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Innovations in Drug Information Practice and Research 2015 Program Moderator: Patrick M. Malone, PharmD, FASHP Professor and Associate Dean of Internal Affairs The University of Findlay Disclosures The program chair and presenters for this continuing education activity have reported no relevant financial relationships. Announcements A LEAN Approach to Formulary Management Lauren Karel, PharmD, BCPS Ellena Anagnostis, PharmD, BCPS Cindy Wordell, PharmD, BCPS, FASHP Thomas Jefferson University Hospital Philadelphia, PA Objectives Recognize necessary steps when coordinating the addition or removal of a formulary drug Identify examples of Lean initiatives that can be applied to processes within health care Recommend Lean strategies for optimizing the formulary management process What is Lean? 1,2 Performance improvement methodology Popularized by the Toyota Motor Corporation Optimized value within each step of a process  Increased efficiency Improved quality Customer satisfaction Waste reduction Decreased turnaround times Innovations in Drug Information Practice and Research 2015 2015 Midyear Clinical Meeting & Exhibition © 2015 American Society of Health-System Pharmacists 1 of 22

A LEAN Approach to Formulary Management Announcements · 5S A lean tool used to optimize organization and reduce waste ... completion of items on the checklist ... Sullivan P, Soefje

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Innovations in Drug Information Practice and Research 2015

Program Moderator:Patrick M. Malone, PharmD, FASHP

Professor and Associate Dean of Internal AffairsThe University of Findlay

Disclosures

The program chair and presenters for this continuing education activity have reported no relevant financial relationships.

Announcements

A LEAN Approach to Formulary Management

Lauren Karel, PharmD, BCPS

Ellena Anagnostis, PharmD, BCPS

Cindy Wordell, PharmD, BCPS, FASHP

Thomas Jefferson University Hospital

Philadelphia, PA

Objectives

Recognize necessary steps when coordinating the addition or removal of a formulary drug

Identify examples of Lean initiatives that can be applied to processes within health care

Recommend Lean strategies for optimizing the formulary management process

What is Lean?1,2

Performance improvement methodology

Popularized by the Toyota Motor Corporation

Optimized value within each step of a process Increased efficiency

Improved quality

Customer satisfaction

Waste reduction

Decreased turnaround 

times

Innovations in Drug Information Practice and Research 2015 2015 Midyear Clinical Meeting & Exhibition

© 2015 American Society of Health-System Pharmacists 1 of 22

Lean methodology in healthcare

Focus area Lean initiatives

Inpatient sterile products3

• Implementation of standardized workflow, redistribution of duties, and visual control helped reduce missing doses, errors, and waste.

Pediatric IV and oral medications4

• Assessed floor plans, workflow, and patient movement data to determine optimal batch and delivery times.

Oncology infusion center5

• Targeted order verification, compounding, and delivery to improveworkflow.

CRRT preparation and delivery6

• Pharmacy technician workflow was standardized and included generation of reports specifying CRRT flow rates.

Considerations when updating the formulary status of a medication

•Wholesaler vs direct vs specialty pharmacy?

• What dosage forms will be carried?

• Where will the medication be stocked and/or dispensed?Procurement

• Is this medication included in any order sets?  

• Are pop‐up alerts needed?

• Can this interface with other automated systems?

Informatics /Technology

• Is this medication restricted to a specific area or service?

• Do any medication use policies need to be updated?

• How do we notify hospital staff of this change?Drug Information

Can lean methodology be used to improve efficiency with formulary management?

Which of the following is a question that should be considered when onboarding a drug recommended for formulary addition?

Will this medication be stocked in automated dispensing cabinets?If using smart pumps, what are the maximum/minimum infusion rates?Is this drug associated with a REMS program?All of the above

Thomas Jefferson University Hospital

900‐bed tertiary academic medical center

Three campuses

Main campus in Center City Philadelphia

Jefferson Hospital for Neuroscience

Methodist Hospital in South Philadelphia

Drug Information Center provides support for P&T Committee activities

Tools/Terms used in Lean methodology

Term Definition

Going to the Gemba

Going to the location where a specific process occurs to perform a walk‐through with individuals who are directly involved in the process.

Kaizen event Implementation of a rapid improvement project to achieve a desired future state.

Value‐stream mapping

A structured diagram to document the flow of activities within a specific process.  Within the diagram, steps are differentiated between value adding and non‐value adding. 

