CURRICULUM VITAE Howard M. Eisenberg, M.D.

R.K. Thompson Professor and Chairman, Department of Neurosurgery University of Maryland School of Medicine

November 7, 2011 Department of Neurosurgery University of Maryland School of Medicine and Medical Systems 22 South Greene Street, Room S12D10A Baltimore, Maryland 21201 (410) 328-3514 / FAX (410) 328-0756 EDUCATION 1956 - 1960 B.A., Syracuse University, Syracuse, New York 1960 - 1964 M.D., State University of New York, Downstate Medical Center, New York,

New York INTERNSHIP, RESIDENCY AND FELLOWSHIP 1964 - 1966 Intern, Resident and Assistant Surgeon, General Surgery, New York Hospital,

New York, New York 1965 - 1966 Fellow in Surgery, Cornell University, New York, New York 1966 - 1970 Resident, Neurological Surgery, Children's Hospital Medical Center and Peter

Bent Brigham Hospital, Boston, Massachusetts 1967 - 1968 Fellow in Neurology, National Hospital for Nervous Disease, Queen Square,

London, England. (6 months) 1969 - 1970 Clinical Fellow in Surgery, Harvard Medical School, Boston, Massachusetts BOARD CERTIFICATION 1973 Diplomate, American Board of Neurological Surgery

CURRICULUM VITAE 2 Howard M. Eisenberg, M.D. LICENSURE

Maryland Texas Massachusetts New York MILITARY SERVICE 1970 - 1972 LCDR USNR Active Duty, Neurosurgeon

Chief of Department of Neurosurgery, Naval Hospital, St. Albans, New York (1971-72).

FACULTY POSITIONS 1972 - 1975 Instructor of Surgery (Neurosurgery), Harvard Medical School Boston,

Massachusetts; Junior Associate, Neurosurgery, Peter Bent Brigham and Children's Hospital Medical Center, Boston, Massachusetts

1973 - 1975 Consultant in Neurosurgery: Boston Hospital for Women; Robert Breck Brigham

Hospital; Veteran's Administration Hospital; Pondville Hospital; Massachusetts Hospital School, Massachusetts

1975 - 1977 Assistant Professor of Surgery (Neurosurgery) and Pediatrics, Attending

Neurosurgeon and Head of Pediatric Neurosurgery, University of Texas Medical Branch, Galveston, Texas; Consultant in Neurosurgery, Mainland Center Hospital, Texas City, Texas, St. Mary's Hospital, Galveston, Texas

1977 - 1981 Associate Professor of Surgery (Neurosurgery) and Pediatrics, University of

Texas Medical Branch, Galveston, Texas 1980 - 1992 Chief of Neurological Surgery, University of Texas Medical Branch, Galveston,

Texas 1981 - 1992 Professor of Surgery (Neurosurgery) and Pediatrics, University of Texas Medical

Branch, Galveston, Texas 1992 - 1996 Professor and Head, Division of Neurological Surgery, University of Maryland

School of Medicine and Medical Systems, Baltimore, Maryland 1993 -1997 Director of Medical Services and Program in Trauma, R Adams Cowley Shock

Trauma Center, University of Maryland School of Medicine and Medical Systems, Baltimore, Maryland

CURRICULUM VITAE 3 Howard M. Eisenberg, M.D. 1995 - 1997 Director, Program in Trauma, R Adams Cowley Shock Trauma Center,

University of Maryland School of Medicine and Medical Systems, Baltimore, Maryland

1996 - 2000 Professor and Chair, Department of Neurosurgery, University of Maryland School

of Medicine and Medical Systems, Baltimore, Maryland 2000 - Present R. K. Thompson Professor and Chairman, Department of Neurosurgery,

University of Maryland School of Medicine and Medical Systems, Baltimore, Maryland

MAJOR CONSULTANT AND COMMITTEE MEMBERSHIP ACTIVITIES NATIONAL INSTITUTES OF HEALTH REVIEW GROUPS 1983 - 1987 Member, Neurology Study Section A 1987 - 1991 Chairman, Neurology Study Section A 2007 - Present Member, DSMB NINDS – CoolKids Trial AMERICAN BOARD OF NEUROLOGICAL SURGEONS Ex-officio member, Residency Review Committee for Neurosurgery (1990-1996) Representative, American Board of Medical Specialties (1990-1996) Secretary-Treasurer (1992-95) Chairman, Board of Directors (1995-96) ACCREDITATION COUNCIL FOR GRADUATE MEDICAL EDUCATION 1996 - 2002 Member Residency Review Committee for Neurosurgery 2001 - 2002 Vice Chair Residency Review Committee for Neurosurgery 2004 - Present Member Appeals Panel Neurosurgery EDITORIAL BOARDS 1984 - 1988 Editorial Board, Journal of Central Nervous System Trauma, Mary Ann Liebert, Inc. 1985 - 1990 Editorial Board, Brain Injury, College Hill Press, San Diego, Taylor & Francis

Ltd., London (International). 1985 - 1990 Consulting Editor, Brain Injury and Recovery (Serial), The Guilford Press, New York. 1988 - 1993 Editorial Board, Journal of Neurotrauma, Mary Ann Liebert, Inc. 1989 - 1999 Editorial Board, Journal of Neurosurgery 1990 - Present Editorial Board, Critical Reviews in Neurosurgery

CURRICULUM VITAE 4 Howard M. Eisenberg, M.D. 1997 - 1999 Co-Chairman, Editorial Board, Journal of Neurosurgery 1999 - Present Editorial Advisory Board, Journal of Neurosurgery 2007 - Present Editorial Advisory Board, Neurosurgery 2009 - Present Editorial Advisory Board, World Surgery SOCIETY OF NEUROLOGICAL SURGEONS 1989 - 1990 Chairman, Program Committee 1990 - 1993 Executive Council Member at Large 1991 - 1993 Chairman, Long Range Planning Committee 1993 - 1998 Chairman, Grass Award Selection Committee 1998 - 1999 Vice President 1999 - 2000 President-Elect 2000 - 2001 President 2001 - 2003 Member Executive Council 2002 - 2010 Representative to AANS/CNS Washington Committee 2008 Distinguished Service Award AMERICAN ACADEMY OF NEUROLOGICAL SURGERY 1999 - 2000 Chairman, Program Committee 1999 - 2000 Vice President AMERICAN ASSOCIATION OF NEUROLOGICAL SURGEONS/CONGRESS OF NEUROLOGICAL SURGEONS 1986 - 1990 Secretary-Treasurer, Joint Section on Trauma 1990 - 1993 Chairman, Research and Basic Science Sub-Committee 1990 Ad Hoc Scientific Advisory Committee, AANS "Decade of the Brain." 1991 - 1994 Member, Van Wagenen Fellowship Committee 1994 - 1995 Chairman, Van Wagenen Fellowship Committee 1995 - 1997 CNS Nominating Committee 2000 - 2003 AANS Nominating Committee AMERICAN COLLEGE OF SURGEONS 1990 - 1993 Member, Advisory Council for Neurological Surgery 1991 - 2000 Member, Committee on Trauma 1993 - 1997 Chairman, Advisory Council for Neurological Surgery 1997 Member, Nominating Committee of the Fellows (Officers and Governors of the

Fellows) 2000 Member, Committee on Surgical Education in Medical Schools RESEARCH COMMITTEES 1980 Steering Committee, National Spinal Cord Injury Study, NIH 1982 - 1989 Chairman, Steering Committee, National Coma Data Bank, NIH

CURRICULUM VITAE 5 Howard M. Eisenberg, M.D. 1995 - 1997 Chairman, Tirilazad SAH Safety and Monitoring Committee, UpJohn 1997 Member, Brain Injury Research Fund Blue Ribbon Panel of the Brain Injury

Association 2000 Council of Healthcare Advisors, Gerson Lehrman Group 2001 - 2006 New York State Spinal Cord Injury Research Bd Scientific Advisory Committee 2001 - 2006 Member of the Maryland State Spinal Cord Injury Research Board 2003 - 2008 Chair, DSMD Acetlion Aneurysm SAH Conscious I 2004 - 2011 DSMB CoolKids, NIH 2008 - Present Chair, DSMD Actelion Aneurysm SAH Conscious II 2008 - Present Chair, DSMB Insightec Focused Ultrasound MEMBERSHIP IN SCIENTIFIC AND PROFESSIONAL SOCIETIES: American Academy of Neurological Surgery (Vice President) American Association for the Advancement of Science American Association of Neurological Surgeons American Association of Neurological Surgeons, Section on Tumors, Section on Trauma (Sec.-Treasurer), Section on Pediatric Neurosurgery, Section on Basic Science (Chairman 1988-1989) American Board of Neurological Surgery (Member, Board of Directors (sec-treas-chair), 1990-1996) American College of Surgeons (Chair, Advisory Council for Neurological Surgery) American Epilepsy Society American Medical Association American Society for Pediatric Neurosurgery (Founding member) American Surgical Association Baltimore City Medical Society Congress of Neurological Surgeons Epilepsy Foundation of America Galveston County Medical Society International Society for Pediatric Neurosurgery Maryland Neurosurgical Society Massachusetts Medical Society Medical and Chirurgical Faculty of Maryland New England Neurosurgical Society New York Academy of Sciences North American Skull Base Society Research Society of Neurological Surgeons Rocky Mountain Neurosurgical Society Sigma Xi, The Scientific Research Society Society for Neuroscience Society of Neurological Surgeons (Vice President 1999, President 2000) Southern Neurosurgical Society Texas Neurosurgical Association

CURRICULUM VITAE 6 Howard M. Eisenberg, M.D. MEDICAL SCHOOL ACTIVITIES UNIVERSITY OF TEXAS MEDICAL BRANCH, GALVESTON, TEXAS

Intern Advisory Committee Neuroscience Course Committee Appointment, Promotion and Tenure Committee Curriculum Committee Chairman Search Committee for Chairman, Department of Anatomy Chairman, Search Committee for Chairman, Department of Pathology Search Committee for Chairman, Department of Psychiatry Search Committee for Chairman, Department of Ophthalmology Department of Surgery Executive Committee Ad Hoc Departmental External Review Committee, Department of Surgery

UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE AND UNIVERSITY OF MARYLAND MEDICAL

SYSTEMS, BALTIMORE, MARYLAND

School of Medicine Executive Committee Medical Executive Committee (UMMS) Council of Clinical Chiefs (UMMS) Chair, Finance Committee, University Physicians, Inc. Finance Committee (UMMS) Strategic Planning Steering Committee (past) Neuroscience Program Development Committee (past) Department of Surgery Executive Committee (past) Chairman, Shock Trauma Medical Executive Committee (past) Shock Trauma Senior Leadership Group (past)

Fiscal Affairs Advisory Committee (to the Dean) Chairman, Financial Committee, University Physicians Inc. (Practice Plans) HONORS AND AWARDS 1990 Wakeman Award, Duke University 1990 Honored Guest, Japanese Society of Neurotraumatology 1991 Lecture and Trauma Award (First), American Association of Neurological

Surgeons/Congress of Neurological Surgeons, Trauma, Joint Section on Trauma 1999 Michael Scott Lecturer, Philadelphia, PA 1994 William Fields Caveness Award, National Head Injury Foundation, Inc. 2002 Wagner Visiting Professor, Medical College of New Jersey 2002 Marshall Visiting Professor, University of Toronto 2003 Matson Visiting Professor, Harvard University 2005 19th Annual Eldridge Campbell Lecture, Albany Medical College 2008 Distinguished Service Award, Society of Neurological Surgeons

CURRICULUM VITAE 7 Howard M. Eisenberg, M.D. 2010 1st Alumni Visiting Professor, Department of Neurosurgery, Brigham and

Women’s Hospital, Harvard University 2011 Snodgras Visiting Professor, University of Texas Medical Branch TEACHING ACTIVITIES 1980 - 1992 Residency (Neurosurgery) Program Director, University of Texas Medical Branch 1992 - Present Residency Program Director, University Maryland School of Medicine 1996 - 1997 Neurosurgery Faculty Consultant on doctoral dissertation of Clair Johnson,

University of Maryland Baltimore County doctoral candidate: "A cognitive-linguistic approach to psychopathology in seizure disorders."

1996 - 1997 Member, doctoral dissertation committee of Joshua Lieberman, Johns Hopkins University School of Public Health doctoral candidate: "Association between apoliproprotein E4 and neuropsychologic recovery following traumatic brain injury."

CONSULTANT 1995 - 1997 UpJohn, Kalamazoo Michigan 2004 - 2007 BioAxone Therapeutique Line, Montreal Quebec 2005 - Present Actelion Pharmaceuticals Ltd., Allschwil Switzerland 2009 - Present Focused Ultrasound Surgery Foundation, Charlottesville, VA GRANT SUPPORT CURRENT: 2004 - 2013 Principal Investigator: Traumatic Brain Injury Clinical Trial Network. U01

HD42736 (NIH) $1,650,000 2008 - 2013 Principal Investigator: A Randomized Placebo-Controlled Treatment Study for

Moderate and Severe Traumatic Brain Injury. DOD and USAMRAA, $1,500.000. 2010 – 2013 Site Medical Monitor: Safety and Pharmacokinetics of Riluzole in Patients with

Traumatic Acute Spinal Cord Injury. Department of Defense and Christopher Reeve Foundation, Award # 0001-142-001.

2011 - 2013 Site Principal Investigator: ProTECT III: Progesterone for the Treatment of Traumatic Brain Injury. 1U01NS062778 (NINDS).

PAST: 1972 - 1974 NIH-NINCDS Special Fellowship.

CURRICULUM VITAE 8 Howard M. Eisenberg, M.D. 1975 - 1981 Co-Investigator: Center for the study of nervous system injury. DHEW NS 07377

(NIH). Program Project Grant. 1978 - 1982 Principal Investigator: A longitudinal study of infantile hydrocephalus. The

National Foundation-March of Dimes #6-173. 1979 - 1986 Principal Investigator: Comprehensive central nervous system trauma center.

