ii New Patents

zoles and acylsulphonamides) of the formula I and salts thereof, wherein the radicals R1, R2, L, X, Y, Z, A 1, Q, A2 and M have the meanings set out in the specification. The invention also in- cludes pharmaceutical compositions in- corporating a formula I compound or a salt thereof, a process for the manufacture of the said compound, together with intermediates for use in the latter process. See Patent for Chemical Structure I

4859765

SYNTHETIC PEPTIDE S E Q U E N C E S USEFUL IN

BIOLOGICAL AND P H A R M A C E U T I C A L

A P P L I C A T I O N S AND M E T H O D S OF M A N U F A C T U R E

John Nestor, John G Moffatt, t tardy Chan as- signed to Syntex (U S A ) Inc

4859701

A Z U L E N E DERIVATIVES A N D P H A R M A C E U T I C A L

C O M P O S I T I O N S C O N T A I N I N G T H E M

Masabum Yasunami, Kahei Takase~ Takashi Meguro, Katsumi Suzuki, Osamu Hiwatashi, Masaru Okutsu, Nobuo Kato, Toru Nakamura, Sendai, Japan assigned to Ajinomoto Co Inc

Azulene derivatives of the following formula See Patent for Chemical Structure wherein R 1 stands for an alkyl group of 1 to 3 carbon atoms, R2 stands for an alkyl group of I to 3 carbon atoms, and R3 is at the 5- or 6- position and stands for an aikyl group of 1 to 6 carbon atoms, an aryl group of 6 to 9 carbon atoms or an aralkyl group of 7 to 10 carbon atoms; have antihyperlipidemic activity. Many of the compounds are also novel per se.

4859709

P H A R M A C E U T I C A L C O M P O S I T I O N

David A Rawlins, Tewin, United Kingdom as- signed to Beecham Group plc

A pharmaceutical composition comprising a freely flowable powder, the powder comprising a porous, high absorption silica or silicate having absorbed therein at least 10% by volume of a li- quid, pharmaceutically active composition, based on the weight of powder plus liquid, pro- vided that when the liquid pharmaceutically ac- tive composition is a corticoid solution the silica or silicate has a mean particle size of at least 10 mum in diameter.

The present invention relates to novel synthetic antigens, conjugates and antibodies based upon specific peptide sequences and the production thereof. More particularly, the invention relates to a polypeptide which is a determinant site of a protein, the polypeptide having from 8 to 20 amino acid residues, having an amino-terminal amino acid and a carboxyl-terminal amino acid, wherein the polypeptide includes: (a) a four amino acid sequence which corresponds to the four amino acid sequence of a beta-turn of the protein; (b) a sequence of two to eight amino acid residues attached to the amino terminal (H2N-) of the four amino acid sequence; and (c) a sequence of two to eight amino acid residues at- tached to the carboxyl terminal (-COOH) of the four amino acid sequence, wherein the amino acid residues of subparts (b) and (c) correspond to those attached to the amino terminal and the carboxyl terminal, respectively of the beta-turn of the protein, and the pharmaceutically ac- ceptable salts of the polypeptide. The invention relates to a conjugate which comprises the poly- peptide described above with a macromolecular carrier. The invention also relates to antibodies and the production thereof which are specific for the polypeptide or the conjugate of the peptide described above. The synthetic polypeptide sequences, peptide conjugates and antibodies thereof are useful as antigens in the production of vaccines, antiviral agents, diagnostic reagents and the like, for the detection and treatment of infectious and immune diseases such as polio and cancer, and the like in mammals, par- ticularly human beings.

4861415

M A C H I N E FOR M O I S T E N I N G A COVER TO BE FIXED O N T O A BASE FILLED FOR E X A M P L E WITH A P H A R M A C E U T I C A L

P R O D U C T

Ernest Gamberini, Rostignano Pianoro, Italy assigned to MG 2 S p A