five (5)

Research and Development Labs (the Biomaterials and Tissue Engineering Lab, the Coordination

Chemistry and Molecular Materials Lab, the Enology and Analytical Chemistry Lab, the Molecular

Modeling Lab and the Organic Chemistry and Natural Products Lab) inside CQM is also already being

implemented.

1.3 OUTLOOK

The trajectory followed so far confirm the statement made by the evaluation panel of the proposal

presented by CQM to the National Program for Re-Equipment; the panel described CQM as “… a good

group that deserves support now. This project is very good and needs to be supported in the frame of a

general policy which will recognize the national interest to provide the Madeira Chemistry with large

equipment.”. In fact, we believe that his report reveals a potential for growing (both scientifically and

in what concerns the relations with the surrounding society) in the next years. This will certainly be

reinforced with the availability, in 2007, of the new “big” equipments attributed to CQM (NMR and

LCMSMS).

However, for the concretization of such growth during 2007 and the following years, we are aware

that we must:

• Consolidate the areas of intervention of the Research labs

• Actively search and establish partnerships with groups and institutions that complement the

activities of the existing Labs and groups at CQM (in Portugal and abroad)

• Reinforce the scientific cooperation between members of CQM




• Get support (from FCT and from other institutions) for the regular maintenance of the new

equipments (NMR and LCMSMS)

As our main goals we want to:

• Raise our number of papers by year. An average of two (2) papers/Ph. D./year should be our

target for the next years (2006: 1.6 paper/Ph. D.)

• Raise our average impact factor (2006: 2.0 (21 publications with impact factor in 23 published

papers); 2005: 1.9 (7 publications); the average impact factor of our University in 2006 was 1.4

• Reinforce the engagement with regional entities and private companies

• Reinforce the critical mass in terms of human resources and equipments

• Organize advanced training programs together with other national and international institutions

in the field of Natural Products and Materials

• To have the resources to hire an NMR expert to reinforce our research staff

Finally, we hope that the activities described in this report and the new phase of development to be

achieved with the installation, during 2007, of the NMR and LCMSMS equipments will convince the

funding entities, namely FCT and UMa, to continue their support to the CQM. Only with that we will be

able to pursuit our mission.




2. Unit identification

Research Unity


Cientific Domain

Chemistry

Scientific Coordinator

João Manuel Cunha Rodrigues

Research Unity Address

Departamento de Química da Universidade da Madeira, Campus Universitário da Penteada

9000-390 Funchal

Phone Fax

00351 291705100 00351 291705149

E-mail URL address

[email protected] http://cqm.uma.pt

Host Institution

Universidade da Madeira

Largo do Município - Colégio dos Jesuítas

9000-081 Funchal

NIF: 680041982

Management Institution

Universidade da Madeira

Largo do Município - Colégio dos Jesuítas

9000-081 Funchal

NIF: 680041982

Research Lines

Natural Products

Materials

Keywords

Enology

Phitochemistry

Materials

Biomaterials



3. Research team

At the end of 2006, the CQM was constituted by 14 Ph. D. members, one more than in 2005 (Table 1

and 2), 6 Ph. D. students (Table 2), 6 co-workers, several undergraduate and graduate students (Table

3) and one administrative staff member in a total of 31 team members. 5 of the Post-docs and 4 Ph. D.

students were directly financed trough FCT fellowships. Two of the collaborators (also former students

of the Chemistry Department/UMa) continue their studies outside Madeira: one is doing the Ph. D. at

the University of Bordeaux (France) and the other is a Master student at the University of Lisbon.

Due to the results of the Post-doc and Ph D. grant proposals as well as the CQM recruitments strategy,

together with the installation of the NMR and LCMSMS during the year of 2007, we expect to increase

the number of Ph. D. members by, at least, two and the Ph D. student’s number by three.

Figure 1. Part of the CQM team during the 1st Materials Line Meeting

CQM FOUNDATION BOARD (2002-2003)

José Carlos Marques (Ph. D.)

Paula Castilho (Ph. D.)

Helena Tomás (Ph. D.)

João Rodrigues (Ph. D.)

José Carlos Mesquita (Ph. D.)





Table 1. CQM full members and administrative staff

Name Situation Position % time Eligible part

Helena Maria Pires Gaspar Tomas Ph. D. Assistant Professor 60 1,00

Helena Paula de Freitas Caldeira Araújo Ph. D. Assistant Professor 60 1,00 João Manuel Cunha Rodrigues Ph. D. Assistant Professor 60 1,00 José Carlos Almeida Mesquita Ph. D. Assistant Professor 60 1,00 José Carlos Antunes Marques Ph. D. Associated Professor 60 1,00 José de Sousa Câmara Ph. D. Assistant Professor 60 1,00

Miguel Xavier Jesus Josefat Fernandes Ph. D. Assistant Professor 60 1,00

Paula Cristina Machado Ferreira Castilho Ph. D. Associated Professor 60 1,00 Pedro Filipe Duarte Louzeiro PiresPh. D. Assistant Professor 60 1,00 César Esmeraldo Fernandes PAPCC Assistant 100 0,00 Ana Maria Pereira Fraguas Mota BSc(Hons) Administrative officer 50 0,00

Maria Helena da Silva Oliveira Figueira da Silva BSc(Hons) Invited Assistant 60 0,00




Table 2. Research students

Name Situation Grant % time Eligible part

Agata Renata Czardybon Ph. D. Post-doc fellow, FCT 100 1,00 Cezar Florin Catrinescu Ph. D. Post-doc fellow, FCT 100 1,00 Visvaldas Kairys Ph. D. Post-doc fellow, FCT 100 1,00 Wojciech Czardybon Ph. D. Post-doc fellow, FCT 100 1,00 Zsolt Csok Ph. D. Post-doc fellow, FCT 100 1,00

Carla Sophia Brazão Andrade Sousa Alves MSc. Ph. D. grantee, FCT 100 0,00

Tatiana de Souza Weinhold MSc. Ph. D. grantee, INTERREG IIIB 100 0,00

Ana Lina Fernandes BSc(Hons) Grantee, INTERREG IIIB 100 0,00

João Luís Camacho Baptista Figueira BSc(Hons)

Grantee, POCTI Programme, FCT 100 0,00

Jose Luis da Silva Santos BSc(Hons) Ph. D. grantee, FCT 100 0,00 Marisela Cátia Fernandes Pontes BSc(Hons) Grantee, INTERREG IIIB 100 0,00

Sandra Cristina Gonçalves Gouveia BSc(Hons) Ph. D. grantee, FCT 100 0,00 Vanda Nulita Gomes Pereira BSc(Hons) Ph. D. grantee, FCT 100 0,00

Table 3. Co-workers

Name Situation Position % time Eligible part

Maria do Ceu Goncalves da Costa Ph. D. Researcher 40 0,00

Pedro Luis Ryberg Mousinho Figueiredo Ph. D. Other 40 0,00 Catia Cristina Capelo Ornelas BSc(Hons) Ph. D. grantee, FCT 20 0,00

Manuel Gonçalves Jardim Undergraduate student Other 100 0,00

Maria Elena Gonçalves Oramas BSc(Hons) Other 100 0,00 Rosa Maria De Sá Perestrelo BSc(Hons) Grantee, INTERREG IIIB 60 0,00



4. Scientific report

4. 1 RESEARCH ACTIVITIES

This section of the report mentions the activity implemented in 2006 by the CQM team members,

projects submitted and under way, advanced training (Ph. D. and Post-doc projects), visiting fellow

and main national and international collaborations.

Considering the importance to the future of the research center, the following items can be

highlighted:

• The number of papers published and oral presentations in national and international meetings

• The arrival of the 400 MHz NMR equipment at 28 of December (see Figure 2)

• The number of Post-docs and Ph. D. proposals submitted and approved

• The amount of research projects submitted for external funding and the approving by the

Agência Nacional para a Cultura Científica e Tecnológica (ANCCT) – Ciência Viva of the

divulgation science project “ A Química é Divertida/Chemistry is Fun”

Figure 2. 400 MHz Bruker Advance II+ NMR installed at CQM (National network

REEQ/1517/RMN/2005 – FCT National Programme for the Renewal of Scientific Equipment)





4. 2 SCIENTIFIC PROJECTS AND CONTRACTS

Currently the researchers of CQM are involved in 29 research projects, 17 funded by FCT (including 2

infra-structural projects – RMN and LCMSMS equipments, 6 Ph. D and 5 Post-doc research projects), 2

by the European Union Program INTERREG IIIB, 2 by the Agência Nacional para a Cultura Científica e

Tecnológica (ANCCT), 1 by the Agência de Inovação (AdI), 1 by the GRICES and 6 supported by

University of Madeira through the funds to promote research, supported by Totta & Açores/Santander

bank. 6 research projects were submitted for evaluation by the FCT in the last call. One is already

approved for financial support.

COMMON PROJECTS:

1. “CHEMIA-CHEMISTRY ENHANCEMENT IN MADEIRA BY INSTRUMENTAL ANALYSIS”. Submitted by

CQM-Centro de Química da Madeira – Universidade da Madeira to the National call for funding

"Programa de Re-Equipamento Científico" launched by FCT, EEQ/876/2001, 2004-Approved. Based in

this proposal, CQM is currently part of two national networks, one in the field of NMR

(REEQ/1517/RMN/2005; CQM: €278.000) and other in the field of Mass Spectrometry

(REEQ/1508/REM/2005; CQM: €168.000).

2. In 2006 CQM received, from the first time, the support of Agência Nacional para a Cultura

Científica e Tecnológica (ANCCT) - Ciência Viva for the divulgation science project “A QUÍMICA É

DIVERTIDA/CHEMISTRY IS FUN” that is usually developed during the National Week for Science and

Technology: Funding approved: €18.200, POCI 43-2006, 2006-2008. Coordinator: Helena Tomás

(SCIENTIFIC DIVULGATION ACTION)

3. CQM, together with the Chemistry Department, was involved in the project “Ocupação Científica

dos Jovens nas Férias”, held in July and supported by ANCCT - Ciência Viva with €1675, 12 high school

students participated in research activities during two weeks. Coordinator: Helena Tomás. (SCIENTIFIC

DIVULGATION ACTION)




RESEARCH PROJECTS SUBMITTED FOR EXTERNAL FUNDING

SUBMITTED TO FCT:

1. “BONEGENE - BONE TISSUE ENGINEERING BY GENE DELIVERY IN THREE-DIMENSIONAL

STARCH-BASED POLYMERIC SCAFFOLDS”. Funding requested to FCT: €196.500. Proponent

institution: UMa; Participant institution: Univ. Minho (3B´s Research Group).