Visual management

Use of visual signals, such as colors or tracking boards, to facilitate identification of problems within a specific process. 

5S A lean tool used to optimize organization and reduce waste in a given area or process:• Sort – Remove unnecessary items• Store – Organize the area• Shine – Maintain a clean environment• Standardize – Maintain consistency• Sustain – Ensure continued use of the first four steps

Innovations in Drug Information Practice and Research 2015 2015 Midyear Clinical Meeting & Exhibition

© 2015 American Society of Health-System Pharmacists 2 of 22

Value‐stream mapping1

Value‐adding

• Changes the product or service

• Performed correctly

• Passes the ‘am I willing to pay for this?’ test

Non‐value adding by necessary

• Does not satisfy the ‘value‐adding’ criteria

• Required for regulatory purposes

Non‐value adding

• Does not satisfy the ‘value‐adding’ criteria

• Targets for Kaizen events

Formulary addition process

Formulary change 

requested

Monograph developed

Subcommittee reviews 

monograph

P&T / MEC make final decision

DIC emails updates to pharmacy 

staff

Informatics / Purchasing review pending 

medications

Informatics creates CPOE changes and performs interface 

testing

Await additional information and billing codes

Medication purchased and quarantined for 

barcode scanning

Prescriber orders 

medication

P&T: Pharmacy and Therapeutics Committee; MEC: Medical Executive Committee; DIC: Drug Information Center

Which steps in the formulary addition process could be considered 

non‐value adding?

P&T / MEC approves a medication for formulary additionInformatics team builds the medication order in CPOEApplicable policies are not updated, increasing the risk of a medication errorMedication is purchased and scanned to allow barcode recognition

Formulary addition process

Formulary change 

requested

Monograph developed

Subcommittee reviews 

monograph

P&T / MEC make final decision

DIC emails updates to pharmacy 

staff

Informatics / Purchasing review pending 

medications

Informatics creates CPOE changes and performs interface 

testing

Await additional information and billing codes

Medication purchased and quarantined for 

barcode scanning

Prescriber orders 

medication

P&T: Pharmacy and Therapeutics Committee; MEC: Medical Executive Committee; DIC: Drug Information Center

Standardized monograph: IV compounding information

Addition of an appendix with supplemental information to complete

**Only to be completed if drug is recommended for addition at the subcommittee level**

Parameter Recommendation Minimum/maximum doses for each proposed indication

Minimum/maximum infusion rates, if applicable

Admixture

BUD (with storage requirements)

Additional requirements

Filter Protect from light (amber bag) Special tubing Auxiliary labels: ___________________

Standardized monograph: Procurement information

Parameter Recommendation Estimated number of patients per year that would potentially receive this medication

Cost per patient per dose

Cost per patient per treatment course

Cost per patient per treatment course X estimated # patients

Additional lab tests, imaging, or other diagnostic testing required

Is there a patient assistance program?

Managed care access Prior authorization required

Drug purchasing/availability

Wholesaler (ABC) Specialty pharmacy Direct from manufacturer Other:_____________________

Alternative therapies (include budget impact analysis as above)

Innovations in Drug Information Practice and Research 2015 2015 Midyear Clinical Meeting & Exhibition

© 2015 American Society of Health-System Pharmacists 3 of 22

Standardized monograph:Considerations for CPOE

Parameter Recommendation

Dose calculation request

Amount/day:_________________ Amount/dose:_________________

Monograph and/or alert requests

Creating a checklist

Use of SharePoint Online (Microsoft, Redmon, WA) to track completion of items on the checklist

Accessible by key stakeholders 

Visual management used to identify completed actions, actions requiring additional work needed, and pending actions

Drug name Examplemorphone Exampleconazole Exampletuzumab

DEA schedule II N/A N/A

Subcommittee/P&T decision

Add  Add Add with restriction

Procurement Wholesaler Wholesaler Specialty

Safe handling instructions

N/A Updated Updated

Policy updatesrequired

Completed Completed Completed

Alerts in CPOE Completed Pending Pending

Automation interface testing

Pending Pending Pending

Memos drafted Pending Pending Pending

Creation of a Formulary Maintenance Committee

Composed of members from Drug Information, Informatics, Technology, Purchasing, and P&T Subcommittee Secretaries

Monthly ‘huddle’ via conference phone line to track status of completing steps on the checklist

Encourages direct communication with key individuals responsible for steps within the formulary management process

Practice reflection

How does your organization track formulary decisions?

