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R E L E A S E N O T E S
ACQUITY, ACQUITY UPLC, Connections INSIGHT, nanoACQUITY UPLC, Synapt, Waters, and Xevo are registered trademarks and Auto•Blend, eCord, Empower, LAC/E32, MassLynx, Q-Tof, and “THE SCIENCE OF WHAT’S POSSIBLE.”
are trademarks of Waters Corporation. All other trademarks are the sole property of their respective owners.
Copyright 2011 - 2012 Waters Corporation
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*716003340* *Rev.B*
ACQUITY UPLC Systems June 2011 Driver Pack and Firmware Updates
What’s new in this release ......................................................................................................... 3
Reasons for installing this software release ............................................................................... 3
Installation Notes ....................................................................................................................... 3
Recommended firmware ............................................................................................................. 4
New Features and enhancements ............................................................................................... 4
ACQUITY UPLC Console ............................................................................................................... 4
Column Managers ...................................................................................................................... 4
Solvent Managers ...................................................................................................................... 5
Leak testing ........................................................................................................................... 5
Pressure limits........................................................................................................................ 5
Miscellaneous changes ............................................................................................................ 5
Sample Managers ....................................................................................................................... 6
Detectors .................................................................................................................................. 6
Photodiode Array (PDA) Detector .............................................................................................. 6
Optics temperature stabilization feature .................................................................................... 7
Enhancement to the lamp and flow-cell resident memory ............................................................ 7
Failing result on the wavelength verification test ......................................................................... 7
Re-creating the method ........................................................................................................... 7
Sample Organizer ...................................................................................................................... 7
Ensuring the correct configuring of vial caps and shelf locations .................................................... 8
Analyst Software ........................................................................................................................ 8
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MassLynx software ..................................................................................................................... 8
Empower 3 software ................................................................................................................... 8
Clinical/IVD ACQUITY UPLC Systems............................................................................................. 8
Connections INSIGHT ................................................................................................................. 9
Waters Pump Control for MassLynx software ................................................................................. 9
Waters Columns Calculator .......................................................................................................... 9
Contents of ACQUITY UPLC Systems June 2011 Driver Pack DVD ............................................... 9
Hardware and Software Requirements ..................................................................................... 14
Supported Waters hardware: ...................................................................................................... 14
Supported Waters and third-party software .................................................................................. 14
Backward Compatibility.............................................................................................................. 15
Supported operating systems ..................................................................................................... 15
ACQUITY UPLC minimum hardware requirements and maximum detector data rates ......................... 16
Installing the ACQUITY UPLC Systems June 2011 Driver Pack Release .................................... 16
Installation method ................................................................................................................... 17
Using the repair function ............................................................................................................ 18
Installing the Updated Firmware Release ................................................................................. 18
Installing this Release in an Empower Enterprise Environment ................................................ 19
Installing Empower ICS on a Citrix server ................................................................................ 20
Troubleshooting and Uninstalling ............................................................................................. 20
ICS Companion ......................................................................................................................... 21
Overview ................................................................................................................................. 21
Technical information ................................................................................................................ 22
Installation validation ................................................................................................................ 22
Workaround ............................................................................................................................. 22
Disabling the service ................................................................................................................. 22
Restoring an SQ and TQ Empower 2 project for use with IntelliStart ....................................... 23
Defects addressed by this release ............................................................................................ 24
Known defects in this release ................................................................................................... 26
ACQUITY UPLC System Qualification ........................................................................................ 27
Requalification Guidelines .......................................................................................................... 27
Contacting the Waters Technical Service Organization ............................................................. 27
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What’s new in this release The following items are new to revision B of the ACQUITY UPLC June 2011 Driver Pack:
• Revised release notes
• Additional firmware updates for the ACQUITY UPLC sample managers, the ACQUITY UPLC Sample Organizer, and the ACQUITY UPLC Column Manager with Active Preheater.
See also:
• ACQUITY UPLC Sample Managers Firmware Version 1.51 Release Notes
• Waters ACQUITY UPLC Systems June 2011 Driver Pack Addendum Release Notes
Reasons for installing this software release You must install this software release to perform the following tasks:
• Operate ACQUITY UPLC®
• Operate an ACQUITY UPLC System with 2D Technology. (For details, refer to the ACQUITY UPLC Systems with 2D Technology Release Notes.)
I-Class systems (all configurations).
• To benefit from improvements to the Waters Column Calculator.
• To enable remedies and enhancements for existing products (such as ACQUITY UPLC H-Class Systems).
Important: Revision B of the ACQUITY UPLC June 2011 Driver Pack media includes both the firmware from the original release of the June 2011 driver pack and additional firmware updates specific to revision B. The additional firmware updates, specific to revision B, are available separately on the media and must be installed manually after you complete the installation of the driver pack.
16For details, refer to the
installation instructions on page . See page 4 to determine whether or not a firmware upgrade is required for your system.
Note: The ACQUITY UPLC 2011 Driver Pack is only compatible with firmware installed by the driver pack. Follow the driver pack instllation instructions on 16page to ensure that the correct firmware is installed on your instruments.
A list of problems addressed in this release appears later in this document.
See also: Your system’s user documentation CD for information about system modules.
Installation Notes On an Empower Enterprise (client/server) system, install the driver/firmware according to the instructions on page 16. You must do so on all clients, LAC/E32™ modules, and Citrix application servers in the system. You need not, however, install the driver/firmware on the database server unless the server’s client software interacts with an instrument or device.
Customers with Empower Enterprise systems who use both ACQUITY UPLC and ACQUITY UPLC H-Class systems must update all ACQUITY instrument control software (ICS) implementations in their environment to the June 2011 Driver Pack. The ACQUITY UPLC Systems June 2011 Driver Pack does not support mixed use of ACQUITY UPLC ICS versions.
Important: Revision B of the ACQUITY UPLC June 2011 Driver Pack media includes both the firmware from the original release of the June 2011 driver pack and additional firmware updates specific to revision
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B. The additional firmware updates, specific to revision B, are available separately on the media and must be installed manually after you complete the installation of the driver pack. For details, refer to the installation instructions on page 16.
Recommended firmware
See page 4 to determine whether or not a firmware upgrade is required for your system.
Waters recommends installing the ACQUITY UPLC Sample Managers Firmware, version 1.51. The firmware is available separately on this media, or may already be installed on new systems.
Users should upgrade the firmware for their sample manager or sample organizer to version 1.51 in the following systems:
• ACQUITY UPLC, ACQUITY UPLC H-Class, or ACQUITY UPLC I-Class systems that run the ACQUITY UPLC Systems June 2011 Driver Pack and ACQUITY UPLC Sample Managers firmware, version 1.50.
• ACQUITY UPLC systems that include a sample organizer that displays the error message "Transfer Shuttle homing error".