PTDC/BIO/67169/2006, 2007-2010. Principal Investigator: Helena Tomás (in re-evaluation)

2. “COMPUTER AIDED MOLECULAR MODELING OF PHOSPHODIESTERASE 3 INHIBITORS”. Funding

requested to FCT: €100.000 Proponent institution: UMa. PTDC/BIA-PRO/73128/2006, 2007-

2010. Principal Investigator: Miguel Fernandes (in evaluation)

3. “DENDRALGENE - DESIGN OF NEW GENE DELIVERY VECTORS BASED ON DENDRIMERS,

ALGINATE AND THE RGD SEQUENCE FOR BONE TISSUE ENGINEERING”. Funding requested to

FCT: €200.000. Approved by FCT: €175.000. Proponent institution: UMa. PTDC/SAU-

BEB/71161/2006, 2007-2010. Principal Investigator: Helena Tomás (Approved)

4. "DESIGN OF SELECTIVE INHIBITORS FOR HUMAN PRO-COAGULANT PROTEASES". Funding

requested to FCT: €120.000. Proponent institution: UMa. PTDC/BIA-PRO/72540/2006,

2007-2010. Principal Investigator: Miguel Fernandes (in evaluation)

5. “DOENÇA VASCULAR: AVALIAÇÃO DE FACTORES DE RISCO E DE BIOMARCADORES COM EFEITO

PROTECTOR”. Funding requested to FCT: €183.927. Proponent institution: CITMA.

PTDC/SAU-ESA/69070/2006, 2007-2010. Principal Investigator: Helena Caldeira (in

evaluation)

6. “FUNCMETAL-FUNCTIONALIZED METALLODENDRIMERS BASED ON 2,4,6-TRI-SUBSTITUTED-

1,3,5-TRIAZINE CORE DERIVATIVES”. Funding requested to FCT: €188.981. Proponent

institution: UMa. PTDC/QUI/64202/2006, 2007-2010. Principal Investigator: João Rodrigues

(in evaluation)

SUBMITTED TO OTHER INSTITUTIONS:

1. “BIOTIP-SELECTED PEPTIDE SEQUENCE FOR ACTIVE FUNCTIONALIZED AFM-TIP”,

Transnational Call for Collaborative Projects 2006, NanoEra - Letter of intention, Project

involving 5 European research groups from France, Portugal, Finland, UK and Spain.

Submitted in May 2006, not selected for evaluation due to the technical reasons. Team

member: João Rodrigues

2. “DESIGN, ISOLATION, SYNTHESIS AND EVALUATION OF ANTITUMORAL COMPOUNDS OF

NATURAL ORIGIN”, (4 partners) submitted to Fundação J.B. Fernandes Memorial Trust:

Proponent institution UMa. Participant institutions: Instituto Canário de Investigacion en




Cancro, Centro Hospitalar do Funchal. Principal investigator: Paula Castilho (in evaluation)

PROJECTS UNDER WAY OR CONCLUDED IN 2006:

1. “ANTIVINMAC - DETERMINAÇÃO DO TEOR DE POLIFENÓIS, AMINOÁCIDOS E AMINAS

BIOGÉNICAS EM VINHOS DE CASTAS COMUNS AOS AÇORES, CANÁRIAS E MADEIRA”. Funded by

FEDER – INTERREG IIIB, Total: €520.000; CQM partner: €220.000; 2005-2006. Principal

Investigator: José Câmara

2. “BIOPOLIS – BUILDING AN EUROPEAN BIOREGION”. Funded by FEDER – INTERREG IIIB –

05/MAC/2.3/C14, 5 partners, €708.000; 2006-2007. CQM partner: €176.000. Team

member: Paula Castilho

3. "CARACTERIZAÇÃO ESTRUTURAL POR DIFRACÇÃO DE RAIOS-X”. Submitted by Centro de

Química Estrutural do IST to "Programa de Re-Equipamento Científico" launched by FCT,

2001 (2004-Approved). Team member: João Rodrigues

4. “CLAYCATS - MODIFIED PORTO SANTO CLAYS AS CATALYSTS FOR LIQUID PHASE ORGANIC

REACTIONS” with the Materials Research Institute, Sheffield Hallam Univ, UK, and Évora

University, Portugal. Funding requested to FCT €100.000. Approved by FCT: €72.000.

POCTI/CTM/47619/2002, 2004-2006. Principal Investigator: Paula Castilho

5. “IMPACT- IMPACTO DAS TECNOLOGIAS DE PRODUÇÃO NA QUALIDADE DO VINHO MADEIRA”

(AdI). Funding requested: €196.934. Approved by ADI: €134.722. Concluded in July 2006.

Team member: José Carlos Marques

6. “MOLECULAR INTERACTIONS IN LIQUIDS AND LIQUID MIXTURES”. Funding requested to FCT:

€76.500. Approved by FCT: €72.000. POCTI/EQU/60963/2004. Principal Investigator:

Pedro Pires

7. "NOVEL POLARISED MOLECULAR WIRES BASED ON TRANSITION METAL COMPLEXES OF DI(4-

PYRIDYL) HETEROCYCLES SPACERS BRIDGING LIGANDS". Funding requested to FCT: €85.710.

Approved by FCT: €85.710. POCTI/CTM/41495/2001, 2003-2007. Starting date: 1/4/2003.

Principal Investigator: João Rodrigues

8. “REGULARITY AND STABILITY OF ORDERED MESOPOROUS MATERIALS CONTAING ALUMÍNIUM

AND TITANIUM” - with Évora Univ. (leader) and ITN and IST, Lisbon. Funding requested to

FCT €100.000. Approved by FCT: €93.000. POCTI/CTM/45859/2002, 2004-2006. Team

member: Paula Castilho

9. "CONSTRUÇÃO E CARACTERIZAÇÃO DE DENDRÍMEROS ORGANOMETÁLICOS PARA APLICAÇÕES

EM ÓPTICA NÃO LINEAR", BILATERAL PROJECT. Approved to the PROGRAMA PESSOA 2005-




2006 -Acções integradas LUSO-FRANCESAS -GRICES - EGIDE, with the Groupe de

Nanosciences Moleculaires et Catalyse of Prof. Dider Astruc, University of Bordeaux I,

France. €1910. Coordinator in Portugal: João Rodrigues

10. “ACFA – APOIO AO CONTROLO DE FABRICO DE PRODUTOS ALIMENTARES”, Universidade da

Madeira (UMa). Funding through UMa – Apoio à investigação Fundo B. Funding requested to

UMa: €2000. Approved by UMa: €576; Covered period: 2007. Principal Investigator: José

Carlos Marques

11. “CONFORMATIONAL DYNAMICS OF THE CELL-PENETRATING PEPTIDE, PEP-1, IN MEMBRANE

MODEL SYSTEMS: COMPUTATIONAL SIMULATION AND SPECTROSCOPIC STUDIES”, Universidade

da Madeira (UMa). Funding through UMa –Apoio à Investigação Fundo B/UMa. Funding

requested to UMa: €2000. Approved by UMa: €576. Covered period: 2007. Principal

Investigator: Miguel Fernandes

12. “PASE – PROJECTO DE ALTERAÇÃO DO SISTEMA DE ESTAMPAGEM NA INDÚSTRIA DE BORDADO

DA MADEIRA”, Universidade da Madeira (UMa). Funding through UMa – Apoio à Investigação

Fundo B/UMa. Funding requested to UMa: €2000. Approved by UMa: €634; Covered period:

2007. Principal Investigator: José Carlos Marques

13. “Pt(II) AND Pd(II) METALLOMOLECULAR WIRES USING 1,4-DIETHYNYLBENZENE DERIVATIVES

AS SPACERS LIGANDS”, Universidade da Madeira (UMa). Funding through UMa – Apoio à

Investigação Fundo B/UMa. Funding requested to UMa: €2000. Approved by UMa: €761;

Covered period: 2007. Principal Investigator: João Rodrigues

14. “SYNTHESIS OF A NEW METALLODENDRIMERS FAMILY USING RUTHENIUM, PLATINUM AND

PALLADIUM COMPLEXES AS BUILDING BLOCKS”, Universidade da Madeira (UMa). Funding

through UMa –Apoio à Investigação Fundo B/UMa. Funding requested to UMa: €2000,

Approved by UMa: €761; Covered period: 2007. Principal Investigator: João Rodrigues

15. "USE OF ORGANO-SILICON DENDRIMERS IN GENE THERAPY", Universidade da Madeira (UMa).

Funding through UMa – Apoio à Investigação Fundo B/UMa. Funding requested to UMa: €

2000. Approved by UMa: €634; Covered period: 2006. Principal Investigator: Helena Tomás

OTHER PROJECTS:

1. “BILATERAL AGREEMENT SOCRATES”, programme: HIGHER EDUCATION (ERASMUS) 2003-

2006- student and teaching staff mobility:

• UNIVERSITÉ BORDEAUX I, France – Metallodendrimers – Prof. Didier Astruc

• UNIVERSITY OF JYVÄSKYLÄ, Finland – Dendrimers – Prof. Kari Rissanen

Coordinator in Portugal: João Rodrigues




Ph. D. AND POST-DOC PROJECTS UNDER WAY OR CONCLUDED IN 2006:

Ph. D. Projects

1. “ARGILAS PILARIZADAS COMO CATALISADORES ÁCIDOS SÓLIDOS”, Ph. D. Project developed

by Dr. César Fernandes. PRODEP Funded. Supervisor: Paula Castilho with the co-supervision

of Chistopher Breen (Materials Research Institute, Univ. Sheffield Hallam, UK).

2. “AVALIAÇÃO FITOQUÍMICA E FARMACOLÓGICA DE ALGUMAS PLANTAS AROMÁTICAS DA

FAMÍLIA DAS LABIATAE”, Ph. D. Project developed by MSc. Tatiana Weinhold. FEDER –

INTERREG IIIB 05/MAC/2.3/C14. Supervisor: Paula Castilho

3. "BONE TISSUE ENGINEERING VIA LOCAL GENE DELIVERY", Ph.D. project developed by Dr. José

Luís Santos. Ph. D. Grant SFRH/BD/19450/2004/NG2H. Started in February 2005. Supervisor:

Helena Tomás with the co-supervision of Pedro Granja (INEB)

4. “HEATING EFFECT IN THE FORMATION OF TYPICAL AROMA COMPOUNDS PRESENT IN MADEIRA

WINES”, Ph. D. project developed by Dr. Vanda Nulita Gomes Pereira, Ph. D. Grant

SFRH/BD/24177/2005. Started in February 2006. Supervisor: José Carlos Marques

5. "ISOLAMENTO E CARACTERIZAÇÃO DE PRINCÍPIOS ACTIVOS DE PLANTAS PARA O COMBATE À

TUBERCULOSE", Ph. D. project developed by Dr. Sandra Cristina Gonçalves Gouveia. Ph.D.