Are there opportunities to reduce wasteful steps in formulary management?

Future directions

Collect data to analyze efficiency within each step

Identify a mechanism for establishing automatic prompts following completion of each step

Improve communication to hospital staff

Leverage concurrent department projects to ensure the success of Lean initiatives

Innovations in Drug Information Practice and Research 2015 2015 Midyear Clinical Meeting & Exhibition

© 2015 American Society of Health-System Pharmacists 4 of 22

Key takeaways

Lean methodology can be used in various aspects of pharmacy practice to improve efficiency with completing a process

• Not just operational activities!

Staff buy‐in is crucial when enacting changes

Application of Lean process improvement strategies must be an ongoing process

References

1. Graban M. Lean Hospitals: Improving Quality, Patient Safety, and Employee Engagement. 2nd ed. New York, NY: CRC Press; 2011.

2. Lawal AK, et al. Lean management in health care: definition, concepts, methodology and effects reported (systematic review protocol). Syst Rev. 2014;3:103. 

3. Hintzen BL, Knoer SJ, Van Dyke CJ, Milavitz BS. Effect of lean process improvement techniques on a university hospital inpatient pharmacy. Am J Health Syst Pharm. 2009;66(22):2042‐2047.

4. Bledsoe S, Little J, Wilkinson RS, Mick A. Using lean methodology to improve operational and clinical efficiency. Am J Health Syst Pharm. 2013;70(17):1476‐1477. 

5. Sullivan P, Soefje S, Reinhart D, McGeary C, Cabie ED. Using lean methodology to improve productivity in a hospital oncology pharmacy. Am J Health Syst Pharm. 2014;71(17):1491‐1498.

6. Benfield CB, Brummond P, Lucarotti A, et al. Applying lean principles to continuous renal replacement therapy processes. Am J Health Syst Pharm. 2015;72(3):218‐223.

Use of Flipped Classroom Approach for Teaching Drug Literature Evaluation

Robert D. Beckett, PharmD, BCPS

Assistant Professor of Pharmacy Practice

Director of the Drug Information Center

Manchester University College of Pharmacy

Objectives

At the end of the presentation, participants should be able to: 

1. Define flipped classroom in the context of other approaches to active learning

2. Recall results from the assessment of student performance and perceptions using this approach, and 

3. Identify lessons learned using this approach.

Discussion

With the participants sitting around you, identify and define one active learning approach you could use to teach drug literature evaluation.

Objective 1

Active Learning Approaches

Lecture Incorporating Activities

Team‐Based Learning

Problem‐Based Learning

Flipped Classroom

Innovations in Drug Information Practice and Research 2015 2015 Midyear Clinical Meeting & Exhibition

© 2015 American Society of Health-System Pharmacists 5 of 22

Drug Literature Evaluation at Manchester

Curriculum

• PHRM 322 (Drug Information)

• PHRM 420 (Drug Literature Evaluation)

• PHRM 530 and 531 (Pharmacy Practice Laboratory)

PHRM 420

• Clinical Trial Evaluation

• Biostatistics

• Additional Study Designs

• In‐Class Article Discussions

Bloom’s Taxonomy

Anderson LW, Krathwohl DR, eds. A Taxonomy for Learning, Teaching, and Assessing: A Revision of Bloom’s Taxonomy of Educational Objectives (Complete Edition). New York, NY: Longman Publishing Group; 2000.

Create

Evaluate

Analyze

Apply

Understand

Remember

Flipped Classroom at Manchester

Explanation

Demonstration

Practice

Feedback

Evaluation

In‐Class Activities

Example – Goals

Course Outcome

• Explain and assess the biostatistics used in a piece of primary literature.

Learning Objectives

• Classify an analysis as per protocol, intention to treat, modified intention to treat, or as treated.

• Explain why an investigator might select each of the data analysis strategies above.

Example – Explanation

Intention to treat: This type of analysis includes all patients who are randomized in the study. Using the above example, we would analyze all 250 patients regardless of completion. This is considered to be more conservative and “real world” (as so many patients are not compliant with treatment) and, as such, maximizes external validity. It is also is super cool because it allows investigators to preserve power, even when patients disappear from the study. This approach is USUALLY but not ALWAYS preferred in clinical trials. We will surely talk about this all semester long because it’s a really fun topic (are you excited as I am?!).