• Do not install the ACQUITY UPLC Sample Managers firmware, version 1.51 upgrade on any ACQUITY UPLC, ACQUITY UPLC H-Class, or ACQUITY UPLC I-Class systems supported by a driver pack version earlier than the ACQUITY UPLC Systems June 2011 Driver Pack.
Notes:
• The ACQUITY UPLC Sample Manager driver is the same for both the ACQUITY UPLC Sample Manager and the ACQUITY UPLC Sample Manager–FL.
Waters recommends installing the ACQUITY UPLC Column Manager with Active Preheater Firmware, version 1.51. The firmware is available separately on this disk. For some new systems, it is already installed.
New Features and enhancements This section details new features and enhancements to the ACQUITY UPLC systems and components.
ACQUITY UPLC Console The ACQUITY UPLC Console’s About box now includes build dates.
Column Managers In MassLynx™ software, column managers are now configured as detectors. The column manager firmware installed by the ACQUITY UPLC Systems June 2011 Driver Pack installer is version 1.50. Nevertheless, a newer version of the firmware, version 1.51, is included on the June 2011 Driver Pack media. After installing the June 2011 Driver Pack, you must manually install the version 1.51 column manager firmware. For details, refer to the installation instructions on page 16.
Requirement:
New, advanced-mode features of the column manager with active preheater (CM-A) include the ability to directly control two, internal, 6-port, 2-position valves in the CM-A through the inlet method editor.
In the case of ACQUITY UPLC systems that include column managers, you must re-create preexisting MassLynx methods.
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Use advanced mode features only with the CM-A. Do not use them with older column managers (CM).
You can use as many as three external valves with the CM-A.
External valve Part number
10-port, 2-position, Titanium 417000138
7-port, 6-position, PEEK™ 417000139
11-port, 10-position, stainless steel 417000150
Solvent Managers
Leak testing
The static leak test is no longer available. Instead, the binary solvent manager offers a dynamic leak test, which you can perform on an individual pump or system. The test can compresses fluids to the test pressure condition. It can accommodate both highly compressible fluids and the additional fluid volume compressed during a system test. You can specify a short time interval, to prime system components, before running the dynamic leak test. The criterion for passing an individual pump test is a leak rate of less than 200 nL/min. For a passing system test, it is a leak rate of less than 600 nL/min.
Note:
Pressure limits
It is possible to pass the new dynamic leak test with a negative result. In some instances, the accumulator check valve can leak back into the primary actuator at a very low rate, causing a negative result. The test parameters allow negative results to -50 nL/min.
In ACQUITY UPLC I-Class systems, the maximum pressure limit you can specify in the method editor is 18,000 psi. If your system includes a pump that cannot accommodate that pressure, an error message stating so appears on-screen when the maximum pressure limit is reached.
In ACQUITY UPLC H-Class systems, however, the maximum pressure limit that you can specify in the method editor is 15,000 psi.
The maximum pressure limit of a method persists after it runs. To change the limit, you must load a new method that specifies a different maximum pressure limit.
Miscellaneous changes
This update to the ACQUITY UPLC Systems June 2011 Driver Pack includes these additional changes:
• You can now access the Waters Columns Calculator from the method editor.
• The binary solvent manager now offers a Gradient Start feature, similar to that of the quaternary solvent manager. Use this feature to start the gradient function before an injection, for a specified period. You can also delay the start of the gradient after the injection, for a specified period.
• The method editor now graphically displays gradient conditions.
• You can now graphically display gradient conditions when you select Auto•Blend™ mode for the ACQUITY UPLC Quaternary Solvent Manager.
• You can expand the gradient table so that it displays additional rows.
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Sample Managers The sample manager firmware released as part of the ACQUITY UPLC Systems June 2011 Driver Pack is version 1.50. Nevertheless, a newer version of the firmware, version 1.51, is included on the June 2011 Driver Pack media. After installing the June 2011 Driver Pack, you must manually install the version 1.51 sample manager firmware. For details, refer to the installation instructions on page 16.
These are the sample manager changes associated with the ACQUITY UPLC Systems June 2011 Driver Pack:
• For the sample manager and sample manager-FL, to help reduce persistent carryover, you can now select a timed event, “Cycle inject valve”. Cycling the injection valve for one or more cycles (at the end of a gradient run, for example) can help reduce carryover.
Caution: To avoid reducing valve life, necessitating relatively frequent valve replacements, do not cycle the valve more than is necessary to minimize carryover.
• For the sample manager, sample manager-FTN, and sample manager-FL, to prevent carryover resulting from contact of the puncture needle with sample in plates whose wells are shallow, the pierce depth of the puncture needle is now 5 mm on all plates less than 15 mm high.
Note, however, that pierce depth of all 384-well plates is 5 mm, regardless of plate height.
• For the sample manager and sample manager-FL, you now specify options in the Advanced window.
• For the sample manager, sample manager-FTN, and sample manager-FL, a “No Injection” option is now available in the Advanced section of the Method editor.
• For the sample manager and sample manager-FL, when using Empower™ 3 software, the injection volume is now limited to the available sample loop volume.
• For the sample manager-FTN, in Empower 3 software, the injection volume is now limited to the extension loop volume when the configured loop volume is greater than zero. Otherwise, the maximum injection volume equals the configured needle volume less 5 µL.
• For the sample manager, sample manager-FTN, and sample manager-FL, an R-calibration procedure is available to ensure correct needle and vial (or well) positioning. This calibration is necessary only when using 384-well plates.
• The sample manager-FTN Console plots are updated to include the Inject Mark feature.
Detectors
Photodiode Array (PDA) Detector
• For the photodiode array (PDA) detector, on the general tab of the instrument method editor, you can now specify a negative absorbance margin to accommodate increases in optical transmission during a gradient run (HILIC chromatography, for example). The default value is -0.07 AU.
You typically need a greater negative absorbance margin when the absorbance baseline saturates or exhibits a flat, noiseless trace within the chromatogram. Note, however, that a greater negative absorbance margin can decrease the positive end of the linear dynamic range.
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Optics temperature stabilization feature
For thermally enhanced detectors—the photodiode array (PDA), eλ PDA, and tunable UV (TUV)—an optics temperature stabilization feature helps reduce the sensitivity of the absorbance signal to environmental fluctuations (temperature and humidity, for example). This feature is available only for thermally enhanced detectors. This table specifies settings and instrument environments.
Setting Instrument environment
Normal temperature (default) Suitable for most air-conditioned environments.
Elevated temperature Recommended for environments where the sustained average temperature exceeds 30 °C. (These are typically environments that are not air conditioned.)
Maximum cooling Recommended for any environment where the lowest possible temperature for the flowcell or lamp is desired. Optimum baseline stability is typically not achieved on this setting.
You can access this feature by clicking Configure > Preferences > Optics Temperature Stabilization.
