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A Study of Atezolizumab (Anti−Pd-L1 Antibody) as Adjuvant Therapy After Definitive Local Therapy in Patients With High-Risk Locally Advanced Squamous Cell Carcinoma of the Head and NeckNCT-Nummer:NCT03452137
Studienbeginn:April 2018
Letztes Update:22.07.2019
Wirkstoff:Atezolizumab, PlaceboIndikation (Clinical Trials):Carcinoma, Carcinoma, Squamous Cell, Squamous Cell Carcinoma of Head and Neck
Geschlecht:Alle
Altersgruppe:Erwachsene (18+)
Phase:Phase 3
Sponsor:Hoffmann-La Roche
Collaborator:-
Studien-InformationenBrief Summary:
This study will evaluate the efficacy and safety of atezolizumab compared with placebo as adjuvant therapy after definitive local therapy in patients with high-risk locally advanced
squamous cell carcinoma of the head and neck (SCCHN)
Ein-/AusschlusskriterienInclusion Criteria
- Histologically or cytologically confirmed Squamous Cell Carcinoma of the Head and Neck (SCCHN)
- Human Papilloma Virus (HPV) status
- Completed definitive local therapy
- Absence of metastatic disease as documented by radiographic scans
- Adequate hematologic and end-organ function
- For patients receiving therapeutic anticoagulation: stable anticoagulant regimen
- For women of childbearing potential: agreement to remain abstinent or use contraceptive methods with a failure rate of < 1% per year during the treatment period and for 5 months after the last dose of study treatment. Women must refrain from donating eggs during this same period.
- Confirmed response of Complete Response (CR), Partial Response (PR), or Stable Disease (SD) to definitive local therapy documented by CT with contrast or MRI with contract to head and neck region done >= 8 weeks after completion of definitive local therapy and within 28 days prior to initiation of study drug.
Exclusion Criteria:
- Patients who have received surgery alone or radiotherapy alone as definitive local therapy
- Squamous cell carcinoma of the nasopharynx or paranasal sinuses or non-squamous histology
- Evidence of disease progression or metastatic disease during or following definitive local therapy documented in post-definitive local therapy screening scans
- Uncontrolled or symptomatic hypercalcemia
- Active or history of autoimmune disease or immune deficiency
- Active tuberculosis
- Significant cardiovascular disease
- History of malignancy, including prior SCCHN primary tumors within 5 years prior to screening, with the exception of malignancies with a negligible risk of metastasis or death
- Prior allogeneic stem cell or solid organ transplantation
- Current treatment with anti-viral therapy for Hepatitis B Virus (HBV)
- Treatment with systemic immunostimulatory agents
- Treatment with systemic immunosuppressive medication
- History of severe allergic anaphylactic reactions to chimeric or humanized antibodies or fusion proteins
- Pregnancy or breastfeeding, or intention of becoming pregnant during study treatment or within 5 months after the last dose of study treatment
- Patients who have received a non-FDA or non-EMA approved anti-EGFR agent or any other non-FDA or non-EMA, approved agent as part of definitive local therapy, unless the unapproved agent was given in addition to an approved agent
- Any systemic therapies after permitted definitive local therapies
Studien-RationalePrimary outcome:
1. Independent Review Facility assessed Event Free Survival (IRF assessed EFS) (Time Frame - Randomization to the first documented disease recurrence, or disease progression (per Response Evaluation Criteria In Solid Tumors (RECIST v1.1)), or death from any cause, whichever occurs first, through the end of study (approximately 65 months))
2. Overall Survival (OS) after Randomization (Time Frame - Randomization to death from any cause, through the end of study (approximately 65 months))
Secondary outcome:
1. Investigator Assessed Event Free Survival (EFS) (Time Frame - Randomization to the first documented disease recurrence, or disease progression (per RECIST v1.1) or death from any cause, whichever occurs first, through the end of study (approximately 65 months))
2. Percentage of Participants with Adverse Events (Time Frame - Baseline until up to 90 days after end of treatment (approximately 65 months))
3. Serum Concentration of Atezolizumab (Time Frame - At pre-defined intervals from Cycle 1, Day 1, through end of treatment (approximately 1 year).)