DHHS NS 9-2314 NINCDS ($484,838). 1980 - 1982 Principal Investigator: National traumatic coma data bank network-pilot phase.

DHHS NS 9-2308 NINCDS. 1981 - 1985 Principal Investigator: Center for the study of nervous system injury. DHHS 5P01

NS 07377. NIH ($661,295). 1981 - 1986 Principal Investigator: Measurement of cerebral blood flow and evoked responses

in brain injury. Moody Foundation #80-233. ($300,000). 1983 - 1989 Principal Investigator: National traumatic coma data bank network-Main Phase.

NINCDS DHHS NS 3-2339. NIH. ($1,056,571). 1984 Principal Investigator (at site): National acute spinal injury study. NIH NS 15078

(Yale University). ($127,093). 1984 - 1986 Co-Investigator: Workshop on neurobehavioral recovery from head injury".

DHHS 1R13 NS 21633. ($26,121). 1984 - 1987 Co-Investigator: Reorganization of brain function in recovery from aphasia.

Dept. of Education #G008435031 (Peer review DOE). ($177,258). 1984 - 1988 Co-Investigator: Magnetic resonance imaging after severe head injury:

Relationship to outcome of rehabilitation. Moody Foundation #84-152 & #84-152A. ($91,668).

1984 - 1991 Co-Investigator: Neurobehavioral outcome of head injury in children.

NINCDS/NANCDS NS 21889-02 ($807,822). 1984 - 1986 Principal Investigator: A study of animal models of brain injury using

2-deoxyglucose autoradiography. Moody Foundation #84-99C. ($56,700). 1984 - 1987 Principal Investigator: A study of animal models of brain injury using

2-deoxyglucose autoradiography. Moody Foundation #84-99A. ($109,814). 1985 Hall Foundation: To purchase high field strength animal magnetic resonance

spectroscopy facility in the Neurosurgery laboratory. ($885,000).

CURRICULUM VITAE 9 Howard M. Eisenberg, M.D. 1985 Co-Investigator: Magnetoencephalographic study of reorganization of brain

function in recovery from aphasia in head injury patients. Mobility Foundation. ($231,535).

1985 - 1986 Principal Investigator: Effects of pharmacological and biological agents on motor

recovery following central nervous system injury. Moody Foundation #84-99B (Subcontract to Massachusetts Gen. Hosp. - L. Borges, PI). ($72,100).

1985 - 1991 Principal Investigator (at site): Randomized study: Dose Escalation Study of

U-74,006F in moderate and severe head injured patients. The University of Virginia. ($144,300).

1986 Co-Investigator: The effects of CDP-choline on the neurobehavioral sequelae of

mild and moderate closed head injury. Ferrer International, S.A. ($79,342). 1986 - 1989 Co-Investigator: Neural regulation of thirst. DHHS 1RO1 NS 23055-O1A1

(NIH). ($189,708). 1986 - 1988 Principal Investigator: Studies of animal models of brain injury: Neuronal

transplantation and hyperbaric oxygen. Moody Foundation #86-138. ($29,900). 1986 - 1988 Principal Investigator: Calcium currents in cerebrovascular cells: Relationship to

treatment in brain injury. Moody Foundation #86-139. ($29,409). 1986 - 1989 Principal Investigator: Investigations into factor determining regional cerebral

blood flow in coma: Level of consciousness, level of stimulation, cerebral blood volume. Moody Foundation #86-140. ($53,300).

1987 Principal Investigator (with Andrew C. Papanicolaou, Ph.D.):

Magnetoencephalography laboratory at transitional learning community. Moody Foundation #87-45. ($1,186,709).

1987 - 1990 Principal Investigator: Development of medical adjunctive treatment for acute

penetrating head injury. Dept. of Defense, U.S. Army. ($282,841). 1988 Co-Investigator: Behavioral imaging project. Biologic Systems Corp. ($13,000). 1988 - 1991 Co-Investigator: Randomized study of nicardipine in subarachnoid hemorrhage.

USPHS-NS24806 (subcontract) (NIH). (Funded on per patient basis). 1989 Co-Investigator: Superparamagnetic iron oxides as T2 relaxation enhancers for

magnetic resonance imaging. Advanced Magnetics, Inc. ($20,000).

CURRICULUM VITAE 10 Howard M. Eisenberg, M.D. 1989 Co-Investigator: Assessment of mechanisms of glutamate antagonists in focal

MCA occlusion in rats using MRI and 31P-spectroscopy. Hoffman-LaRoche, Inc. ($27,763).

1989 - 1991 Co-Investigator: Comparative studies of behavioral and cerebral functional

activity following nigral and adrenal medulla transplants and dopamine infusions in an animal model of Parkinsonism. Moody Foundation #88-64. ($167,060).

1989 - 1992 Co-Investigator: Neural regulation of thirst. (NIH) ($579,478). 1990 - 1992 Principal Investigator (UTMB) (Solomon H. Snyder, M.D., Johns Hopkins

University Principal Investigator): The study of a new neuronal cell line for transplantation. The Moody Foundation. ($544,869).

1991 - 1992 Co-Investigator: Randomized study: Dose Escalation Study of U-74,006F in

moderate and severe head injured patients. The University of Virginia. ($144,300).

1992 - 1998 Co-Investigator: Randomized, stratified, double-blind, multi-center study of

Sygen (GM1) versus placebo in treatment of acute spinal cord injury; #G1291-05. Fidia Pharmaceutical Corp. ($418,450).

1993 - 1994 Co-Investigator: A multicenter open label and randomized pilot trial of safety of

OPC-14117 in moderate head injury; #67-92-201. Otsuka. ($267,889). 1993 - 1994 Co-Investigator: A placebo controlled trial to evaluate the safety, tolerability, and

potential efficacy of initiating intravenous administration of CGS-19755 to serious head trauma patients prior to surgery; #05/3). Ciba-Geigy. ($105,000).

1993 - 1994 Co-Investigator: Tirilazad mesylate (U-74, 006F) in subarachnoid hemorrhage

(SAH); #P-2700-0029). Upjohn. ($164,700). 1993 - 1995 Co-Investigator: Head Injury Tirilazad Trial (HITT): A multi-center efficacy

study of Tirilazad Mesylate (U-74, 006F) in patients with moderate and severe head injuries; #P-2700-0017. Upjohn. ($252,665).

1993 - 1995 Co- Investigator: Neurobehavioral outcome of head injury in children; #2R01 NS

21889-10. NIH/NINDS. ($795,030). 1993 - 1996 Co-Investigator: Tirilazad Mesylate (U-74, 006F) & Methylprednisolone Sodium

Succinate (MPSS) in acute spinal cord injury; #P-2700-0028. Upjohn. ($185,370).

1993 - 1996 Principal Investigator 9/30/95 - 9/30/96, Co-Principal Investigator 4/15/93-

9/29/95: Neurobehavioral effects of traumatic brain injury in older adults;

CURRICULUM VITAE 11 Howard M. Eisenberg, M.D.

NIDRR/Emory University subcontract, field-initiated research grant H1333G30051. ($374,934).

1994 - 1995 Co- Investigator: Efficacy and Safety of Multiple Intravenous Bolus Injections of

5 mg/kg of CGS-19750 with Placebo Intubated Severe Closed Traumatic Brain Injured patients, Phase III. Ciba-Geigy ($153,288).

1996 - 1997 Co-Principal Investigator: Prospective, randomized, double-blind, placebo-

controlled, multicenter study to determine safety and efficacy of intravenously administered SDZ EAA 494 in hospitalized patients with severe traumatic brain injury; #EAA C351-E-00. Sandoz Pharmaceutical Corporation. ($75,000).

1998 - 2000 Co-Investigator: Double-blind, placebo-controlled, multicenter study to evaluate

the efficacy and safety of a single intravenous dose of CP-101,606 in subjects with severe head injury; #161-105. Pfizer Inc.

2009 - 2010 Site Principal Investigator: A Randomized, Double Blind, Placebo-Controlled

Dose Escalation Study to Investigate the Safety and Pharmacokinetics after Single and Multiple Doses of SLV334 in Sequential Cohorts of Patients with Moderate and Severe Traumatic Brain Injury; #S334.2.002. Solvay Pharmaceuticals.

PUBLICATIONS ARTICLES IN PEER-REVIEWED JOURNALS 1. Eisenberg, H.M.; Barlow, C.F.; Lorenzo, A.V. Effect of dexamethasone on altered brain

permeability. Arch. Neurol. 23:18-22; 1970. 2. Eisenberg, H.M.; Davidson, R.; Shillito, J. Lumbar peritoneal shunts: A review of 34 cases. J.

Neurosurg. 35:427-431; 1971. 3. Strand, R.; Eisenberg, H.M. Anterior sacral meningocele in association with Marfan's syndrome.

Radiology 99:653-654; 1971. 4. Habal, M.C.; McComb, J.G.; Shillito, J.; Eisenberg, H.M.; Murray, J.E. Combined cervical

posterior-anterior approach to the spinal foramen tumors. J. Neurosurg. 37:113-116; 1972. 5. Eisenberg, H.M.; McComb, J.G.; Lorenzo, A.V. Cerebrospinal fluid overproduction and

hydrocephalus associated with choroid plexus papilloma. J. Neurosurg. 40:381-385; 1974. 6. Eisenberg, H.M.; McLennan, J.E.; Welch, K. Ventriculospinal perfusion in cats with

kaolin-induced hydrocephalus. J. Neurosurg. 41:20-28; 1974.

CURRICULUM VITAE 12 Howard M. Eisenberg, M.D. 7. Eisenberg, H.M.; McLennan, J.E.; Welch, K.; Treves, S. Radioisotope ventriculography in cats

with kaolin-induced hydrocephalus. Radiology 110:399-402; 1974. 8. Lorenzo, A.V.; Hedley-Whyte, E.T.; Eisenberg, H.M.; Hsu, D.W. Increased penetration of

horseradish peroxidase across the blood-brain barrier induced by metrazol seizures. Brain Res. 88:136-140; 1974.

9. Hirose, G.; Lombroso, C.T.; Eisenberg, H.M. Thalamic tumors in childhood: Clinical, laboratory

and therapeutic considerations. Arch. Neurol. 32:740-744; 1975. 10. McComb, J.G.; Eisenberg, H.M.; Strand, R.D. Positional third ventricular deformity.

Neuroradiology 8:249-252; 1975. 11. Eisenberg, H.M.; Sarwar, M.; Schochet, Jr., S. Symptomatic Rathke's cleft cyst. Case report. J.

Neurosurg. 45:585-588; 1976. 12. Eisenberg, H.M.; Welch, K. Alteration of sodium conductance of feline choroid plexus: Effect of

2,4,6-triaminopyrimidine and tetrodotoxin. Brain Res. 107:645-649; 1976. 13. Eisenberg, H.M.; Suddith, R.L. Biochemical properties of brain capillaries. Surg. Forum

28:470-471; 1977. 14. Kelly, P.J.; Gorten, R.J.; Grossman, R.G.; Eisenberg, H.M. Cerebral perfusion, vascular spasm,

and outcome in patients with ruptured intracranial aneurysms. J. Neurosurg. 47:44-49; 1977. 15. Eisenberg, H.M.; Sarwar, M. Ventriculographic features of ascending transtentorial herniation.

Acta Neurochirurgica 42:225-228; 1978. 16. Eisenberg, H.M.; Suddith, R.L. Cerebral vessels have the capacity to transport sodium and

potassium. Science 206:1083-1085; 1979. 17. Eisenberg, H.M.; Turner, J.W.; Teasdale, G.; Rowan, J.; Feinstein, R.; Grossman, R.G.

Monitoring of cortical excitability during induced hypotension in aneurysm operations. J. Neurosurg. 50:595-602; 1979.

18. Kelly, P.J.; Gorten, R.J.; Rose, J.E.; Grossman, R.G.; Eisenberg, H.M. Radionuclide cerebral

angiography and the timing of aneurysm surgery. Neurosurgery 5(2):202-207; 1979. 19. Levin, H.S.; Eisenberg, H.M. Neuropsychological impairment after closed head injury in

children and adolescents. J. Pediatr. Psychol. 4:389-402; 1979. 20. Levin, H.S.; Eisenberg, H.M. Neuropsychological outcome of closed head injury in children and

adolescents. Child's Brain 5:281-292; 1979.

CURRICULUM VITAE 13 Howard M. Eisenberg, M.D. 21. Matusik, M.C.; Eisenberg, H.M.; Meyer, III, W.J. Gelastic (laughing) seizures and precocious

puberty. Am. J. Dis. Child 135:837-838; 1981. 22. Levin, H.S.; Eisenberg, H.M.; Wigg, N.R.; Kobayashi, K. Memory and intellectual ability after

head injury in children and adolescents. Neurosurgery 11(5): 668-673; 1982. 23. Thompson, M.G.; Eisenberg, H.M.; Levin, H.S. Hydrocephalic infants: Developmental

assessment and computed tomography. Child's Brain 9:400-410; 1982. 24. Levin, H.S.; Madison, C.F.; Dumanoir, C.B.; Meyers, C.A.; Eisenberg, H.M. Mutism after

closed head injury. Arch. Neurol. 40:601-606; 1983. 25. Marshall, L.F.; Becker, D.P.; Bowers, S.A.; Cayard, C.; Eisenberg, H.M.; et al. The National

Traumatic Coma Data Bank. Part 1: Design, purpose, goals, and results. J. Neurosurg. 59:276-284; 1983.

