18
A UNIVERSITY OF THE PUNJAB ffin .... o................. o. o. : W ,."-,,",,,fTl3,L'll*0fl3,0"1t" ,un".-.r., i..T*,1.,:*,...:;:;:.......:;:.i.. i Subject: Pharmacology & Therapeutics-Il TIME ALLOWED: 3 hrs. PAPER: 2 MAX. MARKS: 100 Ql. What is monoamine theory of depression. Classiff antidepressants. Describe mechanism of action, pharmacological properties, unwanted effects and interactions of tricyclic antidepressants. Q2. (a) Describe mechanism of action, antibacterial spectrum and adverse effects of macrolides (b) Describe bacterial mechanisms of antibiotic resistance with examples 20 Q3. (a) What is diabeties mellitus. Explain types of diabetes mellitus. (b) Give detailed account on sulphonylurea. 20 Q4. Illustrate diagrammatically cell-cycle specificity of antineoplastic drug classes. Discuss mechanism of action, therapeutic uses and adverse effects of Doxorubicin. 2_O Q5. Classiff antifungal drugs. Discuss the mechanism of action and resistance of Amphotericin B. 20 Discuss various principles of treatment of poisoning. Explain salicylates poisoning. 20 Write notes on the following (a) Diazepam (b) Digitalis poisonings

A UNIVERSITY OF THE PUNJAB o W ,.-,,,,,fTl3,L'll*0fl3,01t ,un.-.r.,pu.edu.pk/downloads/Past-Papers/PharmD/PharmD-3rd-Prof... · 2020. 7. 13. · Classiff antidepressants. Describe

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Page 1: A UNIVERSITY OF THE PUNJAB o W ,.-,,,,,fTl3,L'll*0fl3,01t ,un.-.r.,pu.edu.pk/downloads/Past-Papers/PharmD/PharmD-3rd-Prof... · 2020. 7. 13. · Classiff antidepressants. Describe

A UNIVERSITY OF THE PUNJABffin .... o................. o. o.

:

W ,."-,,",,,fTl3,L'll*0fl3,0"1t" ,un".-.r., i..T*,1.,:*,...:;:;:.......:;:.i.. iSubject: Pharmacology & Therapeutics-Il TIME ALLOWED: 3 hrs.

PAPER: 2 MAX. MARKS: 100

Ql. What is monoamine theory of depression. Classiff antidepressants. Describe mechanismof action, pharmacological properties, unwanted effects and interactions of tricyclicantidepressants.

Q2. (a) Describe mechanism of action, antibacterial spectrum and adverse effects ofmacrolides

(b) Describe bacterial mechanisms of antibiotic resistance with examples 20

Q3. (a) What is diabeties mellitus. Explain types of diabetes mellitus.(b) Give detailed account on sulphonylurea. 20

Q4. Illustrate diagrammatically cell-cycle specificity of antineoplastic drug classes. Discussmechanism of action, therapeutic uses and adverse effects of Doxorubicin. 2_O

Q5. Classiff antifungal drugs. Discuss the mechanism of action and resistance ofAmphotericin B.

20

20

  7

Q Q

Discuss various principles of treatment of poisoning. Explain salicylates poisoning. 20

Write notes on the following

(a) Diazepam

(b) Digitalis poisonings

20

Page 2: A UNIVERSITY OF THE PUNJAB o W ,.-,,,,,fTl3,L'll*0fl3,01t ,un.-.r.,pu.edu.pk/downloads/Past-Papers/PharmD/PharmD-3rd-Prof... · 2020. 7. 13. · Classiff antidepressants. Describe

6)( $r1 I

..E[8H,Flaa"N7l'

Subjcct:

PAPER:

Pharmacology & Therapeutics-II,

Classify Narcotics Analgesics. Discuss the Pharmacology of Morphine. (20)

Classify General Anesthetic? Explain in Detail the Pharmacokinetics and

pharmacodynamics of Thiopental & Nitrous Oxide. (20)

Classify Anxiolytics. Describe the pharmacological action, clinical uses and

adverse effects of Benzodiazepines. (20)

Classify Alkylating agents. Discuss the mechanism of action, therapeutic uses and

adverse effects of Cyclophosphamide & Doxorubicin. (20)

Classify Antiretroviral Drugs. Discuss the mechanism (s) of action and resistance

of Zidovudine & Amantadine. (20)

Classify p-Lactum Antibiotics. Discuss the mechanism of action and therapeutic

uses of Cephalosporins? (20)

Define POISON. Discuss various principles of treatment of Poisoning. Explain

oRGANOPHOSPHOROUS COMPOUND. (20)

UNIVERSI TY OF TⅡE PUNJ ABThird Prof. N2016

Examination: Doctor of Pharmacv (Pharm.D')

  2

3.

