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Lelio ORCI Publications - Page 1 -

1. MELIS M. e L. ORCI : La microscopia a contrasto di fase su ultrasezioni di tessuti e le sue applicazioni in biologia. La Ricerca scientifica 4, 365-410 (1964).

2. MELIS M., TROCCOLI R. e L. ORCI : Rilievi istomorfologici ed a contrasto di fase su ultrase-zioni di tessuto, nelle lesioni pancreatiche secondarie ad ulcera gastrica perforante. La Ricerca scientifica 6, 275-292 (1965).

3. AJELLO L., MELIS M. e L. ORCI : Su alcuni aspetti strutturali ed ultra-strutturali della cellula epatica umana nel diabete. Epatologia 12, 43-101 (1966).

4. FORSSMANN W.G., SIEGRIST G., ORCI L., GIRARDIER L., PICTET R. et Ch. ROUILLER (avec l’assistance technique de : BAUMANN M. et A. MORITZ) : Fixation par perfusion pour la microscopie électronique : essai de généralisation. J. Microscopie 6, 279-294(1967).

5. ORCI L., PICTET R. et Ch. ROUILLER : Image ultrastructurale de pinocytose dans la cellule de Kupffer du foie de rat. J. Microscopie 6, 413-418(1967).

6. PICTET R., ORCI L., GONET A.E., ROUILLER Ch. and A.E. RENOLD : Ultrastructural studies of the hyperplastic islets of Langerhans of spiny mice (“Acomys cahirinus”) before and during the development of hyperglycemia. Diabetologia 3, 188-211 (1967).

7. JUNOD A., LAMBERT A.E., ORCI L., PICTET R., GONET A.E. and A.E. RENOLD : Stud-ies of the diabetogenic action of streptozotocin. Proc. Soc. Exper. Biol. & Med. 126, 201-205 (1967).

8. ORCI L., JUNOD A., PICTET R., RENOLD A.E. and Ch. ROUILLER : Granulolysis in A-cells of endocrine pancreas in spontaneous and experimental diabetes in animals. J. Cell Biol. 38, 462-466 (1968).

9. ORCI L., PICTET R., FORSSMANN W.G., RENOLD A.E. and Ch. ROUILLER: Structural evidence for glucagon producing cells in the intestinal mucosa of the rat. Diabetologia 4, 56-67 (1968).

10. MATTER A., ORCI L., FORSSMANN W.G. and Ch. ROUILLER : The stereological analysis of the fine structure of the “micropinocytosis vermiformis” in Kupffer cells of the rat. J. Ultrastr. Res. 23, 272-279(1968).

11. PICTET R., JEANRENAUD B., ORCI L., RENOLD A.E. et Ch. ROUILLER : Cellules adipeuses «in situ» et isolées. Essai de fixation pour la microscopie électronique. Z. Ges. Exp. Med. 148, 255-274 (1968).

12. MATTER A., ORCI L. and Ch. ROUILLER : A study on the permeability barriers between Disse’s space and the bile canaliculus. J. Ultrastr. Res., Suppl. 11, 1-71 (1969).

13. FORSSMANN W.G., ORCI L., PICTET R., RENOLD A.E. and Ch. ROUILLER: The endocrine cells in the epithelium of the gastrointestinal mucosa of the rat. An electron microscopical study. J. Cell Biol. 40, 692-715 (1969).

14. PICTET R., ORCI L., FORSSMANN W.G. and L. GIRARDIER : An electron study of the per-fusion-fixed spleen. I. The splenic circulation and the RES concept. Z. Zellforsch. 96, 372-399 (1969).

15. PICTET R., ORCI L., FORSSMANN W.G. and L. GIRARDIER : An electron microscope study of the perfusion-fixed spleen. II. Nurse cells and erythrophagocytosis. Z. Zellforsch. 96, 400-417 (1969).


16. ORCI L., LAMBERT A.E., ROUILLER Ch., RENOLD A.E. and E. SAMOLS : Evidence for the presence of A-cells in the endocrine fetal pancreas of the rat. Horm. & Met. Res. 1, 108-110 (1969).

17. FORSSMANN W.G. and L. ORCI : Ultrastructure and secretory cycle of the gastrin-producing cell. Z. Zellforsch. 101, 419-432 (1969).

18. ORCI L., LAMBERT A.E., KANAZAWA Y., RENOLD A.E. and Ch. ROUILLER: Organ cul-ture of fetal-rat pancreas. III. Ultrastructural changes occurring in B-cells during stimulation of insulin release. Chem.-Biol. Interactions 1, 341-359 (1969/1970).

19. ORCI L., STAUFFACHER W., DULIN W.E., RENOLD A.E. and Ch. ROUILLER : Ultrastruc-tural changes in A-cells exposed to diabetic hyperglycaemia. Observations made on pancreas of Chinese hamsters. Diabetologia 6, 199-206 (1970).

20. STAUFFACHER W., ORCI L., AMHERDT M., BURR I.M., BALLANT L., FROESCH E.R. and A.E. RENOLD : Metabolic state, pancreatic insulin content and B-cell morphology of normo-glycemic spiny mice (“Acomys cahirinus”) : Indications for an impairment of insulin secretion. Diabetologia 6, 330-342 (1970).

21. ORCI L., STAUFFACHER W., AMHERDT M., PICTET R., RENOLD A.E. and Ch. ROUILLER : The kidney of spiny mice (Acomys cahirinus) : Electron microscopy of glomerular changes associated with ageing and tubular glycogen accumulation during hyperglycemia. Diabetologia 6, 343-355 (1970).

22. PERRELET A., ORCI L. and F. BAUMANN : Evidence for granulolysis in the retinula cells of a stomatopod crustacean, “Squilla mantis”. J. Cell Biol. 48, 684-688 (1971).

23. ORCI L., MATTER A. and Ch. ROUILLER : A comparative study of freeze-etch replicas and thin sections of rat liver. J. Ultrastr. Res. 35, 1-19(1971).

24. LAMBERT A.E., KANAZAWA Y., ORCI L., BURR I.M., CHRISTENSEN H.N. and A.E. RENOLD : Stimulation of insulin release «in vitro» by non-metabolized amino acid analogues. Proc. Soc. Exp. Biol. & Med. 137, 377-381 (1971).

25. ORCI L., STAUFFACHER W., RUFENER C., LAMBERT A.E., ROUILLER Ch. and A.E. RENOLD : Acid phosphatase activity in secretory granules of pancreatic Beta cells of normal rats. Diabetes 20, 385-388 (1971).

26. AMHERDT M., ORCI L., TRACK N.S., LAMBERT A.E., KANAZAWA Y. and W. STAUF-FACHER : An ultrastructural study of the islet cell tumor of the golden hamster. Horm. & Met. Res. 3, 252-258 (1971).

27. KANAZAWA Y., ORCI L. and A.E. LAMBERT : Organ culture of fetal rat pancreas. IV. Effects of metabolic inhibitors on insulin release. Endocrinology 89, 576-583 (1971).

28. ORCI L., LAMBERT A.E., KANAZAWA Y., AMHERDT M., ROUILLER Ch. and A.E. RE-NOLD : Morphological and biochemical studies of B-cells of fetal rat endocrine pancreas in organ culture. Evidence for (pro)insulin biosynthesis. J. Cell Biol. 50, 565-582 (1971).

29. ORCI L. and W. STAUFFACHER : Glycogenosomes in renal tubular cells of diabetic animals. J. Ultrastr. Res. 36, 499-503 (1971).

Lelio ORCI Publications - Page 3 -30. LAMBERT A.E., BLONDEL B., KANAZAWA Y., ORCI L. and A.E. RENOLD : Monolayer

cell culture of neonatal rat pancreas : light microscopy and evidence for immunoreactive insulin synthesis and release. Endocrinology 90, 239-248 (1972).

31. ORCI L., GABBAY K.H. and W.J. MALAISSE : Pancreatic beta-cell web : its possible role in insulin secretion. Science 175, 1128-1130 (1972).

32. LIKE A.A. and L. ORCI : Embryogenesis of the human pancreatic islets : A light and electron microscopic study. Diabetes 21, suppl. 2, 511-534 (1972).

33. MALAISSE W.J., HAGER D.L. and L. ORCI : The stimulus-secretion coupling of glucose-in-duced insulin release. IX. The participation of the beta cell web. Diabetes 21, suppl. 2, 594-604 (1972).

34. RUFENER C., ROUILLER Ch. and L. ORCI : Effect of vincristine on the ultrastructure of rat neurohypophysis. Experientia 28, 837-838 (1972).

35. ORCI L., PERRELET A. and A.A. LIKE : Fenestrae in the rough endoplasmic reticulum of the exocrine pancreatic cells. J. Cell Biol. 55, 245-249 (1972).

36. CAMERON D.P., STAUFFACHER W., ORCI L., AMHERDT M. and A.E. RENOLD : Defective immunoreactive insulin secretion in the Acomys cahirinus. Diabetes 21, 1060-1071 (1972).

37. ORCI L., AMHERDT M., MALAISSE-LAGAE F., ROUILLER Ch. and A.E. RENOLD : In-sulin release by emiocytosis : demonstration with freeze-etching technique. Science 179, 82-84 (1973).

38. CAMERON D.P., STAUFFACHER W., AMHERDT M., ORCI L. and A.E. RENOLD : Kinetics of immunoreactive release in obese hyperglycemic laboratory rodents. Endocrinology 92, 257-264 (1973).

39. MARLISS E.B., WOLLHEIM C.B., BLONDEL B., ORCI L., LAMBERT A.E., STAUFFACHER W., LIKE A.A. and A.E. RENOLD : Insulin and glucagon release from monolayer cell cultures of pancreas from new-born rats. Eur. J. Clin. Invest. 3, 16-26 (1973).

40. ORCI L., AMHERDT M., HENQUIN J.C., LAMBERT A.E., UNGER R.H. and A.E. RE-NOLD : Pronase effect on pancreatic beta-cell secretion and morphology. Science 180, 647-649 (1973).

41. VAN OBBERGHEN E., SOMERS G., DEVIS G. VAUGHAN G.D., MALAISSE-LAGAE F., ORCI L. and W.J. MALAISSE : Dynamics of insulin release and micro-tubular-microfilamentous system. I. Effect of cytochalasin B. J. Clin. Invest 52, 1041-1051 (1973).

42. MARLISS E.B., GIRARDIER L., SEYDOUX J., WOLLHEIM C.B., KANAZAWA Y., ORCI L., RENOLD A.E. and D. PORTE Jr. : Glucagon release induced by pancreatic nerve stimulation in the dog. J. Clin. Invest. 52, 1246-1259 (1973).

43. ORCI L., LIKE A.A., AMHERDT M., BLONDEL B., KANAZAWA Y., MARLISS E.B., LAMBERT A.E., WOLLHEIM C.B. and A.E. RENOLD : Monolayer cell culture of neonatal rat pancreas : an ultrastructural and biochemical study of functioning endocrine cells. J. Ultrastr. Res. 43, 270-297 (1973).

44. ORCI L., LE MARCHAND Y., SINGH A., ASSIMACOPOULOS-JEANNET F., ROUILLER Ch. and B. JEANRENAUD : Role of microtubules in lipoprotein secretion by the liver. Nature 244, 30-32 (1973).


45. ORCI L., MALAISSE-LAGAE F., RAVAZZOLA M., AMHERDT M. and A.E. RENOLD : Exocytosis-endocytosis coupling in the pancreatic beta-cell. Science 181, 561-562 (1973).

46. ORCI L., UNGER R.H. and A.E. RENOLD : Structural coupling between pancreatic islet cells. Experientia 29, 1015-1018 (1973).

47. ORCI L. and A. PERRELET : Membrane-associated particles : increase at sites of pinocytosis demonstrated by freeze-etching. Science 181, 868-869 (1973).

48. LE MARCHAND Y., SINGH A., ASSIMACOPOULOS-JEANNET F., ORCI L., ROUILLER Ch. and B. JEANRENAUD : A role for the microtubular system in the release of very low density lipoproteins by perfused mouse livers. J. Biol. Chem. 248, 6862-6870 (1973).

49. ORCI L., PERRELET A., RAVAZZOLA M., MALAISSE-LAGAE F. and A.E. RENOLD : A specialized membrane junction between nerve endings and B-cells in islets of Langerhans. Eur. J. Clin. Invest. 3, 443-445 (1973).

50. AMMON H.P.T., ORCI L. and J. STEINKE : Effect of chlorpromazine (CPZ) on insulin release in vivo and in vitro in the rat. J. Pharmacol. Exper. Therap. 187, 423-429 (1973).

51. ORCI L., PERRELET A. and Y. DUNANT : A Peculiar substructure in the postsynaptic mem-brane of Torpedo Electroplax. Proc. Natl. Acad. Sci. USA 71, 307-310 (1974).

52. DEVIS G., VAN OBBERGHEN E., SOMERS G., MALAISSE-LAGAE F., ORCI L. and W.J. MALAISSE : Dynamics of insulin release and microtubular-microfilamentous system. II. Effect of vincristine. Diabetologia 10, 53-59 (1974).

53. PRICAM C., HUMBERT F., PERRELET A. and L. ORCI : A freeze-etch study of the tight junc-tions of the rat kidney tubules. Lab. Invest. 30, 286-291 (1974).

54. ORCI L. : A portrait of the pancreatic B-cell. Diabetologia 10, 163-187 (1974).

55. NORDMANN J.J., DREIFUSS J.J., BAKER P.F., RAVAZZOLA M., MALAISSE-LAGAE F. and L. ORCI : Secretion dependent uptake of extracellular fluid by the rat neurohypophysis. Nature 250, 155-157 (1974).

56. AMHERDT M., HARRIS V., RENOLD A.E., ORCI L. and R.H. UNGER : Hepatic autophagy in uncontrolled experimental diabetes and its relationships to insulin and glucagon. J. Clin. Invest. 54, 188-193 (1974).

57. SCHOFIELD J.G., MIRA-MOSER F., SCHORDERET M. and L. ORCI : Somatostatin inhibition of rat growth hormone release in vitro in the presence of BaC12 or 3-isobutyl-1-methylxanthine. FEBS Letters 46, 171-174 (1974).

58. PRICAM C., HUMBERT F., PERRELET A. and L. ORCI : Gap junction in mesangial and lacis cells. J. Cell Biol. 63, 349-354 (1974).

59. ORCI L., AMHERDT M., MALAISSE-LAGAE F., PERRELET A., DULIN W.E., GERRIT-SEN G.C., MALAISSE W.J. and A.E. RENOLD : Morphological characterization of membrane systems in A- and B-cells of the Chinese hamster. Diabetologia 10, 529-539 (1974).

60. LAMBERT A.E., HENQUIN J.C., ORCI L. and A.E. RENOLD : Enzyme-induced modifications of beta cell function. I. Effect of pronase on insulin secretion. Eur. J. Clin. Invest. 4, 459-468 (1974).


61.VAN OBBERGHEN E., SOMERS G., DEVIS G., RAVAZZOLA M., MALAISSE-LAGAE F., ORCI L. and W.J. MALAISSE : Dynamics of insulin release and microtubular-microfilamentous system. VI. Effect of D20. Endocrinology 95, 1518-1528 (1974).

62. GABBIANI G., MALAISSE-LAGAE F., BLONDEL B. and L. ORCI : Actin in pancreatic islet cells. Endocrinology 95, 1630-1635 (1974).

63. UNGER R.H. and L. ORCI : The essential role of glucagon in the pathogenesis of diabetes mel-litus. The Lancet no 7897, vol. I, 14-16 (1975).

64. DOBBS R., SAKURAI H., SASAKI H., FALOONA G., VALVERDE I., BAETENS D., ORCI L. and R.H. UNGER : Glucagon : Role in the hyperglycemia of diabetes mellitus. Science 187, 544-547 (1975).

65. MALAISSE-LAGAE F., RAVAZZOLA M., AMHERDT M., GUTZEIT A., STAUFFACHER W., MALAISSE W.J. and L. ORCI : An apparent abnormality of the B-cell in spiny mice (Acomys cahirinus). Diabetologia 11, 71-76 (1975).

66. SCHOFIELD J.G. and L. ORCI : Release of growth hormone from ox pituitary slices after pro-nase treatment. J. Cell Biol. 65, 223-227 (1975).

67. SASAKI H., RUBALCAVA R., BAETENS D., BLAZQUEZ E., SRIKANT C.B., ORCI L. and R.H. UNGER : Identification of glucagon in the gastro-intestinal tract. J. Clin. Invest. 56, 135-145 (1975).

68. SHARP G.W., WOLLHEIM C., MULLER W.A., GUTZEIT A., TRUEHEART P.A., BLONDEL B., ORCI L. and A.E. RENOLD : Studies on the mechanism of insulin release. Fed. Proc. 34, 1537-1548 (1975).

69. HUMBERT F., PRICAM C., PERRELET A. and L. ORCI : Specific plasma membrane differ-entiations in the cells of the kidney collecting tubule. J. Ultrastr. Res. 52, 13-20 (1975).

70. ORCI L., RUFENER C., MALAISSE-LAGAE F., BLONDEL B., AMHERDT M., BATAILLE D., FREYCHET P. and A. PERRELET : A morphological approach to surface receptors in islet and liver cells. Israël J. Med. Sc. 11, 639-655 (1975).

71. MIRA-MOSER F., SCHOFIELD J.G. and L. ORCI : Tight junction between follicular cells of the anterior pituitary gland : a freeze-fracture study. J. Microsc. Biol. Cell 22, 117-120 (1975).

72. RUFENER C., DUBOIS M.P., MALAISSE-LAGAE F. and L. ORCI : Immuno-fluorescent re-activity to antisomatostatin in the gastro-intestinal mucosa of the dog. Diabetologia 11, 321-324 (1975).

73. PATZELT Ch., SINGH A., LE MARCHAND Y., ORCI L. and B. JEANRENAUD: Colchicine binding protein of the liver : its characterization and relation to microtubules. J. Cell Biol. 66, 609-620 (1975).

74. ORCI L., BAETENS D., DUBOIS M.P. and C. RUFENER : Evidence for the D-cell of the pancreas secreting somatostatin. Horm. Metab. Res. 7, 400-402 (1975).

75. PRICAM C., HUMBERT F., PERRELET A., AMHERDT M. and L. ORCI : Intercellular junc-tions in podocytes of nephrotic glomerulus as seen with freeze-fracture. Lab. Invest. 33, 209-219 (1975).

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RELET A. and R.H. UNGER : A morphological basis for intercellular communication between A- and B-cells in the endocrine pancreas. J. Clin. Invest. 56, 1066-1070 (1975).

77. VAN OBBERGHEN E., SOMERS G., DEVIS G., RAVAZZOLA M., MALAISSE-LAGAE F., ORCI L. and W.J. MALAISSE : Dynamics of insulin release and microtubular-microfilamentous system. VII. Do microfilaments provide the motive force for the translocation and extrusion of beta-granules ? Diabetes 24, 892-901 (1975).

78. HUMBERT F., PRICAM C., PERRELET A. and L. ORCI : Freeze-fracture differences between plasma membranes of descending and ascending branches of the rat Henle’s thin loop. Lab. Invest. 33, 407-411 (1975).

79. MALAISSE-LAGAE F., RAVAZZOLA M., ROBBERECHT P., VANDERMEERS A., MA-LAISSE W.J. and L. ORCI : Evidence for topographic partition of secretory function. Science 190, 795-797 (1975).

80. MONTESANO R., FRIEND D.S., PERRELET A. and L. ORCI : In vivo assembly of tight junc-tions in fetal rat liver. J. Cell Biol. 67, 310-319 (1975).

81. ORCI L., MALAISSE-LAGAE F., AMHERDT M., RAVAZZOLA M., WEISSWANGER A., DOBBS R., PERRELET A. and R. UNGER: Cell contacts in human islets of Langerhans. J. Clin. Endocrinol. Metab. 41, 841-844 (1975).

82. SINGH A., LE MARCHAND Y., ORCI L. and B. JEANRENAUD : Colchicine administration to mice : a metabolic and ultrastructural study. Eur. J. Clin. Invest. 5, 495-505 (1975)

83. RUFENER C., AMHERDT M., DUBOIS M.P. and L. ORCI : Ultrastructural immunocytochemi-cal localization of somatostatin in D-cells of rat pancreatic monolayer culture. J. Histochem. Cytochem. 23, 866-869 (1975).

84. ORCI L. and R.H. UNGER : Functional subdivision of islets of Langerhans and possible role of D-cells. The Lancet II, 1243-1244 (1975).

85. ORCI L., HUMBERT F., AMHERDT M., GROSSO A., DE SOUSA R.C. and A. PERRELET : Patterns of membrane organization in toad bladder epithelium : A freeze-fracture study. Experi-entia 31, 1335-1338 (1975).

86. GABBIANI G., MONTESANO R., TUCHWEBER B., SALAS M. and L. ORCI : Phalloidin-induced hyperplasia of actin filaments in rat hepatocytes. Lab. Invest. 33, 562-569 (1975).

87. ORCI L., BAETENS D., RUFENER C., AMHERDT M., RAVAZZOLA M., STUDER P., MALAISSE-LAGAE F. et R.H. UNGER : Réactivité de la cellule à somatostatine de l’îlot de Langerhans dans le diabète expérimental. C.R. Acad. Sci. Paris, D, 281, 1883-1885 (1975).

88. BAETENS D., RUFENER C., UNGER R.H., RENOLD A.E. et L. ORCI : Identification par immunocytochimie de la cellule sécrétant le glucagon dans la muqueuse gastrique. C.R. Acad. Sci. D, 282, 195-197 (1976).

89. MIRA-MOSER F., SCHOFIELD J.G. and L. ORCI : Modifications in the release of rat growth hormone in vitro and the morphology of rat anterior pituitaries incubated in various ionophores. Eur. J. Clin. Invest. 6, 103-111 (1976).


90. MORRISON A.D., BERWICK L., ORCI L. and A. WINEGRAD : Morphology and metabolism of an aortic intima-media preparation in which an intact endothelium is preserved. J. Clin. Invest. 57, 650-660 (1976).

91. MONTESANO R., GABBIANI G., PERRELET A. and L. ORCI : In vivo induction of tight junction proliferation in rat liver. J. Cell Biol. 68, 793-798 (1976).

92. HUMBERT F., GRANDCHAMP A., PRICAM C., PERRELET A. and L. ORCI : Morphological changes in tight junctions of Necturus maculosus proximal tubules undergoing saline diuresis. J. Cell Biol. 69, 90-96 (1976).

93. BLAZQUEZ E., RUBALCAVA S., MONTESANO R., ORCI L. and R. UNGER : Development of insulin and glucagon binding and the adenylate cyclase response in liver membranes of the prenatal, postnatal, and adult rat : Evidence of glucagon “resistance”. Endocrinology 98, 1014-1023 (1976).

