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8/2/2019 A Meta-Analysis of Emotional Re Activity in Major Depressive Disorder_Bylsma_et_al_2008_cpr
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A meta-analysis of emotional reactivity in
major depressive disorder
Lauren M. Bylsma, Bethany H. Morris, Jonathan Rottenberg
Department of Psychology, University of South Florida, 4202 E. Fowler Ave, PCD4118G, Tampa, FL 33620, United States
Received 14 April 2007; received in revised form 30 September 2007; accepted 3 October 2007
Abstract
Three alternative views regarding how Major Depressive Disorder (MDD) alters emotional reactivity have been featured in the
literature: positive attenuation (reduced positive reactivity), negative potentiation (increased negative reactivity), and emotion
context insensitivity (ECI; reduced positive and negative reactivity). Although empirical studies have accumulated on emotional
reactivity in MDD, this report is to our knowledge the first systematic quantitative review of this topic area. In omnibus analyses of
19 laboratory studies comparing the emotional reactivity of healthy individuals to that of individuals with MDD, MDD was
characterized by reduced emotional reactivity to both positively and negatively valenced stimuli, with the reduction larger for
positive stimuli (d= .53) than for negative stimuli (d= .25). Results were similar when 3 major emotion response systems (self-
reported experience, expressive behavior, and peripheral physiology) were analyzed individually. The ECI view of emotional
reactivity in MDD is well supported by laboratory data. Implications for the understanding of emotions in MDD are discussed.
2007 Elsevier Ltd. All rights reserved.
Keywords: Major depression; Emotion; Affect; Reactivity; Meta-analysis
Contents
1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 677
1.1. Views of emotional reactivity in MDD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 678
1.2. Limitations of prior reviews . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 678
1.3. The present study . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6792. Methods . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 679
2.1. Overview. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 679
2.2. Rationale for emotion response domains covered in this review . . . . . . . . . . . . . . . . . . . . . . . 679
Available online at www.sciencedirect.com
Clinical Psychology Review 28 (2008) 676691
The authors express their appreciation to Michelle Jones for her help in library research and to the members of the Mood and Emotion Laboratory
for their comments. This research was supported by a University of South Florida New Researcher Grant awarded to Jonathan Rottenberg. Corresponding author. Tel.: +1 813 9746701; fax: +1 813 9744617.
E-mail addresses: [email protected] (L.M. Bylsma), [email protected] (B.H. Morris), [email protected] (J. Rottenberg).
0272-7358/$ - see front matter 2007 Elsevier Ltd. All rights reserved.doi:10.1016/j.cpr.2007.10.001
mailto:[email protected]:[email protected]:[email protected]://dx.doi.org/10.1016/j.cpr.2007.10.001http://dx.doi.org/10.1016/j.cpr.2007.10.001mailto:[email protected]:[email protected]:[email protected]8/2/2019 A Meta-Analysis of Emotional Re Activity in Major Depressive Disorder_Bylsma_et_al_2008_cpr
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2.3. Variables included in this review . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 680
2.4. Literature search . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 680
2.5. Study inclusion criteria . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 680
2.6. Characteristics of selected studies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 681
2.7. Computation of effect sizes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 681
2.8. Planned analyses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 683
3. Results . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 684
3.1. Omnibus analyses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 684
3.2. PER and NER in individual response systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 685
3.2.1. PER . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 685
3.2.2. NER . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 685
3.3. Heterogeneity and Moderator Analyses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 685
3.4. File drawer analyses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 686
4. Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 686
4.1. Limitations and future directions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 687
4.2. Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 688
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 688
1. Introduction
Major Depressive Disorder (MDD) is a debilitating condition that afflicts almost a sixth of the general population
(Kessler, 2002). Reflecting the profound disturbance of affective function in MDD, it is classified as a mood disorder
by the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV; APA, 2000). DSM-IV diagnostic criteria
specify symptoms of at least two weeks duration that implicate deficient positive affect (e.g., anhedonia), excessive
negative affect (e.g., guilt, sadness), or both. When queried, patients who have been diagnosed with MDD reliably
report low positive affect and elevated negative affect on a variety of questionnaire and interview measures ( Clark,
Watson, & Mineka, 1994). Durable disturbance of mood is thus one of the most salient features of MDD.
Given that MDD is quintessentially a disorder of mood, one important question is how MDD influences emotional
reactions. Addressing this question requires a distinction between the constructs mood and emotion (e.g., Rottenberg &Gross, 2003). Moods have been defined as diffuse, slow-moving feeling states that are weakly tied to specific stimuli in
the environment (e.g., Watson, 2000). By contrast, emotions have been defined as quick-moving reactions that occur
when an individual processes a meaningful stimulus (e.g., a threatening object). Emotional reactions are multi-
componential and typically involve coordinated changes in several response systems (e.g., perception, feelings,
expressive behavior, peripheral and central physiology; Ekman, 1992; Keltner & Gross, 1999). When mood and emotion
are so distinguished, it becomes apparent that the various diagnostic criteria for MDD, such as pervasive sadness or
anhedonia, indicate alterations in mood, but do not indicate alterations in emotion with corresponding specificity.
