Prof Carine SmithCurriculum Vitae

Updated November 2013

1. BIOGRAPHICAL SKETCH

1.1 GENERAL INFORMATIONSurname SmithFirst names CarineCitizenship South African Title Prof Female X Male

Organisation Stellenbosch UniversityFaculty Science Position Associate ProfessorTelephone number 021-8084388 Direct telefax number 021-8083145E-mail address csmith@sun.ac.za

1.2 ACADEMIC QUALIFICATIONS OBTAINEDDegree/Diploma

Field of study Higher education institution Year

National Diploma

National Higher Diploma

BTech

MPhil

PhD

Medical Laboratory Technology (cum laude)

Medical LaboratoryTechnology (3 distinctions)

Biomedical Technology (cum laude)

Exercise Science

Physiological Sciences

Cape Technikon

Cape Technikon

Cape Technikon

Stellenbosch University

Stellenbosch University

1993

1994

1996

1999

2004

1.3 WORK EXPERIENCE TO DATEName of employer Capacity and/or type of work Period

Provincial Administration of Western Medical Technologist Nov 1991 – Feb 1998

Cape – Tygerberg HospitalStellenbosch University Technical and Financial Officer Mar 1998 – Jul 2007Stellenbosch University Lecturer Aug 2007 – Dec 2009Stellenbosch University Senior Lecturer Jan 2010 – Dec 2011Stellenbosch University Associate Professor Since Jan 2012

2. TEACHING ACTIVITIES

2.1 COURSES PRESENTEDCourse Level Self Developed

Blood 114 First year yes

Haematology 214 Second year yes

Physiology 214 – Digestive physiology I, II & III (practicals) Second year yes

Physiology 214 – Practical hematology (practical) Second year yes

Physiology 244 – Presentation skills I,II & III (practicals) Second year partially

Immunology 344 Third year yes

The Brain 314 Third year yes

Clinical Haematology 324 Third year yes

Physiology 314 – Anatomy & histology (practical module) Third year yes

Physiology 314 - Hematology Third year yes

Physiology 314 – Metabolic syndrome I & II (practicals) Third year partially

Physiology 314 – Spirometry (practical) Third year no

Physiology 314 – Basal metabolic rate (practical) Third year no

Physiology 344 – Exercise and metabolism (practical) Third year yes

Physiology 344 – Immunology (WebCT-based practical) Third year yes

Physiology 314 and 344 - Histology Third year no

Physiology 344 – Immunology (wet practical) Third year yes

Physiology 778 – Immunological techniques BSc Hons yes

Physiology 778 – Clinical immunology (tutorial) BSc Hons yes

Advanced Immunology 778 BSc Hons yes

Stress Physiology 778 BSc Hons yes

Exercise Immunology, endocrinology and hematology 887 Mphil yes

Laboratory safety and ethical aspects of human testing Mphil yes

3. OTHER TEACHING OUTPUTS

3.1 Health and Safety workshop presented to new postgraduate students, Faculty of Science, Stellenbosch

2

University (safe handling of biological samples, biological spills) (2010)

3.2 Developed course content for course on “HIV in sport” (physiological perspective), used in community

outreach initiatives by SUSPI (2010)

3.3 Invited to lecture on Honours course at other departments at Stellenbosch University:

Dept of Sport Science

4. RESEARCH ACTIVITIES

4.1 FORMER SUPERVISION OR CO-SUPERVISION (Completed)Name of Student Degree / Title of dissertation /

thesis and dateSupervisor Co-supervisor Duration of

studyHonorsChambers J-M BScHons (Physiol Sci) / The effect of

a competitive season on selected parameters of the immune system of professional soccer players / 2004

C Smith KH Myburgh 1 yr

Doubell P BMedSci(Hons) / The effect of glutamine supplementation of PBMC IL-6 secretion after acute high-intensity exercise / 2004

C Smith P Bouic 1 yr

Visser JAK BScHons (Biochem) / Modulation of glucocorticoid action by interleukin-6 in liver cells / 2007

Dr A Louw C Smith 1 yr

Qwemesha G BScHons (Physiol Sci) / The role of IL-6 in C2C12 skeletal muscle myoblast cell proliferation / 2007

C Smith KH Myburgh, R Smith

1 yr

Eiman S BScHons (Physiol Sci) / Long term effects of TB on body composition changes in HIV-patients on antiretroviral therapy for longer than twelve months. / 2007

KH Myburgh C Smith 1 yr

Van der Merwe AH BScHons (Physiol Sci) / Apoptosis and atrophy of skeletal muscle in response to intermittent psychological stress. / 2007

KH Myburgh C Smith, A-M Engelbrecht

1 yr

Fouche JP BScHons (Physiol Sci) / Mitogen-activated protein kinase and inflammatory pathways involved in psychological stress-induced muscle atrophy in rat skeletal muscle and effects of exercise on recovery / 2007