4.

5.

6.

7.

1-

NOTE: Attempt any FIVE questions. All questions carry equal marks.

一     ‘

Page 3: A UNIVERSITY OF THE PUNJAB o W ,.-,,,,,fTl3,L'll*0fl3,01t ,un.-.r.,pu.edu.pk/downloads/Past-Papers/PharmD/PharmD-3rd-Prof... · 2020. 7. 13. · Classiff antidepressants. Describe

Subi eCt :PAPER:

UNIVERSI TY OF THEThi rd Pro■ 2nd A/2016

PUNJ AB

Examination: Doctor of Pharmacy (Pharm.D.)

Pharmacology & Therapeutics-Il

2

●・ ・ ・ ・ ・ ・ ・ ・ ・● ● ● ● ● ● ● ● ● 00● 000。

: Rol l No。 . . . . . . ¨ ¨ ・・・・・・・ … ・:

●. . . . . 。 . . 。 ● ● ● ● ● ● ● ● ● ● ● ● 0● 0°

TIME ALLOWED: 3 hrs.MAX. MARKS: 100

1.

NOTE: Attempt any FIVE questions. All questions caruy equal marks.

Classify NSAlDs. Discuss the Mechanism of action, Pharmacological and untoward

effects of Aspirin. (20)

Classify Antidepressant Drugs. Discuss the Pharmacology of SSRIs and MAOls. (20)

Describe the Life cycle of Malarial Parasite Plasmodium falciparum. Discuss the

Mechanism of action, Pharmacokinetic and Anti-malarial spectrum of Chloroquine &

Primaquine. (20)

a) What are different classes of natural compounds used as Cytoxic agents? (10)

Discuss the Mechanism of action of Paclitaxel (Taxol) & Cisplatin. (10)

Discuss the Mechanism of action, Antibacterial spectrum and contraindication of

Macrolides. Cao)

a) Classify Antifungal drugs. (08)

Discuss the mechanism of action and adverse effects of Amphotericin B &

Griseofulvin. (12)

7. Classify Antiviral drugs. Discuss the Mechanism of action and therapeutic uses of

Acyclovir & lnterferons. (20)

 

 

 

 

bi

Page 4: A UNIVERSITY OF THE PUNJAB o W ,.-,,,,,fTl3,L'll*0fl3,01t ,un.-.r.,pu.edu.pk/downloads/Past-Papers/PharmD/PharmD-3rd-Prof... · 2020. 7. 13. · Classiff antidepressants. Describe

UNIVERSI TY OF THE PUNJ ABThird Prof: Annual - 2017

Examination: Doctor of Pharmacy (Pharm.D.)

Sut t eCt : Pharmacol ogy&Therapeut i cs― I I ( 01d&New Course) TIME ALLOWED: 3 hrs。MAXo MARKS: 100PAPER: 2

NOTE: Attempt any FIVE questions, All questions carry equal marks.

a) Classiff antifungal drugs'

b) Discuss the mechanism of action and adverse effects of Azoles'

Describe the life cycle of Plasmodium and discuss the mechanism of action,

pharmacokinetic and antimalarial spectrum of Artemesinin'

a) What are the different classes of natural compounds used as cytotoxic agents? (10)

b) Discuss the mechanism of action and adverse effects of Vinca alkaloids' (10)

Discuss the mechanism of action and resistance of Penicillins. (20)

Describe different types of epileptic seizures. Write down the mechanism of action'

plrarmacokinetic, clinical uses and adverse effects of phenytoin. Q0)

Classiff antiviral dnrgs. Discuss the mechanism of action and therapeutic uses of

amantatine

a) Discuss the treatmet strategies of Acetaminophen-induced tocxicities.

b) Discuss the pharmacology of levodopa.

′・・・・ ° ° ° ° ° 00● ● ● ●● ● ● ●● ●● ●.

: Rol l No. ¨ . . " . . . . ● “ "● ●…・ :●. . . 。 。 . . . . ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●・

Ql .

Q2.

Q3.

Q6.

Q7.

