Hollow fiber dialyser for efficient high-flux and low-flux dialysis

Hae

mod

ialy

sis

Hae

mod

ialy

sis

Haemodialysis

B. Braun Avitum AG

Schwarzenberger Weg 73–79D-34212 MelsungenGermanyTel +49 (0)56 61 71-26 24Fax +49 (0)56 61 75-26 24

e-mail: dialysis@bbraun.comwww.bbraun-dialysis.comW. 03.01.09/1 Nr. 708 0138A Edition: 01/2009

5

Proven in clinical applications

Administered dialysis dose (eKt/V)

eKt/VeKt/V

1.40

1.00

1.20

High-flux dialysers Low-flux dialysers

1.40

1.00

1.20

0.80 0.80

LO PS 18FX 10HI PS 18 FX 80

eKt/V: equilibrated Kt/V

Values are mean values over a period of four months each.

Administered heparin

52.0

46.0

49.0

I.U./kg

43.01 month2 5 6 7 843

FX 80 FX 10 LO PS 18HI PS 18

Administered heparin doses remain stable throughout the study. No significant changesoccur following the change in dialyser, and heparin requirements remain constant.

Erythropoietin (EPO) and haemoglobin (Hb)

9,500

10,500

8,5001 2 5 6 7 843

High-flux dialysers

11.0

11.5

12.0

10.5

12.5

10.0

I.U./week (EPO) g/dl (Hb)

FX 80FX 80 HI PS 18HI PS 18

EPO

Hb

Low-flux dialysers

7,500

9,500

5,5001 2 5 6 7 843

11.0

11.75

12.5

10.25

13.25

9.5

I.U./week (EPO) g/dl (Hb)

FX 10FX 10 LO PS 18LO PS 18

EPOHb

For the high-flux dialysers, both haemoglobin and erythropoietin values yield a continuouscurve throughout the study. The conversion from FX to Diacap® did not result in any significant changes. The curve confirms that it is not necessary to administer additional EPOif the haemoglobin is stable. This in turn confirms the high dialysis quality.

If low-flux dialysers are used, slightly lower EPO doses result in the expected correspon-dingly slight decrease in haemoglobin.

This relationship is illustrated by the EPO resistance index shown below.

High-flux dialysers

Data of 55 patients (25 female, 30 male) was collected overa period of 8 months. Mean age was 62.5 years, whereasmean body weight and height were 68 kg and 164.0 cmrespectively.

Data was collected at three dialysis centres. During the first 3 months, the patients were treated with the FX 80 high-flux(surface 1.8 m2) dialyser by Fresenius Medical Care.

As of the first week of the fourth month of treatment, thepatients were converted to the Diacap® � Polysulfone HI PS 18(surface 1.8 m2) dialyser by B. Braun Avitum.

Low-flux dialysers

Data of 45 patients (18 female, 27 male) was collected overa period of 8 months. Mean age was 73.6 years, whereasmean body weight and height were 60.6 kg and 159.5 cm respectively.

Data was collected at three dialysis centres. During the first 3 months, the patients were treated with the FX 10 low-flux(surface 1.8 m2) dialyser by Fresenius Medical Care.

As of the first week of the fourth month of treatment, thepatients were converted to the Diacap® � Polysulfone LO PS 18(surface 1.8 m2) dialyser by B. Braun Avitum.

ERIERI

12.5

9.5

11.0

High-flux dialysers Low-flux dialysers

12.5

9.5

11.0

8.0 8.0

LO PS 18FX 10

HI PS 18 FX 80

ERI calculation: EPO dose per week / kg of body weight / haemoglobin in g/dlValues are mean values over a period of four months each.

EPO resistance index (ERI)

Consistently high dialysis qualityTested in practice and proven in studies

Description of the study

diacap_polysulfone_6s_gb.qxp:6-Seiter A4 14.01.2009 10:29 Uhr Seite 4