Enhancement to the lamp and flow-cell resident memory
• For thermally enhanced detectors—the photodiode array (PDA), eλ PDA, and tunable UV (TUV)—an enhancement to the lamp and flow-cell resident memory automatically includes, at your option, lamp history and flow-cell characteristics in comprehensive status reports. The feature thus associates chromatographic results with the condition of the lamp and the type of flow cell you used. By default, this feature is inactive. You can activate it by clicking Configure > Preferences > Component Identification Requirement.
Failing result on the wavelength verification test
• For the PDA detector, if the wavelength verification test indicates a failing result during initialization, an error (previously a warning) occurs. To correct the error, establish flow through the instrument and cycle power to the detector. If the error persists, run the erbium calibration diagnostic.
Re-creating the method
• For the PDA detector, when you create a method, the analog output capabilities of the instrument included in the system are associated with the method (two analog outputs, for example). To accurately reflect the analog output capabilities of a different PDA detector (one analog output, for example), you must re-create the method when that instrument is connected to the system.
Sample Organizer The sample organizer firmware released as part of the ACQUITY UPLC Systems June 2011 Driver Pack installer is version 1.50. Nevertheless, a newer version of the firmware, version 1.51, is included on the June 2011 Driver Pack media. After installing the June 2011 Driver Pack, you must manually install the version 1.51 sample organizer firmware. For details, refer to the installation instructions on page 16.
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The following options are available for sample organizers compatible with sample managers fitted with a rotary tray:
Option Description
Plate Transfer (From the Troubleshoot menu)
Transfers all plates into and out of the sample manager a specified number of times.
Plate Sensor On/Off (From the Troubleshoot menu)
Turns the plate sensors on or off.
Disable Motors (From the Control menu) Disables the z axis motor for maintenance operations.
Interactive Display Allows direct control of sample organizer features.
Ensuring the correct configuring of vial caps and shelf locations
For sample organizers used with sample managers without a rotary tray, you can now select a “Disable shelf check” option from the Configure menu. When you do so, the option prevents the sample organizer from configuring vial caps as shelves and also the subsequent change warning resulting from the incorrect configuration. Shelf locations are correctly configured during the “Scan and store shelf layout” procedure and remain unchanged during a Reset or Verify command.
Requirement:
Analyst Software
You must remove reflective caps before using the “Scan and store shelf layout” command.
With Analyst Software, use only the Horizontal Discontinuous mode to configure the order of injections.
MassLynx software This table shows software change notes (SCN) and the model of mass spectrometer they support in this release:
SCN Mass spectrometer supported
733 quadrupoles SQD and TQD
781 Synapt®
802
G2 series
Xevo®
805
G2 Q-Tof™/Tof
quadrupoles SQD and TQD
810 Xevo TQ and TQ-S
855 Xevo TQD and SQD2
Empower 3 software • The Sys Startup function replaces the Sys Prep function.
Clinical/IVD ACQUITY UPLC Systems • This driver pack release should not be used for ACQUITY UPLC IVD marked systems.
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Connections INSIGHT These changes apply:
• Connections INSIGHT®
• You can now disable instrument status monitoring within Connections INSIGHT for a specific time period.
, included with this driver pack, is installed by default.
• Additional diagnostic information is now uploaded to Connections INSIGHT during an iHelp request.
• Connections INSIGHT is now fully supported on client server networks.
Waters Pump Control for MassLynx software • This driver pack release includes Waters®
Waters Columns Calculator
Pump Control. Pump Control now supports using as many as three model 515 pumps (P/N WAT207000) to accommodate ACQUITY UPLC Systems with 2D Technology.
These changes apply:
• The calculator now supports using 75-mm columns.
• When you launch the calculator from a method editor window, you cannot change your unit preferences from the calculator’s menu. The calculator uses the same unit preferences as those displayed in the Console software.
• When you launch the calculator independently (that is, not from a method editor window), and the Console software is also running, you can select unit preferences in either software application. When you change an aspect of one software application, the other reflects the change.
Tip:
• The calculator now correctly formats data for printing.
You must click the software window to see the preference update.
• The calculator now displays, in the main window, the column volumes for both the input and output columns.
• The calculator can now resolve time entries in the gradient table to 0.001 minutes.
Example: The software can distinguish between 2.27 and 2.28 minutes.
• Commands of “Copy” and “Paste” between the QSM or BSM method editors and the calculator window now function correctly.
• The calculator’s high-pressure limit is now 20,000 psi.
Contents of ACQUITY UPLC Systems June 2011 Driver Pack DVD
Recommendation: 3
Install this driver pack update on all ACQUITY UPLC Systems, to ensure features and capabilities are current. See “Reasons for installing this software release” on page .
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Requirement:
The DVD includes these items:
Customers with Empower Enterprise systems who have both ACQUITY UPLC H-Class and ACQUITY UPLC systems must update all ACQUITY Instrument Control Software (ICS) implementations in their environment to the June 2011 Driver Pack. Mixing of ACQUITY UPLC ICS versions is not supported with the ACQUITY UPLC Systems June 2011 Driver Pack.
• All current instrument drivers for ACQUITY UPLC I-Class System, ACQUITY UPLC H-Class, ACQUITY UPLC H-Class Bio, and ACQUITY UPLC instrument modules and detectors.
See also:
•
Your system’s user documentation CD for information on instrument modules.
• ACQUITY UPLC Columns Calculator (for methods transfer)
Additional firmware files in the folder “--- Firmware Updates ---”
• Connections Insight
• Waters Pump Control
• Deployment Manager
• ACQUITY UPLC Console
The systems and modules currently supported appear in the following tables.
Important: The
ACQUITY UPLC I-Class System
ACQUITY UPLC Systems June 2011 Driver Pack installer does not install the newest version of the firmware, even though it is included on the media (version 1.50 instead of 1.51, for example). After installing the June 2011 Driver Pack, you must manually install the newest version. For details, refer to the installation instructions on page 16.