Q4 

Q5

( 10)

( 10)

( 20)

( 20)

( 10)

( 10)

Page 5: A UNIVERSITY OF THE PUNJAB o W ,.-,,,,,fTl3,L'll*0fl3,01t ,un.-.r.,pu.edu.pk/downloads/Past-Papers/PharmD/PharmD-3rd-Prof... · 2020. 7. 13. · Classiff antidepressants. Describe

UNIVERSITY OF THE PUI\JAB'fhird Prof: 2'd Annual -20L7

o"t'!r""..'o"t"r"'o'aa

Examination: Doctor of Pharmacv (Pharm.D.) ! Ro11 No. ..................... :oo lrlltta al t aaaaaaaa at a a ao

SuЦ eCt : Pharmacol ogy&Therapeut i cs‐ I I ( Ol d&New Course) TIME ALLOWED: 3 hrs.PAPER: 2 MAX. MARKS: 100

NOTE: Attempl ony FIVE questions. All questions carry equal mork*

Classiff antimetabolite agents. Discuss the mechanism of action, therapeutic uses andadverse effects of methotrexate.

eO)

Classifu antidepressant drugs. Discuss the pharmacological actions, and adverse effectsof tricyclic antidepressants.

eO)

classifu ge.eral anesthetics? Exprain in detail the pharmacokinetics andpharmacodynamics of thiopental

( 20)

Classify B-lactum antibiotics. Discuss the mechanism of action, clinical uses and adverseeffects of cephalosporins. (20)

Classify antifungal drugs. Discuss the mechanism of action, clinical uses and adverseeffects of amphotericin B.

( 20)

Classi$ antiretroviral drugs. Discuss the mechanism(s) of action and resistance ofZidovudine

eO)

Classi$u NSAIDs. Describe mechanism of action, pharmacokinetics and unwanted effectof Aspirin.

( 20)

Ql .

Q2.

Q3.

Q4.

Q5.

Q6.

Q7.

Page 6: A UNIVERSITY OF THE PUNJAB o W ,.-,,,,,fTl3,L'll*0fl3,01t ,un.-.r.,pu.edu.pk/downloads/Past-Papers/PharmD/PharmD-3rd-Prof... · 2020. 7. 13. · Classiff antidepressants. Describe

レ` ″

″ uヾЧ e“ Pharmacol ogy&Therapeuacs_Ⅱ ( New Course)rAPER: 2( Part― Ⅱ)

. ●● ● ● ● ● ● ● ● ● ● ● 0● ● ● 00● ● 0● ● ●.

: Rou No。 ". . . . . . . ・・・̈・・・…・ :|. . . 。 。 . . . . ● ● ● ● ● ● ● ● 0● ● ● ● ● 0°

TIME ALLOWED: 2 Hrs. &30 mi n。MAXo MARKS: 80

Attempt this Paper on Seporate Answer Sheet provided.

At t empt anv 4 quest i ons. Each quest i onゎ carrv equal marks.

Q2. Cl asJ f y ant i met abol i t es, Di scuss t he mechani sm of act i on′ t herapeut l c uses and adverse ef f ect s of

methot rexat e. ( 20)

Q 3. Classify antifungal drugs. Discuss the mechanism(s) of action and resistance of Azoles. ( 20)

Q 4. a) Classify antibiotics which inhibit Protein and Cell wall synthesis.

b) Discuss the mechanism of action and adverse effects of Aminoglycosides?

( 10)

( 10)

Q 5. Classify Anxiolytics. Describe the pharmacological actions, clinical uses and adverse effects of

Benzodiazepines. (20)

Q 6. Classify general anesthetics? Explain in detail the pharmacokinetics and pharrnacodynamics of

Thiopental? (20)

Q 7 a) Discuss the mechanism of action and adverse effects of Metronidazole. (10)

b) Describe the mechanism(s) of action, clinical uses and adverse effects of Albendazole. (10)

Page 7: A UNIVERSITY OF THE PUNJAB o W ,.-,,,,,fTl3,L'll*0fl3,01t ,un.-.r.,pu.edu.pk/downloads/Past-Papers/PharmD/PharmD-3rd-Prof... · 2020. 7. 13. · Classiff antidepressants. Describe

UNIYERSITY OF THE PUNJAB "..Thi rd Prot t Annual - 2018

n:

Subject: Pharmacology & Therapeutics-Il (New Course)

*.r. PAPER: 2 Part-I (Compulsory)

please encircle the correct statement. Each MCO carries 1 Mark ' This PaDer wi[ be collected back

after expim of time limit mentioned above.