4. Change from baseline in physical function and Quality of Life Global Health Status/Quality of Life Scales of the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (Time Frame - Baseline up until 30 days from last dose (approximately 65 months overall))
Studien-Arme
Active Comparator: AtezolizumabParticipants will receive Atezolizumab for 16 cycles, or up to 1 year (whichever occurs first)Experimental: PlaceboParticipants will receive Placebo for 16 cycles, or up to 1 year (whichever occurs first).
Geprüfte Regime
Atezolizumab:Atezolizumab intravenous infusion will be administered at a fixed dose on Day 1 of each 21-day cycle for 16 cycles.Placebo:Placebo intravenous infusion will be administered a fixed dose on Day 1 of each 21-day cycle for 16 cycles.
StudienleiterClinical TrialsStudy DirectorHoffmann-La Roche
KontaktReference Study ID Number: WO40242 www.roche.com/about_roche/roche_worldwide.htmKontakt:Phone: 888-662-6728 (U.S. and Canada)E-Mail: [email protected]
Studienlocations (3 von 188)Southern Cancer Center36526 DaphneUnited States
Status: Rekrutierend
University of Arizona85724-5030 TucsonUnited States
Status: Noch nicht rekrutierend
Kaiser Permanente - Bellflower90706 BellflowerUnited States
Status: Rekrutierend
City of Hope National Medical Center91010 DuarteUnited States
Status: Rekrutierend
University of California San Diego Medical Center; Moores Cancer Center92093 La JollaUnited States
Status: Rekrutierend
University of Oklahoma90033 Los AngelesUnited States
Status: Noch nicht rekrutierend
UCLA Hematology/Oncology90404 Santa MonicaUnited States
Status: Aktiv, nicht rekrutierend
Kaiser Permanente - Vallejo94589 VallejoUnited States
Status: Rekrutierend
Rocky Mountain Regional VA Medical Center80045 AuroraUnited States
Status: Rekrutierend
Georgetown U; Lombardi Comp Can
20016-1468 WashingtonUnited States
Status: Noch nicht rekrutierend
Johns Hopkins Sidney Kimmel Cancer Center at Sibley Memorial Hospital20016 WashingtonUnited States
Status: Zurückgezogen
Miami Cancer Institute of Baptist Health, Inc.33176 MiamiUnited States
Status: Rekrutierend
Woodlands Medical Specialists, P.A.32503 PensacolaUnited States
Status: Rekrutierend
Winship Cancer Institute of Emory University30329 AtlantaUnited States
Status: Rekrutierend
Northwest Georgia Oncology Centers30060 MariettaUnited States
Status: Rekrutierend
Northwestern Medical Group/Northwestern University60611 ChicagoUnited States
Status: Noch nicht rekrutierend
Illinois Cancer Care61615 Peoria
United States
Status: Rekrutierend
Cancer Center of Kansas67214-3728 WichitaUnited States
Status: Aktiv, nicht rekrutierend
Maryland Oncology Hematology Columbia - USOR21044 ColumbiaUnited States
Status: Rekrutierend
Dana-Farber Cancer Institute02215 BostonUnited States
Status: Rekrutierend
Henry Ford Health System48202 DetroitUnited States
Status: Noch nicht rekrutierend
Billings Clinic Research Center59101 BillingsUnited States
Status: Rekrutierend
Morristown Medical Center07962 MorristownUnited States
Status: Noch nicht rekrutierend
New York Oncology Hematology,P.C.-Albany12208 AlbanyUnited States
Status: Rekrutierend