Modules Part Number Software Version
Firmware Version
Firmware Checksum
ACQUITY UPLC I-Class BSM
186015000 1.50 1.50
ACQUITY UPLC I-Class SM-FTN
0x3ACBD4A5
186015046 1.50 1.50 (newer version available)
ACQUITY UPLC I-Class SM-FTN
0x3E83519D
186015046 1.50 0x377AE410 1.51
ACQUITY UPLC I-Class SM-FL
186015060 1.50 1.50 (newer version available)
ACQUITY UPLC I-Class SM-FL
0x66BA7F79
186015060 1.50 0x39374BCC 1.51
ACQUITY UPLC I-Class CH-A
186015042 N/A N/A
ACQUITY UPLC I-Class CM-A
N/A
186015043 1.50 1.50 (newer version available)
ACQUITY UPLC I-Class CM-A
0x19B6E386
186015043 1.50 1.51
0x19B50B4D
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ACQUITY UPLC H-Class/H-Class Bio Systems
Modules Part Number Software Version
Firmware Version
Firmware Checksum
ACQUITY UPLC H-Class QSM/ Bio QSM
186015018 186015041
1.50 1.50
ACQUITY UPLC H-Class SM-FTN / Bio SM-FTN
0xAE400516
186015017 186015040
1.50 1.50 (newer version available)
ACQUITY UPLC H-Class SM-FTN / Bio SM-FTN
0x3E83519D
186015017 186015040
1.50 0x377AE410 1.51
ACQUITY UPLC H-Class CH-A/H-Class Bio CH-A
186015042 N/A N/A
ACQUITY UPLC H-Class CM-A / H-Class Bio CM-A
N/A
186015043 1.50 1.50 (newer version available)
ACQUITY UPLC H-Class CM-A / H-Class Bio CM-A
0x19B6E386
186015043 1.50 1.51
ACQUITY UPLC H-Class CM-Aux / H-Class Bio CM-Aux
0x19B50B4D
186015049 N/A N/A
N/A
ACQUITY UPLC System
Modules Part Number Software Version
Firmware Version Firmware Checksum
ACQUITY UPLC BSM 186015001 1.50 1.50
ACQUITY UPLC SM
0x3ACBD4A5
186015005, 186015006
1.50 1.50 (newer version available)
ACQUITY UPLC SM
0x66BA7F79
186015005, 186015006
1.50 0x62CDAE6E 1.51
ACQUITY UPLC HTCH
186015010 N/A N/A
ACQUITY UPLC Column Heater
N/A
N/A N/A N/A
ACQUITY UPLC CM (Right Inlet)
N/A
186015007 1.50 1.40
ACQUITY UPLC CM (Left Inlet)
0x8F9312BD
186015009 1.50 1.40
ACQUITY UPLC Column Heater/Cooler
0x8F9312BD
186015008 1.50 N/A
N/A
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Detectors
Modules Compatible Systems
Part Number Software Version
Firmware Version
Firmware Checksum
ACQUITY UPLC TUV
All UPLC systems 186015028 1.50 1.50
ACQUITY UPLC TUV Thermally Enhanced
0xC09B9CB2
All UPLC systems 186015031 1.50 1.50
ACQUITY UPLC PDA
0xDBA6242F
All UPLC systems 186015026 1.50 1.51
ACQUITY UPLC PDA Thermally Enhanced
0xF1B095E6
All UPLC systems 186015032 1.50 1.51
ACQUITY UPLC eλ PDA
0xE6BBA016
All UPLC systems 186015030 1.50 1.51
ACQUITY UPLC eλ PDA Thermally Enhanced
0xF1B095E6
All UPLC systems 186015033 1.50 1.51
ACQUITY UPLC FLR
0xE6BBA016
All UPLC systems 186015029 1.40 1.40
ACQUITY UPLC ELSD
0xDFF5C6F9
All UPLC systems 186015027 1.40 1.40
Waters 2420 ELS Detector
0x216F9370
Waters HPLC Systems
186002420 1.40 1.30
Waters 2424 ELS Detector
0x21A5BED0
Waters HPLC Systems
186002424 1.40 1.30
Waters 2998 PDA Detector
0x21A5B8D0
Waters HPLC Systems
186002998 1.30
1.40 (download
from Waters.com)
Waters 2489 UV/Visible Detector
0x1AA04214
Waters HPLC Systems
186002487 1.31
1.40 (download
from Waters.com)
SQ Detector
0xE447C04B
All UPLC systems Empower-controlled systems: 1.40.1435
176000872 N/A
TQ Detector
N/A
All UPLC systems Empower-controlled systems: 1.40.2335
176001263 N/A N/A
Note: Version 1.40 of the firmware for the Waters 2998 PDA detector and version 1.40 of the firmware for the Waters 2489 UV/Visible detector are not included with this driver pack. Download these firmware versions from Waters.com.
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Accessories
Modules Compatible Systems
Part Number
Software Version
Firmware Version
Firmware Checksum
Sample Organizer ACQUITY UPLC Systems only
186015020 186015021
N/A 1.50 (newer version
available)
Sample Organizer
0x98B4D459
ACQUITY UPLC Systems only
186015020 186015021
N/A 0x98ADABF7 1.51
Sample Organizer ACQUITY UPLC I-Class / ACQUITY UPLC H-Class and H-Class Bio Systems
186015014 N/A 1.50 (newer version
available)
Sample Organizer
0x98B4D459
ACQUITY UPLC I-Class / ACQUITY UPLC H-Class and H-Class Bio Systems
186015014 N/A 0x98ADABF7 1.51
ACQUITY UPLC 30-cm Column Heater/Cooler
All UPLC Systems 186015011 N/A N/A
ACQUITY UPLC CH-30A
N/A
ACQUITY UPLC I-Class / ACQUITY UPLC H-Class and H-Class Bio Systems
186015045 N/A N/A
Column Manager Auxiliary Units
N/A
ACQUITY UPLC H-Class and H-Class Bio Systems
186015049 N/A N/A
Local Console Controller
N/A
All UPLC systems 725000464 1.51 N/A
N/A
Additional Software
Software Compatible Systems Software Version
Connections INSIGHT All UPLC systems
ACQUITY UPLC Columns Calculator
3.1
All UPLC systems
Deployment Manager
1.50
All UPLC systems
Waters Pump Control Software
3.0
All UPLC systems
ACQUITY UPLC Console
2.20
All UPLC systems
Microsoft .NET Framework
1.51
All UPLC systems 3.5
Note: The 3100 Mass Detector is supported with ACQUITY UPLC H-Class systems, but its software is not included on this DVD. Refer to the 3100 Mass Detector installation media for details.
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See also:
• ACQUITY UPLC, ACQUITY UPLC H-Class, and ACQUITY UPLC H-Class Bio System Documentation Set CDs
• ACQUITY UPLC Console Online Help
• ACQUITY UPLC Systems January 2010 Release Notes
• ACQUITY UPLC Systems June 2010 Release Notes
• ACQUITY UPLC Systems June 2010 Supplemental Driver Pack II Release Notes
• Controlling Contamination in Ultra Performance LC/MS and HPLC/MS Systems
Limitations
This release does not apply to nanoACQUITY UPLC
®
The ACQUITY UPLC H-Class and H-Class Bio systems are supported for use with the SQ and TQ mass spectrometers. The ACQUITY UPLC H-Class system is also supported for use with the Waters 3100 mass spectrometer.
systems.
Hardware and Software Requirements
Supported Waters hardware: • ACQUITY UPLC System
• ACQUITY UPLC H-Class System
• ACQUITY UPLC H-Class Bio System
• ACQUITY UPLC I-Class System
• ACQUITY UPLC Systems with 2D Technology (For details, refer to the ACQUITY UPLC Systems with 2D Technology Release Notes.)
