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JANIA RUBENS
Jania comes from the Latin Janus, the two-headed god of Roman
mythology, guardian of the House of the Gods. Rubens means the
colour red. The alga was given this name due to its dichotomous
branching and its colour. Jania Rubens is a calcified alga that grows
from 15 to 40 mm in height. It is fairly rare and represents a sort of
tree of life where, thanks to its calcified structure, a wide range of
microscopic species finds a protection.
To prevent removal of this rare resource from its natural habitat, our
laboratory has been the first one to develop cultures in a
photobioreactor with controlled temperature, light and culture
media. The algae obtained using this method have the shape of a
pompom, similar to that observed in their natural habitat, but
without any epiphytes. The extract obtained from it: Actiporine 8G is
guaranteed to be 100% natural and to have no traces of impurities.
In heart cells, mitochondria plays a central role in their vitality and activity. In fibroblasts, a mitochondrial
dysfunction results in a decrease in collagen synthesis and acceleration of skin ageing process. ACTIPORINE 8G
provides a unique mechanism of mitochondrial detoxification to boost collagen synthesis and to reduce the
appearance of wrinkles.
TECHNOLOGICAL INNOVATION: THE CULTIVATION OF JANIA RUBENS
A UNIQUE ACTION MECHANISM
ROLE OF MITOCHONDRIA IN COLLAGEN SYNTHESIS
Collagen synthesis is connected to the integrity, vitality and thus
energy reserves of the fibroblasts. However the only source of energy
available to the cells is ATP, which is synthesised by the mitochondria.
IMPORTANCE OF MITOCHONDRIAL DETOXIFICATION
It is now well known that mitochondrial DNA, due to its closeness to
reactive oxygen species, and mainly H2O2, is continually subject to
damages and mutations leading to mitochondrial malfunction and loss
of cellular vitality.
However H2O2 is a messenger of vital importance in a large number of
metabolic reactions. Therefore it is important to remove H2O2 from
the mitochondria without, however, completely eliminating it.
THE ROLE OF AQUAPORIN 8 IN MITOCHONDRIAL DETOXIFICATION
It has been shown that Aquaporin 8 (AQP8), membrane channel
already known for its role in the transport of urea, is also capable to
ensure the passage of H2O2 through the mitochondrial membrane.
THE ANTI-AGEING STRATEGY DEVELOPED BY ACTIPORINE 8G IS BASED
ON AN INCREASE IN THE NUMBER OF AQP8 TO PROMOTE H2O2
EVACUATION, MITOCHONDRIAL DETOXIFICATION AND THEREFORE
THE ACTIVATION OF COLLAGEN SYNTHESIS BY FIBROBLASTS.
Aquaporin
IN-VITRO TESTS
IN-VIVO TESTS
Protocol : Normal human dermal fibroblasts (37 years old women)
treated with 0.2% Actiporine 8 G for 24 hours.
ACTIPORINE 8G INCREASES AQP8 SYNTHESIS BY +58%*.*p<0.05 Student test,
ACTIPORINE 8G ACHIEVES 100% MITOCHONDRIAL DETOX
The basal rate measurement of H2O2 in the mitochondria showed a 17%
accumulation of H2O2 under conditions of cellular stress (induced
release of H2O2). Under these conditions, only Actiporine 8G is capable
of removing 100% of accumulated H2O2. Recycling H2O2 outside the
mitochondria is a strategy which is more efficient than the use of a
powerful anti-oxidant such as Vitamin E.
ACTIPORINE 8G REACTIVATES COLLAGEN SYNTHESIS+24% de collagen I
+28% de collagen IV
+51% de collagen 7
Visualization (in red) of H2O2
accumulation inside the
mitochondria of untreated
fibroblasts [A], fibroblasts
treated with H2O2 inducer
[B], and fibroblasts treated
with H2O2 inducer +
Actiporine 8G [C]
A
CB
ACTIPORINE 8G INCREASES COLLAGEN DENSITY IN DERMISProtocol : 20 volunteers. Application of a cream containing 2% Actiporine 8 G
on the thighs, twice daily for 4 and 8 weeks. Analysis of collagen synthesis in
dermis by echography
AFTER 28 DAYS: +5% COLLAGEN DENSITY AND UP TO +61%
AFTER 56 DAYS: +15%* COLLAGEN DENSITY AND UP TO + 54%
*p<0.05 Student test
ACTIPORINE 8G DECREASES CROW’S FEET WRINKLES IN 14 DAYSProtocol: 20 volunteers. Application of a cream containing 2% Actiporine 8G
or a placebo, on crow’s feet wrinkles twice daily for 2 weeks.
ROUGHNESS: -5,1%* AND UP TO -44%
WRINKLE VOLUME: -11,5% AND UP TO -85%
WRINKLE AREA: -9,4% AND UP TO -57%
*p<0.05 Student test
H2O2 RECYCLING THANKS TO AQP8 ALLOWS A COMPLETE
DETOXIFICATION OF MITOCHONDRIA AND A REACTIVATION OF
COLLAGEN SYNTHESIS FOR VISIBLE RESULTS ON CROW’S FEET
WRINKLES AFTER ONLY 2 WEEKS.
Visualization in green of
collagen density in the dermis,
before treatment [A], after 4
weeks treatment [B] and after
8 weeks treatment [C]
A
CB
ACTIPORINE 8G – ANTI-AGEING & MITOCHONDRIAL DETOXIFICATION
COSMETIC ACTIVITIES
• Activates the synthesis of mitochondrial AQP8 in fibroblasts
• Detoxifies mitochondria of fibroblasts
• Increases the synthesis of collagen I, IV and VII
• Improves collagen density in dermis
• Decreases skin roughness
• Decreases volume and surface of wrinkles within 2 weeks
INCI NAME
Glycerin (and) Water (and) Jania Rubens extract - !OK CHINA!
RECOMMENDED % OF USE: 2%
Technical department : [email protected]
Commercial department : [email protected]
70, rue du Commandant l’Herminier – CS11781 - 35417 Saint-Malo cedex - FRANCE
Tel : +33-2-23-18-31-07 Fax : +33-2-23-18-31-01
www.codif-recherche-et-nature.com