Q 1. MCQs '

l. Regarding acyclovir, which of the following statements is correct?

a) lt acts to inhibit viral entry into cells

b) lt is'a guanosine analogue

c) lt is commonly given in doses of 10-20 mg TDS d) lt is used to treat CMV

ll.Regardingamantadine,whichofthefollowingstatementsiscorrect?

a) lt potentiates dopaminergic function

b) lt il an antiviral drug

c) lt causes acute PsYchosis

d) All of the above

lll. Zidovudine is an analogue of

a)Thymidine

b) Uracil

c) Guanosine

d) Cytosine

lV, one of the following drugs binds with tubulin & arrest the cell cycle in metaphase

a) Mechorethamine

b) Methotrexate

c) Vincristine

d)Chlorambucil

V. T.he drug used to treat Methotrexate toxicity is

a) Mesna

b) Folic acid

c) Folinic acid

d) Acetylrysteine

Vl. One of the following drugs causes cardiotoxicity

a) Paclitaxel

b) Vinblastine

c) Adriamycin

I

d) M'ethotrexate

Page 1 0f 3

37

RolI No.

\TIME ALLOWED:30 min.

"MAX. MARKS:20

Page 8: A UNIVERSITY OF THE PUNJAB o W ,.-,,,,,fTl3,L'll*0fl3,01t ,un.-.r.,pu.edu.pk/downloads/Past-Papers/PharmD/PharmD-3rd-Prof... · 2020. 7. 13. · Classiff antidepressants. Describe

ラg

Vll. Drug of Choice for CMV infection is

a) Lamivudine

b) Ganciclovir

c) Acyclovir

d) Abacavir

vlll. Use of metronidazole in hepatic encephalopathy is due to lts ability to

a) lnhibit the production of intestinal toxins

b) Convert ammonia in to urea

c) Decrease intestinal absorption of ammonia

d) Bind with serum ammonia

lX. Clofazimine is associated with the following features EXCEpT,

a) Anti-inflammatory activity

b) Skin discoloration

c) Effective in multibacillary leprosy

d) Major renal excretion

X' lndicate the local anesthetic agent which has a shorter duration of action

a) Lidocaine

b) Procaine

c) Bupivacaine

d) Ropivacaine

Xl. The primary mechanism of action of local anesthetics is

a) Activation of [igand-gated K+ 6h2n6915

b) Blockade ofvoltage-gated Na+ channels

c) Stimulation of voltage-gated Na+ channels

I

d) Bldckade of GABA-gated Cl- channels

Xll. Which drug inhibit the protein synthesis in bacteria

a) Tetracyclines

b) Penicillins

c) Cephalosporins

d) Monobactams

xlll. Resistance to chloramphenicol is due to one of the following mechanisms

a) Effluxofdrug

b) Production of transferases

c) lnactivation by p lactamases

d) Both a and c

page 2 of3

r‐

Page 9: A UNIVERSITY OF THE PUNJAB o W ,.-,,,,,fTl3,L'll*0fl3,01t ,un.-.r.,pu.edu.pk/downloads/Past-Papers/PharmD/PharmD-3rd-Prof... · 2020. 7. 13. · Classiff antidepressants. Describe

3ノ

XlV. One of the following is not penicillinase susceptible

a) Amoxacillin

b) penicillin G

J c) piperacillin

d) Cloxaciilin

XV. Macrolides

a) Have.enhanced activity at acidic pH

b) Have little activity against legionella

c) Have half lives which increase in patients with anuria d) lnduce cytochrome p450 enzymes

XVl. Which of the following opioid analgesics is a partial !r receptor agonist?

a) Morphine

b) Methadone

c) Buprenorphine

d) Sufentanyl

i

XVll. For which of the following conditions could aspirin be used prophylactically?

a) Non cardiogenic pulmonary edema

b) Peptic ulcers

c) Thromboembolism

d) Metabolic acidosis

XVlll. lndicate the psycho-stimulant, which is a methylxanthine derivative

a) Caffeine

b) Cocaine

c) Amphetamine

d) LsD

XlX. lntravenous Flumazenil

a) Has intermediate onset and duration of action about 2 hours

b) Acts rapidly but has a short half-life

c) Has an effect lasting 3-5 hours

d) Has duration of action longer than 5 hours

XX. lvermectin exerts antihelminthic effect via

a) Blockage of nicotinic receptors

b) lnhibition of cholineesterase

c) lnhibition of acetylcholine secretion

d) lncreased GABA transmission

Page 3 of3

Page 10: A UNIVERSITY OF THE PUNJAB o W ,.-,,,,,fTl3,L'll*0fl3,01t ,un.-.r.,pu.edu.pk/downloads/Past-Papers/PharmD/PharmD-3rd-Prof... · 2020. 7. 13. · Classiff antidepressants. Describe