Supported Waters and third-party software
System Empower 1154: ACQUITY Service Pack to SP M (English and Japanese)
Empower 2: base release to SP H (English, Chinese, Japanese, and Korean)
Empower 3 MassLynx (see list of SCNs, below)
Standalone ACQUITY Console
Analyst
ACQUITY UPLC System
®
Yes Yes Yes Yes Yes
Versions 1.4.2, 1.5.0, and 1.5.1
ACQUITY UPLC H-Class System
Yes Yes Yes Yes Yes No
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System Empower 1154: ACQUITY Service Pack to SP M (English and Japanese)
Empower 2: base release to SP H (English, Chinese, Japanese, and Korean)
Empower 3 MassLynx (see list of SCNs, below)
Standalone ACQUITY Console
Analyst
ACQUITY UPLC H-Class Bio System
®
No Yes Yes Yes Yes No
ACQUITY UPLC I-Class System No Yes Yes Yes Yes
Versions 1.4.2, 1.5.0, and 1.5.1
• Compatibility information about third-party control software, as published by the software developer.
Refer to the following sources:
• Page 8 for a list of MassLynx software change notes compatible with this release.
Requirement:
Backward Compatibility
If an SQ, TQ, or 3100 mass spectrometer is part of the system, you must install, at a minimum, Empower 2 Feature Release 4. Note that the Empower 2 System Suitability option is required.
• Existing ACQUITY UPLC methods are compatible with the new I-Class System.
• This software does not support existing MassLynx methods for ACQUITY UPLC systems that include column managers. Because column managers are now configured as detectors in MassLynx, you must re-create your methods.
• When using Empower 1154 or Empower 2 on a system containing CM-A and CM-Aux modules, you cannot select positions 5 and 6 from the column selection field of the sample queue. Instead, create an instrument method for a specific column position (5 or 6, for example) and save it with a unique name. From within your sample queue, select the appropriate method set (that includes the instrument method you created) to specify the column position.
Supported operating systems
• The Waters web site, for software release notes that include details on test configurations, operating systems, service packs, and hotfixes.
Refer to the following sources:
• Empower and MassLynx Release Notes, for additional information on supported operating systems for servers in workgroup or enterprise environments
• Empower Service Packs and Feature Releases
• MassLynx Service Packs and software change notes
Recommendation: Upgrade your Instrument LAN network card drivers to the most recent version when running this software on a supported Empower workstation. Consult the network card's manufacturer for the most up-to-date network card drivers.
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• For this release, a standalone or acquisition client workstation is supported only with a single MS-based system.
Notes:
• Waters publishes incremental information on operating system and hotfix support to the Services and Support area of its web site.
ACQUITY UPLC minimum hardware requirements and maximum detector data rates
For Intel® Pentium®
• 2 PDA detectors at 80 Hz, 210-400 nm, 4.8 nm, normal (0.05 sec), 2-Absorbance or Fluorescence 2D channels, 2-MBF 2D channels, 30 minutes run time; Empower's Run and Report Mode.
IV 2.8 GHz Processor, with 800 MHz FSB and 1 GB of RAM, one of the following sets of specifications can apply:
• 2 PDA detectors at 40 Hz, 210-400 nm, 1.2 nm, normal (0.10 sec), 2-Absorbance or Fluorescence 2D channels, 2-MBF 2D channels, 30 minutes run time, Empower's Run and Report Mode.
Important: These specifications fit Waters Configuration 10, 11, and 12 LAC/E32
For Intel Pentium IV 1.7 GHz Processor with 400 MHz FSB and 1 GB of RAM, one of the following sets of specifications can apply.
Acquisition Servers. Configuration 10 systems require a memory upgrade.
• 2 PDA detectors at 20 Hz, 210-400 nm, 1.2 nm, normal (0.20 sec), 2-Abs 2D channels, 2-MBF 2D channels, 30 minutes run time, Empower's Run and Report Mode.
• 4 TUV detectors at 80 Hz, MBF enabled, 60 minutes run time, Empower's Run and Report Mode.
Important: These specifications fit Waters Configuration 8, 9, 10, 11, and 12 LAC/E32
Installing the ACQUITY UPLC Systems June 2011 Driver Pack Release
Acquisition Servers. Configuration 8, 9, and 10 systems require a memory upgrade.
Caution: To avoid damaging the needle, when upgrading from ICS version 1.45, recalibrate the seal and z axis of the SM-FTN after installing this release.
Important: If you are using real-time virus scanning, after installation, exclude all Empower-related folders and their sub-directories from the scans. Some real-time virus scanners mistake normal Empower functionality for virus activity and can therefore interfere with data buffering.
Requirement: Customers with Empower Enterprise systems who have both ACQUITY UPLC and ACQUITY UPLC H-Class systems must update all ACQUITY Instrument Control Software (ICS) implementations in their environment to the June 2011 Driver Pack. Mixing of ACQUITY UPLC ICS versions is not supported with the ACQUITY UPLC Systems June 2011 Driver Pack.
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Installation method You can install this software release according to one of these methods:
• The DVD provided with this document.
• Downloading from the Waters Web site. To do so, visit http://www.waters.com/waters/home.htm, and click Services & Support > Support > Software Downloads (support plan required).
Recommendation: Remove the Internet information system (IIS) for the local console controller when upgrading from firmware version 1.00 to this release (the default Web site has been disabled).
Note: Push installation is now supported using PsExec for all ACQUITY®
To install or upgrade the ACQUITY UPLC Systems June 2011 Driver Pack:
(non MS) modules.
1. Exit all applications, and restart the computer.
2. Run Setup.exe on the DVD.
3. On the Welcome page of the setup wizard, click Next, and then select Install / Upgrade.
4. Accept release notes message and software license.
Result: The Deployment Manager – Instrument Component Software page for your system appears.
Tip:
5. Select the drivers for the instruments that you want to install, and then click Next.
For a MassLynx-controlled ACQUITY UPLC system, the SQ and TQ detectors do not appear in the deployment manager. Instead, select the instruments during MassLynx installation.
6. Click Install, and then wait for the process to finish.
7. Click Finish.
Note: If prompted, select Yes to restart the computer.
Result:
Tips:
The Waters Autoloader, which selects the instruments or devices that require firmware upgrades, is automatically launched.
• To see versions and checksums, scroll to the right. • To see the location where the firmware is installed on a hard drive, hover the pointer over
the instrument or device name. • If the firmware version installed on an instrument appears as “Unknown” in the Autoloader,
no firmware files for that instrument are present on the host PC.
8. Click Load Firmware, to start the autoloader loading all selected firmware.
Tip:
For Empower installations, ACQUITY instrument support is installed in C:\Empower\Instruments.
