A Patient’s Guide to Aesthetic Treatments€¦ · your specific needs, so the cost will vary from patient to patient • In general, the cost of a treatment is comparable to the

Restylane and Perlane are registered trademarks of HA North American Sales AB. © 2009 Medicis Aesthetics Inc. RES 09-106 10/30/10

See Important Safety Considerations on Slides 28-30

A Patient’s Guide to Aesthetic Treatments


What happens as we age?• Hyaluronic acid (HA) is a

naturally occurring substance in your skin that helps provide fullness and elasticity1

• As we age, skin loses HA1

• As HA diminishes, skin loses volume, increasing chances for wrinkles and folds to appear1

Line

Wrinkle

Fold

2

See Important Safety Considerations on Slides 28–30.

1. Wang F, Garza LA, Kang S, et al. In vivo stimulation of de novo collagen production caused by cross-linkedhyaluronic acid dermal filler injections in photodamaged human skin. Arch Dermatol. 2007;143:155-163.


What can be done?

• Either Restylane or Perlane can be used to restore volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as:- Nasolabial folds (NLF)

(nose-to-mouth lines)

- Oral commissures (corner-of-the-mouth lines)

- Marionette lines(mouth-to-chin lines)

- Perioral rhytides (smokers’ lines/lipstick lines)

3


Restylane and Perlane are registered trademarks of HA North American Sales AB. © 2009 Medicis Aesthetics Inc. RES 09-106 10/30/10 4

Considerations with dermal fillers• Natural-looking results• How long results last• Where they can be used• Cost to patients• Ease of use and reversibility• Allergy testing requirements• Short-term and long-term side effects



Restylane and Perlane: A family of products you can trust

• Restylane and Perlane have well-defined safety and effectiveness profiles

• Restylane is available in more than 70 countries and has been used in more than 10 million treatments worldwide*

• Clinical studies have shown no significant differences in the safety of Restylane and Perlane

• Restylane is the #1-selling dermal filler in the world• Restylane and Perlane are only available through a

licensed practitioner. Complete product and safety information is available at www.RestylaneUSA.com

* Includes Q‐Med AB HA products not available in the U.S.


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Restylane or Perlane: Well-established safety profiles

• Restylane and Perlane contain no animal proteins. This may limit the risk of animal-based disease transmission or allergic reactions– Both products contain trace amounts of gram-positive bacterial

proteins and are contraindicated for patients with a history of allergies to such material

– No allergy testing is required before use

• After your treatment with Restylane or Perlane, you may have some swelling, redness, pain, bruising, and tenderness that typically last less than seven days



Restylane lasts up to 18 months with one follow-up treatment

• Restylane has been studied as a single treatment in the lines from the nose to the corners of the mouth (nasolabial folds) with duration of effect lasting up to six months

• Restylane has also been studied as a two-stage treatment: Initial treatment, then a follow-up treatment at 4.5 or 9 months

• In a clinical study, at least 95% of patients treated with Restylane continued to see results for up to 18 months after initial treatment when patients returned for follow-up treatment at 4.5 or 9 months

• Work with your healthcare professional to maintain your results with regularly scheduled treatments



Trusted results for up to 18 months from baseline with one follow-up treatment

*Clinical Study Report. A Randomized, Evaluator-Blind, Multi-Center Comparison of the Efficacy and Persistence of Correction of Nasolabial Folds with Restylane Using Two Different Retreatment Schedules. Protocol # MA-04-003. June 3, 2008.

Average Improvement from Initial Treatment to 18 MonthsG

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The Restylane Regimen

• Helps ensure that you get the most from your Restylane treatments

• The same two-step treatment program studied in a clinical trial• At the time of your initial treatment, talk to your healthcare

professional about a follow-up treatment 4.5 or 9 months later

• Work with your healthcare professional to maintain a RestylaneRegimen that’s right for you



Perlane lasts at least six months with a single treatment

• Perlane has been studied only as a single treatment in the nasolabial folds (NLFs)

• In three clinical trials, patients were evaluated 6 months after initial treatment

• Up to 75% of patients maintained at least a one-grade improvement on a 5-grade scale at 6 months after initial treatment– 75% in a study of 150 patients– 71% in a study of 147 patients– 63% in a study of 138 patients



How does my healthcare professional know when to use Restylane or Perlane?

• Your healthcare professional will decide which product is right for you based on a personal evaluation

• Either Restylane or Perlane can be used to restore volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds). Ask your physician which is right for you– Restylane adds structural support and lift – Perlane is for deeper injection to add volume



How are Restylane and Perlane different from botulinum neurotoxins?

• Botulinum neurotoxins and Restylane or Perlane are used to correct different facial wrinkles and work in different ways– Restylane and Perlane are dermal fillers injected into

the skin, adding volume to smooth certain facial lines and wrinkles

– Botulinum toxin type A products are injected into the muscles between and above your eyebrows to prevent contraction of the muscles that cause frown lines



How much do Restylane and Perlanetreatments cost?