94. BAETENS D., RUFENER C., SRIKANT B.C., DOBBS R., UNGER R. and L. ORCI : Identi-fication of glucagon-producing cells (A-cells) in dog gastric mucosa. J. Cell Biol. 69, 455-464 (1976).

95. MULLER P., SINGH A., ORCI L. and B. JEANRENAUD : Secretory processes carbohydrate and lipid metabolism in isolated mouse hepatocytes. Aspects of regulation by glucagon and insulin. Bioch. Bioph. Acta. 428, 480-494 (1976).

96. RAVAZZOLA M., MALAISSE-LAGAE F., AMHERDT M., PERRELET A., MALAISSE W.J. and L. ORCI : Patterns of calcium localization in pancreatic endocrine cells. J. Cell Sci. 27, 107-117 (1976).

97. ORCI L., BAETENS D., RUFENER C., AMHERDT M., STUDER P., MALAISSE-LAGAE F. and R.H. UNGER : Hypertrophy and hyperplasia of somatostatin-containing D-cells in diabetes. Proc. Natl. Acad. Sci. 73, 1338-1342 (1976).

98. RUFENER C., AMHERDT M., BAETENS D., YANAIHARA N. and L. ORCI : Immunofluo-rescent localization of secretin in pancreatic monolayer culture. Histochemistry 47, 171-173 (1976).

99. ORCI L., AMHERDT M., MALAISSE-LAGAE F., RAVAZZOLA M., MALAISSE W.J., PER-RELET A. and A.E. RENOLD : Islet cell membrane alteration by diabetogenic drugs. Lab. Invest. 34, 451-454 (1976).

100. RUFENER C., BAETENS D. and L. ORCI : Localization of bovine pancreatic polypeptide (BPP)-like immunoreactivity in rat pancreatic monolayer culture. Experientia 32, 919-920 (1976).

101. THEODOSIS D.T., DREIFUSS J.J., HARRIS M.C. and L. ORCI : Secretion related uptake of horseradish peroxidase in neurohypophysal axons. J. Cell Biol. 70, 294-303 (1976).

102. CARPENTIER J.-L., PERRELET A. and L. ORCI : Effects of insulin, glucagon and epinephrine on the plasma membrane of the white adipose cell : a freeze-fracture study. Lipid Res. 17, 335-342 (1976).

103. ORCI L., BAETENS D., RUFENER C., BROWN M., VALE W. and R. GUILLEMIN : Evidence for immunoreactive neurotensin in dog intestinal mucosa. Life Science 19, 559-562 (1976).

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and rat kidney : a freeze-fracture study. J. Ultrastr. Res. 56, 202-214 (1976).

105. BAGGIOLINI M., AMHERDT M. and L. ORCI : Unusual membrane fracture faces in poly-morphonuclear leukocyte granules. Experientia 32, 1400-1401 (1976).

106. ORCI L., BAETENS D., RAVAZZOLA M., STEFAN Y. and F. MALAISSE-LAGAE : Ilots à polypeptide pancréatique (PP) et îlots à glucagon : distribution topographique distincte dans le pancréas de rat. C.R. Acad. Sci. Paris 283, 1213-1216 (1976).

107. BLAZQUEZ E., MUNOZ-BARRAGAN L., PATTON G.S., ORCI L., DOBBS R.E. and R.H. UNGER : Gastric A-cell function in insulin-deprived depancreatized dogs. Endocrinology 99, 1182-1188 (1976).

108. PATEL Y.C., ORCI L., BANKIER A. and D.P. CAMERON : Decreased pancreatic somatostatin (SRIF) concentration in spontaneously diabetic mice. Endocrinology 99, 1415-1418 (1976).

109. ORCI L. : The microanatomy of the islets of Langerhans. Metabolism 25, suppl. 1, 1303-1313 (1976).

110. CARPENTIER J.-L., PERRELET A. et L. ORCI : Modification ultrastructurale de l’organisation des membranes plasmiques des adipocytes chez les souris obèse (ob/ob). C.R. Acad. Sci. Paris 283, 1417-1419 (1976).

111. ORCI L., PERRELET A., MALAISSE-LAGAE F. et P. VASSALLI : Evidence pour l’existence de pores dans les particules intramembranaires révélées en cryodécapage. C.R. Acad. Sci. Paris 283, 1509-1510 (1976).

112. MOODY A.J., FRANDSEN E.K., JACOBSEN H., SUNDBY F. and L. ORCI : The structural and immunologic relationship between gut GLIs and glucagon. Metabolism 25, suppl. 1, 1336-1338 (1976).

113. PATTON G.S., DOBBS R., ORCI L., VALE W. and R.H. UNGER : Stimulation of pancreatic im-munoreactive somatostatin (IRS) release by glucagon. Metabolism 25, suppl. 1, 1499 (1976).

114. ORCI L., BAETENS D., RAVAZZOLA M., STEFAN Y. and F. MALAISSE-LAGAE : Pancre-atic polypeptide and glucagon : non-random distribution in pancreatic islets. Life Sciences 19, 1811-1816 (1976).

115. PATTON G.S., IPP E., DOBBS R.E., ORCI L., VALE W. and R.H. UNGER : Response of pan-creatic immunoreactive somatostatin to arginine. Life Sciences 19, 1957-1960 (1976).

116. CARPENTIER J.-L., PERRELET A. and L. ORCI : Morphological changes of the adipose cell plasma membrane during lipolysis. J. Cell Biol. 72, 104-117 (1977).

117. UNGER R.H. and L. ORCI : Possible roles of the pancreatic D-cell in the normal and diabetic states. Diabetes 26, 241-244 (1977).

118. RAVAZZOLA M. and L. ORCI : Intercellular junctions in the rat parathyroid gland : a freeze-fracture study. Biol. Cellulaire 28, 137-144 (1977).

119. MORRISON A.D., ORCI L., BERWICK L., PERRELET A. and A.I. WINEGRAD : The ef-fects of anoxia on the morphology and composite metabolism of the intact aortic intima-media preparation. J. Clin. Invest. 59, 1027-1037 (1977).


120. ORCI L., PERRELET A., MALAISSE-LAGAE F. and P. VASSALLI : Pore-like structures in biological membranes. J. Cell Science 25, 157-161 (1977).

121. PATTON G.S., IPP E., DOBBS R.E., ORCI L., VALE W. and R.H. UNGER : Pancreatic im-munoreactive somatostatin release. Proc. Natl. Acad. Sci. 74, 2140-2143 (1977).

122. MALAISSE-LAGAE F., CARPENTIER J.-L., PATEL Y.C., MALAISSE W.J. and L. ORCI : Pancreatic polypeptide : a possible role in the regulation of food intake in the mouse. Hypothesis. Experientia 33, 915-916 (1977).

123. UNGER R.H., IPP E., SCHUSDZIARRA V. and L. ORCI : Hypothesis : Physiologic role of pancreatic somatostatin and the contribution of D-cell disorders to diabetes mellitus. Life Science 20, 2081-2086 (1977).

124. HUMBERT F., ABRAMOW M., PERRELET A. and L. ORCI : Feasibility of freeze-fracturing single isolated renal tubules. Kidney Intern. 12, 66-71 (1977).

125. FRIEND D.S., ORCI L., PERRELET A. and Y. YANAGIMACHI : Membrane particle changes attending the acrosome reaction in Guinea pig spermatozoa. J. Cell Biol. 74, 561-577 (1977).

126. ORCI L., PERRELET A. and D.S. FRIEND : Freeze-fracture of membrane fusions during exo-cytosis in pancreatic B-cells. J. Cell Biol. 75, 23-30 (1977).

127. HUMBERT F., MONTESANO R., GROSSO A., DE SOUSA R.C. and L. ORCI: Particle ag-gregates in plasma and intracellular membranes of toad bladder (granular cell). Experientia 33, 1364-1367 (1977).

128. FRIGERIO B., RAVAZZOLA M., ITO S., BUFFA R., CAPELLA C., SOLCIA E. and L. ORCI : Histochemical and ultrastructural identification of neurotensin cells in the dog ileum. Histo-chemistry 54, 123-131 (1977).

129. CARPENTIER J.-L., PERRELET A. and L. ORCI : Perturbation of the adipose cell plasma membrane in obese (ob/ob) mice. Lab. Invest. 37, 260-264 (1977).

130. CARPENTIER J.-L., MALAISSE-LAGAE F., MULLER W. and L. ORCI : Glucagon release from rat pancreatic islets : A combined morphological and functional approach. J. Clin. Invest. 60, 1174-1182 (1977).

131. PATEL Y.C., CAMERON D.P., STEFAN Y., MALAISSE-LAGAE F. and L. ORCI : Somatosta-tin : Widespread abnormality in tissues of spontaneously diabetic mice. Science 198, 930-931 (1977).

132. HABENER J.F., STEVENS T.D., RAVAZZOLA M., ORCI L. and J.T. POTTS, Jr. : Effects of calcium ionophores on the synthesis and release of parathyroid hormone. Endocrinology 101, 1524-1537 (1977).

133. RAVAZZOLA M., BAETENS D., ENGERMAN R., KOVACEVIC N., VRANIC M. and L. ORCI : Endocrine cells in oxyntic mucosa of a dog 5 years after pancreatectomy. Horm. Metab. Res. 9, 480-483 (1977).

134. HABENER J.F., AMHERDT M. and L. ORCI : Subcellular organelles involved in the conver-sion of biosynthetic precursors of parathyroid hormone. Trans. Assoc. Amer. Phys. xc, 366-379 (1977).


135. THEODOSIS D.T., DREIFUSS J.J. and L. ORCI : Two classes of microvesicles in the neuro-hypophysis. Brain Research 123, 159-169 (1977).

136. BAETENS D., STEFAN Y., RAVAZZOLA M., MALAISSE-LAGAE F., COLEMAN D.L. and L. ORCI : Alteration of islet cell populations in spontaneously diabetic mice. Diabetes 27, 1-7 (1978).

137. BORDI C., TOGNI R., BAETENS D., RAVAZZOLA M., MALAISSE-LAGAE F. and L. ORCI : Human islet cell tumor storing pancreatic polypeptide : A light and electron microscopic study. J. Clin. Endocr. & Metab. 46, 215-219 (1978).

138. CARPENTIER J.-L., GORDEN P., AMHERDT M., VAN OBBERGHEN E., KAHN C.R. and L. ORCI : 125I-insulin binding to cultured human lymphocytes. Initial localization and fate of hormone determined by quantitative electron microscopic autoradiography. J. Clin. Invest. 61, 1057-1070 (1978).

139. ORCI L., CARPENTIER J.-L., PERRELET A., ANDERSON R.G.W., GOLDSTEIN J.L. and M.S. BROWN : Occurrence of low density lipoprotein receptors within large pits on the surface of human fibroblasts as demonstrated by freeze-etching. Exp. Cell Res. 113, 1-13 (1978).

140. GORDEN P., CARPENTIER J.-L., FREYCHET P., LE CAM A. and L. ORCI : Intracellular translocation of iodine-125-labeled insulin : direct demonstration in isolated hepatocytes. Science 200, 782-785 (1978).

141. GORDEN P., CARPENTIER J.-L., COHEN S. et L. ORCI : Interaction du facteur de croissance épidermique avec des fibroblastes humains en culture : Une étude autoradiographique à l’échelon ultrastructural. C.R. Acad. Sci. 286, 1471-1474 (1978).

142. FUKUMA M., CARPENTIER J.-L., ORCI L., GREENE D.A. and A.I. WINEGRAD : An altera-tion in internodal myelin membrane structure in large sciatic nerve fibres in rats with acute strep-tozotocin diabetes and impaired nerve conduction velocity. Diabetologia 15, 65-72 (1978).

143. THEODOSIS D.T., DREIFUSS J.J. and L. ORCI : A freeze-fracture study of membrane events during neurohypophysial secretion. J. Cell Biol. 78, 542-553 (1978).

144. RAVAZZOLA M., ORCI L., HABENER J.F. and J.T. POTTS, Jr. : Parathyroid secretory protein : Immunocytochemical localisation within cells that contain parathyroid hormone. The Lancet II, 371-372 (1978).

145. PATEL Y.C., CAMERON D.P., BANKIER A., MALAISSE-LAGAE F., RAVAZZOLA M., STUDER P. and L. ORCI : Changes in somatostatin concentration in pancreas and other tissues of streptozotocin diabetic rats. Endocrinology 103, 917-923 (1978).

146. SCHUSDZIARRA V., IPP E., HARRIS V., DOBBS R.E., RASKIN P., ORCI L. and R.H. UN-GER : Studies of the physiology and pathophysiology of the pancreatic D cell. Metabolism 27, 1227-1232 (1978).

147. STEFAN Y., MALAISSE-LAGAE F., YOON J.W., NOTKINS A.L. and L. ORCI: Virus-induced diabetes in mice : A quantitative evaluation of islet cell population by immunofluorescence tech-nique. Diabetologia 15, 395-401 (1978).

148. MONTESANO R., MIRA-MOSER F., STEFAN Y., PERRELET A. and L. ORCI: Tight junc-tions in fetal rat liver explants grown in vitro. J. Ultrastr. Res. 64, 182-190 (1978).

Lelio ORCI Publications - Page 11 -149. AMHERDT M., BAGGIOLINI M., PERRELET A. and L. ORCI : Freeze-fracture of membrane

fusions in phagocytosing polymorphonuclear leukocytes. Lab. Invest. 39, 398-404 (1978).

150. GORDEN P., CARPENTIER J.-L., COHEN S. and L. ORCI : Epidermal growth factor : morpho-logical demonstration of binding, internalization and lysosomal association in human fibroblasts. Proc. Natl. Acad. Sci. USA 75, 5025-5029 (1978).

151. BROWN D., ILIC V. and L. ORCI : Rod-shaped particles in the plasma membrane of the mito-chondria-rich cell of amphibian epidermis. Anat. Rec. 192, 269-276 (1978).

152. ROTH J., BENDAYAN M. and L. ORCI : Ultrastructural localization of intracellular antigens by the use of protein A-gold complex. J. Histochem. Cytochem. 26, 1074-1081 (1978).

153. SOMERS G., BLONDEL B., ORCI L. and W.J. MALAISSE : Motile events in pancreatic en-docrine cells. Endocrinology 104, 255-264 (1979).

154. ORCI L., AMHERDT M., ROTH J. and A. PERRELET : Inhomogeneity of surface labelling of B-cells at prospective sites of exocytosis. Diabetologia 16, 135-138 (1979).

155. HABENER J.F., AMHERDT M., RAVAZZOLA M. and L. ORCI : Parathyroid hormone biosyn-thesis. Correlation of conversion of biosynthetic precursors with intracellular protein migration as determined by electron microscope autoradiography. J. Cell Biol. 80, 715-731 (1979).

156. PATEL Y.C., AMHERDT M. and L. ORCI : Somatostatin secretion from monolayer cultures of neonatal rat pancreas. Endocrinology 104, 676-679 (1979).

157. CARPENTIER J.-L., GORDEN P., FREYCHET P., LE CAM A. and L. ORCI : Lysosomal as-sociation of 125I-insulin in isolated rat hepatocytes. Direct demonstration by quantitative electron microscopic autoradiography. J. Clin. Invest. 63, 1249-1261 (1979).

158. MALAISSE-LAGAE F., AMHERDT M., RAVAZZOLA M., SENER A., HUTTON J.C., ORCI L. and W.J. MALAISSE : Role of microtubules in the synthesis, conversion, and release of (pro)insulin. A biochemical and radioautographic study in rat islets. J. Clin. Invest. 63, 1284-1296 (1979).

159. CARPENTIER J.-L., GORDEN P., GOLDSTEIN J.L., ANDERSON R.G.W., BROWN M.S. and L. ORCI : Binding and internalization of 125I-LDL in normal and mutant human fibroblasts : A quantitative autoradiographic study. Experimental Cell Research 121, 135-142 (1979).

160. CARPENTIER J.-L., GORDEN P., BARAZZONE P., FREYCHET P., LE CAM A. and L. ORCI : Intracellular localization of 125I-insulin in hepatocytes from intact rat liver. Proc. Natl. Acad. Sci. 76, 2803-2807 (1979).

161. RAVAZZOLA M., SIPERSTEIN A., MOODY A.J., SUNDBY F., JACOBSEN H. and L. ORCI : Glicentin immunoreactive cells : their relationship to glucagon-producing cells. Endocrinology 105, 499-508 (1979).

162. CONLON J.M., SAMSON W.K., DOBBS R.E., ORCI L. and R.H. UNGER : Glucagon-like polypeptides in canine brain. Diabetes 28, 700-702 (1979).

163. MORRISON A.D., ORCI L., PERRELET A. and A.I. WINEGRAD : Studies of the effects of an elevated glucose concentration on the ultrastructure and composite metabolism of the intact rabbit aortic intima-media preparation. Diabetes 28, 720-723 (1979).


164. MEDA P., PERRELET A. and L. ORCI : Increase of gap junctions between pancreatic B-cells during stimulation of insulin secretion. J. Cell Biol. 82, 441-448 (1979).

165. RAVAZZOLA M., SIPERSTEIN A., MOODY A.J., SUNDBY F., JACOBSEN H. and L. ORCI : Glicentin : A precursor of glucagon ? Life Sciences 25, 287-290 (1979).

166. KREJS G.J., ORCI L., CONLON J.M., RAVAZZOLA M., DAVIS G.R., RASKIN P., COLLINS S.M., McCARTHY D.M., BAETENS D., RUBENSTEIN A., ALDOR T.A.M. and R.H. UNGER : Somatostatinoma syndrome. Biochemical, morphologic and clinical features. New Engl. J. Med. 301, 285-292 (1979).

167. CARPENTIER J.-L., GORDEN P., FREYCHET P., LE CAM A. and L. ORCI : 125I-insulin is preferentially internalized in regions of the hepatocytes rich in lysosomal and Golgi structures. Experientia 35, 904-905 (1979).

168. GREENE D.A., WINEGRAD A.I., CARPENTIER J.-L., BROWN M.J., FUKUMA M. and L. ORCI : Rabbit sciatic nerve fascicle and “endoneurial” preparations for in vitro studies of pe-ripheral nerve glucose metabolism. J. Neurochem. 33, 1007-1018 (1979).

169. BORDI C., RAVAZZOLA M., BAETENS D., GORDEN P., UNGER R.H. and L. ORCI : A study of glucagonomas by light and electron microscopy and immunofluorescence. Diabetes 28, 925-936 (1979).

170. RAVAZZOLA M., BROWN D., LEPPALUOTO J. and L. ORCI : Localization by immunores-cence of thyrotropin-releasing hormone in the cutaneous glands of the frog, Rana ridibunda. Life Sciences 25, 1331-1334 (1979).

171. BAETENS D., MALAISSE-LAGAE F., PERRELET A. and L. ORCI : Endocrine pancreas : Three-dimensional reconstruction shows two types of islets of Langerhans. Science 206, 1323-1325 (1979).

172. GORDEN P., CARPENTIER J.-L., VAN OBBERGHEN E., BARAZZONE P., ROTH J. and L. ORCI : Insulin-induced receptor loss in the cultured human lymphocyte : Quantitative morpho-logical perturbations in the cell and plasma membrane. J. Cell Sci. 39, 77-88 (1979).

173. MALAISSE-LAGAE F., STEFAN Y., COX J., PERRELET A. and L. ORCI : Identification of a lobe in the adult human pancreas rich in pancreatic polypeptide. Diabetologia 17, 361-365 (1979).

174. CARPENTIER J.-L., GORDEN P., FREYCHET P., LE CAM A. and L. ORCI : Relationship of binding to internalization of 125I-insulin in isolated rat hepatocytes. Diabetologia 17, 379-384 (1979).

175. MONTESANO R., PERRELET A., VASSALLI P. and L. ORCI : Absence of filipin-sterol com-plexes from large coated pits on the surface of culture cells. Proc. Natl. Acad. Sci. 76, 6391-6395 (1979).

176. RAVAZZOLA M. et L. ORCI : Anatomie immunocytochimique des granules dans le pancréas endocrine humain. C.R. Acad. Sci. 289, 1161-1162 (1979).

177. BENDAYAN M., ROTH J., PERRELET A. and L. ORCI : Quantitative immunocytochemical localization of exocrine pancreatic enzymes in subcellular compartments of the rat acinar cell. J. Histochem. Cytochem. 28, 149-160 (1980).


178. RAVAZZOLA M. and L. ORCI : Transformation of glicentin-containing L-cells into glucagon-containing cells by enzymatic digestion. Diabetes 29, 156-158 (1980).

179. RAVAZZOLA M. and L. ORCI : Glucagon and glicentin immuno-reactivity are topologically segregated in the α granule of the human pancreatic A-cell. Nature 284, 66-67 (1980).

180. MEDA P., DENEF J.F., PERRELET A. and L. ORCI : Nonrandom distribution of gap junctions between pancreatic β-cells. Am. J. Physiol. 238, 114-119 (1980).

181. TRIMBLE E.R., KARAKASH C., MALAISSE-LAGAE F., VASSUTINE I., ORCI L. and A.E. RENOLD : Effects of intraportal islet transplantation on the transplanted tissue and the recipient pancreas. I. Functional Studies. Diabetes 29, 341-347 (1980).

182. RAVAZZOLA M. and L. ORCI : A pancreatic polypeptide (PP)-like immunoreactant is present in the glicentin-containing cell of the cat intestine. Histochemistry 67, 221-224 (1980).

183. MEDA P., HOOGHE-PETERS E. and L. ORCI : Monolayer cultures of adult pancreatic islet cells on osmotically disrupted fibroblasts. Diabetes 29, 497-500 (1980).

184. ABRAMOW M. and L. ORCI : On the “tightness” of the rabbit descending limb of the loop of Henle - Physiological and Morphological evidence. Int. J. Biochem. 12, 23-27 (1980).

185. BARAZZONE P., CARPENTIER J.-L., GORDEN P., VAN OBBERGHEN E. and L. ORCI : Polar redistribution of 125I-labeled insulin on the plasma membrane of cultures human lymphocytes. Nature 286, 401-403 (1980).

186. SCHNEIDER-PICARD G., CARPENTIER J.-L. and L. ORCI : Quantitative evaluation of gap junctions during development of the brown adipose tissue. J. Lipid Research 21, 600-607 (1980).

187. PATEL Y.C., WHEATLEY T., MALAISSE-LAGAE F. and L. ORCI : Elevated portal and pe-ripheral blood concentration of immunoreactive somatostatin in spontaneously diabetic (BBL) Wistar rats. Suppression with insulin. Diabetes 29, 757-761 (1980).

188. ORCI L., MONTESANO R. and D. BROWN : Heterogeneity of toad bladder granular cell lu-minal membranes : Distribution of filipin-sterol complexes in freeze-fracture. Biochim. Biophys. Acta 601, 443-452 (1980).

189. MEDA P., HALBAN P., PERRELET A., RENOLD A.E. and L. ORCI : Gap junction develop-ment is correlated with insulin content in pancreatic B-cell. Science 209, 1026-1028 (1980).