26. Meyers, C.A.; Levin, H.S.; Eisenberg, H.M. Early vs late lateral ventricular enlargement

following closed head injury. J. Neurol. Neurosurg. Psychiat. 46:1092-1097; 1983. 27. Papanicolaou, A.C.; Eisenberg, H.M.; Levy, R.S. Evoked potential correlates of left hemisphere

dominance in covert articulation: An auditory probe paradigm. Intern. J. Neurosci. 20:289-294; 1983.

28. Papanicolaou, A.C.; Levin, H.S.; Eisenberg, H.M.; Moore, B.D. Evoked potential indices of

selective hemispheric engagement in affective and phonetic tasks. Neuropsychologia 21:401-405; 1983.

29. Papanicolaou, A.C.; Schmidt, A.L.; Moore, B.D.; Eisenberg, H.M. Cerebral activation patterns

in an arithmetic and visuospatial processing task. Intern. J. Neurosci. 20:283-288; 1983. 30. Bracken, M.B.; Collins, W.F.; Freeman, D.F.; Shepard, M.F.; Ransohoff, J.; Hunt, W.E.; Perot,

P.L.; Grossman, R.G.; Green, B.A.; Eisenberg, H.M.; et al. Efficacy of methylprednisolone in acute spinal cord injury: A multicenter randomized trial. JAMA 251(1):45-68; 1984.

31. Loring, D.W.; Levin, H.S.; Papanicolaou, A.C.; Larrabee, G.J.; Eisenberg, H.M. Auditory

evoked potentials in senescent forgetfulness. Intern. J. Neurosci. 23:133-141; 1984. 32. Papanicolaou, A.C.; Levin, H.S.; Eisenberg, H.M. Evoked potential correlates of recovery from

aphasia after focal left hemisphere injury in adults. Neurosurgery 14:412-415; 1984. 33. Papanicolaou, A.C.; Levin, H.S.; Eisenberg, H.M.; Moore, B.D.; Goethe, K.E.; High, W.M.

Evoked potential correlates of post-traumatic amnesia after closed head injury. Neurosurgery 14:676-678; 1984.

CURRICULUM VITAE 14 Howard M. Eisenberg, M.D. 34. Papanicolaou, A.C.; Loring, D.W.; Eisenberg, H.M. Age-related differences in recovery cycle of

auditory evoked potentials. Neurobiol. Aging 5:291-295; 1984. 35. Bracken, M.B.; Shepard, M.J.; Hellenbrand, K.G.; Collins, W.F.; Leo, L.S.; Freeman, D.G.;

Wagner, F.W.; Flamm, E.; Eisenberg, H.M.; et al. Methylprednisolone and neurologic function one year after injury: Results of the National Acute Spinal Cord Injury Study. J. Neurosurg. 63:704-713; 1985.

36. Hutchison, H.T.; Eisenberg, H.M.; Haber, B. High-affinity transport of glutamate in rat brain

microvessels. Exp. Neurol. 87:260-269; 1985. 37. Levin, H.S.; Handel, S.F.; Goldman, A.M.; Eisenberg, H.M.; Guinto, Jr., F.C. Magnetic

resonance imaging after "diffuse" nonmissile head injury: A neurobehavioral study. Arch. Neurol. 42:963-968; 1985.

38. Levin, H.S.; High, W.M.; Eisenberg, H.M. Impairment of olfactory recognition after closed head

injury. Brain 108:579-591; 1985. 39. Levin, H.S.; High, W.M.; Meyers, C.A.; Von Laufen, A.; Hayden, M.E.; Eisenberg, H.M.

Impairment of remote memory after closed head injury. J. Neurol. Neurosurg. Psychiat. 48:556-563; 1985.

40. Papanicolaou, A.C.; Loring, D.W.; Eisenberg, H.M. Evoked potential attenuation in the two-tone

paradigm. Intern. J. Psychophysiol. 3:23-28; 1985. 41. Papanicolaou, A.C.; Loring, D.W.; Eisenberg, H.M. Probe-evoked potential correlates of

hemispheric asymmetries during a speech shadowing task. Intern. J. Neurosci. 28:83-89; 1985. 42. Papanicolaou, A.C.; Loring, D.W.; Eisenberg, H.M. Stimulus offset P3 and temporal resolution

of uncertainty. Intern. J. Psychophysiol. 3:29-31; 1985. 43. Papanicolaou, A.C.; Loring, D.W.; Eisenberg, H.M. Temporal pattern effects on auditory evoked

potentials. Intern J. Neurosci. 26:53-57; 1985. 44. Papanicolaou, A.C.; Loring, D.W.; Raz, N.; Eisenberg, H.M. Relationship between stimulus

intensity and the P-300. Psychophysiol. 22:326-329; 1985. 45. Weiner, R.L.; Eisenberg, H.M. Radiographic evaluation of head injury: Key concepts. Trauma

Quarterly 2:26-39; 1985. 46. Deutsch, G.; Papanicolaou, A.C.; Eisenberg, H.M.; Loring, D.W.; Levin, H.S. CBF gradient

changes elicited by visual stimulation and visual memory tasks. Neuropsychologia 24:283-287; 1986.

CURRICULUM VITAE 15 Howard M. Eisenberg, M.D. 47. Levin, H.S.; Peters, B.H.; Kalisky, Z.; High, W.M., Jr.; Von Laufen, A.; Eisenberg, H.M.;

Morrison, D.P.; Gary, Jr., H.E. Effects of oral physostigmine and lecithin on memory and attention in closed head injured patients. Central Nervous System Trauma 3(4):333-342; 1986.

48. Loring, D.W.; Papanicolaou, A.C.; Meador, K.J.; Eisenberg, H.M. Second prior stimulus interval

effects on auditory evoked potentials. Intern. J. Psychophysiol. 4:197-201; 1986. 49. Nauta, H.J.W.; Briner, R.P.; Eisenberg, H.M. CT guided stereotactic brain biopsy in the pediatric

patient. Pediatr. Neurosci. 12:63-67; 1986. 50. Papanicolaou, A.C.; Loring, D.W.; Deutsch, G.; Eisenberg, H.M. Task-related EEG

asymmetries: A comparison of alpha blocking and beta enhancement. Intern. J. Neurosci. 30:81-85; 1986.

51. Papanicolaou, A.C.; Loring, D.W.; Eisenberg, H.M.; Raz, N.; Contreras, F.L. Auditory brain

stem evoked responses in comatose head injured patients. Neurosurgery 18:173-175; 1986. 52. Papanicolaou, A.C.; Raz, N.; Loring, D.W.; Eisenberg, H.M. Brainstem evoked response

suppression during speech production. Brain Lang. 27:50-55; 1986. 53. Deutsch, G.; Eisenberg, H.M. Frontal blood flow changes in recovery from coma. J. CBF

Metabol. 7:29-34; 1987. 54. Deutsch, G.; Papanicolaou, A.C.; Bourbon, T.; Eisenberg, H.M. Cerebral blood flow evidence of

right frontal activation in attention demanding tasks. Int. J. Neurosci. 36:23-28; 1987. 55. Ewing-Cobbs, L.; Levin, H.S.; Eisenberg, H.M.; Fletcher, J.M. Language functions following

closed head injury in children and adolescents. J. Clin. Exp. Neuropsychol. 9:575-592; 1987. 56. Kadekaro, M.; Vance, W.H.; Terrell, M.L.; Gary, Jr., H.E.; Eisenberg, H.M.; Sokoloff, L. Effects

of antidromic stimulation of the ventral root on glucose utilization in the ventral horn of the spinal cord in the rat. Proc. Natl. Acad. Sci. 84:5492-5495; 1987.

57. Levin, H.S.; Amparo, E.; Eisenberg, H.M.; Williams, D.H.; High, Jr., W.M.; McArdle, C.B.;

Weiner, R.L. Magnetic resonance imaging and computed tomography in relation to the neurobehavioral sequelae of mild and moderate head injuries. J. Neurosurg. 66:706-713; 1987.

58. Levin, H.S.; Goldstein, F.C.; Ghostine, S.Y.; Weiner, R.L.; Crofford, M.J.; Eisenberg, H.M.

Hemispheric disconnection syndrome persisting after anterior cerebral artery aneurysm rupture. Neurosurgery 21(6):831-838; 1987.

59. Levin, H.S.; High, Jr., W.M.; Goethe, K.E.; Sisson, R.A.; Overall, J.E.; Rhoades, H.M.;

Eisenberg, H.M.; Kalisky, Z.; Gary, Jr., H.E. The neurobehavioral rating scale: Assessment of the behavioral sequelae of head injury by the clinician. J. Neurol. Neurosurg. Psychiat. 50:183-193; 1987.

CURRICULUM VITAE 16 Howard M. Eisenberg, M.D. 60. Levin, H.S.; Lippold, S.C.; Goldman, A.; Handel, S.; High, Jr., W.M.; Eisenberg, H.M.; Zelitt,

D. Neurobehavioral functioning and magnetic resonance imaging in young boxers. J. Neurosurg. 67:657-667; 1987.

61. Levin, H.S.; Mattis, S.; Ruff, R.M.; Eisenberg, H.M.; Marshall, L.F.; Tabaddor, K.; High, Jr.,

W.M.; Frankowski, R.F. Neurobehavioral outcome of minor head injury: A three center study. J. Neurosurg. 66:234-243; 1987.

62. Marshall, L.F.; Knowlton, S.; Garfin, S.R.; Klauber, M.R.; Eisenberg, H.M.; Kopaniky, D.;

Miner, M.E.; Tabaddor, K.; Clifton, G.L. Deterioration following spinal cord injury: A multicenter study. J. Neurosurg. 66:400-404; 1987.

63. Papanicolaou, A.C.; Deutsch, G.; Bourbon, W.T.; Will, K.W.; Loring, D.W.; Eisenberg, H.M.

Convergent evoked potential and cerebral blood flow evidence of task-specific hemispheric differences. Electroencephalogr. Clin. Neurophysiol. 66:515-520; 1987.

64. Papanicolaou, A.C.; Moore, Bartlett D.; Levin, Harvey S.; Eisenberg, H.M. Evoked potential

correlates of right hemisphere involvement in language recovery following stroke. Arch. Neurol. 44:521-524; 1987.

65. Cohen, S.; Kadekaro, M.; Terrell, M.L.; Gary, Jr., H.E.; Eisenberg, H.M. Effects of apamin on

local rates of glucose utilization in the brain and in the spinal cord. Neurosci. Lett. 91:253-258; 1988.

66. Contreras, F.C.; Kadekaro, M.; Eisenberg, H.M. The effect of hyperbaric oxygen treatment on

glucose utilization in a freeze traumatized rat brain. J. Neurosurg. 68:137-141; 1988. 67. Deutsch, G.; Bourbon, W.T.; Papanicolaou, A.C.; Eisenberg, H.M. Visuospatial tasks compared

via activation of regional cerebral blood flow. Neuropsychologia 26:445-452; 1988. 68. Eisenberg, H.M.; Frankowski, R.F.; Contant, C.F.; Marshall, L.F.; Walker, M.D.;

Comprehensive Central Nervous System Trauma Centers. High dose barbiturate control of elevated intracranial pressure in patients with severe head injury. J. Neurosurg. 69:15-23; 1988.

69. Levin, H.S.; Amparo, E.; Eisenberg, H.M.; Williams, D.H.; High, Jr., W.M. Magnetic resonance

imaging in relation to neuropsychological effects of mild and moderate head injury. Functional Neurology 3(Suppl. 2):117-126; 1988.

70. Levin, H.S.; Eisenberg, H.M. Postconcussional syndrome. Neurotrauma Medical Report

2(4):1-3; 1988. 71. Levin, H.S.; Goldstein, F.C.; High, Jr., W.M.; Eisenberg, H.M. Disproportionately severe

memory deficit in relation to normal intellectual functioning after closed head injury. J. Neurol. Neurosurg. Psychiatry 51:1294-1301; 1988.

CURRICULUM VITAE 17 Howard M. Eisenberg, M.D. 72. Levin, H.S.; High, Jr., W.M.; Eisenberg, H.M. Learning and forgetting during posttraumatic

amnesia in head injured patients. J. Neurol. Neurosurg. Psychiatry 51:14-20; 1988. 73. Levin, H.S.; High, Jr., W.M.; Ewing-Cobbs, L.; Fletcher, J.M.; Eisenberg, H.M.; Miner, M.E.;

Goldstein, F.C. Memory functioning during the first year after closed head injury in children and adolescents. Neurosurgery 22:1043-1052; 1988.

74. Levin, H.S.; Williams, D.; Crofford, M.J.; High, Jr., W.M.; Eisenberg, H.M.; Amparo, E.G.;

Guinto, Jr., F.C.; Kalisky, Z.; Handel, S.F.; Goldman, A.M. Relationship of depth of brain lesions to consciousness and outcome after closed head injury. J. Neurosurg. 69:861-866; 1988.

75. Moore, B.D.; Kadekaro, M.; Gary, Jr., H.E.; Eisenberg, H.M. Electrophysiological evidence of

the neurotoxic effects of apamin on auditory function in the rat. Neurosci. Lett. 91:247-252; 1988.

76. Papanicolaou, A.C.; Moore, B.D.; Deutsch, G.; Levin, H.S.; Eisenberg, H.M. Evidence for right

hemisphere involvement in recovery from aphasia. Arch. Neurol. 45:1025-1029; 1988. 77. Papanicolaou, A.C.; Wilson, G.F.; Busch, C.; DeRego, P.; Orr, C.; Davis, I.; Eisenberg, H.M.

Hemispheric asymmetries in phonetic processing assessed with probe evoked magnetic fields. Int. J. Neurosci. 39:275-281; 1988.

