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3RD ANNUAL SYMPOSIUM
Clinical & Pharmaceutical Solutions through Analysis
MEETING PROGRAM
Where Technology and Solutions MeetWhere Discovery Meets the Clinic
Milestone Development Services
March 13 - 15, 2017University of Florida
Clinical & Translational Sciences Institute
WELCOME2017
March 13, 2017
Dear Colleagues:
On behalf of the organizing committee, our sponsors, and the University of Florida, it is our pleasure to welcome you to the 3rd Annual Metabolomics Symposium on Clinical and Pharmaceutical Solutions through Analysis (CPSA Metabolomics 2017). Our meeting promises to be timely with regard to unique analytical perspectives in the field and feature lively discussions, memorable interactions, and the sharing of real-world experiences.
The goal of CPSA Metabolomics is to provide timely, in-depth reviews of innovative technology and emerging practices in the clinic through open discussion of industry related issues and needs. Our aim is to feature scientific leaders within diversified symposia and sponsored events specially designed to be highly interactive where professionals can openly share their experiences and visions in a collegial setting – where technology and solutions meet!
We are delighted to feature, Dr. Irwin Kurland of the Albert Einstein College of Medicine, as our plenary speaker. His lecture “Metabolic Phenotyping: From Model Organisms to Man” will provide insight into his premier research and his novel stable isotope based flux phenotyping methodology on a mass spectrometry platform.
The symposia sessions provide a wonderful opportunity to interact with industry leaders as well as openly share experiences – from the laboratory to the clinic. Specific issues and needs from previous CPSA annual meetings in the USA, China and Brazil will continue at CPSA Metabolomics and feature: 1) clinical applications and workflows; 2) crossover technologies and methods derived from proteomics; 3) biomarker discovery; 4) informatics and multiple/patterned data sets; 5) preferred analytical platforms; 6) sample preparation and chemistries; and 7) novel multianalyte quantitation approaches.
Our annual meeting will once again feature poster sessions, an interactive sponsors exhibition, and a graduate student workshop that highlights experiences and lessons learned by our distinguished Mentors – what they wish they would have known when they were students! Pre-conference events – CPSA OPEN and CPSA 5K – along with our Workshop and Metabolomics Lecture Series will help set the stage for our annual meeting.
We are in the midst of a most challenging time in healthcare. Please help lead the way by actively participating, freely interacting, and sharing ideas during the event and afterwards. Creativity and imagination have been key ingredients to making CPSA meetings – here in Gainesville and all over the world – a memorable experience. In this way, a genuine passion for the analytical sciences can lead to personal growth as well as opportunities to significantly impact the field through participation and leadership.
Finally, special thanks go to the sponsors of CPSA Metabolomics. In particular, we wish to thank Bruker Daltonics, McKinley Scientific, New Objective, SCIEX, Thermo Fisher Scientific, Waters Corporation, and the University of Florida for giving this meeting life. Thank you! All CPSA sponsors share the passion and commitment for both innovative technologies and relationships.
Enjoy the meeting – a celebration of the sciences – and of course, where technology and solutions meet!
Sincerely,
Mike S. Lee, Ph.D.CPSA Founder
Timothy J. Garrett, Ph.D.CPSA Metabolomics Program Chair
©2017 Waters Corporation. Waters, Vion and the Science of What’s Possible are registered trademarks of Waters Corporation.
IN THE COMPLEX WORLD OF METABOLITES, WELCOME TO CLARITY.Join Omics researchers doing more with ion mobility.
Deeper sample coverage. Highly selective quantification. Confident identification of analytes that once hid in plain sight. That’s what happens when Omics researchers harness the power of ion mobility and partner with Waters—the pioneer in ion mobility technology. If you’re ready to take your Omics research to the next level, visit waters.com/clarity
PHARMACEUTICAL ■ HEALTH SCIENCES ■ FOOD ■ ENVIRONMENTAL ■ CHEMICAL MATERIALS
PUBS:AAPSAir, Water & Environment InternationalChromatography TodayDrug Discovery WorldEuropean BioPharmaceutical ReviewEuropean Pharmaceutical ReviewFood Engineering & Ingredients Europe Food Safety EuropeJournal of the American Society for Mass SpectrometryNext Generation PharmaceuticalRapid Communications in Mass SpectrometrySpectroscopy Asia/EuropeTouch BriefingsWell Characterized BioPharmaceutical
Job Name: WATR18971_B_Vion Omics_2017_DBmec.indd
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SPONSORSThank You!
