A Revolutionary Approach to Clear Heavy Metals & ToxinsAll of us are carrying around a LIFETIME of accumulated TOXINS!!!There is now a simple, scientific and very effective means for substantially reducing your risk of Toxic Induced Chronic Degenerative Diseases!!!

Abnormal pregnancy outcomes Atherosclerosis Broad mood swings Cancer Chronic fatigue syndrome Chronic immune system depression Contact dermatitis Fatigue Fertility problems Fibromyalgia Headaches History of increasing sensitivity to exogenous exposures, odors,or medications Joint pain Kidney dysfunction Learning disorders Memory loss Mineral imbalances (particularly zinc and calcium) Multiple chemical sensitivities Muscle pain and weakness Nonresponsive or recurrent yeast infections Panic attacks Parkinson's disease Tinnitus Unusual responses to medications or supplementsWorsening of symptoms after anesthesia or pregnancyA growing body of literature suggests an association betweentoxicant exposure and the etiology of a number of chronicConditions. The Role of Detoxification in the Prevention of Chronic Degenerative Diseases BY DEANN J. LISKA, PH.D.of Chronic Degenerative DiseasesBY DEANN J. LISKA, PH.D.

TOXIC EFFECTS OF GENETICALLY MODIFIED ORGANISMSGMO OR GM FOOD

We are confronted with what is undoubtedly the single most potent technology the world has ever known - more powerful even than atomic energy. Yet it is being released throughout our environment and deployed with superficial or no risk assessments - as if no one needs to worry an iota about its unparalleled powers to harm life as we know it - and for all future generations. Nathan Batalion, ND www.rawwisdom.com/genetically%20modified%20food

statins are nothing more than isolated poisons derived from the fungus known as red yeast rice Nowhere in theHistory of man has anacknowledged poisonbeen touted as a dailyvitamin for every manwoman and child.

Reuter Health News Wednesday,May 23, 2007

Non- GMP certified supplements can be toxic!!!Of the 21 brands of multivitamins on the market in the US and Canada, selected by ConsumerLab.com and tested by by independent laboratories, just 10 met the stated claims on their labels or satisfied other quality standards. In the report, test showed that the Vitamin Shoope womens product conatined 15.3 micrograms of lead per daily serving of two daily tablets. This amount of lead is more than 10 times the amount permitted wothout a warning in California. www.msnbc.msn.com/id/16655168/below

WebMD with AOL HealthIn a study of newborn blood released by the Environmental Working group, an average of 200 industrial chemicals and pollutants were found in umbilical cord...Eighteen different forms of dioxin were also found in the sampleswww.my.webmd.com/content/article/10/8/109035.htm

Scientist have found TOXIC compounds planet wide, in polar bears in the Artic, cormorants in England and killer whales in the Pacific.

Dangers of Visceral Adipose Tissue Belly FatFat is a major source of silent inflammation. It is a toxic waste dump full of Arachidonic Acid and Toxins. Barry Sears, Ph.D.

Research published in the International Journal of Obesity indicates that liver toxicity can often lead to excess body fat accumulation, and moderately obese people frequently suffer from liver dysfunctionDue to theoverwhelming evidencelinking excess body fat to an overstressed livercleansing and supporting yourliver may be yourticket to a healthiermetabolism.Brad J. King, MS, MFS, is a nutritional researcher and author

Continuous exposure to dietary and environmental toxins may lead to an impairment in the ability of patients to metabolize and clear damage causing compounds from their bodyToxins from the environment and diet usually can lead bodily stress and dis-ease

Exposure to heavy metal toxicants is almost unavoidable in todays world

Elevated toxic burden is related to a number of different chronic conditions There were striking dose-response relations between serum concentrations of six selected POPs (persistent organic pollutants) and the prevalence of type 2 diabetes. The strong association could offer a compelling challenge to future toxicological studies.

Diabetes Care 2006; 29: 1638-43.