78. Aldrich, E.F.; Eisenberg, H.M. Intensive care in neurological diseases. Current Opinion in

Neurology and Neurosurgery 2:9-14; 1989. 79. Bradley, R.H.; Kent, T.A.; Eisenberg, H.M.; Quast, M.E.; Ward, G.A.; Campbell, G.A.; Hillman,

G. Middle cerebral artery occlusion in the rat studied by magnetic resonance imaging using a superparamagnetic contrast agent, AMI-25. Stroke 20:1032-1036; 1989.

80. Kadekaro, M.; Creel, M.; Terrell, M.L.; Lekan, H.; Gary, H.E., Jr.; Eisenberg, H.M. Effects of

sinoaortic denervation on glucose utilization in the subfornical organ and pituitary neural lobe during administration of angiotensin II. Peptides 10:103-108; 1989.

81. Kadekaro, M.; Cohen, S.; Terrell, M.L.; Lekan, H.; Gary, H., Jr.; Eisenberg, H.M. Independent

activation of subfornical organ and hypothalamo-neurohypophysial system during administration of angiotensin II. Peptides 10:423-429; 1989.

82. Kent, T.A.; Quast, M.J.; Kaplan, B.J.; Najafi, A.; Amparo, E.G.; Gevedon, R.M.; Salinas, F.;

Suttle, A.D.; DiPette, D.J.; Eisenberg, H.M. Cerebral blood volume in a rat model of ischemia by MR at 4.7 T. Am. J. Neurol. Res. 10:335-338; 1989.

83. Klauber, M.R.; Marshall, L.F.; Luerssen, T.G.; Frankowski, R.; Tabaddor, K.; Eisenberg, H.M.

Determinants of head injury mortality: Importance of the low risk patient. Neurosurgery 24:31-36; 1989.

CURRICULUM VITAE 18 Howard M. Eisenberg, M.D. 84. Levin, H.S.; Amparo, E.G.; Eisenberg, H.M.; Miner, M.E.; High, W.M. Jr.; Ewing-Cobbs, L.;

Fletcher, J.M.; Guinto, F.C. Jr. Magnetic resonance imaging after closed head injury in children. Neurosurgery 24:223-227; 1989.

85. Levin, H.S.; Gary, Jr., H.E.; Eisenberg, H.M.; NIH Traumatic Coma Data Bank Research Group.

Duration of impaired consciousness in relation to lateralization of intracerebral lesion after severe head injury. Lancet 1:1001-1003; 1989.

86. Levin, H.S.; High, W.M. Jr.; Williams, D.; Eisenberg, H.M.; Amparo, E.G.; Guinto, F.C. Jr.;

Ewert, J. Dichotic listening and manual performance in relation to magnetic resonance imaging after closed head injury. J. Neurol. Neurosurg. Psychiatry 52:1162-1169; 1989.

87. Aldrich, E.F.; Eisenberg, H.M. Pitfalls in the acute emergency evaluation of head injured

patients. Top. Emerg. Med. 11:52-63; 1990. 88. Aldrich, E.F.; Levin, H.S.; Eisenberg, H.M. Management and outcome of head injuries. Current

Opinion in Neurology and Neurosurgery 3:10-17; 1990. 89. Bracken, M.B; Shepard, M.J.; Collins, W.F.; Holford, T.R.; Young, W.; Baskin, D.S.; Eisenberg,

H.M.; Flamm, E.; Leo-Summers, L.; Maroon, J.; Marshall, L.F.; Perot, Jr., P.L.; Peipmeier, J.; Sonntag, V.K.H.; Wagner, F.C.; Wilberger, J.E.; Winn, H.R. A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury: Results of the second national acute spinal cord injury study. New Engl. J. Med. 322:1405-1411; 1990.

90. Fletcher, J.M.; Ewing-Cobbs, L.; Miner, M.E.; Levin, H.S.; Eisenberg, H.M. Behavioral changes

after closed head injury in children. J. Consult. Clin. Psychol. 58:93-98; 1990. 91. Kadekaro, M.; Nermo-Lindquist, E.; Terrell, M.L.; Kelly, S.M.; Freeman, S.; Gross, P.M.;

Eisenberg, H.M. Desmopressin, but not vasopressin, decreases activity of the hypothalamo-neurohypophysial system in Brattleboro rats. Regulatory Peptides 28:153-159; 1990.

92. Kent, T.A.; Quast, M.J.; Kaplan, B.J.; Lifsey, R.S.; Eisenberg, H.M. Assessment of a

superparamagnetic iron oxide (AMI-25) as a brain contrast agent. Magn. Reson. Med. 13:434-443; 1990.

93. Papanicolaou, A.C.; Baumann, S.; Rogers, R.; Saydjari, C.; Amparo, E.G., and Eisenberg, H.M.

Localization of auditory response sources using MEG and MRI. Arch. Neurol. 47:33-37; 1990. 94. Rogers, R.L.; Papanicolaou, A.C.; Baumann, S.B.; Eisenberg, H.M.; Saydjari, C. Spatially

distributed cortical excitation patterns of auditory processing during contralateral and ipsilateral stimulation. J. Cogn. Neurosci. 2:44-50; 1990.

CURRICULUM VITAE 19 Howard M. Eisenberg, M.D. 95. Rogers, R.L.; Papanicolaou, A.C.; Baumann, S.B.; Saydjari, C.; Eisenberg, H.M. Neuromagnetic

evidence of a dynamic pattern generating the N100 auditory response. Electroencephalogr. Clin. Neurophysiol. 77:237-240; 1990.

96. Papanicolaou, A.C.; Rogers, R.L.; Baumann, S.B.; Saydjari, C.; Eisenberg, H.M. Source

localization of two evoked magnetic field components using two alternative procedures. Exp. Brain Res. 80:44-48; 1990.

97. Levin, H.S.; Williams, D.H.; Valastro, M.; Eisenberg, H.M.; Crofford, M.J.; Handel, S.F. Corpus

callosum atrophy following closed head injury: Detection with magnetic resonance imaging. J. Neurosurg. 73:77-81; 1990.

98. Ruff, R.M.; Marshall, L.F.; Klauber, M.R.; Blunt, B.A.; Grant, I.; Foulkes, M.A.; Eisenberg, H.;

Jane, J.; Marmarou, A. Alcohol abuse and neurological outcome of the severely head injured. J. Head Trauma Rehabil. 5:21-31; 1990.

99. Kadekaro, M.; Summy-Long, J.Y.; Terrell, M.L.; Lekan, H.; Gary, H.E., Jr.; Eisenberg, H.M.

Cerebral metabolic and hormonal activations during hemorrhage in sinoaortic-denervated rats. Am. J. Physiol. 259:R305-R312; 1990.

100. Williams, D.H.; Levin, H.S.; Eisenberg, H.M. Mild head injury classification. Neurosurgery

27:422-428; 1990. 101. Ewing-Cobbs, L.; Levin, H.S.; Fletcher, J.M.; Miner, M.E.; Eisenberg, H.M. The Children's

Orientation and Amnesia Test: Relationship of severity of acute head injury and recovery of memory to memory performance. Neurosurgery 27:683-691; 1990.

102. Levin, H.S.; Gary, Jr., H.E.; Eisenberg, H.M.; Ruff, R.M.; Barth, J.T.; Kreutzer, J.; High, Jr.,

W.M.; Portman, S.; Foulkes, M.A.; Jane, J.A.; Marmarou, A; Marshall, L.F. Neurobehavioral outcome one year after severe head injury: Experience of the Traumatic Coma Data Bank. J. Neurosurg. 73:699-709; 1990.

103. Eisenberg, H.M.; Gary, H.E. Jr.; Aldrich, E.F.; Saydjari, C.; Turner, B.; Foulkes, M.A.; Jane,

J.A.; Marmarou, A.; Marshall, L.F.; Young, H.F. Initial CT scan findings in 753 patients with severe head injury: A report from the NIH Traumatic Coma Data Bank. J. Neurosurg. 73:688-698; 1990.

104. Eisenberg, H.M.; Papanicolaou, A.C.; Baumann, S.B.; Rogers, R.L.; Brown, L.M.

Magnetoencephalographic localization of interictal spike sources: case report. J. Neurosurg. 74:660-664; 1991.

105. Levin, H.S.; Eisenberg, H.M.; Gary, Jr., H.E.; Marmarou, A.; Foulkes, M.A.; Jane, J.A.;

Marshall, L.F. Intracranial hypertension in relation to memory functioning during the first year after severe head injury. Neurosurgery 28(2):196-200; 1991.

CURRICULUM VITAE 20 Howard M. Eisenberg, M.D. 106. Levin, H.S.; Saydjari, C.; Eisenberg, H.M.; Foulkes, M.; Marshall, L.F.; Jane, J.A.; Marmarou,

A. Vegetative state after closed-head injury: A Traumatic Coma Data Bank report. Arch. Neurol. 48:580-585; 1991.

107. Baumann, S.B.; Rogers, R.L.; Guinto, F.C.; Saydjari, C.L.; Papanicolaou, A.C.; Eisenberg, H.M.

Gender differences in source location for the N100 auditory evoked magnetic field. Electroencephalogr. Clin. Neurophysiol. 80:53-59; 1991.

108. Rogers, R.L.; Baumann, S.B.; Papanicolaou, A.C.; Bourbon, T.W.; Alagarsamy, S.; Eisenberg,

H.M. Localization of the P3 sources using magnetoencephalography and magnetic resonance imaging. Electroencephalogr. Clin. Neurophysiol. 79:308-321; 1991.

109. Foulkes, M.A.; Eisenberg, H.M.; Jane, J.A.; Marmarou, A.; Marshall, L.F.; Traumatic Coma

Data Bank Research Group. The Traumatic Coma Data Bank: Design, methods and baseline characteristics. J. Neurosurg. (Suppl.) 75:S8-S13; 1991.

110. Marshall, L.F.; Marshall, S.B.; Clark, M.; Luerssen, T.; Eisenberg, H.M.; Foulkes, M.A.;

Marshall, L.F.; Jane, J.A. Impact of ICP instability and hypotension on outcome in patients with severe head trauma. J. Neurosurg. (Suppl.) 75:S59-S66; 1991.

111. Marmarou, A.; Anderson, R.L.; Ward, J.D.; Choi, S.C.; Young, H.F.; Eisenberg, H.M.; Foulkes,

M.A.; Marshall, L.F.; Jane, J.A. NINDS Traumatic Coma Data Bank (TCDB): Intracranial pressure monitoring methodology. J. Neurosurg. (Suppl.) 75:S21-S27; 1991.

112. Vollmer, D.G.; Torner, J.C.; Jane, J.A.; Sadovnic, B.; Charlebois, D.; Eisenberg, H.M.; Foulkes,

M.A.; Marmarou, A.; Marshall, L.F. Age and outcome following traumatic coma: Why do older patients fare worse? J. Neurosurg. (Suppl.) 75:S37-S49; 1991.

113. Ruff, R.M.; Young, D.; Levin, H.S.; Kreutzer, J.; Barth, J.; Gautille, T.; Marshall, L.F.;

Eisenberg, H.M.; Foulkes, M.A.; Jane, J.; Marmarou, A. Verbal learning deficits following severe head injury: Heterogeneity in recovery over one year. J. Neurosurg. (Suppl.) 75:S50-S58; 1991.

114. Marshall, L.F.; Gautille, T.; Klauber, M.R.; Eisenberg, H.M.; Jane, J.A.; Luerssen, T.;

Marmarou, A.; Foulkes, M.A.. Outcome of severe closed head injury. J. Neurosurg. (Suppl.) 75:S28-S36; 1991.

115. Marshall, L.F.; Marshall, S.B.; Klauber, M.R.; Clark, M.; Eisenberg, H.M.; Jane, J.A; Luerssen,

T.; Marmarou, A.; Foulkes, M.A. A new classification of head injury based on computerized tomography. J. Neurosurg. (Suppl.) 75:S14-S20; 1991.

116. Terrell, M.L.; Kadekaro, M.; Freeman, S.; Eisenberg, H.M. Effects of chemical stimulation of

the subfornical organ on metabolic activity of the hypothalamo-neurohypophysial system in rats. Neurosci. Letters. 134:122-126; 1991.

CURRICULUM VITAE 21 Howard M. Eisenberg, M.D. 117. Aldrich, E.F.; Eisenberg, H.M.; Saydjari, C.; Foulkes, M.A.; Jane, J.A.; Marshall, L.F.; Young,

H.; Marmarou, A. Predictors of mortality in severely head injured civilian gunshot wounds. A report from the National Institutes of Health Traumatic Coma Data Bank. Surg. Neurol. 38:418-423; 1992.

118. Aldrich, E.F.; Eisenberg, H.M.; Saydjari, C.; Luerssen, T.G.; Foulkes, M.A.; Jane, J.A.;

Marshall, L.F.; Marmarou, A.; Young, H. Diffuse brain swelling in severely head-injured children: a report from the NIH Traumatic Coma Data Bank. J. Neurosurg. 76:450-454; 1992. * Selected for publication in 1993 Mosby Yearbook. St. Louis: Mosby Yearbook, Inc.; 1993.

119. Bracken, M.B.; Shepard, M.J.; Collins, W.F.; Holford, T.R.; Baskin, D.S.; Eisenberg, H.M.;

Flamm, E.; Leo-Summers, L.; Maroon, J.C.; Marshall, L.F.; Perot, P.L.; Piepmeier, J.; Sonntag, V.K.H.; Wagner, F.C.; Wilberger, J.L.; Winn, H.R.; Young, W. Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. J. Neurosurg. 76:23-31; 1992.

120. Kadekaro, M.; Summy-Long, J.Y.; Freeman, S., Harris, J.S.; Terrell, M.L.; Eisenberg, H.M.

Cerebral metabolic responses and vasopressin and oxytocin secretions during progressive water deprivation in rats. Am. J. Physiol. 262:310-317; 1992.