KH Myburgh C Smith, A-M Engelbrecht

1 yr

Viljoen M BScHons (Physiol Sci) / Psychological, immunological and endocrinological aspects of the stress response to physical and psychological stressors. / 2007

C Smith KH Myburgh 1 yr

Uys M

BScHons (Physiol Sci) / Cross-sectional analysis of selected health

KH Myburgh C Smith 1 yr

3

parameters in a semi-rural population / 2008

Janse van Vuuren M BScHons (Physiol Sci) / The role of IL-6 in the acute stress response / 2008

C Smith 1 yr

Jordaan A BScHons (Physiol Sci) / Metabolic syndrome risk profile in young vs. older populations in Stellenbosch / 2009

MF Essop C Smith 1 yr

De Wet J BScHons (Physiol Sci) / Inflammatory response to contusion injury: effect of post-injury antioxidant treatment / 2009

C Smith 1 yr

Pretorius GM BScHons (Physiol Sci) / Immune-glucocorti-coid interaction in response to stress: effect of treatment with grape seed extract / 2009

C Smith 1 yr

Coetzer M BScHons (Physiol Sci) / The effects of Sutherlandia frutescens on the ACTH and non-ACTH mediated regulation pathways during acute stress / 2010

C Smith 1 yr

Van Rensburg L BScHons (Physiol Sci) / Lifestyle and inflammatory profiles of an older Stellenbosch campus population in association with the prevalence of risk factors associated with the metabolic syndrome / 2010

C Smith 1 yr

Van der Walt M BScHons (Physiol Sci) / Longitudinal assessment of overtraining in rugby players 2011

C Smith KH Myburgh 1 yr

Ngonyi R BScHons (Physiol Sci) / Effects of housing conditions on immune status in research unit animals 2011

C Smith RM Smith 1 yr

Meissner B BScHons (Psychology) / Depression, anxiety and the metabolic syndrome in South African students: is there a link? 2011

A Kagee C Smith 1 yr

Roos M BScHons(Physiol Sci) Effects of Rooibos supplementation on central IL-6 secretion in response to stress 2012

C Smith 1 yr

McGeachie L BScHons (Physiol Sci) African drumming: just music or also endurance exercise? 2012

C Smith 1 yr

Wurz J Effects of PCO supplementation on inflammatory response to muscle injury

C Smith KH Myburgh 2013

MSc and MphilWilliams AW Mphil (Exercise Science)/ The effect

of a strenuous 5-week provincial cricket schedule on physical performance capacity and

C Smith KH Myburgh 2 yr

4

immunological function of professional cricketers/ 2001

Neethling IG MSc (Physiological Sciences) / The efficacy of the Sutherlandia herb and/or resistance exercise to alleviate the effects of a mild intermittent stress procedure/ 2005

KH Myburgh C Smith 3 yr

De Bruto PC Mphil (Exercise Scienc) / Monitoring of selected physiological parameters and quality of life in HIV-positive subjects over a 6-month period, in comparison with a control group of HIV-negative controls/ 2006

KH Myburgh C Smith 2 yr

Kruger MJ MSc (Physiological Sciences) / Antioxidant (OxiprovinTM) supplementation and muscle recovery from contusion injury – an in vivo study/ 2007

C Smith KH MyburghRM Smith

2 yr

Viljoen M MSc (Physiological Sciences) / Effect of blocking IL-6 on the response to short-term intermittent stress in rats / 2009

C Smith 2 yr

Moyen M MPhil (Exercise Science) / Effects of ARV treatment on body composition in a HIV-positive female population / 2009

KH Myburgh C Smith 2 yr

Visser JAK MSc (Biochemistry) / Effect of modulators of inflammation on hepatic acute phase proteins and metabolic enzymes/ 2009

A Louw C Smith 2 yr

Wolmarans WJ MSc (Animal Sciences) / The effect of transport on live weight loss, meat quality and blood haematology in slaughter ostriches / 2010

LC Hoffman C Smith T Brand

2 yr

Janse van Vuuren M MSc (Physiological Sciences) / Hypothalamic-pituitary-adrenal axis vs. the sympatho-adrenal medullary system in the acute response to psychological stress / 2010

C Smith 2 yr

Viljoen JT MPhil (Exercise Science) / Short-term effects of grape seed extract supplementation in a model of plyometric exercise-induced muscle damage / 2010

KH Myburgh C Smith 2 yr

Phiri TM MSc (Physiol Sci) / Predictive value of gene mutations as a diagnostic tool for ART resistance in a Zambian population / 2012

C Smith RM Smith 2 yr

Maine C MSc (Human Nutrition) / The relationship between dietary intake, body composition and incidence of upper respiratory tract infections in triathletes during training and competition for the Ironman / 2012