PCB production was banned in the 1970s due to the high toxicity of most PCB congeners and mixtures. PCBs are classified as persistent organic pollutants which bioaccumulate in animals.Many POPs are currently or were in the past used as pesticides. Others are used in industrial processes and in the production of a range of goods such as solvents, polyvinyl chloride, and pharmaceuticals.[1]

Elevated toxic metal burden affects all organ systems Toxicity, Heavy MetalsSoghoian S, MD, et alDepartment of Emergency Medicine, State University of New York Downstate Medical Center

Background: Heavy metal toxicity represents an uncommon, yet clinically significant, medical condition. If unrecognized or inappropriately treated, heavy metal toxicity can result in significant morbidity and mortality. The periodic table contains 105 elements, of which 80 are considered metals. Toxic effects in humans have been described for less than 30 of these. Many metals are essential to biochemical processes, and others have found therapeutic uses in medicine. Iatrogenic metal toxicity may occur with bismuth, gold, gallium, lithium, and aluminum species. Intentional or unintentional ingestion of arsenic has been notorious as a means of suicide and homicide. However, occupational exposure to heavy metals has accounted for the vast majority of poisonings throughout human history. Hippocrates described abdominal colic in a man who extracted metals, and the pernicious effects of arsenic and mercury among smelters were known even to Theophrastus of Erebus (370-287 BC). The classic acute occupational heavy metal toxicity is metal fume fever (MFF), a self-limiting inhalation syndrome seen in workers exposed to metal oxide fumes. MFF, or brass founders ague, zinc shakes, Monday morning fever as it is variously known, is characterized by fever, headache, fatigue, dyspnea, cough, and a metallic taste occurring within 3-10 hours after exposure. The usual culprit is zinc oxide, but MFF may occur with magnesium, cobalt, and copper oxide fumes as well. A neutrophil alveolitis ensues, with hypoxia, reduced vital capacity, and diffuse bilateral infiltrates seen on radiographs. The pathophysiology of MFF appears to be a direct toxic irritation. Treatment is supportive and effects generally resolve within 24 hours. The diagnosis of MFF is based on a history of exposure and must be clearly differentiated from the true chemical pneumonitis that occurs after exposure to metal fumes from cadmium, manganese, mercury, and nickel. These exposures are clinically indistinguishable from MFF in the early stages but tend to progress to ARDS and cause significantly more morbidity and mortality. Toxic effects from chronic exposure to heavy metals are far more common than acute poisonings. Chronic exposure may lead to a variety of conditions depending on the route of exposure and the metabolism and storage of the specific element in question. For example, chronic exposure to cobalt dust has been associated with the development of pulmonary fibrosis that can lead to cor pulmonale. This hard metal pneumoconiosis has been described for other metal dusts. Chronic inhalation of high levels of cadmium also causes both fibrotic and emphysematous lung damage, but it also has major effects in bone andhttp://www.emedicine.com/EMERG/topic237.htm Nearly all organ systems are involved in heavy metal toxicity; however, the most commonly involved organ systems include the central nervous system, peripheral nervous system, gastrointestinal, hematopoietic, renal, and cardiovascular.

How do you recognize the symptoms of elevated toxicity in your body? Some EARLY warning signs are:

Generalized muscle aches

Chronic fatigue

Fibromyalgia

Food allergies or chemical sensitivities

Additional indications that may be linked to elevated heavy metal burdenSome EARLY warning signs of heavy metal toxicity are:

Difficulty concentrating, irritability, headache Lethargy, fatigue, weakness (#1 physical complaint)Abdominal pain, tremors, Kidney distress, elevated liver enzymes

Simple diagnostics to evaluate toxicity in our patients

Detoxification Questionnaire Bio Impedance Analysis (Phase Angle and ICW Vs. ECW) Urinary pH testing Hair analysisSimple in-office surveys and tools that help us help identify patients in need

Detoxification QuestionnaireQuantifies patient symptoms (MSQ)Identifies Toxicant Tolerability (XTT)Simple metric to track patient improvementUse the detoxification questionnaire to qualify your patients needs

Medical Symptoms Questionnaire (MSQ)Identifies symptoms in most body systemsQuantifies patients level of symptomsProvides a simple metric to track patient improvementUse the established MSQ to quantify symptoms

Increased urinary alkalinity has been associated with increased rates of toxin excretion

Screen patients that may need additional support to excrete toxinspH testing aids in identifying our patients that may benefit from increased urinary alkalinity

