AccommodationAccommodation in the new University Residences is advised. Each room is provided with private bathroom. Details of prices are shown on the on-line application form (€ 50 deposit is required). Accommodation will also be possible in Camerino or nearby hotels, 5-15 km from the Symposium center (please visit the website for details). However, no bus service is planned and the use of one's own car is advised. Participants interested in hotel accommodation may contact the hotels directly.

Correspondence AddressSecretariat 16th Camerino-Noordwijkerhout SymposiumDipartimento di Scienze ChimicheUniversità di CamerinoVia S. Agostino, 162032 Camerino, ItalyTel.: ++39 0737 402239/402237/402223Fax: ++39 0737637345e-mail: secretariat.camerino@unicam.it

Further information and on-line registration and accommodation forms are available at:

http://www.unicam.it/farmacia/symposium/index.html

Deadlines to RememberApril 30, 2007 Submission of AbstractsMay 31, 2007 Early Registration May 31, 2007 Room Reservation

Lunch and RefreshmentsCoffee and tea will be available throughout the meeting. Meals will be taken at the University restaurant (self-service).

TravelParticipants are requested to make their own travel arrangements. However, a free bus will be provided to connect Rome international airport (Leonardo da Vinci) with Camerino on Sunday September 9, 2007 (fill in the on-line application form). The bus will leave the airport at 2 p.m.

Scientific CommitteeN. Birdsall (UK), L. Brasili (Italy), D. Donati (Italy), G. Gaviraghi (Italy), M. Giannella (Italy), R. A. Glennon (USA), F. Gualtieri (Italy), R. Leurs (The Netherlands), C. Melchiorre (Italy), R. Pellicciari (Italy), G. Ronsisvalle (Italy), H. Timmerman (The Netherlands), D. J. Triggle (USA).

Organizing CommitteeP. Angeli, M. Buccioni, F. Gentili, M. Giannella, D. Giardinà, G. Giorgioni, U. Gulini, G. Marucci, A. Piergentili, M. Pigini, W. Quaglia, G. Sagratini.

Scientific CommunicationsThe program includes one poster session. Posters will be subjected to a selection procedure. Abstracts have to be prepared using the on-line template (http://www.unicam.it/farmacia/symposium/Abstract07.doc) and e-mailed to abstract.camerino@unicam.it not later than April 30, 2007. Abstracts received by fax or mail will not be considered. Accepted communications will be copied directly into the abstract book. Notification of acceptance will be communicated to the author by June 2007. The scientific committee will select a number of abstracts for presentation as short oral communications. Participants wishing to accept such an invitation should indicate this on the application form.

Under the sponsorship of Medicinal Chemistry Division of the Italian

Chemical Society (SCI) andEuropean Federation of Medicinal Chemistry

(EFMC)

European Federation European Federation of Medicinal Chemistryof Medicinal Chemistry

Medicinal Chemistry Division Medicinal Chemistry Division of Italian Chemical Societyof Italian Chemical Society

Dates and Location The 16th Camerino-Noordwijkerhout Symposium will be held in the “Sala della Muta” of the Palazzo Ducale - Camerino, from 9 to 13 September 2007.

Symposium BureauThe Symposium bureau will be open from 2 p.m. to 8 p.m. on Sunday, 9 September 2007, and thereafter daily from 8 a.m. to 6 p.m.

LanguageThe official language of the Symposium will be English.

Opening: Multifunctional Drugs – C. Melchiorre (I)

Pain Treatment Development G. Ronsisvalle (I)The Endogenous Cannabinoids: New Major Players in Physiology - R. Mechoulam (IL); When Chemistry Mimics Physics. The Manipulation of TRP-V1 and Related Ion Channels by Small Molecules - G. Appendino (I); Chemical and Functional Bridges between Two Chemically Different but Functionally Related Types of Receptors: TRP Channels and Cannabinoid Receptors - V. Di Marzo (I); Recent Findings on Imidazoline Receptors - A. Hudson (CDN); Most Recent Findings on Sigma Ligands - J. Holenz (E).

Future Drugs For Neurodegenerative Diseases TreatmentH. Timmerman (NL)Purinergic Receptors and Neuroprotection - G. Cristalli (I); Aporphinoids as Building Blocks for Dopaminergic Agents - J. Neumeyer (USA); Histamine H3 Receptor Ligands - I. J. P. De Esch (NL).

Drug Targets: Finding and Validating Them D. J. Triggle (USA)The Druggable Genome – A. L. Hopkins (UK); Chemical Biology & Target Search – R. C. Flaumenhaft (USA); Chemical and Biological Descriptor Space: what Can We Learn from a Systematic Comparison? R. V. Stanton (USA).