190. BARAZZONE P., LESNIAK M.A., GORDEN P., VAN OBBERGHEN E., CARPENTIER J.-L. and L. ORCI : Binding, internalization, and lysosomal association of 125I-human growth hormone in cultured human lymphocytes : A quantitative morphologic and biochemical study. J. Cell Biol. 87, 360-369 (1980).

191. BARAZZONE P., GORDEN P., CARPENTIER J.-L., FREYCHET P., CANIVET B. and L. ORCI : Binding, internalization and lysosomal association of 125I-glucagon in isolated rat hepa-tocytes. A quantitative electron microscope autoradiographic study. J. Clin. Invest. 66, 1081-1093 (1980).

Lelio ORCI Publications - Page 14 -192. MONTESANO R., VASSALLI P., PERRELET A. and L. ORCI : Distribution of filipin-choles-

terol complexes at sites of exocytosis. A freeze-fracture study of degranulating mast cells. Cell Biol. Int. Rep. 4, 975-984 (1980).

193. ORCI L., MILLER R.G., MONTESANO R., PERRELET A., AMHERDT M. and P. VASSALLI : Opposite polarity of filipin-induced deformations in the membrane of condensing vacuoles and zymogen granules. Science 210, 1019-1021 (1980).

194. ORCI L. and W.J. MALAISSE : Hypothesis : Single and chain release of insulin secretory granules is related to anionic transport at exocytotic sites. Diabetes 29, 943-944 (1980).

195. ROTH J., RAVAZZOLA M., BENDAYAN M. and L. ORCI : Application of the protein A-gold technique for electron microscopic demonstration of polypeptide hormones. Endocrinology 108, 247-253 (1981).

196. ORCI L., MONTESANO R., MEDA P., MALAISSE-LAGAE F., BROWN D., PERRELET A. and P. VASSALLI : Heterogeneous distribution of filipin-cholesterol complexes across the cisternae of the Golgi apparatus. Proc. Natl. Acad. Sci. 78, 293-297 (1981).

197. BROWN D., MONTESANO R. and L. ORCI : Strech induces granule exocytosis in toad urinary bladder. Cell Biol. Int. Rep. 5, 275-285 (1981).

198. STEFAN Y., RAVAZZOLA M. and L. ORCI : Primitive islets contain two populations of cells with differing glucagon immunoreactivity. Diabetes 30, 192-195 (1981).

199. CARPENTIER J.-L., HALBAN P.A., RENOLD A.E. and L. ORCI : Internalization of 125I-in-sulin by IM-9 cultured human lymphocytes : A comparison between A14- monoiodo-pork and biosynthetic human insulin. Diabetes Care 4, 220-222 (1981).

200. HIZUKA N., GORDEN P., LESNIAK M.A., VAN OBBERGHEN E., CARPENTIER J.-L. and L. ORCI : Polypeptide hormone degradation and receptor regulation are coupled to ligand internalization. A direct biochemical and morphologic demonstration. J. Biol. Chem. 256, 4591-4597 (1981).

201. MEDA P., AMHERDT M., PERRELET A. and L. ORCI : Metabolic coupling between cultured pancreatic B-cells. Exp. Cell Res. 133, 421-430 (1981).

202. CARPENTIER J.-L., VAN OBBERGHEN E., GORDEN P., and L. ORCI : Binding, membrane redistribution, internalization and lysosomal association of 125I-anti-insulin receptor antibody in IM-9 cultured human lymphocyte : a comparison with 125I-insulin. Exp. Cell Res. 134, 81-92 (1981).

203. GALAN GALAN F., ROGERS R.M., GIRGIS S.I., ARNETT T.R., RAVAZZOLA M., ORCI L. and I. McINTYRE : Immunochemical characterization and distribution of calcitonin in the lizard. Acta Endocrinologica 97, 427-432 (1981).

204. HOOGHE-PETERS E.L., MEDA P., and L. ORCI : Co-culture of nerve cells and pancreatic islets. Developmental Brain Res. 1, 287-292 (1981).

205. RAVAZZOLA M., ORCI L., GIRGIS S.I., GALAN GALAN F. and I. McINTYRE : The lung is the major organ source of calcitonin in the lizard. Cell Biol. Int. Rep. 5, 937-944 (1981).

206. ROTH J., THORENS B., HUNZIKER W., NORMAN A.W. and L. ORCI : Vitamin D-depend-ent calcium binding protein : Immunocytochemical localization in chick kidney. Science 214, 197-200 (1981).


207. RAVAZZOLA M., PERRELET A., ROTH J. and L. ORCI : Insulin immunoreactive sites dem-onstrated in the Golgi apparatus of pancreatic B-cells. Proc. Natl. Acad. Sci. 78, 5661-5664 (1981).

208. ORCI L., SINGH A., AMHERDT M., BROWN D. and A. PERRELET : Microheterogeneity of protein and sterol content in kidney podocyte membrane. Nature 293, 646-647 (1981).

209. MONTESANO R., VASSALLI P. and L. ORCI : Structural heterogeneity of endocytic membranes in macrophages as revealed by the cholesterol probe, filipin. J. Cell Sci. 51, 95-107 (1981).

210. RAVAZZOLA M., UNGER R.H. and L. ORCI : Demonstration of glucagon in the stomach of human fetuses. Diabetes 30, 879-882 (1981).

211. CARPENTIER J.-L., GORDEN P., FREYCHET P., CANIVET B. and L. ORCI : The fate of [125I] iodoepidermal growth factor in isolated hepatocytes : A quantitative electron microscopic autoradiographic study. Endocrinology 109, 768-775 (1981).

212. CARPENTIER J.-L., VAN OBBERGHEN E., GORDEN P. and L. ORCI : Surface redistribution of 125I-insulin in cultured human lymphocytes. J. Cell Biol. 91, 17-25 (1981).

213. CANIVET B., GORDEN P., CARPENTIER J.-L., ORCI L. and P. FREYCHET : Glucagon degradation in isolated rat hepatocytes : Effect of ammonium chloride and chloroquine. Mol. & Cell Endocrinology 23, 311-320 (1981).

214. MEDA P., KOHEN E., KOHEN C., RABINOVITCH A. and L. ORCI : Direct communication of homologous and heterologous endocrine islet cells in culture. J. Cell Biol. 92, 221-226 (1982).

215. KAWAI K., ORCI L. and R.H. UNGER : High somatostatin uptake by the isolated perfused dog pancreas consistent with an “insulo-acinar” axis. Endocrinology 110, 660-662 (1982).

216. GARCIA-SEGURA L.-M., BAETENS D. and L. ORCI : Freeze-fracture cytochemistry of neu-ronal membranes : Inhomogeneous distribution of filipin-sterol complexes in perikarya, dendrites and axons. Brain Res. 234, 494-499 (1982).

217. MONTESANO R., ROTH J., ROBERT A. and L. ORCI : Non-coated membrane invaginations are involved in binding and internalization of cholera and tetanus toxins. Nature 296, 651-653 (1982).

218. BORDI C., RAVAZZOLA M., POLLAK A., LUBEC G. and L. ORCI : Neonatal islet cell ad-enoma : A distinct type of islet cell tumor ? Diabetes Care 5, 122-125 (1982).

219. FEHLMANN M., CARPENTIER J.-L., LE CAM A., THAMM P., SAUNDERS D., BRANDEN-BURG D., ORCI L. and P. FREYCHET : Biochemical and morphological evidence that the insulin receptor is internalized with insulin in hepatocytes. J. Cell Biol. 93, 82-87 (1982).

220. PERRELET A., GARCIA-SEGURA L.-M., SINGH A. and L. ORCI : Distribution of cytochemi-cally detectable cholesterol in the electric organ of Torpedo marmorata. Proc. Natl. Acad. Sci. USA 79, 2598-2602 (1982).

221. STEFAN Y., RAVAZZOLA M., GRASSO S., PERRELET A. and L. ORCI : Glicentin precedes glucagon in the developing human pancreas. Endocrinology 110, 2189-2191 (1982).

Lelio ORCI Publications - Page 16 -222. ROTH J., BONNER-WEIR S., NORMAN A.W. and L. ORCI : Immunocytochemistry of vita-

min D-dependent calcium binding protein in chick pancreas : Exclusive localization in B-cells. Endocrinology 110, 2216-2218 (1982).

223. ORCI L., BROWN D., AMHERDT M. and A. PERRELET : Distribution of intramembrane particles and filipin sterol complexes in plasma membranes of kidney. I. Corpuscule of Malpighi. Lab. Invest. 46, 545-553 (1982).

224. THORENS B., ROTH J., NORMAN A.W., PERRELET A. and L. ORCI : Immunocytochemical localization of the vitamin D-dependent calcium binding protein in chick duodenum. J. Cell Biol. 94, 115-122 (1982).

225. GORDEN P., CARPENTIER J.-L., MOULE M.L., YIP C.C. and L. ORCI : Direct demonstration of insulin receptor internalization : A quantitative electron microscopic study of covalently bound 125I-photoreactive insulin incubated with isolated hepatocytes. Diabetes 31, 659-661 (1982).

226. BROWN D., MONTESANO R. and L. ORCI : Patterns of filipin-sterol complex distribution in intact erythrocytes and intramembrane particle-aggregated ghost membranes. J. Histochem. Cytochem. 30, 702-706 (1982).

227. STEFAN Y., GRASSO S., PERRELET A. and L. ORCI : The pancreatic polypeptide-rich lobe of the human pancreas : Definitive identification of its derivation from the ventral pancreatic primordium. Diabetologia 23, 141-142 (1982).

228. ORCI L., BROWN D., ROTH J. and A.W. NORMAN : Vitamin D-dependent calcium bind-ing protein content is reduced in kidneys of juvenile-onset diabetics. The Lancet II, 102-103 (1982).

229. STEFAN Y., ORCI L., MALAISSE-LAGAE F., PERRELET A., PATEL Y. and R.H. UNGER : Quantitation of endocrine cell content in the pancreas of nondiabetic and diabetic humans. Dia-betes 31, 694-700 (1982).

230. BROWN D., ROTH J., KUMPULAINEN T. and L. ORCI : Ultrastructural immunocytochemical localization of carbonic anhydrase. Histochemistry 75, 209-213 (1982).

231. PATEL Y., AMHERDT M. and L. ORCI : Quantitative electron microscopic autoradiography of insulin, glucagon and somatostatin binding sites on islets. Science 217, 1155-1156 (1982).

232. FEHLMANN M., CARPENTIER J.-L., VAN OBBERGHEN E., FREYCHET P., THAMM P., SAUNDERS D., BRANDENBURG D. and L. ORCI : Internalized insulin receptors are recycled to the cell surface in rat hepatocytes. Proc. Natl. Acad. Sci. USA 79, 5921-5925 (1982).

233. CARPENTIER J.-L., GORDEN P., ANDERSON R.G.W., GOLDSTEIN J.L., BROWN M.S., COHEN S. and L. ORCI : Colocalization of 125I-epidermal growth factor and ferritin-low density lipoprotein in coated pits : a quantitative electron microscopic study in normal and mutant human fibroblasts. J. Cell Biol. 95, 73-77 (1982).

234. BONNER-WEIR S. and L. ORCI : New perspectives on the microvasculature of the islets of Langerhans in the rat. Diabetes 31, 883-889 (1982).

235. HIZUKA N., GORDEN P., LESNIAK M.A., CARPENTIER J.-L. and L. ORCI : Effect of pH and lysosomotropic agents on membrane-associated and internalized (125I)iodo-hGH in cultured human lymphocytes : a quantitative biochemical and electron microscopic study. Endocrinology 111, 1576-1580 (1982).


236. KAWAI K., IPP E., ORCI L., PERRELET A. and R.H. UNGER : Circulating somatostatin acts on the islets of Langerhans via a somatostatin-poor compartment. Science 218, 477-478 (1982).

237. ROTH J., BROWN D., NORMAN A.W. and L. ORCI : Localization of the vitamin D-dependent calcium-binding protein in mammalian kidney. Am. J. Physiol. 243, F243-F252 (1982).

238. FAN J.-Y., CARPENTIER J.-L., GORDEN P., VAN OBBERGHEN E., BLACKETT N.M., GRUNFELD C. and L. ORCI : Receptor-mediated endocytosis of insulin : Role of microvilli, coated pits, and coated vesicles. Proc. Natl. Acad. Sci. USA 79, 7788-7791 (1982).

239. SIPS J.J., BROWN D., OONK R. and L. ORCI : Orientation of rat-liver plasma membrane vesi-cles. A biochemical and ultrastructural study. Biochim. Biophys. Acta 692, 447-454 (1982).

240. GORDEN P., FREYCHET P., CARPENTIER J.-L., CANIVET B. and L. ORCI : Receptor-linked degradation of 125I-insulin is mediated by internalization in isolated rat hepatocytes. Yale J. Biol. & Med. 55, 101-112 (1982).

241. CARPENTIER J.-L., FEHLMANN M., FREYCHET P. and L. ORCI : Receptor binding and internalization of biosynthetic human insulin in isolated rat hepatocytes. Mol. & Cell Endocrinol. 28, 543-550 (1982).

242. RAVAZZOLA M., BENOIT R., LING N., GUILLEMIN R. and L. ORCI : Immunocytochemical localization of prosomatostatin fragments in maturing and mature secretory granules of pancreatic and gastrointestinal D-cells. Proc. Natl. Acad. Sci. USA 80, 215-218 (1983).

243. ORCI L. and D. BROWN : Distribution of filipin-sterol complexes in plasma membranes of the kidney. II. The thin limbs of Henle’s loop. Lab. Invest. 48, 80-89 (1983).

244. MONTESANO R., RAVAZZOLA M. and L. ORCI : Filipin labelling of lipid droplets in lactat-ing rat mammary gland. Cell Biol. Int. Rep. 7, 194 (1983).

245. BROWN D. and L. ORCI : Vasopressin stimulates formation of coated pits in rat kidney collect-ing ducts. Nature 302, 253-255 (1983).

246. STEFAN Y., GRASSO S., PERRELET A. and L. ORCI : A quantitative immunofluorescent study of the endocrine cell populations in the developing human pancreas. Diabetes 32, 293-301 (1983).

247. ROTH J., BROWN D. and L. ORCI : Regional distribution of N-acetyl-D-galactosamine residues in the glycocalyx of glomerular podocytes. J. Cell Biol. 96, 1189-1196 (1983).

248. MONTESANO R., MOSSAZ A., VASSALLI P. and L. ORCI : Specialization of the macrophage plasma membrane at sites of interaction with opsonized erythrocytes. J. Cell Biol. 96, 1227-1233 (1983).

249. FAN J.-Y., CARPENTIER J.-L., VAN OBBERGHEN E., GRUNFELD C., GORDEN P. and L. ORCI : Morphological changes of the 3T3-L1 fibroblast plasma membrane upon differentiation to the adipocyte form. J. Cell Sci. 61, 219-230 (1983).

250. MEDA P., FINDLAY I., KOLOD E., ORCI L. and O.H. PETERSEN : Short and reversible un-coupling evokes little change in the gap junctions of pancreatic acinar cells. J. Ultrastr. Res. 83, 69-84 (1983).

Lelio ORCI Publications - Page 18 -251. FAN J.-Y., CARPENTIER J.-L., VAN OBBERGHEN E., BLACKETT N.M., GRUNFELD C.,

GORDEN P. and L. ORCI : The interaction of 125I-insulin with cultured 3T3-L1 adipocytes : quantitative analysis by the hypothetical grain method. J. Histochem. Cytochem. 31, 859-870 (1983).

252. ORCI L., PERRELET A. and R. MONTESANO : Differential filipin labeling of the luminal membranes lining the pancreatic acinus. J. Histochem. Cytochem. 31, 952-955 (1983).

253. PATEL Y.C., RUGGERE D., MALAISSE-LAGAE F. and L. ORCI : Alterations in somatosta-tin and other islet cell functions in the spontaneously diabetic BB Wistar rat : biochemical and morphological characterization. Metabolism 32, Suppl. 1, 18-25 (1983).

254. KASUGA M., CARPENTIER J.-L., VAN OBBERGHEN E., ORCI L. and P. GORDEN : 125I-anti-insulin receptor FAB is internalized by cultured human lymphocytes. Biochem. & Biophys. Res. Commun. 114, 230-233 (1983).

255. FAN J.-Y., CARPENTIER J.-L., VAN OBBERGHEN E., GRUNFELD C., GORDEN P. and L. ORCI : Surface interactions and intracellular localization of cationic ferritin : similarity to 125I-insulin in 3T3-L1 adipocytes. Eur. J. Cell Biol. 31, 125-131 (1983).

256. BROWN D., KUMPULAINEN T., ROTH J. and L. ORCI : Immunohistochemical localization of carbonic anhydrase in postnatal and adult rat kidney. Am. J. Physiol. 245, F110-F118 (1983).

257. MEDA P., MICHAELS R.L., HALBAN P.A., ORCI L. and J.D. SHERIDAN : In vivo modula-tion of gap junctions and dye coupling between B-cells of the intact pancreatic islet. Diabetes 32, 858-868 (1983).

258. ANDERSON R.G.W., ORCI L., BROWN M.S., GARCIA-SEGURA L.-M. and J.L. GOLD-STEIN : Ultrastructural analysis of crystalloid endoplasmic reticulum in UT-1 cells and its disappearance in response to cholesterol. J. Cell Sci. 63, 1-20 (1983).

259. MONTESANO R., MOURON P., AMHERDT M. and L. ORCI : Collagen matrix promotes reorganization of pancreatic endocrine cell monolayers into islet-like organoids. J. Cell Biol. 97, 935-939 (1983).

260. BERGER M., BORDI C., CUPPERS J.-J., BERCHTOLD P., GRIES F.A., MUNTERFERING H., SAILER R., ZIMMERMANN H. and L. ORCI : Functional and morphologic characteriza-tion of human insulinomas. Diabetes 32, 921-931 (1983).

261. MONTESANO R., ORCI L. and P. VASSALLI : In vitro rapid organization of endothelial cells into capillary-like networks is promoted by collagen matrices. J. Cell Biol. 97, 1648-1652 (1983).

262. ORCI L., RAVAZZOLA M. et A. PERRELET : Liaison membranaire des sites antigéniques à l’insuline dans l’appareil de Golgi des cellules B pancréatiques. C.R. Acad. Sci. Paris 297, 467-470 (1983).

263. BROWN D., KUNZ A., WOHLWEND A., VASSALLI J.-D. et L. ORCI : Détection ultrastruc-turale de l’hétérogénéité du glycocalyx dans les tubes contournés et droits proximaux du rein de rat par la technique de la lectine couplée à l’or. C.R. Acad. Sci. Paris 297, 501-506 (1983).

264. ORCI L., RAVAZZOLA M., AMHERDT M., YANAIHARA C., YANAIHARA N., HALBAN P., RENOLD A.E. and A. PERRELET : Insulin, not C-peptide (proinsulin), is present in crinophagic bodies of the pancreatic B-cell. J. Cell Biol. 98, 222-228 (1984).


265. ROBERT A., GRUNBERGER G., CARPENTIER J.-L., DAYER J.-M., ORCI L. and P. GORDEN : The insulin receptor of a human monocyte-like cell line : Characterization and func-tion. Endocrinology 114, 247-253 (1984).

266. RAVAZZOLA M., PERRELET A., UNGER R.H. and L. ORCI : Immunocytochemical char-acterization of secretory granule maturation in pancreatic A-cells. Endocrinology 114, 481-485 (1984).

267. GARCIA-SEGURA L.-M., BAETENS D., ROTH J., NORMAN A.W. and L. ORCI : Immuno-histochemical mapping of calcium-binding protein immunoreactivity in the rat central nervous system. Brain Res. 296, 75-86 (1984).

268. BROWN D., GARCIA-SEGURA L.-M. and L. ORCI : Carbonic anhydrase is present in olfac-tory receptor cells. Histochemistry 80, 307-309 (1984).

269. HALBAN P.A., AMHERDT M., ORCI L. and A.E. RENOLD : Proinsulin modified by ana-logues of arginine and lysine is degraded rapidly in pancreatic B-cells. Biochem. J. 219, 91-97 (1984).

270. WEIR G.C., HALBAN P.A., MEDA P., WOLLHEIM C.B., ORCI L. and A.E. RENOLD : Dispersed adult rat pancreatic islet cells in culture : A, B, and D cell function. Metabolism 33, 447-453 (1984).

271. ORCI L., BROWN M.S., GOLDSTEIN J.L., GARCIA-SEGURA L.-M. and R.G.W. ANDER-SON : Increase in membrane cholesterol : A possible trigger for degradation of HMG CoA reductase and crystalloid endoplasmic reticulum in UT-1 cells. Cell 36, 835-845 (1984).

272. KUNZ A., BROWN D. and L. ORCI : Appearance of Helix pomatia lectin-binding sites on po-docyte plasma membrane during glomerular differentiation : A quantitative analysis using the lectin-gold technique. Lab. Invest. 51, 317-324 (1984).

273. ORCI L., HALBAN P., AMHERDT M., RAVAZZOLA M., VASSALLI J.-D. and A. PERRE-LET : A clathrin-coated, Golgi-related compartment of the insulin secreting cell accumulates proinsulin in the presence of monensin. Cell 39, 39-47 (1984).

274. BRUHLMANN-PAPAZYAN M., GARCIA-SEGURA L.-M., PIZZOLATO G.P., NORMAN A.W. and L. ORCI : Immunohistochemically detectable vitamin D-dependent calcium-binding protein is reduced in cerebellum of diabetic subjects. Diabetes 33, 917-922 (1984).

275. MONTESANO R., MOSSAZ A., RYSER J.-E., ORCI L. and P. VASSALLI : Leukocyte inter-leukins induce cultured endothelial cells to produce a highly organized, glycosaminoglycan-rich pericellular matrix. J. Cell Biol. 99, 1706-1715 (1984).

276. CARPENTIER J.-L., DAYER J.-M., LANG U., SILVERMAN R., ORCI L. and P. GORDEN : Down regulation and recycling of insulin receptors. J. Biol. Chem. 259, 14190-14195 (1984).

277. MARUYAMA H., HISATOMI A., ORCI L., GRODSKY G.M. and R.H. UNGER : Insulin within islet is a physiologic glucagon release inhibitor. J. Clin. Invest. 74, 2296-2299 (1984).

278. BROWN D., GARCIA-SEGURA L.-M. and L. ORCI : Carbonic anhydrase is associated with taste buds in rat tongue. Brain Res. 324, 346-348 (1984).

Lelio ORCI Publications - Page 20 -279. ORCI L., KUNZ A., AMHERDT M. and D. BROWN : Perturbation of podocyte plasma mem-

brane domains in experimental nephrosis : A lectin-binding and freeze-fracture study. Am. J. Pathol. 117, 286-297 (1984).