Example – Demonstration, Practice, Feedback

Innovations in Drug Information Practice and Research 2015 2015 Midyear Clinical Meeting & Exhibition

© 2015 American Society of Health-System Pharmacists 6 of 22

Example – Demonstration, Practice, Feedback Example – Evaluation

A clinical trial compares randomizes patients to six months of treatment with one of two anticoagulants. The group assessed for the primary endpoint includes all patients who received at least one dose of study medication regardless of attrition. This approach is best classified as:

• As treated

• Intention‐to‐treat

• Modified intention‐to‐treat

• Per protocol

In two to four sentences, explain TWO REASONS why use of intention to treat is preferred over per protocol in a superiority RCT comparing two antihypertensives for blood pressure reduction. 

Assessment – Perceptions

0%

20%

40%

60%

80%

100%

HandoutsEnhancedLearning

Handoutswere

Essential

ConsistentReview

ActivitiesEnhancedLearning

Activitieswere

Essential

ConsistentParticipation

Strongly Agree or Agree Neutral Disagree or Strongly Disagree

Assessment – Perceptions

0%

20%

40%

60%

80%

100%

Attention Engagement Enjoyment Interest Learning Retention

Compared to a traditional lecture, the flipped classroom approach positively impact my:

Strongly Agree or Agree Neutral Strongly Disagree or Disagree

Assessment – Perceptions

I prefer a flipped classroom over a traditional lecture:

Strongly Agree or Agree Neutral Strongly Disagree or Disagree

Next Step

Additional Study Designs

Year 1 vs. Year 2

Performance Assessment

Innovations in Drug Information Practice and Research 2015 2015 Midyear Clinical Meeting & Exhibition

© 2015 American Society of Health-System Pharmacists 7 of 22

Based on your experiences, do you expect that student performance improved from Year 1 to 

Year 2?

Yes, for Non‐Inferiority Trials

Yes, for Meta‐Analysis

Yes, for Both 

No, Neither Improved

Objective 2

Assessment – Performance

0%

20%

40%

60%

80%

100%

Non‐InferiorityAppropriate?

HypothesisTesting

Pick a Non‐InferiorityMargin

Interpret Non‐Inferiority

ITT vs. PP

Multiple Choice, Non‐Inferiority

Year 1 Year 2P < 0.001 P < 0.001 P < 0.001 P = 0.098 P = 0.35

Assessment – Performance

0%

20%

40%

60%

80%

100%

Heterogeneity Inter‐RaterReliability

I2 Publication Bias

Multiple Choice, Meta‐Analysis

Year 1 Year 2

P < 0.001 P = 0.046 P = 0.35 P = 0.018

Assessment – Performance

0

0.5

1

1.5

2

2.5

3

Biocreep Sources of UnpublishedData

Interpret Funnel Polt

Short Answer

Year 1 Year 2

P = 0.014 P = 0.018 P < 0.001

Discussion

With the participants sitting around you, identify 1) a lesson you have learned from using active learning to teach drug literature evaluation concepts and 2) how you have subsequently adjusted your approach.

Objective 3

Lessons Learned

Lesson Adjustment

Lack of participation in discussion Pod‐style seating

Inconsistent reading Readiness assessment quizzes

Learning objective rigor Peer review

Variable speed getting through class Extend time and prepare extra examples

Innovations in Drug Information Practice and Research 2015 2015 Midyear Clinical Meeting & Exhibition

© 2015 American Society of Health-System Pharmacists 8 of 22

Key Takeaways

Key Takeaway #1

• Consider increasing the amount of active learning in your drug literature evaluation course (lecture  lecture with activities; lecture with activities  flipped classroom)

Key Takeaway #2

• Use of flipped classroom resulted in positive student perceptions and a switch from lecture with activities to flipped classroom resulted in improved performance.

Key Takeaway #3

• Be comfortable with spontaneity and incorporate strategies to encourage active participation.