Grant SFRH/BD/24227/2005. Started in February 2006. Supervisor: Paula Castilho

6. “SPECTROSCOPIC AND COMPUTATIONAL STUDIES OF THE MECHANISM OF ACTION OF CELL

PENETRATING PEPTIDES”, Ph. D. project developed by Dr. Carla Sophia Alves. Ph. D. Grant

SFRH/BD/24547/2005. Evaluation: 4.4; minimum 4.4. Started in February 2006. Supervisor:

Miguel Fernandes

Post- Doc Projects

1. "DEVELOPMENT OF A NOVEL FAMILY OF Pt (II) AND Pd(II) METALLOMOLECULAR WIRES USING

1,4-DIETHYNYLBENZENE DERIVATIVES AS SPACERS LIGANDS". Post-doc project developed by

Dr. Wojciech Czardybon (Silesian University of Technology, Gliwice, Poland). Post-doc Grant

SFRH/BPD/20695/2004. Work in collaboration with Prof. Miguel Fernandes, Centro de

Química da Madeira. From October 2005 to September 2008. Evaluation: 4.4; minimum 4.1.

Supervisor: João Rodrigues

2. “INTEGRATION OF GENOMIC AND STRUCTURAL INFORMATION TO CHOOSE NEW

THERAPEUTICAL TARGETS AND DEVELOP NEW DRUGS AGAINST MALARIA”. Post-doc project

developed by Dr. Visvaldas Kairys. Post-doc Grant SFRH/BPD/20716/2004. From June 2005




to 2008. Evaluation: 4.5; minimum 4.1. Supervisor: Miguel Fernandes

3. “HEMISYNTHESIS OF FINE CHEMICALS FROM NATURAL TERPENES USING MODIFIED PORTO

SANTO CLAYS AS CATALYSTS”, Post-doc project developed by Dr. Cesar Catrinescu. Post-doc

Grant FEDER – INTERREG IIIB 05/MAC/2.3/C14. From March 2006, in continuity of

POCTI/CTM/47619/2002. Supervisor: Paula Castilho.

4. “SYNTHESIS AND STRUCTURAL CHARACTERIZATION OF A NEW METALLODENDRIMERS FAMILY

USING RUTHENIUM, PLATINUM AND PALLADIUM COMPLEXES AS BUILDING BLOCKS”. Post-doc

Project developed by Dr. Zsolt Csók (Ph. D. in Chemistry by University of Veszprém

(Hungary), Post-doc Grant: SFRH/BPD/20663/2004. From October 2005 to September 2008.

Evaluation: 4.5; minimum 4.1. Supervisor: João Rodrigues

5. “EFFECT OF CHIRALITY ON THE CONDUCTIVITY EFFICIENCY OF METALLOMOLECULAR WIRES

BASED ON EDOT DERIVATIVES”. Dr. Agata Renata Czardybon (Silesian University of

Technology, Gliwice, Poland). Post-doc Grant: SFRH/BPD/26680/2005. From October 2006

to September 2008. Evaluation: 4.7; minimum 4.4. Supervisor: João Rodrigues

6. “HEMISYNTHESIS OF FINE CHEMICALS FROM NATURAL SUBSTANCES USING TITANIUM-MCM-41

AS CATALYSTS”. Post-doc project developed by Dr. Susana Ramos Post-doc Grant FEDER –

INTERREG IIIB 05/MAC/2.3/C14. From November 2006 to June 2007. Supervisor: Paula

Castilho

Ph. D. AND POST-DOC PROJECTS SUBMITTED TO FCT:

Ph. D. Projects

1. “APROVEITAMENTO DOS RESÍDUOS DAS INDÚSTRIAS DE FRUTOS PARA A PRODUÇÃO DE

BIOCOMBUSTÍVEIS”. Dr. Pedro Miguel Sena Costa Branco, Ph. D. Grant:

SFRH/BD/32334/2006. Evaluation: 4.4; minimum 4.4. Approved. Supervisor: Paula Castilho

with the co-supervision of Fernanda Rosa (INETI/Dep. de Energias Renováveis)

2. “CARACTERIZAÇÃO QUÍMICA E HIERARQUIZAÇÃO (POR QUIMIOTERAPIA) DOS AROMAS DE

ENVELHECIMENTO DE VINHOS FORTIFICADOS”. Dr. Ana Cristina Pereira. Ph. D. Grant:

SFRH/BD/28660/2006. Evaluation: 4.4; minimum 4.4. Approved. Supervisor: Pedro Saraiva

with the co-supervision of José Carlos Marques

3. “NEW METALLOMOLECULAR WIRES BASED IN OLIGOTHIOPHENE BRIDGING SYSTEMS - A

SYSTEMATIC STUDY”. Dr. João Luís Camacho Baptista Figueira (Universidade da Madeira).

Ph. D. Grant: SFRH/BD/29325/2006. Evaluation: 4.7; minimum 4.2. Approved. Supervisor:

João Rodrigues with the co-supervision of Kari Rissanen (NanoScience Center, Univ. of

Jyvaskyla, Finland)




4. “CARACTERIZAÇÃO DO PERFIL DAS FRACÇÕES, LIVRE E GLICOSILADA, DO AROMA VARIETAL DE

CASTAS PRODUTORAS DE VINHO DE MESA TERRAS MADEIRENSES”. Dr. Maria Carolina Duarte.

Ph. D. Grant Proposal: SFRH/BD/31288/2006. Evaluation: 3.6; minimum 4.2. Not Approved.

Supervisor: José Câmara

5. “CARACTERIZAÇÃO DO POTENCIAL ANTIOXIDANTE DOS VINHOS MADEIRA. AVALIAÇÃO DA SUA

IMPORTÂNCIA NA PREVENÇÃO DE DOENÇAS ATEROSCLERÓTICAS E NEURODEGENERATIVAS”.

Dr. Ana Sofia Róis. Ph. D. Grant Proposal: SFRH/BD/27387/2006. Evaluation: 3.8; minimum

4.3. Not Approved. Supervisor: José Câmara

6. “PERFIL DA COMPOSIÇÃO AZOTADA EM VINHOS MADEIRA. IMPLICAÇÕES MECANÍSTICAS E

PRINCIPAIS ETAPAS DE FORMAÇÃO”. Dr. Rosa Perestrelo. Ph D. Grant Proposal:

SFRH/BD/31160/2006. Evaluation: 3.5; minimum 4.2. Not Approved. Supervisor: José

Câmara

Post-doc Projects

1. “COMPUTATIONAL DESIGN OF HIV-1 INTEGRASE INHIBITORS USING AN IMPROVED MODEL FOR

CALCULATION OF BINDING AFFINITIES”, Dr. Farooq Kiani, Post-doc Grant:

SFRH/BPD/30789/2006. Evaluation: 4.4; minimum 4.4. Approved. Supervisor: Miguel

Fernandes

2. “DESIGN AND DEVELOPMENT OF PPAR-� SELECTIVE LIGANDS USING STRUCTURE BASED AND

LIGAND BASED COMPUTATIONAL APPROACHES”, Dr. Viney Lather, Post-doc Grant:

SFRH/BPD/30954/2006. Evaluation: 4.4; minimum 4.4. Approved. Supervisor: Miguel

Fernandes

3. “EFFECT OF CHIRALITY ON THE CONDUCTIVITY EFFICIENCY OF METALLOMOLECULAR WIRES

BASED ON EDOT DERIVATIVES”. Dr. Agata Renata Czardybon (Silesian University of

Technology, Gliwice, Poland). Post-doc Grant: SFRH/BPD/26680/2005. Evaluation: 4.7;

minimum 4.4. Approved. Supervisor: João Rodrigues

4. “INNOVATIVE SYNTHETIC METHODOLOGIES FOR THE PREPARATION OF SEMICONDUCTOR

NANOCRYSTALS (QUANTUM DOTS) FOR NONLINEAR OPTICAL APPLICATIONS”. Dr. Ley Wang

(Shandong University, China). Post-doc Grant Proposal: SFRH/BPD/31700/2006. Evaluation

4.2; minimum 4.4. Not approved. Supervisor: João Rodrigues

NETWORKS

1. “CYTED – Subprogramme X: Química Fina e Farmacêutica, Projecto X.9 Monografias De

Calidad, Seguridad Y Eficacia De Plantas Medicinales Iberoamericanas (Promfi)” 2002-2006

e Red X.A”, Red Iberoamericana de Productos Naturales de Uso Medicinal (RIPRONAMED),




2003-2006. Team member: Paula Castilho

2. “CYTED – Subprogramme X: Química Fina e Farmacêutica, Projecto X.11 Proyecto

Iberoamericano de Búsqueda y Evaluación de Agentes Naturales Antituberculosos

(PIBATUB)”, 2003-2007. Team member: Paula Castilho

In conclusion, the overall income arising from FCT programs and fellowships, INTERREG IIIB, AdI and

UMa is € 1.1 millions. A significant sum, considering the size of the research Centre and the facilities

available until the end of 2006.

4. 3 ORGANISED MEETINGS, CONFERENCES AND SHORT COURSES

• 1st Materials Line Meeting, Hotel Crown Plaza Madeira (Funchal, 27 of January of 2006)

• 1st Annual International Meeting of the Portuguese Society for Stem Cells and Cellular

Therapies, SPCE-TC (Funchal, 30/31 May 2006). Co-organizer

• 1st Marie Curie Cutting Edge InVENTS Conference on New Developments on Polymers for Tissue

Engineering, Replacement and Regeneration (Funchal, 1-5 June 2006). Local organizer

• 4th International Symposium of the Portuguese Society for Metabolic Diseases (Funchal, 24-25

November 2006). Local co-organizer

4.4 VISITING FELLOWS

• Dr. Lucina Sousa, from UNESP/Brasil, in the framework of her Ph.D. work; she developed a

project entitled “Cytocompatibility evaluation of the alloy Ti-6Al-7Nb after spark-anodization

surface treatment”, under the supervision of Prof. Dra. Helena Tomás. From September 2005 till

January 2006

• Prof. Kari Rissanen from NanoScience Center/Univ. de Jyvaskyla (Finland) stayed during one

week at CQM for discussion of research work and to give a short course on Self-Assembling

Supramolecules, Dendrimers, Molecular Machines and Muscles. From 29 of January till 4 of

February

• Prof. José M. Padrón from BioLab, Instituto Canario de Investigación del Cáncer Instituto

Universitario de Bio-Orgánica "Antonio González"/Universidad de La Laguna, from 29 October to 2




November Conference “Fe(III)-Promoted One-Pot Synthesis of Novel Marine Antiproliferative

Drug Analogs ”. 31 of October

4.5 STAYS IN OTHER RESEARCH CENTERS

• João Rodrigues (Ph. D.):

Visitant Professor at NanoScience Center/Chemistry Department of University of Jyväskyla

Finland. From 8 to 14 of April 2006, (SOCRATES/ERASMUS Programme);

Visitant Professor at Nanosciences and Catalysis Group - Université de Bordeaux I, France:

2006 (5-11 of June) (Pessoa Bilateral Agreement);

Invited Professor at NanoScience Center/Chemistry Department of University of Jyväskyla

Finland. From 25 of September to 15 of December 2006. Supported by the University of Jyväskyla

and by a Sabbatical Grant from FCT (FCT/BSAB/2006/632).