280. ORCI L., RAVAZZOLA M. and A. PERRELET : (Pro)insulin associates with Golgi membranes of pancreatic B-cells. Proc. Natl. Acad. Sci. USA 81, 6743-6746 (1984).

281. ORCI L., RAVAZZOLA M., LOUVARD D. et A. PERRELET : Distribution asymétrique de la clathrine au niveau de l’appareil de Golgi de cellules sécrétoires à polypeptides. C.R. Acad. Sci. Paris 299, 697-702 (1984).

282.ORCI L., HALBAN P., AMHERDT M., RAVAZZOLA M., VASSALLI J.-D. and A. PERRELET : Nonconverted, amino acid analog-modified proinsulin stays in a Golgi-derived clathrin-coated membrane compartment. J. Cell Biol. 99, 2187-2192 (1984).

283.YANAIHARA C., MATSUMOTO T., NISHIDA T., UCHIDA T., KOBAYASHI S., MOODY A.J., ORCI L. and N. YANAIHARA : Chemical approach to develop glicentin C-terminal specific radioimmunoassay. Biomed. Res. 5, Suppl., 19-32 (1984).

284.BEARER E.L. and L. ORCI : Endothelial fenestral diaphragms : A quick-freeze-deep-etch study. J. Cell Biol. 100, 418-428 (1985).

285.LOMBARDI T., MONTESANO R., WOHLWEND A., AMHERDT M., VASSALLI J.-D. and L. ORCI : Evidence for polarization of plasma membrane domains in pancreatic endocrine cells. Nature 313, 694-696 (1985).

286.MONTESANO R., ORCI L. and P. VASSALLI : Human endothelial cell cultures : Phenotypic modulation by leucocyte interleukins. J. Cell Physiol. 122, 424-434 (1985).

287.HISATOMI A., MARUYAMA H., ORCI L., VASKO M. and R.H. UNGER : Adrenergically medi-ated intrapancreatic control of the glucagon response to glucopenia in the isolated rat pancreas. J. Clin. Invest. 75, 420-426 (1985).

288.PATEL Y.C., PIERZCHALA I., AMHERDT M. and L. ORCI : Effects of cysteamine and antibody to somatostatin on islet cell function in vitro. Evidence that intracellular somatostatin deficiency augments insulin and glucagon secretion. J. Clin. Invest. 75, 1249-1255 (1985).

289.BROWN D., ROTH J. and L. ORCI : Lectin-gold cytochemistry reveals intercalated cell hetero-geneity along rat kidney collecting ducts. Am. J. Physiol. 248, C348-C356 (1985).

290.ROBERT A., CARPENTIER J.-L., VAN OBBERGHEN E., CANIVET B., GORDEN P. and L. ORCI : The endosomal compartment of rat hepatocytes. Its characterization in the course of [125I] insulin internalization. Exp. Cell Res. 159, 113-126 (1985).

291.GRUNBERGER G., ROBERT A., CARPENTIER J.-L., DAYER J.-M., ROTH A., STEVENSON H.C., ORCI L. and P. GORDEN : Human circulating monocytes internalize 125I-insulin in a similar fashion to rat hepatocytes : Relevance to receptor regulation in target and nontarget tissues. J. Lab. Clin. Med. 106, 211-217 (1985).

292.ORCI L., RAVAZZOLA M., AMHERDT M., LOUVARD D. and A. PERRELET : Clathrin immunoreactive sites in the Golgi apparatus are concentrated at the trans pole in polypeptide hormone-secreting cells. Proc. Natl. Acad. Sci. USA 82, 5385-5389 (1985).


293.CARPENTIER J.-L., BROWN D., IACOPETTA B. and L. ORCI : Detection of surface-bound ligands by freeze-fracture autoradiography. J. Cell Biol. 101, 887-890 (1985).

294.MONTESANO R. and L. ORCI : Tumor-promoting phorbol esters induce angiogenesis in vitro. Cell 42, 469-477 (1985).

295.ORCI L., RAVAZZOLA M., AMHERDT M., MADSEN O., VASSALLI J.-D. and A. PERRELET : Direct identification of prohormone conversion site in insulin-secreting cells. Cell 42, 671-681 (1985).

296.PODSKALNY J.M., TAKEDA S., SILVERMAN R.E., TRAN D., CARPENTIER J.-L., ORCI L. and P. GORDEN : Insulin receptors and bioresponses in a human liver cell line (Hep G-2). Eur. J. Biochem. 150, 401-407 (1985).

297.MONTESANO R., MOURON P. and L. ORCI : Vascular outgrowths from tissue explants em-bedded in fibrin or collagen gels : A simple in vitro model of angiogenesis. Cell Biol. Int. Rep. 9, 869-875 (1985).

298.KUNZ A., BROWN D., VASSALLI J.-D., KONTURRI M., KUMPULAINEN T. and L. ORCI : Ultrastructural localization of glycocalyx domains in human kidney podocytes using the lectin-gold technique. Lab. Invest. 53, 413-420 (1985).

299.CARPENTIER J.-L., FEHLMANN M., VAN OBBERGHEN E., GORDEN P. and L. ORCI : Redistribution of 125I-insulin on the surface of rat hepatocytes as a function of dissociation time. Diabetes 34, 1002-1007 (1985).

300.LOMBARDI T., MONTESANO R. and L. ORCI : Polarized plasma membrane domains in cul-tured endothelial cells. Exp. Cell Res. 161, 243-246 (1985).

301.BROWN D., SHIELDS G.I., VALTIN H., MORRIS J.F. and L. ORCI : Lack of intramembranous particle clusters in collecting ducts of mice with nephrogenic diabetes insipidus. Am. J. Physiol. 249, F582-F589 (1985).

302.MARUYAMA H., TOMINAGA M., BOLLI G., ORCI L. and R.H. UNGER : The alpha cell response to glucose change during perfusion of anti-insulin serum in pancreas isolated from normal rats. Diabetologia 28, 836-840 (1985).

303.BAETENS D., VASKO M., UNGER R.H. and L. ORCI : Ultrastructural detection of granulated cells in the autonomic ganglia of the rat pancreas. Diabetologia 28, 841-846 (1985).

304.WOHLWEND A., MONTESANO R., VASSALLI J.-D. and L. ORCI : LLC-PK1 cysts : A model for the study of epithelial polarity. J. Cell Physiol. 125, 533-539 (1985).

305.STEFAN Y., BORDI C., GRASSO S. and L. ORCI : Beckwith-Wiedemann syndrome : A quantita-tive, immunohistochemical study of pancreatic islet cell populations. Diabetologia 28, 914-919 (1985).

306.SAWANO F., RAVAZZOLA M., AMHERDT M., PERRELET A. and L. ORCI : Horseradish per-oxidase uptake and crinophagy in insulin-secreting cells. Exp. Cell Res. 164, 174-182 (1986).

307.BEARER E.L. and L. ORCI : A simple method for quick-freezing. J. Electron Microsc. Tech. 3, 233-241 (1986).

Lelio ORCI Publications - Page 22 -308.CARPENTIER J.-L., GAZZANO H., VAN OBBERGHEN E., FEHLMANN M., FREYCHET P.

and L. ORCI : Intracellular pathway followed by the insulin receptor covalently coupled to 125I-photoreactive insulin during internalization and recycling. J. Cell Biol. 102, 989-996 (1986).

309.LOMBARDI T., MONTESANO R.L, FURIE M.B., SILVERSTEIN S.C. and L. ORCI : Endothe-lial diaphragmed fenestrae : In vitro modulation by phorbol myristate acetate. J. Cell Biol. 102, 1965-1970 (1986).

310.HALBAN P.A., AMHERDT M., ORCI L. and A.E. RENOLD : Tris-(hydroxymethyl)aminomethane inhibits the synthesis and processing of proinsulin in isolated rat pancreatic islets without affecting release of insulin stores. Diabetes 35, 433-439 (1986).

311.CARPENTIER J.-L., ROBERT A., GRUNBERGER G., VAN OBBERGHEN E., FREYCHET P., ORCI L. and P. GORDEN : Receptor-mediated endocytosis of polypeptide hormones is a regulated process : Inhibition of 125I-insulin internalization in hypoinsulinemic diabetes of rat and man. J. Clin. Endocrinol. & Metab. 63, 151-155 (1986).

312.LOMBARDI T., MONTESANO R. and L. ORCI : Loss of polarization of plasma membrane domains in transformed pancreatic endocrine cell lines. Endocrinology 119, 502-507 (1986).

313.MEDA P., BRUZZONE R., KNODEL S. and L. ORCI : Blockage of cell-to-cell communication within pancreatic acini is associated with increased basal release of amylase. J. Cell Biol. 103, 475-483 (1986).

314.ORCI L., GLICK B.S. and J.E. ROTHMAN : A new type of coated vesicular carrier that appears not to contain clathrin : Its possible role in protein transport within the Golgi stack. Cell 46, 171-184 (1986).

315.MOJSOV S., HEINRICH G., WILSON I.B., RAVAZZOLA M., ORCI L. and J.F. HABENER : Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-trans-lational processing. J. Biol. Chem. 261, 11880-11889 (1986).

316.IACOPETTA B., CARPENTIER J.-L., POZZAN T., LEW D.P., GORDEN P. and L. ORCI : Role of intracellular calcium and protein kinase C in the endocytosis of transferrin and insulin by HL60 cells. J. Cell Biol. 103, 851-856 (1986).

317.BROWN D. and L. ORCI : The “coat” of kidney intercalated cell tubulovesicles does not contain clathrin. Am. J. Physiol. 250, C605-C608 (1986).

318.WOHLWEND A., VASSALLI J.-D., BERTRAND D. and L. ORCI : Calcitonin and vasopressin affect epithelial properties in a renal cell line. J. Cell Physiol. 128, 71-75 (1986).

319.BROWN D. and L. ORCI : Interactions of lectins with specific cell types in toad urinary bladder : Surface distribution revealed by colloidal gold probes and label fracture. J. Histochem. Cyto-chem. 34, 1057-1062 (1986).

320.ORCI L., RAVAZZOLA M., AMHERDT M., BROWN D. and A. PERRELET : Transport of horseradish peroxidase from the cell surface to the Golgi in insulin-secreting cells : Preferential labelling of cisternae located in an intermediate position in the stack. EMBO J. 5, 2097-2101 (1986).

321.CARPENTIER J.-L., GAZZANO H., VAN OBBERGHEN E., FEHLMANN M., FREYCHET P. and L. ORCI : Internalization and recycling of 125I-photoreactive insulin-receptor complexes in hepatocytes in primary culture. Mol. & Cell. Endocrinol. 47, 243-255 (1986).


322.CARPENTIER J.-L., REES A.R., GREGORIOU M., KRIS R., SCHLESSINGER J. and L. ORCI : Subcellular distribution of the external and internal domains of the EGF receptor in A-431 cells. Exp. Cell Res. 166, 312-326 (1986).

323.VASSALLI J.-D., LOMBARDI T., WOHLWEND A., MONTESANO R. and L. ORCI : Direct cell-to-cell transmission of vesicular stomatitis virus. J. Cell Sci. 85, 125-131 (1986).

324.MONTESANO R., VASSALLI J.-D., BAIRD A., GUILLEMIN R. and L. ORCI : Basic fibroblast growth factor induces angiogenesis in vitro. Proc. Natl. Acad. Sci. USA 83, 7297-7301 (1986).

325.WOHLWEND A., VASSALLI J.-D., BELIN D. and L. ORCI : LLC-PK1 cells : Cloning of phe-notypically stable subpopulations. Am. J. Physiol. 250, C682-C687 (1986).

326.FOURNET N., GARCIA-SEGURA L.-M., NORMAN A.W. and L. ORCI : Selective localization of calcium-binding protein in human brainstem, cerebellum and spinal cord. Brain Res. 399, 310-316 (1986).

327.ORCI L., RAVAZZOLA M., AMHERDT M., MADSEN O., PERRELET A., VASSALLI J.-D. and R.G.W. ANDERSON : Conversion of proinsulin to insulin occurs coordinately with acidification of maturing secretory vesicles. J. Cell Biol. 103, 2273-2281 (1986).

328.TOMINAGA M., KOMIYA I., JOHNSON J.H., INMAN L., ALAM T., MOLTZ J., CRIDER B., STEFAN Y., BAETENS D., McCORKLE K., ORCI L. and R.H. UNGER : Loss of insulin response to glucose but not arginine during the development of autoimmune diabetes in BB/W rats : Relationships to islet volume and glucose transport rate. Proc. Natl. Acad. Sci. USA 83, 9749-9753 (1986).

329.ORCI L., RAVAZZOLA M. and R.G.W. ANDERSON : The condensing vacuole of exocrine cells is more acidic than the mature secretory vesicle. Nature 326, 77-79 (1987).

330.MONTESANO R. and L. ORCI : Phorbol esters induce angiogenesis in vitro from large vessel endothelial cells. J. Cell Physiol. 130, 284-291 (1987).

331.TOMINAGA M., MARUYAMA H., VASKO M.R., BAETENS D., ORCI L. and R.H. UNGER : Morphologic and functional changes in sympathetic nerve relationships with pancreatic α-cells after destruction of β-cells in rats. Diabetes 36, 365-373 (1987).

332.PATEL Y.C., RAVAZZOLA M., AMHERDT M. and L. ORCI : Somatostatin-14-like antigenic sites in fixed islet D-cells are unaltered by cysteamine. A quantitative electron microscopic immunocytochemical evaluation. Endocrinology 120, 1663-1667 (1987).

333.HALBAN P.A., MUTKOSKI R., DODSON G. and L. ORCI : Resistance of the insulin crystal to lysosomal proteases : Implications for pancreatic B-cell crinophagy. Diabetologia 30, 348-353 (1987).

334.ORCI L., RAVAZZOLA M., STORCH M.-J., ANDERSON R.G.W., VASSALLI J.-D. and A. PERRELET : Proteolytic maturation of insulin is a post-Golgi event which occurs in acidifying clathrin-coated secretory vesicles. Cell 49, 865-868 (1987).

335.STEFAN Y., MEDA P., NEUFELD M. and L. ORCI : Stimulation of insulin secretion reveals heterogeneity of pancreatic B cells in vivo. J. Clin. Invest. 80, 175-183 (1987).

Lelio ORCI Publications - Page 24 -336.RHODES C.J., LUCAS C.A., MUTKOSKI R.L., ORCI L. and P.A. HALBAN : Stimulation by

ATP of proinsulin to insulin conversion in isolated rat pancreatic islet secretory granules. J. Biol. Chem. 262, 10712-10717 (1987).

337.LOMBARDI T., MONTESANO R. and L. ORCI : Phorbol ester induces diaphragmed fenestrae in large vessel endothelium in vitro. Eur. J. Cell Biol. 44, 86-89 (1987).

338.BROWN D., WEYER P. and L. ORCI : Non-clathrin coated vesicles are involved in endocytosis in kidney collecting duct intercalated cells. Anat. Rec. 218, 237-242 (1987).

339.RIELLE J.-C., BROWN D. and L. ORCI : Differences in glycocalyx composition between cells of the cortical thick ascending limb of Henle and the macula densa revealed by lectin-gold cy-tochemistry. Anat. Rec. 218, 243-248 (1987).

340.MEDA P., BRUZZONE R., CHANSON M., BOSCO D. and L. ORCI : Gap junctional coupling modulates secretion of exocrine pancreas. Proc. Natl. Acad. Sci. USA 84, 4901-4904 (1987).

341.STEINER D.F., MICHAEL J., HOUGHTEN R., MATHIEU M., GARDNER P.R., RAVAZZOLA M. and L. ORCI : Use of a synthetic peptide antigen to generate antisera reactive with a proteolytic processing site in native human proinsulin : Demonstration of cleavage within clathrin-coated (pro)secretory vesicles. Proc. Natl. Acad. Sci. USA 84, 6184-6188 (1987).

342.MONTESANO R., PEPPER M.S., VASSALLI J.-D. and L. ORCI : Phorbol ester induces cul-tured endothelial cells to invade a fibrin matrix in the presence of fibrinolytic inhibitors. J. Cell Physiol. 132, 509-516 (1987).

343.KNODEL S., MEDA P. and L. ORCI : Rapid in vitro formation of smooth endoplasmic reticulum aggregates within peptide-producing islet cells. J. Cell Physiol. 133, 111-118 (1987).

344.TRAN D., CARPENTIER J.-L., SAWANO F., GORDEN P. and L. ORCI : Ligands internalized through coated or noncoated invaginations follow a common intracellular pathway. Proc. Natl. Acad. Sci USA 84, 7957-7961 (1987).

345.ORCI L., RAVAZZOLA M., AMHERDT M., PERRELET A., POWELL S.K., QUINN D.L. and H.-P.H. MOORE : The trans-most cisternae of the Golgi complex : A compartment for sorting of secretory and plasma membrane proteins. Cell 51, 1039-1051 (1987).

346.MELANCON P., GLICK B.S., MALHOTRA V., WEIDMAN P.J., SERAFINI T., GLEASON M.L., ORCI L. and J.E. ROTHMAN : Involvement of GTP-binding “G” proteins in transport through the Golgi stack. Cell 51, 1053-1062 (1987).

347.AMHERDT M., PATEL Y.C. and L. ORCI : Selective binding of somatostatin-14 and somato-statin-28 to islet cells revealed by quantitative electron microscopic autoradiography. J. Clin. Invest. 80, 1455-1458 (1987).

348.PEPPER M.S., VASSALLI J.-D., MONTESANO R. and L. ORCI : Urokinase-type plasmino-gen activator is induced in migrating capillary endothelial cells. J. Cell Biol. 105, 2535-2541 (1987).

349.CARPENTIER J.-L., WHITE M.F., ORCI L. and R.C. KAHN : Direct visualization of the phos-phorylated epidermal growth factor receptor during its internalization in A-431 cells. J. Cell Biol. 105, 2751-2762 (1987).

Lelio ORCI Publications - Page 25 -350.ANDERSON R.G.W. and L. ORCI : A view of acidic intracellular compartments. J. Cell Biol.

106, 539-543 (1988).

351.HUTTON J.C., PESHAVARIA M., JOHNSTON C.F., RAVAZZOLA M. and L. ORCI : Immu-nolocalization of betagranin : a chromogranin A-related protein of the pancreatic β-cell. Endo-crinology 122, 1014-1020 (1988).

352.WEYER P., BROWN D. and L. ORCI : Lectin-gold labeling of glycoconjugates in normal and Brattleboro rat papilla : Effect of vasopressin. Am. J. Physiol. 254, 450-458 (1988).

353.MONTESANO R., PEPPER M.S., BELIN D., VASSALLI J.-D. and L. ORCI : Induction of an-giogenesis in vitro by vanadate, an inhibitor of phosphotyrosine phosphatases. J. Cell Physiol. 134, 460-466 (1988).

354.MONTESANO R. and L. ORCI : Intracellular diaphragmed fenestrae in cultured capillary en-dothelial cells. J. Cell Science 89, 441-447 (1988).

355.BROWN D. and L. ORCI : Junctional complexes and cell polarity in the urinary tubule. J. Electr. Microsc. Tech. 9, 145-170 (1988).

356.BROWN D., WEYER P. and L. ORCI : Vasopressin stimulates endocytosis in kidney collecting duct principal cells. Eur. J. Cell Biol. 46, 336-341 (1988).

357.RAVAZZOLA M., EFENDIC S., OSTENSON C.G., TATEMOTO K., HUTTON J.C. and L. ORCI: Localization of pancreastatin immunoreactivity in porcine endocrine cells. Endocrinol-ogy 123, 227-229 (1988).

358.POWELL S.K., ORCI L., CRAIK C.S. and H.-P.H. MOORE : Efficient targeting to storage granules of human proinsulins with altered propeptide domain. J. Cell Biol. 106, 1843-1851 (1988).

359.MONTESANO R. and L. ORCI : Transforming growth factor β stimulates collagen matrix con-traction by fibroblasts : implications for wound healing. Proc. Natl. Acad. Sci. USA 85, 4894-4897 (1988).

360.MALHOTRA V., ORCI L., GLICK B.S., BLOCK M.R. and J.E. ROTHMAN : Role of an N-ethylmaleimide-sensitive transport component in promoting fusion of transport vesicles with cisternae of the Golgi stack. Cell 54, 221-227 (1988).

361.LOMBARDI T., MONTESANO R., FURIE M.B., SILVERSTEIN S.C. and L. ORCI : In vitro modulation of endothelial fenestrae : opposing effects of retinoic acid and transforming growth factor β. J. Cell Sci. 91, 313-318 (1988).

362.NOE B., AMHERDT M., PERRELET A. and L. ORCI : Simultaneous assessment of prohormone transport and processing in four separate islet cell types : A combined autoradiographic and biochemical study. Pancreas 3, 700-713 (1988).

363.ORCI L., MALHOTRA V., AMHERDT M., SERAFINI T. and J.E. ROTHMAN : Dissection of a single round of vesicular transport : Sequential intermediates for intercisternal movement in the Golgi stack. Cell 56, 357-368 (1989).

364.RAVAZZOLA M., BENOIT R., LING N. and L. ORCI : Prosomatostatin-derived antrin is present in gastric D-cells and in portal blood. J. Clin. Invest. 83, 362-366 (1989).

Lelio ORCI Publications - Page 26 -365.SKALLI O., PELTE M.-F., PECLET M.-C., GABBIANI G., GUGLIOTTA P., BUSSOLATI G.,

RAVAZZOLA M. and L. ORCI : A-smooth muscle actin, a differentiation marker of smooth muscle cells, is present in microfilamentous bundles of pericytes. J. Histochem. Cytochem. 37, 315-321 (1989).

366.CARPENTIER J.-L., SAWANO F., GEIGER D., GORDEN P., PERRELET A. and L. ORCI : Potassium depletion and hypertonic medium reduce “non-coated” and clathrin-coated pit forma-tion, as well as endocytosis through these two gates. J. Cell Physiol. 138, 519-526 (1989).

367.MALHOTRA V., SERAFINI T., ORCI L., SHEPHERD J.C. and J.E. ROTHMAN : Purification of a novel class of coated vesicles mediating biosynthetic protein transport through the Golgi stack. Cell 58, 329-336 (1989).

368.ORCI L., THORENS B., RAVAZZOLA M. and H.F. LODISH : Localization of the pancreatic beta cell glucose transporter to specific plasma membrane domains. Science 245, 295-297 (1989).

369.BOSCO D., ORCI L. and P. MEDA : Homologous but not heterologous contact increases the insulin secretion of individual pancreatic β-cells. Exp. Cell Res. 184, 72-80 (1989).

370.AMHERDT M., PATEL Y.C. and L. ORCI : Binding and internalization of somatostatin, insulin and glucagon by cultured rat islet cells. J. Clin. Invest. 84, 412-417 (1989).

371.PFANNER N., ORCI L., GLICK B.S., AMHERDT M., ARDEN S.R., MALHOTRA V. and J.E. ROTHMAN : Fatty acyl-coenzyme A is required for budding of transport vesicles from Golgi cisternae. Cell 59, 95-102 (1989).