Use of Flipped Classroom Approach for Teaching Drug Literature Evaluation

Robert D. Beckett, PharmD, BCPS

Assistant Professor of Pharmacy Practice

Director of the Drug Information Center

Manchester University College of Pharmacy

Questions, Answers and Discussion Development, Implementation, and Impact of a Mobile Application to Request Drug 

Information

Scott Perkins, PharmDCo‐Director, Drug InformationClinical Assistant Professor

Campbell University College of Pharmacy & Health Sciences

Objectives

• Describe aspects important to consider when developing a drug information mobile application (app)

• Discuss strategies for implementing a drug information mobile app

• Describe how a drug information mobile app may impact a drug information center

Campbell Drug Information Center

• Created in 1987 from a grant from GlaxoSmithKline

• Free service for faculty, alumni, students and other healthcare providers

• 2 Co‐Directors, 4 fourth‐year student pharmacists, 1 Program Manager

• Currently receive 180‐250 requests on a monthly basis

40‐50% are literature requests

Innovations in Drug Information Practice and Research 2015 2015 Midyear Clinical Meeting & Exhibition

© 2015 American Society of Health-System Pharmacists 9 of 22

DIC Inquiries 1989‐2014 Request Categories in 2014

Mobile devices

• Increase in mobile device use

• May 2015: More Google searches on mobile devices than computers1

• Mobile drug information resources

• Used frequently by medical professionals2

Some reports indicate up to 75% of medical professionals access medical information through mobile devices several times a week or more

1. Dischler J. Building for the next moment. Inside AdWords.2. Boruff JT, Storie D. J Med Libr Assoc. 2014;102(1):22‐30.

Mobile App for Drug Information

• Positives: 

Speed

Instantly request information 

Convenience

Request information from anywhere

Photographs

Easy to provide photographs of pills, medication list, etc.

Activity

• Please take out your mobile device and pull up your text messaging service

• Type the following message:

• Is there any documentation to support a drug‐drug interaction between quetiapine and tiotropium? Our electronic database, “Drug N‐site Database,” indicates this is a category‐X interaction.

Mobile App for Drug Information

• Negatives: 

Potential for errors 

Incorrectly spelled words

Autocorrect

Minimal information provided

May limit amount of circumstantial information

“Hey how u mix apap 4 iv thx”

Outdated software or limited space on device

Innovations in Drug Information Practice and Research 2015 2015 Midyear Clinical Meeting & Exhibition

© 2015 American Society of Health-System Pharmacists 10 of 22

Development

• Development began in Fall 2013

• Intent:

1) Increase request volume

2) Provide a more convenient method to request information

Development

• Trial testing: May to August 2014

Ensured all features worked properly  Photograph function

Buttons

Check boxes

Ensured requests input into the app were appropriately formatted in request form 

Improved usability of user interface 

Campbell DIC Implementation

• Marketing Stage 1

Sep. 2014: Faculty, students, and alumni

• Marketing Stage 2

Nov. and Dec. 2014: Statement added to signature of our email responses

• Marketing Stage 3

Jun. 2015: Direct marketing to requesters on file

App Downloads by Month

0

10

20

30

40

50

60

Number of Download

s

Month

• Total downloads: 291

0

2

4

6

8

10

12

Number of Requests

Month

Requests through Mobile App(September 2014 through September 16th, 2015)

• Total requests: 39

• Individual users: 17

Repeat users: 7

‐Through

 16th

Marketing Stage 3

141

162    162   180    237    207   188    

216  306  180

170    204     

Innovations in Drug Information Practice and Research 2015 2015 Midyear Clinical Meeting & Exhibition

© 2015 American Society of Health-System Pharmacists 11 of 22

Impact(Request Volume)

Requests from New App Users Before and After Marketing Stage 3

0

1

2

3

4

5

6

7

8

9

10

Requester 1 Requester 2 Requester 3 Requester 4 Requester 5 Requester 6 Requester 7 Requester 8

Number of Req

uests

Requestsprior todownloadRequestswith app

• New requests after marketing stage 3 (June)

• Data from 3 months prior and 3 months after

All requests prior to June

App requests after June

Impact(Request Categories via Mobile App)

Categories Amount Categories AmountLiterature Requests 11 Drug‐drug Interactions 2Therapeutics 13 Drug‐lab interactions 2General Product Information

4 Herbal Products 1

Dosage Form 1 Pharmacokinetics 1Dosage 1 Toxicity 2Drug Stability 1• Literature requests

App: 28%

Traditional methods: 51% (during 2014)

• Variety

Categories via Application

Categories via Traditional Methods (2014)