4.6 OTHER ACTIVITIES BY TEAM MEMBER

• João Rodrigues (Ph. D.):

Referee for Inorganic Chemistry Communications

Referee for Journal of Coordination Chemistry

Scientific Committee Member of the Fourteen International Conference on Composites/Nano

Engineering (ICCE-14), Boulder, USA, 2-8 July, 2006

Chairman of the Nano 1 Session in the Fourteen International Conference on Composites/Nano

Engineering (ICCE-14), Boulder, USA, 2-8 July, 2006

• Paula Castilho (Ph. D.):

Guest editor of Phytochemistry Reviews (2005-2007)

Scientific Committee Member of the 1st Young Biomedical Investigators Meeting, 9 and 10 of

November, 2006, University of La Laguna, Tenerife, Spain

Member of Committee of Honor of the 1º Encontro em Química Terapêutica:Medicinal

Chemistry for the 21st Century, 13/14 of October, Lisbon

Founder of the Portuguese Society for Phytochemistry and Phytotherapy, SPFITO

Representative of Portugal and Spain in the Large Committee of Phytochemical Society of

Europe (2005-2008)




• Miguel Fernandes (Ph. D.):

Referee for Biochemical Journal

Referee for Journal of Physical Chemistry B

Reviewer for the Health Research Board of Ireland

• Helena Tomás (Ph. D.):

Referee for Biomaterials

Local organizer of the 1st Marie Curie Cutting Edge InVENTS Conference on New Developments

on Polymers for Tissue Engineering, Replacement and Regeneration (Funchal, 1-5 June 2006). Local

organizer 1st Marie Curie Cutting Edge InVENTS Conference on New Developments on Polymers for

Tissue Engineering, Replacement and Regeneration (Funchal, 1-5 June 2006).

Co-organizer of the meeting: 1st Annual International Meeting of the Portuguese Society for Stem

Cells and Cellular Therapies, SPCE-TC, 30/31 May, Funchal.

• Helena Caldeira (Ph. D.):

Local organizer of the meeting: 4th International Symposium of the Portuguese Society for

Metabolic Diseases (Funchal, 24-25 November 2006).

4. 7 AWARDS AND OTHER MERITS

• Prof. Pedro Pires was appointed as National Expert assigned to the Unit of Micro and

Nanosystems of the DG Information Society (INFSO G2) European Commission, Brussels.

• Rosa Perestrelo won the National Prize “Young Enologist of the Year/Jovem Enólogo 2006",

from the Portuguese Association of Enology/Associação Portuguesa de Enologia.




4. 8 MAIN COLLABORATIONS

The research centre maintains a large number of collaborations with other institutions, private

companies and research groups at the national and international level, with an important background

in the respective fields, with the main objectives of exchanging expertise and students and, also, to

have access to equipments not available at our research centre and university.

• APRAM - Portos da Madeira • Direcção Regional da Agricultura • Direcção Regional de Saneamento Básico • Instituto do Vinho e do Bordado da Madeira • Jardim Botânico da Madeira • Madeira Wine Company • INEB • INETI • INFARMED • Instituto Superior de Agronomia • Instituto Superior Técnico • Faculdade de Ciências da Universidade de Lisboa • Universidade dos Açores • Universidade Católica Portuguesa • Universidade de Évora • Universidade do Porto • Universidade do Minho • Center for Advanced Research in Biotechnology (USA) • Institute of Physiology, Academy of Sciences of the Czech Republic • Instituto Politécnico Nacional (México) • Instituto Canario de Investigación del Cáncer (Spain) • Materials Res. Institute (Univ. de Sheffield Hallam, UK) • M-NIMBS, Michigan Nanotechnology Institute for Medicine and Biological Sciences (Univ. do

Michigan, USA) • NanoScience Center (Univ. de Jyvaskyla, Finland) • NEC – Corporation (Japan) • OC Centre for Innovation (Alberta, Canada) • UNIVALI (Brasil) • Universidade da Córsega (França) • Universidade de Antuérpia (Bélgica) • Universidade de Barcelona (Spain) • Universidade de Bordéus I (França) • Universidade de Graz (Áustria) • Universidade de Humboldt (Germany) • Universidade de La Laguna (Spain) • Universidade de Múrcia (Spain) • Universidade de Pisa (Italie)




5. Indicators

(Unit: numbers) 2006 Expected

2006 Achieved

2007 Expected

PUBLICATIONS 19 23 26 Books 0 0 0 Papers in internacional journals 19 23 25 Papers in national journals 0 0 1 COMMUNICATIONS 30 70 53 In internacional meetings 15 48 30 In national meetings 4 10 10 Reports 9 9 10 Organization of seminars and conferences 2 3 3 ADVANCED TRAINING 5 3 5 Ph. D. thesis 1 0 1 Master thesis 0 0 1 Others 4 3 3 OTHER INDICATORS 0 0 0 Models 0 0 0 Computational applications 0 0 1 Pilot plants 0 0 0 Prototypes 0 0 0 Patents 0 0 0 Others 0 0 0



6. Publications

During the year of 2006, the research center has published a total number of 23 papers and one

proceeding. Seven (7) more papers have already been accepted to be published in 2007 and other 12

papers were submitted by the end of 2006.

It is important to stress that in 2004, the first year of activity with financial support of FCT, the 9

eligible members of the team have published 7 papers in international journals (ca. 0.8 paper/team

member). In 2005, with a significant increase of the number of eligible members (13), we published 7

papers (ca. 0.5 paper/team member) and one proceeding. In 2006, and considering the team of 14

eligible members presented 23 published papers (an average number of ca. 1.6 paper/team members).

This increase in the number of publications in 2006 (with an average impact factor of 2.0) and in the

number of oral and poster presentations, respectively 16 and 41, reflects the huge effort that we have

done during the last years. Considering the number of publications from 2004 to 2006 a average of 12.3

papers/year or 1 paper/team member (average of 12 Ph. D./year) was achieved.

7 7

23

37

19

0

5

10

15

20

25

30

35

40

Num

ber o

f pap

ers

2004 2005 2006 TOTAL Accep./Sub.

Year

Figure 3. Evolution of the number of publications from 2004 to 2006

Currently, the installation of the NMR is under way and the process for the acquisition of the LCMSMS

will be launched very soon. We expect that the main effect of the existence of these equipments at

Centro Química da Madeira will be only visible in the next year (2008). According to this, our main

objective for the current year is to maintain or slightly increase the number of publications (25-30

papers) as well as to increase the average impact factor. This prevision is based on the number of

papers already accepted and submitted, as well as on the number of oral presentations and posters

presented during 2006.





PUBLISHED PAPERS IN INTERNATIONAL JOURNALS WITH IMPACT FACTOR (IF) 1. Câmara J.S., Alves M. A., Marques J.C.; Multivariate analysis for the classification and

differentiation of Madeira wines according to main grape varieties; Talanta; 68; 1512-1521; 2006 (IF: 2.391)

2. Câmara J.S., Alves M.A., Marques J.C., Changes in volatile composition of Madeira wines during their oxidative aging; Anal. Chim Acta; 563; 188-197; 2006 (IF: 2.76)

3. Câmara J.S., Alves M.A., Marques J.C.; Development of headspace SPME-GCMS methodology for analysis of terpenols in Madeira Wines; Anal Chim. Acta; 555; 191-200; 2006 (IF: 2.76)

4. Campo E., Ferreira V., Escudero A., Marques, J.C., Cacho J.; Quantitative gas chromatography-olfactometry and chemical quantitative study of the aroma of four Madeira Wines; Anal. Chim. Acta; 563; 180–187; 2006 (IF: 2.76)

5. Castanho M.A., Fernandes M.X.; Lipid membrane-induced optimization for ligand-receptor docking: recent tools and insights for the "membrane catalysis" model; Eur. Biophys J.; 35; 92-103; 2006 (IF: 1.811)

6. Catrinescu C., Fernandes C., Castilho P., Breen C.; Influence of exchange cations on the catalytic conversion of limonene over Serra de Dentro (SD) and SAz-1 clays: Correlations between acidity and catalytic activity/selectivity; Appl. Catal. A-Gen.; 311;172-184; 2006 (IF: 2.728)

7. Esperança, J. M. S. S., Pires, P. F., Guedes, H. J. R., Ribeiro, N., Costa, T., Aguiar-Ricardo, A.; Acoustic Determination of Thermophysical Properties and Critical Parameters for the Mixture (51 wt % R143a + 49 wt % R125) and Critical Line of xCO2 + (1 - x)(51 wt % R143a + 49 wt % R125); J. Chem. Eng. Data; 51; 2161-2169; 2006; doi: 10.1021/je060291c (IF: 1.61)

8. Esperanca, J. M. S. S., Pires, P. F., Guedes, H. J. R.; Ribeiro, N.; Costa, T.; Aguiar-Ricardo, A; Acoustic Determination of Thermophysical Properties and Critical Parameters for R404A and Critical Line of xCO + (1 - x)R404; 2 J. Chem. Eng. Data; 51; 1148-1155; 2006; doi: 10.1021/je0600707 (IF: 1.61)

9. Figueira J., Rodrigues J., Rissanen K.; trans-[bis(diphenylphosphino)methane-k2P,P']dichlororuthenium(II) dichloromethane disolvate; Acta Crystallogr. E; 62; m3594-m3596; 2006; doi:10.1107/S160053680605015X (IF: 0.581)

10. Kairys V., Fernandes M.X., Gilson M.K.; Screening drug-like compounds by docking to homology models: a systematic study; J. Chem. Inf. Model.; 46: 365-379; 2006 (IF: 2.923)

11. Macchioni F., Cioni P., Morelli I., Castilho P. C., Perrucci S.; Composition and acaricidal activity of Laurus novocanariensis and Laurus nobilis essential oils against Psoroptes cuniculi; J. Essent. Oil Res.; 18: 111-114; 2006 (IF: 0.367)

12. Mercimek-Mahmutoglu S., Stoeckler-Ipsiroglu S., Adami A., Appleton R., Caldeira Araújo H., Duran M., Ensenauer R., Fernandez-Alvarez E., Garcia P., Grolik C., Item C.B., Leuzzi V., Marquardt I., Mühl A., Saelke-Kellermann R.A., Salomons G., Schulze A., Surtees R., van der Knaap M.S., Vasconcelos R., Verhoeven N., Vilarinho L., Wilichowski E., Jakobs C.; GAMT deficiency: Features, treatment and outcome in an inborn error of creatine synthesis; Neurology; 67; 480-484; 2006 (IF: 4.947)

13. Méry D., Plault L.,. Ornelas C, Ruiz J., Nlate S., Astruc D., Blais J.C., Rodrigues J., Cordier S., Kirakci K., Perrin C.; From Simple Monopyridine Clusters [Mo6Br13(Py-R)6][n-Bu4N] and Hexapyridine Clusters [Mo6X8(Py-R)6][OSO2CF3]4 (X = Br or I) to Cluster-cored Organometallic Stars, Dendrons and Dendrimers; Inorg. Chem.; 45, 1156-1167; 2006; doi:10.1021/ic051680f (IF: 3.851)

