5th International Workshop On The Treatment Of Hepatic And Lung Metastases Of Colorectal Carcinoma

www.oncology-bcn.com

November 12th and 13th, 2015.Hotel NH Barcelona Constanza. Barcelona, Spain.

5th International Workshop On The Treatment Of Hepatic And Lung Metastases Of Colorectal Carcinoma

November 12th and 13th, 2015.Hotel NH Barcelona Constanza. Barcelona, Spain.

Organised by:

Fundació Docència i Recerca MútuaTerrassa

The most common metastasic localizations of colorectal cancer occur in the liver and

the lungs. Multidisciplinary treatment of patients suffering from metastasic localization

of colorectal cancer has shown encouraging results in improving the chances for a cure.

The Workshop is focusing on the state-of-the art of the multimodal management of

lung and liver metastases.

We invite you to activaly participate In the scientific programme.

We look forward to a memorable meeting and hope to see you in Barcelona!

Dr. Lluís CireraWhorkshop Chairman

www.oncology-bcn.com

Dr. Esteban Cugat Dr. Ramón Rami-PortaWorkshop’s Vice-Chairmen

CommiteesWorkshop coordinators:Chairman: Lluís Cirera

Vice-Chairmen: Esteban Cugat, Ramón Rami-Porta

Organizing committee:José Belda

Sergi Call

Esther Casado

Lluís Cirera

Esteban Cugat

Julen Fernández

Carmen Ferrer

Maribel García

Eric Herrero

José Angel de Marcos

Ramón Rami-Porta

Antonio Salas

Scientific committee:Rene Adam

Sergi Call

Lluís Cirera

Esteban Cugat

Joan Figueras

Jesús García-Foncillas

Clara Montagut

Ramón Rami-Porta

Programme

Programme Thursday, November 12th, 2015

10.00 Registration

10.45- 11.00 Welcome and Presentation Lluís Cirera

11.00- 14.00 SPONSORED SYMPOSIUMS

14.10- 15.10 Lunch

14.10- 20.00 POSTER DISPLAY

15.45- 17.00 INTERACTIVE SESSION 1: Clinical case with multidisciplinary team discussion Patient with liver metastases and… Moderators: Lluís Cirera and Esteban Cugat

15.45- 16.00 Intensive vs sequencial chemotherapy Fotios Loupakis

16.00- 16.15 R1 surgery Rene Adam

16.15- 16.30 Extreme surgery Joan Figueras

16.30- 16.45 ALPPS Julio Santoyo

16.45- 17.00 Molecular classification of CRC Miriam Cuatrecasas

17.00- 18.00 LECTURES Introduction: Esteban Cugat

17.00- 17.20 Liver transplantation in metastasic setting: an update Rene Adam

17.20- 17.30 Questions

17.30- 17.50 Functional assessment of rapidly growing liver Eric Schadde

17.50- 18.00 Questions

18.00- 18.30 Coffee Break

18.30- 19.40 LIVER METASTASES Moderators: Joan Figueras and Emilio Ramos

18.30- 18.45 Portal embolization Juan Carlos García-Valdecasas

18.45- 19.00 Laparoscopic surgery Ricardo Robles

19.00- 19.15 Robotic surgery Emilio de Vicente

19.15- 19.30 Surgical resection after second-line chemotherapy with aflibercept: Spanish experience Nuría Rodríguez

19.30- 19.40 Discussion

19.40- 20.20 LOCO-REGIONAL TREATMENTS Moderators: Esteban Cugat and Juan Carlos García-Valdecasas

19.40- 19.55 Radioembolization of liver metastases. A bridge to surgery Fernando Pardo

19.55- 20.10 Intraarterial treatments; an update Joan Falcó

20.10- 20.20 Questions

Programme Friday, november 13th, 201508.00- 09.25 INTERACTIVE SESSION 2: Clinical case with multidisciplinary team discussion Two patients with lung metastases, with complete response after oncologic treatment Moderators: Sergi Call and Esther Casado

08.00- 08.30 Clinical case presentation: Sergi Call and Esther Casado Expert opinión

08.30- 08.45 Surgical plan based on risk factors Raul Embún

08.45- 09.00 Role of targeted therapies Carles Pericay

09.00- 09.15 Lung metastasectomy after complete response? Paul Van Schil

09.15- 09.25 Discussion

09.25- 09.55 LECTURE Introduction: Lluís Cirera

09.25- 09.45 Liquid biopsy: present and future Jesús García-Foncillas

09.45- 09.55 Questions

09.55- 10.25 Coffee Break

10.25- 11.35 LUNG METASTASES Moderators: Laureano Molins and Ramón Rami-Porta

10.25- 10.40 What is the best approach in pulmonary metastasectomy? Paul Van Schil