Literature Requests

Therapeutics

General Product Information(GPI)

Impact(Request Category Comparison)

Literature Requests

GPI

Impact (Request Complexity)

• Complexity of request (excludes literature requests)

Time spent on requests: 

Traditional methods: 107 minutes per request

Mobile application: 161 minutes per request

• Background information given (excludes literature requests)

Words per request:

Online request form: 64 words per request

Mobile Application: 66 words per request

Limitations

• Limited number of requests to fully assess app

• Android vs iOS

• iOS 7 required

• Immediate drug information resource vs request tool

Future Plans

• Improvement:

Survey those who have used the app

• Marketing:

Marketing directed at preceptors of our students

Annual or bi‐annual marketing to those who have used our service

• Expansion:

Future services through the app

Consider Android app

Innovations in Drug Information Practice and Research 2015 2015 Midyear Clinical Meeting & Exhibition

© 2015 American Society of Health-System Pharmacists 12 of 22

Conclusion

• Minimal impact on total number of requests

• Appears to have improved convenience for some requesters

• Given time, the trend in initial data indicates this will likely have an impact on the volume of requests we receive in the future without sacrificing quality of requests we receive

Still assessing the degree of this impact

Acknowledgements

• Connie Barnes, PharmD

Vice Chair of Pharmacy Practice

Co‐Director of Drug Information

Professor of Pharmacy Practice

Campbell University College of Pharmacy & Health Sciences

• Ted Hancock, PharmD, CGP, BCACP, CPP, FASCP

Assistant Professor of Pharmacy Practice

Campbell University College of Pharmacy & Health Sciences

References

1. Dischler J. Building for the next moment [internet]. Inside AdWords. Google, Inc. 2015 May 5. [updated 2015 May 5, cited 2017 Sept 7]. Available from: http://adwords.blogspot.com/2015/05/building‐for‐next‐moment.html.

2. Boruff JT, Storie D. Mobile devices in medicine: a survey of how medical students, residents, and faculty use smartphones and other mobile devices to find information. J Med Libr Assoc. 2014;102(1):22‐30.

Everyone is a Winner: Leveraging your EMR to Optimize Formulary Restriction Compliance

Genevieve (Jeni) Hayes, PharmD, MSPharm, BCPS

Clinical Specialist, Outcomes Management

MUSC Health

Charleston, South Carolina

Objectives

Understand strategies for restricting medications on an institution formulary

Compare approaches for presenting medication restriction information in the electronic medical record (EMR)

Assess adherence to formulary restrictions in one’s organization

Our Charge

Ensure appropriate use of medications throughout the organization

Innovations in Drug Information Practice and Research 2015 2015 Midyear Clinical Meeting & Exhibition

© 2015 American Society of Health-System Pharmacists 13 of 22

Restriction Overview

Many health systems place restrictions on certain formulary medications to improve the appropriateness of their use

• Antimicrobial resistance

• High‐cost medications

• Serious safety concerns

J Managed Care Spec Pharm. 2014;20(7):677‐84.

Am J Hosp Pharm. 1982;39(11):1898‐901.

How many audience members have at least 1 formulary medication restricted in some manner?

Yes

No

Standardize restriction language

Ensure restriction criteria are objective 

Build EMR functionality

Assess adherence to formulary restrictions

Phase 1: Standardize Language

Phase 1: Standardize Language

Consistency among types 

• Service

• Location

• Provider type (eg, Attending, Fellow)

• Indication

• Miscellaneous

Word document  Online database

Phase 1: Standardize Language

Innovations in Drug Information Practice and Research 2015 2015 Midyear Clinical Meeting & Exhibition

© 2015 American Society of Health-System Pharmacists 14 of 22

Phase 2: Ensure Objective Criteria Phase 2: Ensure Objective Criteria

Review of all mediations restricted by indication

• Streamline vague or unclear criteria

Confirm intent of service and level of provider restrictions

• Actually ordered by a service or just recommended?

Phase 3:Build EMR Functionality

Phase 3: EMR Functionality

Multi‐faceted approach to optimizing adherence to formulary restricted medications

• Side bar information

• Cascading questions

• Order panel 

• Order set for complex restrictions

• Alternative alerts 

• Dual prescriber signature requirements

Side Bar Information

Before

• Hyperlink above the ordering information that must be clicked to expand the entire restriction text

© 2015 Epic Systems Corporation. Used with permission.