14. Nascimento M.L., Mueller W.D., Carvalho A.C., Tomás H.; Electrochemical characterization of titanium biomaterials using the mini-cell system; J.Mater. Sci.; 41; 3323-3327; 2006 (IF: 0.901)

15. Ornelas C., Vertlib V., Rodrigues J., Rissanen K.; Ruthenium Metallodendrimers Based on Nitrile-

http://dx.doi.org/10.1021/je060291c

http://dx.doi.org/10.1107/S160053680605015X

http://dx.doi.org/10.1021/ic051680f




Functionalized Poly(alkylidene imine)s; Eur. J. Inorg. Chem.; 1, 47-50; 2006; doi: 10.1002/ejic.200500799 (IF: 2.514)

16. Perestrelo R., Marques J. C., Câmara J. S.; Analytical characterization of the Aroma of Tinta Negra Mole red wine. Identification of the main odorants compounds; Anal. Chim. Acta; 563; 154-164; 2006 (IF: 2.76)

17. Ribeiro, N., Costa, T., Aguiar-Ricardo A., Esperanca J. M. S. S.; Pires P. F., Guedes H. J. R.; Acoustic Determination of Thermophysical Properties and Critical Parameters for R410A and Critical Line of xCO + (1 - x)R410A2 .; J. Chem. Eng. Data; 51; 1906-1914; 2006; doi:10.1021/je060243s (IF: 1.61)

18. Russo L., Figueira J., Rodrigues J., Rissanen K.; cis-[Bis(diphenylphosphino)ethane-k2P,P']dichlororuthenium(II) dichloromethane disolvate; Acta Crystallogr. E; 62, m1154-m1155. doi:10.1107/S1600536806015005; 2006 (IF: 0.581)

19. Russo L., Figueira J., Rodrigues J., Rissanen K.; cis-Aquabis[bis(diphenylphosphino)ethane-k2P,P´]chlororuthenium(II) hexafluorophosphate dichlomethane sesquisolvate hemilydrate; Acta Crystallogr. E; 62, m699-m701.; 2006 doi:10.1107/S1600536806006921 (IF: 0.581)

20. Russo L., Nattinen K., Vertlib V., Rodrigues J., Rissanen K.; cis-Diazido[bis(diphenylphosphino)methane-k2P,P']ruthenium(II) dichloromethane 0.42-solvate; Acta Crystallogr E; 62, m2052-m2053; 2006; doi:10.1107/S160053680602900X (IF: 0.581)

21. Sedláková P., Svobodová J., Mikšík I., Tomás H.; Separation of poly(amidoamine) (PAMAM) dendrimer generations by dynamic coating capillary electrophoresis; J. Chromatogr. B; 841, 135-139; 2006 (IF: 2.391)

PUBLISHED PAPERS IN INTERNATIONAL JOURNALS WITH PEER REVIEW BUT WITHOUT IMPACT FACTOR 1. Catrinescu C., Fernandes C., Castilho P., Breen C., Carrot M.; Porto Santo clays as

environmentally friendly catalysts for the conversion of renewable terpene feedstocks. Limonene aromatization to p-cymene; Environmental Engineering and Management Journal; 5; 275-285; 2006

2. Kairys V., Gilson M.K., Fernandes M.X.; Using protein homology models for structure-based studies: approaches to model refinement; The Scientific World Journal; 6; 1542-1554; 2006

ACCEPTED PAPERS IN INTERNATIONAL JOURNALS (at the end of 2006) 1. Câmara J.S., Alves M.A., Marques J.C.; Classification of Boal, Malvazia, Sercial and Verdelho

wines based on terpenoid patterns; Food Chem. 101; 475-484; 2007 (IF:1.811)

2. Câmara J.S., Marques J.C., Perestrelo R.M., Rodrigues F., Oliveira L., Andrade P., Caldeira M.; Comparative study of the whisky aroma profile based on headspace solid phase microextraction using different fibre coatings; J. Chromatogr. A; 2007; doi:10.1016/j.chroma.2006.09.014; (IF: 3.096)

3. Castilho P., Liu K., Rodrigues A. I., Feio S., Tomi F., Casanova J.; Composition and antimicrobial activity of Clinopodium ascendens (Jordan) Sampaio from Madeira; Flavour Frag. J. 23; 139-144; 2007; doi:10.1002/ffj.1771; (IF: 0.718)

4. Fernandes C., Catrinescu C., Castilho P., Russo P.A., Carrott M.R, Breen C.; Catalytic conversion of limonene over acid activated Serra de Dentro (SD) bentonite; Appl. Catal. A-Gen.; 318; 108-120; 2007; (IF: 2.728)

5. Luna-Herrera J., Costa M., Gonzalez H., Rodrigues A., Castilho P.; Synergistic Antimycobacterial Activities of Sesquiterpene Lactones from Laurus spp; J. Antimicrob. Chemother.; 59; 548-552;

http://dx.doi.org/10.1021/je060243s

http://scripts.iucr.org/cgi-bin/paper?S1600536806015005

http://scripts.iucr.org/cgi-bin/paper?S1600536806006921

http://dx.doi.org/10.1107/S160053680602900X

http://dx.doi.org/10.1016/j.chroma.2006.09.014




2007; doi:10.1093/jac/dkl153; (IF: 3.886)

6. Nascimento M.L., Mueller W.D., Carvalho A.C., Tomás H.; Electrochemical characterization of cobalt-based alloys using the mini-cell system; Dent. Mater (in press), available online since 3 April 2006; doi: 10.1016/j.dental.2006.01.026; (IF: 2.056)

7. Vertlib V., Figueira J., Mesquita J., Rodrigues J., Nättinen K., Rissanen K.; A Trinuclear Aqua Cyano-bridged Ruthenium Complex [{(η5-C5H5)(PPh3)2Ru(μ-CN)}2RuCl2(PPh3)(H2O)][PF6]: Synthesis, Characterization and Crystal Structure; Eur. J. Inorg. Chem.; 2007; (IF: 2.514)

SUBMITTED PAPERS (at the end of 2006)

1. Caldeira Araújo H., Silva H., Ornelas R., Tomás H., Tavares de Almeida I., Duran M.; Uric acid and creatinine levels in two groups of school children; submitted to Pediatr. Nephrol. (IF: 1.62)

2. Caldeira Araújo H., Silva H., Tomás H., Tavares de Almeida I., Duran M.; A new solid-phase extraction procedure for purine and pyrimidine analysis; submitted to J. Chromatogr. B. (IF: 2.391)

3. Caldeira Araújo H., Tomás H., Silva S., Vasconcelos R., Smit W., Tavares de Almeida I., Duran M.; Urinary uric acid /creatinine ratio as a screening tool for creatine biosynthesis defects; submitted to Ann. Clin. Biochem. (IF: 1.25)

4. Câmara J.S., Marques J.C., Perestrelo R., Oliveira L., Rodrigues F., Caldeira M.; Volatile composition of whiskeys by different extraction methods. Evaluation of the main odour-active impact compounds; submitted to J. Chromatogr A; 2007 (IF: 3.096)

5. Castilho P.C., Gouveia S.C. Rodrigues AI; Quantitative Determination of Artemisinin in Artemisia annua extracts using 13C-NMR Spectroscopy; submitted to Phytochem Analysis, December 2006 (IF: 1.398)

6. Chellappan S., Kairys V., Fernandes M.X., Schiffer C.A., Gilson M.K.; Evaluation of the Substrate Envelope Hypothesis for Inhibitors of HIV-1 Protease; submitted to Proteins: Structure, Function, and Bioinformatics (IF: 4.684)

7. Chellappan S., Reddy K., Ali A., Altman M.D., Nalam M., Cao H., Kairys V., Fernandes M.X., Tidor B., Rana T., Schiffer C.A., Gilson M.K.; Design of Mutation-Resistant HIV Protease Inhibitors with the Substrate Envelope Hypothesis; submitted to Proteins: Structure, Function, and Bioinformatics; (IF: 4.684)

8. Kairys V., Fernandes M.X.; SitCon: binding site residue conservation visualization and protein sequence-to-function tool, submitted to Int. J. Quantum Chem. (IF: 1.192)

9. Lannang A.M., Ngninzeko F. N, Castilho P., Wansi J. D., Kuete V., Lontsi D., Beng V. P., Choudhary M.I., Sondengam B.L.; Securidacaxanthones B and C, xanthones from Securidaca longepedunculata (Polygalaceae); submitted to Phytochemistry; October 2006 (IF: 2.78)

10. Perestrelo R., Caldeira M., Rodrigues F., Oliveira L., Pereira V., Marques J.C., Câmara J.S.; Effect of ageing and heating process in minor volatile composition of Tinta Negra Mole red wines; submitted to Anal Chim. Acta, 2007 (IF: 2.76)

11. Tomás H., Fernandes L.F., Calabretta A., Pereira J.A., Costa M.A., Fernandes M.H.; Osteoblastic differentiation over an adsorbed collagen layer, over the surface of collagen gels and inside collagen gels – a comparative study; submitted to Calcified. Tissue Int. (IF: 2.487)

12. Tomás H., Fernandes L.F., Marques J.C., Costa M.A., Fernandes M.H.; Gel systems of collagen type I, proteoglycans and TGF-β1 – in vitro fibrillogenesis and growth factor release; submitted to J.Mater.Sci.Mater.M. (IF: 1.248)

http://dx.doi.org/10.1016/j.dental.2006.01.026




INTERNATIONAL PROCEEDINGS WITH PEER REVIEW 1. Rodrigues J., Csok Z., Czardybon W., Figueira J., Jardim M., Mesquita J., Garcia M. H., Robalo

M. P., Wenseleers W., Rissanen K.; Organometallic Materials for Photonics and Molecular Electronics Nanoscale Devices; Proceedings of Fourteenth Annual International Conference on Composites/Nano Engineering (ICCE-14); Boulder, USA, 2-8 July; 560-562; 2006

POPULAR PRESS ARTICLES AND NEWSPAPER INTERVIEWS 1. Castilho P.; Azeite de Louro potencial Medicamento; in Diário de Notícias (Madeira), 25 of June.

Newspaper interview.

2. Marques J.C.; Incentivar a Investigação na Região; NESI Webzine, April 5th

(http://noticia.nesi.com.pt/?p=159).