S Potgieter C Smith 3 yr

Delport C MPhil (Exercise Science) / Mechanisms for decreased

KH Myburgh C Smith 2 yr

5

neutrophil infiltration after plyometric exercise-induced muscle damage and grape seed extract supplementation/ 2012

Robyn A Mphil (Exercise Science) / Monitoring overtraining in rugby players over the course of a season / 2013

C Smith 5 yr (part-time)

PhDKruger MJ PhD (Physiol Sci) / Immune and

satellite cells: important role players in muscle recovery after injury / 2010

C Smith KH Myburgh 3 yr

Brand AN PhD (Microbiology) / In vivo monitoring of the antimicrobial activity of nisin F against systemic Staphylococcus aureus infections / 2012

LMT Dicks C Smith 3 yr

Potgieter S PhD (Human Nutrition) / The effect of caffeine supplementation on Olympic distance triathletes and triathlon performance in the Western Cape region / 2012

C Smith H WrightL Warnich

3 yr

4.2 CURRENT POST-GRADUATE STUDENTSName of Student Degree / Title of dissertation /

thesis and dateSupervisor Co-supervisor Year of

registrationHonorsTo be announcedMScAfrica L MSc (Physiol Sci) / Preventative

effects of two natural plant extracts on HIV-related neurodegeneration

C Smith 2012

PhDSchloms L MSc (Biochemistry) / Effect of short-

term oral Rooibos supplementation on the acute response to stress in rats

A Swart C Smith 2010 (upgraded from MSc end of 2011)

Viljoen M PhD (Physiol Sci) / Correlations in adolescents between anxiety, childhood trauma, resilience and physiological determinants of health, both centrally and peripherally

C Smith S Seedat 2010

Hill (George) C PhD (Medical Physiology) / The regenerative and anti-inflammatory capability of Prosopis gladulosa

B Huisamen C SmithD Dietrich

2010

6. RESEARCH OUTPUTS

6.1Publications in peer-reviewed or refereed SCI journals

6

1. Strauss JA de W, Myburgh KH, Kruger A, Smith C, Robson PJ. Pre-exercise glutamine

supplementation could prevent decreases in postexercise serum glutamine following a single bout of

intensive exercise. South African Journal of Sports Medicine 8(2): 12 – 16, 2001.

2. Pool EJ, Robson PJ, Smith C, Van Wyk JH, Myburgh KH. In vitro interleukin-6 release in whole blood

cultures in samples taken at rest from triathletes and professional rugby players. European Journal of

Applied Physiology and Occupational Physiology 87:233 –237, 2002.

3. Williams AW, Myburgh KH, Smith C*. The effect of a professional cricket match schedule on selected

immune parameters. South African Journal of Sports Medicine 16(2): 22 – 27, 2004.

4. Smith C*, Myburgh KH. Treatment with Sutherlandia frutescens subs. microphylla alters the

corticosterone response to chronic intermittent immobilisation stress in rats. South African Journal of

Science 100: 229–232, 2004.

5. Prevoo D, Smith C, Swart P, and Swart AC. The effect of Sutherlandia frutescens on steroidogenesis:

confirming indigenous wisdom. Endocrine Research 30(4): 745-751, 2004.

6. Smith C*, Myburgh KH. Assessment of endocrine status in athletes: new twists to the tale. South

African Journal of Sports Medicine 17(3): 19-30, 2005. (review)

7. Smith C*, Myburgh KH. Are the relationships between early activation of lymphocytes and cortisol and

testosterone influenced by intensified cycling training in men? Applied Physiology, Nutrition and

Metabolism 31(3):226-234, 2006. (impact factor 1.567)

8. Smith C*, PJ Erasmus, Myburgh KH. Effect of Dexamethasone injection on the endocrine and immune

responses to unilateral knee-replacement surgery. Journal of International Medical Research 34(6): 603

– 611, 2006. (impact factor 0.665)

9. Smith C*, Myburgh KH. Mountain-bike racing: the influence of glycogen status and glutamine

supplementation on markers of the general stress and immune responses. South African Journal of

Sports Medicine 18(4):67 – 73, 2006.

10. Smith C*, NW Wilson, A Louw, KH Myburgh. Illuminating the interrelated immune and endocrine

responses to chronic mild intermittent stress by in vivo blocking of IL-6. American Journal of Physiology:

Regulatory Integrative and Comparative Physiology 292:1439 – 1447, 2007 (impact factor 3.661)

11. Engelbrecht A-M, Mattheyse M, Ellis B, Loos B, Thomas M, Smith R, Peters S, Smith C, Myburgh K.

Proanthocyanidin from grape seeds inactivates the PI3-Kinase/PKB pathway and induces apoptosis in

a colon cancer cell line. Cancer Letters 258(1):144 – 153, 2007. (impact factor 3.398)

12. Smith C*, Kruger M, Smith RM, Myburgh KH. The inflammatory response to skeletal muscle injury:

illuminating complexities. Sports Medicine 38(11): 947 – 969, 2008. (review) (impact factor 3.619)

13. Smith C*, Essop MF. Gender differences in metabolic risk factor prevalence in a South African student

population. Cardiovascular Journal of Africa 20(3):178 – 182, 2009.