10.40- 10.55 Pulmonary laser resections: Technical aspects and results in colorectal cancer Bernward Passlick

10.55- 11.10 Modeling survival data after lung metastasectomy. Results from the Spanish

Prospective Colorectal Metastasectomy Registry (GECMP-CCR) Raul Embún

11.10- 11.25 Nonexamination of lymph node and survival in lung metastasectomy. Results from

the Spanish Prospective Colorectal Metastasectomy Registry (GECMP-CCR) Sergi Call

11.25- 11.35 Discussion

11.35- 12.05 LECTURE Introduction: Ramón Rami-Porta

11.35-11.55 Accuracy of imaging techniques in the detection of pulmonary metastases Tomasz Grodzki

11.55 – 12.05 Questions

12.05- 13.00 EXTENT OF TUMOR RESPONSE: DOES IT MATTER? Moderators: Esther Casado and Marta Paraira

12.05- 12.20 What does depth response mean? Javier Gallego

12.20- 12.35 What does early tumor shrinkage (ETS) mean? Elena Elez

12.35- 12.50 Relation between radiological and surgical response Emilio Ramos

12.50- 13.00 Discussion

13.00- 13.30 LECTURE Introduction: Julen Fernández

13.00- 13.20 Resistance to anti-EGFR therapy Clara Montagut

13.20- 13.30 Questions

Programme Friday, november 13th, 2015

13.30- 14.00 POSTERS SESSION

Contributions of patient-, tumor-, and treatment-related factors to the patients outcome after curative liver resection among egyptian patients with metastatic colorectal tumorAmr Abdelaal1, khalid Elhusseiny2 , Mona Kamal21Ain Shams University. Faculty of Medicine-general Surgery Department. Egypt. Cairo; 2 Ain Shams University. Faculty of Medicine. Clinical Oncology Department. Egypt. Cairo

The pharmacological costs of complete liver resections in unselected advanced colorectal cancer patients: focus on targeted agents. A review of randomized clinical trialsJacopo Giuliani, Andrea BonettiDepartment of Medical Oncology. Mater Salutis Hospital-AULSS 21 della Regione Veneto, Legnago (VR). Italy

Subcentimeter liver metastases diagnosed intraoperative on colorectal cancerLosada Villa B., De Torres Olombrada MV., Juez Martel I., Gutiérrez abad D., Guerra Martínez J.HU Fuenlabrada. Madrid. Spain

Differential diagnosis between cavernous hemangioma and liver metastases: Importance of Intraoperative ultrasound and biopsyDe Torres Olombrada MV., Losada Vila B., Gutierrez Abad D., Juez Martel I., Pereira Pérez F.H U Fuenlabrada, Madrid, Spain

Recent literature review and individual data meta-analysis for the study of survival after pulmonary metastasectomy in colorectal cancer patients: a history of resected liver metastases worsens the prognosisJon Zabaleta, Tomohiko Iida, Samer Salah, José Ramon Jarabo, Pierre Falcoz, Shanda H Blackmon, Maria G. Zampino, Takashi Matsui, Sukki Cho (84 pac), Francesco Ardissone, Kazuhiro Watanabe, Michel Gonzalez, Pascal Gervaz, Jose I. EmparanzaThoracic Surgery Service, Donostia University Hospital

Oligometastatic colorectal carcinoma (CRC) patients treated with radical intention. Retrospective analysis of the experience in a single centreJulia Hidalgo-Coloma, Sara Marín, Javier Garde-Noguera, René Albino, Beatriz Honrubia, Enrique Cabrera, Juan Manuel CamposHospital Arnau de Vilanova. Valencia. Spain

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14.00- 14.15 BEST POSTER AWARD

14.15 Adjournment Lluís Cirera

14.30 Lunch

Prognosis of lung metastases in colorectal cancerJaione Sáenz de Ugarte Sobrón, José Domingo Sardón Ramos, Baltasar Cermeño Toral, Alberto Gastón Moreno, Paula Siebel Hermida, Iñaki Martínez Rodríguez, Aintzane Maqueda Merino, María Cuadra Cestafe, Lorans Fernández Rico, Ane Etxart LopetegiDepartment of SurgeryAraba-Txagorritxu University Hospital. Basque Country. Spain