Cleveland Clinic; Taussig Cancer Institute44195 ClevelandUnited States
Status: Aktiv, nicht rekrutierend
OSU, James Cancer Hospital43210 ColumbusUnited States
Status: Noch nicht rekrutierend
Fox Chase Cancer Center; Hematology/Oncology19111 PhiladelphiaUnited States
Status: Rekrutierend
Blue Ridge Cancer Care24014 RoanokeUnited States
Status: Rekrutierend
Northwest Cancer Specialists - Vancouver98684 VancouverUnited States
Status: Abgebrochen
St George Hospital2217 KogarahAustralia
Status: Rekrutierend
Adelaide Cancer Centre5037 Kurralta ParkAustralia
Status: Rekrutierend
Peter MacCallum Cancer Center3000 MelbourneAustralia
Status: Rekrutierend
Sir Charles Gairdner Hospital6009 NedlandsAustralia
Status: Rekrutierend
GHdC Site Notre Dame6000 CharleroiBelgium
Status: Rekrutierend
UZ Antwerpen2650 EdegemBelgium
Status: Rekrutierend
Clinique Ste-Elisabeth5000 NamurBelgium
Status: Rekrutierend
Santa Casa de Misericordia de Salvador; Oncologia40050-410 SalvadorBrazil
Status: Rekrutierend
Hospital do Cancer de Pernambuco - HCP50040-000 RecifeBrazil
Status: Rekrutierend
Instituto Nacional do Cancer - INCA
20560-120 Rio de JaneiroBrazil
Status: Rekrutierend
Hospital Sao Lucas - PUCRS90610-000 Porto AlegreBrazil
Status: Rekrutierend
Hospital Nossa Senhora da Conceicao91350-200 Porto AlegreBrazil
Status: Rekrutierend
CEPHO - Centro de Estudos e Pesquisas em Hematologia e Oncologia09060-650 Santo AndréBrazil
Status: Rekrutierend
Instituto do Cancer do Estado de Sao Paulo - ICESP01246-000 Sao PauloBrazil
Status: Rekrutierend
Cross Cancer InstituteT6G 1Z2 EdmontonCanada
Status: Aktiv, nicht rekrutierend
Fraser Valley Centre British Columbia Cancer AgencyV3V 1Z2 SurreyCanada
Status: Rekrutierend
Cancer Care ManitobaR3E 0V9 Winnipeg
Canada
Status: Rekrutierend
London Health Sciences CentreN6A 4L6 LondonCanada
Status: Rekrutierend
Beijing Cancer Hospital100142 BeijingChina
Status: Rekrutierend
Xiangya Hospital of Centre-South University410008 ChangshaChina
Status: Noch nicht rekrutierend
West China Hospital, Sichuan University610041 ChengduChina
Status: Rekrutierend
Fujian Cancer Hospital350014 FuzhouChina
Status: Rekrutierend
The Second Affiliated Hospital of Zhejiang University School of Medicine310009 Hangzhou CityChina
Status: Rekrutierend
Zhejiang Cancer Hospital310022 HangzhouChina
Status: Rekrutierend
Harbin Medical University Cancer Hospital150081 HarbinChina
Status: Noch nicht rekrutierend
Jiangxi Cancer Hospital; First department of abdominal surgery330029 NanchangChina
Status: Noch nicht rekrutierend
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine200011 ShanghaiChina
Status: Rekrutierend
Fudan University Shanghai Cancer Center200032 ShanghaiChina
Status: Rekrutierend
Shanghai East HospitalShanghaiChina
Status: Rekrutierend
Tianjin Medical University General Hospital300052 Tianjin (天津)China
Status: Rekrutierend
Union Hospital Tongji Medical College Huazhong University of Science and Technology430023 Wuhan CityChina
Status: Rekrutierend
Institut Sainte Catherine84918 AvignonFrance
Status: Rekrutierend
Centre Georges Francois Leclerc21000 DijonFrance
Status: Rekrutierend