Although the constructs are distinguishable, moods and emotions have generally been seen as interconnected, with
moods altering the probability of having specific emotions (e.g., Rosenberg, 1998). More specifically, moods are
thought to potentiate like-valenced or matching emotions (e.g., irritable mood facilitates angry reactions, an anxious
mood facilitates panic, etc; Rottenberg, 2005). By extension, excessive negative mood in MDD would potentiatenegative emotional reactivity and/or a lack of positive mood would attenuate positive emotional reactivity. Indeed, the
idea of mood-facilitation is one guiding source for three major views regarding emotional reactivity in MDD: (1)
negative potentiation (2) positive attenuation and (3) emotion context insensitivity (ECI). We will briefly outline each
of these views before presenting a meta-analysis designed to determine which of them best fits the accumulated data
concerning emotional reactivity in MDD.
Our main goal was to conduct a systematic meta-analytic review of the literature on emotional reactivity in MDD.
We used rigorous literature search strategies (see below) to identify laboratory studies of emotional reactivity in MDD
and estimate effect sizes. We report effect sizes from 19 laboratory studies that compared negative and positive
emotional reactivity between individuals with MDD and healthy participants. Analyses focused on omnibus group
differences in positive and negative emotional reactivity, as well as the replicability of these group differences within
three specific emotion response systems: self-report, behavioral, and peripheral physiological reactivity. To our
knowledge, this study represents the first meta-analytic review of the literature on emotional reactivity in MDD.
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1.1. Views of emotional reactivity in MDD
Negative potentiation, the first view, holds that the pervasive negative mood states that are prevalent in MDD
contribute to potentiated emotional reactivity to negative emotional cues. Perhaps most relevant to the idea that
negative moods and negative emotions are mutually reinforcing in MDD, cognitive theorists see negative moods as
facilitating negative cognitive processing which, in turn, results in negative cognitive interpretations that generatedysphoric reactions (e.g., Beck, 1976; Beck, Rush, Shaw, & Emery, 1979). Beck's schema model and related theories
of depression (e.g., Bower, 1981) conceptualize MDD in terms of cognitive structures, or schemas, which are patterns
in thinking that serve to negatively distort the processing of emotional stimuli (e.g., such as beliefs that one is unlovable
or a failure). Importantly, according to these theories, negative mood states prime, or activate, these cognitive structures
(Scher, Ingram, & Segal, 2005). Once activated, these structures precipitate negative interpretations which give rise to
depressotypic emotional responses (e.g., crying spells) whenever schema-matching negative emotion stimuli are
encountered, presumably potentiating reactivity to negative emotional stimuli in MDD.
Positive attenuation, the second view, holds that individuals with MDD will have reduced reactivity in response to
positive emotional stimuli. Because this hypothesis applies primarily to positive emotional stimuli, positive attenuation
is compatible with negative potentiation (i.e., individuals with MDD can exhibit both patterns simultaneously). The
starting point for this hypothesis is the depressed persons' strong tendency to exhibit low positive mood. Indeed,anhedonia (the reduced ability to experience pleasure) is one of the cardinal symptoms of MDD, and depressed
individuals exhibit several other signs that are also indicative of deficient appetitive motivation (e.g., psychomotor
retardation, fatigue, anorexia, apathy). Not surprisingly, several theorists have centered their accounts of abnormal
emotional responding (e.g., abnormally low emotion response magnitude) in MDD on this constellation of
motivational deficits (e.g., Clark et al., 1994; Depue & Iacono, 1989) often focusing on the central nervous system
substrates for deficient appetitive motivation (e.g., hypoactivation in the left frontal lobes; Henriques & Davidson,
1991).
Emotion context insensitivity (ECI), the third view, holds that depressed individuals will exhibit reduced reactivity
to all emotion cues, regardless of valence (Rottenberg, 2005, 2007). By this account, individuals with MDD should
exhibit less reactivity to both positive and negative stimuli and events compared to healthy individuals. ECI is derived
from evolutionary accounts that describe depression as a defensive motivational state that fosters environmental
disengagement (Nesse, 2000). According to this view, depressed mood states evolved as internal signals to biasorganisms against action in adverse situations where continued activity might be potentially be dangerous or wasteful
(e.g., famine). Thus, according to ECI, severe depressed mood states in MDD are postulated to inhibit ongoing
emotional reactivity. In sum, ECI makes similar predictions as the positive attenuation view for positive stimuli, but
makes opposite predictions as the negative potentiation view for negative stimuli.
1.2. Limitations of prior reviews
Prior generalizations about emotional reactivity in MDD have been based on narrative reviews, which can be
susceptible to selection biases and are often unsystematic in their search strategies. Any review also faces the
complexity of operationalizing the major constructs relevant to this topic area. For example, the depression construct
can be operationalized in different kinds of samples (e.g., analogue samples of dysphoric persons versus case-levelMDD), and even studies of MDD may consider related conditions, such as dysthymia or minor depression, to be part of
the depression construct. Thus, reviews may describe different effects of depression on emotional reactivity because
different kinds of depressive phenomena are being considered. Likewise, complexity in the emotion construct also
complicates the task of review. Emotional reactivity can be operationalized in a large number of response systems,
which often exhibit considerable independence from one another (e.g., self-reported experience, expressive behavior,
cognition, peripheral nervous system responding, or neural activity, see Mauss, Levenson, Carter, Wilhelm, & Gross,
2005). Prior reviews have not made a concerted effort to integrate data across self-report, behavioral, and physiological
domains (e.g., Forbes, Miller, Gohn, Fox, & Kovacs, 2005; Gehricke & Shapiro, 2000). Further, even within any given
system of response, emotional reactivity can be computed using different metrics (e.g., level scores versus change
scores), and commentators have generally not been explicit and/or systematic in defining their choice of reactivity
metric. Given these multiple challenges, perhaps it is not surprising that prior narrative reviews in this area of research
have been inconclusive.
