University of Groningen

68Ga-PSMA PET-CT Imaging of Metastatic Adenoid Cystic Carcinomade Keizer, Bart; Krijger, Gerard C; Ververs, F Tessa; van Es, Robert J J; de Bree, Remco;Willems, StefanPublished in:Nuclear medicine and molecular imaging

DOI:10.1007/s13139-016-0445-6

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Publication date:2017

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Citation for published version (APA):de Keizer, B., Krijger, G. C., Ververs, F. T., van Es, R. J. J., de Bree, R., & Willems, S. (2017). 68Ga-PSMAPET-CT Imaging of Metastatic Adenoid Cystic Carcinoma. Nuclear medicine and molecular imaging, 51(4),360-361. https://doi.org/10.1007/s13139-016-0445-6

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INTERESTING IMAGE ISSN (print) 1869-3482ISSN (online) 1869-3474

Bart de Keizer1 & Gerard C. Krijger1 & F. Tessa Ververs2 & Robert J. J. van Es3 &

Remco de Bree3 & Stefan Willems4

Received: 28 April 2016 /Revised: 23 June 2016 /Accepted: 27 July 2016 /Published online: 16 August 2016# The Author(s) 2016. This article is published with open access at Springerlink.com

Abstract A patient with a history of adenoid cystic carci-noma of the nasal cavity presented himself with bone painand an elevated PSA level. On suspicion of metastaticprostate cancer a 68Ga-PSMA PET-CT was performed.The PET-CT showed numerous lung and non-scleroticbone metastasis. Biopsy of a bone metastasis was per-formed and pathology showed adenoid cystic carcinomainstead of prostate cancer. Immunohistochemical PSMAstaining of the primary tumour showed intense PSMA ex-pression in adenoid cystic carcinoma tumour cells.Because of the high PSMA expression of adenoid cysticcarcinoma, 68Ga-PSMA PET-CT might be a promising im-aging modality for this malignancy.

Keywords Adenoid Cystic . Carcinoma . (68)Ga-PSMA .

Immunohistochemistry . PET-CT

Compliance with Ethical Standards

Conflict of interest Bart de Keizer, Gerard Krijger, Tessa Ververs,Robert van Es, Remco de Bree and StefanWillems declare that they haveno conflict of interest.

Fig. 1 Sagittal (a) and axial (b) fused PET-CT images and coronalmaximum intensity projection of 68GA-PSMA PET (c) showing intensePSMA binding in adenoid cyst ic carc inoma metas tases .Immunohistochemistry of the primary tumour showed intense PSMAexpression mainly in adenoid cystic carcinoma tumour cells (d, arrows)

* Bart de Keizerb.dekeizer@umcutrecht.nl

1 Department of nuclear medicine and radiology, UMC Utrecht, roomE01.132, Heidelberglaan 100, 3584 CX Utrecht, Netherlands

2 Department of clinical pharmacy, UMC Utrecht,Utrecht, Netherlands

3 Department of head and neck surgical oncology, UMC Utrecht,Utrecht, Netherlands

4 Department of pathology, UMC Utrecht, Utrecht, Netherlands

Nucl Med Mol Imaging (2017) 51:360–361DOI 10.1007/s13139-016-0445-6

68Ga-PSMA PET-CT Imaging of Metastatic AdenoidCystic Carcinoma

Ethical statement The study was approved by an institutional reviewboard or equivalent and has been performed in accordance with the eth-ical standards laid down in the 1964 Declaration of Helsinki and its lateramendments. All subjects in the study gave written informed consent orthe institutional review board waived the need to obtain informedconsent.

Open Access This article is distributed under the terms of the CreativeCommons At t r ibut ion 4 .0 In te rna t ional License (h t tp : / /creativecommons.org/licenses/by/4.0/), which permits unrestricted use,distribution, and reproduction in any medium, provided you give appro-priate credit to the original author(s) and the source, provide a link to theCreative Commons license, and indicate if changes were made.

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