The Waters Autoloader simplifies installing the release software. It automatically detects the presence of compatible software and installs the appropriate support for your ACQUITY configuration. By default, the installer appears in the language of your workstation settings.
For all other installations, ACQUITY instrument support is installed in C:\Program Files\Waters Instruments.
Result: When the status is Cycle Power, the firmware is installed.
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Caution: To avoid corrupting the firmware, do not cycle power to any system module until firmware for all modules is installed.
Tip:
• A PC running Empower: C:\Empower\Instruments\Firmware
If the Autoloader application does not begin to load the firmware, or if it fails to successfully complete the process, re-run autoloader.exe from one of the following locations:
• A PC running MassLynx (or other data system): C:\Program Files\Waters Instruments\Firmware
9. When the status of all system modules is Cycle Power, restart each module.
10. When the status of all system modules is Load Complete, click OK, and then restart the computer.
Using the repair function If an earlier ACQUITY UPLC CD or DVD (or a non-ACQUITY CD or DVD) is used to install an instrument driver, use the ACQUITY UPLC Systems June 2011 Driver Pack media “Repair” feature in the Deployment Manager (DM) to reconcile any incompatibility you might have introduced.
Caution: To avoid introducing incompatible versions of drivers, install older drivers before newer drivers. If you encounter a compatibility problem, use the “Repair” feature in the ACQUITY UPLC June 2011 Driver Pack Deployment Manager (DM).
If any ICS from ACQUITY UPLC June 2011 Driver Pack is installed, the “Repair” feature will be enabled on the system.
If an incompatibility is found, restart the computer.
If no ICS from the ACQUITY UPLC June 2011 Driver Pack is installed, you can run the “Repair” function from the DM:
1. Exit all applications.
2. Run Setup.exe on the DVD.
3. Click Next.
4. Click Repair, and then click Repair again.
5. Restart the system.
Installing the Updated Firmware Release Since the original release of the ACQUITY UPLC June 2011 Driver Pack, the firmware for the ACQUITY UPLC sample managers, the ACQUITY UPLC Sample Organizer, and the ACQUITY UPLC Column Manager with Active Preheater has been updated. To install this newer firmware, follow the instructions, below.
See also: For more information about the updated firmware, please consult the firmware release notes contained in the “--- Firmware Updates ---“ folder on the ACQUITY UPLC June 2011 Driver Pack (Revision B) media.
To install the updated firmware release:
1. Reboot the sample manager, sample organizer, and column manager.
Tip: If installing sample organizer firmware, deconfigure the sample organizer from the sample manager before loading firmware.
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2. Run ”ACQUITY Sample Managers v1.51.exe” or “ACQUITY Column Manager II v1.51.exe” from the “--- Firmware Updates ---“ folder (Windows 7 users must right-click the file and select "Run as administrator"), and unzip the files to one of the following locations, depending on whether the operating software is Empower or MassLynx:
• For Empower: C:\Empower\Instruments\Firmware
• For MassLynx on Windows XP: C:\Program Files\Waters Instruments\Firmware
• For MassLynx on Windows 7: C:\Program Files (x86)\Waters Instruments\Firmware
3. When asked to overwrite files, select Yes.
4. Navigate to the location you selected in step 2, and run Loader.exe.
5. On the Welcome page, select Scan for instruments.
6. Select the instrument you are updating, and then click OK.
Result:
7. In the Select the File to Load window, click Browse, to find and select the appropriate .sft file from the location you selected in step 4:
The Select the File to Load window opens.
• For an ACQUITY UPLC Sample Manager, select “ACQUITY Sample Manager.sft”.
• For an ACQUITY UPLC Sample Manager - FL, select “ACQUITY Sample Manager FL.sft”.
• For an ACQUITY UPLC Sample Manager - FTN, select “ACQUITY Sample Manager FTN.sft”.
• For an ACQUITY UPLC Sample Organizer, select “ACQUITY Sample Organizer.sft”.
• For an ACQUITY UPLC Column Manager-A, select “ACQUITY Column Manager II.sft”.
8. Click Next to begin loading the firmware.
When firmware loading is 100% complete, click Finish, and then reboot the instrument.
Installing this Release in an Empower Enterprise Environment
Requirement:
For consistency, install the driver/firmware on all clients, LAC/E
Customers with Empower Enterprise systems who use both ACQUITY UPLC and ACQUITY UPLC H-Class systems must update all ACQUITY instrument control software (ICS) implementations in their environment to the June 2011 Driver Pack. The ACQUITY UPLC Systems June 2011 Driver Pack does not support mixed use of ACQUITY UPLC ICS versions.
32 modules, and Citrix application servers. You need not install the driver/firmware on the database server unless Client software is loaded on the server to interact with the instrument or device. On an Empower Enterprise (Client/Server) system, install the driver/firmware according to the preceding instructions. You must do so on every computer (LAC/E32 module, client, and Citrix®
In workgroup and enterprise environments, MS acquisition is supported via acquisition clients only. LAC/E
application server) that interacts with the instrument or device.
32
For information on Empower Enterprise server systems or Citrix server systems, refer to the
acquisitions are not supported.
Waters Empower 2 Feature Release 5 Release Notes, Waters Empower 2 Service Pack D Release Notes, or Empower 2 Feature Release 4 Release Notes.
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Installing Empower ICS on a Citrix server Requirement:
You can install the Empower ICS on a Citrix server in one of two ways: via the command line or by adding or removing software.
Customers with Empower Enterprise systems who use both ACQUITY UPLC and ACQUITY UPLC H-Class systems must update all ACQUITY instrument control software (ICS) implementations in their environment to the June 2011 Driver Pack. The ACQUITY UPLC Systems June 2011 Driver Pack does not support mixed use of ACQUITY UPLC ICS versions.
To install Empower ICS on a Citrix Server using the command line:
1. Change user/install.
2. Install software via the setup.exe on the June 2011 Driver Pack DVD.
3. Change user/execute.
To install Empower ICS on a Citrix Server by adding or removing software:
1. Insert the ICS disk into the media drive.
2. Open the computer’s control panel, and double-click Add/Remove Programs.
3. Click Add New Programs.
4. In the Run Installation Program dialog box, click Browse.
5. Browse to the location where the media is installed.
6. Select the setup.exe file, and then click Open.
Tip:
7. Follow all prompts, to finish the installation.
It can be necessary to select “All Files” from the “Files of type” list.
8.
Tip: It is necessary to ensure the Local Windows Administrator level privilege is used on the Citrix server for access to directories and registry keys to be successful .
To verify a successful installation, the C:\Windows\Empower.log file must contain this entry below after the Deployment Manager has run:
9.
"The ICS configuration completed successfully....."