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1.3. The present study
To overcome the limitations of prior reviews, we assessed the literature on emotional reactivity in MDD using
meta-analysis an important quantitative technique for systematically summarizing results across different
studies which use different measurement techniques and arriving at stable estimates of effect sizes (Cohen, 1988).
In contrast to narrative reviews, meta-analysis avoids reliance on statistical significance tests and provides precisequantitative estimates of the magnitude of effect sizes. For this meta-analysis, only studies that elicited emotion in
a well-controlled manner and used DSM diagnostic criteria for MDD were included. Analyses focused on the
extent to which MDD might increase or decrease positive and negative emotional reactivity relative to healthy
individuals.
2. Methods
2.1. Overview
A meta-analytic procedure was used to estimate the effect of MDD on emotional reactivity. Our major focus was on
positive emotional reactivity (PER; i.e., emotional reactivity to a positively valenced stimulus) and negative emotionalreactivity (NER; i.e., emotional reactivity to a negatively valenced stimulus). Emotional reactivity was defined as a
positive (PER) or negative (NER) measured emotional response to a matching emotionally valenced stimulus that is
reflected as a change from baseline affect. We focused on these two forms of emotional reactivity rather than specific
emotions because (1) the major views of emotional reactivity in MDD concern PER and NER (2) valence has high
theoretic importance in the emotion literature (e.g., Barrett, 2006), and (3) insufficient research exists to allow pooling
of results for specific emotions.
2.2. Rationale for emotion response domains covered in this review
One general challenge in conducting a meta-analysis of PER and NER is the overwhelming number of responses
that are potentially relevant to emotion. Relatedly, there is a lack of consensus among affective scientists regarding just
how many emotion response systems there are, and how all of these response systems should be mapped on to theemotional reactivity construct (e.g., posture, touch, perceptual changes, Rottenberg & Johnson, 2007). To make this
problem more tractable, we made a judgment to focus our review on three response systems that are important to
emotional reactivity: (1) behavioral/expressive, (2) experiential/subjective, and (3) peripheral physiological responding
in the autonomic nervous system. These three systems were prioritized for four main reasons: First, these three systems
have been historically important in guiding inquiry in emotion (e.g., Dolan, 2002; Ekman, 1992; Lang, Rice &
Sternbach, 1972; Lang, 1988; Lazarus, 1991; Levenson, 1994). Second, there is reasonably good agreement that these
three systems do in fact index emotional reactivity. Third, there is reasonably good agreement on measures that can be
extracted from these systems to index emotional reactivity (see below). Fourth, there is an adequate database of
empirical studies using metrics from these three systems in MDD to conduct a meta-analysis.
Although a focus on these three systems affords our review some breadth as well as some fidelity to the construct of
emotion, this review is by no means all-inclusive of systems that are relevant to emotion. Perhaps most importantly,neurological and endocrine systems play a major role in emotional reactivity (e.g., LeDoux, 1998). However, we did
not include neuroimaging metrics (e.g., techniques such as fMRI, PET, and ERP), because existing reviews of
neuroimaging and emotion indicate that considerable disagreement remains about how to map emotional reactivity
onto these techniques (e.g., Murphy, Nimmo-Smith, & Lawrence, 2003; Phan, Wager, Taylor, & Liberzon, 2002).
More practically, an early inspection of potentially relevant studies indicated that imaging studies of MDD did not
routinely report statistics needed for computing effect sizes. Further, the technical problems of conducting meta-
analytic analyses of neuroimaging data are considerable, as these are far from simple computations of effect sizes,
and, typically, effect sizes based on standardized mean differences cannot be calculated due to the complexity of the
data, and because the focus is typically on activity location rather than effect size ( Fox, Parsons, & Lancaster, 1998).
Fox et al. (1998) have noted that meta-analytic procedures do not provide an adequate way of combining
neuroimaging and non-neuroimaging measures into a single meta-analysis for both methodological and theoretical
reasons. For these reasons, separate meta-analytic procedures must be used for neuroimaging data that have different
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theoretical interpretations. Likewise, we did not consider the domain of cognition to be tractable for our purposes,
even though cognition and emotion interact (e.g., Gray, 2004), and cognitive changes are among the known correlates
of emotional reactions. An inspection of the literature suggests that cognition is extraordinarily heterogeneous as a
domain, and that there is little agreement or precedent concerning how metrics from the cognitive domain (e.g.,
memory bias, perceptual judgments, reaction times, etc) should be mapped onto the emotional reactivity construct for
meta-analysis.
2.3. Variables included in this review
Selection of measures of emotional reactivity within the three response systems covered in this review (self-reported
experience, expressive behavioral, and peripheral physiological) was guided by prior literature demonstrating that each
measure could be interpreted as a valid index of emotional reactivity. Self-report measures of emotional responses
included subjective reports of emotional experience through various self-report measures such as the PANAS (Watson,
Clark, & Tellegen, 1988), the SAM (Bradley & Lang, 1994), or discrete emotion measures. Behavioral measures
included observed facial expression as measured through facial coding systems (e.g., FACS; Ekman, Matsumoto, &
Friesen, 2005; Lang, Greenwald, Bradley, & Hamm, 1993) or electromyographic (EMG) recordings of the face (e.g.,
Cacioppo, Martzke, Petty, & Tassinary, 1988; Cacioppo, Petty, Losch, & Kim, 1986; Lang et al., 1993 ), emotion-modulated eyeblink/startle responses (e.g., Bradley, Cuthbert, & Lang, 1999; Bradley & Lang, 2000 ), and approach/
avoidance behavior (e.g., Carver, 2001; Henriques & Davidson, 2000). Physiological measures included measures of
autonomic peripheral physiology, specifically including skin conductance responses (SCR; e.g., Lang et al., 1993),
heart-rate variability (HRV)/respiratory sinus arrhythmia (RSA) (e.g., Appelhans & Luecken, 2006; Butler, Wilhelm, &
Gross, 2006), blood pressure (e.g., Melamed, 1987), respiration (e.g., Ritz, Thons, Fahrenkrug, & Dahme, 2005), heart
rate (e.g., Lang et al., 1993), and finger pulse amplitude (FPA; e.g., Gross, 2002).