CENTRE LEON BERARD; Département d'Hématologie et d'Oncologie69373 LyonFrance
Status: Aktiv, nicht rekrutierend
Hopital Timone Adultes; Oncologie Medicale Et Usp13385 MarseilleFrance
Status: Rekrutierend
ICM; Radiotherapie34298 Montpellier Cedex 5France
Status: Rekrutierend
Hopital Tenon; Oncologie Radiotherapie75970 ParisFrance
Status: Rekrutierend
CHU Bordeaux33604 PessacFrance
Status: Rekrutierend
Hôpitaux D'Instruction Des Armees Begin94160 St MandeFrance
Status: Rekrutierend
Gustave Roussy Cancer Campus; Radiotherapie94805 VILLEJUIF CedexFrance
Status: Rekrutierend
Charité - Campus Benjamin Franklin; Innere Medizin, Haematologie/Onkologie12203 Berlin(Berlin)Germany
Status: Noch nicht rekrutierend
Universitätsklinikum Bonn; Med. Klinik und Poliklinik III; Hämatologie, Onkologie und Rheumatologie53127 Bonn(Nordrhein-Westfalen)Germany
Status: Rekrutierend
Universitätsklinikum Freiburg, Klinik für Strahlenheilkunde79106 Freiburg(Baden-Württemberg)Germany
Status: Rekrutierend
Universitätsklinikum Schleswig-Holstein; Klinik F. Strahlentherapie24105 Kiel(Schleswig-Holstein)Germany
Status: Rekrutierend
Klinikum d. Uni. München; Campus Großhadern; Klinik und Poliklinik f. Strahlenthera. und Radioonko
81377 München(Bayern)Germany
Status: Rekrutierend
Universitätsmedizin Rostock, Klinik und Poliklinik für Strahlentherapie; Zentrum für Radiologie18059 Rostock(Mecklenburg-Vorpommern)Germany
Status: Rekrutierend
Orszagos Onkologial Intezet; Onkologiai Osztaly X1122 BudapestHungary
Status: Rekrutierend
Uzsoki Utcai Korhaz1145 BudapestHungary
Status: Rekrutierend
Pécsi Tudományegyetem; Klinikai Központ Onkoterápiás Intézet7624 PecsHungary
Status: Rekrutierend
Rajiv Gandhi Cancer Institute & Research Center110085 New DelhiIndia
Status: Rekrutierend
Medanta-The Medicity122001 GurgaonIndia
Status: Rekrutierend
Tata Memorial Hospital; Dept of Medical Oncology400012 MumbaiIndia
Status: Aktiv, nicht rekrutierend
Max Super Speciality Hospital110017 New DelhiIndia
Status: Rekrutierend
Istituto Nazionale Tumori Fondazione G. Pascale; S.C. Oncol. Medica Testa-Collo e Sarcoma80131 NapoliItaly
Status: Rekrutierend
Ospedale Umberto I ASL di Ravenna Presidio Ospedaliero di LugoLugoItaly
Status: Noch nicht rekrutierend
IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica47014 MeldolaItaly
Status: Noch nicht rekrutierend
Policlinico Umberto i di Roma; dip. Scienze Radiologiche, Oncologiche, Anatomopatologiche00161 RomaItaly
Status: Noch nicht rekrutierend
Ospedale Civile; Servizio Oncologia17100 SavonaItaly
Status: Rekrutierend
Spedali Civili di Brescia25123 BresciaItaly
Status: Rekrutierend
Fondazione IRCCS Istituto Nazionale dei Tumori;S.S. Trattamento MedicoTumori dellaTesta e delCollo20133 MilanoItaly
Status: Rekrutierend
Asst Santi Paolo E Carlo; Unita Operativa Di Oncologia Medica20142 MilanoItaly
Status: Rekrutierend
Istituto Clinico Humanitas;U.O. Oncologia Medica Ed Ematologia20089 RozzanoItaly
Status: Noch nicht rekrutierend
Azienda Ospedaliero-Universitaria Careggi; SOD Radioterapia50134 FirenzeItaly
Status: Rekrutierend
IOV - Istituto Oncologico Veneto IRCCS35128 PadovaItaly
Status: Rekrutierend
Aichi Cancer Center Hospital464-8681 AichiJapan
