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A1CThen

SlowLab results and patient follow-up takes days.

ComplicatedIn-office machines require maintenance, calibration and staff training.

CumbersomeLab samples need to be labeled, tracked and may need refrigeration.

LaggingA1c testing is on the rise. Status quo solutions won’t do.

AccurateLab accuracy determined by independent NGSP certification protocol.

FastOn-the-spot results in 5 minutes for better doctor/patient communication.

SimpleMinimal staff training required. Factory-calibrated to NGSP standard.

EfficientAllows testing in every exam room. No samples to track or refrigerate.

LeadingNew technology to meet the rising demand for A1c testing.

AccurateAccuracy determined by same NGSP protocol used by labs.

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» NGSP certified accuracy

» CLIA waived

» Every meter is factory calibrated meaning no daily controls and no maintenance

» No refrigeration if used within four months

» Only 5 μL of blood from a fingertip is needed

» Results in 5 minutes for immediate feedback

» Run in multiple exam rooms

» Portable, handheld device

» Available in 10 and 20 count test kits

» Simple sampling procedure

SpecificationsBayer A1CNow+

For more information,

visit www.A1CNOW.com or call us at:

Tech Support 1-877-212-4968

Customer Support 1-800-248-2637

Fast. Easy. Accurate.

Visit www.A1CNOW.com

Accurate Results

13

15

11

9

7

5

3

n = 80

%HbA1C NGSP Tosoh

%H

bA1C

A1C

Now

+

Bia

s (A

1C

No

w+

- N

GSP

)

y = 0.9851x + 0.2917r = 0.987

153 5 7 9 11 13

2

3

1

0

-1

-2

-3

n = 80

%HbA1c NGSP Tosoh

153 5 7 9 11 13

A1CNow+ vs. NGSP Tosoh Total Error

13

15

11

9

7

5

3

n = 80

%HbA1C NGSP Tosoh

%H

bA1C

A1C

Now

+

Bia

s (A

1C

No

w+

- N

GSP

)

y = 0.9851x + 0.2917r = 0.987

153 5 7 9 11 13

2

3

1

0

-1

-2

-3

n = 80

%HbA1c NGSP Tosoh

153 5 7 9 11 13

A1CNow+ vs. NGSP Tosoh Total Error

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» Bayer’s A1CNow+ is annually certified by the National Glycohemoglobin Standardization Program (NGSP).

» The purpose of the NGSP is to standardize glycated

hemoglobin test results so that A1c results are comparable

to those reported in the Diabetes Control and Complications

Trial (DCCT) where relationships to mean blood glucose and

risk for vascular complications have been established.1

» In order to achieve NGSP certification, an A1c testing

method must successfully complete rigorous testing

requirements annually.1

» A key component of the program is the Reference

Laboratory Network. The network interacts with

manufacturers of glycohemoglobin methods to assist them

first in standardizing their methods and then in providing

comparison data for certification of traceability to the DCCT.

» A1c test methods are awarded a ‘certificate of traceability

to the DCCT reference method’ if they pass rigorous

accuracy testing criteria.1

NGSP Certification

As you use A1CNow+, you may have questions about the level of performance to expect. The following information will help you answer those questions and interpret differences you may see between results when using A1CNow+ and other A1c methods.

» Total Error Total error is a concept that combines both accuracy and precision. Total error is used by the NGSP to describe a test’s accuracy, and it is closely related to the probable error for a single laboratory result. A NGSP certification is granted when 95% of the results from a testing method are within ±0.85% of the reference (true) value.2

» Difference Between Methods There will always be differences between multiple test results due to normal variation, time between tests and differences between methods. In fact, duplicate test results from the same patient will rarely match even when the test is performed by the same method at the same time. Within the NGSP’s “95% confidence interval of differences” of ±0.85%, differences can sometimes appear greater because one result could be slightly higher and the other could be slightly lower than the reference (true) value.2

» Sources of Variation There are a variety of methods used to measure A1c and all methods are susceptible to interference from variant hemoglobins such as Hb S and Hb C. Pathologic conditions that affect red cell half-life can also affect A1c results regardless of the testing method. These conditions may include iron deficiency anemia (pro-longed red cell survival, leading to increased A1c results), chronic blood loss, or chronic renal failure (shortened red cell survival, leading to lowered A1c results).

Tech support 1-877-212-4968 Customer support 1-800-248-2637

1 www.ngsp.org/prog/index.html 2 The 95% confidence interval of the differences is defined by NGSP to be the average difference +/- 1.96 x the standard deviation of the differences under a special protocol that defines the distribution and number of samples. See www.ngsp.org/prog/protocol/prot.html for details.

DIABETES CARE: Brand Guidelines

For correct logo usage, refer to instructions oncorporate logo guidelines at www. corporatedesign.bayerhealthcare.com

Accurate Results

DIABETES CARE: Brand Guidelines

For correct logo usage, refer to instructions oncorporate logo guidelines at www. corporatedesign.bayerhealthcare.com

© 2008 Bayer HealthCare LLC. Bayer, the Bayer Cross and A1CNow+ are registered trademarks of Bayer.

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A1CThen

1 Miller CD et al., Rapid A1C availability improves clinical decision-making in an urban primary care clinic. Diabetes Care 2003; 26:1158-1163. 2 Cagliero E et al., Immediate feedback of HbA1C levels improves glycemic control in type 1 and insulin-treated type 2 diabetic patients. Diabetes Care 1999; 22: 1785-1789.

Fast. Easy. Accurate.

More Efficient Than The Lab.

9. Chart filed.

1. Finger stick or venipuncture.

2. Results in 5 minutes.

3. With immediate results, physicians are twice as likely to modify treatment on the spot. 1

4. Chart filed.

Patients who get immediate feedback may lower their A1C by up to 1%.1,2

See for yourself.

1. Venous sample drawn.

3. Lab work done.

2. Sent to lab.

4. Clinic contacted.

5. Patient chart reviewed.

7. Patient contacted. May require multiple calls.

6. Results reviewed.

8. Intervention documented.

Visit www.A1CNOW.com or call Customer Support 1-877-212-4968