2.4. Literature search
This review covered published journal articles in the English language since 1975. Only published articles were
reviewed for possible inclusion, because published work generally has increased scientific rigor compared with
unpublished work, and because it is readily available within the public domain for independent evaluation by others.Because null results may be more difficult to publish than significant findings (potentially leading to upward biases of
effect sizes in the published literature), we included file-drawer analyses to provide an estimate of the number of
studies with non-significant results that would be necessary to alter the interpretation of the primary results ( Rosenthal,
1991).
To generate potentially relevant articles, the first author used the PsychINFO and MEDLINE online database,
entering the following keywords: depress and emotion reactivity, depress and affect modulation, depress and
affect regulation, depress and emotion functioning. The wildcard was used to ensure that all forms of the
keywords were searched. After identifying potentially relevant articles, the reference sections were searched to identify
additional articles which might meet our inclusion criteria. As an additional check to ensure that no relevant articles
were omitted, a research assistant also performed a parallel search.
2.5. Study inclusion criteria
Articles were required to meet the following inclusion criteria (a) a group of participants that qualified for a
diagnosis of current MDD using DSM criteria (b) a healthy control group, (c) appropriate statistics (e.g., means and
standard deviations) that were reported in the published article or available from the author upon request (of nine
articles that were missing data, the study authors were able to supply it in six cases), (d) measured emotional reactivity
with self-reported experience, expressive behavioral, or peripheral physiological indicators (e) a positively or
negatively valenced emotion elicitation condition was included, along with (f) a neutral or baseline condition to allow
computation of NER and PER (without a baseline of comparison responses to a valenced stimulus may reflect a general
disposition or mood rather than reactivity to a given stimulus). Medication use by patients was not considered as an
inclusion/exclusion criterion because virtually no studies in the entire literature used an un-medicated sample (our
search yielded only four such studies).
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2.6. Characteristics of selected studies
From an initial screening, a total of 35 potential articles were found. However, 6 of these did not include a control
group, 4 did not include a neutral or baseline measure, 2 were not laboratory studies, and 3 did not include the necessary
means and/or standard deviations for inclusion in the meta-analysis and the authors were unable to be contacted. The
final sample for inclusion in the analysis consisted of 19 articles. All articles included measures of NER, and 14 alsoincluded measures of PER. Because many of the articles includes measures of multiple response systems, overall there
were 29 measures of NER and 24 measures of PER across response systems. The pooled sample size consisted of 465
participants with MDD and 452 control participants. See Table 1 for a summary of selected characteristics of studies
included in the meta-analysis1.
The demographic characteristics of participants in the included studies appeared to be consistent with the known
epidemiology of MDD. The majority of the studies included more females than males in their samples, consistent with
the prevalence rate of depression being higher in females (Kessler, 2002). Seven studies only included female
participants, and one only included males. Most studies specified excluding participants with co-morbid psychosis,
bipolar disorder, or substance abuse. However, co-morbid anxiety diagnoses were typically included (only two studies
stated that they excluded for all anxiety disorders). Five studies specified including inpatient MDD samples, and 11
specified using outpatient samples. The majority of included studies did not report ethnicity or other participantdemographic information. Only one study (Tsai, Pole, Levenson, & Munoz, 2003) used a minority sample which
consisted of Spanish-speaking Latinas, and one study used a British sample in London ( Kaviani, Gray, Checkley,
Raven, Wilson, & Kumari, 2004).
2.7. Computation of effect sizes
We conducted the analyses using the Hedges and Olkin approach (1985) which weights each study by the inverse
of the variance, which is roughly proportional to the study's sample size. Effect sizes were computed using Cohen's
1 Studies excluded from the meta-analysis after the initial screening.
No control group:
Carney, Hong, Brim, Plesons, and Clayton (1983)
Greden, Price, Genero, Feinberg, and Levine (1984)
Rottenberg, Wilhelm, Gross, and Gotlib (2002)
Rottenberg, Salomon, Gross, and Gotlib (2005)
Schwartz, Fair, Mandel, Salt, Mieske, and Klerman (1976)
Schwartz, Fair, Salt, Mandel, and Klerman (1976)
No baseline or neutral measure:
Berenbaum and Oltmanns (1992)
Katsikitis and Pilowsky (1991)
Renneberg, Heyn, Gebhard, and Bachmann (2005)
Tremeau et al. (2005)
Not laboratory studies (naturalistic):
Peeters, Nicolson, and Berkhof (2003)
Peeters, Nicolson, Berkhof, Delespaul, and deVriews (2003)
Missing data necessary for computation of effect sizes:
Iacono, Lykken, Haroian, Peloquin, Valentine, and Tuason (1984)
Lapierre and Butter (1980)
Wexler, Levenson, Warrenburg, and Price (1994)Yecker, Borod, Brozgold, Martin, Alpert, and Welkowitz (1999).