372.GEIGER D., CARPENTIER J.-L., GORDEN P. and L. ORCI : Down-regulation of insulin recep-tors is related to insulin internalization. Exp. Cell Res. 185, 33-40 (1989).

373.PEPPER M.S., SPRAY D.C., CHANSON M., MONTESANO R., ORCI L. and P. MEDA : Junctional communication is induced in migrating capillary endothelial cells. J. Cell Biol. 109, 3027-3038 (1989).

374.PEPPER M.S., BELIN D., MONTESANO R., ORCI L. and J.-D. VASSALLI : Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro. J. Cell Biol. 111, 743-755 (1990).

375.ESTREICHER A., MUHLHAUSER J., CARPENTIER J.-L., ORCI L. and J.-D. VASSALLI : The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes. J. Cell Biol. 111, 783-792 (1990).

376.MONTESANO R., PEPPER M.S., MOHLE-STEINLEIN U., RISAU W., WAGNER E.F. and L. ORCI : Increased proteolytic activity is responsible for the aberrant morphogenetic behavior of endothelial cells expressing the middle T oncogene. Cell 62, 435-445 (1990).

377.MEDA P., BOSCO D., CHANSON M., GIORDANO E., VALLAR L., WOLLHEIM C. and L. ORCI : Rapid and reversible secretion changes during uncoupling of rat insulin-producing cells. J. Clin. Invest. 86, 759-768 (1990).

378.JOHNSON J.H. OGAWA A., CHEN L., ORCI L., NEWGARD C.B., ALAM T. and R.H. UNGER : Underexpression of β-cell high K m glucose transporters in noninsulin-dependent diabetes. Sci-ence 250, 546-549 (1990).

Lelio ORCI Publications - Page 27 -379.ORCI L., UNGER R.H., RAVAZZOLA M., OGAWA A., KOMIYA I., BAETENS D., LODISH

H.F. and B. THORENS : Reduced β-cell glucose transporter in new onset diabetic BB rats. J. Clin. Invest. 86, 1615-1622 (1990).

380.ORCI L., RAVAZZOLA M., BAETENS D., INMAN L., AMHERDT M., PETERSON R.G., NEWGARD C.B., JOHNSON J.H. and R.H. UNGER : Evidence that down-regulation of β-cell glucose transporters in non-insulin-dependent diabetes may be the cause of diabetic hyperglyc-emia. Proc. Natl. Acad. Sci. USA 87, 9953-9957 (1990).

381.HARTWIG J.H., BROWN D., AUSIELLO D.A., STOSSEL T.P. and L. ORCI : Polarization of gelsolin and actin binding protein in kidney epithelial cells. J. Histochem. Cytochem. 38, 1145-1153 (1990).

382.KOMIYA I., BAETENS D., KUWAJIMA M., ORCI L. and R.H. UNGER : Compensatory ca-pabilities of islets of BB/Wor rats exposed to sustained hyperglycemia. Metabolism 39, No 6, 614-618 (1990).

383.SERAFINI T., STENBECK G., BRECHT A., LOTTSPEICH F., ORCI L., ROTHMAN J.E. and F.T. WIELAND : A coat subunit of Golgi-derived non-clathrin-coated vesicles with homology to the clathrin-coated vesicle coat protein β-adaptin. Nature 349, 215-220 (1991).

384.MEDA P., CHANSON M., PEPPER M., GIORDANO E., BOSCO D., TRAUB O., WILLECKE K., AL AOUMARI A., GROS D., BEYER E.C., ORCI L. and D.C. SPRAY : In vivo modulation of connexin 43 gene expression and junctional coupling of pancreatic β-cells. Exp. Cell Res. 192, 469-480 (1991).

385.PEPPER M.S., MONTESANO R., VASSALLI J.-D. and L. ORCI : Chondrocytes inhibit endothe-lial sprout formation in vitro : Evidence for involvement of a transforming growth factor-β. J. Cell. Physiol. 146, 170-179 (1991).

386.PEPPER M.S., MONTESANO R., ORCI L. and J.-D. VASSALLI : Plasminogen activator inhibi-tor-1 is induced in microvascular endothelial cells by a chondrocyte-derived transforming growth factor-β. Biochem. Biophys. Res. Commun. 176, 633-638 (1991).

387.ORCI L., TAGAYA M., AMHERDT M., PERRELET A., DONALDSON J.G., LIPPINCOTT-SCHWARTZ J., KLAUSNER R.D. and J.E. ROTHMAN : Brefeldin A, a drug that blocks secre-tion, prevents the assembly of non-clathrin-coated buds on Golgi cisternae. Cell 64, 1183-1195 (1991).

388.QUINN D., ORCI L., RAVAZZOLA M. and H.-P.H. MOORE : Intracellular transport and sorting of mutant human proinsulins that fail to form hexamers. J. Cell Biol. 113, 987-996 (1991).

389.MONTESANO R., SCHALLER G. and L. ORCI : Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factors. Cell 66, 697-711 (1991).

390.CHANSON M., ORCI L. and P. MEDA : Extent and modulation of junctional communication between pancreatic acinar cells in vivo. Am. J. Physiol. 261, G28-G36 (1991).

391.ORCI L., RAVAZZOLA M., MEDA P., HOLCOMB C., MOORE H.-P., HICKE L. and R. SCHEK-MAN : Mammalian Sec23p homologue is restricted to the endoplasmic reticulum transitional cytoplasm. Proc. Natl. Acad. Sci. USA 88, 8611-8615 (1991).

392.SERAFINI T., ORCI L., AMHERDT M., BRUNNER M., KAHN R.A. and J.E. ROTHMAN : ADP-ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles : a novel role for a GTP-binding protein. Cell 67, 239-253 (1991).


393.LIPPINCOTT-SCHWARTZ J., YUAN L., TIPPER C., AMHERDT M., ORCI L. and R.D. KLAUS-NER : Brefeldin A’s effects on endosomes, lysosomes and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic. Cell 67, 601-616 (1991).

394.MONTESANO R., MATSUMOTO K., NAKAMURA T and L. ORCI : Identification of a fibrob-last-derived epithelial morphogen as hepatocyte growth factor. Cell 67, 901-908 (1991).

395.HERRERA P.-L., HUARTE J., SANVITO F., MEDA P., ORCI L. and J.-D. VASSALLI : Em-bryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene. Development 113, 1257-1265 (1991).

396.PEPPER M.S., FERRARA N., ORCI L. and R. MONTESANO : Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. Biochem. Biophys. Res. Commun. 181, 902-906 (1991).

397.WILSON D.W., WHITEHEART S.W., ORCI L. and J.E. ROTHMAN : Intracellular membrane fusion. TIBS 16, 334-337 (1991).

398.GUEST P.C., RAVAZZOLA M., DAVIDSON H.W., ORCI L. and J.C. HUTTON : Molecular heterogeneity and cellular localization of carboxypeptidase H in the islets of langerhans. Endo-crinology 129, No 2, 734-740 (1991)

399.ROTHMAN J.E. and L. ORCI : Molecular dissection of the secretory pathway. Nature 355, 409-415 (1992).

400.CARPENTIER J.-L., PACCAUD J.-P., GORDEN P., RUTTER W.J. and L. ORCI : Insulin-induced surface redistribution regulates internalization of the insulin receptor and requires its autophos-phorylation. Proc. Natl. Acad. Sci. USA 89, 162-166 (1992).

401.PEPPER M.S., MONTESANO R., EL AOUMARI A., GROS D., ORCI L., and MEDA P.: Cou-pling and connexin 43 expression in microvascular and large vessel endothelial cells. Am. J. Physiol. 262 (Cell Physiol. 31): C1246-C1257, 1992.

402.KAHN R.A., RANDAZZO P., SERAFINI T., WEISS O., RULKA C., CLARK J., AMHERDT M., ROLLER P., ORCI L. and J.E. ROTHMAN : The amino terminus of ADP ribosylation factor (ARF) is a critical determinant of ARF activities and is a potent and specific inhibitor of protein transport. J. Biol.Chem. 267, 13039-13046 (1992).

403.PEPPER M.S., MATSUMOTO K., NAKAMURA T., ORCI L. and R. MONTESANO : Hepa-tocyte growth factor increases urokinase-type plasminogen activator (u-PA) and u-PA receptor expression MDCK epithelial cells. J. Biol. Chem. 267 : 20493-20496 (1992).

404.PEPPER M.S., SAPPINO A.P., MONTESANO R., ORCI L. and J.-D. VASSALLI : Plasmino-gen activator inhibitor-1 is induced in migrating endothelial cells. J. Cell Physiol. 153, 129-139 (1992).

405.PEPPER M.S., FERRARA N., ORCI L. and R. MONTESANO : Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro. Biochem. Biophys. Res. Comm. 189, No 2, 824-831 (1992).

406.HIGUCHI Y., HERRERA P., MUNIESA P., HUARTE J., BELIN D., OHASHI P., AICHELE P., ORCI L., VASSALLI J.-D. and P. VASSALLI : Expression of a tumor necrosis factor a transgene in murine pancreatic β-cells results in severe and permanent insulitis without evolution towards diabetes. J. Exp. Med. 176, 1719-1731 (1992).


407.PEPPER M.S., VASSALLI J.-D., ORCI L. and R. MONTESANO : Biphasic effect of transforming growth factor-beta 1 on in vitro angiogenesis. Exp. Cell Research 204, 356-363 (1993).

408.MONTESANO R., PEPPER M.S. and L. ORCI : Paracrine induction of angiogenesis in vitro by Swiss 3T3 fibroblasts. J. Cell Sci. 105, 1013-1024 (1993).

409.CARPENTIER J.-L., PACCAUD J.-P., BACKER J., GILBERT A., ORCI L. and C.R. KAHN : Two steps of insulin receptor internalization depend on different domains of the β-subunit. J. Cell Biol. 122, 1243-1252 (1993).

410.OHNEDA M., JOHNSON J.H., INMAN L.R., CHEN L., SUZUKI K.-I., GOTO Y., ALAM T., RAVAZZOLA M., ORCI L. and R.H. UNGER : Glut2 expression and function in β-cells of GK rats with NIDDM. Dissociation between reductions in glucose transport and glucose-stimulated insulin secretion. Diabetes 42, 1065-1072 (1993).

411.STENBECK G., HARTER C., BRECHT A., HERRMANN D., LOTTSPEICH F., ORCI L. and F.T. WIELAND : β’-COP, a novel subunit of coatomer. EMBO J. 12, 2841-2845 (1993).

412.PALMER D.J., HELMS J.B., BECKERS C.J.M., ORCI L. and J.E. ROTHMAN : Binding of coatomer to Golgi membranes requires ADP-ribosylation factor. J. Biol. Chem. 268, 12083-12089 (1993).

413.ORCI L., PALMER D.J., RAVAZZOLA M., PERRELET A., AMHERDT M. and J.E. ROTHMAN : Budding from Golgi membranes requires the coatomer complex of non-clathrin coat proteins. Nature 362, 648-652 (1993).

414.ORCI L., PALMER D.J., AMHERDT M. and J.E. ROTHMAN : Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol. Nature 364, 732-734 (1993).

415. PEPPER M.S., SAPPINO A.-P., STOCKLIN R., MONTESANO R., ORCI L. and J.D. VAS-SALLI : Upregulation of urokinase receptor expression on migrating endothelial cells. J. Cell Biol. 122, 673-684 (1993).

416. MEDA P., PEPPER M.S., TRAUB O., WILLECKE K., GROS D., BEYER E., NICHOLSON B., PAUL D. and L. ORCI : Differential expression of gap junction connexins in endocrine and exocrine glands. Endocrinology 133, 2371-2378 (1993).

417. ORCI L., PERRELET A., RAVAZZOLA M., WIELAND F.T., SCHEKMAN R. and J.E. ROTHMAN : “BFA bodies” : a subcompartment of the endoplasmic reticulum. Proc. Natl. Acad. Sci USA 90, 11089-11093 (1993).

418. OSTERMANN J., ORCI L., TANI K., AMHERDT M., RAVAZZOLA M. and J.E. ROTHMAN: Stepwise assembly of functionally active transport vesicles. Cell 75, 1015-1025 (1993).

419. TANIGAWA G., ORCI L., AMHERDT M., RAVAZZOLA M., HELMS J.B. and J.E. ROTHMAN : Hydrolysis of bound GTP by ARF protein triggers uncoating of Golgi-derived COP-coated vesicles. J. Cell Biol. 123, 1365-1371 (1993).

420. KUGE O., HARA-KUGE S., ORCI L., RAVAZZOLA M., AMHERDT M., TANIGAWA G., WIELAND F.T. and J.E. ROTHMAN : ξ-COP, a subunit of coatomer, is required for COP-coated vesicle assembly. J. Cell Biol. 123, 1727-1734 (1993).

Lelio ORCI Publications - Page 30 -421. HARA-KUGE S., KUGE O., ORCI L., AMHERDT M., RAVAZZOLA M., WIELAND F.T. and

J.E. ROTHMAN : En bloc incorporation of coatomer subunits during the assembly of COP-coated vesicles. J. Cell Biol. 124, 883-892 (1994).

422. ELAZAR Z., ORCI L., OSTERMANN J., AMHERDT M., TANIGAWA G. and J.E. ROTHMAN : ADP-ribosylation factor and coatomer couple fusion to vesicle budding. J. Cell Biol. 124, 415-424 (1994).

423. KUGE O., DASCHER C., ORCI L., ROWE T., AMHERDT M., PLUTNER H., RAVAZZOLA M., TANIGAWA G., ROTHMAN J.E. and W.E. BALCH : Sar1 promotes vesicle budding from the endoplasmic reticulum but not Golgi compartments. Sar1 regulation of ER export. J. Cell Biol. 125, 51-65 (1994).

424. PEPPER M.S., WASI S., FERRARA N., ORCI L. and R. MONTESANO : In vitro angiogenic and proteolytic properties of bovine lymphatic endothelial cells. Exp. Cell Res. 210, 298-305 (1994).

425. BARLOWE C., ORCI L., YEUNG T., HOSOBUCHI M., HAMAMOTO S., SALAMA N., REXACH M., RAVAZZOLA M., AMHERDT M. and R. SCHEKMAN : COPII: A membrane coat formed by Sec proteins that drives vesicle budding from the ER. Cell 77, 895-908 (1994).

426. CIRULLI V., BAETENS D., RUTISHAUSER U., HALBAN P.A., ORCI L. and D.G. ROUILLER : Expression of neural cell adhesion molecule (NCAM) in rat islets and its role in islet cell type segregation. J. Cell Sci. 107, 1429-1436 (1994).

427. ORCI L., HALBAN P., PERRELET A., AMHERDT M., RAVAZZOLA M. and R. ANDERSON : pH independent and dependent cleavage of proinsulin in the same secretory vesicle. J. Cell Biol. 126 1149-1156 (1994).

428. PEPPER M.S., VASSALLI J.-D., WILKS J.W., SCHWEIGERER L., ORCI L. and R. MON-TESANO : Modulation of microvascular endothelial cell proteolytic properties by inhibitors of angiogenesis. J. Cell Biochem. 55, 419-434 (1994).

429. HERRERA P.L., HARLAN D.M., FOSSATI L., IZUI S.,HUARTE J., ORCI L., VASSALLI J.-D. and P. VASSALLI : A CD8+ lymphocyte-mediated and CD4+ T lymphocyte-independent autoimmune diabetes of early onset in transgenic mice. Diabetologia 37, 1277-1279 (1994).

430. ORCI L., PERRELET A., RAVAZZOLA M., AMHERDT M., ROTHMAN J.E. and R. SCHEK-MAN : Coatomer-Rich Endoplasmic Reticulum. Proc. Natl. Acad. Sci USA 91, 11924-11928 (1994).

431. SANVITO F., HERRERA P.-L., HUARTE J., NICHOLS A., MONTESANO R., ORCI L. and J.-D. VASSALLI: TGF-β1 influences the relative development of the exocrine and endocrine pancreas in vitro. Development 120, 3451-3462 (1994).

432. HERRERA P.-L., HUARTE J., ZUFFEREY R., NICHOLS A., MERMILLOD B., PHILIPPE J., MUNIESA P., SANVITO F., ORCI L. and J.-D. VASSALLI : Ablation of islet endocrine cells by targeted expression of hormone-promoter-driven toxigenes. Proc. Natl. Acad. Sci (USA) 91,12999-13003 (1994).

433. SHAYWITZ D.A., ORCI L., RAVAZZOLA M., SWAROOP A. and C.-A. KAISER : Human SEC13Rp functions in yeast and is located on transport vesicles budding from the endoplasmic reticulum. J. Cell Biol. 128, 769-777 (1995)

Lelio ORCI Publications - Page 31 -434. PEPPER M.S., FERRARA N., ORCI L., and R. MONTESANO : Leukemia inhibitory factor

(LIF) inhibits angiogenesis in vitro. J. Cell Sci. 108, 73-83 (1995).

435. SORIANO J.V., PEPPER M.S., NAKAMURA T., ORCI L. and R. MONTESANO : Hepatocyte growth factor stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cells. J. Cell Sci. 108, 413-430 (1995).

436. GERICH B., ORCI L., TSCHOCHNER H., LOTTSPEICH F., RAVAZZOLA M., AMHERDT M., WIELAND F. and C. HARTER : Non-clathrin-coat protein α is a conserved subunit of coatomer and in Saccharomyces cerevisiae is essential for growth. Proc. Natl. Acad. Sci. USA 92, 3229-3233 (1995).

437. PEPPER M., SORIANO J., MENOUD P.A., SAPPINO A.P., ORCI L. and R. MONTESANO : Modulation of hepatocyte growth factor and c-met in the rat mammary gland during pregnancy, lactation, and involution. Exp. Cell Res. 219, 204-210 (1995).

438. SCHEKMAN R., BARLOWE C., BEDNAREK S., CAMPBELL J., DOERING T., DUDEN R., KUEHN M., REXACH M., YEUNG T. and L. ORCI : Coat proteins and selective protein packaging into transport vesicles. Cold Spring Harbor Symposia. Vol LX, 11-21 (1995).

439. BEDNAREK S.Y., RAVAZZOLA M., HOSOBUCHI M., AMHERDT M., PERRELET A., SCHEKMAN R. and L. ORCI : COP I- and COP II-coated vesicles bud directly from the endo-plasmic reticulum in yeast. Cell 83, 1183-1196 (1995).

440. SANVITO F., NICHOLS A., HERRERA P.-L., HUARTE J., WOHLWEND A., VASSALLI J.-D. and L. ORCI : TGF-β1 overexpression in murine pancreas induces chronic pancreatitis and together with TNF-α, triggers insulin-dependent diabetes. Biochem. Biophys. Res. Comm. 217, 1279-1286 (1995).

441. VOZZI C., ULLRICH S., CHAROLLAIS A., PHILIPPE J., ORCI L. and P. MEDA : Adequate connexin-mediated coupling is required for proper insulin production. J. Cell Biol. 131, 1561-1572 (1995).

442. ROTHMAN J.E. and L. ORCI : Budding vesicles in living cells. Sci. Am. 274, 70-75 (1996).

443. SCHEKMAN R. and L. ORCI : Coat proteins and vesicle budding. Science 271, 1526-1533 (1996).

444. RAVAZZOLA M., HALBAN P.-A. and L. ORCI : Inositol 1,4,5-triphosphate receptor subtype 3 in pancreatic islet cell secretory granules revisited. Proc. Natl. Acad. Sci. USA 93, 2745-2748 (1996).

445. SORIANO J., ORCI L. and MONTESANO R. : TGF-β1 induces morphogenesis of branching cords by cloned mammary epithelial cells at subpicomolar concentrations. Biochem. Biophys. Res. Com. 220, 879-885 (1996).

446. NAGAHAMA M., ORCI L., RAVAZZOLA M., AMHERDT M., LACOMIS L., TEMPST P., ROTHMAN J.E., and T.-H. SOLLNER : A v-SNARE implicated in intra-Golgi transport. J. Cell Biol. 133, 507-516 (1996).

447. MONTESANO R., KUMAR S., ORCI L., and M.-S. PEPPER : Synergistic effect of hyaluronan oligosaccharides and vascular endothelial growth factor on angiogenesis in vitro. Lab. Invest. 75, 249-262 (1996).

448. ORCI L., SCHEKMAN R., and A. PERRELET : Interleaflet clear space is reduced in the mem-brane of COP I and COP II-coated buds/vesicles. Proc. Natl. Acad. Sci. USA 93, 8968-8970 (1996).

Lelio ORCI Publications - Page 32 -449. FAULSTICH D., AUERBACH S., ORCI L., RAVAZZOLA M., WEGEHINGEL S., LOTTS-

PEICH F., STENBECK G., HARTER C., WIELAND F.-T., and H. TSCHOCHNER : Architecture of coatomer : molecular characterization of δ-COP and protein interactions within the complex. J. Cell Biol. 135, 53-61 (1996).

450. PACCAUD J.-P., REITH W., CARPENTIER J.-L., RAVAZZOLA M., AMHERDT M., SCHEK-MAN R., and L. ORCI : Cloning and functional characterization of mammalian homologues of the COPII component Sec23. Mol. Biol. Cell 7, 1535-1546 (1996).

451. SOHN K., ORCI L., RAVAZZOLA M., AMHERDT M., BREMSER M., LOTTSPEICH F., FIE-DLER K., HELMS B.-J. and F.-T. WIELAND : A major transmembrane protein of Golgi-derived COPI-coated vesicles involved in coatomer binding. J. Cell Biol. 135, 1239-1248 (1996).

452. GORDEN L.D., MANDRIOTA S.J., MONTESANO R., ORCI L. and M.S. PEPPER : Vascular endothelial growth factor is increased in devascularized rat islets of Langerhans in vitro. Trans-plantation 63, 436-443 (1997).

453. PAEK I., ORCI L., RAVAZZOLA M., ERDJUMENT-BROMAGE H., AMHERDT M., TEMPST P., SÖLLNER T. H. and J. E. ROTHMAN : ERS-24, a mammalian v-SNARE implicated in vesicle traffic between the endoplasmic reticulum and the Golgi. J. Cell Biol. 137, 1017-1028 (1997).

454. ORCI L., STAMNES M., RAVAZZOLA M., AMHERDT M., PERRELET A., SÖLLNER T. H. and J. E. ROTHMAN : Bidirectional transport by distinct populations of COP I-coated vesicles. Cell 90, 335-349 (1997).

455. FURUTA M., YANO H., ZHOU A., ROUILLÉ Y., HOLST J.J., CARROLL R., RAVAZZOLA M., ORCI L., FURUTA H. and D.F. STEINER : Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2. Proc. Natl. Acad. Sci. USA 94, 6646-6651 (1997).

456. MONTESANO R., SORIANO J. V., PEPPER M. S. and L. ORCI : Induction of epithelial branch-ing tubulogenesis in vitro. J. Cell. Physiol. 173, 152-161 (1997).