In some cases, the following DOS command line can be executed on the Citrix server if the ICSCompanionService has not installed correctly. From the path where the ICSCompanionSetup.exe is located, type the following string:
Troubleshooting and Uninstalling
ICSCompanionSetup.exe /v"SKIP=TRUE ALLUSERS=1".
If the installation fails, uninstall previous versions.
To uninstall previous versions of the software:
1. Exit all applications and restart the computer.
2. Run Setup.exe, on the DVD.
3. Select “Remove”, to remove the previously installed instruments, and then click Next.
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4. Select all of the instruments and devices you want to remove, and then click Next.
5. Click Finish.
6. Restart the computer.
7. Repeat the installation procedure.
ICS Companion
Overview The ICS Companion service monitors and manages the deployment of Waters-developed drivers and related utilities. The service resolves various problems associated with installing older drivers, which, if not installed in a particular order, can sometimes compromise the functionality of newer drivers.
The operation of some older drivers and utilities differs regarding the manner in which they deploy shared components and configurations. The ICS Companion ensures that shared components are compatible with respect to different driver releases, regardless of their order of installation.
Delivered with newer drivers by the deployment manager, the ICS Companion continuously monitors subsequent legacy installations for potential incompatibilities, which, on encountering, it resolves.
A minor defect (D-25201) in the current version of the ICS Companion affects the header of Empower software's Verify Files report. The service fails to list some previously installed drivers and utilities, such as the Waters HCO v2.0. Significantly, the defect's effect extends only to the missing header section of the Verify Files report. The actual driver software loads correctly and becomes fully operational. In no case does the ICS companion uninstall another driver or other software component.
The following figure illustrates how the defect affects the header of the Verify Files report: a new instrument driver (Agilent LC) was installed, and the header is incomplete:
Before new install
After new install
Present before the “Agilent LC” install but…
Missing the 2420, 2424, CCAD, and HCO in new header
Installed “Agilent LC”
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The following example shows that only the header is affected and the detail content displays correctly.
Technical information The ICS Companion scans the registry keys under HKLM\SOFTWARE\Waters\Instruments\Setup and validates the installation. If an installation is not found, the value for "Installed" will be set to "0".
Installation validation The ICS companion reads the value of "LocaleName" under HKLM\SOFTWARE\Waters\Instruments\Setup\ICS and if the LocaleName value name does not exist, the companion uses the ICS (registry key) as the product name and validates it with the installed products under HKCR\Installer\Products\ProductName.
Workaround Add a string value named "LocaleName" under HKLM\SOFTWARE\Waters\Instruments\Setup\ICS and assign the product name for its “value”.
ICS - Instrument name, example “Waters CCAD” or “Waters HCO v2.0”
Disabling the service The ICS Companion service can be safely disabled with no impact other than the loss of protection of potential incompatibilities with legacy drivers that are installed later.
1.
Disabling the ICS Companion service should be executed by an administrator using the following three steps from the Windows command line.
2.
sc stop WatersICSCompanionSvc
3.
sc config WatersICSCompanionSvc start= disabled
sc config WatersICSCompanionSvc start= disabled
No change in actual content
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Restoring an SQ and TQ Empower 2 project for use with IntelliStart
During installation of the instrument driver, a template project is installed to this subdirectory: “<Drive Letter>\Empower\Instruments\Projects”.
The installer creates a new Projects subdirectory under the file path <Drive Letter>\Empower\Instruments. It then copies the supplied project to the subdirectory.
To use the IntelliStart functionality, you must restore the supplied project for your detector in Empower 2, which contains the appropriate methods for a detector to run IntelliStart. You must use the supplied project to clone all future projects.
The supplied instrument methods are based on a chromatographic system consisting of the TQ or SQ detector, along with the ACQUITY UPLC Quaternary Solvent Manager and the ACQUITY UPLC Sample Manager–Flow Through Needle. If your configuration differs, modify the instrument method to include all modules configured in the current chromatographic system. Add additional system hardware to the instrument method using the Add Instrument option. Refer to the Empower online Help for information on adding instruments to a method.
Once a project is restored, right-click it, and select Project Properties. From the Project Properties dialog box, clear the Dissolution, GPC, GPCV, and Chemical Structures check boxes. Leave all other properties at their default values.
• Empower or Empower 2 online Help, for further details about restoring projects, cloning projects, and user privileges.
See also:
• Empower 2 Installation and Configuration Guide, for details about workstation and server setup.
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Defects addressed by this release The following table contains a list of the software problems corrected in this release. The PCS (product change system) numbers identify software issues that Waters personnel monitor within a system change request tracking tool.
Module PCS Number
Description
Analyst 19238 While running a sample queue, the system no longer stops functioning properly when you abort a sample.
Analyst 19689 Analyst software retains the ACQUITY login information of a user that is logged off.
Analyst 19846 You cannot disable and then enable the hardware profile within Analyst without losing the ability to run a method.
Analyst 20346 Analyst does not function normally when the system’s mass spectrometer is in Standby mode.
Analyst 21314 After you click Stop Flow in the ACQUITY Console, you cannot restart a sample run in Analyst.
ACQUITY Console
21337 When Empower software is running, the System Startup pages are occasionally blank.
ACQUITY Console
21670 In MassLynx, if you ignite the lamp via the ACQUITY Console at the top level, the lamp icon changes to green, while the Inlet editor’s icon remains red; the lamp control button also suggests that the lamp did not ignite.
BSM 19329 BSM Console plots (Japanese language only) do not display a unit of time.
CM-A 21737 The column manager occasionally becomes unresponsive, resulting in a communications failure.
CM-A 22671 The column manager does not properly transition between changes in column and selection pump flow rates.
CM-A 24536 Column manager methods created with the ACQUITY UPLC Systems June 2010 Driver Pack and June 2010 Supplemental Driver Pack (versions 1.45 and 1.46) are not compatible with the June 2011 Driver Pack (version 1.50).
CM-A 24540 If the column manager is set to “Bypass” when running under Empower control, a “Sample Set failure” error message appears.
PDA 18612 The shutter does not close when the Read Energy diagnostic completes.
PDA 19317 The Reference Compensation Channel is not reported correctly in Empower Reports.
PDA 21021 You cannot use a comma as a decimal separator, if supported by your regional settings.
PDA, TUV 20939 The installation date is not automatically updated upon installation of a new lamp.
PDA, TUV 18868, 21146
If the lamp is extinguished when a new sample queue was started, the system occasionally initiates the injection before the lamp is ignited and stable.
SM 18735 The wash needle function fails if the total wash volume is programmed over 2500 µl and generates a "Not enough volume left in Wash Syringe" message during operation.
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Module PCS Number
Description
SM 25234 The sample manager fails to function correctly when a high-temperature column heater and a 30-cm column heater/cooler are both connected to the instrument using a Y-cable.
SM 25254 The sample manager moves the needle and continues with injections when the sample compartment door is open.
