1
7. Uliel S, Tauman R, Greenfeld M, Sivan Y. Normal polysomnographic respiratory values in children and adolescents. Chest 2004;125:872-8. 8. Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed. Hillsdale, NJ: Lawrence Earlbaum; 1988. 9. Gozal D, Kheirandish-Gozal L. Neurocognitive and behavioral morbid- ity in children with sleep disorders. Curr Opin Pulm Med 2007;13:505-9. 10. Brockmann PE, Urschitz MS, Schlaud M, Poets CF. Primary snoring in school children: prevalence and neurocognitive impairments. Sleep Breath 2011. Epub ahead of print. 11. Bourke R, Anderson V, Yang JS, Jackman AR, Killedar A, Nixon GM, et al. Cognitive and academic functions are impaired in children with all severities of sleep-disordered breathing. Sleep Med 2011;12:489-96. 12. Gottlieb DJ, Chase C, Vezina RM, Heeren TC, Corwin MJ, Auerbach SH, et al. Sleep-disordered breathing symptoms are associated with poorer cognitive function in 5-year-old children. J Pediatr 2004;145:458-64. 13. Urschitz MS, Guenther A, Eggebrecht E, Wolff J, Urschitz-Duprat PM, Schlaud M, et al. Snoring, intermittent hypoxia and academic performance in primary school children. Am J Respir Crit Care Med 2003;168:464-8. 14. Olde Dubbelink KT, Felius A, Verbunt JP, van Dijk BW, Berendse HW, Stam CJ, et al. Increased resting-state functional connectivity in obese adolescents: a magnetoencephalographic pilot study. PLoS ONE 2008; 3:e2827. 15. Rhodes SK, Shimoda KC, Waid LR, O’Neil PM, Oexmann MJ, Collop NA, et al. Neurocognitive deficits in morbidly obese children with obstructive sleep apnea. J Pediatr 1995;127:741-4. 16. Liu X, Forbes EE, Ryan ND, Rofey D, Hannon TS, Dahl RE. Rapid eye movement sleep in relation to overweight in children and adolescents. Arch Gen Psychiatry 2008;65:924-32. 17. Hannon TS, Lee S, Chakravorty S, Lin Y, Arslanian SA. Sleep-dis- ordered breathing in obese adolescents is associated with visceral adiposity and markers of insulin resistance. Int J Pediatr Obes 2011;6:157-60. 18. Mokhlesi B. Obesity hypoventilation syndrome: a state-of-the-art review. Respir Care 2010;55:1347-62. 19. Fiorino EK, Brooks LJ. Obesity and respiratory diseases in childhood. Clin Chest Med 2009;30:601-8. 50 Years Ago in THE JOURNAL OF PEDIATRICS Auscultation in the Diagnosis of Intracardiac Acyanotic Congenital Heart Disease Kaplan S, Daoud G. J Pediatr 1961;60:746-53 I n an article as true today, with some minor exceptions, as it was in 1961, Kaplan and Daoud describe the auscultatory findings in atrial septal defect, ventricular septal defect, endocardial cushion defect, aortic stenosis, and pulmonic stenosis. These descriptions are based on precise correlations of cardiac catheterization pressure recordings with pho- nocardiograms. At the time, the emerging technical advances related to both cardiac surgery and catheterization made accurate diagnosis of congenital heart disease in youth critically important. Studies of school-based screening for con- genital defects with tape recordings were conducted in the 1960s. In the 1980s, skilled auscultation was determined to have a sensitivity and specificity for distinguishing children with normal hearts from children with congenital heart defects <95% to 98%, test characteristics rarely achieved in clinical medicine today. Why then, in an era when phonocardiograms can be found on the internet, do attempts to teach auscultation “fall on deaf ears”? One certain reason is expressed by Kaplan and Daoud: “Cardiac auscultation is an art in which com- petence is acquired with experience and effort.” Because primary correction of congenital heart defects occurs in infancy and rheumatic heart disease (another excellent source of chronic murmurs) is no longer highly prevalent, the number of patients with pathologic murmurs is dramatically reduced, thus the ability to experience these murmurs in training or in practice has declined. A second reason is the emergence of echocardiography as an accurate diagnostic tool. Less well-appreciated is echocardiograms having much poorer specificity, because of the diagnosis of many tran- sient or insignificant conditions. Third, as discussed by Kaplan and Daoud, auscultation is only marginally useful in chronic follow-up of patients. Although the clinical role of auscultation is diminished, it remains an extraordinarily useful, though underused, diagnostic skill. Hundreds of thousands of echocardiograms would not be done and millions of health care dollars would be saved if findings of an innocent murmur or the recognition of a variably split second heart sound were given the diagnostic prominence they deserve. If only there was a way to put auscultation on board certification exams.. Samuel S. Gidding, MD Nemours Cardiac Center A. I. DuPont Hospital for Children Wilmington, Delaware 10.1016/j.jpeds.2011.11.045 May 2012 ORIGINAL ARTICLES Relationships among Obstructive Sleep Apnea, Anthropometric Measures, and Neurocognitive Functioning in Adolescents with Severe Obesity 735

50 Years Ago in The Journal of Pediatrics: Auscultation in the Diagnosis of Intracardiac Acyanotic Congenital Heart Disease

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May 2012 ORIGINAL ARTICLES

7. Uliel S, Tauman R, Greenfeld M, Sivan Y. Normal polysomnographic

respiratory values in children and adolescents. Chest 2004;125:872-8.

8. Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed.

Hillsdale, NJ: Lawrence Earlbaum; 1988.

9. Gozal D, Kheirandish-Gozal L. Neurocognitive and behavioral morbid-

ity in children with sleep disorders. Curr Opin PulmMed 2007;13:505-9.

10. Brockmann PE, Urschitz MS, Schlaud M, Poets CF. Primary snoring in

school children: prevalence and neurocognitive impairments. Sleep

Breath 2011. Epub ahead of print.

11. Bourke R, Anderson V, Yang JS, Jackman AR, Killedar A, Nixon GM,

et al. Cognitive and academic functions are impaired in children with

all severities of sleep-disordered breathing. Sleep Med 2011;12:489-96.

12. Gottlieb DJ, Chase C, Vezina RM, Heeren TC, CorwinMJ, Auerbach SH,

et al. Sleep-disordered breathing symptoms are associated with poorer

cognitive function in 5-year-old children. J Pediatr 2004;145:458-64.

13. Urschitz MS, Guenther A, Eggebrecht E, Wolff J, Urschitz-Duprat PM,

SchlaudM, et al. Snoring, intermittent hypoxia and academic performance

in primary school children. Am J Respir Crit Care Med 2003;168:464-8.

Relationships among Obstructive Sleep Apnea, Anthropometric MAdolescents with Severe Obesity

14. Olde Dubbelink KT, Felius A, Verbunt JP, van Dijk BW, Berendse HW,

Stam CJ, et al. Increased resting-state functional connectivity in obese

adolescents: a magnetoencephalographic pilot study. PLoS ONE 2008;

3:e2827.

15. Rhodes SK, Shimoda KC, Waid LR, O’Neil PM, Oexmann MJ,

Collop NA, et al. Neurocognitive deficits in morbidly obese children

with obstructive sleep apnea. J Pediatr 1995;127:741-4.

16. Liu X, Forbes EE, Ryan ND, Rofey D, Hannon TS, Dahl RE. Rapid eye

movement sleep in relation to overweight in children and adolescents.

Arch Gen Psychiatry 2008;65:924-32.

17. Hannon TS, Lee S, Chakravorty S, Lin Y, Arslanian SA. Sleep-dis-

ordered breathing in obese adolescents is associated with visceral

adiposity and markers of insulin resistance. Int J Pediatr Obes

2011;6:157-60.

18. Mokhlesi B. Obesity hypoventilation syndrome: a state-of-the-art

review. Respir Care 2010;55:1347-62.

19. Fiorino EK, Brooks LJ. Obesity and respiratory diseases in childhood.

Clin Chest Med 2009;30:601-8.

50 Years Ago in THE JOURNAL OF PEDIATRICS

Auscultation in the Diagnosis of Intracardiac Acyanotic Congenital Heart DiseaseKaplan S, Daoud G. J Pediatr 1961;60:746-53

In an article as true today, with someminor exceptions, as it was in 1961, Kaplan andDaoud describe the auscultatoryfindings in atrial septal defect, ventricular septal defect, endocardial cushion defect, aortic stenosis, and pulmonic

stenosis. These descriptions are based on precise correlations of cardiac catheterization pressure recordings with pho-nocardiograms. At the time, the emerging technical advances related to both cardiac surgery and catheterization madeaccurate diagnosis of congenital heart disease in youth critically important. Studies of school-based screening for con-genital defects with tape recordings were conducted in the 1960s. In the 1980s, skilled auscultation was determined tohave a sensitivity and specificity for distinguishing children with normal hearts from children with congenital heartdefects <95% to 98%, test characteristics rarely achieved in clinical medicine today.

Why then, in an era when phonocardiograms can be found on the internet, do attempts to teach auscultation “fallon deaf ears”? One certain reason is expressed by Kaplan and Daoud: “Cardiac auscultation is an art in which com-petence is acquired with experience and effort.” Because primary correction of congenital heart defects occurs ininfancy and rheumatic heart disease (another excellent source of chronic murmurs) is no longer highly prevalent,the number of patients with pathologic murmurs is dramatically reduced, thus the ability to experience these murmursin training or in practice has declined. A second reason is the emergence of echocardiography as an accurate diagnostictool. Less well-appreciated is echocardiograms having much poorer specificity, because of the diagnosis of many tran-sient or insignificant conditions. Third, as discussed by Kaplan and Daoud, auscultation is only marginally useful inchronic follow-up of patients.

Although the clinical role of auscultation is diminished, it remains an extraordinarily useful, though underused,diagnostic skill. Hundreds of thousands of echocardiograms would not be done and millions of health care dollarswould be saved if findings of an innocent murmur or the recognition of a variably split second heart sound were giventhe diagnostic prominence they deserve. If only there was a way to put auscultation on board certification exams..

Samuel S. Gidding, MDNemours Cardiac Center

A. I. DuPont Hospital for ChildrenWilmington, Delaware

10.1016/j.jpeds.2011.11.045

easures, and Neurocognitive Functioning in 735