3. Marques J. C.; Na Rede Nacional de Investigação; in Diário de Notícias (Madeira), 29 of January. Newspaper interview.

4. Rodrigues J.; À Descoberta dos Nanomateriais; in Diário de Notícias (Madeira), 9 of July. Newspaper interview.

ABSTRACTS IN SCIENTIFIC MEETINGS ORAL COMMUNICATIONS 1. Caldeira Araújo H., Smit W., Verhoeven N.M., Salomons G., Silva S, Vasconcelos R., Tavares de

Almeida I., Jakobs C., Duran M.; Clinical outcome of four GAMT-deficient patients: a follow-up of four years; IV Simpósio Internacional da SPDM; Funchal, Portugal; November 2006

2. Caldeira M., Rodrigues F., Andrade P., Oliveira L., Perestrelo R., Marques J.C., Câmara J.S; Evaluation of volatile constituents profile in Scotch whisky by SPME/GC-ITMS;13th World Congress of Food Science & Technology – IUFost 2006; Nantes (France); September 2006

3. Castilho P., Gouveia S.; Rodrigues A.I.; Quantification of artemisinin in Artemisia annua extracts by 1H-NMR; Symposium in Antitumoral Natural Products, within the PSE Young Scientist Meeting; Olomouc, Czech Republic; 28 June - 1 July 2006

4. Castilho P.C.; Laurus spp fruit oil: new studies on its phytotherapeutic properties; University of Pisa, Department of Veterinary; 27 February 2006. (Invited Communication)

5. Csok Z., Jardim M., Mesquita J.C., Rodrigues J., Wenseleers W., Campo J., Rissanen K.; Synthesis and Structural Characterization of a New Family of Ruthenium Metallodendrimers With Potential Nonlinear Optical Applications; Annual Meeting of CQM/Materials Team; Funchal, Portugal; 27 January 2006

6. Czardybon W., Rodrigues J., Russo L., Rissanen K.; Synthesis and Characterization of a Novel Family of Pt (II) and Pd(II) Metallomolecular Wires; Annual Meeting of CQM/Materials Team, Funchal, Portugal; 27 January 2006

7. Figueira J., Rodrigues J., Russo L., Rissanen K.; Preparation of Ruthenium Molecular Wires Using 1,4-Diethynylbenzene Derivatives as Spacer Ligands; Annual Meeting of CQM/Materials Team; Funchal, Portugal; 27 January 2006

8. Jardim M., Rodrigues J., Ornelas C., Ruiz J., Astruc D.; Stepwise Construction of a Molecular Wire at Gold Surfaces Using an Acetylide Ruthenium Complex as Building Block; Annual Meeting of CQM/Materials Team; Funchal, Portugal; 27 January 2006

9. Kairys V., Fernandes M.X.; Molecular modeling of ligands: balancing specificity using computational methods; 1st Meeting of Young Biomedical Investigators in Macaronesia; Tenerife, Spain; November 2006

https://www.fct.mctes.pt/fctsig/contents/index.asp?area=3&object=44&formCommand=edit&formName=CVO_comunicacoes&key=66898








10. Kairys V., Fernandes M.X.; SitCon: Binding site residue conservation as a complementary tool to a sequence alignment; 6th European Conference on Computational Chemistry; Tale; Slovakia; September 2006

11. Perestrelo R., Pereira V., Marques J. C., Câmara J. S; Characterization of flavour composition and evaluation profile of TNM red wines by SPME-GCMS; 13th World Congress of Food Science and Technology; Nantes, France; September 2006

12. Rocha-Sousa L., Santos J. L., Pelláez-Abellán E., Guastaldi A.C., Tomás H.; Cytocompatibility modified by spark-anodization; 4º Congresso Latino-Americano de Órgãos Artificiais e Biomateriais; Caxambú; 2006

13. Rodrigues J., Csok Z., Czardybon W., Figueira J., Jardim M., Mesquita J., Garcia M. H., Robalo M. P., Wenseleers W., Rissanen K.; Organometallic Materials for Photonics and Molecular Electronics Nanoscale Devices; Fourteenth International Conference on Composites/Nano Engineering (ICCE-14); Boulder, USA; 2-8 July 2006. (Invited Communication)

14. Rodrigues J.; From Metallodendrimers for NLO to Molecular Wires for Nanoelectronic Applications; Centre de Physique Moléculaire Optique et Hertzienne; University of Bordeaux 1, France; 9 of June 2006. (Invited Seminary)

15. Tomás H.; Osteogenic differentiation - Extracellular Matrix Effects", Keynote Lecture; 1st Annual International Meeting of the Portuguese Society for Stem Cells and Cellular Therapies, SPCE-TC; Funchal; 2006

16. Tomás, H.; Tissue Engineering Research in Madeira – A Gene Delivery Approach; Keynote Lecture, 1st Marie Curie Cutting Edge InVENTS Conference on New Developments on Polymers for Tissue Engineering, Replacement and Regeneration; Funchal; 2006

POSTER COMMUNICATIONS 1. Alves C.S., Kairys V, Fernandes M.X.; Domain motions associated with substrate binding: the

relevance of distance matrixes; 1st Meeting of Young Biomedical Investigators in Macaronesia; Tenerife, Spain; November 2006

2. Andrade P., L. Oliveira, Caldeira M., Rodrigues F., Perestrelo R., Marques J.C., Câmara J.S; Method for the analysis of isoamyl esters and acetates in Scotch whiskeys by headspace sold-phase microextraction; 1st European Chemistry Congress, Budapest, Hungary; August 2006

3. Caldeira M., Rodrigues F., Andrade P., Oliveira L., Perestrelo R., Marques J.C., Câmara J.S; Analysis of whiskys aroma profile by solid phase microextraction using different fibres; 3th European Congress on Food; Sofia, Bulgary; May 2006

4. Caldeira M., Rodrigues F.; Oliveira L., Andrade P., Marques J.C., Câmara J.S.; Determination of major compounds in commercial whiskeys by HS-SPME and multidimensional chromatography; 29th International Symposium on Capillary Chromatograph; Riva del Garda, Italy; 29-2 June 2006

5. Caldeira M., Rodrigues F.; Oliveira L., Andrade P., Marques J.C., Câmara J.S.; Comparative study in the extraction yield of volatile constituents of whiskies using different extraction methods; 29th International Symposium on Capillary Chromatography; Riva del Garda, Italy; 29-2 June 2006

6. Câmara J.S., Perestrelo R., M. Arminda Alves, Marques J.C.; Chemical profile of the aroma compounds of Boal and Malvazia white wines; XXIXth World Congress of Vine and Wine; Logroño, Spain; 25-30 June 2006

7. Castilho P, Gouveia S., Liu K., Rodrigues A., Feio S., Felix T., Casanova J.; Clinopodium ascendens from Madeira. Chemical composition and bioactivity; International Symposium The Labiatae: Advances in Production, Biotechnology and Utilisation; San Remo, Italy; 22-25 February 2006




8. Castilho P.C., Correia D., Costa M.C., Rodrigues A.I., Branco P.C.; Costunolide and Dehydrocostuslactone as the Bioactive Components of Laurus novocanariensis fruit oil; 1º Encontro em Química Terapêutica da SPQ, Medicinal Chemistry for the 21st Century, Lisboa; 13-14 October 2006

9. Catrinescu C., Castilho P.C.; Fernandes C, Breen C.; Selective alkoxylation of limonene over commercially available clays; 1st International IUPAC Conference on Green-Sustainable Chemistry; Dresden, Germany; 10-15 September, 2006

10. Fernandes A. L., Câmara J. S., , Juan P. Perez, Marques J. C.; Evaluation of the free and glycosilated fractions of Boal and Malvazia grapes and wines; XXIXth World Congress of Vine and Wine; Logroño, Spain; 25-30 June 2006

11. Fernandes M., Pereira R., Câmara J.S., Marques J.C.; Madeira’s Table Wines: evolution and organoleptic characterisation; V World Wine Forum; Rioja, Spain; May, 2006

12. Gouveia, S. C., Castilho P.C., Weinhold, T.; Long Chain Alcohols from Origanum spp; 4th Spanish~Portuguese~Japanese Organic Chemistry Symposium (4SPJ-OCS); Book of Abstracts, 167; 8-11 September, 2006

13. Oliveira L., Caldeira M., Rodrigues F., Andrade P., Perestrelo R., Marques J.C, Câmara J.S; Chemical profiles of commercial whiskies by headspace solid-phase microextraction/gas chromatography-mass spectrometry analysis; 1st European Chemistry Congress; Budapest, Hungary; August 2006.

14. Paixão N., Pereira V., Perestrelo R., Marques J.C., Elias J., Câmara J.S.; Phenolic Composition of Madeira Table Wines; 13th World Congress of Food Science and Technology; Nantes, France; September 2006

15. Paixão N., Perestrelo R., Trujillo J.P., Marques J.C., Elias J., Câmara J.S.; Total oxidant capacity of Madeira wines; 3rd European Congress on Food; Sofia, Bulgaria; May 2006

16. Paixão N., Perestrelo R.,. Trujillo J.P, Marques J.C., Elias J., Câmara J.S.; Analysis of phenolic compounds with antioxidant properties in Madeira wines by high performance liquid chromatography; 13th World Congress of Food Science & Technology – IUFost 2006; Nantes, France; September 2006.

17. Paixão N., Perez J. P., Marques J.C., Elías J., Câmara J.S.; Determination of the antioxidant capacity of Madeira wines. Relation with the polyphenolic composition; XXIXth World Congress of Vine and Wine; Logroño, Spain; 25-30 June 2006

18. Pereira C., Costa S., Marques J.C.; Methodology for the analysis and control of hazards in solid waste treatment plants; 3rd International Conference Working on safety; De Eemhof, The Netherlands; September 2006

19. Pereira V., Albuquerque, Francisco M., Câmara J.S., Perez Juan P., Marques J.C; Levels of 5-Hydroxymethylfurfural (HMF) and furfural (F) in Madeira wines; XXIXthWorld Congress of Vine and Wine; Logroño, Spain; 25-30 June 2006

20. Pereira V., Perestrelo R., Câmara J.S., Ferreira A.C., Perez J.P., Marques J.C.; Effect of the heating step in the volatile composition of Madeira wines; 3th European Congress on Food, Sofia, Bulgary; May 2006.

21. Pereira V., Perestrelo R., Câmara J.S., Marques J.C; Chromatographic evaluation of the heating effect on the evolution of heterocyclic acetals present in Madeira wines; 29th International Symposium on Capillary Chromatography; Riva del Garda, 2006

22. Perestrelo R., Marques J.C., Câmara J.S.; Comparison of different solid-phase microextraction stationary phases for the analysis of major components in TNM red wines; 13th World Congress of Food Science & Technology - IUFost 2006; Nantes, France; September 2006.

23. Perestrelo R., Marques J.C., Câmara J.S.; Evaluation of carbonyl compounds during the heating




process of Tinta Negra Mole red wine; 29th International Symposium on Capillary Chromatography; Riva del Garda, Italy; 29-2 June 2006

24. Perestrelo R., Marques J.C., Câmara J.S.; Method for analysis of the volatile composition of Tinta Negra Mole red wine using gas chromatography-mass spectrometry; 29th International Symposium on Capillary Chromatography; Riva del Garda, Italy; 29-2 June 2006

25. Perestrelo R., Marques J.C., Câmara J.S; Evolution of higher alcohols and ethyl esters during the heating process of Tinta Negra Mole red wines; XXIXth World Congress of Vine and Wine; Logroño, Spain; 25-30 June 2006

26. Perestrelo R., Marques J.C., Câmara J.S.; Dynamic headspace solid-phase microextraction method development for the characterization of Tinta Negra Mole Red wines; 1st European Chemistry Congress; Budapest, Hungary; August 2006

27. Perestrelo R., Pereira V., Marques J.C., Câmara J.S.; Influence of the temperature and time on the profile of aroma components in tnm red wines by spme-gc/ms analysis; 3th European Congress on Food; Sofia, Bulgary; May 2006

28. Perestrelo R., Pereira V., Marques J.C., Câmara J.S.; Influence of the extraction temperature and time in the profile of aroma components of TNM red wines by SPME-GCMS analysis; 13th World Congress of Food Science & Technology - IUFost 2006; Nantes, France; September 2006.