• Treatment with Restylane or Perlane is based on your specific needs, so the cost will vary from patient to patient

• In general, the cost of a treatment is comparable to the cost of similar dermal filler procedures

• Ask your healthcare professional to provide a cost estimate based on your needs



What should patients do prior to treatment?

• There are things you should do before being treated with Restylane or Perlane that may improve your experience and help reduce the risk of certain adverse events– Avoid using St. John’s Wort, high doses of

vitamin E supplements, aspirin, or nonsteroidal anti-inflammatory medications (e.g., ibuprofen) prior to treatment because these may increase bruising or bleeding at the injection site

– If you have previously suffered from facial cold sores, discuss this with your healthcare professional who may consider prescribing a medication to minimize recurrence



Treatment for achieving the look you desire• Restylane and Perlane are injected directly into the

skin in small amounts by an ultra fine needle • The procedure can usually be accomplished in just

one visit to the doctor's office with immediately visible results

• Your healthcare professional will help you decide if Restylane or Perlane is right for you



How much discomfort will I feel?• Some patients find facial injections more uncomfortable

than others• To increase your comfort, your healthcare professional

will assess your need for pain management and determine what approach is right for you



Restylane and Perlane side effects

• Most common side effects experienced with Restylaneor Perlane treatment are swelling, redness, pain, bruising and tenderness

• These will usually go away within a week. Call your healthcare professional if you experience problems for longer than 14 days


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• Cold compresses (a cloth dipped in cold water, wrung out, and applied to the injected area) may be used immediately after treatment to reduce swelling

• Avoid touching the treated area within six hours following treatment so you do not accidentally injure your skin while the area is numb. After that, the area can be gently washed with soap and water

• Until any redness or swelling goes away, avoid exposure of the treated area to intense heat (sun lamp or sun bathing)

What to do after treatment



• If you have previously suffered from facial cold sores, there is a risk that the needle punctures could contribute to another recurrence. Speak to your physician about medications that may minimize a recurrence

• Avoid taking aspirin, nonsteroidal anti-inflammatory medications, St. John’s Wort, and high doses of vitamin E supplements for one week after treatment. These agents may increase bruising and bleeding at the injection site

What to do after treatment



See Important Safety Considerations on Slides 28-30

Results with the Restylane family of products

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Restylane results



Restylane results



Restylane results



Perlane results



Perlane results



• Full correction means using the necessary amount of Restylane or Perlane to achieve your desired aesthetic effect in the appropriate treatment area

• The amount of product you receive may differ from what another patient may receive

• Work with your healthcare professional to determine what full correction means for you

What does full correction mean?



Restylane and Perlane—the look you want from a name you trust

• Restylane lasts up to 18 months with one follow-up treatment*

• Perlane lasts at least 6 months in the majority of patients after a single treatment†

• Over 10 million Restylane treatments worldwide‡

• Well-defined safety profile• Immediate results

Ask for Restylane or Perlane by name!* In a recent study, at least 95% of patients treated with Restylane experienced results for up to 18 months from initial treatment when they

returned for a follow‐up treatment at 4.5 or 9 months.

† In three clinical studies, the percentage of patients maintaining improvement at six months was 75%,71% and 63%, respectively.

‡ Includes Q‐Med AB HA products not available in the U.S.



Important Safety Considerations for Restylane and Perlane

After your treatment, you might have some swelling, redness, pain, bruising, and tenderness. This will normally last less than seven days. Although rare, red or swollen small bumps may occur. If you have had facial cold sores before, an injection can cause another outbreak. In rare circumstances, the doctor may inject into a blood vessel, which can damage the skin. To avoid bruising and bleeding, you should not use either product if you have recently used drugs that thin your blood or prevent clotting. If you are pregnant, breastfeeding, or under 18 years, you should not use Restylane or Perlane.



Restylane or Perlane should not be used by people with previous bad allergies, particularly to certain microorganisms known as gram-positive bacteria; by people with previous bad allergies to drugs that have required in-hospital treatment; or by people with bleeding disorders. Injections should not be made anywhere except the skin or just under the skin.

Patients should be limited to 6.0 mL per treatment. The safety or effectiveness of Restylane and Perlane for the treatment of anatomic regions other than nasolabial folds have not been established in controlled clinical studies.



The use of Restylane or Perlane at the site of skin sores, pimples, rashes, hives, cysts, or infection should be postponed until healing is complete. Use of either product in these instances could delay healing or make your skin problems worse.

Restylane and Perlane are available only through a licensed practitioner. Complete product and safety information is available at www.RestylaneUSA.com.



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Documents

A Patient’s Guide to Aesthetic Treatments€¦ · your specific needs, so the cost will vary from patient to patient • In general, the cost of a treatment is comparable to the