The CPSA Metabolomics Symposium is made possible by the broad-based support of industry sponsors. The passion for the analytical sciences and the accelerated discovery and development of pharmaceuticals is shared by each sponsor. As a result, the event is dedicated to promoting awareness and understanding of the issues and needs associated with research and development in the hopes of inspiring significant advances in the field.
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Where Technology and Solutions Meet. Where Discovery Meets the Clinic. March 13 - 15, 2017
PROGRAM CHAIR
Timothy GarrettUniversity of Florida
Aiko BarschBruker Daltonics
Bradley AckermannEli Lilly & Company
Andrey BondarenkoInfoClinika
Alex BukoHuman Metabolome Technologies America
Jose Castro-PerezWaters Corporation
Donald ChaceMedolac Laboratories
Paul CorcoranMcKinley Scientific
Gabriele CrucianiUniversity of Perugia
Leigh DarbeeMcKinley Scientific
Susmita DattaUniversity of Florida
Emily EhrenfeldNew Objective
Teresa FanUniversity of Kentucky
Steve FanninBruker Daltonics
Todd GillespieEli Lilly & Co.
Erik HansenNew Objective
Faith HaysShimadzu
David HeywoodWaters Corporation
Rick HigashiUniversity of Kentucky
Gene InmanEli Lilly & Co. (Retired)
John JaniszewskiPfizer
Qin JiBristol Myers Squibb
Richard KibbeyYale University
Steve KlohrBristol-Myers Squibb
Alla KlossGenzyme
Irwin KurlandAlbert Einstein College of Medicine
Ken LewisOpAns
Yutai LiMerck
Gustavo MaegawaUniversity of Florida
Tom MetzPacific Northwest Research Labs
Nicole MatzPRA Health Sciences
Eric MilgramPepsiCo
Alisha Mitchell-RobertsUniversity of Florida
Shane NeedhamAlturas Analytics
Fred RegnierPurdue University
Michelle ReidUniversity of Florida
Nalini SadagopanAgilent Technologies
Jim ShenBristol-Myers Squibb
Petia ShipkovaBristol-Myers Squibb
David SwinneyInstitute for Rare and Neglected Diseases
Jeremiah TiptonBioTech & OMICx Solutions
Baljit UbhiSCIEX
Gary ValaskovicNew Objective
2017 ORGANIZING COMMITTEE
SYMPOSIA & SESSIONS
Roy VazSanofi
Sihe WangCleveland Clinic
Naidong WengJanssen Pharmaceuticals
Eric YangGlaxoSmithKline
Nathan YatesUniversity of Pittsburgh
Richard YostUniversity of Florida
Ismael ZamoraMolecular Discovery
LOGISTICS & MANAGEMENT
Communications & Media
Carla Marshall-WaggettNew Objective
Martin SteelMcKinley Scientific
Management & Correspondence
Mike LeeMilestone Development Services
EVENTSSunday March 12
4:00 PM - 6:00 PM CPSA 5K CPSA Charitable Foundation
Meet & Start at Where Technology and Relationship Meet the RoadUF Hilton and Conference Center Join us for the CPSA 5K! Walk, run or bike the scenic course through the beautiful UF campus.
Organizers: Timothy Garrett, University of Florida; Nicole Matz, PRA Health Sciences; Michelle Reid, University of Florida; Martin Steel, McKinley Scientific; Shane Needham, Alturas Analytics;
Together We Can Go Farther!
9:00 AM CPSA OPEN GOLF EVENT CPSA Charitable Foundation
Mark Bostick Golf Course Organizers: Paul Corcoran, McKinley Scientific and University of Florida Steve Fannin, Bruker Daltonics
10:00 AM REGISTRATION
3rd Floor Lobby
1:00 PM - 4:00 PM PRE-CONFERENCE WORKSHOP
Don Chace, Medolac Laboratories, and Mike Lee, Milestone Development Services
5:00 PM - 7:00 PM RECEPTION & METABOLOMICS LECTURE SERIES
Hosted by Waters Corporation
� Opening RemarksTimothy Garrett, University of Florida and Mike Lee, Milestone Development Services
� Welcome and IntroductionSuraj Dhungana, Waters Corporation
� Applications of Metabolomics for Clinical and Translational ResearchAmrita Cheema, Georgetown University
WORKSHOP & RECEPTION
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Where Technology and Solutions Meet. Where Discovery Meets the Clinic.
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By collaborating with the scientific community, we’ve developed pioneering Thermo Scientific™ Orbitrap™ MS solutions combined with the most comprehensive breadth of chromatographic separations to detect and resolve chemically diverse compounds in the metabolome. These industry-leading solutions deliver the most precise, accurate, and confident metabolite profiles and identifications more quickly so you can go beyond the limit of what was ever thought possible.