Status: Aktiv, nicht rekrutierend
National Cancer Center Hospital East
277-8577 ChibaJapan
Status: Aktiv, nicht rekrutierend
National Hospital Organization Kyushu Cancer Center811-1395 FukuokaJapan
Status: Aktiv, nicht rekrutierend
Hokkaido University Hospital060-8648 HokkaidoJapan
Status: Rekrutierend
Kobe University Hospital650-0017 HyogoJapan
Status: Aktiv, nicht rekrutierend
Miyagi Cancer Center981-1293 MiyagiJapan
Status: Rekrutierend
Okayama University Hospital700-8558 OkayamaJapan
Status: Rekrutierend
Osaka International Cancer Institute541-8567 OsakaJapan
Status: Rekrutierend
Shizuoka Cancer Center41109340 Shizuoka
Japan
Status: Rekrutierend
National Cancer Center Hospital104-0045 TokyoJapan
Status: Rekrutierend
The Jikei University Hospital105-8471 TokyoJapan
Status: Rekrutierend
Tokyo Medical & Dental University Hospital113-8519 TokyoJapan
Status: Rekrutierend
The Cancer Institute Hospital of JFCR135-8550 TokyoJapan
Status: Rekrutierend
Tokyo Medical University Hospital160-0023 TokyoJapan
Status: Aktiv, nicht rekrutierend
Seoul National University Bundang Hospital13620 Gyeonggi-doKorea, Republic of
Status: Rekrutierend
Seoul National University Hospital03080 SeoulKorea, Republic of
Status: Rekrutierend
Asan Medical Center - Oncology05505 SeoulKorea, Republic of
Status: Rekrutierend
Samsung Medical Center6351 SeoulKorea, Republic of
Status: Rekrutierend
Uniwersyteckie Centrum Kliniczne; Klinika Onkologii i Radioterapii80-214 GdańskPoland
Status: Rekrutierend
Centrum Onkologii-Instytut Im. Marii Skłodowskiej Curie; I Klinika Radioterapii i Chemioterapii44-101 GliwicePoland
Status: Rekrutierend
COZL Oddzial Onkologii Klinicznej z pododdzialem Chemioterapii Dziennej20-090 LublinPoland
Status: Zurückgezogen
Szpital Kliniczny im. Heliodora Święcickiego UM w Poznaniu.60-780 PoznańPoland
Status: Rekrutierend
Centrum Onkologii-Instytut Im. Marii Skłodowskiej Curie; Klinika Nowotworów Głowy i Szyi02-781 WarszawaPoland
Status: Rekrutierend
IPO de Coimbra; Servico de Oncologia Medica3000-075 CoimbraPortugal
Status: Rekrutierend
Hospital de Santa Maria; Servico de Oncologia Medica1649-035 LisboaPortugal
Status: Rekrutierend
IPO do Porto; Servico de Oncologia Medica4200-072 PortoPortugal
Status: Rekrutierend
FSBI"National Medical Research Center of Oncology named after N.N.Petrov" MHRF197758 St PetersburgRussian Federation
Status: Abgebrochen
First MSMU n.a. Sechenov Univercity Hospital 1; Plastic surgery119435 MoskvaRussian Federation
Status: Rekrutierend
FSAI Treatment and rehabilitation Centre Ministry of Health; Clinical research and chemotherapy.125367 MoskvaRussian Federation
Status: Rekrutierend
Arkhangelsk Regional Clinical Oncology Dispensary163045 ArkhangelskRussian Federation
Status: Abgebrochen
Sverdlovsk Regional Oncology Dispensary; Chemotherapy620905 EkaterinburgRussian Federation
Status: Rekrutierend
Ivanovo Regional Oncology Dispensary; Chemotherapy Department153013 IvanovoRussian Federation
Status: Abgebrochen
Krasnodar City Oncology Center350040 KrasnodarRussian Federation
Status: Rekrutierend
Krasnoyarsk Regional Oncology Dispensary n.a. Krizhanovsky; Chemotherapy660133 KrasnoyarskRussian Federation