121. Levin, H.S; Aldrich, E.F.; Saydjari, C.; Eisenberg, H.M.; Foulkes, M.A.; Bellefleur, M.; Jane,

J.A.; Marmarou, A.; Marshall, L.F.; Young, H. Severe head injury in children: Experience of the Traumatic Coma Data Bank. Neurosurgery 31:435-444; 1992.

122. Levin, H.S.; Goldstein, F.C.; Crofford, M.J.; Eisenberg, H.M.; Guinto, F.C., Jr. Infantile right

hemisphere injury: A case report with MRI and 13 year followup. Restorative Neurol. Neurosci. 4:271-277; 1992.

123. Levin, H.S.; Mendelsohn, D.; Bruce, D.; Harward, H.; Culhane, K.A.; Eisenberg, H.M.

Reversibility of cerebral atrophy after head injury in children. Neurosurgery 31(6):1117-1122; 1992.

124. Levin, H.S.; Williams, D.H.; Eisenberg, H.M.; High, Jr., W.M.; Guinto, Jr., F.C. Serial magnetic

resonance imaging and neurobehavioral findings after mild to moderate closed head injury. J. Neurol. Neurosurg. Psychiatry 55:255-262; 1992.

125. Mendelsohn, D.; Levin, H.S.; Bruce, D.; Lilly, M.A.; Harward, H.; Culhane, K.; Eisenberg,

H.M. Late MRI after head injury in children: Relationship to clinical features and outcome. Childs Nerv. Syst. 8:445-452; 1992.

126. Piek,J.; Chestnut, R.M.; Marshall, L.F.; vanBerkum-Clark, M.; Klauber, M.R.; Blunt, B.A.;

Eisenberg, H.M.; Jane, J.A.; Marmarou, A.; Foulkes, M.A. Extracranial complications of severe head injury. J. Neurosurg. 77(6):901-907; 1992.

CURRICULUM VITAE 22 Howard M. Eisenberg, M.D. 127. Rogers, R.L.; Papanicolaou, A.C., Baumann, S.B., Eisenberg, H.M. Late magnetic fields and

positive evoked potentials following infrequent and unpredictable omissions of visual stimuli. Electroencephalogr. Clin. Neurophysiol. 83(2):146-152; 1992.

128. Westlund, K.N.; Lu, Y.; Werrbach-Perez, K.; Hulsebosch, C.E.; Morgan, B.; Pizzo, D.P.;

Eisenberg, H.M.; Perez-Polo, J.R. Effects of nerve growth factor and acetyl-L-carnitine arginyl amide on the human neuronal line HCN-1A. Int. J. Devl. Neuroscience, Vol.10, No 5, pp. 361-373, 1992.

129. Clifton, G.L.; Kreutzer, J.S.; Choi, S.C.; Devany, C.W.; Eisenberg, H.M.; Foulkes, M.A.; Jane,

J.A.; Marmarou A.; Marshall, L.F. Relationship between Glasgow Outcome Scale and neuropsychological measures after brain injury. Neurosurg. 33(1):34-39, 1993.

130. Eisenberg, H.M.; Kadekaro, M.; Freeman, S.; Terrell, M.L. Metabolism in the globus pallidus

after fetal implants in rats with nigral lesions. J. Neurosurg. 78 (1):83-89; 1993. 131. Levin, H.S., Mattson, A.J.; Levander, M.; Lindquist, C.E.H.; Simard, J.M.; Guinto, F.C. Jr.;

Eisenberg, H.M. Effects of transcallosal surgery on interhemispheric transfer of information. Surg. Neurol. 40:65-74, 1993.

132. Ruff, R.M.; Marshall, L.F.; Crouch, J.; Klauber, M.R.; Levin, H.S.; Barth, J.; Kreutzer, J.; Blunt,

B.; Foulkes, M.; Eisenberg, H.M.; Jane, J.A.; Marmarou, A. Predictors of outcome following severe head trauma: follow-up data from the Traumatic Coma Data Bank. Brain Injury 7:101-111; 1993.

133. Simard, J.M.; Song, Y.; Tewari, K.; Dunn, S.; Werrbach-Perez, K.; Perez-Polo, J.R.; Eisenberg,

H.M. Ionic channel currents in cultured neurons from human cortex. J. Neurosci. Res. 34:170-178; 1993.

134. Levin, H.S.; Mendelsohn, D.; Lilly, M.A.; Fletcher, J.M.; Culhane, K.A.; Chapman, S.B.;

Harward, H.; Kusnerik, L.; Bruce, D.; Eisenberg, H.M. Tower of London performance in relation to magnetic resonance imaging following closed head injury in children. Neuropsychology 8(2):171-179; 1993.

135. Levin, H.S.; Culhane, K.A.; Mendelsohn, D.; Lilly, M.A.; Bruce, D.; Fletcher, J.M.; Chapman,

S.B.; Harward, H.; Eisenberg, H.M. Cognition in relation to MRI in head injured children and adolescents. Arch. Neurol. 50:897-905; 1993.

136. Chesnut, R.M.; Marshall, L.F.; Klauber, M.; Blunt, B.; Eisenberg, H.M.; Jane, J.A.; Marmarou,

A.; Foulkes, M.A. The role of secondary brain injury in determining outcome from severe head injury. J. Trauma 34(2): 216-22, 1993.

137. Rogers, R.L.; Basile L.F.; Papanicolaou, A.C.; Eisenberg, H.M. Magnetoencephalography

reveals two distinct sources associated with late positive evoked potentials during visual odd-ball task. Cerebral Cortex 3(2): 163-69, 1993.

CURRICULUM VITAE 23 Howard M. Eisenberg, M.D. 138. Rogers, R.L.; Basile, L.F.H.; Papanicolaou, A.C.; Bourbon, T.W.; Eisenberg, H.M. Visual

evoked magnetic fields reveal activity in the superior temporal sulcus. Electroencephalogr. Clin. Neurophysiol. 86(5) 344-7, 1993.

139. Dhib-Jalbut, S.; Hoffman, P.M.; Yamabe, T.; Sun, D.; Xia, J.; Eisenberg, H.; Bergey, G.;

Ruscetti, F.W. Extracellular human T-cell lmphotropic virus type I Tax-protein induces cytokine production in adult human microglial cells. Ann. Neurol.36(5): 787-90, 1994.

140. Cantrell, D.T.; Levin, H.S.; Capruso, D.X.; Eisenberg, H.M. Reversible amnesia associated with

a left temporal hematoma in a case of right temporal complex partial seizures. Epilepsia 35(6): 1321-27, 1994.

141. Levin, H.S.; Culhane, K.A.; Fletcher, J.M.; Mendelsohn, D.B.; Lilly, M.A.; Harward, H.;

Chapman, S.B.; Bruce D.A.; Eisenberg, H.M. Dissociation between delayed alternation and memory after pediatric head injury: Relationship to MRI findings. J. Child Neurol. 9(1):81-89; 1994.

142. Goldstein, F.C.; Levin, H.S.; Presley, R.M.; Searcy, J.; Colohan, A.R.T.; Eisenberg, H.M.; Jann,

B.; Kusnerik-Bertolino, L. Neurobehavioral consequences of closed head injury in older adults. J. Neurol., Neurosurg., and Psychiatry 57:961-966, 1994.

143. Thompson, N.M.; Francis, D.J.; Stuebing, K.K.; Fletcher J.M.; Ewing-Cobbs, L.; Miner, M.E.;

Levin, H.S.; Eisenberg, H. Recovery of motor, visual-spatial, and somatosensory skills after traumatic brain injury in children and adolescents: a study of change. Neuropsychol. 8: 333-342, 1994.

144. Ingram, F.; Levin, H.S.; Guito, F.C.; Eisenberg, H.M. Case Report of a Massive Congenital Left

Hemisphere Lesion: Support for the Crowding Hypothesis? Developmental Neuropsychology 10(4): 443-453, 1994.

145. Berryhill, P.; Lilly, M.A.; Levin, H.S.; Hillman, G.R.; Mendelsohn, D.; Brunder, D.G.; Fletcher,

J.M.; Kufera, J.; Kent, T.A.; Yeakley, J.; Bruce, D.; Eisenberg, H.M. Frontal lobe changes after severe diffuse closed head injury in children: a volumetric study of magnetic resonance imaging. Neurosurg. 37: 392-400, 1995.

146. Westlund, K.N.; Lu, Y.; Kadekaro, M.; Harmann, P.; Terrell, M.L.; Pizzo D.P.; Hulsebosch

C.E.; Eisenberg H.M.; Perez-Polo, J.R. NGF-producing transfected 3T3 cells: Behavioral and histological assessment of transplants in nigral lesioned rats. J. Neuroscience Res. 41(3): 367-73, 1995.

147. Morikawa, M., Numaguchi, Y., Rigamonti, D., Kuroiwa, T., Rothman, M., Zoarski, G., Simard,

J., Eisenberg, H., Amin, P. Radiosurgery for cerebral arteriovenous malformations: Assessment of early phase MR imaging and significance of Gd-DTPA enhancement. Int. J. Rad. Biol. Onc. Phys. 34: 663-675, 1996.

CURRICULUM VITAE 24 Howard M. Eisenberg, M.D. 148. Levin, H.S., Fletcher, J.M., Kufera, J.A., Harward, H., Lilly, M.A., Mendelsohn, D., Bruce, D.,

Eisenberg, H.M. Dimensions of cognition measured by the Tower of London and other cognitive tasks in head-injured children and adolescents. Dev. Neuropsych. 12(1): 17-34, 1996.

149. Dhib-Jalbut, S., Gogate, N., Jiang, H., Eisenberg, H., Bergey, G. Human microglia activate

lymphoproliferative responses to recall viral antigens. J. Neuroimmunology 65: 67-73, 1996. 150. Holloway, K.L., Barnes, T., Choi S., Bullock, R., Eisenberg, H.M., Marshall, L.F., Jane, J.A.,

Ward J.D., Marmarou, A. Ventriculostomy Infections: The effect of monitoring duration and catheter exchange in 584 patients. J. Neurosurg. 85: 419-424, 1996.

151. Albuquerque, E.X., Alkondon, M., Pereira, E.F.R., Castro, N.G., Schrattenholz, A., Barbosa,

C.T.F., Bonfante-Cabarcas, R., Aracava, Y., Eisenberg, H., and Maelicke, A. Properties of neuronal nicotinic acetylcholine receptors: Pharmacological characterization and modulation of synaptic function. J. Pharmacol. Exp. Ther. 280: 1117-1136, 1997. (Otto Krayer Award Lecture in Pharmacology and Experimental Therapeutics).

152. Franaszcuk, P.J., Bergey, G.K., Durka, P.J., Eisenberg, H.M. Time-frequency analysis using the

matching pursuit algorithm applied to seizures originating from the mesial temporal lobe. Electroenceph. clin. Neurophysiol. 106: 513-521, 1998.

153. Folse, J.R., Andriole, D.P., Debas, H.T., Denton, J.R., Eisenberg, H.M., et. al. Prerequisite

objectives for graduate surgical education: A study of the Graduate Medical Education Committee American College of Surgeons. J. Am. Coll. Surg. 186: 50-62, 1998.

154. Alkondon, M., Pereira, E.F.R., Eisenberg, H.M., and Albuquerque, E.X. Choline and selective

antagonists identify two subtypes of nicotinic acetylcholine receptors that modulate GABA release from CA1 interneurons in rat hippocampal slices. J. Neurosci. 19:2693-2705, 1999.

155. Wevers, A., Monteggia, L., Nowacki, S., Bloch, W., Schutz, U., Lindstrom, J., Pereira, E.F.R.,

Eisenberg, H.M., et al. Expression of nicotinic acetylcholine receptor subunits in the cerebral cortex in Alzheimer’s disease – Histotopographical correlation with amyloid plaques and hyperphosphorylated tau-protein. Eur. J. Neurosci. 11: 2551-2555, 1999.

156. Albuquerque, E.X., Pereira, E.F.R., Mike, A., Eisenberg, H.M., Maelicke, A., and Alkondon, M.

Neuronal nicotinic receptors in synaptic functions in humans and rats: Physiological and clinical relevance. Behav. Brain Res. 113:131-141, 2000.

157. Alkondon, M., Pereira, E.F.R., Eisenberg, H.M., Albuquerque, E.X. Nicotinic receptor

activation in human cerebral cortical interneurons: A mechanism for inhibition and disinhibition of neuronal networks. J. Neurosci. 20: 66-75, 2000.

CURRICULUM VITAE 25 Howard M. Eisenberg, M.D. 158. Sansur, C.A., Chin, L.S., Ames, J.W., Banegura, A.T., Aggarwal, S., Ballesteros, M., Amin, P.,

Simard, J.M., Eisenberg, H.M. Gamma Knife Radiosurgery for the treatment of brain metastases. Stereotact. Funct. Neurosurg. 74: 37-51, 2000.

159. Albuquerque, E.X., Pereira, E., Mike, A., Eisenberg, H.M., Maelicke, A., Alkondon, M.

Neuronal nicotinic receptors in synaptic functions in humans and rats: physiological and clinical relevance. Behavioral Brain Research 113: 131-141, 2000.

160. Bergey, G.K., Small, S.L., Eisenberg, H.M. Functional MRI localization of motor function.

Arch Neurol. 57(5):749, 2000. 161. Alkondon, M., Pereira, E.F.R., Eisenberg, H.M., Albuquerque, E.X. Choline and selective

antagonists identify two subtypes of nicotinic acetylcholine receptors that modulate GABA release from CA1 interneurons in rat hippocampal slices. J. Neurosci.20: 66-75, 2000.

162. Sansur, C.A., Chin, L.S., Ames, J.W., Banegura, A.T., Aggarwal, S., Ballesteros, M., Amin, P.,

Simard, J.M., Eisenberg, H.M. Gamma Knife radiosurgery for treatment of brain metastases. Stereotact Funct Neurosurg 74:37-51, 2000.