14. Engelbrecht AM, Smith C, Neethling IG, Thomas M, Ellis B, Matthysen M, Myburgh KH. Daily brief

restraint stress alters signaling pathways and induces atrophy and apoptosis in rat skeletal muscle.

STRESS, The International Journal on the Biology of Stress 13(2): 132 – 141, 2010. (impact factor

2.531)

7

15. Visser JAK, Smith C, Louw A. Interplay of the inflammatory and stress systems in a hepatic cell line:

interactions between glucocorticoid receptor agonists and interleukin-6. Endocrinology 15(11): 5279-93,

2010 (impact factor 4.752)

16. Smith C*. The effects of Sceletium tortuosum in an in vivo model of psychological stress. Journal of

Ethnopharmacology 133: 31-36, 2011 (impact factor 2.322)

17. Kruger MJ, Smith C*. Post-contusion polyphenol treatment alters inflammation and muscle

regeneration. Medicine and Science in Sports and Exercise 44(5): 872-880, 2012 (impact factor 4.431)

18. Myburgh KH, Kruger MJ, Smith C*. Accelerated skeletal muscle recovery after in vivo polyphenol

administration. Journal of Nutritional Biochemistry 23: 1072-1079, 2012 (impact factor 4.8).

19. Botha M, Botes M, Loos B, Smith C, Dicks LMT. Lactobacillus equigenerosi Strain Le1 invades equine

epithelial cells. Applied and Environmental Microbiology 78(12): 4248-4255, 2012.(impact factor 3.778)

20. Hoffman LC, Wolmarans WJ, Smith C, Brand TS. Effect of transportation on ostrich (Struthio camelus)

weight loss and meat quality. Animal Production Science 52: 1153-1162, 2012. (impact factor 0.986)

21. Heunis TDJ, Smith C, Dicks LMT. Evaluation of a nisin-eluting nanofiber scaffold to treat

Staphylococcus aureus-induced skin infections in mice. Antimicrobial Agents and Chemotherapy 57(8):

3928 – 3935, 2013. (impact factor 4.565)

22. Brand AM, Smith C, Dicks LMT. The effects of continuous in vivo administration of nisin on

Staphylococcus aureus infection and immune response in mice. Probiotics and antimicrobial proteins

(in press 2013, DOI 10.1007/s12602-013-9141-3)

23. Kruger MJ, Myburgh KH, Smith C*. Contusion injury with chronic in vivo polyphenol supplementation:

leukocyte responses. Medicine and Science in Sports and Exercise (accepted 2013, epub 16 July 2013,

PMID: 23863619) (impact factor 4.431)

24. Schloms L, Swart AC, Smith C, Storbeck K-H, Marnewick J, Swart P. Rooibos influences glucocorticoid

and steroid ratios in vivo and in vitro: a natural approach in the management of stress and metabolic

disorders? Molecular Nutrition and Food Research (accepted 2013, epub 11 Sept 2013, DOI:

10.1002/mnfr.201300463; PMID: 24022885) (impact factor 4.301)

25. Smith C*, Janse van Vuuren M. Central and peripheral effects of Sutherlandia frutescens on the

response to acute psychological stress. Experimental Biology and Medicine (accepted 2013) (impact

factor 2.8)

26. Smith C*, Viljoen JT, McGeachie L. African drumming: a holistic approach to reducing stress and

improving cardiovascular health. Journal of Cardiovascular Medicine (accepted 2013)(impact 1.51)

27. Smith C*, Essop MF. Influence of lifestyle choices on metabolic risks results in distinct gender- and age-

differences. International Journal of Clinical and Experimental Physiology. (accepted 2013)

6.2 Book chapters

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1. Smith C. Using rodent models to simulate stress of physiologically relevant severity: when, why and

how (Chapter 10, pp 211-230). IN: Glucocorticoids: new recognition of our familiar friend. Editor X.