Liver only disease of Colorectal cancer: a different disease?Dr. Ana Fernandez Montes1, Dr. Mercedes Salgado1, Dr Manuel Trillo2, Dr. Jose Manuel Carrera2, Dr. Purification Froján3, Dr Alejo Muinello31 Department of Medical Oncology; 2 Department of Radiology; 3 Department of General Surgery. University Hospital Complex Ourense. Spain

Clinical implications of molecular and functional characterization in liver limited metastatic colorectal cancer. Vall d’hebrón university hospital programCarolina Ortiz1, Guillem Argilés1,2, Tamara Saurí1,2, Julieta Grasselli2, Cristina Dopazo1, Teresa Macarulla1,2, Jaume Capdevila1,2, Ignacio Matos1,2, María Alsina1,2, Cinta Hierro1,2, Helena Verdaguer1,2, Enrique Sanz-García1, Stefania Landolfi1, Paolo Nuciforo2, Rodrigo Dienstmann2, Ramón Charco1, Ana Vivancos2, Hector G. Palmer2, Elena Elez1,2 and Josep Tabernero1,21 Vall d’Hebron University Hospital. Barcelona. Spain; 2 Vall d’Hebron Institute of Oncology (VHIO). Barcelona. Spain

Agressive treatment for liver metastasis of squamous cell carcinomaGastón Moreno A, Saez de Ugarte Sobron J, Sardon Ramos J.D, Maqueda Merino A, Siebel Hermida P, Camuera Gonzalez M, Martinez Rodriguez I, Garcés Garmendia M.A, Rebollar Saenz J, Fernandez Rico L.H.U.A Txagorritxu. Vitoria. España

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ParticipantsRenè Adam. Oncosurgical Unit. Hepatobiliary Center. University Paris Sud. Hôpital Paul-Brousse. Paris

Sergi Call. Thoracic Surgery Service. Hospital Universitari MútuaTerrassa. Terrassa. Barcelona

Esther Casado. Oncology Service. Althaia. Xarxa Assistencial de Manresa. Manresa. Barcelona

Lluís Cirera. Oncology and Hematology Service. Hospital Universitari MútuaTerrassa. Terrassa. Barcelona

Miriam Cuatrecasas. Pathology Service. Hospital Clínic. Barcelona

Esteban Cugat. Surgery Service. Hospital Universitari MútuaTerrassa. Terrassa. Barcelona

Elena Elez. Medical Oncology Department. Hospital Vall d´Hebron. Barcelona

Raul Embún. Department of Thoracic Surger. Hospital Universitario Miguel Servet. Zaragoza

Joan Falcó. Vascular and interventional radiology Unit. Corporació Sanitària Parc Taulí. Sabadell. Barcelona

Jaime Feliu. Medical Oncology Service. Hospital Universitario La Paz. Madrid

Julen Fernández. Oncology and Hematology Service. Hospital Universitari MútuaTerrassa. Terrassa. Barcelona

Joan Figueras. Hepatobiliary Surgery Unit. Hospital Universitari Doctor Josep Trueta. Girona

Javier Gallego. Medical Oncology Service. Hospital Universitario Elche. Elche. Alicante

Pilar García-Alfonso. Medical Oncology Service. Hospital Universitario Gregorio Marañón. Madrid

Jesús García-Foncillas. Oncology Department. Fundación Jiménez Díaz. Madrid

Juan Carlos García-Valdecasas. General and Digestive Surgery. Hospital Clínic. Barcelona

Tomasz Grodzki. Pomeranian Medical University. Poland

Fotios Loupakis. Medical Oncology Service Ospedale S. Chiara - Azienda Ospedaliero-Universitaria Pisana. Italy

Teresa Macarulla. Medical Oncology Service. Hospital Universitario Vall d’Hebron. Barcelona

Laureano Molins. Thoracic Surgery Service. Hospital Clínic. Barcelona

Clara Montagut. Oncology Department. Parc de Salut Mar. Hospital del Mar. Barcelona

Marta Paraira. Radiodiagnostic Service. Hospital Universitari MútuaTerrassa. Terrassa. Barcelona

Fernando Pardo. Hepatobiliary Surgery Service. Clínica Universitaria de Navarra. Pamplona. Navarra

Benward Passlik. Department of Thoracic Surgery. Albert-Ludwigs-University Freiburg. Freiburg

