A role for neural crest in heart formation

Prenatal circulation

Post-natal circulation

Atrial SeptalDefects

Patent foramen ovale

Patent foramen ovale Patent foramen ovale

Patent foramen ovale

Sinus venosus ASDPrimum-type ASD

Heart tubeLoopingDefect

Tetralogy of Fallot Syndrome

MEDI 510 (IBS 518) July 24 - August 7, 2006

Human Embryology: Development and Disease

Charles Saxe, Ph.D., Course Director

Text: Moore, K.W., The Developing Human, W.B. Saunders Co., 7th ed., 2003 Place: Week 1: lectures and clinical correlations will be in Whitehead Auditorium Week 2: lectures and clinical correlations will be in the WHSCAB Auditorium Exams: all exams will be in the WHSCAB Auditorium Day Date Time Event Speaker Title Mon 7/24 9:00a Lect 1 Dr. Saxe Basic mechanisms of differentiation

11:00 Lect 2 Dr. Saxe Morphogenesis and cell interactions 11:45p Corr K. Torrente Intro to information retrieval at Emory

Tues 7/25 9:00 Lect 3 Dr. Saxe Principles of teratogenesis 11:00 Lect 4 Dr. Saxe Gametogenesis and fertilization 1:00p Clin Corr Dr. Mitchell Advances in invitro fertilization Wed 7/26 9:00 Clin Corr Ms Kinlaw Neonatal ethics

10:30 Lect 5 Dr. Saxe Extra-embryonic membranes; placenta 1:00p Lect 6 Dr. Saxe Urogenital system I. Gonads

Thur 7/27 9:00 Lect 7 Dr. Saxe Urogenital system II. Renal development 11:00 Clin Corr Dr. Smith Anomalies of the urinary tracts

Fri 7/28 9:00 Lect 8 Dr. Moberg Ectoderm - neurulation; CNS formation 10:45 Clin Corr Dr. Sladky Congenital Neural defects

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Mon 7/31 9:00 MIDTERM (1 hr)

Tues 8/1 9:00 Lect 9 Dr. Saxe Cardiovasc I. Heart,CV system Septation

10:30 Lect 10 Dr. Saxe Cardiovasc II. Congenital heart defects 11:30 Clin Corr Dr.Sutherland Common congenital heart defects Wed 8/2 9:00 Lect 11 Dr. Saxe Mesoderm I. limb and muscle; mitotic mechanisms 10:30 Lect 12 Dr. Saxe Mesoderm II. Limb and skeletal formation 1:00p Clin Corr Dr. Weil Congenital limb anomalies Thur 8/3 9:00 Lect 13 Dr. Saxe Endoderm I. Respiratory system 10:30 Lect 14 Dr. Saxe Endoderm II. Gut, Liver, Pancreas 1:00p Clin Corr Drs Nasr and Anomalies of the gut Williams

Fri 8/4 9:00 Lect 15 Dr. Saxe Cancer: Developmental mechanisms in oncogenesis

Mon 8/7 9:00 FINAL EXAM (2 hr)