We always recommend alkalizing support for patients with urinary pH below 6.6

By far the majority of toxins and toxic drugs are lipid soluble: Therefore, to be efficiently and safely removed via urine must be converted to a non-toxic water-soluble molecule during metabolism

Liver - The Detox MachineFilters 2 quarts of blood every minuteRemoves and alters substancesPrepares them for elimination

Metabolic detoxification improves the process of biotransformation and an alkaline urinary pH supports clearance of toxinsSpecific nutrients are required to support all three phases of detoxificationPhase IIIncreased alkalinity supports excretionHelps to balance clearance enzymesPhase IIIPhase I

Phase IConjugationPhase I enzymes activate toxins in preparation for biotransformation Phase IIFunctionalizationToxinReactive IntermediaryCytochrome P450 enzymes add reactive functional groups to fat-soluble toxinsPhase IL-Cysteine, Magnesium and other nutrients support proper expression of Phase I CYP450 enzymes

Phase IConjugationPhase IIFunctionalizationReactive IntermediaryNeutralizedToxinThe functional groups are then reacted with conjugation molecules to neutralize the toxins and make them water solublePhase IIPhase II enzymes neutralize the activated toxin in preparation for elimination Glycine, taurine, sodium sulfate and glutathione precursors support the creation of Phase II enzymes

Phase IConjugationElimination of toxins is supported by an alkaline urinary pHPhase IIFunctionalizationNeutralizedToxinPotassium citrate increases urinary alkalinity which supports excretion of biotransformed toxinsNeutralizedToxinAlkaline urine supports excretionPhase III

Intravenous Chelation TherapyEDTATypically heavy metals and atherosclerosisHas not been shown effective in oral dosing

Side effects: Depletion of vitamins and minerals, including B vitamins, vitamin C, and magnesium.

Other side effects that have been reported include low blood sugar, diminished calcium levels, headache, nausea, dangerously low blood pressure, kidney failure, organ damage, irregular heartbeat, and seizures.There is a demonstrated need for a safer, more convenient method of removing heavy metals

One of the most important detoxification proteins in all speciesIn absence of heavy metals, its primary role is to transport zinc and copperProtection against and elimination of toxic metals by metallothionein is well-described in literature

MetallothioneinAndrews GK. Regulation of metallothionein gene expression by oxidative stress and metal ions. Biochem Pharmacol 2000;59(1):95-104. Lichtlen et al.. Bioessays. 2001;23(11):1010-7.A new approach: stimulate the bodys natural ability to remove heavy metals

Andrews GK. Regulation of metallothionein gene expression by oxidative stress and metal ions. Biochem Pharmacol 2000;59(1):95-104. Lichtlen et al.. Bioessays. 2001;23(11):1010-7.Known to efficiently bind several toxic metals (particularly Cadmium and Mercury) and act as a transporter of toxic metals to the liver or kidneys for conjugation and excretionPrevents reaction of toxic metals with other biomolecules, thus attenuating their toxicityMetallothioneinsNatural proteins designed to transport and eliminate metals from cellsSources of heavy metals include seafood, groundwater, smoking, dental amalgams, pesticides and industrial exposure

We can expect exceptional regenerative outcomes with a nutrigenomic approach A complete system for detoxificationMetabolismGene ExpressionCellular ExpressionSKRMS: Modulate cell signals(Indirect)(Direct)Diet & Medical FoodKey Nutritional Support for liver and kidneys

The excretion of toxic metals is governed by a complex chain of interwoven activities:Phytonutrients up-regulates expression of MTF-1 (Metal-activated transcription factor-1)MTF-1 induces creation of metallothionein (MT) in messenger RNAInduced metallothionein (MT) bind to metals within the cellOnce metal is mobilized by MT, it is transported through the cell membrane and transported to the liver for Phase II detoxification and excretion through urine or feces

A revolutionary mechanism for heavy metal detoxification

Study patients experienced a significant increase in the excretion of metalsIncrease over baselineElimination of arsenic increased 124%Elimination of lead increased 200%Metabolism of essential minerals was not significantly impacted in study patients* *manganese was the one exception, consider additional supplementation during program.All patients began with mercury levels below detectable limits Two patients experienced a significant increase in mercury excretionMercury Elimination Through Urine