Carles Pericay. Medical Oncology Service. Consorci Hospitalari Parc Taulí. Sabadell. Barcelona

Ramón Rami-Porta. Thoracic Surgery Service. Hospital Universitari MútuaTerrassa. Terrassa. Barcelona

Emilio Ramos. General and Digestive Surgery. Hospital Universitari de Bellvitge. L´Hospitalet de Llobregat. Barcelona

Ricardo Robles. Liver transplant Unit. Surgery Service. Hospital Universitario Virgen de la Arrixaca. Murcia

Nuría Rodríguez. Medical Oncology Department. Hospital Universitario La Paz. Madrid

Antonieta Salud. Medical Oncology Service. Hospital Universitario Arnau Villanova. Lleida

Julio Santoyo. General and Digestive Surgery. Hospital Carlos Haya. Málaga

Eric Schadde. Department of Surgery. Swiss HPB ans Transplant Center. University Hospital Zurich. Zurich

Paul Van Schil. Department of Thoracic and Vascular Surgery. University Hospital of Antwerp. Edegem

Ruth Vera. Medical Oncology Service. Complejo Hospitalario de Navarra. Navarra

Emilio de Vicente. Department of General and Digestive Surgery. Hospital Universitario Sanchinarro. Madrid

Sponsored symposiums 11.00- 12.00 Improving overall survival with panitumumab in metastatic colorectal cancer Sponsored by AMGEN

Introduction Jaime Feliu

What is the value of panitumumab in the treatment of metastatic colorectal cancer? Teresa Macarulla

What is the current evidence of panitumumab in the treatment of liver only metastatic colorectal cancer? Ruth Vera

12.00- 13.00 AVASTIN: 10 years provinding outcomes among mCRC patiens Sponsored by Roche

A different treatment approach for mCRC. Unresectable patients Fotios Loupakis

How can we treat unresectable liver metastases with AVASTIN in 2015? Pilar García-Alfonso

Discussion and conclusions Antonieta Salud

13.00- 14.00 Precision medicine, precision treatment Sponsored by Merck Serono

Cetuximab role within surgery of non-resectables metastases Joan Figueras

Standard chemotherapies – are they eligible for all anti-EGFR? Elena Élez

General Information

www.oncology-bcn.com

Dates: November 12th and 13th, 2015. Barcelona, (Spain)

Venue: Hotel NH Barcelona Constanza. St/ Deu i Mata, 69-99. 08029. Barcelona (Spain)

Language: The official languages of the Workshop will be English and Spanish. There will be simultaneous translation.

Technical Secretariat (registration and hotel reservation): ACTO SERVEISC/ Bonaire, 7. 08301 Mataró. Barcelona (Spain).Tel. +34 937 552 382 / Fax. +34 937 552 383info@oncology-bcn.com | www.oncology-bcn.com

PostersThere will be a Euro 1,000.00 award to the best poster according to the evaluation of the Scientific Committee.

RegistrationRegistration Fees

Before September 15th After September 16th andon-site registration

Members of SEOM, GEMCAD, SEPAR, TTD, ESSO, AEC, ACROSS, ESMO, SECT

Others

Residents

650 €

750 €

450 €

690 €

790 €

490 €

*VAT (21% IVA) is included*

Registration documentation will be handed-out to the participants from the Meeting Secretariat.Registration forms will be only processed when received before November 2nd, 2015.After this date registration forms will be processed as on-site registrations.

RegistrationOn-line registration is possible through the web site www.oncology-bcn.comThis service will let you register and receive your confirmation letter on-line.The payment is possible by bank transfer and credit card.

Registration forms received without the complete contact address or without payment will not be accepted. Before November 2nd, 2015 registration will be possible on-site. The fees should be paid in Euros by bank transfer or credit card. Participants must bring the confirmation letter to the registration desk as proof of their registration.

Payment of Registration FeesEarly rates only apply when registration and payment are received before September 15th. When registrations and payments are received after September 16th 2015, then the corresponding late fees will automatically applyPayment in EURO (€) should be made in advance by bank transfer or credit card.

Bank to bank transfer to ACTO SERVEIS in Euro- BANK: BANKINTER- ACCOUNT NUMBER: 0128-0524-24-0100028872- IBAN: ES63 0128-0524-24-0100028872- SWIFT: BKBKESMMXXX- Reference: ACTOSERVEIS

Clearly mention name with the bank transfer.

Remittance should be free of charge to the recipient.