UNIVERSI TY OF THE PUNJ ABThi rd PrO■ 2nd Amual - 2018

subject: Pharmacorogy & Therapeutics-Il (old cource)PAPER:2

: |: : i i l : |: : : |: ||: |: |: : |:

嘔 TIME83 Hrse暉 . ― KS3 100

Ⅳつ巴 、/ “ ″ η ″′ αψ Ff t t gt t s働′鶴. ∠″ 響“as鱒0■ scα η ″g“ αJ ′ 知

"=襦・

Q 1. Classify NSA|Ds. Give nrechanism o(action, therapeutic uses and adverse effects of Asprin.

Q 2. a) Classify Anticancer drugs?

b) Discuss the mechanism of action and clinical uses of Methotrexate.

Q 3' Classify Antiviral drugs. Discuss the mechanism of action and therapeutic uses of Acyclovir.

' Q a. a) Discuss the mechanism of action and untoward effects of Fluoxetine,

b) Discuss the mechanism of action and clinical uses of Morphine.

Q 6' a) What are General Anesthetics? Classify lnhalation and lntravenous Anesthetics.

b).Discuss the pharmacology of Nitrous oxide.

Q 7. a) Describe the mechanism of action and adverse effects of Artemesinin.

b) Describe the mechanism o.r action and adverse effects of Rifampecin.

P0

( 20)

η 呵

( 10)

( 10)

I Q5' classifu p-lactam antibiotics. Discuss the mechanism of action, clinical uses and adverse effects of'Penicillin G.

(20)

( 10

{10

( 10)

( 10

Page 11: A UNIVERSITY OF THE PUNJAB o W ,.-,,,,,fTl3,L'll*0fl3,01t ,un.-.r.,pu.edu.pk/downloads/Past-Papers/PharmD/PharmD-3rd-Prof... · 2020. 7. 13. · Classiff antidepressants. Describe

IINIVERSITY OF TIIE PUNJABThi rd Pronノ d Annual … 2018

Subjecf Pharmacolory & Therapeutics-Il (New Course)

. ●● 0● ● ● ● 10111000000000001・

l 1191r191=: ∵ : =: ∵: =: ∵ : 1. I

― TIME: 2 Hrs. 30 Mi n.こヽA】C MARKS: 80PAPER: 2 Part― Ⅱ

_NOTE:

Q 2. a) What are different sub classes of Alkylating agents used as Anticancer drugs?

b) Discuss the mechanism of action and clinical uses of Cyclophosphamide.

Q4. a) Discussthe mechanism ofaction and untoward effects of Amitriptyline.

b) Discuss the mechanism of action and clinical uses of Morphine.

Penicillins.

Q 6. a) what are General Anesthetics? classify lnhalation and lntravenous Anesthetics.

b) Discuss the pharmacology of Nitrous oxide.

Q 7. a) Describe the mechanism of action and adverse effects of Artemesinin.

b) Describe the mechanism of action and adverse effects of Rifampacin.

Q 3. Classify Antiviral drugs. Discuss the mechanism of action and therapeutic uses of Acyclovir. (20)

( 10)

{ 10)

( 10)

( 10)

( 20)

( 10)

{ 10)

{ 10)

( 10)

- Q5. Classify g-lactam antibiotics. Discuss the mechanism of action, clinical uses and adverse effects of

Page 12: A UNIVERSITY OF THE PUNJAB o W ,.-,,,,,fTl3,L'll*0fl3,01t ,un.-.r.,pu.edu.pk/downloads/Past-Papers/PharmD/PharmD-3rd-Prof... · 2020. 7. 13. · Classiff antidepressants. Describe

UNIVERSI TY OF THE PUNJ ABThi rd Pro■ 2nd An■ ■al - 2018

Pharmacology & Thenpeutics'Il (New Course)

2 Part-I(ComPulrorY)

Q。 1。 Enci rcl e t he nght answer cut t ng and over7J 減●l g i S■ 91 al 1077ed。

i . What are t he two mai n t arget s Current l y used i n ant i ― Hi V t herapy? ‐

a) Reverse transcriptase and protease

b) Reverse transcriptase and integrase

c) Protease and integrase

d) The viral glycoproteins gp120 and gp41

ii. Regarding Zidovudine (AZT), which of the following statements is coRREcT?