Day 0Day 10Patients 1-3 dl > dl >Patient 4 dl >Significant IncreasePatients 5-8 dl > dl >Patient 9 dl >Significant Increase dl > = Below Detectable limit

Chart4

1.282.11.25531914891.90476190482.48421052631.08403361341.08888888890.16

Arsenic

Lead

Barium

Cadmium

Cobalt

Aluminum

Lithium

Molybdenum

Increase over Baseline

% Imrovement

Increase of Urine Excretion of Clinically Relevant Metals

Raw Data

TestAluminumAntimonyArsenicBariumBismuthCadmiumCalciumCesiumChromiumCobaltCopperCreatinineGadoliniumGalliumIronLeadLithiumMagnesiumManganeseMercuryMolybdenumNickelNiobiumPlatinumPotassiumRubidiumSeleniumStrontiumSulfurThalliumThoriumTinTungstenUraniumUrine TVUrineLofCollVanadiumZinc

Units0 - 22.30 - 0.1490 - 500 - 6.70 - 2.280 - 0.6437 - 3130 - 10.50.6 - 9.40.01 - 2.604.0 - 11.423.00 - 205.000 - 0.0190 - 0.0285 - 640 - 1.49 - 12941 - 2670.03 - 1.160 - 2.1915 - 1750 - 3.880 - 0.0840 - 0.033759 - 46530 - 226332 - 33347 - 346367 - 13280 - 0.2980 - 4.1890 - 2.040 - 0.2110 - 0.0260.1 - 3.263 - 688

Ref Rangeug/g creatug/g creatug/g creatug/g creatug/g creatug/g creatug/g creatug/g creatug/g creatug/g creatmg/dLug/g creatug/g creatug/g creatug/g creatug/g creatug/g creatug/g creatug/g creatug/g creatug/g creatug/g creatug/g creatug/g creatug/g creatug/g creatug/g creatug/g creatug/g creatug/g creatug/g creatug/g creatug/g creatmLhourug/g creatug/g creat

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No significant side effects were seen in study patientsNo changes in basic labs including hematology, electrolytes, and liver and kidney function testsTwo subjects had minor symptoms:One subject with history of migraines experienced a migraine and GI upsetOne subject experienced mild headache

Conclusions from study and clinical guidelinesCombination of Polyphenol-rich hops, andrographis, curcumin and zincResulted in a significant increase in the expression of metallothioneinIncreases excretion of clinically relevant toxic metals (with minimal effect on nutrient compounds)

Research indicates this clinical breakthrough achieves dramatic resultsOther considerations: Can be used to compliment a comprehensive metabolic detoxification programSome patients may experience mild headacheAdditional manganese supplementation may be needed

Metagenics Functional Medicine Research Center dosage guidelines 3 tablets twice daily for 30 to 60 days

The Intestinal TractA Natural Barrier to Toxic Substances

Leaky Gut Syndrome - passage of toxic substances into the body

Strategies to Prevent Leaky GutBalance microflora (good bacteria) Limit use of NSAIDsEnlist nutritional supportMinimize use of alcohol, caffeine, processed foods and additivesManage stress

Promote Balanced MicrofloraProbioticsLactobacillus acidophilusBifidobacterium

PrebioticsFructooligosaccharides honey, onions, bananas, oats

Foods for DetoxificationCruciferous vegetablesBroccoli, cabbage, bok choy, arugula, cauliflower

Limonene-containing fruitsOrange, tangerine, lemon (not grapefruit)

Nutrients for DetoxificationMagnesiumCopperZincVitamin CVitamin B familyProtein

Core Protocols for Comprehensive DetoxificationMetabolic DetoxificationAlkalizing support for detoxification2 scoops twice daily as recommended in Quick Start guideChoose 10 or 28 day program based upon needSome people may need to be introduced to the Medical Food slowly

Heavy Metal DetoxificationPolyphenol-rich hops, Andrographis, Curcumin, Zinc3 tablets twice daily Continue therapy for 30 to 60 daysUse in conjunction with a comprehensive metabolic detoxification program, or as a stand-alone therapy