Registration cancellation policyAny cancellation must be notified in writing and will be subjected to the following conditions:Refund of fees: subject to a 25% administrative charge, will be applied to cancellations, made up to October 28th. No refund can be made after October 28th.

AcommodationHotel reservationThe Meeting Secretariat (ACTO SERVEIS) is in charge of hotel accommodation and will operate on a first-come first-served basis with the incoming requests.Due to heavy demand and to the fact that distribution of rooms is limited, accommodation cannot be guaranteed after September 15th, 2015.

Breakfast and VAT included. Prices are per room and nights. Deadline for guaranteed hotel reservations: September 15th, 2015.

The Technical Secretariat reserves the right to book another hotel/category if the desired one is fully booked. If this is necessary, participants will be notified as soon as possible.

Hotel requestOn-line hotel request is possible through the web site www.oncology-bcn.com.This service will let you register and receive your confirmation letter on-line.The payment is possible by bank transfer and credit card.

Hotel forms received without the complete contact address or without payment will not be accepted.

Participants must bring the hotel voucher to the hotel reception as proof of their reservation.

Payment details (Registration and Accommodation)Payment in EURO (€) should be made in advance by bank transfer or credit card.

Bank to bank transfer to ACTO SERVEIS in Euro- Bank: BANKINTER- ACCOUNT NUMBER: 0128-0524-24-0100028872- IBAN: ES63 0128-0524-24-0100028872- SWIFT: BKBKESMMXXX- Reference: ACTOSERVEIS

Single Room

Hotel NH Barcelona Constanza **** (St/ Deu i Mata, 69-99. Barcelona) 143,99€ 164,76€

Double Room

Clearly mention name with the bank transfer.Remittance should be free of charge to the recipient.- Reference: ACTOSERVEIS

Clearly mention name with the bank transfer.Remittance should be free of charge to the recipient.

Hotel Reservation Cancellation PolicyAny cancellation must be notified in writing and will be subjected to the following conditions:Accommodation Refunds: 50 % refund if cancelled before September 2nd, 2015; 25 % refund if cancelled from September 3rd to October 5th 2015; and no refund if cancelled after October 5th, 2015.

Lower Cost Accommodation

Younger visitors and those looking for alternative forms of accommodation will find youth hostels, halls of residence, some of them open all year round. In short, accommodation for all tastes and at prices to suit every pocket.

For more information about the city’s hotels please check the website www.barcelonaturisme.com (where to sleep).

Contact them directly to consult prices for short stays and make the reservation.

City informationBarcelona overlooks the Mediterranean and is located in a heavily populated area which is a hub of economic activity.

Barcelona enjoys a Mediterranean climate, with mild winters and warm summers.

It is a coastal city and has over four kilometres of urban beaches and large areas of nearby forest. Although it is a large city, it is easy to get around on public transport and on foot. You can reach any point in the city by metro, bus and taxi.

Barcelona is the capital of Catalonia. Its inhabitants are open and welcoming.

The people of Barcelona speak Catalan, their own language, and Spanish. Many of them also understand a little English and French

VisaSpain is part of the Schengen zone. This means that nationals from EU countries do not need a visa.

LenguageMost of Barcelona’s inhabitants are bilingual and speak Catalan, their own language, and Spanish.

ElectricityThe voltage in Spain is 220 volts, 50 Hz. The plug types are C and F.

ClimateThe city has a typically Mediterranean climate and enjoys pleasant temperatures all the year round.

CurrencyThe euro (€) is the official currency of the European Union and can be exchanged at savings banks and banks.

BanksBusiness hours differ between banks. Most banks are open from Monday to Friday from 08:15 to 14:15.

CustomsIn Barcelona mealtimes are usually a little later than the rest of Europe. The city’s shops have long opening hours.

Shopping in BarcelonaMonday to Saturday, from 09:30 to 13:30 and from 16:30 to 20:00. Most of the department stores do not close at mid-day.

Notes

www.oncology-bcn.com

Academic support:

This Workshop has been accrediteed with 9 ESMO-MORA points

This Workshop was granted 6 European CME credits (ECMEC) by the European Accreditation Council for Continuing Medical Education (EACCME).

Supported by:

Technical SecretariatACTO SERVEISC/ Bonaire, 7. 08301 Mataró. Barcelona (Spain).Tel. +34 937 552 382 / Fax. +34 937 552 383info@oncology-bcn.com

www.oncology-bcn.com