Qian, InTech, Rijeka, Croatia, 2012 (ISBN 978-953-51-0872-6)

6.3Technical reports

1. Research report prepared for Brenn-o-kem on results of contract research. “Chronic Oxiprovin

treatment facilitates quicker recovery from skeletal muscle contusion injury in rats“ 2007

2. Research report prepared for HL Hall & Sons on results of contract research. “Effects of Halex

treatment on the stress response to intermittent immobilization stress in rats” 2008

3. Research report prepared for Brenn-o-kem on results of contract research. “Acute Oxiprovin treatment

facilitates quicker recovery from skeletal muscle contusion injury in rats“ 2011

4. Research report prepared for Brenn-o-kem on results of contract research. “Oxiprovin treatment limits

inflammation and alters monocyte phenotype expression“ 2013

5. Research report prepared for Verve Dynamics on results of contract research. “Effects of Sceletium

tortuosum on steroidogenesis”, 2013

6.4 Dissemination of research results in recent lay publications and media coverage

1. “African drumming: just music, or also endurance exercise.” This project was a world first for research in the field of drumming, and was covered extensively by the media in July 2012:

You tube: https://www.youtube.com/watch?v=L5zyyodudKI Die Burger website: http://www.dieburger.com/Suid-Afrika/Nuus/VIDEO-Tromslae-is-

oefening-20120719 Health24 5 July 2012 http://www.health24.com/news/Fitness/1-911,75412.asp Volksblad 17 July 2012 Die Burger 17 July 2012 I was also interviewed for a news bulletin first broadcasted on KykNet’s e-news on 16 July 2012

7. OTHER SCHOLARLY RESEARCH-BASED CONTRIBUTIONS

7.1 Participation in conferences, workshops and short courses

7.1.1 International (Oral presentations)

1. Myburgh KH, Smith C. Does hypoxia during recovery from fatiguing exercise affect plasma lactate

decay curves? 12th International Hypoxia Symposium, Jasper Park, Alberta, Canada, 2001

2. Myburgh KH, Du Toit J, Smith C. Changes in performance and resting cortisol in response to 8 weeks

of high intensity training. 50th Annual Meeting of the American College of Sports Medicine, Saint Louis,

Saint Louis, USA, 2002.

9

3. Myburgh KH, Neethling IG, Smith C. Early increases in 20s Proteasome activity in fast and slow twitch

muscle of rats exposed to moderate psychological stress. “New Directions in Biology of Disease of

Skeletal Muscle” conference, Dallas, Texas, USA, 2006.

4. Myburgh KH, Neethling IG, Smith C. Moderate intermittent physiological stress increases rat muscle

20s proteasome activity, but exercise can induce recovery. 54th Annual Meeting of the American

College of Sports Medicine, New Orleans, Louisiana, 2007.

5. Kruger MJ, Smith C, Smith RM, Myburgh KH. Antioxidant supplementation enhances muscle recovery

from contusion injury in rats. New Directions in Biology & Disease of Skeletal Muscle: 3rd Conference,

New Orleans, USA, April, 2008.

6. Myburgh KH, Qwemesha GP, Smith C, Smith RM. Integrative approach to determining the effects of the

cytokine, Interleukin (IL)-6, on skeletal muscle cells in vitro. 56th Annual Meeting of the American

College of Sports Medicine, 2009

7. Swart AC, Schloms L, Smith C, Storbeck K-H, Swart P. Rooibos: a functional food in the management

of metabolic disorders? Molecular Medicine Conference, Mahidol University Bangkok Thailand,

December 2012

8. Smith C. Treatment of acute muscle damage: a view from immune cells. 2013 ACSM Annual Meeting

and World Congress on Exercise is Medicine, Indianapolis, Indiana, 2013. (Invited speaker at “Current

issue” symposium)

9. Swart AC, Schloms L, Smith C. Rooibos: a natural approach in the management of stress and

metabolic disorders. XXth congress of AETFAT, 13-17 January 2014, Stellenbosch, South Africa.

7.1.2 International (Poster presentations)

1. Myburgh KH, Smith C, T Kohn. Responses of African and Caucasian runners to hypoxia. American

Physiology Society: Congress for Integrative Biology of Exercise, Portland, Maine, USA, 2000.

2. Myburgh KH, Smith C. Does hypoxia during recovery from fatiguing exercise affect plasma lactate

decay curves? 12th International Hypoxia Symposium. Jasper, Canada, 2001.

3. Swart AC, Prevoo D, Smith C, Swart P. The influence of the indigenous shrub Sutherlandia Frutescens

(Cancer bush) on adrenal steroidogenesis. 11th Adrenal Cortex Conference. New Orleans, Louisiana,

USA, 2004.

4. Smith C, Myburgh KH. Mountain-bike racing: Glycogen status and glutamine supplementation effects

on white blood cells and endocrine responses. 52nd Annual meeting of the American College of Sports

Medicine. Nashville, Tennessee, USA, 2005.

5. Smith C, Wilson NW, Louw A, Myburgh KH. The importance of IL-6 in the response to short-term

intermittent immobilisation stress in rats, both in circulation and downstream: illuminated using an IL-6

antibody. 11th Annual Congress of the European College for Sport Science, Lausanne, Switzerland,

2006.

10

6. Engelbrecht, A-M, Smith, C, Brooks, N & Myburgh, KH. Chronically elevated levels of phosphorylated

p38 MAPK and ERK 44 in response to psychological stress in rodents. Life Science Conference,

Glasgow, UK, July 2007

7. Kruger MJ, Smith C, Smith RM, Myburgh KH. Antioxidant supplementation enhances muscle recovery

from contusion injury in rats. American Physiological Society inter-society meeting: Integrative Biology

of Exercise, Hilton Head, South Carolina, September 2008.