Side Bar Information

After

• Custom refreshable report that can be formatted and include hyperlinks

© 2015 Epic Systems Corporation. Used with permission.

Innovations in Drug Information Practice and Research 2015 2015 Midyear Clinical Meeting & Exhibition

© 2015 American Society of Health-System Pharmacists 15 of 22

Cascading Questions

Additional follow‐up questions appear depending on the answer that is selected

© 2015 Epic Systems Corporation. Used with permission.

Order Panel

Presents restriction text in full at the top of the panel

Allows multiple medications to be listed with different defaults for each option, but only one can be selected

© 2015 Epic Systems Corporation. Used with permission.

Order Set

Must be searched in a different field than individual medications

Allows multiple groups, both medications as well as other orders (eg, lab, nursing instructions, diet)

© 2015 Epic Systems Corporation. Used with permission.

Alternative Alert

Prevents provider with alternate options and allows ordering of those medications from that window

© 2015 Epic Systems Corporation. Used with permission.

Dual Prescriber Signature Requirements

Medication orders not sent for pharmacist verification until eligible second prescriber has signed

Concern for delays in care for time‐sensitive medications

Currently being developed for study protocols

Phase 4

Innovations in Drug Information Practice and Research 2015 2015 Midyear Clinical Meeting & Exhibition

© 2015 American Society of Health-System Pharmacists 16 of 22

Assessing Restriction Adherence

Medication use evaluations (MUEs)

• Individual agents (eg, albumin, IV acetaminophen)

• Classes of medications (eg, antiretrovirals)

Mechanisms

• Manual chart abstraction

• EMR documentation (interventions?)

Restricted medications should be built in the electronic medical record to 

make it easy to do the right thing and difficult to do the wrong thing.

True

False

Key Takeaways

Key Takeaway #1

• Having objective criteria facilitates evaluation of adherence to formulary restrictions.

Key Takeaway #2

• Multiple strategies in the electronic medical record can be used to inform clinicians and enforce formulary restrictions.

Key Takeaway #3

• Continuous assessment of your formulary can help ensure medication stewardship throughout one’s organization.

Questions, Answers and Discussion

Formulary Management Through SharePoint and InfoPath Tracking and Communication

Jamie M. Gomes, PharmD, BCPS

Clinical Specialist, Drug Information

The Children’s Hospital of Philadelphia

Objectives

Evaluate tools available in Microsoft SharePoint and Microsoft InfoPath forms to aid in formulary management.

Identify opportunities for use of SharePoint and InfoPath for formulary management and documentation.

Innovations in Drug Information Practice and Research 2015 2015 Midyear Clinical Meeting & Exhibition

© 2015 American Society of Health-System Pharmacists 17 of 22

The Children’s Hospital of Philadelphia (CHOP)

CHOP Care Network

• Main Campus

535 inpatient beds

Outpatient services

Rehabilitation services

• Primary Care, Specialty Care, Ambulatory Surgery, CHOP Care Network Newborn and Pediatric Inpatient Care, Home Care

Therapeutic Standards Committee (TSC)

• Number of Drugs on Formulary: 693

Hospital Wide Drug Information

Electronic Formulary

CPOE medication orders/order sets

Clinical Pathways

Smart Pumps

Intranet

Policies/Procedures/Job Aids

• Hazardous Medications List

• High Alert Medications List

• Look‐alike sound‐alike List

Ketogenic Diet Database

Department of Pharmacy Services

5 production/dispensing pharmacies

• 24 hour pharmacy 

• Oral Preparation

• Anesthesia/TPN

• Emergency Department

• Oncology Clinic

Pyxis MedStations

Sterile Products

• Robotic IV Automation (RIVA)

• DoseEdge Pharmacy Workflow Manager

Non‐Sterile Products

• Swisslog Automated Tablet Packaging System

• Pentapack Unit Dosing Machine

• Extemporaneous Compounding

Formulary Change Involvement

Therapeutic Standards Committee

Drug Information Pharmacists

LexicompFormulary

Epic Willow/

Core Clinical

(5) Pharmacy Supervisors

(5) Distribution Pharmacies and Technology

Pyxis

GO LIVE

Question: How do you currently track formulary changes?