163. Albuquerque, E.X., Pereira, E., Mike, A., Eisenberg, H.M., Maelicke, A., Alkondon, M.,

Neuronal nicotinic receptors in synaptic functions in humans and rats: physiological and clinical relevance. Behavioral Brain Research 113:131-141, 2000.

164. Bergey, G.K., Small, S.L., Eisenberg, H.M. Functional MRI localization of motor function.

Arch Neurol. 57(5): 749, 2000. 165. Alkondon, M., Pereira, E.F.R., Eisenberg, H.M., Albuquerque, E.X. Choline and selective

antagonists identify two subtypes of nicotinic acetylcholine receptors that modulate GABA release from CA1 interneurons in rat hippocampal slices. J. Neurosci. 20:66-75, 2000

166. Sabsurm C.A., Chin, L.S., Ames, J.W., Banegura, A.T., Aggarwal, S., Ballesteros, M., Amin, P.,

Simrad, J.M., Eisenberg, H.M. Gamma Knife radiosurgery for treatment of brain metastases. Stereotact Funct Neurosurg 74:37-51, 2000.

167. Giorgi, C., Sala, R., Riva, D., Cossu, A., and Eisenberg, H. Robotics in child neurosurgery. Child's nervous system : ChNS : Official Journal of the International Society for Pediatric Neurosurgery16(10-11):832-4, 2000.

168. Aarabi, B., Alden, T.D., Chestnut, R.M., Downs, J.H., Ecklund, J.M., Eisenberg, H.M., Farace,

E., Florin, R.E., Jane Jr., J.A., Krieger, M.D., Maas, A.I.R., Narayan, R.K., Potapov, A.A., Salazar, A.M., Shaffrey, M.E., Walters, B.C. Management and Prognosis of Penetrating Brain Injury. J Trauma 51(2) Supplement/August:S1-S86, 2001.

CURRICULUM VITAE 26 Howard M. Eisenberg, M.D. 169. Petit, J.H., Hudes, R.S., Chen, T.S., Eisenberg, H.M., Simard, J.M., Chin, L.S. Reduced dose

radiosurgery for vestibular schwannomas. Neurosurgery 49:1299-1307, 2001. 170. Santos, M.D., Alkondon, M., Pereira, E.F.R., Aracava, Y., Eisenberg, H.M., Maelicke, A., and

Albuquerque, E.X. The nicotinic allosteric potentiating ligand galantamine facilitates synaptic transmission in the mammalian central nervous system. Mol Pharmacol. 61:1222-1234, 2002.

171. Aarabi, B., Hesdorffer, D.C., Ahn, E., Aresco, C., Scalea, T.M., and Eisenberg, H.M. Outcome

following decompressive craniectomy for malignant swelling following severe head injury. J Neurosurg. 104:467-468, 2006.

172. Aarabi, B., Hesdorffer, D.C., Simrad, J.M., Ahn, E.S., Aresco, C., Eisenberg, H.M., McCunn,

M., Scalea, T.: Comparative study of decompressive crainectomy after mass lesion evacuation in severe head injury. Neurosurgery 64(5): 927-39, discussion 939-40, 2009.

173. Zafonte, R., Friedewald, W.T., Lee, S.M., Levine, B., Diaz-Arrastia, R., Ansel, B., Eisenberg,

H., Timmons, S.D., Temkin, N., Novack, T., Ricker, J., Merchant, R., and Jallo, J. The citicoline brain injury treatment (COBRIT) trial: design and methods. Journal of Neurotrauma 26(12): 2209-16, 2009.

174. Alkondon, M., Pereira,E.F.R., Eisenberg,H.M., Kajii,Y., Schwarcz, R., and Albuquerque, E.X..

Age dependency of inhibition of α7 nicotinic receptors and tonically active NMDA receptors by endogenously produced kynurenic acid in the brain. J. Pharmacol. & Exp. Ther., 337(3):572-82, 2011.

175. Timmons, S.D., Ullman, J.S., and Eisenberg, H.M. Craniectomy in diffuse traumatic brain

injury. New England Journal of Medicine, 365(4):373; author reply 376, 2011. BOOKS 1. Eisenberg, H.M.; Suddith, R.L. (Eds.) The Cerebral Microvasculature: Investigation of the

Blood-Brain Barrier. New York: Plenum Publishing Corp.; 1980. 2. Levin, H.S.; Grafman, J.; Eisenberg, H.M. (Eds.) Neurobehavioral Recovery from Head Injury.

New York: Oxford University Press; 1988. 3. Levin, H.S.; Eisenberg, H.M.; Benton, A.L. (Eds.) Mild Head Injury. New York: Oxford

University Press; 1989. 4. Eisenberg, H.M.; Aldrich, E.F. (Eds.) Neurosurgery Clinics of North America: Management of

Head Injury. Philadelphia, Pennsylvania: W.B. Saunders; 1991. 5. Levin, H.S.; Eisenberg, H.M.; Benton, A.L. (Eds.) Frontal Lobe Function and Dysfunction. New

York: Oxford University Press; 1991.

CURRICULUM VITAE 27 Howard M. Eisenberg, M.D. 6. Levin, H.S.; Benton, A.L.; Muizelaar, J.P.; Eisenberg, H.M. (Eds.) Catastrophic Brain Injury.

New York: Oxford University Press; 1995. CHAPTERS 1. Grossman, R.G.; Lindquist, C.; Feinstein, R.; Eisenberg, H.M. Monitoring of the excitability of

the cerebral cortex in brain injury with the direct cortical response. In: Popp, A.J.; et al., Eds. Neural Trauma. New York: Raven Press: 237-243; 1979.

2. Eisenberg, H.M. Head injuries in children. In: Conn, H.F., Ed. Current Therapy. Philadelphia:

W.B. Saunders Company: 763-767; 1980. 3. Eisenberg, H.M.; Suddith, R.L.; Crawford, J.S. Transport of sodium and potassium across the

blood-brain barrier. In: Eisenberg, H.M.; Suddith, R.L., Eds. The Cerebral Microvasculature: Investigations of the Blood-Brain Barrier. New York: Plenum Publishing Corp.: 57-67; 1980.

4. Suddith, R.L.; Savage, K.E.; Eisenberg, H.M. Ultrastructural and histochemical studies of

cerebral capillary synapses. In: Eisenberg, H.M.; Suddith, R.L., Eds. The Cerebral Microvasculature: Investigations of the Blood-Brain Barrier. New York: Plenum Publishing Corp.: 139-145; 1980.

5. Eisenberg, H.M. Late complications of head injury. In: Pediatric Neurosurgery. New York:

Grune & Stratton: 321-331; 1982. 6. Eisenberg, H.M. New ways of looking at the blood-brain barrier. In: Visakay, C., Ed. Concepts

in Pediatric Neurosurgery II. New York: S. Karger Publishing Co., Inc.: 127-136; 1982. 7. Eisenberg, H.M. Supratentorial tumors: Astrocytoma, including intraventricular astrocytomas

associated with tuberous sclerosis. In: Pediatric Neurosurgery. New York: Grune & Stratton: 429-432; 1982.

8. Eisenberg, H.M.; Thompson, M.G.; Levin, H.S. Outcome in shunted hydrocephalic patients. In:

Cohen, M.M., ed. Monographs in Neural Sciences. Basel: S. Karger Publishing Co., Inc. (8):130-133; 1982.

9. Eisenberg, H.M.; Cayard, C.; Papanicolaou, A.C.; Weiner, R.L.; Franklin, D.; Jane, J.;

Grossman, R.; Tabaddor, K.; Becker, D.P.; Marshall, L.F.; Kumitz, S. The effects of three potentially preventable complications on outcome after severe head injury. In: Intracranial Pressure, V. Heidelberg: Springer-Verlag: 549-553; 1983.

10. Eisenberg, H.M.; Weiner, R.L. Syringomyelia. In: Rosenberg, R.N.; Grossman, R.G., Eds. The

Clinical Neurosciences, Vol. 2 Neurology/Neurosurgery. New York: Churchill Livingstone: 1399-1404; 1983.

CURRICULUM VITAE 28 Howard M. Eisenberg, M.D. 11. Levin, H.S.; Eisenberg, H.M.; Miner, M.E. Neuropsychologic findings in head injured children.

In: Shapiro, K., ed. Pediatric Head Trauma, New York: Futura Publishing Co., Inc.: 223-240; 1983.

12. Levin, H.S.; Eisenberg, H.M. The relative durations of coma and posttraumatic amnesia after

severe non-missile head injury: findings from the Pilot Phase of the Traumatic Coma Data Bank. In: Miner, M.; Wagner, K., Eds. Neural Trauma: Treatment, Monitoring and Rehabilitation Issues. Stoneham, Mass.: Butterworth Publishers; 1984.

13. Levin, H.S.; Papanicolaou, A.C.; Eisenberg, H.M. Observations on amnesia after nonmissile

head injury. In: Squire, L.; Butters, N., Eds. Neuropsychology of Memory. New York: The Guilford Press: 4247-257; 1984.

14. Eisenberg, H.M. Epidural Hematoma. In: Long, D.M., ed. Current Therapy in Neurological

Surgery. Philadelphia: B.C. Decker Inc.: 109-110; 1985. 15. Eisenberg, H.M.; Levin, H.S. Outcome after head injury: General considerations and

neurobehavioral recovery. Part I. General considerations. Part II. Neurobehavioral Recovery. In: Becker, D.; Povlishock, J., Eds. Central Nervous System Trauma Status Report. Bethesda: NINCDS: 271-280; 1985.

16. Eisenberg, H.M.; Levin, H.S.; Papanicolaou, A.C. Recovery of memory after head injury. In:

Dacey, ed. Trauma of the Central Nervous System. New York: Raven Press: 35-47; 1985. 17. Eisenberg, H.M.; Weiner, R.L. Benign Pituitary Cysts. In: Wilkins, R.H.; Rengachary, S.S., Eds.

Neurosurgery. New York: McGraw-Hill Book Company: 932-934; 1985. 18. Levin, H.S.; Kalisky, Z.; Handel, S.F.; Goldman, A.M.; Eisenberg, H.M.; Morrison, D.; Von

Laufen, A. Magnetic resonance imaging in relation to the sequelae and rehabilitation of diffuse closed head injury: Preliminary findings. In: Joynt, R.J., ed. Seminars in Neurology, Vol. 3. New York: Thieme-Stratton, Inc.: 221-232; 1985.

19. Weiner, R.L.; Eisenberg, H.M. Advances in Pediatric Neurosurgery. In: Pediatric Clinics of

North America, Vol. 32. Philadelphia: W.B. Saunders Company: 1125-1132; 1985. 20. Weiner, R.L.; Eisenberg, H.M. Head injuries in children. In: Rakel, R.E., Ed. Conn's Current

Therapy. Philadelphia: W.B. Saunders Company: 770-774; 1986. 21. Eisenberg, H.M.; Weiner, R.L. Input variables: How information from the acute injury can be

used to characterize groups of patients for studies of outcome. In: Levin, H.S.; Eisenberg, H.M.; Grafman, J., Eds. Neurobehavioral Recovery from Head Injury. New York: Oxford University Press; 1987.

22. Eisenberg, H.M.; Weiner, R.L.; Tabaddor, K. Emergency care: Initial evaluation. In: Cooper,

P.R., ed. Head Injuries, 2nd Edition. Baltimore: Williams & Wilkins: 20-33; 1987.

CURRICULUM VITAE 29 Howard M. Eisenberg, M.D. 23. Levin, H.S.; Eisenberg, H.M. Postconcussional syndrome. In: Johnson, R.T., ed. Current

Therapy in Neurologic Disease - 2. Philadelphia: B.C. Decker Inc.: 193-196; 1987. 24. Levin, H.S.; Gary, Jr., H.E.; High, Jr., W.M.; Mattis, S.; Ruff, R.M.; Eisenberg, H.M.; Marshall,

L.F.; Tabaddor, K. Minor head injury and the post-concussional syndrome: Methodological issues in outcome studies. In: Levin, H.S.; Eisenberg, H.M.; Grafman, J., Eds. Neurobehavioral Recovery from Head Injury. New York: Oxford University Press; 1987.

25. Eisenberg, H.M.; Levin, H.S. The devastated head injury patient. In: Clinical Neurosurgery, Vol.

34. Baltimore: Williams & Wilkins: Ch. 27:572-586; 1988. 26. Eisenberg, H.M. Mild/moderate brain injury - clinical diagnosis. In: Hoff, J.T., Anderson, T.,

Cole, T., Eds. Mild Head Injury, (Volume Three) of Contemporary Issues in Neurological Surgery. Boston: Blackwell Scientific Publications, Inc.: 95-105; 1989.

27. Eisenberg, H.M.; Briner, R.P. Late complications of head injury. In: R.L. McLaurin, L. Schut,

J.L. Venes, F. Epstein, Eds. Pediatric Neurosurgery, 2nd ed. Philadelphia: W.B. Saunders Company: 290-297; 1989.

28. Eisenberg, H.M.; Gary, H.E. Jr.; Turner, B.; Jane, J.A.; Marmarou, A.; Marshall, L.F.; Young,

H.; NIH TCDB Writing Group. CT scan findings in 683 patients with severe (Glasgow Coma Scale score < 8) closed head injury: A report from the NIH Traumatic Coma Data Bank. In: Intracranial Pressure VII, J.T. Hoff, A.L. Betz (Eds.), Springer-Verlag: 557-559; 1989.

29. Eisenberg, H.M.; Levin, H.S. Computed tomographic and magnetic resonance imaging in

mild/moderate head injury. In: H.S. Levin, H.M. Eisenberg, A.L. Benton, Eds. Mild Head Injury. New York: Oxford University Press: 133-141; 1989.