8. Smith C, Pretorius GM, Kruger MJ. Acute post-injury supplementation with grape seed extract

modulates the inflammatory response in favor of skeletal muscle recovery. 15 th Annual Congress of the

European College of Sport Science, Antalya, Turkey, 2010

9. Schloms L, Storbeck K-H, Smith C, Marnewick JL, Swart P, Swart AC. The influence of Aspalathus

linearis flavonoids on glucocorticoid biosynthesis. 36th FEBS Congress: Biochemistry for tomorrow’s

medicine. Torino, Italy, June 2011

10. Smith C, Kruger MJ, Myburgh KH. Inflammation-modulating effects of proanthocyanidolic oligomer

supplementation in a model of contusion injury. Annual conference of the International Society for

Exercise Immunology, Oxford, UK, July 2011

11. Brand AM, Smith C, Smith RM, Dicks LMT. Immune response elicited in mice by nisin F administered

intraperitoneally. 10th symposium on lactic acid bacteria. Egmond aan Zee, Netherlands, August 2011

12. Botha M, Botes M, Smith C, Dicks LMT. Transition of probiotic lactic acid bacteria through the horse

intestine and physiological changes recorded. 10th symposium on lactic acid bacteria. Egmond aan Zee,

Netherlands, Aug 2011

7.1.3 National (Oral presentations)

1. Smith C. Tennis: Serving, receiving and training. 8 th bi-annual congress of the South African Sport

Medicine Association, Midrand, Johannesburg, 6 – 8 September 1999

2. Strauss JA De W, Myburgh KH, Kruger A, Smith C. Pre-exercise glutamine supplementation can

prevent post-exercise falls in plasma glutamine following a single bout of intensive exercise in female

athletes. 3rd international congress of the African Society for Physiological Sciences, Pretoria, 3 – 8

September 2000

3. Smith C, Myburgh KH. Sutherlandia frutescens supplementation influences the corticosterone response

to chronic stress in rats. 31st annual Congress of the Physiological Society of SA, Potchefstroom, 2003

4. Wilson NW, Smith C, Louw A, Myburgh KH. Peripheral antagonism of glucocorticoid action by

interleukin-6 probed in an in vivo model of psychological stress through utilisation of an anti-interleukin-

6 antibody. 33th annual congress of the Physiological Society of Southern Africa, Cape Town, South

Africa, 2005.

5. Myburgh KH, Smith C. The use of small laboratory animal models to elucidate physiological responses

to stress in various tissues. 33th annual congress of the Physiological Society of Southern Africa, Cape

Town, South Africa, 2005 (keynote).

11

6. Smith C, Erasmus PJ, Myburgh KH. Endocrine and immune effects of dexamethasone in unilateral total

knee-replacement. 34th annual congress of the Physiological Society of Southern Africa, Durban, South

Africa, 2006.

7. Myburgh KH, de Bruto P, Grobbelaar N, Smith C. Anthropometry and quality of life scores in female

patients with HIV/AIDS just before and up to 12 months after starting anti-retroviral treatment. 34 th

annual congress of the Physiological Society of Southern Africa, Durban, South Africa, 2006.

8. Myburgh KH, Kruger MJ, Smith RM, Smith C. Antioxidant (Oxiprovin™) supplementation and muscle

recovery from contusion injury – an in-vivo rat model study. 16th biennial congress of the South African

Sports Medicine Association, South Africa, 2007

9. Kruger MJ, Myburgh KH, Smith C. Cytokine profiles during recovery from experimental contusion injury

in rats. 37th annual congress of the Physiological Society of Southern Africa, Stellenbosch, South

Africa, 2009 (4th place in student competition).

10. Moyen M, Smith C, Myburgh KH. Co-morbidity in women on antiretroviral therapy: HIV, TB history,

lipodystrophy and hyperlactatemia. 37th annual congress of the Physiological Society of Southern Africa,

Stellenbosch, South Africa, 2009

7.1.4 National (Posters)

1. Mansvelt EP, Louw I, Serdyn C. Clinical and pathological findings in patients with ALL and meningeal

infiltration. 36th congress of the SA Society for Pathology, Kruger National Park, 1996.

2. Serdyn C, Myburgh KH. The intensity of match-play of a provincial level male tennis player: case report.

26th annual congress of the Physiological Society of Southern Africa, Rustenburg, 1998.

3. Smith C, Kohn T, Myburgh KH. Is fibre type a good indicator of lactate accumulation during submaximal

exercise in normoxia or hypoxia, or both. 3rd international congress of the African Society for

Physiological Sciences, Pretoria, 2000.

