A Neuroendocrine Model for Healthy Aging

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A Neuroendocrine Model for Healthy Aging

Speaker: Sharon Norling, MD, MBADecember 13, 2013

Booth - 3046

Surgery Medicine

Prevalence of Mood Disorders

26.2% 18 and older – about 1 in 4 adults. 57.7 million people 45% meet criteria for 2 or more disorders Comorbidity

1. Kessler RC, Archives of General Psychiatry, 62(6) (January 2005): 617-27.2. U.S. Census Bureau Population Estimates by Demographic Characteristics.

CLIA High Complexity Clinical Testing Laboratory

CLIA: 34D1054007

NeuroLab™

Laboratory results include integrative clinical commentary personalized to the patient health data and current laboratory values.

Personalized medicine Treating the average is OVERATED! Neuroendocrine systems analysis of chronic and

acute conditions from depression to metabolic syndrome

Inhibitory Neurotransmitters

Serotonin GABA

Excitatory Neurotransmitters

Dopamine Nor-

epinephrine Epinephrine Glutamate

Adrenal Hormones

DHEA-s – (2-point)

Cortisol – (4-point)

Neurotransmitters

Anxious? Depressed? Mood swings? Difficulty sleeping? Experiencing pain? Lacking motivation? Low libido?

Pharmaceutical Drugs

Mood-altering drugs are considered affective if it reduces depression 50%

SSRI’s help 30-50 % of the time but have side effects 86% of the time

Turner looked at 74 clinical trials and found the drug worked 51% and the placebo 49%Erick H Turner MD, et al. “Selective Publication of Antidepressant Trials and Its Influence on Apparent Efficacy,” NEJM (January 17, 2008); 358: 252-60.

Evolution of Model Mood Disorders

Middle Ages: Demons within-exorcism is therapy of choice

1917: Freud explains that those demons are really our mothers

1988: Eli Lilly releases our mothers from 80 years of victimization, explaining that depression is really a Prozac deficiency

Dr. Hedaya, Clinical Professor of Psychiatry Georgetown University.

Disease Management & the Organization of Physician Practice

“There is a large gap between what physicians do for

patients with chronic diseases and what should be done.”

Disease Management and the Organization of Physician PracticeLawrence P. Casalino, MD, PhDJAMA. 2005;293(4):485-488.

Causes of Neurotransmitter

Imbalance Life Gluten Lack of nutrition and

blood sugar Hormone imbalance

Low thyroid Adrenal fatigue Toxins Infections Lack of sleep

LIFE





Gluten Sensitivity

Depression in 52% Injured GI lining decreases the effectiveness of

absorbing essential nutrients to keep the brain healthy.

Zinc, tryptophan, and B Vitamins “second brain” produces 80-90 percent of serotonin


Imbalance Life Gluten Lack of nutrition

and blood sugar Hormone imbalance


Vitamin D

Low levels contribute to depression and chronic fatigue

Adequate Vitamin D needed by the adrenal gland for the production of dopamine, epinephrine, and norepinephrine

Several months of supplementation

High Blood Sugar

“when your blood sugar rises there is an immediate depletion of the

neurotransmitters serotonin, epinephrine, norepinephrine, GABA, and dopamine. B-complex, which is needed to make neurotransmitters, gets used

up.”David Perlmutter, MD, Grain Brain (New York, Boston, London: Little, Brown and Company, 2013).

REAL EASY

REAL LIFE

REAL IMPORTANT

High Blood Sugar

“ The most powerful tool you have to change your body and your health is

your fork.”

Mark Hyman, MD



blood sugar Hormone

imbalance


Hormone Imbalance: Statins

“If you deprive the brain of cholesterol, then you directly affect the machinery that

triggers the release of neurotransmitters.

Cholesterol changes the shape of the proteins to stimulate thinking and memory.”

David Perlmutter, MD, Grain Brain (New York, Boston, London: Little, Brown and Company, 2013).