Paper Files

Shared Drive

Excel Spreadsheet

E‐mail

Microsoft SharePoint

Web platform for Microsoft Office Suite

@CHOP – Intranet Sites

Capabilities:

• Store, organize, share, and access information

• Calendars

• Social Feeds – Newsfeed/Blogs 

• Document Folders

• Libraries/Lists

Innovations in Drug Information Practice and Research 2015 2015 Midyear Clinical Meeting & Exhibition

© 2015 American Society of Health-System Pharmacists 18 of 22

Microsoft InfoPath

Customize forms in SharePoint Libraries and Lists

Browser enabled form templates

Creating forms:

• Editable layouts

• Fields and controls

• Basic calculations

• Conditional formatting

@CHOP Pharmacy Administration SharePoint Site

CHOP Databases

Residency Applications

Formulary Addendum Database

Formulary‐Informatics Tracking

Crush and Mix/IV for PO

Hazardous Medication Documents

Formulary Addendum Database (FAD)

Pulls information from InfoPath form

Used as a task list

FAD Form – Attaching Documents

The form does NOT replace documents summarizing efficacy and safety.

Focus: operational implementation and documentation

Innovations in Drug Information Practice and Research 2015 2015 Midyear Clinical Meeting & Exhibition

© 2015 American Society of Health-System Pharmacists 19 of 22

FAD Form Questions

Storage, preparation, dispensing

Purchasing Information

Hospital Policies/Procedures

• Dietary Supplements

• Hazardous Drugs

• Vesicant/Irritant

• Look a‐like sound a‐like

Other formulary information

• Restrictions

• Consent

• G6PD deficiency

• QT Prolongation

• REMS program

• Medication Absorption Site

FAD Form – Manage Rules

Conditional formatting

• If “yes” then...

• If “pending” then…

Targeted questions

• Limits length

• Limits skipping questions

Administrative Checklist

Checklist for each type of technology or pharmacy area

• Status: Pending/Complete/Not Applicable

Conditional formatting

Feeds to different views in SharePoint Library

Creates a task list specific to each supervisor

Track completion from all supervisors for Go‐Live Date

What do you need me to do?

Views

Workflow

Formulary Committee

Notify Supervisors to Check the FAD

Therapeutic Standards Committee

Follow‐up on Administrative 

ChecklistGo‐Live

Innovations in Drug Information Practice and Research 2015 2015 Midyear Clinical Meeting & Exhibition

© 2015 American Society of Health-System Pharmacists 20 of 22

Question: How do you think users at your institution would react to the introduction of InfoPath forms?

This is too much work.

How am I ever going to figure this out?

Thank goodness!

CHOP Databases

Formulary Addendum Database

Residency Applications

Formulary‐Informatics Tracking

Crush and Mix/IV for PO

Hazardous Medication Documents

Formulary/Informatics Tracking Formulary/Informatics Tracking

Drug Shortage View/Task list

Filtered based on

• Follow up needed? (Yes/No)

• Status

On Shortage – Unavailable

On Shortage – Restricted

Resolved

Crush and Mix/IV form PO Export to Excel

Columns in “View” can be exported

Example: Crush and Mix/IV form PO 

• Drug Name

• Formulary Recommendation

• Concentration

• Prepared by Location

• Dispensed from Location

Helpful for lists prone to updates

• Print

• Save

• Distribute

Innovations in Drug Information Practice and Research 2015 2015 Midyear Clinical Meeting & Exhibition

© 2015 American Society of Health-System Pharmacists 21 of 22

True or False: SharePoint is only useful if you design forms in 

InfoPath.

True

False

Discussion

Ideas for Use of SharePoint/InfoPath

Class Reviews

Drug information question documentation

Formulary addition requests

Removal from Formulary

Key Takeaways

Microsoft InfoPath is a program used to create browser enabled forms in Microsoft SharePoint.

Utilize fields and controls in Microsoft InfoPath to optimize questions and length of forms as well as to control “views” in Microsoft SharePoint.

Microsoft SharePoint can be a useful program to create checklists for items requiring follow up and to aid in communication and documentation of formulary changes.

Formulary Management Through SharePoint and InfoPath Tracking and Communication

Jamie M. Gomes, PharmD, BCPS

Clinical Specialist, Drug Information

The Children’s Hospital of Philadelphia

Questions, Answers and Discussion

Innovations in Drug Information Practice and Research 2015 2015 Midyear Clinical Meeting & Exhibition

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