a) lt'has a similar mechanism of action to amantadine

b) lt is not used to treat retroviruses

c) lt has a short half life

d) lt blocks thYmidine kinase

iii. Which of the following is Tyrosine Kinase lnhibitor?

j- a) lnfliximab

'b)lmatinib

c)AcYclovir

d) ldoxuridine

iv. One of the following drugs binds with t ubul i n&arrest t he cen cyCl e i n met aphase

a) Paclitaxel

b) CyclophosPhamide

c) Methotrexate

;

v. All are correctlY Paired excePt

a ) CYcloPhosPhamide-CYstitis

b) BusulPhan-PulmonarY fibr:osis

c) Paclitaxel-Neurotoxicity

d) Vincristine-Bone marrow suppression

vi. Which enzyme combination is involved in Ergosterol biosynthesis?

a, a) Lanosterol l4alpha demethylase and Squalene epoxidase

b) Lanosterol epoxidase and Squalenel6alpha demethylase

c) Lanosterol epoxidase and Squalenel4alpha demethylase

d) Lanosterol l6alpha demethylase and Squalene epoxidase

vii. The mode of action of Polyenes involve

a) Loss of membrane integrity and influx of CaZ+

b) lnhibition of reproductive function

c) Binds to Ergosterol d) Destruction of pore-like molecular ag8re8ates

Rol l Na l n ng. ¨ . ¨ 。… ●●●●・̈・・"… …ヽ

、` Rol l Noei n WOrds, . . . . "“ ●●"“ ・ヽヽ`ヾ°・・・・・・・●●●●●●●●●|● ●"・・●●"●・ "●

Sut t eCt :PAPER3

MAX. TIME8301ヽ1[ ′ L: ' 【I MAN:

Mi n)ヽ 、

20 `ヽ

of SuPdt.:

00Xl 親0

Page 1 of3

Page 13: A UNIVERSITY OF THE PUNJAB o W ,.-,,,,,fTl3,L'll*0fl3,01t ,un.-.r.,pu.edu.pk/downloads/Past-Papers/PharmD/PharmD-3rd-Prof... · 2020. 7. 13. · Classiff antidepressants. Describe

viii. Prophylactic drug in meningococcal meningitis

a) penicillin

b) Ceftriaxone

c) Erythromycin

d) Rifampicin

ix. Ceftriaxone is a

a) First generation, oral antibiotic

b) Third generation, parenteral antibiotic

c) Second generation, oral antibiotic

d) Fourth generation, parenteral antibiotic

x. Drug of choice for bacterial Vaginosis is

a)Metronidazole

b)Ampicillin

c)Acyclovir

d) Fluconazole

xi. Which drug inhibits the protein synthesis in bacteria

a) Tetracyclines

b) Penicillins

c) Cephalosporins

d) Monobactams

xii. lndicate the local anesthetic agent which has a shorter duration of action

a) Lidocaine

b) Procaine

c) Bupivacain

d) Ropivacaine

xilt. lhe anesthetic, which is used intravenously

ai Propofol

b) Halothane

c) Desflurane

d) Nitrous oxide

page 2 of3

)ヽノ

で~

―~

Page 14: A UNIVERSITY OF THE PUNJAB o W ,.-,,,,,fTl3,L'll*0fl3,01t ,un.-.r.,pu.edu.pk/downloads/Past-Papers/PharmD/PharmD-3rd-Prof... · 2020. 7. 13. · Classiff antidepressants. Describe

xiv.Theinhaledanesthetic,whichreducesarteriaIpressureandheartrateis

a) lsoflurane

b) Halothane

c) Desflurane

d) Nitrous oxide

xv. All of the following are undesirable effects of aspirin EXCEPT

a) Gastritis with focal erosions

b) Tolerance and physical addiction

c) Bleeding due to a decre-ase of platelet aggregation

d) Reversible renal insufficiency

xvi.whichofthefollowingopioidanalgesicsisapartialureceptoragonist?