Hormones & Neurotransmitters

Strong interaction E2 and serotonin Progesterone and GABA Testosterone and DHEA





Symptoms of Low Thyroid Production

Depression Anxiety Decreased memory Inability to concentrate Migraine headaches

Muscle and joint pain Menopausal symptoms and PMS Insomnia Fatigue Low libido




Low thyroid Adrenal

fatigue Toxins Infections Lack of sleep

Adrenal Hormones

DHEA-s Cortisol

Dancing Hormones

AdrenalineGABA

CortisolThyroid

InsulinSerotonin

Estrogen Glutamate

Progesterone DHEA

DopamineTestosterone

NeuroLab™

Leading specialist in the technology, analysis, and research of the biomarkers relating to HPA-T axis function.

Leaders in the clinical application of urinary HPLC/MS testing.

Certified by CLIA as High Complexity Clinical Laboratory

Participates in College of American Pathology & BIORAD proficiency testing for salivary samples.

Amino acids

“We have found that if a drug can be found to do the job of medical healing, a nutrient can be found

to do the same job. We now know that if we give the amino acids the body will synthesize

neurotransmitters, thereby achieving the same effect as drugs.

The challenge of the future is to replace drugs with these natural healers.”

Dr. Carl Pfeiffer, a pioneer amino-acid researcher.

Step 1: Assessment

• Assess the patients’ neurotransmitter and adrenal hormone biomarkers with a non-invasive laboratory test

• Establishes a baseline on first test, looking for imbalances affecting HPA-T axis function.

• Important tool for monitoring and adjusting therapy to meet the patient’s individual biochemical needs

Step 2: Correlation

• Personalized laboratory results to patient specific symptoms and, current treatments, and lifestyle factors

• Comprehensive review of patient’s neuroendocrine system

Step 3: Correction

Sanesco’s exclusive line of TNT products are natural, non-drug formulas balanced with specific low dose amino acid precursors and nutrient cofactors designed to support neurotransmitter and hormone pathways showing imbalances affecting HPA-T axis function.

Targeted Nutritional Therapy- safe & clinically effective

Prolent™ (inhibitory support)

Lentra™ (GABA receptor support)

Procite-D™ (dopamine support)

Contegra™ (catecholamine formula)

MethyMax™ (methylation support)

Adaptacin™ (adrenal support)

Effective Clinical Tool

1. Symptomatic patient does a test

2. Test reveals a number3. Intervention is made4. Test is repeated5. Number improves

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Neurotransmitters

Gluten SensitivityHormones

•Anxiety•Depression•Insomnia•Fatigue•Joint Pain•Memory Loss•Poor Concentration•Low Libido•Carb Cravings•Muscle stiffness



Neurotransmitters

Hormones

•Anxiety•Depression•Insomnia•Fatigue•Joint Pain

•Memory Loss•Poor Concentration•Low Libido•Carb Cravings•Muscle stiffness

Gluten Sensitivity

Summary

Assess patients for mood disorders Remove known causes of imbalances Test using NeuroLab, leading specialty

laboratory in the technology, analysis, and research of HPA-T axis function

Balance neurotransmitters with Sanesco’s specific amino acid targeted nutrient therapy for safe effective clinical results

Neurotransmitters

Anxious? Depressed? Mood swings? Difficulty sleeping? Experiencing pain? Lacking motivation?

Low libido?

Question

Is thereSEX

before or after menopause ?

Sexual Frequency Across the Life CycleAge Frequency

30-40 Tri - weekly

40-50 Try weekly

50-60 Try weakly

60-70 Try

70-80 Try something else

Remember

Laughter is the BEST Medicine

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A Neuroendocrine Model for Healthy Aging

Dr. Sharon Norling5655 Lindero Canyon Rd

Westlake Village, CA

Your Doctor is Wrongwww.drsharonnorling.com

Come by booth 3046 for an opportunity to meet Sharon Norling MD, MBA and receive a signed copy

of the her book.

http://www.drsharonnorling.com/

http://www.drsharonnorling.com/

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A Neuroendocrine Model for Healthy Aging