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d, a common measure of effect size (Cohen, 1988). Effect sizes were calculated as (M1M2)/SDp where M1 is the
control group mean, M2 is the MDD group mean, and SDp is the pooled standard deviation. This represents the
standardized mean difference between groups. Standardizing these means allowed us to account for scaling
differences between different types of measures and pool data across studies. The means used to compute the effect
sizes were the average self-report, behavioral, or physiological emotional reactivity scores. If the study did not
report emotional reactivity scores directly, these scores were derived by subtracting neutral or baseline conditionmean scores from positive or negative response mean scores. In this case, the standard deviation was first pooled
from the standard deviations of the positive and negative response mean scores and the neutral or baseline
conditions, and then this pooled standard deviation was used in the equation above to pool across groups in the
calculation of the effect sizes. All effect sizes were calculated using the Comprehensive Meta-analysis software
package (Biostat, 2005).
A variety of stimuli in the primary studies were used to elicit valenced emotional responses that have received
some support from previous research as being valid measures of emotional reactivity, including emotional films or
audio recordings describing an emotional situation (Rottenberg, Ray, & Gross, 2007), emotional pictures from the
International Affective Picture System (IAPS; Lang, Bradley, & Cuthbert, 2005), facial expressions of emotion from
the Facial Affective Booklet (FAB; Ekman, 1976, Ekman & Oster, 1979), standardized laboratory stressors such as a
loud noise or mental arithmetic tasks (Krantz, Manuck, & Wing, 1986), and the presentation of rewards (Henriques,Glowacki, & Davidson, 1994). Most of the behavioral and physiological studies also used self-report measures to
validate whether the appropriate emotion was elicited. In order to ensure that emotional reactivity, defined as
emotional reaction to a particular positively or negatively valenced stimulus, rather than a more general disposition
of mood was assessed, we defined PER and NER as a change from a baseline condition. Rest and response to a
neutral stimulus (e.g., a neutral film) were both considered acceptable baselines. We felt this liberal definition of
baseline was justified in light of disagreement concerning what constitutes an optimal baseline condition for
assessing the effects of emotional reactivity (for a discussion see, for example, Rottenberg et al., 2007). The more
liberal definition of baseline also allowed us to retain as many studies as possible in the meta-analysis. Nevertheless,
when both a resting baseline and a neutral baseline were reported in the same study, we used the neutral condition,
because we believe there are drawbacks associated with using the resting baselines (e.g., rest may not be a
representative state of the organism, rest instructions may introduce unwanted variability, etc. For details, see
Rottenberg et al., 2007).When the authors of the studies included in the meta-analysis used more than one type of emotional reactivity
measure for PER or NER those effect sizes were summarized by simply using the mean effect size for the omnibus
analyses. For the analyses within each domain, averaging was only done if there was more than one emotional
reactivity measure for PER or NER within a domain. Using the mean effect size is conservative, as it gives a lower
estimate compared to overall composite variables (Rosenthal & Rubin, 1986). An alternate method would be to
calculate the overall composite effect sizes. However, in order to make this computation, the inter-correlations between
the multiple dependent measures would be needed and, in most studies, they were not reported.
2.8. Planned analyses
Primary omnibus analyses examined NER and PER across emotion response systems. Since activity in differentemotion response systems are not always strongly inter-correlated (Lang, 1968; Mauss, Wilhelm, & Gross, 2004),
and may even dissociate (e.g., Lang, 1988), we conducted secondary analyses within each emotion response
domain (reported experience, behavior, and physiology) to examine the consistency of emotional reactivity across
domains.
The primary analyses employed a fixed effects model, which has high power and remains the predominant model in
meta-analyses of psychological research (Hunter & Schmidt, 2000). However, fixed effects models have been
criticized for inflating Type I error, especially if there is heterogeneity in the data (Hunter & Schmidt, 2000). Due to the
small number of studies available for this meta-analysis and the unknown size of the expected effects, we chose to use
the fixed effects model as the primary model. We also ran tests of heterogeneity of the effect sizes using Cochran's
heterogeneity statistic Q (Cochran, 1954). Since heterogeneity can potentially inflate Type I error in a fixed effects
approach, we planned to re-run the analyses using a random effects model, if analyses revealed significant
heterogeneity in the data.
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3. Results
3.1. Omnibus analyses
We first conducted omnibus analyses of positive and negative emotional reactivity using the fixed effects model.
The analysis of positive emotional reactivity (PER) was significant (pb .0001) and revealed that PER was reduced inMDD compared to normal controls (see Fig. 1). The effect size for PER was d= .53, a medium-sized effect by
Cohen's (1988) conventions. Similarly, the omnibus analysis of negative emotional reactivity (NER) was also
significant, (pb .0001) and revealed that NER was reduced in MDD compared to normal controls (see Fig. 1). The
effect size for NER was d= .25, corresponding to a small effect size. When PER and NER effect sizes were compared
in a moderator analysis (with effect type PER versus NER coded as a moderator variable), a significant effect was
obtained (Q =7.21, pb .01), reflecting that the PER effect was significantly larger than the NER effect, indicating that
MDD individuals exhibited a more pronounced blunting of PER than of NER.
Fig. 1. PER and NER across all domains. The MDD group exhibits reduced PER and NER compared to controls ( pb
.0001). Error bars represent 95%confidence intervals.