Neglected and Emerging Serotonin Receptors and Their Selective Ligands D. Donati (I)Recent Findings on 5HT6 Receptor Ligands -

R. A. Glennon (USA); The 5-HT1F Receptor:

Pharmacology, Physiology, and Structure Activity Relationships - D. L. Nelson (USA); New Templates for Serotoninergic 5-HT1A Receptor - D. Graziani (I);

Selection and Evolution of a Lead Series During Its Optimisation: Novel Potent and Selective 5-HT2C Receptor Antagonists - D. Hamprecht (I) .

Development of Chemokine Receptor Antagonists R. Leurs (NL) Chemokine Receptor Antagonists: What Next? - R. Horuk (USA); CCR5 Antagonists for the Treatment of HIV - D. Pryde (UK); Small Molecule Antagonists of the CXCR2 Chemokine Receptor - J. Wijkmans (NL); Development of Chemokine Receptor Modulators - M. Allegretti (I)

alpha-Adrenoceptors: What Progress Has Been Made? R. A. Glennon (USA) Molecular Pharmacology of alpha2-Adrenoceptor Subtypes - M. Scheinin (FI); alpha-2-Adrenoceptor Agents in the Modulation of Pain - M. Dukat (USA).

Summing up D. J. Triggle (USA).

RegistrationRegistration requests should be made on-line. All participants will receive acknowledgment of registration not later than July 31, 2007. The registration fee has been set for active participants and accompanying persons, respectively, at € 950 and € 450 before May 31, and at € 1150 and € 550 after May 31, 2007. Participants from academic institutions have the right to a € 150 discount on their enrollment fee. Members of the Italian Chemical Society have the right to an additional € 50 discount. The registration fee entitles participants to take part in conferences, social events, and all meals.The registration fee for accompanying persons entitles them to participate in social events, and all meals.The timetable of the social events will be communicated to the participants together with the final scientific program.Due to restrictions of space, it may be necessary to limit the number of those attending. Early registration is advised.

All payments, net of bank expenses, have to be made: - by bank transfer to the Banca delle Marche, 62032 Camerino, BBAN: N 06055 68830 000000008287in favor of “Receptor Chemistry - Dipartimento di Scienze Chimiche”, or- by banker’s draft in favor of “Receptor Chemistry - Dipartimento di Scienze Chimiche”.

RefundsUpon cancellation before August 1, 2007, 80% of the fee will be refunded. After August 1, no refund will be possible.

Scientific Program

Deorphanized Receptors R. Ciccocioppo (I) Orphan GPCRs and the Search for New Neurotransmitters and Their Functions - O. Civelli (USA); Structure Activity Studies on Neuropeptide S - G. Calò (I).

WNT PathwayM. Giannella (I)High Throughput Virtual Screening in Modern Drug Discovery – A. Padova (I); Hedgehog Receptors – Modeling Based Approaches for Cancer Research - G. Robertson (I); The Wnt Pathway – Phenotype Screening Approaches to the Treatment of Neurodegenerative Diseases – G. Gaviraghi (I).

Nuclear Receptors L Mosti (I)Modulators for the Farnesoid X Receptor (FXR): from Bench to Therapeutic Exploitations - R. Pellicciari (I); Identification and Characterization of Highly Potent Activators of the Nurr1 (NR4A2) Pathway - a Novel Approach to Treat Parkinson Disease? - S. Hintermann (CH); Blockade of PPAR-Gamma - W. J. Hoekstra (USA); Potent and Balanced Dual PPAR Alpha/Gamma Agonists: Combining Antidiabetic and Hypolipidemic Activity - U. M. Grether (CH).

New Aspects on GPCRs G. Marucci (I)Molecular Mechanisms of Agonist-Induced Activation of GPCRs - L. Pardo (E); Molecular Basis of GPCR Function - J. Wess (USA); Allosterism at GPCRs: from Ligands to Drugs? - N. Birdsall (UK); Molecular Mechanisms of Inverse Agonism at GPCRs - T. Costa (I); Mechanisms of Agonist Efficacy at GPCRs - P. G. Strange (UK); Probing Structural Rearrangement within Receptor/G Protein Complexes Using BRET Technology - C. Gales (F).

NoteThe Medicinal Chemistry Division has awarded 2 free grants (enrollment fee, and lodging in the University Residences) for Ph.D. research students in Medicinal Chemistry who are members of the Italian Chemical Society. Those interested should send to the Secretariat not later than April 30, 2007 a CV giving their graduation marks, the title of their dissertation, and current field of research. In the event that the requests to participate should exceed this number, then an integrative fee will have to be paid.