Status: Rekrutierend
Main Military Clinical Hospital named after N.N. Burdenko105229 MoscowRussian Federation
Status: Rekrutierend
P.A. Herzen Oncological Inst. ; Oncology125284 MoscowRussian Federation
Status: Rekrutierend
Moscow city oncology hospital #62 of Moscow Healthcare Department
143423 MoscowRussian Federation
Status: Aktiv, nicht rekrutierend
City Oncology Hospital; Chemotherapy Dept603000 Nizhny NovgorodRussian Federation
Status: Zurückgezogen
Novosibirsk Regional Oncological Dispancer630108 NovosibirskRussian Federation
Status: Rekrutierend
BHI of Omsk region Clinical Oncology Dispensary644013 OmskRussian Federation
Status: Aktiv, nicht rekrutierend
S-Pb clinical scientific practical center of specialized kinds of medical care (oncological)197758 Saint-PetersburgRussian Federation
Status: Rekrutierend
Tomsk scientific research institute of oncology SO RAMN, PAD; Pathological634050 TomskRussian Federation
Status: Rekrutierend
Universitas Annex, University of the Free State; Clinical Oncology9300 BloemfonteinSouth Africa
Status: Rekrutierend
Groote Schuur Hospital ( Uni of Capetown ); Oncology Dept
7506 Cape TownSouth Africa
Status: Rekrutierend
Tygerberg Hospital; Oncology Dept7530 Cape TownSouth Africa
Status: Noch nicht rekrutierend
Cape Town Oncology Trials7570 Cape TownSouth Africa
Status: Rekrutierend
GVI Rondebosch Oncology Centre7700 Cape TownSouth Africa
Status: Noch nicht rekrutierend
GVI Oncology Outeniqua Unit; GVI Oncology Outeniqua Unit6530 GeorgeSouth Africa
Status: Rekrutierend
Wits Clinical Research; Charlotte Maxeke Johannesburg Academic Hospital2193 JohannesburgSouth Africa
Status: Rekrutierend
The Oncology Centre; Haematology - Radiation Oncology4001 MayvilleSouth Africa
Status: Rekrutierend
Langenhoven Drive Oncology Centre6045 Port Elizabeth
South Africa
Status: Rekrutierend
Steve Biko Academic Hospital; Oncology0002 PretoriaSouth Africa
Status: Rekrutierend
Sandton Oncology Medical Group2196 SandtonSouth Africa
Status: Rekrutierend
Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia08916 BadalonaSpain
Status: Rekrutierend
Insititut Catala D'Oncologia08908 Hospitalet de LlobregatSpain
Status: Aktiv, nicht rekrutierend
Hospital Clínic i Provincial; Servicio de Hematología y Oncología08036 BarcelonaSpain
Status: Aktiv, nicht rekrutierend
Hospital General Universitario Gregorio Marañon; Servicio de Oncologia28007 MadridSpain
Status: Rekrutierend
Hospital Universitario Clínico San Carlos; Servicio de Oncologia28040 MadridSpain
Status: Aktiv, nicht rekrutierend
Hospital Universitario 12 de Octubre; Servicio de Oncologia28041 MadridSpain
Status: Aktiv, nicht rekrutierend
Hospital Clinico Universitario de Salamanca; Servicio de Oncologia37007 SalamancaSpain
Status: Aktiv, nicht rekrutierend
Hospital Univ. Nuestra Señora de Valme; Servicio de Oncologia41014 SevillaSpain
Status: Rekrutierend
Hospital Universitario la Fe; Servicio de Oncologia46026 ValenciaSpain
Status: Aktiv, nicht rekrutierend
Hosp Clinico Univ Lozano Blesa50009 ZaragozaSpain
Status: Rekrutierend
China Medical University Hospital;Oncology and Hematology Office Critical Care Center, 14H404 TaichungTaiwan