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We conducted analyses of heterogeneity of both the PER and NER omnibus analyses to measure the variation
around the mean weighted effect sizes. Significant heterogeneity was present for both PER (Q =111.80, pb .0001) and
NER (Q =34.77, p = .01). Given the presence of heterogeneity in the magnitude of the effect sizes, we ran the planned
follow-up random effects analysis for PER and NER. The random effects analyses, despite their reduced power,
revealed similar results for both PER (d= .59, p =.011) and NER (d= .26, p =.008), with virtually identical effect
sizes to those in the fixed effects analyses. Since the heterogeneity in omnibus analysis suggests the possible presenceof moderator variables, additional analysis of potential moderators is presented below.
3.2. PER and NER in individual response systems
3.2.1. PER
To examine the extent to which reduced PER generalized across different systems of emotional response, separate
meta-analyses were conducted on the self-report, behavioral, and physiological indicators of PER. For both self-report
and behavioral measures of PER, it was found that PER in MDD was reduced relative to controls. For self-report
measures of PER, the effect size was d= .703 (pb .0001), a large effect. This analysis included 10 studies with a
sample size of 263 MDD individuals and 249 controls. For behavioral measures of PER, the effect was medium-sized
(d=
.453, pb
.0001). The analysis of behavioral measures included 10 studies with 290 MDD individuals and 250controls. Only 4 studies (with a total sample of 122 MDD individuals and 89 controls) included physiological measures
of PER, and although the direction of effect was also towards a reduction of PER in MDD, none of these found a
significant effect. When data from these 4 studies was pooled the overall analysis was non-significant (p =.293), with a
very modest effect size for PER (d= .151).
3.2.2. NER
To examine the extent to which reduced NER generalized across different systems of emotional response,
separate meta-analyses were conducted for self-report, behavioral, and physiological indicators of NER. For self-
report measures of NER, the effect size was medium ( d= .359, pb .0001). This analysis included 11 studies with
a total sample size of 279 MDD individuals and 264 controls. For behavioral measures, the effect size was small
(d= .054, and was not statistically significant, p =.544). For the analysis of behavioral measures, there were 9
studies, with a sample of 290 MDD individuals and 249 Controls. Finally, there was a medium effect forphysiological measures of NER (d= .223, pb .05). For the physiological measures, there were 8 studies, with a
sample size of 196 MDD individuals and 220 controls. In sum, similar to results for PER, when each emotional
response system was examined separately individuals with MDD exhibited reduced NER compared to controls in
two of the three systems.
3.3. Heterogeneity and Moderator Analyses
Omnibus analyses presented earlier indicated that effect sizes for both PER and NER were heterogeneous. Given
that all three distinct response systems were analyzed together, this was not completely surprising. To help isolate the
sources of heterogeneity, we also ran tests of heterogeneity within each emotion response system. For NER, the effect
sizes in the physiological analyses had significant heterogeneity (Q =21.16, pb .01), self-report effect sizes hadmarginally significant heterogeneity (Q =17.19, p =.05) and behavioral (Q =8.67, p =.37) were not heterogeneous. For
PER, behavioral (Q =150.46, pb .0001) and self-report (Q =86.70, pb .0001) but not physiological analyses (Q =0.39,
p =.82) indicated significant heterogeneity. Thus, the only response system which exhibited heterogeneity with any
consistency was self-reported emotion, which may be due to the diverse measures included within this domain of
emotional responding. Heterogeneity can also indicate the presence of outliers in the data. The PER behavioral
measures demonstrated most notable degree of heterogeneity. From a visual inspection of the plot of the PER
behavioral effects sizes, it would appear that were two outliers present. Specifically, all of the effect sizes fell within the
narrow range of .22 to +.10 except for two outliers (+0.64 and 3.95).
The presence of moderator variables, which systematically influence the effect sizes, can also cause heterogeneity.
We originally intended to run additional moderator analyses designed to identify variables that might account for
systematic variation in PER and NER effect sizes (e.g., medications, depression severity, co-morbidity). Unfortunately,
these analyses were either impossible due to inadequate information from primary studies and/or were underpowered
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(see Discussion below).2 The small subset of studies available for each response system likewise precluded adequately
powered analyses of potential moderator variables within each system.3
3.4. File drawer analyses
Finally, since our review considered only published sources, we conducted file-drawer analyses to assess thereliability of the omnibus effects in the face of additional unpublished null results ( Rosenthal, 1991). For the probability
for the omnibus analysis of PER to become non-significant (pN .05), there would have to be over 90 unpublished
studies with non-significant results hidden away in the file-drawer. Similarly, for the omnibus analysis of NER to
become non-significant, over 40 unpublished studies with non-significant results would be needed.
4. Discussion
MDD is well-established as a disorder of mood, but theories and prior narrative reviews have disagreed about how
MDD influences ongoing emotional reactivity. This meta-analysis represents the first quantitative review of the MDD
emotional reactivity literature. The major results indicate that MDD involves consistent reductions in both PER and
NER. These results have implications for each of the three major views of emotional reactivity in MDD. First, as NERwas found to be reduced rather than increased, the negative potentiation view was not supported. Second, the reduction
of PER in MDD, and the fact that the PER effect was larger than the NER effect both provided good support for the
positive attenuation view. Third, the ECI view appears to offer the most parsimonious overall account of these data
because (1) the pattern of decreased emotion reactivity in MDD was not restricted to PER, and (2) the ECI view
uniquely predicts reduced NER.
Lending additional credence to the ECI view, these reductions in PER and NER were robust in several respects.