. a) MorPhine

b) Methadone

c) BuPrenorPhine

, d) SufentanYl

':. xvii. All of the hypnotic drugs

a) lncrease the duration of REM sleep

' b) Decrease the duration of REM sleep

c) Do not alter the duration of REM sleep

d) lncrease the duration of slow wave sleep

xviii.lndicatethepsychostimulant'whichisamethylxantinederivative

a) Caffeine

b) Cocaine

c) AmPhetamine

d) LsD

moPhilus influenzae infectionxix. one of the following is also used for the prophylaxis of Hae

a) lsoniazid

b)RifamPicin

t c) Pyrazinamdet-. -

d) Ethambutol '

xx. clofazimine is associated with the following features EXCEPT

a) Major renal excretion

b) Anti-inflammatorY activitY

c) Skin discolouration

d) Effective in multibacillary leprosy page 3 of 3

Page 15: A UNIVERSITY OF THE PUNJAB o W ,.-,,,,,fTl3,L'll*0fl3,01t ,un.-.r.,pu.edu.pk/downloads/Past-Papers/PharmD/PharmD-3rd-Prof... · 2020. 7. 13. · Classiff antidepressants. Describe

eD∝ 謂躙 曝 : [ : 職 ギ

螺 AL“ 9

Subject:Paper: 2

'. Roll No. in Fig.

".Roll No. in words. ...........'

Pharmacology & Therapeutics-tl (New Course)Time:15 Min. Marks:l0

"."""'Part - I (ComPulsorY)\..............'.gignature of SuPdt.:

\ \\

B0x1-"eP)Q.{. Encircle the correct oPtion'

i, Atl tbe followlng arc rretebolized to desuethyldtrzcprm exccpt:

a) Pmzepam

b) DiazePam

c) FlurazePam

d) ClorazcPete

il Which bcnzodhzcpine hes thc rbortert hrlf'life:

a) ZalcPlon

b) Triazolam

c) ZolPidem

d) EszoPiclone

tiil HyPotic dore of Eltrzohm is:

a) 0.5 *2 mg

b) 2-4mgc) 0.125 - 0'5 mg

d) 2.5 - l0mg

iv.Benzodlazeplncst'Gcllnicallyu,redfordlttccondltlols.rccPt:

a) Panic attacks

b) Insomnia

c) Seizuredisorden

d) Muscle relorant

is uged for absence scizureri

a) Vigabarrin

b) Tiagabine

c) Retigabine

d) Ethosuximide

vl. Durrtlon of rctton of Kctrminc ig:

a) 5-l0minb) l0 - 20 minc) 15 - 30 mind) 60 - 120 min

vii Whleh rntiprrklnronirn ir e MAO'B inhiblton

a) l*vodoPa

b) Selegiline

c) Amantadine

d) OrPhenadrine

vili. Whlch rutipsychotlc drug hes verX lor hypolcnrivo rctlon:

a) ChlorPromazine

b) Thiothixerre

c) ClozaPine

d) Fluphurazine

ir. whrt ls the minimum cffcctivc therrpcudc do3c (mg) of clozaplnc:

↓D

cり0

5

r0

30

50P.T.O.

Page 16: A UNIVERSITY OF THE PUNJAB o W ,.-,,,,,fTl3,L'll*0fl3,01t ,un.-.r.,pu.edu.pk/downloads/Past-Papers/PharmD/PharmD-3rd-Prof... · 2020. 7. 13. · Classiff antidepressants. Describe

r. All the lollowingcephrlosporlas trcglven l,ntrevcnously crccptr

a) Cefazolin

b) Cephalexin

c) Cefoxitin

d) Ccfuroximc

r[ Vuconycin lr givcn ill

a) Pneumonia

b) Urinary tract infection

c) Endocarditis

d) Soft rissuc infections

rii. All rhc followlng drTgr blld to 50r rtboroud rubunlt crccptl

a) Teuacycllio

b) Erythromycin

c) Clindanoycin

d) Linezolid

$it Wtlch itrlemc&t h corrcct rcg.dlng Geatrryclu

a) It causes rcversible Nephrotoxicity

b) It causcE rrversiblc Ootoxicityc) Ir causcs irrcvcrcible Ootoxicityd) It causcs ireversiblc Nephmroxicity

rlv. Whicb rntimyeobrctcr.lrl drug tnhlblts tbe ryntbecir of Myoollc rcld:

a) Rifampicin

b) Pyrazinamide

c) lsoniazid

d) Ethanbutol

rv. ffihf, sallfurgrl dnrg l&ibitr thc coDveElo! of Lrlo$crcl lo Ergodcro}

a) Itaconazole

b) Terbinafinc

c) Flucytosine

d) Amphorcricin B

rvl All the followiug rntifuryrt dru3s erc cltnftrrlcd vle thc tivcr crccpir

a) Ketoconazolg

b) Itaconazolc

r) Fluconazolc

d) Voriconazole

xvii. Whlch rntifungal drug blockr fungal p4S0 enzymcs:

a) Fltrcytosine

b) Kctocoruzole

c) Caspofungin

d) Terbinafine

rvliL Rccommended rdult dosrge of Entecrvlr for tbe trcrtment of chronhHeprlltls-B lnfecilou is:

a) 100 mg gd orallyb) 200 mg qd orally

c) 300 mg qd orallyd) 500 or 1000 mg qd orally

rix. Olc of the followlng ccll cyclc rpecllic h dnrg thtt.ctr otr S phrcc of cdlcycle:

a) Paclitaxel

b) Cytarabinc

c) Vincristine

d) Bleomycin

xx. Whtch geuerrl rnerthetlc is glven intrevcnously:

Propofol

Halothane

Dcsflurane

Nitrous oxide

↓り

o>0

Page 17: A UNIVERSITY OF THE PUNJAB o W ,.-,,,,,fTl3,L'll*0fl3,01t ,un.-.r.,pu.edu.pk/downloads/Past-Papers/PharmD/PharmD-3rd-Prof... · 2020. 7. 13. · Classiff antidepressants. Describe

UN: VERSI TY OF THE PUNJ AB : ・ "° ° ・̈・"oo¨ "Oo■Doct or of Pharl nacy( Pharl n. D。) Thi rd Pr。 ■ Annua卜2019 1191191: : : =: : : ・ : ∵ : . :

: : : 1°Ct : l hal l , 「°bgy a Therapeut l cs‐ l i ( New Cout t e)

Ti me: 2 Hr8. 45 Mi n. Mark6: 80

Note: Attempt any FouR questions. Each question carries equar marks.

Q-2 a) Classify anticancerdrugs.b) Discuss the mechanism of action and clinical uses of Vincristine.

( 10り

( 10)

Q‐ 3

Q‐ 4

Q‐ S

llassify tutiviral drugs. Discuss the mechanism of action and thenpeutic uses ofInterferons. (20)

a) Discussthe mechanism ofaction and untoward efects ofFluxetine. (t0)b) Discuss the mechanism of action and adverse effects of Aspirin, ilOl

classify cell wall synrhesis inhibiring antibiotics. Discuss the mechanisn of actio&and adverse elfects ofCephalosporins. (20)

a) What are Gcneral Anesttretics? Give the pharmacology of Halothane. (10)b) Discussthc pharmacology ofCocaine. itOi

a) Describe the management of Arsenic intoxication. (10)b) Dacdbe the management of Morphine poisoning. (tOi

o7

Page 18: A UNIVERSITY OF THE PUNJAB o W ,.-,,,,,fTl3,L'll*0fl3,01t ,un.-.r.,pu.edu.pk/downloads/Past-Papers/PharmD/PharmD-3rd-Prof... · 2020. 7. 13. · Classiff antidepressants. Describe

畠呻

Q̈‐ ∝

Q4

Q‐ 5

Q‐ 6

Q‐ 7

UNi VERSI TY OF THE PUNJ ABDoctOr of Pharmacy( Pharm・ D. ) Thi rd PrOf : Annual … 2019

Pharmacol o9y&Therapeut i CS‐ l l ( 0: d COurSe)

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ヽ

: Ro‖ No. ¨ ¨ . ・ … …・・ …・・ :ヽ o・・ ・ ・ ・ ・ ・ ・

● ● ●・ ・● ● ● ●・ ・

t 20)

( 10)( 10)

( 20)

( 10)( 10)

( 10)( 10)

Q‐ 3

Note: Attempt any FIVE questions' Each question carries equal marks'

Write down rhe Pharmacology of Morphine' (20)

Classifr antimetabolites. Discuss the mechanism of action' theraoeutic uses 8rrd

advcrce effects ofmethotrexarc (20)

Cl assl 取 ant i Vi ral drugs, Di scuss t he mechani sm( s)。 f act i On and redSt ance Of

acycl ovi r .

3説瀧: 犠翼慧 1霧策t l 鶴器翼魅盤ぽ罵瀬pt yl ma

風霊P謝為i 群霞l 肥憎讐盤闘∝・Di scsぬe mec面師J act i OLcycl i nes.

3織認需潮甜猟網 : mal dm m l nt ravems Anest hふoxi de.

3剛蹴蹴闊‖薔: 搬胤 ・

Time: 3 Hrt, Marks: {00