457. FURUTA M., CARROLL R., MARTIN S., SWIFT H.H., RAVAZZOLA M., ORCI L. and D.F. STEINER : Incomplete processing of proinsulin to insulin accompanied by elevation of Des-31,32 proinsulin intermediates in islets of mice lacking active PC2. J. Biol. Chem. 273, 3431-3437 (1998).

458. ORCI L., PERRELET A. and J.E. ROTHMAN : Vesicles on strings : Morphological evidence for processive transport within the Golgi stack. Proc. Natl. Acad. Sci (USA) 95, 2279-2283 (1998).

459. MATSUOKA K., ORCI L., AMHERDT M., BEDNAREK S.Y., HAMAMOTO S., SCHEKMAN R. and T. YEUNG : COPII-coated vesicle formation reconstituted with purified coat proteins and chemically defined liposomes. Cell 93, 263-275 (1998).

460. SORIANO J.V., PEPPER M.S., ORCI L. and R. MONTESANO : Roles of hepatocyte growth factor/scatter factor and transforming growth factor-β1 in mammary gland ductal morphogenesis. J. Mamm. Gland Biol. Neoplasia 3, 133-150 (1998).

461. HERRERA P.L., ORCI L. and J.-D. VASSALLI : Two transgenic approaches to define the cell lineages in endocrine pancreas development. Mol. Cell. Endocrinol. 140, 45-50 (1998).

462. MONTESANO R., SORIANO J. V., FIALKA I. and L. ORCI : Isolation of EpH4 mammary epithelial cell subpopulations which differ in their morphogenetic properties. In Vitro Cell. Dev. Biol. 34, 468-477 (1998).

Lelio ORCI Publications - Page 33 -463. SPANG A., MATSUOKA K., HAMAMOTO S., SCHEKMAN R. and L. ORCI : Coatomer,

Arf1p, and nucleotide are required to bud coat protein complex I-coated vesicles from large synthetic liposomes. Proc. Natl. Acad. Sci. (USA) 95, 11199-11204 (1998).

464. UNGER R., ZHOU Y.-T. and L. ORCI : Regulation of fatty acid homeostasis in cells: novel role of leptin. Proc. Natl. Acad. Sci. (USA) 96, 2327-2332 (1999).

465. MENTHA G., RUBBIA-BRANDT L. ORCI L., BECKER Ch., GIOSTRA E., MAJNO P., BOR-ISCH B., HADENGUE A. and P. MOREL : Traumatic neuroma with biliary duct obstruction after orthotopic liver transplantation. Transplantation 67, 177-179 (1999).

466. HERRERA P. L., FOSSATI L., IZUI S., HARLAN D., VASSALLI J.-D., ORCI L. and P. VAS-SALLI : Modulation of an early and lethal autoimmune diabetes in transgenic mice by IL-4 overexpression and treatment with anti-IFN-γ antibody. Transgenics 3, 97-106 (1999).

467. GOMMEL D., ORCI L., EMIG E.M., HANNAH M.J., RAVAZZOLA M., NICKEL W., HELMS J.B., WIELAND F.T. and K. SOHN: p24 and p23, the major transmembrane proteins of COPI-coated transport vesicles, form hetero-oligomeric complexes and cycle between the organelles of the early secretory pathway. FEBS Letters 447, 179-185 (1999).

468. PAGANO A., LETOURNEUR F., GARCIA-ESTEFANIA D., CARPENTIER J.-L., ORCI L. and J.-P. PACCAUD : Sec24 proteins and sorting at the endoplasmic reticulum. J. Biol. Chem. 274, 7833-7840 (1999).

469. SORIANO J. V., PEPPER M. S., TAUPENOT L., BADER M.-F., ORCI L., and R. MONTE-SANO : Chromogranin A alters ductal morphogenesis and increases deposition of basement membrane components by mammary epithelial cells in vitro. Biochem. Biophys. Res. Comm. 259, 563-568 (1999).

470. HIGA M., ZHOU Y.-T., RAVAZZOLA M., BAETENS D., ORCI L. and R. H. UNGER : Tro-glitazone prevents mitochondrial alterations, β cell destruction, and diabetes in obese prediabetic rats. Proc. Natl. Acad. Sci. (USA) 96, 11513-11518 (1999).

471. RIVERA V. M., WANG X., WARDWELL S., COURAGE N. L., VOLCHUK A., KEENAN T., HOLT D. A., GILMAN M., ORCI L., CERASOLI F., ROTHMAN J. E., and T. CLACKSON : Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum. Science 287, 826-830 (2000).

472. ZHOU Y.-T., GRAYBURN P., KARIM A., SHIMABUKURO M., HIGA M., BAETENS D., ORCI L. and R. H. UNGER : Lipotoxic heart disease in obese rats: implications for human obes-ity. Proc. Natl. Acad. Sci. (USA) 97, 1784-1789 (2000).

473. VOLCHUK A., AMHERDT M., RAVAZZOLA M., BRÛGER B., RIVERA V. M., CLACKSON T., PERRELET A., SÖLLNER T. H., ROTHMAN J. E. and L. ORCI : Megavesicles implicated in the rapid transport of intra-cisternal aggregates across the Golgi stack. Cell 102, 335-348 (2000).

474. ORCI L., RAVAZZOLA M., VOLCHUK A., ENGEL T., GMACHL M., AMHERDT M., PER-RELET A., SÖLLNER T. H. and J. E. ROTHMAN : Anterograde flow of cargo across the Golgi stack potentially mediated via bidirectional “percolating” COPI vesicles. Proc. Natl. Acad. Sci. (USA) 97, 10400-10405 (2000).

475. ORCI L., AMHERDT M., RAVAZZOLA M., PERRELET A. and J.E. ROTHMAN : Exclusion of Golgi residents from transport vesicles budding from Golgi cisternae in intact cells. J. Cell Biol. 150, 1263-1269 (2000).

Lelio ORCI Publications - Page 34 -476. SHIMONI Y., KURIHARA T., RAVAZZOLA M., AMHERDT M., ORCI L. and R. SCHEK-

MAN : Lst1p and Sec24p cooperate in sorting of the plasma membrane ATPase into COPII vesicles in saccharomyces cerevisiae. J. Cell Biol. 151, 973-984 (2000).

477. UNGER R.H. and L. ORCI : Lipotoxic diseases of nonadipose tissues in obesity. Int. J. Obesity. Supp. 4, S28-32 (2000).

478. UNGER R.H. and L. ORCI : Diseases of liporegulation : new perspective on obesity and related disorders. The Faseb J. 15, 312-321 (2001).

479. MANDRIOTA S.J., JUSSILA L., JELTSCH M., COMPAGNI A., BAETENS D., PREVO R., BANERJI S., HUARTE J., MONTESANO R., JACKSON D.G., ORCI L., ALITALO K., CHRISTOFORI G and M.S. PEPPER . Vascular endothelial growth factor-C-mediated lymphan-giogenesis promotes tumour metastasis. The Embo J. 20, 672-682 (2001)

480. ANTONNY B., MADDEN D., HAMAMOTO S., ORCI L. and R. SCHEKMAN : Dynamics of the COPII coat with GTP and stable analogues. Nature Cell Biology 3, 531-537 (2001).

481. FURUTA M., ZHOU A., WEBB G., CARROLL R., RAVAZZOLA M., ORCI L. and D.F. STEINER : Severe defect in proglucagon processing in Islet A-cells of prohormone convertase 2 null mice. J. Biol. Chem. 276, 27197-27202 (2001).

482. MATSUOKA K., SCHEKMAN R., ORCI L. and J. E. HEUSER : Surface structure of the CO-PII-coated vesicle. Proc. Natl. Acad. Sci. (USA) 98, 13705-13709 (2001).

483. ZHU X. , ORCI L. , CARROLL R. , NORRBOM C. , RAVAZZOLA M. and D.F. STEINER : Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3. Proc. Natl. Acad. Sci. (USA) 99, 10299-10304 (2002).

484. SUPEK F., MADDEN D.T., HAMAMOTO S., ORCI L. and R. SCHEKMAN : Sec 16p potentiates the action of COPII proteins to bud transport vesicles. J. Cell Biol. 158, 1029-1038 (2002).

485. COSSON P., AMHERDT M., ROTHMAN J.E. and L. ORCI: A resident Golgi protein is excluded from peri-Golgi vesicles in NRK cells. Proc. Natl. Acad. Sci. (USA) 99, 12831-12834 (2002).

486. ORCI L., RAVAZZOLA M., MACK G.J., BARLOWE C. and S. OTTE: Mammalian Erv46 lo-calizes to the endoplasmic reticulum-Golgi intermediate compartment and to cis-Golgi cisternae. Proc. Natl. Acad. Sci. (USA) 100, 4586-4591 (2003).

487. ANTONNY B., GOUNON P., SCHEKMAN R. and L. ORCI: Self-assembly of minimal COPII cages. EMBO Reports 4, 419-424 (2003).

488. MILLER E.A., BEILHARZ T.H., MALKUS P.N., LEE M.C.S., HAMAMOTO S., ORCI L. and R. SCHEKMAN : Multiple cargo binding sites on the COPII subunit Sec24p ensure capture of diverse membrane proteins into transport vesicles. Cell 114, 497-509 (2003).

489. VARLAMOV O., VOLCHUK A., RAHIMIAN V., DOEGE C.A., PAUMET F., ENG W.S., ARANGO N., PARLATI F., RAVAZZOLA M., ORCI L., SÖLLNER T.H. and J.E. ROTHMAN : i-SNAREs : inhibitory SNAREs that fine-tune the specificity of membrane fusion. J. Cell Biol. 164, 79-88 (2004).


490. ORCI L., COOK W.S., RAVAZZOLA M., WANG M.-Y., PARK B.-H., MONTESANO R., and R. UNGER : Rapid transformation of white adipocytes into fat-oxidizing machines. Proc. Natl. Acad. Sci. (USA) 101, 2058-2063 (2004).

491. VOLCHUK A., RAVAZZOLA M., PERRELET A., ENG W.S., DI LIBERTO M., VARLAM-OV O., FUKASAWA M., ENGEL T., SÖLLNER T.H., ROTHMAN J.E., ORCI L. : Counter-current distribution of two distinct SNARE complexes mediating transport within the Golgi stack. Mol. Biol. Cell 15, 1506-1518 (2004).

492. NISATO R., HARRISON J.A., BUSER R., ORCI L., RINSCH C., MONTESANO R., DUPRAZ P. and PEPPER M.S. : Generation and characterization of telomerase-transfected human lym-phatic endothelial cells with an extended life span. Am. J. Pathol. 165, 11-24 (2004).

493. FUTAI E., HAMAMOTO S., ORCI L. and SCHEKMAN R. : GTP/gdp exchange by Sec12p ena-bles COPPII vesicle bud formation on synthetic liposomes. Embo J. 23, 4286-4296 (2004).

494. LEE MC., MILLER E.A., GOLDBERG J., ORCI L. and SCHEKMAN R. : Bi directional protein transport between the ER and Golgi. Ann. Rev Cell Dev. Biol. 20, 87-123 (2004).

495. KIM J., HAMAMOTO S., RAVAZZOLA M., ORCI L. and R. SCHEKMAN : Uncoupled Pack-aging of Amyloid Precursor Protein and Presenilin 1 into Coat Protein Complex II Vesicles. J. Biol Chem. 280, 7758-7768 (2005). (JBC Papers in Press. Published on December 28, 2004 as manuscript M411091200).

496. Carrozzino F., Soulie P., Huber D., Mensi N., Orci L., Cano A., Feraille E. and R. Montesano : Inducible expression of Snail selectively increases paracellular ion permeability and differentially modulates tight junction proteins. Am. J. Physiol. Cell Physiol. 289, C1002-C1014 (2005).

497. Lee M.C., Orci L., Hamamoto S., Futai E., Ravazzola M. and R. Schekman : Sar1p N-terminal helix initiates membrane curvature and completes the fission of a COPII vesicle. Cell 122, 605-617 (2005).

498. Cosson P., Ravazzola M., Varlamov O., Sollner T.H., Di Liberto M., Volchuk A., Rothman J.E. and L. Orci : Dynamic transport of SNARE proteins in the Golgi apparatus. Proc. Nat. Acad. Sci. U S A. 102, 14647-14652 (2005).

499. Wang M.Y., Orci L., Ravazzola M. and R.H. Unger : Fat storage in adipocytes requires inactiva-tion of leptin’s paracrine activity: implications for treatment of human obesity. Proc. Natl. Acad. Sci. U S A. 102, 18011-18016 (2005).

500. Boyadjiev SA, Fromme JC, Ben J, Chong SS, Nauta C, Hur DJ, Zhang G, Hamamoto S, Schekman R, Ravazzola M, Orci L, Eyaid W : Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi traffick-ing. Nature Genetics. 38 1192-1197 (2006). Epub 2006 Sep 17.

501. Wang CW, Hamamoto S, Orci L, Schekman R : Exomer : A coat complex for transport of select membrane proteins from the trans-Golgi network to the plasma membrane in yeast. J Cell Biol. 174 873-883 (2006).

Lelio ORCI Publications - Page 36 -502. Park BA, Wang MY, Lee Y, Yu X, Ravazzola M, Orci L, Unger RH : Combined leptin actions on

adipose tissue and hypothalamus are required to deplete adipocytes fat in lean rats : implications for obesity treatment. J Biol Chem.281 (52), 40283-40291 (2006).

503. Lee Y., Ravazzola M., Park B.-H., Bashmakov Y.K., Orci L. and R.H. Unger : Metabolic mecha-nisms of failure of intraportally transplanted pancreatic β-cells in rats. Role of lipotoxicity and prevention by leptin. Diabetes 56, 2295-2301 (2007).

504. Szczepaniak L.S., Victor R.G., Orci L. and R.H. Unger : Forgotten but gone : the rediscovery of fatty heart, the most common unrecognized disease in America. Circ. Res. 101, 759-767 (2007).

505. Fromme J.C., Ravazzola M., Hamamoto S., Al-Bawi M., Eyaid W., Boyadjiev S.A., Cosson P., Schekman R. and L. Orci : The genetic basis of a craniofacial disease provides insight into COPII coat assembly. Dev. Cell 13, 623-634 (2007).

506. Fromme J.C., Orci L. and R. Schekman : Coordination of COPII vesicle trafficking by Sec23. Trends Cell Biol. 18, 330-336 (2008).

507. Wang M.Y., Grayburn P., Chen S., Ravazzola M., Orci L. and R.H. Unger : Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome. Proc. Natl. Acad. Sci. U S A. 105, 6139-6144 (2008).

508. Orci L., Ravazzola M., Le Coadic M., Shen W.-W., Demaurex N., and P. Cosson : STIM1-in-duced precortical and cortical subdomains of the endoplasmic reticulum.. Proc. Natl. Acad. Sci. U S A. 106, 19358-19362 (2009).

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1. ROUILLER Ch., PICTET R., NICOLESCU P. et L. ORCI : Les cellules réticulo-endothéliales du foie et l’espace de Disse. Revue Intern. Hépatologie 17, 827 (1967).

2. JUNOD A., ORCI L., FORSSMANN W.G. and Ch. ROUILLER : Lésions morphologiques et physiologiques dans le syndrome complexe des souris à piquants (Acomys cahirinus). Journées Ann. de Diabétologie, Hôtel-Dieu, Paris, 1968, 31-39.

3. FORSSMANN W.G., ORCI L. und Ch. ROUILLER : Glucagonbildende und andere endokrine Zellen im Magendarmepithel und ihre Ultrastruktur. 14 Symp. der Deutschen Gessellschaft für Endokrinologie, Heidelberg 1968. In : Nebenschilddrüse und endokrine Regulationen des Calciumstoffwechsels Spontan-Hypoglykämie. Glucagon Springer Verlag, Berlin, 1968, pp 251-256.

4. ORCI L., JUNOD A., PICTET R., RENOLD A.E. and Ch. ROUILLER : Granulolysis in the A cells of the pancreas in spontaneous and experimental diabetes. 4th Europ. Reg. Conf. on Electron Microscopy, Rome 1968. Ed. by D.S. Bocciarelli, Tipografia Poliglotta Vaticana II, 365-366 (1968).

5. ORCI L., FORSSMANN W.G., FORSSMANN W. and Ch. ROUILLER : Electron microscopy of the intestinal endocrine cells. Comparative study. 4th. Europ. Reg. Cong. on Electron Microscopy, Rome 1968. Ed. by D.S. Bocciarelli, Tipografia Poliglotta Vaticana II, 369-370 (1968).

6. ORCI L., PICTET R., FORSSMANN W.G., RENOLD A.E. and Ch. ROUILLER: Ultrastructural evidence for glucagon-producing A-cells in the gastrointestinal mucosa of the rat. Suppl. Proc. 6th Congress Intern. Diabetes Federation, Stockholm 1967. Exc. Med. 172S, 213-216 (1969).

7. ORCI L., FORSSMANN W.G. und Ch. ROUILLER : Zur Ultrastruktur der endokrinen Zellen im Epithel des Magendarmtraktes. Verh. Anat. Ges., Anat. Anz., Leipzig 125, 187-194 (1969).

8. FORSSMANN W.G., ORCI L., FORSSMANN W. and Ch. ROUILLER : On the problem of the gastrin-producing-cell. Int. Symposium, Erlangen July 1968. In : Non-Insulin- Producing Tumors of the Pancreas. L. Demling & R. Ottenjann Ed. Georg Thieme Verlag, Stuttgart, pp 82-85 (1969).

9. LAMBERT A.E., ORCI L., JEANRENAUD B., ROUILLER Ch. et A.E. RENOLD: Organoculture de pancréas foetal de rat : Etude morphologique et libération d›insuline «in vitro». Jr. Ann. Diabétologie, Hôtel-Dieu, Paris, 115-129 (1969).

10. ORCI L., STAUFFACHER W., BEAVEN D., LAMBERT A.E., RENOLD A.E. and Ch. ROUILLER : Ultrastructural events associated with the action of Tolbutamide and Glybenclamide on pancreatic B-cells in vivo and in vitro. III Capri Conférence. Acta Diabetologica Latina VI, suppl. I, 271-374 (1969).

11. LAMBERT A.E., ORCI L., KANAZAWA Y. and A.E. RENOLD : Biosynthesis and release of insulin in organ cultures of fetal rat pancreas. III Capri Conference. Acta Diabetologica Latina VI, suppl. I., 505-537 (1969).

12. FORSSMANN W.G. und L. ORCI : Zur Endokrinologie der Pylorusschleimhaut. I. Experimentelle Beeinflussung der Gastrin- Zelle. Symp. Dtsch. Ges. Endokrin. 15, 408-411 (1969).

13. PERRELET A., ORCI L. und W.G. FORSSMANN : Zur Endokrinologie der Pylorusschleimhaut. II. Einbau von 5-Hydroxytryptophan- H3 in die Enteroserotoninzellen. Symp. Dtsch. Ges. Endokrin. 15, 412-414 (1969).

14. LAMBERT A.E., ORCI L. and A.E. RENOLD : Some factors controlling differentiation and/or modulation of rat pancreatic islet cells. In : Advances in Metabolic Disorders, suppl. 1. Early Diabetes, pp 35-43 (1970).

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15. STAUFFACHER W., ORCI L., AMHERDT M., LAMBERT A.E., RENOLD A.E. et Ch. ROUILLER : Le diabète spontané chez l’animal. Considérations sur la pathogénèse du syndrome aigu et sur la morphologie des lésions du syndrome chronique. Path.-Biol. 18, 539-549 (1970).

16. ORCI L., RUFENER C., PICTET R., RENOLD A.E. and Ch. ROUILLER : Present state of the evidence for mixed endocrine and exocrine pancreatic cells in spiny mice. In : The Structure and Metabolism of the Pancreatic Islets. Ed. S. Falkmer, B. Hellman, and I.B. Täljedal, Pergamon Press, Oxford & New York. Wenner-Gren Symposium No 16, 1970, pp 37-52.

17. LAMBERT A.E., ORCI L., KANAZAWA Y., RENOLD A.E. and Ch. ROUILLER: Control of endocrine function in organ cultures of fetal rat pancreas. In : The Structure and Metabolism of the Pancreatic Islets. Ed. S. Falkmer, B. Hellman and I.B. Täljedal. Pergamon Press, Oxford & New York. Wenner-Gren Symposium No 16, 1970, pp 81-95.

18. ORCI L., RENOLD A.E. and Ch. ROUILLER : Intracellular «α-granulolysis" in α-cells of diabetic animals. In : The Structure and Metabolism of the Pancreatic Islets. Ed. S. Falkmer, B. Hellman and I.B. Täljedal, Pergamon Press, Oxford & New York. Wenner-Gren Symposium No 16, 1970, pp 109-114.

19. LAMBERT A.E., KANAZAWA Y., ORCI L. and G.M. GRODSKY : Properties of isolated B-granules in suspension. In : The Structure and Metabolism of the Pancreatic Islets. Ed. S. Falkmer, B. Hellman and I.B. Täljedal, Pergamon Press, Oxford & New York. Wenner-Gren Symposium No 16, 1970, pp 397-405.

20. RENOLD A.E., ORCI L., STAUFFACHER W., JUNOD A. and Ch. ROUILLER: Remarks on pancreatic B-cells in spontaneous and experimental diabetes in small laboratory rodents. In : The Structure and Metabolism of the Pancreatic Islets. Ed. S. Falkmer, B. Hellman and I.B. Täljedal, Pergamon Press, Oxford & New York. Wenner-Gren Symposium No 16, 1970, pp 497-513.

21. ORCI L., LAMBERT A., AMHERDT M., CAMERON D., KANAZAWA Y. and W. STAUFFACHER: The autonomous nervous system and the B-cell : metabolic and morphological observations made in spiny mice (Acomys cahirinus) and in cultured fetal pancreas. IV Capri Conference. Acta Diabetologica Latina VII, suppl. I, 184-228 (1970).

22. LAMBERT A.E., KANAZAWA Y., HALTER J.B., ORCI L., ROUILLER Ch. and A.E. RENOLD : Insulin release from fetal and newborn rat pancreas in vitro : Role of the adenyl cyclase system. IV Capri Conference. Acta Diabetologica Latina VII, Suppl. 1, 229-263 (1970).

23. MATTER A., ORCI L., KARNOVSKY M.J. and Ch. ROUILLER : Digestive events in the Kupffer cells of rat liver. 7e Congrès International de Microscopie Electronique, Grenoble III, 55-56 (1970).

24. ORCI L., MATTER A. and Ch. ROUILLER : A study on rat liver cells by means of the freeze-etch technique. 7e Congrès International de Microscopie Electronique, Grenoble III, 485-486 (1970).