First, both effects were highly statistically reliable. Second, file-drawer analyses indicated that the present results for
overall NER and PER would hold even in the face of a substantial number of unpublished null results. And third, the
reductions in PER and NER appeared to generalize across different systems of emotional response, and were not
restricted to a single response system.
These results also have more general implications for the study of how moods and emotions interact. Although
moods and emotions are highly familiar constructs that have generated extensive research, it is not yet clear how thesetwo kinds of affective processes are related. Intuitively, it makes sense that emotional reactions are stronger when they
are congruent with a preexisting mood, an idea reinforced by contemporary emotion theory. Yet there are surprisingly
few strong empirical demonstrations that moods actually facilitate emotional reactivity to mood-congruent stimuli. In
this respect, the analyses presented here appear to provide a notable exception to the idea of mood-facilitation.
Excessive negative mood in MDD should potentiate NER by the logic of mood-facilitation, yet this was clearly not the
case in the present data. One hypothesis to help make sense of this paradox is that moods may have non-linear effects
on emotional reactivity, with mood-facilitation holding for mild and moderate depressed mood states but not for severe
depressed mood states. Although this hypothesis waits further testing, the idea that milder depression potentiates NER
2 For example, we attempted to examine whether depression severity exerted a systematic effect on emotion reactivity in MDD; however, the
studies included in the meta-analysis inconsistently reported severity measures. For the measures that reported BDI scores for the MDD group,
we correlated these scores with the NER and PER effect sizes. No significant correlation was found for either NER ( r=.156, p =.647) or PER
(r= .452, p =.190); however, this may be due to the limited number of studies providing BDI data (11).3 Given that depression is defined diagnostically by tonic mood disturbances, we conducted additional exploratory analyses that examined the
extent to which PER and NER differences between studies in self-reported, behavioral, and physiological reactivity might be explained by tonic,
baseline differences in each corresponding system of measured response. In self report of affect at baseline, as expected, MDD individuals on
average reported less positive affect (d=0.865, pb .0001) and more negative affect (d=1.454, pb .0001) than controls. However, correlational
moderator analyses did not find a significant relationship between the magnitude of positive affect baseline differences and self-report indices of
PER (r=.26, p =.49). Likewise, no significant relationship was found between the magnitude of negative affect baseline differences and self-report
indices of NER (r=.48, p =.34). For behavioral measures, the groups did not differ at baseline in positive ( d=.005, p =.968) or negative (d= .154,
p = .188) behavioral indices. For physiological indices, MDD individuals exhibited higher activation at baseline compared to controls (d=.263,
pb .05). Too few studies were available to examine the association of baseline physiology with physiological indices of PER. However, the
magnitude of the difference in baseline activation was not correlated with physiological indices of NER ( r= .352, p =.439). Although the low
number of included studies limited the power of these analyses, there did not appear to be a strong relationship between tonic differences in responseand observed differences in PER and NER.
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is consistent with a number of analog studies of dysphoric samples that have obtained data consistent with this
prediction (Golin, Hartman, Klatt, Munz, & Wolfgang, 1977; Lewinsohn, Lobitz, & Wilson, 1973 ). Careful assessment
of emotional reactivity in samples that contain individuals with the full range depressed mood will be critical for testing
for non-linear effects, an analysis that may enrich an already active debate about whether depression is best conceived
as a continuum or a discrete category (e.g., Beach & Amir, 2003).
4.1. Limitations and future directions
While this study adds to our knowledge about emotions in MDD and has implications for the understanding of
normal mood variation, four important limitations should be noted. First, to estimate effect sizes for PER and NER, this
review prioritized the controlled measurement of emotion in laboratory settings. It is an open question as to whether
these laboratory findings generalize to naturalistic settings. The research database that examines emotion in everyday
life adults among with MDD is currently limited; thus studies that use emotion experience sampling techniques (e.g.,
Peeters, Berkhof, Delespaul, Rottenberg, & Nicolson, 2006) or informant ratings of emotion drawn from ecologically
important contexts (e.g., spousal relations) represent important directions for future work.
Second, there was significant heterogeneity in the omnibus analyses of NER and PER as well as consistent
heterogeneity in the self-report system when individual response systems were analyzed, but the proximal source(s) ofthis heterogeneity were difficult to isolate. Second, we were not able to identify moderators that might explain
systematic variation in PER and NER effect sizes across studies, either because the relevant information in the primary
studies was incomplete or absent and/or because the analyses of candidate moderators were underpowered. This point
merits emphasis.
For example, it is possible that the antidepressant medications commonly taken by individuals with MDD could
influence the magnitude of PER and NER (Tomarken, Shelton, & Hollon, 2007). The studies in this meta-analysis were
disparate in their practices with respect to medications. Very few studies used a non-medicated or an all-medicated
sample, and the all-medicated samples were often taking a variety of medications, which typically were not reported in
sufficient detail to analyze in any meaningful way.
