ACKNOWLEDGEMENT

I express my unfathomable gratitude to my supervisor

Dr.D.Haripriya, M.Sc., Ph.D., Former Assistant Professor, Department of Medical

Research, SRM University, Kattankulathur, for her excellent guidance, thought

provoking discussions, constructive criticism and unwavering encouragement in

every step of the study.

It is my privilege and pleasure to thank Dr.V.Ponnvaiko, Vice Chancellor,

SRM University, Kattankulathur for his kind attention and encouragement.

I like to extend my thanks to Dr.Thangaraju, Pro Vice Chancellor, SRM

Medical College, Hospital & Research Center, SRM University for his kind

attention.

I also like to extend my thanks to Dr.D.Balakrishnan, Dean Medical

Research, SRM Medical College, Hospital & Research Center, SRM University for

his kind attention and encouragement in my progress.

I am very thankful to Prof. N. Seethuraman, Registrar, SRM University,

Dr. James Pandian, Dean Medical, Dr. Narayana Rao, Director Research and

Dr.Kashmir Raja, Dean Research, SRM University for the invariable support and

encouragement.

I will fail in my duty if I forget to thank Dr.Vinod Kochupillai, Former

Director Medical, SRM Medical College Hospital & Research Centre for her

profound support and concern.

I am very thankful to my external doctoral committee members,

Dr.P.Kalaiselvi, Senior Lecturer, Department of Biochemistry, PGIBMS, Taramani

and Dr.S.Shila, Research Scientist, VRR Diagnostic service and Research centre.

I also personally thank my internal doctoral committee members,

Dr. Rajagopalan, Professor and Head, Department of Dermatology and

Dr. Ebenezer William, Professor and Head, Department of Biochemistry, SRM

Medical College Hospital & Research Centre for their valuable suggestions and

support.

I also thank Dr. Annabelle Rajaseharan for her valuable suggestions and

comments. I personally thank Dr. Pushpa Gnanaraj and Dr. Subhashini,

Dermatologist, SRM Medical College Hospital & Research Centre for recruiting

psoriasis patients for this study.

I extend my thanks to the Dr.S.Sundaresan,

Dr. P. Venkataraman and Dr. Kanchanamala, Assistant Professors, Department of

Medical Research, SRM Medical College Hospital & Research Centre for their help

and support.

I also express my sincere gratitude to Dr. P. Ganeshkumar, Assistant

Professor, Department of Community Medicine, SRM Medical College Hospital &

Research Centre for his help and support in statistical analysis. I am also grateful to

Mr.Pazhanimuthu, Ramachandra University, for his kind help to do Real Time

PCR.

I am also very thankful to all Teaching and Non teaching staffs of the

Department of Biochemistry, SRM Medical College Hospital & Research Centre for

their support.

I acknowledge the kind help of research scholars, Mrs.S.Swapna,

Mrs. M.Hemamalini and Mr.E.Purusoth and also other research scholars for their

kind co-operation and maintaining a friendly atmosphere.

I also thank my Mr.Valuvan, Technician, Department of Anatomy, SRM

Medical College Hospital & Research Centre for his technical help. I also thank the

Staff nurses, Department of Dermatology and Technicians, Central Laboratory,

SRM Medical College Hospital, who was highly supportive throughout.

I am grateful to my colleague’s Mr.B.Prabhu,

Mr. A.Shivakumar, Ms. Kalaiselvi , Ms. Padma and Mr. Sathish for their

constant support and timely help during my project work. I also thank

Ms. Aisha and Mrs. Archana, Computer operators, Department of Medical

Research, SRM Medical College Hospital & Research Centre for their help and

support

I would like to thank my friends Mrs.K.Amuthavalli, Mrs.G.Lavanya and

Dr.S.Sivakumar for their cheering company at all times.

I am gratified to all the PSORIASIS PATIENTS who kindly gave up their

time and skin to help with this work. Without their dedication and willingness to

participate, the work would have not been possible.

It is my great pleasure to thank my Parents, Brothers,

and my Sister in laws for their care and continuous encouragement throughout my

education.

I am also grateful to Mrs. Shanthi V., M/s. Adyar Students Xerox Pvt.

Ltd., for their cooperation and timely help throughout my thesis.

I extend my sincere thanks to all, those who helped me during the course of

study.

E. TAMILSELVI