Advised Hotels/Country Houses

Camerino

Albergo Ristorante I DUCHI ***Via V. Favorino, 7262032 CamerinoTel: +39-0737-630440 Fax: +39-0737-630455http://www.hoteliduchi.it

Nearby Camerino

B&B COLLE RIDENTELoc. Colle Ridente, 2 Montagnano62032 CamerinoTel: +39-0737-637000 Mobile: +39-339-4818118http://www.colleridente.it/camerino.htm

Agriturismo FATTORIA DI CIGNANO Loc. Cignano n.562032 CamerinoTel: +39-0737-633595

Albergo Borgo di Lanciano****Loc. Lanciano, 562022 CastelraimondoTel: +39-0737-642844Fax: +39-0737-642845

Albergo Al Borgo Antico***Fraz. Morro p.zza Macallè, 362032 CamerinoTel: +39-0737- 637597 Mobile: 335-7248806

Albergo Il Cavaliere ***Via Mariani 33-35 Loc. Polverina62032 CamerinoTel: +39-0737- 46128 Fax: +39-0737-46129

Albergo Roma **P.zza Garibaldi, 662032 CamerinoTel: +39-0737-630125 Fax: +39-0737-632592

Albergo del Sole **Via Mariani, 59Loc. Polverina62032 CamerinoTel: +39-0737- 46115 Fax: +39-0737-46167

Hotel Massi***Via A. Merloni62024 MatelicaTel. +39 073784781 Fax +39 073785981

Hotel Bellavista***Via S. Anna, 11 62022 Castelraimondo Tel. +39 0737640717 Fax +39 0737642110

Other Camerino Hotels/Country Houses

Motel Carnevali***Bivio Maddalena S.S. 77 62034 MucciaTel. +39 0737646138 Fax +39 0737646428

Albergo Il Cacciatore***Via Spinabello, 1362034 MucciaTel. +39 0737646121Fax. +39 0737647002

Hotel della Loggia***P.za E. Mattei, 1262024 MatelicaTel. +39 073785830 Fax +39 0737787239

Hotel Panorama*** via Del Colle, 5Loc. Crispiero,62022 CastelraimondoTel: +39-0737-642642 Agriturismo La CavallinaFraz. Polverina Via Mariani, 1362032 CamerinoTel: +39-0737-46173 Fax: +39-0737-464500

Agriturismo Le CortineVia D’Accorso, 75 Loc. S. Paolo62032 CamerinoTel: 0737-616840 Mobile: +39-333-2237294

Agriturismo DragoncelloLoc. Servola, 562032 CamerinoTel: 0737-637184 Mobile: +39-333-1773059

Agriturismo Le Arcate diS. AngeloLoc. Morrone62032 CamerinoTel: +39-339-8852761

Casa Per Vacanze Villa Maria Via G. Di Giovanni, 4162032 CamerinoTel: +39-335-5868697

Casa Per Vacanze Largo ValentiniL.go Valentini, 462032 CamerinoTel & Fax: +39-0737-630232

Casa Per Vacanze Ja. Le. Via Conti Di Borgo, 8362032 CamerinoTel: +39-0737-630287 Fax: +39-0737-46157

Casa Per Vacanze I GirasoliLoc. S. Marcello, 2462032 CamerinoTel: +39-0737-632740 Mobile: +39-335-7503752

Country House Pappafo’Loc. Montagnano, 9862032 CamerinoTel: +39-0737-630794 Fax: +39-0737-631336

B&B Poggio MariaLoc. Agnano, 162032 CamerinoTel: +39-0737-644318 Mobile: +39-338-8616850

B&B Fabris BrunaLoc. Rocca Varano62032 CamerinoTel: +39-0737-630488

B&B Palazzetto GiochiLoc. Casale Di Morro62032 CamerinoTel: +39-0733-35929 Mobile: +39-347-3336460

B&B Marggraf Mary C.Loc. Costa S. Severo, 862032 CamerinoTel: +39-0737-42302 Fax: +39-0737-631114

B&B CaselungheLoc. Caselunghe, 262032 CamerinoTel: +39-0737-632840 Mobile: +39-347-1957021

B&B Poggio PaganicoLoc. Paganico62032 CamerinoTel: +39-0737-644489 Mobile: +39-340-3188476

B&B Il Mandorlo in FioreVia Le Mosse, 2562032 CamerinoTel: +39-0737-633048 Mobile: +39-339-6214347

B&B CamerteFraz. Mergnano S. Savino Via Berta, 562032 CamerinoTel: +39-06-7180753 Mobile: +39-328-8419245

B&B Torre TenosaLoc. Santa Lucia, 1362032 CamerinoTel: +39-0737-633500 Mobile: +39-334-1846842

B&B PalombaLoc. Palombare, 262032 CamerinoTel: +39-0737-644121

The use of one own’s car is advised