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8/13/2019 721Wk03 Introduction to IV Admixture and Aseptic Technique
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Background
Parenteral: injected through skin or otherexternal boundary tissue, alongside of small
intestine Uses:
NPOnothing by mouth
Unstable in GI, 1stpass metabolism
Immediate action needed
Delivery to specific site
Depot form
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Definitions
LVP-large volume parenteral (>100 ml)
piggy back smaller volume (may be up
to 250 ml)
D5W (5% dextrose in water)
NS (normal saline) 0.9%NaCl
Compounded Sterile Preparation (CSP)
Continuous infusion vs. intermittent dosing
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Definitions
HEPA filter- High Efficiency Particulate Air
0.3 micron, 99.97%
ISO: International Organization forStandardization
ISO 5: Clean room standards based on
particles for cubic meter by particle size Class 100: number of particles 5 m per
cubic foot
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Hood types
Horizontal LaminarAirflow Workbench
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Hood Types
Vertical LaminarAirflow Workbench
(Biosafety)
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Hood Types
Barrier Isolator
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USP 797 Risk Levels
High (3) Nonsterile ingredients
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Clean room
Video
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Syringes and Needles
Parts of syringe (32.12) Barrel
Plunger Tip
Parts of needle (32.12)
Bevel Shaft
Hub
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Injection technique
Critical sites
Swabbing
Bevel up, angle
Equalize pressure
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IV Preparation
Preparation Calculations Assembly
Cleaning Inspection
Expiration dates Quality
Manipulation Inspection
Quality
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References and Resources
USP, Proposed Revisions to USP Chapter http://www.usp.org/healthcareInfo/pharmInfo/revisions797.html
ASHP Self Assessment Tool for Compounding Sterile Preparationshttp://www.ashpbestpracticessat.com/Print_Version_ASHP_797_Assessment.pdf
Ockerman AV, U.S. Pharmacist, Compounded Sterile Preparations:An Overview of the New Standards USP http://www.uspharmacist.com/index.asp?show=article&page=8_1252.htm
ASHP Guidelines on Quality Assurance for Pharmacy-PreparedSterile Products, Am J Health-Syst Pharm, 2000;57:1150-69
http://www.usp.org/healthcareInfo/pharmInfo/revisions797.htmlhttp://www.ashpbestpracticessat.com/Print_Version_ASHP_797_Assessment.pdfhttp://www.ashpbestpracticessat.com/Print_Version_ASHP_797_Assessment.pdfhttp://www.uspharmacist.com/index.asp?show=article&page=8_1252.htmhttp://www.uspharmacist.com/index.asp?show=article&page=8_1252.htmhttp://www.uspharmacist.com/index.asp?show=article&page=8_1252.htmhttp://www.uspharmacist.com/index.asp?show=article&page=8_1252.htmhttp://www.ashpbestpracticessat.com/Print_Version_ASHP_797_Assessment.pdfhttp://www.ashpbestpracticessat.com/Print_Version_ASHP_797_Assessment.pdfhttp://www.usp.org/healthcareInfo/pharmInfo/revisions797.html