4. Robson PJ, Pool EJ, Smith C, Van Wyk JH, Myburgh KH. Immunosuppression in professional rugby

players: the use of interleukin-6 secretion by whole blood cultures as a diagnostic tool. 3 rd international

congress of the African Society for Physiological Sciences, Pretoria, 2000.

5. Smith C, du Toit J, Myburgh KH. The effect of a high-intensity training intervention on performance and

selected endocrine parameters in male cyclists. 30th annual congress of Physiological Society of

Southern Africa, Stellenbosch, South Africa, 2002.

6. Smith C, Myburgh KH. Selected immune and endocrine responses to increased training intensity. 31st

annual congress of Physiological Society of Southern Africa, Potchefstroom, South Africa, 2003.

7. Wilson NW, Smith C, A Louw, Myburgh KH. Decreased binding capacity of glucocorticoid receptors in

skeletal muscle previously frozen in liquid nitrogen. 31st annual congress of Physiological Society of

Southern Africa, Potchefstroom, South Africa, 2003.

8. Nell TA, Senekal M, Smith C. Analysis of ascorbic acid in biological samples. The 20th Biennial

Congress of the NSSA and the 8th Biennial Congress of ADSA.  Worcester, South Africa, 2004.

12

9. Smith C, Myburgh KH. IL-1β, IL-6 and peripheral blood mononuclear cells’ responses to intermittent

immobilisation: a rat model of chronic inflammatory stress. 32 th annual congress of Physiological

Society of Southern Africa, Coffee Bay, Eastern Cape, South Africa, 2004.

10. Van der Westhuizen JH, Nell T, Smith C, Van Rooyen J. Influence of a dose dependent RPO

supplementation on anti-oxidant status and reperfusion in Langendorff perfused rat hearts. 32 th annual

congress of Physiological Society of Southern Africa, Coffee Bay, Eastern Cape, South Africa, 2004.

11. Nell, TA, Senekal M, Smith C. Analysis of ascorbic acid in biological samples. 20 th biennial congress of

the NSSA and the 8th biennial congress of ADSA, Worcester, South Africa, 2004.

12. Wilson NW, Smith C, Louw A, Myburgh KH. Effects of neutralising IL-6 on glucocorticoid action in rat

tissue after exposure to short-term intermittent mild psychological stress. XIXth Conference of the South

African Society of Biochemistry and Molecular Biology, Stellenbosch, South Africa, 2005.

13. Prevoo D, Smith C, Swart P, Swart AC. An investigation into the stress relieving properties of

Sutherlandia frutescens by stydying the effect of the shrub on adrenal steroidogenesis. XIXth

Conference of the South African Society of Biochemistry and Molecular Biology, Stellenbosch, South

Africa, 2005.

14. Smith C, de Bruto PC, Myburgh KH. CD4+ lymphocyte count, anthropometry and quality of life scores in

female patients with HIV/AIDS just before and within 4 months of starting anti-retroviral treatment. 33 th

annual congress of the Physiological Society of Southern Africa, Cape Town, South Africa, 2005.

15. Kruger M, Smith R, Myburgh KH, Smith C. Development and characterisation of an in vivo model of

skeletal muscle contusion injury. 34th annual congress of the Physiological Society of Southern Africa,

Durban, South Africa, 2006.

16. Myburgh KH, Neethling I, Smith C. Early increases in 20s proteasome activity in fast and slow twitch

muscle of rats exposed to moderate psychological stress can be reversed by exercise. 34 th annual

congress of the Physiological Society of Southern Africa, Durban, South Africa, 2006.

17. Kruger MJ, Smith RM, Myburgh KH, Smith C. Antioxidant (Oxiprovin™) supplementation and muscle

recovery from contusion injury – an in-vivo study. 35th annual congress of the Physiological Society of

Southern Africa, Muldersdrift, South Africa, 2007.

18. Smith C, Essop MF. Assessment of metabolic risk factors in undergraduate students. 35th annual

congress of the Physiological Society of Southern Africa, Muldersdrift, South Africa, 2007

19. Engelbrecht, A-M, Smith, C, Brooks, N & Myburgh, KH. Chronically elevated levels of phosphorylated

p38 MAPK and ERK 44 in response to psychological stress in rodents. 35 th annual congress of the

Physiological Society of Southern Africa, Muldersdrift, South Africa, 2007

20. Visser K, Smith C and Louw A . Modulation of glucocorticoid action by interleukin-6 in a liver cell line.

XXIth Congress of the S.A. Society for Biochemistry and Molecular Biology, Grahamstown, South

Africa, 2008.

21. Myburgh KH, Qwemesha G, Smith C, Smith RM. Integrative approach to determining the effects of the

cytokine, IL-6, on skeletal muscle cells in vitro. 36 th annual congress of the Physiological Society of

Southern Africa, Pretoria, South Africa, Sept 2008.