29. Perestrelo R., Pereira V., Marques J.C.; Câmara J.S.; Comparison of different solid-phase microextraction sorbent stationary phases for analyzing the major volatile components in TNM red wines; 3th European Congress on Food; Sofia, Bulgary; May 2006

30. Perestrelo R., Pereira V., Marques J.C.; J.S. Câmara; Comparison of solid-phase microextraction and liquid-liquid extraction for the determination of the volatile composition of TNM wines; 1st

European Chemistry Congress; Budapest, Hungary; August 2006

31. Pimenta A., Gomes A., Araújo H.; GAMT Deficiency- GAMT Gene amplification from genomic DNA.; IV Simpósio Internacional da SPDM; Funchal; November, 2006

32. Rocha-Sousa L., Pelláez-Abellán E, Guastaldi A.C., Tomás H.; Cytocompatibility evaluation of a titanium alloy (Ti-6Al-7Nb) surface modified by spark-anodization; 1st Annual International Meeting of the Portuguese Society for Stem Cells and Cellular Therapies; SPCE-TC; Funchal, 2006

33. Rodrigues F., Andrade P., Oliveira L., Caldeira M., Perestrelo R., Marques J.C., Câmara J.S.; Identification of the key odorants in Scotch whiskeys samples; 1st European Chemistry Congress; Budapest, Hungary; August 2006

34. Rodrigues F., Andrade P., Oliveira L., Caldeira M., Perestrelo R., Marques J.C., Câmara J.S; Volatile composition of famous grouse whiskey using solid phase microextraction with a PDMS fibre; 3th European Congress on Food; Sofia, Bulgary; May 2006

35. S. Costa, C. Pereira, J.C. Marques; Integration of Safety, Quality and Effectiveness management systems in the construction industry; 3rd International Conference Working on safety; De Eemhof, The Netherlands, September 2006

36. Santos J.L., Pêgo A.P., Granja P.L., Tomás H.; In vitro evaluation of gene delivery in Bone Marrow Stromal Cells by Polyamidoamine Dendrimers; 14th Annual Congress of the European Society of Gene Therapy; Athens; 2006

37. Santos J.L., Pêgo A.P., Oliveira H., Granja P.L., Tomás H.; PAMAM dendrimers as gene delivery vectors for bone Tissue Engineering; 7th Advanced Course in Cell Material Interactions at Molecular Level; Porto; 2006

38. Santos J.L., Pêgo A.P., Oliveira H., Granja P.L., Tomás H.; Use of Polyamidoamine Dendrimers as Gene Delivery Vectors for Bone Tissue Engineering; 1st Marie Curie Cutting Edge InVENTS Conference on New Developments on Polymers for Tissue Engineering, Replacement and Regeneration; Funchal; 2006




39. Sedláková P., Svobodová J., Mikšík I., Tomás H.; Study of separation of PAMAM dendrimers by capillary electrophoresis; ITP 2006; 15th International Symposium on Capillary Electroseparation Techniques; Paris; 2006

40. Tomás H., Fernandes L.F., Calabretta A., Pereira J.A., Costa M.A., Fernandes M.H.; Osteoblastic differentiation over an adsorbed collagen layer, over the surface of collagen gels and inside collagen gels; 1st Annual International Meeting of the Portuguese Society for Stem Cells and Cellular Therapies; SPCE-TC; Funchal; 2006

41. Csók Z., Mesquita J.C, Rodrigues J., Nättinen K., Rissanen K.; Organometallic ZIGZAG Complexes with Mixed Metals as potential molecular wires; XXII International Conference on Organometallic Chemistry (ICOMC); 23rd - 28th of July, Zaragoza, Spain; 2006

SCIENCE DIVULGATION COMMUNICATIONS 1. Rodrigues J., “Nanomateriais – Uma viagem Maravilhosa; Escola Jaime Moniz”, Funchal, April,

2006

2. Tomás, H., “Um dia na vida do Zequinha”; in the scope of the set of colloquia “The incredible moments in Chemistry” organized by UTAD/Vila Real, Portugal, June, 2006



7. Funding

Since its creation in 2004, CQM had the support of FCT and received a budget proportional to the rating

obtained in the evaluation and to the number of Ph. D. in the research team (Pluri-annual Programme:

€ 43 200).

From 2004 untill the end of December 2006, the CQM was also involved in research projects (national

projects funded by FCT, AdI and other financial sources; international projects in the scope of the

program INTERREG IIIB; FCT grants) totalizing a value ca. of € 2.636.000 (a total amount that

considers the budget of all partners involved), besides its involvement in the two national networks of

NMR and MS (that correspond to a total budget of € 9.800.000). From these project amounts that

includes Pluri-annual Programme, about € 1.812.000 were directly managed by CQM members and

applied in their research activities.

From Figure 4, which shows the distribution of CQM financial resources by type, we can conclude that

the income managed by CQM equally came from European projects, national projects, FCT grants

(Ph.D. and Post-Doc grants) and the re-equipment projects (national networks of NMR and MS). Even if,

during the period 2004-2006, the support received through the Pluri-annual Programme only represents

2% of the total budget managed by CQM, this support, in addition to the human resources funds, was

undoubtedly fundamental for the normal running of the unit research activities.

€ 446.179; 25%

€ 43.200; 2%

€ 386.410; 21%

€ 478.353; 26%

€ 10.399; 1%

€ 447.440; 25%

RE-EQUIPMENT PROJECTS

FCT PLURI-ANNUAL (2004-2005)

NATIONAL PROJECTS (FCT, AdI)

EUROPEAN PROJECTS (INTERREG IIIB)

OTHER PROJECTS

HUMAN RESOURCES (FCT GRANTS)

Figure 4. Distribution of CQM funding by source, from 2004 till the end of 2006




8. Main supporters

The research unit receives financial support from:

Other supports:


http://www.gulbenkian.pt/main.asp




9. Annexes

2006: 2006: 2006: 23

COLABORAÇÕESCOLABORAÇÕES IVBAM, Madeira Wine Company, Jardim Botânico da Madeira;

INEB, Universidade do Porto, Universidade do Minho;

Center for Advanced Research in Biotechnology (EUA),

Instituto Canario de Investigación del Cáncer, Materials Res. Institute (Univ. de Sheffield Hallam, UK), NanoScience Center (Univ. de Jyvaskyla, Finlândia),

NEC – Corporation, Fundamental and Environmental Research Laboratories (Japan).

ARTIGOSARTIGOS

Centro de Química da MadeiraCentro de Química da MadeiraCentro de Química da Madeira 200620062006

Objectivos: Objectivos: Objectivos: Desenvolver a investigação científica na Universidade da Madeira na

área da Química e nas suas áreas afins.

Áreas de Investigação: Áreas de Investigação: Áreas de Investigação: Produtos Naturais Materiais

Membros e Colaboradores:Membros e Colaboradores:Membros e Colaboradores: Doutorados: 14

Estudantes de doutoramento: 6

Colaboradores: 6

Laboratórios de Investigação e Desenvolvimento: Laboratórios de Investigação e Desenvolvimento: Laboratórios de Investigação e Desenvolvimento: Laboratório de Biomateriais e Engenharia de Tecidos

Laboratório de Modelação Molecular

Laboratório de Química Analítica e Enologia

Laboratório de Química de Coordenação e Materiais Moleculares

Laboratório de Química Orgânica e Produtos Naturais

© 2006 Centro de Química da Madeira Universidade da Madeira

http://cqm.uma.pt

SPONSORSSPONSORS

MMEEMMEENNTTOO Jan Mar 06

Newsletter editada pelo Centro de Química da Madeira / Departamento de Química da Universidade da Madeira – Contacto: [email protected]

© 2006 Centro de Química da Madeira / Departamento de Química / Universidade da Madeira

http://cqm.uma.pt

Reunião Linha Materiais No passado dia 27 de Janeiro realizou-se no Hotel Crowne, a reunião anual da Linha de Materiais do CQM. Para além da apresentação pública do relatório de actividades, referente aos anos de 2004-2005, foram apresentadas 8 comunicações orais sobre os trabalhos em curso no CQM. Este encontro que contou com a participação da maioria dos membros do CQM, serviu igualmente para discutir as conclusões do relatório de actividades e concertar as estratégias de colaboração entre os membros do Centro. CQM – Divulgação Na sequência dos artigos realizados pela Revista do DN-Madeira sobre a investigação realizada na Universidade da Madeira, e que já abrangeu os membros do CQM, Helena Caldeira, José Câmara e Helena Tomás, foi publicado em 29 de Janeiro na mesma revista um artigo com o título: Na rede nacional de investigação. No artigo procurou-se dar-se destaque aos projectos em curso no CQM e à integração da unidade nas redes nacionais de NMR e de EM. Estão previstos outros artigos envolvendo outros investigadores do CQM. Visita de estudo a Lisboa 25 alunos do curso de pós-graduação em Segurança e Higiene do Trabalho, promovido pelo CQM, tiveram a oportunidade de alargar os seus conhecimentos com uma visita de estudo realizada a diversas empresas da área de Lisboa no passado dia 3 de Fevereiro. Foram visitadas as empresas A Silva e Silva, Medilabor, 3M e ainda a Bruel e Kjaer para uma formação extra na área de medição de ruído ocupacional. A visita foi considerada muito proveitosa pelos formandos que na Madeira têm poucas oportunidades de conhecer outros ambientes industriais. ________________________________________ Projecto Antivinmac – reunião em Canárias Decorreu no passado dia 17 de Fevereiro a primeira reunião de apresentação do Projecto Antivinmac, liderado por J. Câmara do CQM. A Reunião teve lugar na Universidade de La Laguna e envolveu as equipas dos 3 parceiros do projecto (Madeira, Canárias e Açores). Houve ainda oportunidade de visitar uma das mais importantes adegas de Tenerife. ________________________________________ Alunos Noruegueses em visita ao CQM No passado dia 23 de Fevereiro de 2006 visitaram o Centro de Química da Madeira um grupo de 30 alunos provenientes de Stavanger (Noruega) em visita de estudo à Madeira. Para