30. Fletcher, J.M.; Ewing-Cobbs, L.; Miner, M.E.; Levin, H.S.; Eisenberg, H.M. Adaptive behavior

in head injured children. In: M.E. Miner, K.A. Wagner, Eds. Neurotrauma: Treatment, Rehabilitation, and Related Issues, No. 3. Stoneham, Mass.: Butterworths: 103-114; 1989.

31. Marmarou, A.; Anderson, R.; Ward, J.D.; Eisenberg, H.M.; Jane, J.A.; Marshall, L.F.; Young,

H.F.; NIH TCDB Writing Group. The Traumatic Coma Data Bank: Monitoring of ICP. In: Intracranial Pressure VII, J.T. Hoff (Ed.), Springer-Verlag: 549-551; 1989.

32. Ruff, R.M.; Levin, H.S.; Mattis, S.; High, W.; Marshall, L.F.; Eisenberg, H.M.; Tabaddor, K.

Recovery of memory after mild head injury: A three center study. In: H.S. Levin, H.M. Eisenberg, A.L. Benton, Eds. Mild Head Injury. New York: Oxford University Press: 176-188; 1989.

33. Rogers, R.L.; Papanicolaou, A.C.; Baumann, S.; Saydjari, C.; Eisenberg, H.M. Nonstationary

dynamics of sequential magnetic dipole changes associated with N100 auditory evoked

CURRICULUM VITAE 30 Howard M. Eisenberg, M.D.

responses. In: S. Williamson, M. Hoke, G. Stroink, M. Kotani, Eds. Advances in Biomagnetism. New York: Plenum Press: 105-108; 1989.

34. Eisenberg, H.M. Head and spinal cord injury. In: Porter, R.J., Schoenberg, B.S., Eds. Controlled

Clinical Trials in Neurological Disease. Bethesda, Maryland: Kluwer Academic Publishers: 171-183; 1990.

35. Soloniuk, D.S.; Aldrich, E.F.; Eisenberg, H.M. Traumatic intracerebral hematomas. In: Pitts,

L.H., Wagner, F., Eds. The Craniospinal Trauma Volume. Trauma Management Series. New York: Thieme: 49-58; 1990.

36. Vollmer, D.G.; Eisenberg, H.M. Head injury in the elderly including subdural hematoma. In: W.

Hazzard, R. Andres, E. Bierman, J.P. Blass, Eds. Principles of Geriatric Medicine and Gerontology, 2nd ed. New York: McGraw-Hill Book Company: 990-998; 1990.

37. Aldrich, E.F.; Eisenberg, H.M. Management of acute cervical spinal cord injuries. Contemporary

Neurosurgery 12:1-8; 1990. 38. Levin, H.S.; Eisenberg, H.M. Neurobehavioral outcome. In: Eisenberg, H.M.; Aldrich, E.F., Eds.

Neurosurgery Clinics of North America. Philadelphia: W.B. Saunders Company.: Volume 2(2), pp. 457-472; 1991.

39. Eisenberg, H.M. Neurological surgery. In: What's new in surgery for 1991. Am. Coll. Surg. Bull.

76:27-29; 1991. 40. Eisenberg, H.M.; Weiner, R.L. Syringomyelia. In: Grossman, R.G.; Rosenberg, R.N. Eds.

Principles of Neurosurgery. New York: Raven Press; 1991. 41. Levin, H.S.; Goldstein, F.C.; Williams, D.H.; Eisenberg, H.M. The contribution of frontal lobe

lesions to the neurobehavioral outcome of closed head injury. In: Levin, H.S.; Benton, A.L.; Eisenberg, H.M., Eds. Frontal Lobe Function and the Effects of Injury. New York: Oxford University Press; 1991.

42. Levin, H.S.; Eisenberg, H.M. Neurobehavioral outcome. In: Eisenberg, H.M.; Aldrich, E.F., Eds.

Neurosurgery Clinics of North America. Philadelphia: W.B. Saunders; 1991. 43. Eisenberg, H.M. Treatment of neurotrauma patients - update '91. In: Gullo, A., Ed. Recent

Advances in Anaesthesia, Pain, Intensive Care, and Emergency. Trieste, Italy: Club A.P.I.C.E., pp. 285-293; 1991.

44. Luerssen, T.G.; Huang, J.C.; McLone, D.G.; Walker, M.L.; Hahn, Y.S.; Eisenberg, H.M.;

Humphreys, R.P.; Choux, M. Retinal hemorrhages, seizures, and intracranial hemorrhages-Relationships and outcomes in children suffering traumatic brain injury. In: Marlin, A.E., Ed. Concepts in Pediatric Neurosurgery, Vol. 11. Basel: S. Karger Publishing Company: 87-94; 1991.

CURRICULUM VITAE 31 Howard M. Eisenberg, M.D. 45. Aldrich, E.F.; Eisenberg, H.M. Acute subdural hematoma. In: Apuzzo, M.L.J., Ed. Brain

Surgery: Complication Avoidance and Management. New York: Churchill Livingstone: Chapter 34; 1992.

46. Levin, H.S.; Lilly, M.A.; Papanicolaou, A.C.; Eisenberg, H.M. Posttraumatic and retrograde

amnesia after closed head injury. In: Squire, L. & Butters, N., eds. Neuropsychology of Memory. New York: The Guilford Press: Chapter 26: pp. 290-308; 1992.

47. Luerssen, T.G., Eisenberg, H.M.; Levin, H.S. Late complications of pediatric head injury. In:

Cheek, W.R., Ed. Pediatric Neurosurgery, 3rd Edition. Orlando, W.B. Saunders Co: pp. 297-306, 1994.

48. Levin, H.S.; Eisenberg, H.M. Vegetative State after Head Injury: Findings from the Traumatic

Coma Data Bank. In: Levin, H.S., Benton, A.L., Muizelaar, J.P., & Eisenberg, H.M., eds. Catastrophic Brain Injury. New York: Oxford University Press: Chapter 3: pp. 35-50; 1995.

49. Levin, H.S.; Ewing-Cobbs, L.; Eisenberg, H.M. Neurobehavioral outcome of pediatric closed

head injury. In: Broman. S.H.; Michel, M.E., Eds. Traumatic head injury in children. New York: Oxford University Press: pp. 70-94, 1995.

50. Aldrich, E.F.; Eisenberg, H.M.: Diffuse brain injury. In: Tindall, G.T., Cooper, P.R., Barrow,

D.L., eds. The Practice of Neurosurgery. Baltimore: Williams and Wilkins: Chapter 198: pp. 1491-1501; 1996.

51. Aldrich, E.F.; Eisenberg, H.M.: Benign pituitary cysts. In: Wilkins, R.H., Rengarchary, S.S., eds.

Neurosurgery, 2nd ed. New York: McGraw-Hill: Chapter 134: pp. 1357-1366; 1996. 52. Aldrich, E.F.; Levin, H.S.; Eisenberg, H.M.: Mild Head Injury in Children. In: Youmans, J.R.,

ed. Neurological Surgery, 4th ed. Philadelphia: W.B. Saunders, Chapter 70: pp. 1719-1729; 1996.

53. Ullman, J.S.; Morgan, B.C.; Eisenberg, H.M.: Traumatic Subarachnoid Hemorrhage. In:

Bederson, J.B., ed. Subarachnoid Hemorrhage: Pathophysiology and Management. Park Ridge, Illinois: American Association of Neurological Surgeons: Chapter 14: pp. 225-237; 1997.

54. Aldrich EF, Eisenberg, HM: Prognostic Factors. In: Marion, D.W., ed. Traumatic Brain Injury,

New York, Thieme: Chapter 18: pp. 223-229, 1999. 55. Albuquerque, E.X.; Pereira, E.F.R.; Alkondon, M.; Eisenberg, H.; Maelicke, A. “Neuronal nicotinic

receptors and synaptic transmission in the central nervous system.” In Handbook of Experimental Pharmacology, F. Clementi, C. Gotti and D. Fornasari, eds. New York: Springer Verlag. Chapter 13 “Functional, Pharmacological and Modulatory Properties of the nAChRs”, pp. 337-358.

56. Aldrich EF, Chin LS, DiPatri AJ, Eisenberg HM: Neurosurgery. In: Townsend, C.M., ed.

CURRICULUM VITAE 32 Howard M. Eisenberg, M.D.

Sabiston Textbook of Surgery, 16th edition. Philadelphia, W.B. Saunders, Chapter 67, 2000 57. Chin, L.S.; Aldrich, E.F.; DiPatri, A.J.; Eisenberg, H.M.: Neurosurgery, in Townsend CM (ed),

Sabiston’s Textbook of Surgery, edition 17, WB Saunders (Philadelphia), 2004 58. Aarabi , B.; Eisenberg, H.; Murphy, K.; Morrison, C.; and Weinmann, M. Texbook of

Neurointensive Care. Traumatic Brain Injury: Management and Complications. Saunders 2004, pp771-794.

59. Aarabi, B.; O’Malley, B.; Martin, J.; and Eisenberg, H.: Cranial and Peripheral Nerve Surgery.

Surgical Management of CSF leaks. Thieme New York.

60. Aarabi, B.; Eisenberg, H.; Ahn, E.; Chiu, W.; Wintermark, M.: Minimally Invasive Procedures

in Traumatic Brain Injury. Peter Black and Mark Proctor (editors) Humana Press Inc., Totowa, NJ 2005, pp 399-420.

INSTRUCTIONAL MATERIAL Bresnan, M.F.; Nakano, K.K.; Snodgrass, S.R. With a contribution by Eisenberg, H.M. Pediatric Neurology, Medical Examination Review Book. New York: Medical Examination Publishing Company; 1976. Caruso, V.G.; Eisenberg, H.M.; Grossman, R.G. Transseptal surgery of the sphenoid sinus and sella turcia. In: A Self-Instructional Package from the Committee on Continuing Education in Otolaryngology. American Academy of Otolaryngology, a Division of the American Academy of Ophthalmology and Otolaryngology; 1977. Chin, LS; Singh, SK; Eisenberg, HM. Cell and molecular biology for neurosurgeons. Neurosurgical Focus 3: Article 1, 1997. PRESENTATIONS AND INVITED TALKS (since 1990) ″Application of evoked potential for cerebral localization in patients with brain injury or epilepsy″. Symposium on Neurology, Palermo, Italy; February 26-March 3, 1990. ″Computed tomographic findings and intracranial pressure in a large series of severely head injured patients″. Symposium on Neurology, Palmero, Italy; February 26-March 3, 1990. ″Head injury″. Post graduate course, Nagoya City University, Nagoya, Japan; April 2, 1990. ″ICP and CT findings in over 1,000 patients with severe head injury″. Honored Guest Lecturer, 13th Conference of the Japanese Society of Neurotraumatology, Tokyo, Japan; March 28, 1990. Moderator, American Association of Neurological Surgeons, Nashville, Tennessee; April 30, 1990.

CURRICULUM VITAE 33 Howard M. Eisenberg, M.D. Moderator, Meeting of the Society of Neurological Surgeons, Ann Arbor, Michigan; May 20-23, 1990. "Recent trends in brain protection". Lecturer and Discussion Designate, 10th Annual Meeting of the Japanese Congress of Neurological Surgeons, Tokyo, Japan; March 29-31, 1990. Visiting Professor, Tokai University, Tokai, Japan; April 3, 1990. "Recovery from severe and mild injury." Visiting Professor, Hong Kong Surgical Forum, Neurosurgery, Hong Kong; September 15-16, 1990. "Morbidity and mortality of severe head injury." Status Report on CNS Trauma: Clinical and Scientific Aspects, Seventh Conference on Neural Trauma. Charlottesville, Virginia; September 23-26, 1990. Visiting Professor, Department of Surgery, University of Hong Kong, Hong Kong Neurosurgical Forum; September, 1990. "Pediatric head injury." American Society of Pediatric Neurosurgeons Review Course. Orlando, Florida; January 17-19, 1991. "Magnetoencephalographic localization of interictal spike sources". Society of University Surgeons, Galveston, Texas; February, 1991. "New advances in the treatment of spinal cord injuries." Centennial Homecoming. The University of Texas Medical Branch, Galveston, Texas; March 17-23, 1991. "Management of the critically ill patient." Moderator, American Association of Neurological Surgeons. 59th annual meeting, New Orleans, Louisiana; April 20-25, 1991. "Neurological surgery. In: What's new in surgery for 1991". Am. Coll. Surg. Annual Meeting, San Francisco, California, 1991. Consultant to Upjohn Company. FDA hearing re. new drug U76004F; June 18, 1991. Chairperson, NIH Special Study Section, Trauma Centers P50; August 1-2, 1991. "P3 to missing tones." Eighth International Conference on Biomagnetism, Munster, F.R.G.; August 18-22, 1991. "Acute stage measurements". NIH - NINDS Conference on Outcome Measures in Head Injury Clinical Trials, Houston, Texas; October 7-9, 1991. Characterization of P3 sources using magnetoencephalography. Proceedings of the 4th International Evoked Potentials Symposium; 1991.