Another possible moderator that could not be addressed by the present meta-analysis was co-morbid
psychopathology in the MDD individuals. Most studies did not exclude for anxiety or personality disorder co-
morbidity, and did not report emotional reactivity in pure MDD separately. In fact, only two studies excluded for alltypes of anxiety disorders in MDD individuals, which are commonly co-morbid with MDD (DSM-IV; APA, 2000). The
effect of co-morbid disorders on PER and NER in MDD is not well understood, but there are indications in the
literature that anxiety levels and forms of co-morbidity such as substance use (Zvolensky & Schmidt, 2003) may
influence the magnitude of observed effects on emotional reactivity in MDD. For example, one study (Kaviani et al.,
2004) found that within MDD individuals, anxiety levels as measured by self-report measures were associated with
increasedreactivity as measured by EMG for both positively and negatively valenced film clips. In sum, the presence
of normative co-morbidity in MDD samples precludes any strong claim that blunted emotional reactivity is specific to
MDD. To advance such a claim, it would be useful to have carefully conducted comparisons of emotional reactivity
between pure samples of MDD participants, co-morbid MDD participants and participants with other psychiatric
conditions.
Moreover, heterogeneity of MDD samples with respect to symptom severity, and demographic characteristics arealso potential factors that influences the magnitude of PER and NER. Samples of MDD individuals in this meta-
analysis were drawn from a variety of sources and included inpatients, outpatients, and untreated individuals recruited
from the general population. Preliminary moderator analyses designed to examine the relationship between depression
severity and emotion reactivity found no relationship (see footnote 1), but because of incomplete data, this analysis did
not provide a strong test. Other work has suggested that the severity of MDD may have an effect on emotion reactivity
(Rottenberg, Kasch et al., 2002). Finally, it is also possible that emotional reactivity in MDD varies as a function of
depression subtype (e.g., atypical versus melancholic MDD). Unfortunately, the majority of the studies did not specify
into which subtype individuals in their MDD samples fell. Finally, the sparse reporting of race, ethnicity, and
socioeconomic status, precluded analyses of these factors despite the fact that these demographic factors may be
important in modifying emotional reactivity (e.g., Gallo, Bogart, Vranceanu, & Matthews, 2005).
In light of these considerations, we strongly recommend that researchers be more conscientious in their reporting on
possible moderators of emotional reactivity in MDD, including medications, co-morbid anxiety, gender, demographic
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variables, depression severity, depression subtypes. Importantly, despite the multiple factors which might influence
PER and NER, and the well known heterogeneity of depression, this meta-analysis found reliable effects for NER and
PER. In fact, the effect sizes for NER and PER appear to be comparable in magnitude to those found in other meta-
analyses in related domains (e.g., Matt, Vazquez, & Campbell, 1992; Mor & Winquist, 2002).
Finally, as noted earlier, a fourth limitation of this meta-analysis is that it did not include every response system that
is relevant to the emotion construct. Thus, one important avenue for future work will be to examine the generalizabilityof the findings presented here to other response systems. Interestingly, a recent meta-analysis of a substantial literature
on endocrine responses to stress in MDD (which focused on the hormone cortisol) found reduced reactivity in MDD
(Burke, Davis, Otto, & Mohr, 2005), which is consistent with the ECI view. Evidence from neural systems involved in
emotional responding in MDD is not easily summarized in narrative form, but the possibility should be noted that
findings may be more mixed than our meta-analytic results. For example, Deldin, Keller, Gergen, and Miller (2000)
used ERP to measure encoding of emotional stimuli in individuals with MDD and controls and found that controls
showed enhanced P300 during encoding and reduced P300 during recognition of positive stimuli, which the authors
interpreted as a response bias for positive information. Using fMRI, a blunted response in the amygdala to facial
expressions of fear (relative to neutral) has been observed in both depressed adults (Drevets, 2001) and depressed
children (Thomas et al., 2001), which might be interpreted in terms of ECI. However, consistent with the negative
potentiation view, Siegle, Steinhauer, Thase, Stenger, and Carter (2002) found that MDD individuals exhibited asimilar initial amygdala response but greater sustained amygdala activity in response to negative words. In this same
study, and underlining the complexity of this domain, the MDD individuals exhibited decreased reactivity in
dorsolateral prefrontal cortex (DLPFC), compared to controls for the same negative words. Relatedly, Canli, Sivers,
Thomason, Whitfield-Gabrieli, Gabrieli, and Gotlib (2004) found that MDD individuals had increased reactivity to
negative words in the inferior parietal lobule (IPL) but decreased reactivity in the superior temporal gyrus (STG) and
the cerebellum. The high complexity of these neuroimaging findings again underlines our caution in not assuming the
generalizability of these results to other systems of emotional response.
4.2. Conclusions
Clinical scientists have increasingly recognized the importance of emotion to understanding psychopathology
(Kring & Bachorowski, 1999; Rottenberg & Johnson, 2007). Given this wide interest, the field has been surprisinglyslow to undertake quantitative reviews of emotional reactivity in Axis-I disorders. This report, as the first quantitative
review of emotion reactivity in major depression, begins to address this gap by suggesting that changes in emotional
reactivity are a reliable correlate of MDD. In addition to augmenting the clinical description of MDD as a disorder of
emotion, these analyses have implications for interventions designed to treat and prevent MDD. For example, to the
extent that diminished emotional reactivity is a key affective deficit in MDD, it may be the case that individuals who
strongly exhibit this deficit will have a more pernicious course of disorder (e.g., Rottenberg, Wilhelm et al., 2002). This
logic would also support the development of psychologically-based and pharmacological treatment techniques to
bolster MDD patients' appropriate reactivity to both positive and negative emotional stimuli. In fact, given the
centrality of affective disturbance in MDD, developing an accurate, system-by-system account of how MDD alters
emotional reactivity, including testing hypothesized proximal mechanisms (e.g., individual differences in cognition or
biological functioning), is a sine qua non for developing more effective, targeted treatments for this disorder. Wesubmit this meta-analysis as a modest first step towards this goal.
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