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A traditional Chinese medicine used in modern science
Flavonoids
IntroductionFlavonoids are nearly ubiquitous in plants and are
consumed regularly with the human dietCertain plants and spices containing flavonoids have been
used for thousands of years in traditional Eastern medicineThey are usually subdivided into
flavanols anthocyanidins flavones flavanones chalcones
The flavonoids display
a remarkable array of biochemical and
pharmacological
actions
Direct effect on mitochondrial calcium uniporter
effects of several of the most naturallyabundant flavonoids on mitochondrial Ca2+ uptake in
permeabilizedHeLa cells
Concentration dependence of the activation of mitochondrial Ca2+
uptake by several natural flavonoids
Reversible activation of mitochondrial Ca2+ uptake by kaempferol
in permeabilized cells
Inhibition by Ru360 of themitochondrial Ca2+ uptake induced bykaempferol and SB202190
Effect of the absence of ATP in the activation of mitochondrialCa2+ uptake by genistein or SB202190
attenuate apoptosis andprotein oxidation in neuronal cell
lines
Scavenging effects of flavones on reactive oxygen species generated
by GO
Effect of flavone pretreatment on apoptosis in neuronal cells exposed to oxidative stress
Effect of flavone pretreatment on the Bcl-2- and Bax-protein levels
Effect of flavone pretreatment on the phosphorylation of Bcl-2 and
Bax proteins
Effect of flavone pretreatmenton protein carbonyl formation
Antioxidant Activity
flavonoids,as a dietary antioxidants, possess the potential to scavenge and quench various radicals and ROS
As a antioxidant,flavonoids can function as below
Metal chelator
scavengers of ROS
chain-breaking antioxidants
quenchers of the formation of singlet
oxygen
LOO· + FL-OH LOOH + FL-O·
Effect of flavonoids on lipid peroxidation
suppress lipid peroxidation
Flavonoids
Enzymatic lipid peroxidation
Nonenzymaticlipid peroxidation
Impairment oflipid peroxidation
Cytochome P450
Free radical species
The illustrations above are only parts of the functions of flavonoids,which I think will be connective to my research on brain ischemia and reperfusion.
In addition,the flavonoids also possess anti-inflammatory,antiallergic,hepatoprotective,
antithrombotic, antiviral, and anticarcinogenic activities
Thank you !Thank you ! Lin LinLin Lin
2005.6.10.2005.6.10.