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A family of matched parent-child HLA haplotypes:
A case study from Bahrain
Mariam Fida, MD, PhD Director | PGD
Consultant| Medical Genetics
GCC Forensics Conference & Exhibition 14.Nov.2019
HLA Typing
Match patient & donors for bone marrow, cord blood or organ transplants
HLA Complex
HLA Typing
Relatives of patient
Relatives of patient
Relatives of patient
100% match
Human Identification Test
Mother
Son
Human Identification Test
Mother
Son
Consanguinity
Extended family pedigree
Family Haplotypes
Conclusion
Sickle Cell Carrier
Sickle Cell Affected
Sickle Cell Disease
Sickle Cell Carrier
PGT
Hemophilia
Sickle Cell Disease
Colon Cancer
Breast Cancer
SCID
↓G6PD
Phynelketonuria
α-Thalassemia
β-Thalassemia
Cystic Fibrosis
Down Syndrome
Fragile X Spinal Muscular Atrophy
Polycystic Kidney Disease
A test performed to analyze the DNA from oocytes or embryos for HLA-typing or for determining genetic abnormalities
Sickle Cell Carrier
Sickle Cell Affected
Sickle Cell Disease
Sickle Cell Carrier
Sickle Cell Carrier
Sickle Cell Affected
Sickle Cell Disease
Sickle Cell Carrier
Healthy unaffected
Sickle Cell Carrier
Sickle Cell Affected
Sickle Cell Disease
Sickle Cell Carrier
Healthy unaffected
HLA match to affected sibling
IVF
PGT
PGT - M
(day 3)
IVF
PGT
PGT - M
(day 3)
IVF
PGT
PGT - M
(day 3)
IVF
PGT
PGT - M
(day 3)
Transfer into mother
Acknowledgment
Ryan Ed Bangate
Ferdinand Webnda
Arnold A. Villanueva
PGT Team
Thank you!