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22. Smith C, Louw LC, Brand TJ. Effects of transport on blood chemistry and physiological stress indicators

in ostriches. 37th annual congress of the Physiological Society of Southern Africa, Stellenbosch, South

Africa, Sept 2009.

23. Janse van Vuuren M, Smith C. Role of IL-6 in the acute response to immobilization stress in Wistar rats.

37th annual congress of the Physiological Society of Southern Africa, Stellenbosch, South Africa, Sept

2009 (awarded 1st prize in student poster competition).

24. Delport CJ, Myburgh KH, Viljoen JT, Smith C. Treatment with proanthocyanidolic oligomer (PCO) may

alter the presence of adhesion molecules in skeletal muscle tissue samples before or after plyometric

exercise. 39th annual congress of the Physiological Society of Southern Africa, Bellville, South Africa,

Sep 2011.

25. Brand AM, Dicks LMT, Smith C, Smith RM. Immune response elicited in mice by nisin F administered

intraperitoneally. Annual conference of South African Society for Microbiology, Cape Town, November

2011.

26. Botha M, Dicks LMT, Botes M, Smith C. Transition of probiotic lactic acid bacteria through the horse

intenstine and physiological changes recorded. Annual conference of South African Society for

Microbiology. Cape Town, November 2011.

27. McGeachie L, Viljoen JT. Smith C. African drumming: just music, or also endurance exercise? 40 th

annual congress of the Physiological Society of Southern Africa, Stellenbosch, September 2012.

28. Roos M, Swart AC, Schloms L, Smith C. The effect of Rooibos (Aspalathus linearis) on adrenal

hormone and cytokine secretion. 40th annual congress of the Physiological Society of Southern Africa,

Stellenbosch, September 2012.

29. Krygsman A, Smith C. Adult-onset diet-induced obesity is associated with a pro-inflammatory response

and hyperinsulinaemia in the Wistar rat. 40th annual congress of the Physiological Society of Southern

Africa, Stellenbosch, September 2012.

30. Viljoen JT, Smith C. When the going gets tough, the tough goes on running. 40 th annual congress of the

Physiological Society of Southern Africa, Stellenbosch, September 2012.

7.1.5 Published Conference Proceedings

1. Myburgh KH, du Toit J, Smith C. Changes in performance and resting cortisol in response to 8 weeks of

high intensity training. Med Sci Sports Exerc 2002; 34(5S):S276, Saint Louis, Saint Louis, USA,

Lippincott H Williams and Wilkins.

2. Smith C, Myburgh KH. Mountain-bike racing: Glycogen status and glutamine supplementation effects

on white blood cells and endocrine responses. Med Sci Sports Exerc 2005; Saint Louis, Saint Louis,

USA, Lippincott H Williams and Wilkins.

3. Swart AC, Schloms L, Storbeck K-H, Smith C, Marnewick JL, Swart P. The influence of Aspalathus

linearis flavonoids on glucocorticoid biosynthesis. FEBS Journal 2011; 278 (Suppl.1) p.189 ISSN1742-

464X.

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4. Delport CJ, Myburgh KH, Viljoen JT, Smith C. Treatment with proanthocyanidin oligomer (PCO) may

alter the presence of adhesion molecules in skeletal muscle tissue samples before and after plyometric

exercise. Scientific Research and Essays 2012, vol 7, p. 51.

5. Swart AC, Schloms L, Smith C, Storbeck K-H, Roos MJ, Marnewick J, Swart P. Rooibos. A functional

food in the management of metabolic disorders? Siriraj Medical Journal 2012; 64(6) (suppl 2): 99.

7.2 Teamwork and collaboration with others:

7.2.1 Tertiary and research institutions

NationalStellenbosch University, Dept of Medical Physiology, Prof Barbara Huisamen

Stellenbosch University, Dept of Physiological Sciences, Prof Kathryn Myburgh

Stellenbosch University, Dept of Biochemistry, Prof Amanda Swart, Prof Ann Louw

Stellenbosch University, Dept of Microbiology, Prof Leon Dicks

Stellenbosch University, Dept of Psychiatry, Prof Soraya Seedat

InternationalUniversity of Northumbria, UK. Prof Paula Robson-Ansley

7.3 Membership in national and international organizations

7.3.1 International

International Society for Exercise Immunology

European College of Sport Sciences

American College of Sports Medicine

7.3.2 National

Physiology Society of Southern Africa Society of Medical Laboratory Technologists of South AfricaHealth Professions Council of South Africa (registered as Medical Technologist)

7.4 Visits to local and overseas universities or research institutes as guest professor or researcher

o Invited by Prof James Tidball of the University of California in Los Angeles, to visit his

laboratory and give guest lecture. June 2005

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o Invited by Dr Angus Scrimgeour of the US Army Research Institute for Environmental Medicine

(USARIEM), to visit his laboratory and give guest lecture. June 2005

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