SM 25394 When using load-ahead mode, a sample manager communications failure occasionally occurs. Workaround: Installing the ACQUITY UPLC Sample Managers Firmware, version 1.51.
SM-FL, SM-FTN
25449 The rotary tray occasionally moves when the door is open and the plate tray is extended.
SM-FL, SM-FTN
24669 The sample manager's firmware can stop working and require rebooting when the following three conditions are met simultaneously:
1. The sample manager’s rotary tray is in motion, to cool the tray. 2. A plate is moving between the sample manager and sample
organizer. 3. An alarm is triggered, or a user aborts a process.
SM-FL, SM-FTN
24859 The sample manager firmware triggers a column-temperature alarm when a shorted circuit affects the sample compartment's heat-sink temperature sensor.
SM-FL, SM-FTN
25436 When the sample manager is idle, the needle moves between the “inject” and “load” positions every 30 minutes.
SM-FL, SM-FTN
24285 The R-Axis Calibration service diagnostic, added in ACQUITY UPLC Systems June 2011 Driver Pack, allows robust support for the 384/100 µL wellplates and proper needle positioning for ACQUITY UPLC I-Class SM-FTN and SM-FL injectors.
SM-FL 25161 After a running sample set is aborted, the sample manager needle stops working. To regain function, power-off and then power-on the device.
SM-FTN 22042 SM-FTN firmware includes a modification that addresses an increase in the minimum temperature of the sample chamber heat sink, from -0.5 °C to 0 °C. The increase in temperature eliminates the potential icing of the heat sink.
SM-FTN 19943 The standalone Console software can now accept column temperature settings above 65 °C for a compatible column heater.
SM-FTN 20645 The SM-FTN stops the injection in error if a vial specified by auto addition is missing. This action avoids wasting sample from the other vials which are present.
SM-FTN 21632 Repeatedly opening and closing the sample compartment door could result in an incorrect temperature setting.
SM-FTN 21732 An incorrect SM-FTN extension loop size appears in the Post Run Report.
SM-FTN 22715 Auxiliary vials do not honor the “Skip Missing Vial” configuration feature on the SM-FTN.
SM-FTN 22924 Detection of tray loss-of-sync has been rendered less sensitive to avoid errors from insignificant misalignment.
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Module PCS Number
Description
SO 25300 The ACQUITY UPLC Sample Organizer Firmware, version 1.50, causes a change in the z axis alignment to the y axis transfer shuttle. The misalignment causes the improper transfer of plates along the y axis and the related error message, "Transfer Shuttle homing error", appears.
TUV 21848 When you specify a second switch in the method for an instrument or device that to which only one physical switch applies, the instrument or device can become unresponsive.
Known defects in this release The following table shows known software defects and, in some cases, workarounds for this release. The PCS (product change system) numbers identify software issues that Waters personnel monitor within a system change request tracking tool.
Module PCS Number
Description
Empower 25201 When using the “Verify Files” function of Empower, the heading information does not include all previously installed drivers and utilities.
BSM 24160 On an Empower Enterprise (client/server) system, the control panel for the BSM fails to appear. Recommendation: Verify that the DCOM permissions are configured correctly:
• For Empower 2 systems, consult Waters Configuration Notes for Empower 2 Enterprise Server on Windows 2003 Server SP1 and R2.
• For Empower 3 systems, consult Empower 3 Installation and Configuration Guide.
CH-30A, CH-A
25919 The SM-FTN supports the monitoring of three leak sensors: • its lower leak sensor, • its upper leak sensor, • and the leak sensor of an attached CH-30A or CH-A.
If a leak sensor is installed in an attached CH-30A or CH-A, the upper leak sensor of the SM-FTN must also be installed. Otherwise, a leak detected alarm will be raised that cannot be cleared. At this time, it is not possible to install a leak sensor in an attached CH-30A or CH-A without also installing the SM-FTN's upper leak sensor.
CM 24232 The “Shut down all columns" option is not supported for the CM. (This option is only for systems that include a CM-A.) Workaround: To turn the temperature setting off in the method editor, set the column field to "0" or "off".
CM-A 21637 Reading up to six eCords results in a lengthy column information upload delay. Attempting to edit comments when the eCord™ is still in reading mode can cause the Console to stop functioning properly.
CM-A 23589, 23762
Following reboot of the console after a CM-A configuration change, columns can appear to be missing from the CM-A tree. Recommendation: Restart the CM-A, and then the Console software.
CM-A 23993 Clicking Column QC or Batch QC multiple times while in reading mode can cause the Console software to stop functioning properly.
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Module PCS Number
Description
LCC 23472 If using a Domain account, connection with LCC is not possible. If the Local System account is used, connection with LCC is possible. Workaround: If a domain account is starting WatersService, that account must have local administrative privileges.
MassLynx 23983 When running MassLynx with SCN 714 and SCN 733, enabling more than 16 data channels can cause MassLynx to stop functioning properly. Do not enable more than 16 data channels.
SM-FL 24336 Before performing a seal calibration diagnostic test on a system that includes an SM-FL, you must remove all sample plates.
SO 24189 In the sample organizer’s Console interactive control screen, the unload valve status text states “open” regardless of the actual valve status. Note: This is defect affects only the displayed text; the valve itself opens and closes correctly.
ACQUITY UPLC System Qualification
Requalification Guidelines This Instrument Control Software (ICS) package includes software and firmware that is to be loaded onto your Chromatography Data System (CDS) and laboratory instrument. As with any change in a GxP environment, follow your organization's standard operating procedures for managing software changes.
The following approaches can be used to verify the indicated functionalities:
• To confirm that the ICS software installation has not affected any critical CDS files and that the new files have loaded properly, you can perform a software Installation Qualification (IQ) using ConnectionsAQT for Software, Empower SystemsQT for Software, or a MassLynx IQ workbook as appropriate on each computer where the software has been added.
• To verify the instrument module's operation with the newly loaded firmware, you can perform an Operational Qualification (OQ) of the affected instrument module.
• To verify the computerized system’s ability to communicate with and control your instrument system, you can conduct a system Performance Qualification (PQ) or System Suitability test.
Where numerous identical systems are involved, a risk-based approach to qualification activities may be an important consideration.
Requalifying the software and hardware when upgrading is covered under the Total Assurance Plan with Qualification Option in the following scenarios:
• During yearly requalification under the plan. • If loading the release is required for operation of a new module or system, qualification of the new
module or system is covered.
For situations not covered under the plan, Waters can still perform the qualification, but additional charges apply.
Contacting the Waters Technical Service Organization If you are located in the USA or Canada, report malfunctions or other problems to Waters Technical Service (800 252-4752). If you are located elsewhere, phone the Waters corporate headquarters in Milford, Massachusetts (USA), or contact your local Waters subsidiary. Our Web site includes phone numbers and e-mail addresses for Waters locations worldwide.
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