Status: Aktiv, nicht rekrutierend
Taichung Veterans General Hospital; Radiation OncologyTaichungTaiwan
Status: Rekrutierend
National Cheng Kung Unversity Hospital; Oncology00704 TainanTaiwan
Status: Rekrutierend
Division of Hematology and Oncology, Taipei Veterans General Hospital112 TaipeiTaiwan
Status: Rekrutierend
National Taiwan University Hospital; OncologyTaipeiTaiwan
Status: Rekrutierend
Ramathibodi Hospital; Dept of Med.-Div. of Med. Onc10400 BangkokThailand
Status: Rekrutierend
Faculty of Med. Siriraj Hosp.; Med.-Div. of Med. Oncology10700 BangkokThailand
Status: Rekrutierend
Songklanagarind Hospital; Department of Oncology90110 SongkhlaThailand
Status: Aktiv, nicht rekrutierend
Adana Baskent University Hospital; Medical Oncology
01120 AdanaTurkey
Status: Rekrutierend
Hacettepe Universitesi Tip Fakultesi Hastanesi; Ic Hastaliklari Anabiim Dali06100 AnkaraTurkey
Status: Rekrutierend
Dr. Abdurrahman Yurtarslan Oncology Hospital; 2nd Oncology Clinic06200 AnkaraTurkey
Status: Rekrutierend
Gazi University Medical Faculty, Oncology Hospital06500 AnkaraTurkey
Status: Rekrutierend
Medikal Park Izmir Hospital35575 KarşıyakaTurkey
Status: Rekrutierend
Municipal Noncommercial Institution Regional Center of Oncology61070 KharkivUkraine
Status: Aktiv, nicht rekrutierend
Medical Center "Adonis" LLC08112 Kapitanovka VillageUkraine
Status: Zurückgezogen
Vinnytsya Regional Clinical Oncology Dispensary21029 Vinnytsya
Ukraine
Status: Rekrutierend
Medical Center ONCOLIFE69059 ZaporizhzhiaUkraine
Status: Rekrutierend
CI Dnipropetrovsk CMCH #4 of Dnipropetrovsk RC SI Dnipropetrovsk MA of MOHU Ch of Oncology and MR49102 DnipropetrovskUkraine
Status: Abgebrochen
Ivano-Frankivsk Regional Oncology Center76018 Ivano-FrankivskUkraine
Status: Rekrutierend
SI Institute of Medical Radiology n.a. S.P. Hryhoriev of NAMS of Ukraine61024 KharkivUkraine
Status: Zurückgezogen
Kyiv City Clinical Oncological Center, Day Hospital Department for Oncological patients03115 KievUkraine
Status: Aktiv, nicht rekrutierend
MI Kryvyi Rih Oncology Dispensary of Dnipropetrovsk Regional Council; Chemotherapy Department50048 Kryvyi RihUkraine
Status: Rekrutierend
Lviv State Oncology Regional Treatment and Diagnostic Centre; Department of
hemotherapy79031 LvivUkraine
Status: Rekrutierend
RCI Sumy Regional Clinical Oncological Dispensary40005 SumyUkraine
Status: Aktiv, nicht rekrutierend
Aberdeen Royal Infirmary; Medical Oncology DeptAB25 2ZN AberdeenUnited Kingdom
Status: Rekrutierend
Queen Elizabeth HospitalB15 2TH BirminghamUnited Kingdom
Status: Zurückgezogen
Velindre Cancer CentreCF14 2TL CardiffUnited Kingdom
Status: Rekrutierend
The Royal Marsden Hospital, FulhamSW3 6JJ LondonUnited Kingdom
Status: Rekrutierend
The Christie NHS Foundation TrustM20 4BX ManchesterUnited Kingdom
Status: Rekrutierend
Churchill Hospital; Oxford Cancer and Haematology Centre
OX3 7LJ OxfordUnited Kingdom
Status: Rekrutierend
Derriford HospitalPL6 8DH PlymouthUnited Kingdom
Status: Rekrutierend
Royal Marsden NHS Foundation TrustSM2 5PT SuttonUnited Kingdom
Status: Rekrutierend
Quelle: ClinicalTrials.gov