2007

EnzymesU 1100 A Novel and Convenient Method for the Synthesis of Ubiquinone-10. — A novel

and convenient synthetic approach to ubiquinone-10 (VII) is reported. The key step is the nucleophilic, copper-catalyzed displacement reaction between Grignard reagent (V) and the secondary allylic acetate (IV). The procedure is suitable for a large-scale production of ubiquinone-10. — (WANG, F.; JIANG, X.; HU, L.; DONG, S.; WU, X.; BAI, H.; ZHANG, Y.; STOECKIGT, J.; ZHAO*, Y.; Lett. Org. Chem. 3 (2006) 8, 610-612; Dep. Trad. Chin. Med. Nat. Drug Res., Coll. Pharm. Sci., Zhejiang Univ., Hangzhou 310058, Peop. Rep. China; Eng.) — M. Bohle

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