25. AMHERDT M., ORCI L., STAUFFACHER W., RENOLD A.E. and Ch. ROUILLER : Morphological evidence suggestive of an impairment of insulin secretion in vivo in normoglycemic Spiny mice (Acomys cahirinus). 7e Congrès International de Microscopie Electronique, Grenoble III, 501-502 (1970).

26. JEANRENAUD B., TOUABI M., CUSHMAN S.W., ORCI L. et A.E. RENOLD : Métabolisme énergétique et pinocytose dans la cellule adipeuse isolée. Journées Ann. de Diabétologie, Hôtel-Dieu, Paris, 171-179 (1970).

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27. STAUFFACHER W., AMHERDT M. and L. ORCI : Zur Pathogenese des hyperglykämischen Syndroms : Untersuchungen an spontan hyperglykämischen, «diabetischen» Tieren. Verh. Deutsch. Gesellsch. innere Medizin, Münschen 76, 21-32 (1970).

28. ROUILLER Ch. and L. ORCI : The structure of juxta-glomerular complex. The Kidney 4, 1-80 (1971).

29. ORCI L., STAUFFACHER W., RENOLD A.E. and Ch. ROUILLER : The ultrastructural aspect of A-cells of non ketotic and ketotic diabetic animals. Indications for stimulation and inhibition of glucagon production. Proc. of Europ. Day on Glucagon, Padua, March 1970. In : Current Topics on Glucagon. CEDAM Padova, pp 15-30 (1971).

30. LAMBERT A.E., ORCI L., KANAZAWA Y., JEANRENAUD B. and A.E. RENOLD : Biochemical and morphological events associated with the development of fetal rat pancreas “in vivo” and “in vitro”: Effect of glucagon and of other agents. Proc. of Europ. Day on Glucagon, Padua, March 1970. In : Current Topics on Glucagon. CEDAM Padova, pp. 35-48 (1971).

31. STAUFFACHER W., ORCI L., CAMERON D.P., BURR I.M. and A.E. RENOLD : Spontaneous hyperglycemia and/or obesity in laboratory rodents : An example of the possible usefulness of animal disease models with both genetic and environmental components. Rec. Progr. Horm. Res. 27, 41-90 (1971).

32. STAUFFACHER W., BURR I., CAMERON D., AMHERDT M. and L. ORCI : Effects of nicotinamide and of nicotinic acid on the pancreas in experimental diabetes. In : Metabolic Effects of Nicotinic Acid and its Derivatives. K.F. Gey & L.A. Carlson eds., Hans Huber, Berne 1971. Proc. of a Workshop held in Flims, Switzerland, March 23-25, 1970. pp 939-954 (1971).

33. LAMBERT A.E., KANAZAWA Y., BURR I.M., ORCI L. and A.E. RENOLD : On the role of cyclic AMP in insulin release : I. Overall effects in cultured fetal rat pancreas. In : Cyclic AMP and Cell Function. Ann. of the N.Y. Acad. Sci. 185, pp 232-244 (1971).

34. RENOLD A.E., CAMERON D.P., AMHERDT M., STAUFFACHER W., MARLISS E., ORCI L. and Ch. ROUILLER : Endocrine-metabolic anomalies in rodents with hyperglycemic syndromes of hereditary and/or environmental origin. Int. Symp. Comm. 50th Anniv. Insulin “Impact of Insulin on Metabolic Pathways”, oct. 1971, Jerusalem, Israel, J. Med. Sci. 8, 189-206 (1972).

35. ORCI L., AMHERDT M., KANAZAWA Y., LAMBERT A.E. and W. STAUFFACHER : Morphologic events in insulin secreting cell. Colloque INSERM : “Hormones Pancréatiques, Hormones de l’Eau et des Electrolytes” Paris mai 1972, 15-40 (1972).

36. LAMBERT A.E., BLONDEL B., KANAZAWA Y., MARLISS E.B. and L. ORCI : Morphological and biochemical studies of pancreatic cells in monolayer culture. Colloque INSERM : “Hormones Pancréatiques, Hormones de l’Eau et des Electrolytes”, Paris mai 1972, 41-54 (1972).

37. RENOLD A.E., ORCI L. et A.E. LAMBERT : Physiologie de l’insulino-sécrétion. II. Interprétations supplémentaires. J. Ann. Diabétol. Hôtel-Dieu, Paris, 37-40 (1972).

38. CAMERON D.P., AMHERDT M., ORCI L., DE PEYER R. and W. STAUFFACHER : Biochemical and morphological studies of immunoreactive insulin secretion in spontaneous and acquired obesity and/or hyperglycemia in rodents. In : Nutrition and Diabetes Mellitus. VI Capri Conf. Acta Diabetol. Latina IX, suppl. 1, pp. 89-146 (1972).

39. STAUFFACHER W., ORCI L., MARLISS E. and D.P. CAMERON : Nutritional influences on hyperglycemic syndromes in laboratory rodents : suggested usefulness of an “underdeveloped” area of research. In : Nutrition and Diabetes Mellitus. VI Capri Conference, Acta Diabetol. Latina IX, suppl. 1, pp. 579-596 (1972).

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40. ORCI L. : Comments on the pancreatic beta-cell structure. Groupe de Contact “Pancréas”, Bruxelles, nov. 1971, 339-344 (1972).

41. LAMBERT A.E., HENQUIN J.C. and L. ORCI : Chlorpromazine in malignant insulinoma. Brit. Med. J. 3, (5828), 701 (1972).

42. MALAISSE W.J., MALAISSE-LAGAE F., VAN OBBERGHEN E., SOMERS G. and L. ORCI : The microtubular-microfilamentous system of the pancreatic B-cell. Proc. 4th Intern. Cong. Endocrinol. Washington 1972. In : Int. Congress Series no 273 “Endocrinology”, Excerpta Medica 1973, pp 282-287.

43. CAMERON D.P., AMHERDT M., LEUENBERGER P., ORCI L. and W. STAUFFACHER : Microvascular alterations in chronically streptozotocin-diabetic rats. In : Vascular and Neurological Changes in Early Diabetes, suppl. 2 to “Advances in Metabolic Disorders”, R.A. Camerini-Davalos and H.S. Cole eds., Academic Press 1973, pp 257-264.

44. RENOLD A.E., RABINOVITCH A., WOLLHEIM C.B., KIKUCHI M., GUTZEIT A.H., AMHERDT M., MALAISSE-LAGAE F. and L. ORCI : Spontaneous and experimental diabetic syndromes in animals. A Reevaluation of their usefulness for approaching the physiopathology of diabetes. 5th Claude Bernard Lecture of the Europ. Assoc. for the Study of Diabetes, July 1973. In : Diabetes, Proc. 8th Cong. Intern. Diabetes Fed. July 1973, ICS no 312, Excerpta Medica 1974, W.J. Malaisse, J. Pirart eds, pp 22-38.

45. LAMBERT A.E., HENQUIN J.C. and L. ORCI : Role of beta cell membrane in insulin secretion. In : Diabetes, Proc. 8th Cong. Intern. Diabetes Fed. July 1973, ICS no 312 Excerpta Medica 1974, W.J. Malaisse, J. Pirart eds, pp 79-94.

46. ORCI L., RAVAZZOLA M., AMHERDT M. and F. MALAISSE-LAGAE : The B-cell boundary. In : Diabetes, Proc. 8th Cong. Intern. Diabetes Fed. July 1973, ICS no 312, Excerpta Medica 1974, W.J. Malaisse, J. Pirart eds, pp 104-118.

47. LE MARCHAND Y., ASSIMACOPOULOS-JEANNET F., LOTEN E.G., SINGH A., ORCI L. et B. JEANRENAUD : Rôle du foie dans le métabolisme des hydrates de carbone et des lipides. Journées de Diabétologie de l’Hôtel-Dieu, Paris, 1974, 7-10.

48. JEANRENAUD B., LE MARCHAND Y., ASSIMACOPOULOS-JEANNET F., SINGH A., ORCI L. and Ch. ROUILLER : The microtubules and the release of lipoproteins or proteins by the liver. In : Comparative Biochemistry and Physiology of Transport, L. Bolis, K. Bloch, S.E. Luria and F. Lynen eds., North-Holland Publ. Co. 1974, pp 295-300.

49. HEINDEL J.J., ORCI L. and B. JEANRENAUD : Fat mobilization and its regulation by hormones and drugs in white adipose tissue. In : Pharmacology of Lipid Transport and Atherosclerotic Processes. Int. Encycl. of Pharmacol. and Therap. Section 24, vol. 1, chap. 6, E.J. Masoro ed., Pergamon Press 1975, pp 175-373.

50. MARLISS E.B., ORCI L., GIRARDIER L., SEYDOUX J., WOLLHEIM C.B. et D. PORTE : Système nerveux central et glycorégulation. Journées de Diabétologie de l’Hôtel-Dieu, Paris, 7-22 (1975).

51. ORCI L. and A. PERRELET : Freeze-Etch Histology. A comparison between thin sections and freeze-etch replicas. Springer Verlag 1975, 168.

52. MALAISSE W.J., MALAISSE-LAGAE F., VAN OBBERGHEN E., SOMERS G., DEVIS G., RAVAZZOLA M. and L. ORCI : Role of microtubules in the phasic pattern of insulin release. In : The Biology of Cytoplasmic Microtubules. Ann. N.Y. Acad. Sci. 253 (D. Soifer ed.) 1975, pp 630-684.

53. SASAKI H., RUBALCAVA B., SRIKANT C.B., BAETENS D., ORCI L. and R.H. UNGER : Gut glucagonoid (GLI) and gut glucagon. In : Gastro-Intestinal Hormones Proc. Int. Symp. on Gastrointestinal Hormones, Austin, Texas 1974, Univ. Texas Press, 1975, pp 519-528.

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54. MALAISSE W.J., HERCHUELZ A., LEVY J., SOMERS G., DEVIS G., RAVAZZOLA M., MALAISSE-LAGAE F. and L. ORCI : Insulin release and movements of calcium in pancreatic islets. In : Calcium Transport in Contraction and Secretion. Int. Symp., Bressanone 1975, (E. Carafoli, F. Clementi, W. Drabikowski and A. Margreth, eds), North Holland American Elsevier Publ. Co., 1975, pp 211-266.

55. ORCI L. : Structural aspects of islet cell membrane. In : Dilemmas in Diabetes, chap. IV (Proc. of Totts Gap Colloquium on Diabetes Mellitus, 1974) Adv. in Exp. Med. and Biol. 65 (S. Wolf and B. Bishop Berle eds), Plenum Press New York and London, 1975, pp 62-86.

56. MALAISSE W.J., LECLERCQ-MEYER V., VAN OBBERGHEN E., SOMERS G., DEVIS G., RAVAZZOLA M., MALAISSE-LAGAE F. and L. ORCI : The role of the microtubular-microfilamentous system in insulin and glucagon release by the endocrine pancreas. In : Microtubules and Microtubule Inhibitors. Proc. Int. Symp. Beerse, 1975, (M. Bergers and M. De Brabander eds), North Holland Publ. Co 1975, pp 143-152.

57. LE MARCHAND Y., SINGH A., PATZELT C., ORCI L. and B. JEANRENAUD : In vivo and in vitro evidence for a role of microtubules in the secretory processes of liver. In : Microtubules and Microtubule Inhibitors. Proc. Int. Symp. Beerse, 1975, (M. Bergers and M. De Branbander eds) North Holland Publ. Co. 1975, pp 153-164.

58. RENOLD A.E., RABINOVITCH A., KIKUCHI M., GUTZEIT A.H., AMHERDT M. and L. ORCI : Relationship between obesity and spontaneous inappropriate hyperglycemia (diabetes) in animals. In : Obesity in Perspective. Fogarty International Center Series on Preventive Medicine vol. 2, part 2, (G.A. Bray ed.) U.S. Government Office Washington 1975, pp 289-294.

59. HEINDEL J.J., ORCI L. and B. JEANRENAUD : Fat mobilization and its regulation by hormones and drugs in white adipose tissue. Internat. Encyclop. Pharmac. Therapeutic : Section 24 Volume 1, pp 175-373 (1975).

60. MONTESANO R., GABBIANI G., FRIEND D.S., PERRELET A. and L. ORCI : In vivo modulation of tight junctions in the liver. In : The Liver, Quantitative Aspects of Structure and Function. 2nd Int. Gstaad Symp. Gstaad 1975, (R. Preisig, J. Bircher, G. Paumgartner eds) 1976, pp 62-69.

61. ORCI L. : Membrane topology as revealed by the binding of macromolecules. In: Polypeptides Hormones : Molecular and Cellular Aspects. Ciba Foundation Symposium 41, Elsevier Excerpta Medica 1976, pp 267-277, Discussion pp 277-280.

62. ORCI L. : Cell containing somatostatin in the pancreas and the gastrointestinal tract. General Discussion I : Somatostatin - Clinical Implications. In Polypeptide Hormones : Molecular and Cellular Aspects. Ciba Foundation Symposium 41, Elsevier Excerpta Medica 1976, pp 313-350.

63. LAMBERT A.E., ORCI L. and A.E. RENOLD : Tissue culture of endocrine rat pancreas : A model for studies of the secretory function of the beta cell. In : Organ Culture in Biomedical Research, British Society for Cell Biology Symposium 1. M. Balls and M. Monnickendam, eds. Cambridge Univ. Press 1976, pp 257-277.

64. ORCI L. : Some aspects of the morphology of insulin-secreting cells. Acta Histochem. 55, 147-158 (1976).

65. MALAISSE W.J., DEVIS G., SOMERS G., VAN OBBERGHEN E., MALAISSE-LAGAE F., RAVAZZOLA M., BLONDEL B. and L. ORCI : The role of microtubules and microfilaments in secretion. In : Stimulus-Secretion Coupling in the Gastro-Intestinal Tract. Proc. Int. Conf. Titisee, 1975. R.M. Case & H. Goebell, eds. MTP Press Ltd 1976, pp 65-76 (Discussion pp. 77-78).

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66. UNGER R.H. and L. ORCI : Physiology and pathophysiology of glucagon. Physiol. Rev. 56, 778-826 (1976).

67. ORCI L. and A. PERRELET : Ultrastructural identification of receptors and binding sites at the cell surface. In : The Effects of Environment on Cells and Tissues. Excerpta Medica ICS no 384. Proc. IX World Congress of Anatomic and Clinical Pathology, Sydney, 1975, Amsterdam, 1976, pp 95-109.

68. ORCI L., BAETENS D., RAVAZZOLA M., MALAISSE-LAGAE F., AMHERDT M. and C. RUFENER : Somatostatin in the pancreas and the gastrointestinal tract. In : Endocrine Gut and Pancreas. T. Fujita ed. Elsevier Sci. Publ. Co., Amsterdam, 1976, pp 73-88.

69. ORCI L. and A. PERRELET : Islet cell membrane perturbation during exocytosis. In : Endocrine Gut and Pancreas. T. Fujita ed. Elsevier Sci. Publ. Co, Amsterdam, 1976, pp 295-299.

70. MALAISSE-LAGAE F., RAVAZZOLA M., ROBBERECHT P., VANDERMEERS A., MALAISSE W.J. and L. ORCI : Hydrolases content in peri-insular and tele-insular exocrine pancreas. In : Endocrine Gut and Pancreas. T. Fujita, ed. Elsevier Sci. Publ. Co., Amsterdam, 1976, pp 314-320.

71. ORCI L. : A fresh look at the interrelationships within the islets of Langerhans. In : Diabetes Research Today. Symposia Medica Hoechst 12, Schattauer Verlag, Stuttgart, 1976, pp 135-151.

72. MORRISON A.D., ORCI L., BERWICK L. and A.I. WINEGRAD : A new look at the metabolism of the arterial wall. Trans. Assoc. Am. Physicians 89, 237-244 (1976).

73. STAUFFACHER W., KIKKAWA R., AMHERDT M. and L. ORCI : Hereditary hyperglycemic syndromes in laboratory rodents. In: The Genetics of Diabetes Mellitus. W. Creutzfeldt, J. Köbberling, J.V. Neel, eds. Springer-Verlag, Berlin-Heidelberg, 1976, chap. 17, pp 155-164.

74. UNGER R.H. and L. ORCI : The role of glucagon in the endogenous hyperglycemia of diabetes mellitus. Ann. Rev. Med. 28, 119-130 (1977).

75. MORRISON A.D., ORCI L., BERWICK L. and A.I. WINEGRAD : Significance of an intact endothelium with regard to the metabolism of aortic intima-media preparations. In : The Biochemistry of Smooth Muscle. N.L. Stephens ed. Univ. Park Press, Baltimore, Md. USA 1977, pp 83-103.

76. ORCI L. : Morphologic events underlying the secretion of peptide hormones. In : Endocrinology, vol. 2, V.H.T. James ed. Excerpta Medica Amsterdam, 1977, pp 7-40.

77. MALAISSE W.J., MALAISSE-LAGAE F., AMHERDT M., RAVAZZOLA M. and L. ORCI : Role of microtubules in hormone synthesis. In : Endocrinology, vol. 2, V.H.T. James, ed. Excerpta Medica Amsterdam, 1977, pp 61-64.

78. ORCI L. : The islet of Langerhans : A multihormonal micro-organ. In : Insulin and Metabolism, ed. J.S. Bajaj, Excerpta Medica, Amsterdam, 1977, chap. 1, pp. 1-11.

79. UNGER R.H. and L. ORCI : Role of glucagon in diabetes. Arch. Intern. Med. 137, 482-491 (1977).

80. ORCI L., AMHERDT M., BAETENS D., MALAISSE-LAGAE F., RAVAZZOLA M. and C. RUFENER : Immunocytochemistry of pancreatic endocrine cells in vitro and in situ. In : Pancreatic Beta Cell Culture. Excerpta Medica. ICS no 408, E. v. Wasielewski, W.I. Chick, eds. Amsterdam, 1977, pp 9-22.

81. ORCI L. and A. PERRELET : Morphology of membrane systems in pancreatic islets. In : The Diabetic Pancreas, chap. 7. B.W. Volk & K.F. Wellmann eds. Plenum Press, New York, 1977, pp 171-210.

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82. UNGER R.H., RASKIN P., SRIKANT C.B. and L. ORCI : Glucagon and the A-cells. In : Recent Progress in Hormone Research vol. 33, R.O. Greep ed. Acad. Press, New York, 1977, pp 477-517.

83. Contribution to the Discussion to : FLOYD J.C. Jr., FAJANS S.S., PEK S. and R.E. CHANCE : A newly recognized pancreatic polypeptide; plasma levels in health and disease. In : Recent Progress in Hormone Research, vol. 33, R.O. Greep ed. Acad. Press, New York, 1977, pp. 519-556, discussion pp 565-570.

84. ORCI L. : Ultrastruktur und Funktion der Insulinproduzierenden Zellen. In : Struktur und Funktion der Langerhansschen Insel. Erg. exp. Med. 26, pp 9-11 (1977).

85. CARPENTIER J.-L., MALAISSE-LAGAE F., MULLER W. and L. ORCI : Morphologic study of glucagon release. In : Glucagon : Its Role in Physiology and Clinical Medicine. Eds. P.P. Foà, J.S. Bajaj and N.L. Foà, Springer Verlag, New York, 1977, pp 23-30.

86. MOODY A.J., JACOBSEN H., SUNDBY F., FRANDSEN E.K., BAETENS D. and L. ORCI : Heterogeneity of gut glucagon-like immunoreactivity (GLI). In : Glucagon : Its Role in Physiology and Clinical Medicine, Eds. P.P. Foà, J.S. Bajaj and N.L. Foà, Springer Verlag, New York, 1977, pp 129-135.

87. UNGER R.H., DOBBS R.E. and L. ORCI : Insulin, glucagon and somatostatin secretion in the regulation of metabolism. Ann. Rev. Physiol. 40, 307-343 (1978).

88. ORCI L. and A. PERRELET : Ultrastructural aspects of exocytotic membrane fusion. In : Cell Surface Reviews, vol. 5 : Membrane Fusion, chap. 12, G. Poste & G.L. Nicolson, eds. North Holland, New York, 1978, pp 629-656.

89. MORRISON A.D., ORCI L., BERWICK L., PERRELET A. and A.I. WINEGRAD : The status of the arterial endothelium in experimental studies. In : Atherosclerosis Reviews, vol. 3, R. Paoletti and A.M. Gotto, Jr. eds. Raven Press, New York, 1978, pp 125-132.

90. MALAISSE W.J., SENER A., HERCHUELZ A., HUTTON J.C., DEVIS G., SOMERS G., BLONDEL B., MALAISSE-LAGAE F. and L. ORCI : Sequential events in the process of glucose-induced insulin release. In : Diabetes. ICS no 413, Excerpta Medica, Amsterdam, 1978, pp 95-102.

91. PATEL Y.C., CAMERON D.P., MALAISSE-LAGAE F. and L. ORCI : Changes in pancreatic somatostatin concentration in diabetes. In : Diabetes. ICS no 413, Excerpta Medica, Amsterdam, 1978, pp 43-50.

92. ORCI L., MALAISSE-LAGAE F., BAETENS D. and A. PERRELET : Pancreatic-polypeptide-rich regions in human pancreas. The Lancet II, 1200-1201 (1978).

93. ORCI L., PERRELET A. and P. GORDEN : Less-understood aspects of the morphology of insulin secretion and binding. Proc. of the 1977 Laurentian Hormone Conference. Rec. Progr. Horm. Res. 34, 95-121 (1978).

94. MALAISSE W.J. and L. ORCI : The role of the cytoskeleton in pancreatic B-cell function. In : Meth. Achiev. exp. Pathol. vol. 9. Cell Physiopathology, Karger, Basel, 1979, pp 112-136.

95. MALAISSE-LAGAE F., ORCI L. and A. PERRELET : Anatomic and hormonal markers for the ventral primordium in the human pancreas ? The New England Journal of Medicine 300, 436 (1979).

96. ORCI L., STEFAN Y., MALAISSE-LAGAE F. and A. PERRELET : Instability of pancreatic endocrine cell populations throughout life. The Lancet I, 615-616 (1979).

97. MALAISSE W.J., SOMERS G., DEVIS G., BLONDEL B., MALAISSE-LAGAE F. and L. ORCI : Microfilamentous-microtubular system, motile events and insulin release in the pancreatic B-cell. In : Protides of the Biological Fluids. Proc. of the 26 Colloquium, 1978. H. Peeters, ed., Pergamon Press, Oxford and New York, 1979, pp 585-590.

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98. ORCI L. and A. PERRELET : The islet of Langerhans revisited with immunofluorescence and freeze-fracture. Spectrum Intern. XXII, no 2, 17-23 (1979).

99. ORCI L. and A. PERRELET : L’îlot de Langerhans revu en immunofluorescence et en cryodécapage. Spectrum Intern. XXII, no 2, 1-8 (1979).

100. ORCI L. and A. PERRELET : Het eilandje van Langerhans herontdekt met immunofluorescentie en criesfractie. Spectrum Intern. XXII, no 2, 1-8 (1979).

