5.1b. Post-contrast Coronal T1 Wtd MRI5.1a. Post-contrast Axial T1 Wtd MRI

A 52 year-old male with corpus callosal tumor.

Q1. Diagnosis Please

5.2. Post-contrast Coronal T1 Wtd MRI

A 60 year-old male with known hemopoetic systemic disease.

Q2. Diagnosis Please

5.3. Post-contrast Axial T1 Wtd MRI

A 35 year-old female with multiple cranial nerve neuropathy.

Q3. Diagnosis Please

5.1a. Post-contrast Axial T1 Wtd MRI 5.2. Post-contrast Coronal T1 Wtd MRI 5.3. Post-contrast Axial T1 Wtd MRI

Figures 5.1 – 5.3 are produced by a hemopoetic tumor.

Diagnosis: ?

5.1a. Post-contrast Axial T1 Wtd MRI 5.2. Post-contrast Coronal T1 Wtd MRI 5.3. Post-contrast Axial T1 Wtd MRI

Figures 5.1 – 5.3 are produced by a hemopoetic tumor.

Diagnosis: Lymphoma

5.1b. Post-contrast Coronal T1 Wtd MRI5.1a. Post-contrast Axial T1 Wtd MRI

Figure 5.1. Homogeneously enhancing tumor is seen involving the splenium of the corpus callosum (arrows) spreading across the midline.

Diagnosis: Primary Lymphoma of the brain

5.2. Post-contrast Coronal T1 Wtd MRI

Figure 5.2.

Diagnosis: Secondary Lymphoma with calvarial involvement (green arrow) and associated epidural tumor (yellow arrows) / scalp tumor (red arrow)

5.3. Post-contrast Axial T1 Wtd MRI

Figure 5.3. Linear enhancement of the cerebellar sulci (yellow arrows) and left temporal sulci (red arrow).

Diagnosis: Secondary Lymphoma with subarachnoid tumor seeding (arrows).

Central Nervous System Lymphoma

• Primary lymphoma of the brain is rare, accounts for less than 3.5% of primary brain tumors.

• Non-Hodgkin’s Lymphoma, usually B-cell lymphoma.

• Can be seen in patients with AIDS.

• Tumor intensely enhances with contrast. Common sites of involvement include:

• Basal ganglia/thalamus

• Corpus Callosum

• Periventricular white matter

• Lymphoma responds well to chemo-radiation therapy.

• Open or stereotactic biopsy is necessary to establish the diagnosis.

•Complete surgical resection of the tumor is not necessary as they respond well to chemo-radiation therapy