Research Summary

17 Years of clinical testing with tens of thousands of patientsPublished clinical studies demonstrating efficacy Numerous case studies establishing effectiveness in treating toxic-related symptoms Significant reduction in patient symptoms is typical Significant improvement in patients condition in just four weeksYou can expect increased NRG and a dramatic increase in health with a clinically proven approach to detoxificationCase Studies: MET1504, MET1505Fibromyalgia, Peripheral Neuropathy, and InsomniaFibromyalgia

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Hematopoietic stem cells (HSCs) are stem cells that give rise to all the blood cell types The liver is the primary detoxification organ in the body. It processes about 2 quarts of blood every minute, removing particles and preparing them for elimination. This makes the liver one of the hardest working organs in the body. You can say that the liver protects the rest of the body from harmful substances by reducing their toxicity and making them ready for excretion. Its a good idea to treat your liver well in order for it to keep you well. METALLOTHIONEIN. Metallothionein is a cysteine-based protein that transports metals such as copper, zinc, and cadmium in the body.Also used for AutisCd is CadmiumHg is mercuryMercury: Doctor what is amazing about this study is that these were individuals with below detectable levels of mercury in their urine. During the course of therapy, enough mercury was transferred out the cells that the urinary spill of mercury for two of the patients increased significantly above the detection threshold.

Same subject reported all those AEs Joe to check to see whether migraines pre-existingThe intestinal tract is another very important organ involved in preventing toxic overload. It acts as a natural barrier to substances that are not supposed to enter the circulation. If large particles are allowed to pass or leak into the general circulation, they can promote inflammation. Keeping the intestinal tract healthy is a good strategy to prevent leaky gut. The gastrointestinal tract is susceptible to damage in a variety of ways. Balancing the flora or good bacteria, limiting the use of non-steroidal anti-inflammatory drugs, providing nutritional support, minimizing the use of alcohol, caffeine, processed foods and food additives, as well as managing stress, are all ways to prevent leaky gut. Well be focusing mainly on balancing the microflora by using probiotics and fiber. There are hundreds of different species of microflora that live in our GI tracts. Overgrowth of one kind relative to another can lead to a variety health problems. One way to promote a healthy balance of intestinal tract microflora is to use probiotics and prebiotics. Probiotic means for life and is used to emphasize the healthy effects of friendly bacteria, such as Lactobacillus acidophilus and bifidobacteria. Taking antibiotic medications (anti-biotics means anti-life) can wipe out the good as well as the bad bacteria. Taking probiotics after a course of antibiotics can restore the friendly bacteria. Homemade yogurt, sauerkraut, and acidophilus milk will provide these probiotics. Or, you might want to take a dietary supplement, as food sources are not reliable sources of lactobacillus.Prebiotics refer to substances known as fructooligosaccharides, a complex molecule that is healthful to the gastrointestinal tract. You can get FOS from honey, onions, bananas, and oats to name a few foods. Two very important groups of fruits and vegetables for detoxification are the cruciferous vegetables and citrus fruits that contain limonene. Broccoli, cabbage, bok choy, arugula and cauliflower are part of the cruciferous vegetable family. They contain substances called indoles. These substances can reduce the toxicity of substances that might otherwise lead to cancer. Studies are showing that people that eat this group of vegetables regularly have fewer hormone-related cancers. The citrus fruits contain limonene, which we talked about in a previous session. Limonene supports the livers detoxification process. Try to get something from the citrus group every day. Grapefruit has a substance called naringenin that reduces the ability of the liver to detoxify certain drugs. Talk to your healthcare provider if you take medications and like to eat grapefruit. Naringenin may reduce the effectiveness of the medication. One way we can support the liver is to nourish it with these important vitamins and minerals. We talked about these in the last 2 sessions, and what foods provide good quantities of these. Eating healthy, fresh fruits and vegetables, good quality whole grains, legumes, and lowfat meat, poultry and fish provide these nutrients. Andrographis is a shrub found throughout India and other Asian countries that is sometimes called "Indian echinacea." may be better than milk thistle for liver detoxCurcumin is the principal curcuminoid of the popular Indian curry spice turmeric that is from the ginger family