101. ORCI L. and A. PERRELET : Wyspy Langerhansa - Nowe podlady oparte na badaniach immunofluorescencyjnych i metoda zamrozeniowa z lamaniem/freeze-fracture. Spectrum Intern. XXII, no 2, 17-23 (1979).

102. ORCI L. and A. PERRELET : La microarchitecture des îlots de Langerhans. Pour la Science no 22, 30-44 (1979).

103. UNGER R.H. and L. ORCI : Glucagon : Secretion, Transport, Metabolism, Physiologic Regulation of Secretion, and Derangements in Diabetes. In : Endocrinology vol. 2, 1979, ed. L.J. DeGroot et al. Grune & Stratton, New York, pp 959-980.

104. ORCI L., STEFAN Y., MALAISSE-LAGAE F., PERRELET A. and Y. PATEL : Pancreatic fat. New Engl. J. Med. 301, 1292 (1979).

105. CARPENTIER J.-L., GORDEN P., FREYCHET P. and L. ORCI : Binding, internalization and lysosomal degradation of 125I-insulin in isolated rat hepatocytes. In : Diabetes 1979, ed. W.K. Waldhäusl. Excerpta Medica ICS 500, Amsterdam, 1980, pp 203-208.

106. MEDA P., AMHERDT M., PERRELET A. and L. ORCI : Coupling between insulin-containing cells. A morphological approach. In : Diabetes 1979, ed. W.K. Waldhäusl. Excerpta Medica ICS 500, Amsterdam, 1980, pp 496-501.

107. ROTH J., BENDAYAN M. and L. ORCI : FITC-protein A-gold complex for light and electron microscopic immunocytochemistry. J. Histochem. Cytochem. 28, 55-57 (1980).

108. ROTH J., BENDAYAN M. and L. ORCI : Protein A-gold complex for postembedding staining of intracellular antigens. Acta histochemica, Suppl.-Band XXII, 269-273 (1980).

109. GORDEN P., CARPENTIER J.-L., FREYCHET P. and L. ORCI : Internalization of polypeptide hormones. Mechanism, intracellular localization and significance. Diabetologia 18, 263-274 (1980).

110. CARPENTIER J.-L., GORDEN P., FREYCHET P. et L. ORCI : Aspects morphologiques de l’interaction de l’insuline avec sa cellule cible. Journées Annuelles de Diabétologie de l’Hôtel-Dieu 1980, 276-282.

111. ORCI L. : Some recent findings concerning the rodent and human endocrine pancreas. In : “Current Views on Hypoglycemia and Glucagon”, D. Andreani, P.J. Lefebvre & V. Marks eds. Proc. of the Serono Symposia vol. 30, Academic Press 1980, pp 1-11.

112. CARPENTIER J.-L., MALAISSE-LAGAE F., MULLER W.A. and L. ORCI : Morphology of glucagon release in vitro : An unsettled controversy. In : “Current Views on Hypoglycemia and Glucagon”. D. Andreani, P.J. Lefebvre & V. Marks eds. Proc. of the Serono Symposia vol. 30, Academic Press 1980, pp 13-20.

113. UNGER R.H. and L. ORCI : Alpha cell function in diabetes mellitus. In : “Current Views on Hypoglycemia and Glucagon”, D. Andreani, P.J. Lefebvre & V. Marks eds. Proc. of the Serono Symposia vol. 30, Academic Press 1980, pp 93-105.

114. BORDI C., RAVAZZOLA M. and L. ORCI : Glicentin in glucagonomas. In : Current Views on Hypoglycemia and Glucagon”, D. Andreani, P.J. Lefebvre & V. Marks eds. Proc. of the Serono Symposia vol. 30, Academic Press 1980, pp 137-139.

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115. GORDEN P., CARPENTIER J.-L., FREYCHET P. and L. ORCI : Morphologic probes of polypeptide hormone receptor interactions. J. Histochem. Cytochem. 28, 811-817 (1980).

116. MEDA P., PERRELET A. and L. ORCI : Gap junctions and B-cell junction. Horm. Metab. Res. Suppl. Series vol. no 10, 157-162 (1980).

117. UNGER R.H., ROUILLER D. and L. ORCI : Control of fuel fluxes by polypeptides. In : “Peptides : Integrators of Cell and Tissue Function”. (Ed. F.E. Bloom), Raven Press, New York, 1980, vol. 35, pp 69-79.

118. GORDEN P., CARPENTIER J.-L., FREYCHET P., ROTH J. and L. ORCI : Consequences and mechanisms of insulin receptor regulation. In: Endocrinology 1980. I.A. Cumming, J.W. Funder and F.A.O. Mendelsohn eds. Elsevier/North-Holland Biomedical Press, pp 591-594.

119. ORCI L., CARPENTIER J.-L. and P. GORDEN : Binding and internalization of polypeptide hormones. In : Gut Hormones, 2nd edition. S.R. Bloom and J.M. Polak eds. Churchill Livingstone, Edinburgh, 1981, pp 144-149.

120. UNGER R.H. and L. ORCI (EDITORS) : Glucagon. Physiology, Pathophysiology, and Morphology of the pancreatic A-cells. Elsevier North Holland, Biomedical Press, 1981, 1-452.

121. ORCI L. and A. PERRELET : The morphology of the A-cell. In : Glucagon. Physiology, Pathophysiology, and Morphology of the Pancreatic A-cells. (Part I : Morphology). R.H. Unger & L. Orci, eds. Elsevier North Holland, Biomedical Press, 1981, pp 3-36.

122. UNGER R.H. and L. ORCI : Control of glucagon secretion : Within-islet controls. In : Glucagon. Physiology, Pathophysiology and Morphology of the Pancreatic A-cells. (Part III : Control of Glucagon Secretion). R.H. Unger & L. Orci, eds. Elsevier North Holland, Biomedical Press, 1981, pp 161-169.

123. UNGER R.H. and L. ORCI : Glucagon Physiology : Heterogeneity of polypeptide functions and routes of transmission. In : Glucagon. Physiology, Pathophysiology and Morphology of the Pancreatic A-cells. (Part IV : The physiology of Glucagon). R.H. Unger & L. Orci, eds. Elsevier North Holland, Biomedical Press, 1981, pp 173-175.

124. UNGER R.H. and L. ORCI : Diabetes : Morphofunctional relationships of the A-cells. In : Glucagon. Physiology, Pathophysiology and Morphology of the Pancreatic A-cells. (Part VI : A-Cell Disorders). R.H. Unger & L. Orci, eds. Elsevier North Holland, Biomedical Press, 1981, pp 361-368.

125. UNGER R.H. and L. ORCI : Glucagon in the pathogenesis of diabetes mellitus : the bihormonal abnormality hypothesis. In : Glucagon. Physiology, Pathophysiology and Morphology of the Pancreatic A-cells. (Part VI : A-Cell Disorders). R.H. Unger & L. Orci, eds. Elsevier North Holland, Biomedical Press, 1981, pp 369-376.

126. BORDI C., RAVAZZOLA M. and L. ORCI : The morphology of glucagonomas. In : Glucagon. Physiology, Pathophysiology and Morphology of the Pancreatic A-cells. (Part VI : A-Cell Disorders). R.H. Unger & L. Orci, eds. Elsevier North Holland, Biomedical Press, 1981, pp 399-411.

127. UNGER R.H. and L. ORCI : Glucagon and the A cell. Physiology and Pathophysiology. (First of Two Parts). New Engl. J. Med. 304, 1518-1524 (1981).

128. UNGER R.H. and L. ORCI : Glucagon and the A cell. Physiology and Pathophysiology. (Second of Two Parts). New Engl. J. Med. 304, 1575-1580 (1981).

129. ORCI L., STEFAN Y., BONNER-WEIR S., PERRELET A. and R. UNGER : “Obligatory” association between A- and D-cells demonstrated by bipolar islets in neonatal pancreas. Diabetologia 21, 73-74 (1981).

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130. GORDEN P., CARPENTIER J.-L. and L. ORCI : Morphologic and biochemical events in the interaction of polypeptide hormones with target cells. In: Receptor-Mediated Binding and Internalization of Toxins and Hormones. J.L. Middlebrook and L.D. Kohn (eds). Academic Press New York, 1981, pp 251-257.

131. ORCI L. : Membrane cycling in secretion. A morphological approach. In : Current Topics in Cellular Regulation 18. Biological Cycles. R.W. Estabrook and P. Srere (eds.). Academic Press, New York, 1981, pp 531-550.

132. ORCI L. et A. PERRELET : L’îlot de Langerhans. Revu en immunofluorescence et en cryodécapage. Propos sur le Diabète (Pfizer) 29, 3-8 (1981).

133. ORCI L., HUMBERT F., BROWN D. and A. PERRELET : Membrane ultrastructure in urinary tubules. In : Int. Rev. Cytol. 73, pp 183-242 (1981).

134. ORCI L., MONTESANO R. and A. PERRELET : Exocytosis-endocytosis as seen with morphological probes of membrane organization. In : Methods in Cell Biology 23, Basic Mechanisms of Cellular Secretion. A.R. Hand and C. Oliver, eds. Academic Press, New York, 1981, pp 283-300.

135. ORCI L., AMHERDT M., MONTESANO R., VASSALLI P. and A. PERRELET : Topology of morphologically detectable protein and cholesterol in membranes of polypeptide-secreting cells. In : The Control of Secretion. The Royal Society. Phil. Trans. R. Soc. Lond. B. 296, 1981, pp 47-54.

136. UNGER R.H. and L. ORCI : The role of glucagon in diabetes. Comprehensive Therapy 8, 53-59 (1982).

137. ORCI L. : Macro- and micro-domains in the endocrine pancreas. Banting Lecture 1981. Diabetes 31, 538-565 (1982).

138. GORDEN P., CARPENTIER J.-L., FAN J.Y. and L. ORCI : Receptor mediated endocytosis of polypeptide hormones : Mechanism and significance. Metabolism 31, 664-669 (1982).

139. ROTH J., THORENS B., BROWN D., BAETENS D., GARCIA-SEGURA L.M., NORMAN A.W. and L. ORCI : Immunocytochemical localization of vitamin D-dependent calcium binding protein (CaBP) in duodenum, kidney, brain and pancreas. In : Vitamin D, Chemical, Biochemical and Clinical Endocrinology of Calcium Metabolism. A.W. Norman, K. Schaefer, D.v. Herrath, H.-G. Grigoleit, eds. Walter de Gruyter & Co., 1982, pp 209-214.

140. MEDA P., PERRELET A. and L. ORCI : Endocrine cell interactions in the islets of Langerhans. In : Functional Integration of Cells in Animal Tissues. (J.D. Pitts and M.E. Finbow, eds). Cambridge University Press 1982, pp 113-131.

141. NORMAN A.W., ROTH J. and L. ORCI : The vitamin D endocrine system : steroid metabolism, hormone receptors, and biological response (calcium binding proteins). Endocrine Reviews 3, 331-366 (1982).

142. ORCI L., BORDI C., UNGER R.H. and A. PERRELET : Glucagon- and glicentin-producing cells. In : Handbook of Experimental Pharmacology. (P.J. Lefèbvre ed.). Springer Verlag. Vol. 66/I, 1983, pp 57-79.

143. HIZUKA N., GORDEN P., CARPENTIER J.-L., LESNIAK M.A., ORCI L. and K. SHIZUME : Internalization of human growth hormone (hGH). Proc. of the International Symposium of the Hormone Receptors and Receptor Diseases, 1982. H. Imura and H. Kuzuya eds. Excerpta Medica ICS 603, 1983, 45-52.

144. UNGER R.H. and L. ORCI : Glucagon in diabetes mellitus. In : Handbook of Experimental Pharmacology. (P.J. Lefèbvre, ed.). Springer Verlag. Vol. 66/II, 1983, pp 431-450.

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145. FEHLMANN M., CARPENTIER J.-L., VAN OBBERGHEN E., BRANDENBURG D., ORCI L. and P. FREYCHET : Internalization and recycling of insulin receptors in rat hepatocytes. In : Hormones and Cell Regulation 7. J.E. Dumont, J. Nunez and R. Denton eds. Elsevier Biomedical Press, 1983, pp 59-71.

146. ORCI L. : Cellular relationships in the islet of Langerhans : A regulatory perspective. In : The Importance of Islets of Langerhans for Modern Endocrinology (K.F. Federlin and J. Scholtholt, eds.). Raven Press, New York, 1984, pp 11-26.

147. ORCI L. : Patterns of cellular and subcellular organization in the endocrine pancreas. The Sir Henry Dale Lecture for 1983. J. Endocr. 102, 3-11 (1984).

148. MEDA P., PERRELET A. and L. ORCI : Gap junctions and cell-to-cell coupling in endocrine glands. In : Modern Cell Biology 3, 1984, pp 131-196.

149. MEDA P., ATWATER I., GONCALVES A., BANGHAM A., ORCI L. and E. ROJAS : The topography of electrical synchrony among β-cells in the mouse islet of Langerhans. Quat. J. Exp. Physiol. 69, 719-735 (1984).

150. CARPENTIER J.-L., FEHLMANN M., VAN OBBERGHEN E., GORDEN P. and L. ORCI : Morphological aspects and physiological relevance of insulin receptor internalization and recycling. Proc. 7th Cong. of Endocrinol. In : Endocrinology (F. Labrie and L. Proulx eds.) ICS 655, 1984, pp 349-353.

151. ORCI L. and A. PERRELET : Morphology of membrane systems in pancreatic islets. In : The Diabetic Pancreas. 2nd Edition. B.W. Volk and E.R. Arquilla eds. Plenum Publ. Corp., New York, 1985, pp 171-212.

152. ORCI L. : Organizzazione cellulare e subcellulare nel pancreas endocrino. IX Conferenza Annuale Lorenzini. Rassegna Clinico Scientifica, Anno LXI, N. 3-4, 50-66 (1985).

153. ORCI L. : The insulin factory : a tour of the plant surroundings and a visit to the assembly line. The Minkowski lecture 1973 revisited. Diabetologia 28, 528-546 (1985).

154. GORDEN P., CARPENTIER J.-L. and L. ORCI : Insulin action at the cellular level : Anatomical considerations. Diabetes/Metabolism Reviews 1, 99-117 (1985).

155. ORCI L. and E.L. BEARER : Rose windows. Diabetes Forecast January-February 1986, 31-33.

156. CARPENTIER J.-L., GORDEN P. and L. ORCI : Insulin interaction with target cells. Morphofunctional aspects. In : Receptor-Mediated Uptake in the Liver. H. Greten, E. Windler, and U. Beisiegel eds. Springer Verlag, 1986, pp 145-153.

157. CARPENTIER J.-L., GORDEN P., ROBERT A. and L. ORCI : Internalization of polypeptide hormones and receptor recycling. Experientia 42, 734-744 (1986).

158. ORCI L. : The insulin cell : Its cellular environment and how it processes (pro)insulin. Diabetes/Metabolism Reviews 2, 71-106 (1986).

159. SANTANGELO W.C., UNGER R.H., ORCI L. DUENO M.I., POPMA J.J. and G.J. KREJS : Somatostatin analog-induced remission of necrolytic migratory erythema without changes in plasma glucagon concentration. In : Pancreas 1, Raven Press, New York, 1986, pp 464-469.

160. ORCI L. : The Morphology of proinsulin processing. In : “Membrane Pathology”. Annals of the New York Academy of Sciences 488. G. Bianchi, E. Carafoli, A. Scarpa, eds. New York, 1987, pp 292-316.

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161. MOORE H.-P. H., ORCI L. and G.F. OSTER : Biogenesis of secretory vesicles. In : «Protein Transfer and Organelle Biogenesis». R.C. Das & P.W. Robbins, eds. Academic Press 1988, pp 521-561.

162. ORCI L., VASSALLI J.-D. and A. PERRELET : The insulin factory. Scientific American, 256, Sept. 1988, 85-94.

163. ORCI L. : Proinsulin conversion site. In : “Molecular Biology of Brain and Endocrine Pepti-dergic Systems”. M. Chrétien, ed. Raven Press, New York, 1988, pp 103-122.

164. ORCI L. : The cell biology of proinsulin processing. In : “Pathogenesis of Non-Insulin Dependent Diabetes Mellitus”. V. Grill & S. Efendic, eds. Raven Press, New York, 1988, pp 1-26.

165. UNGER R.H. and L. ORCI : Glucagon secretion and metabolism in man. In : Pancreas. 2nd Edition. De Groot L.J. ed. Chap. 78, W.B. Saunders Company, Philadelphia, 1989, pp 1318-1332.

166. ORCI L. : What a book on cell ultrastructure should not be. (Book Review). Cell 58, 813 (1989).

167. KOMIYA I., BAETENS D., INMAN L., PERRELET A., ORCI L. and R.H. UNGER : Morphometric and functional studies of islets in diabetes-prone BB/W rats that are discordant for overt diabetes. Diab. Nutr. Metab. 2, 263-267 (1989).

168. MELANCON P., GLICK B.S., MALHOTRA V., WEIDMAN P.J., SERAFINI T., ORCI L. and J.E. ROTHMAN : A role for GTP-binding proteins in vesicular transport through the Golgi complex. In : Secretion and Its Control, Oxford G.S. & C.M. Armstrong eds. The Rockefeller University Press, New York, 1989, pp 175-188.

169. UNGER R.H. and L. ORCI : Glucagon. In : Diabetes Mellitus. Theory and Practice, Fourth Edition. Rifkin H. & Porte D. eds. Ellenberg & Rifkin’s, Elsevier, New York, 1990, pp 104-120.

170. ROTHMAN J.E. and L. ORCI : Movement of proteins through the Golgi stack : a molecular dissection of vesicular transport. The FASEB Journal 4, 1460-1468 (1990).

171. MONTESANO R., PEPPER M. and L. ORCI : Angiogenesis in vitro : Morphogenetic and invasive properties of endothelial cells. News in Phys. Sci. 5, 75-79 (1990).

172. BENOIT R., ESCH F., BENNETT H.P.J., LING N., RAVAZZOLA M., ORCI L. and E.J. MUFSON : Gene regulation, biosynthesis, and processing. Part II. Biosynthesis and processing. Processing of prosomatostatin. Metabolism 39, 22-25 (1990).

173. MONTESANO R., PEPPER M.S., VASSALLI J.-D. and L. ORCI : The control of angiogenesis : endothelial cell-matrix interactions and extracellular proteolysis. In: Meetings on Pathophysiology of Pulmonary Cells. Endothelial and Mucus secreting Cells. (Pozzi E., ed.) Masson Italia Periodici, Torino, 1991, pp 1-17.

174. MONTESANO R., PEPPER M.S., VASSALLI J.-D. and L. ORCI : Modulation of angiogenesis in vitro. In: Angiogenesis. (R. Steiner, P.B. Weisz & R. Langer eds.). Birkhäuser Verlag, Basel, 1992, pp 130-136.

175. PEPPER M.S., VASSALLI J.-D., ORCI L. and R. MONTESANO : Proteolytic balance and capillary morphogenesis in vitro. In: Angiogenesis. (R. Steiner, P.B. Weisz & R. Langer eds.). Birkhäuser Verlag, Basel, 1992, pp 138-145.

176. UNGER R. and L. ORCI Glucagon secretion, alpha cell metabolism, and glucagon action. In: Endocrinology, ed DeGroot. L (Saunders Compagny, Philadelphia), 3rd Edition. Chap 78, 1995, pp 1337-1353.

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177. PEPPER M.S., VASSALLI J.-D., ORCI L. and R. MONTESANO : Angiogenesis in vitro : Cytokine interactions and balanced extracellular proteolysis. Angiogenesis, 149-170, (1994).

178. MONTESANO R., VASSALLI J.-D., ORCI L. and M.S. PEPPER : The role of growth factors and extracellular matrix in angiogenesis and epithelial morphogenesis. Frontiers in Endocrinology (Developmental Endocrinology) P.C. Sizonenko, M.L. Aubert, J.-D. Vassalli, Ares Serono Symposia, 6, 43-66, (1994).

179. HERRERA P.-L., HUARTE J., SANVITO F., MEDA P., ORCI L. and J.-D. VASSALLI: Differentiation of pancreatic islet cells. Frontiers in Endocrinology (Developmental Endocrinology) P.C. Sizonenko, M.L. Aubert, J.-D. Vassalli, Ares Serono Symposia, 6, 105-110, (1994).

180. UNGER R. and L. ORCI : Glucagon secretion, alpha cell metabolism, and glucagon action. In : Endocrinology, ed DeGroot. L (Saunders Compagny, Philadelphia), 3rd Edition. Chap 78, 1337-1353 (1995).

181. PEPPER M., MANDRIOTA S., VASSALLI J.-D., ORCI L. and R. MONTESANO : Attempts to Understand Metastasis Formation II : Angiogenesis-regulating cytokines : activities and interactions. In : Curr. Topics in Microbiol. and Immunol. U. Günthert and W. Birchmeier (eds.). Springer-Verlag, Berlin and Heidelberg, 213/II, 31-67 (1996).

182. BEDNAREK S.-Y., ORCI L. and R. SCHEKMAN : The traffic COPs and the formation of vesicle coats. Trends Cell Biol. 6, 468-473 (1996).

183. PEPPER M., MONTESANO R., MANDRIOTA S.-J., ORCI L. and J.-D. VASSALLI : Angiogenesis : A paradigm for balanced extracellular proteolysis during cell migration and morphogenesis. Enzyme & Protein 49, 138-162 (1996).

184. SORIANO J.V., PEPPER M.S., ORCI L. and R. MONTESANO : Roles of hepatocyte growth factor/scatter factor and transforming growth factor-β

1 in mammary gland ductal

morphogenesis. J. Mamm. Gland Biol. Neoplasia 3, 133-150 (1998).

185. MENTHA G., RUBBIA-BRANDT L., ORCI L., BECKER Ch., GIOSTRA E., MAJNO P., BORISCH B., HADENGUE A. and P. MOREL : Traumatic neuroma with biliary duct obstruction after orthotopic liver transplantation. Transplantation 67, 177-179 (1999).

186. UNGER R. H., ZHOU Y.-T. and L. ORCI : Lipotoxicity. In : Diabetes Mellitus : A Fundamental and Clinical Text. 2e. Ed. by Le Roith, Taylor & Olefsky, Chap. 12, pp 132-141 (2000).

187. UNGER R.H. and L. ORCI : Lipoapoptosis : its mechanism and its diseases. Biochimica et Biophysica Acta 1585, 202-212 (2002).

188. KUSMINSKI C.M., SHETTY S., ORCI L., UNGER R.H., and SCHERER P.E. : Diabetes and apoptosis lipotoxicity. Apoptosis 14 (12), 1484-1495 (2009).

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41. VAN OBBERGHEN E., SOMERS G., DEVIS G. … complet.pdf · Lelio ORCI Publications - Page 3 - 30. LAMBERT A.E., BLONDEL B., KANAZAWA Y., ORCI L. and A.E. RENOLD : Monolayer cell