além da visita aos laboratórios pelos visitantes, foi feita ainda uma palestra sobre a História e a Química do Vinho Madeira, apresentada por J.C. Marques. ________________________________________ Eleições CQM No passado dia 8 de Março realizaram-se as eleições para coordenador científico do CQM, tendo sido eleito J.C.Marques por maioria dos votos expressos. De acordo com o regulamento da unidade, a eleição é realizada de dois em dois anos. V Wine World Fórum O CQM participou no V Wine World Fórum realizado em Logroño (Espanha) nos passados dias 27 a 30 de Março. Nesse encontro em que também participaram dois elementos ligados ao Instituto do Vinho da Madeira, foram apresentados os trabalhos realizados na Adega de S. Vicente no âmbito do projecto CARVINMAC. ________________________________________ Comunicações e papers publicados “cis-[Bis(diphenylphosphino)ethane-k2P,P'] dichlororuthenium(II) dichloromethane disolvate", Luca Russo, João Figueira, João Rodrigues and Kari Rissanen, Acta Cryst., 2006, E62, m1154-m1155. “From Simple Monopyridine Clusters [Mo6Br13(Py-R)6][n-Bu4N] and Hexapyridine Clusters [Mo6X8(Py-R)6][OSO2CF3]4 (X = Br or I) to Cluster-cored Organometallic Stars, Dendrons and Dendrimers”, Denise Méry, Lauriane Plault, Cátia Ornelas, Jaime Ruiz, Sylvain Nlate, Didier Astruc, Jean-Claude Blais, João Rodrigues, Stéphane Cordier, Kaplan Kirakci, and Christiane Perrin, Inorganic Chemistry, 2006, 45,1156-1167. "Ruthenium Metallodendrimers Based on Nitrile-Functionalized Poly(alkylidene imine)s", Catia Ornelas, Viatcheslav Vertlib, João Rodrigues, Kari Rissanen, Eur. J. Inorg. Chem., 2006, 1, 47-50. "1-cis,cis,cis-Aquabis[bis (diphenylphosphino) ethane-k2P,P´]chlororuthenium(II) hexafluorophosphate dichlomethane 1.5,water 0.5-solvate", Luca Russo, João Figueira, João Rodrigues and Kari Rissanen, Acta Cryst., 2006, E62, m699-m701.

Comunicações orais: "Organometallic Materials for Photonics and Molecular Electronics Nanoscale Devices", João Rodrigues, Zsolt Csok, Wojciech Czardybon, João Figueira, Manuel Jardim, José Mesquita, M. Helena Garcia, M. Paula Robalo, Wim Wenseleers and Kari Rissanen, “Synthesis and Structural Characterization of a New Family of Ruthenium Metallodendrimers With Potential Nonlinear Optical Applications”, Zsolt Csok, Manuel Jardim, José Carlos Mesquita, João Rodrigues, Wim Wenseleers, Jochen Campo and Kari Rissanen, Annual Meeting of CQM/Materials Team, Funchal, Portugal, 27 January, 2006. “Synthesis and Characterization of a Novel Family of Pt (II) and Pd(II) Metallomolecular Wires”, Wojciech Czardybon, João Rodrigues, Luca Russo, and Kari Rissanen, Annual Meeting of CQM/Materials Team, Funchal, Portugal, 27 January, 2006. “Preparation of Ruthenium Molecular Wires Using 1,4-Diethynylbenzene Derivatives as Spacer Ligands”, João Figueira, João Rodrigues, Luca Russo, and Kari Rissanen, Annual Meeting of CQM/Materials Team, Funchal, Portugal, 27 January, 2006. “Stepwise Construction of a Molecular Wire at Gold Surfaces Using an Acetylide Ruthenium Complex as Building Block”, Manuel Jardim, João Rodrigues, Cátia Ornelas, Jaime Ruiz, and Didier Astruc, Annual Meeting of CQM/Materials Team, Funchal, Portugal, 27 of January, 2006.

MMEEMMEENNTTOO Abr Jun 06

Newsletter editada pelo Centro de Química da Madeira / Departamento de Química da Universidade da Madeira – Contacto: [email protected]

© 2006 Centro de Química da Madeira / Departamento de Química / Universidade da Madeira

http://cqm.uma.pt

Programa SÓCRATES/ERASMUS O Prof. João Rodrigues esteve, de 8-14 de Abril, ao abrigo do Programa SOCRATES/ERASMUS no NanoScience Center – Universidade de Jyväskylä, Finlândia. De 5 a 11 de Junho visitou a Universidade de Bordéus I (Nanosciences and Catalysis Group) ao abrigo do Programa Bilateral Pessoa, para discutir o trabalho de investigação em curso e para apresentar um seminário convidado no Centre de Physique Moléculaire Optique et Hertzienne da mesma Universidade. De 2 a 8 de Julho deslocou-se a Boulder nos Estados Unidos para apresentar uma Comunicação Oral convidada na Fourtheen International Conference on Composites/Nano Engineering (ICCE-14). Além de integrar o Comité Científico desta conferência anual que reúne, anualmente, mais de 400 investigadores que trabalham nas áreas da investigação e desenvolvimento dos Materiais e da Engenharia, foi igualmente co-chairman de uma das sessões sobre nanomateriais (Nano 1).

Seminário Segurança no Trabalho José C. Marques do CQM foi convidado a participar na sessão comemorativa do Dia Mundial para a Segurança e a Saúde no Trabalho realizada no dia 28 de Abril no Instituto Regional de Emprego da Madeira. Na sessão foi apresentada uma comunicação sobre a participação da Universidade da Madeira no desenvolvimento e promoção da Segurança, Higiene e Saúde no Trabalho na Região Autónoma da Madeira. ________________________________________ Projecto IMPACT No âmbito do projecto IMPACT, projecto financiado pela Agência de Inovação e que envolve o CQM, a Escola Superior de Biotecnologia e a Madeira Wine Company, realizaram-se nos passados dias 19, 21, 27 e 28 de Abril, 31 de Maio e 1 e 2 de Junho diversas provas organolépticas de modo a seleccionar o melhor vinho estufado na escala piloto instalada na Universidade da Madeira.

CEfood2006 Dois elementos do CQM participaram na Conferencia CEfood 2006, realizada em Sofia (Bulgária) de 22 a 25 de Maio de 2006 onde foram apresentados diversos trabalhos realizados no Centro. O CEfood está especialmente vocacionado para o estabelecimento de parcerias tendo em vista os projectos do 7PQ. ________________________________________

1º Encontro Anual Internacional da Sociedade Portuguesa de Células Estaminais e Terapia Celular (SPCE-TC) Decorreu, dias 30 e 31 de Maio, no Hotel Crowne Plaza Resort (Funchal), o 1º Encontro Anual Internacional da SPCE-TC, numa organização conjunta das Universidades do Madeira (através do CQM) e do Minho (através do 3B’s Research Group). O CQM marcou a sua presença neste encontro, também, com a apresentação de 2 comunicações em painel e uma keynote lecture.

Marie Curie Conference - New developments on polymers for tissue engineering, replacement and regeneration O CQM participou na organização local da conferência “New developments on polymers for tissue engineering, replacement and regeneration” que reuniu, entre 1 e 5 de Junho, no Hotel Crowne Plaza Resort (Funchal), para além de estudantes de doutoramento e pós-doutoramento, mais de uma dezena de especialistas de topo a trabalhar na área de Engª de Tecidos Humanos. Esta conferência foi a primeira, de um conjunto de 6 conferências de alto nível apoiadas pela Comunidade Europeia, no âmbito do programa “Marie Curie Conferences & Training Courses” (projecto “InVents”, coordenado pelo Prof. Rui Reis da Universidade do Minho). A participação do CQM nesta conferência envolveu, ainda, a apresentação de 1 comunicação em painel e de uma keynote lecture - “Tissue Engineering Research in Madeira – a Gene Delivery approach”.

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Ciclo de colóquios – “Os incríveis momentos em Química” A Prof. Helena Tomás participou, dia 7 de Junho de 2006, como oradora, no ciclo de colóquios “Os incríveis momentos em Química” organizado pela UTAD – “Um dia na vida do Zéquinha” foi o título da lição dirigida para os estudantes de 9ºano do ensino secundário.

XXIX OIV congress 2006 Dois elementos do CQM participaram no XXIX congresso da OIV (Organisation Internationale de la Vigne et du Vin) que se realizou em Logroño (Espanha) de 25 a 28 de Junho de 2006, onde foram apresentados vários trabalhos resultantes dos projectos em curso no Centro. O Congresso da OIV é o maior encontro mundial realizado nesta área. ________________________________________ Exames finais da PG - HST Decorrem de 28 de Junho a 1 de Julho as apresentações e defesas dos trabalhos finais realizados pelos 28 alunos da Pós-graduação em Segurança e Higiene do Trabalho, promovida pelo CQM. Os trabalhos realizados envolvem vários aspectos ligados à segurança nas empresas da região. A cada exame está reservada uma hora para apresentação e discussão perante um júri de três elementos. Para o efeito, deslocam-se de Lisboa o Dr. JM Monteiro, e os Eng. Rocha Martins e Henrique Guisado, ligados ao curso do ISCTE. Foi ainda feito o convite para a participação de um elemento da Direcção Regional do Trabalho, entidade que homologou o curso. ________________________________________ Comunicações orais: “From Metallodendrimers for NLO to Molecular Wires for Nanoelectronic Applications” João Rodrigues, Centre de Physique Moléculaire Optique et Hertzienne,University of Bordeaux 1, France, 9 of June, 2006. (Seminário convidado)

A QUÍMICA É DIVERTIDAhttp://www.uma.pt/quimicadivertida

PROGRAMA

16hCOLÓQUIO

eEntrega de Prémios

do CONCURSO“A experiência mais

divertida”Madeira Magic

16hCOLÓQUIO

Madeira Magic

10hCONCURSO

“A experiência mais divertida”

Madeira Magic

14-17hSessões

experimentais de Química e

Bioquímica

Visitas guiadas aos laboratórios do CQM

3º ciclo do ensino básico e ensino

secundárioUniv. Madeira

14-17hSessões


Bioquímica


1º e 2º ciclos do ensino básicoUniv. Madeira

14-17hSessões


Bioquímica


Jardim de InfânciaUniv. Madeira

SEXTA24/11

QUINTA23/11

QUARTA22/11

TERÇA21/11

SEGUNDA20/11

ORGANIZAÇÃO APOIOS

“QUÍMICA REGENERATIVA”Pedro L. GranjaINEB – Instituto de Engenharia Biomédica, Universidade do Porto23 NOVEMBRO, 16hLocal: Madeira Magic

“BIOQUÍMICA, ANTIBIÓTICOS E ALTERNATIVAS ANTIMICROBIANAS DO SÉC. XXI”Maria do Céu CostaINFARMED / INETI - Instituto Nacional de Engenharia e Tecnologia Industrial 24 NOVEMBRO, 16hLocal: Madeira Magic

Centro de Química da MadeiraDepartamento de Química

Universidade da MadeiraCampus da Penteada

9000-390 FunchalTelef.: 291 705100

Fax: 291 [email protected]

com a colaboração doCENTRODE QUÍMICADA MADEIRA

Documents

Activity Report 2006 - UMa · 9000-081 Funchal NIF: 680041982 Research Lines Natural Products Materials Keywords Enology Phitochemistry Materials Biomaterials . Centro de Química