CURRICULUM VITAE 34 Howard M. Eisenberg, M.D. "Multi-center studies in severe head injury". Congress of Neurological Surgeons 41st Annual Meeting, Orlando, Florida; October 26-31, 1991. Recent Advances in Anaesthesia and Intensive Care. Moderator, Symposium on CNS Trauma, Trieste, Italy; November 23, 1991. Visiting Professor, Department of Neurosurgery, University of Messina, Italy; November 25, 1991. Visiting Professor, Department of Neurosurgery, University of Parma, Italy; November 26, 1991. Ad hoc reviewer, Center for Disease Control Grant Review Session, Atlanta, Georgia; January 12-14, 1992. "Craniocerebral missile injuries: Surgical decision making". Panelist, American Association of Neurological Surgeons 60th Annual Meeting, San Francisco, California; April 11-16, 1992. "ABNS Board Preparation". Panelist, American Association of Neurological Surgeons 60th Annual Meeting, San Francisco, California; April 11-16, 1992. "Magnetoencephalography reveals two distinct sources associated with the P300 during visual oddball paradigm". International Neuropsychological Society 14th European Conference, Durham, England; July 8-11, 1992. Chairperson, NIH Special Review Committee, Washington, D.C., August 6-7, 1992. Visiting Professor, Division of Neurosurgery, Oregon Health Sciences University, Portland, Oregon; September 10-12, 1992. "Transplantation of HCN-1A into rat brain". Society for Neuroscience 1992 Annual Meeting, Anaheim, California, October 25-30, 1992. "Ion channel currents in cultured HCN-1A neurons from human cortex". Society for Neuroscience 1992 Annual Meeting, Anaheim, California, October 25-30, 1992. "Outcome of severe head injury in children: A report from the Traumatic Coma Data Bank". NHIF 11th Annual National Symposium, Boston, Massachusetts; December 9-13, 1992. "Cognitive function in relation to MRI findings following closed head injury in children and adolescents". INS 21st Annual Meeting, Galveston, Texas; February 24-27, 1993. "Frontal lobe lesions in relation to outcome of pediatric head injury: Cognitive and MRI findings". AANS Annual Meeting, Boston, Massachusetts; April 24-29, 1993. "Long term recovery of memory following pediatric head injury". AANS Annual Meeting, Boston, Massachusetts; April 24-29, 1993.

CURRICULUM VITAE 35 Howard M. Eisenberg, M.D. "Contemporary management of pediatric head injury". AANS Annual Meeting (Breakfast Seminar), Boston, Massachusetts; April 28, 1993. "Management strategies for head injury: Factors in avoidance of early and long term adverse sequelae". AANS Annual Meeting (Breakfast Seminar), Boston, Massachusetts; April 28, 1993. "The Gamma Knife". The Eastern Surgical Society, Baltimore, Maryland; May, 1993. Moderator, Committee reports and subspecialization. Society of Neurosurgeons, San Diego, California; May, 1993. "Multicentered studies of central nervous system injury". National Advisory Neurologic Disorders and Stroke Council 127th Meeting, Bethesda, Maryland; June 1993. "Diagnosis and prognostic significance of traumatic subarachnoid haemorrhage". Glasgow, Scotland; July, 1993. "Preparation of a Grant". Course Director, Congress of Neurological Surgeons 43rd Annual Meeting, Vancouver, British Columbia; October 3, 1993. "Late Sequelae of Head Injury; Prevention and Management". Moderator, Congress of Neurological Surgeons 43rd Annual Meeting, Vancouver, British Columbia; October 5, 1993. Moderator, Free oral presentations. International Congress of Neurological Surgery, Acapulco, Mexico; October 20, 1993. "Surgical techniques for disraphysm". International Congress of Neurological Surgery, Acapulco, Mexico; October 21, 1993. "A neurosurgical perspective". National Institute of Neurological Disorders and Stroke, Bethesda, Maryland; November 18-19, 1993. "Surgical Management of Intractable Seizures". University of Maryland Medical Center's NeuroCare Outreach CME Program, Aberdeen, Maryland; May 25 and June 15, 1994 "The Coma Data Bank: Information and Lessons Learned in Acute Brain Injury Care". Advances in Acute Neurotrauma Care Conference, Hartford, Connecticut; June 9, 1994. "What's New With Brain Injury". Pennsylvania Neurosurgical Society, Philadelphia, Pennsylvania; September 9, 1994. Introducer, Advisory Council for Neurological Surgery Lecture (History of Surgery), American College of Surgeons Annual Clinical Congress, Chicago, Illinois; October 10, 1994.

CURRICULUM VITAE 36 Howard M. Eisenberg, M.D. "Perspective of a Program Director in Neurosurgery". Panel Discussion, American College of Surgeons Annual Clinical Congress, Chicago, Illinois; October 10, 1994. "Treatment of Neurotrauma". Invited Speaker, Ohio Society of Neurological Surgeons Annual Meeting, Mohican State Park, Ohio; November 19, 1994. Visiting Professor, Department of Neurosurgery, University of Pittsburgh, December 1-2, 1994. Invited Speaker, FDA/NIH Public Forum on Informed Consent in Clinical Research Conducted in Emergency Circumstances. Bethesda, Maryland; January 9-10, 1995. "DRG Assignment for Gamma Knife® Surgery". Representing Health Technology Associates, Inc. and Elekta, Washington, D.C.; February 28, 1995. "Current Management of Cerebral Trauma". The American Association of Neurological Surgeons 1995 Annual Meeting. Orlando Florida; April 22-27, 1995. "Management of Minor Closed Head Injury in Children and Adolescents". The American Association of Neurological Surgeons 1995 Annual Meeting. Orlando, Florida; April 22-27, 1995. "Stereotactic fusion of intraoperative image with 3D graphic reconstruction of cerebral anatomy." Joint International Congress on Minimally Invasive Techniques in Neurosurgery and Otolaryngology, Pittsburgh, Pennsylvania; June 18, 1995. "Outcome Analysis and Late Sequelae of Traumatic Brain Injury." Third International Neurotrauma Symposium, Toronto, Ontario, Canada; July 23, 1995. Introducer, History of Surgery lecturer Dr. Lennard Wilson, "The Evolution of Carotid Endarterectomy." 81st Annual Clinical Congress, American College of Surgeons, New Orleans, Louisiana; October 23, 1995. Moderator, "Critical Care Management of the Head Injured Patient." 45th Annual Meeting of The Congress of Neurological Surgeons, San Francisco, California; October 17, 1995. Session Chair, "Improving Therapy Following Severe Head Injury." J. Douglas Miller Symposium, La Jolla, California; February 12, 1996. Invited Speaker, “Applications of the Stereotactic Guided Microscope,” “Brain Protection and the Tirilazad Studies,” “Gamma Knife: Results with Metastatic Tumors.” Winter Congress on Minimally Invasive Techniques in Neurosurgery, Otolaryngology, and Radiology, Aspen, Colorado; March 17-21, 1996. Invited Participant, Young Surgical Investigators Conference, Surgical Research and Education Committee of the American College of Surgeons, Chantilly, Virginia; March 30-April 1, 1996.

CURRICULUM VITAE 37 Howard M. Eisenberg, M.D. Visiting Professor, Georgetown University School of Medicine, Department of Neurological Surgery, Washington, D.C.; April 3, 1996. Chair, Reverse Site Visit and Ad-Hoc Study Section, NIH-NINDS "International Unruptured Aneurysm Study." Competitive Renewal, Washington, D.C.; April 8-9, 1996. Moderator, "Current Management of Cerebral Trauma," "ABNS Board Preparation"; Discussant, "Outcome of Moderate and Severe Head Injury in Patients Treated with Tirilazad Mesylate"; Panelist, "Getting a Research Grant Funded." 64th Annual Meeting of the American Association of Neurological Surgeons, Minneapolis, MN; April 27 - May 2, 1996. Speaker, Program Director's Meeting, "Report from the Board." The 87th Meeting of the Society of Neurological Surgeons, Chicago, IL; May 12, 1996. Panelist, "Image Guided Surgery." Second International Skull Base Congress, Seventh Annual Meeting of the North American Skull Base Society, San Diego, CA; June 30, 1996. Invited Speaker, "Clinical Presentation of Spinal Cord Injury." NIH Workshop on Spinal Cord Injury: Emerging Concepts, Bethesda, MD; September 30, 1996. Panelist, "Assessment of Training Programs and Examinations." Conference on Neurosurgical Training: An International Meeting Under the Auspices of the European Association of Neurosurgical Societies, Munich, Germany; October 8, 1996. Moderator, "Plenary Session I: Managed Care." R. Adams Cowley 17th National Trauma Symposium, Baltimore, Maryland; November 7, 1996. Chair, "Conceptual Issues, Neuroscience, and Experimental Models." NIH Workshop on Neuroplasticity and Reorganization of Function after Brain Injury, Bethesda, Maryland; December 3, 1996. Moderator, "C-P Angle and Skull Base Tumors," March 27, 1997; Invited Speaker, "Acoustic Neuroma: Microsurgery or Gamma Knife," March 28, 1997; Invited Faculty, The 2nd Pan-Pacific Neurosurgery Congress: Craniovertebral Junction/Cervical Spine and C-P Angle Lesions, Honolulu, Oahu and Makena, Maui, Hawaii, March 23-29, 1997. Moderator, "ABNS Board Preparation." American Association of Neurological Surgeons, Denver, Colorado; April 16, 1997. Introducer, History of Surgery lecturer. 83rd Annual Clinical Congress, American College of Surgeons, Chicago, Illinois; October 13, 1997. Invited speaker, “Medical and Surgical Management of Epilepsy”, Shipley’s Choice, Millersville, Maryland; November 13, 1997.

CURRICULUM VITAE 38 Howard M. Eisenberg, M.D. Speaker, “Early Clinical Development”, Charlottesville Conference on Traumatic Brain Injury Trials, Charlottesville, Virginia, December 5-7, 1997. Speaker and Panelist, "Prerequisite Objectives for Surgical Education”, Association of Program Directors in Surgery, 1998 Spring Meeting, Baltimore, Maryland; April 22-25, 1998. Panelist, "Preparation of a Scientific Manuscript for Submission to the Journal of Neurosurgery and Neurosurgical Focus: An Update”, 66th Annual Meeting of the American Association of Neurological Surgeons, Philadelphia, Pennsylvania; April 25-30, 1998. Moderator, "Core Curriculum for Trauma/ICU", The Society of Neurological Surgeons, 1998 Annual Meeting, St. Louis, Missouri; May 10, 1998. Faculty Speaker, "Taking the Test: Hints, Tips, Dos, Don’ts”, Oral Neurosurgery Board Preparation Seminar. 48th Congress of Neurological Surgeons, Seattle, Washington; October 5, 1998. Speaker and Panelist, “Having Our Cake And Eating It Too: The Neurosurgeon’s Perspective On Optimizing The PGY-1 Year”. 84th Clinical Congress of the American College of Surgeons, Orlando, Florida; October 26, 1998. Faculty Speaker, “Management of Vestibular Neuromas”, “Gamma Knife Treatment of Metastatic Tumors”, International Winter Congress on Minimally Invasive Techniques for Neurosurgery and Otolaryngology, Aspen, Colorado; March 21-26, 1999. Visiting Professor, The Michael Scott Lecture, “The Impact of New Technologies on Neurosurgery”, Temple University Residents Graduation and The Michael Scott Symposium on Recent Advances in Head and Spinal Injury, Philadelphia, Pennsylvania; June 4, 1999. Visiting Professor, University of California, San Diego, California; June 10, 1999. Speaker, The Injured Brain”, Clinical Pharmacology in Patient Care and Drug Development Symposium, 28th Annual Meeting of the American College of Clinical Pharmacology, Rockville, Maryland; September 16-18, 1999. Chairman, “Early Hemicraniectomy to Manage Traumatic Brain Injury”, first meeting of the Performance/Safety Monitoring Board (PSMB), June 6, 2000, Neuroscience Center, Rockville, MD Reviewer, Reviewed proposals submitted to the New York State Spinal Cord Injury Research Board, chaired by Dr. Faye S. Silverstein, University of Michigan Medical Center, Saratoga Springs, New York, September 11-12, 2000 Speaker, “Contemporary Management of Head Injury-Penetrating Head Injuries”, San Antonio CNS Meeting, September 26, 2000

CURRICULUM VITAE 39 Howard M. Eisenberg, M.D. Speaker, “Database Collection and Data Banks in the USA and in Europe”, Torino, Italy, 4th World Brain Injury Congress, May 2001 - August, 2001 Moderator, “Contemporary Management of Head Injury,” Congress of Neurological Surgeons 51st Annual Meeting, September 29 - October 4, 2001 Visiting Professor, Albany School of Medicine - May 2001 Presidential Address, Senior Society Annual Meeting, Cleveland, OH, 2001 Donald D. Matson Lectureship, Harvard University - May 2002 Wagner Lectureship, New Jersey School of Medicine - 2002 Visiting Professor, Louisiana State University School of Medicine - 2002 16th Annual Marshall Lectureship, The University of Toronto - 2003 Speaker, Seminar Robotic in Neurosurgery AANS Annual Meeting - 2004 Visiting Professor, University of Illinois, November 2004 2nd International Congress on Neuroregeneration, Rio de Janeiro, brazil “Lessons from Clinical Trials of CNS Trauma - September 2004 19th Annual Eldridge Campbell Lecture, Albany Medical College - May 2005 NIH Peer Review, 2005 ABNS Guest Examiner (Former Director), May 2006 Am Soc Ped NS, Resident Training with Exposure - Great Exuma, Bahamas, February 2006 NIH, Improving Functional Outcome, Review Committee - April 2006 Reviewer, NIH Study Section Review; K99/R00, July 2007 Invited Speaker, Taiwan Congress, September 2007 Reviewer, NIH Study Section Review, K99/R00, April 2008 Invited Speaker, Brain MRgFUS Workshop Program, March 2009 Invited Speaker, Society of Neurological Surgeons Annual Meeting, May 2009

CURRICULUM VITAE 40 Howard M. Eisenberg, M.D. First Alumni Visiting Professor, Brigham and Women’s Hospital, Harvard University, Boston, MA, September 2010 Consultant and Visiting Professor, Anshan Changda Hospital, Beijing, China, October 2010 Visiting Professor, Grand Rounds Lecturer, Johns Hopkins University School of Medicine, Baltimore, MD, November 2010 Snodgras Visiting Professor, University of Texas Medical Branch, Galveston, TX, March 2011 Visiting Professor, Wayne State University, Detroit, MI, July 2011 Visiting Professor, New York Hospital Cornell, New York, NY, November 2011