Find out more at thermofisher.com/metabolomics
© 2017 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified. AD90245-EN0217S
Harness the power of metabolomics to gain in-depth biological insights and advance scientific research
Learn more at booth #1 and be sure to attend our lunch seminar on Tuesday, March 14th from 11:30 a.m. to 1:30 p.m.
Go beyondwith proven metabolomics solutions
Metabolomics with the X500R QTOF is an everyday, robust, integrated benchtop system with the performance needed for metabolic profi ling and requires minimal MS expertise.
Simplifi ed OperationEngineered for simplicity and service accessibility-Single Injection Flow and an N-optic design, heated TOF, integrated calibration all with a minimized footprint
Identify and quantify large numbers of Routine Metabolomics with the X500R
metabolites on a routine basis—fast.
Visit the SCIEX booth to learn how to simplify your metabolomics workfl ow. Measure, process, characterize and translate your research into biological knowledge fast.
One Single Integrated Interface!The SCIEX OS Software Platform puts MS control, data processing and reporting at your fi ngertips. The guided workfl ow allows for minimal MS expertise and gets you to biological insights fast
Libraries Enable Higher Confi dence in Metabolite Identifi cationGet to actionable results quickly with user-friendly processing software and a validated biologically relevant metabolite library that can be expanded with other validated libraries
Routine and RobustAutomated and integrated mass calibration allows enhanced stability while new diagnostic and tuning tools allow for more uptime.
Maximize your Lab’s Effi ciencyThe X500R QTOF, with N-TOF technology has a compact TOF tube and a foot print of 25 cubic-feet, it occupies less lab space than any other HRMS on the market today
The guided workfl ow allows for minimal MS expertise and gets you to biological insights fast
Maximize your Lab’s Effi ciency
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AB Sciex is doing business as SCIEX. © 2017 AB Sciex. For research use only. Not for use in diagnostic procedures. The trademarks mentioned herein are the property of the AB Sciex Pte. Ltd. or their respective owners. AB SCIEX™ is being used under license.
02/2017 RUO-MKT-07-5081-A
X500R_Metabolomics_CPSA_Ad_d2.indd 1 1/24/17 12:00 PM
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PROGRAMTuesday March 14
7:30 AM – 8:30 AM REGISTRATION & WAKE-UP COFFEE
8:30 AM – 8:45 AM WELCOME & OPENING REMARKS - DISEASE IS THE ENEMY!
Welcome
Mike Lee, Milestone Development Services
Objectives, Format, and Opening Remarks
Timothy Garrett, University of Florida
8:45 AM - 9:30 AM PLENARY LECTURE
Metabolic Phenotyping: From Model Organisms to Man
Irwin Kurland, Einstein College of Medicine
9:45 AM - 11:15 AM SYMPOSIUM SESSION
Biomarker Stability/Sample Integrity
Discussion Leader: Alla Kloss, Genzyme
� One Chapter From a Manual on How to Ruin a Metabolomics StudyAlla Kloss, Sanofi
� Biomarkers for Human Plasma Sample Quality using an IROA-Labeled Universal Internal StandardCasey Chamberlain, University of Florida
� Examining Heat Treatment for Stabilization of the Lipidome Jeremy Koelmel, University of Florida
Gain deeper biological insight into complex samples
Benefit from combined NMR and MS solutions
Improve your productivity by dedicated Metabolomics workflows
Understand the structure and interactions of molecules
Innovation with IntegrityMass Spectrometry
For research use only. Not for use in diagnostic procedures
For more information, visit www.bruker.com or email [email protected]
Bruker Is the Smart Solution For All Your Metabolomics Challenges
www.cpsa-analytics.com
2017
Chris JohnsonPittsburgh Pirates
Plenary Speaker
Nathan A. YatesUniversity of Pittsburgh
Program Chair
Make plans now to attend CPSA Analytics 2017! This annual meeting is destined to become the premier industry-led event dedicated to promoting awareness of issues
and needs in collaborative data processing and dissemination
Where Technology and Personalized Healthcare Meet
May 17 - 18, 2017Hosted by The University of Pittsburgh
2nd Annual Analytics Symposium onClinical & Pharmaceutical Solutions through Analysis
CPSA Analytics 2018
Symposia • Roundtables • Workshops • Events
PROGRAMWednesday March 15
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Where Technology and Solutions Meet. Where Discovery Meets the Clinic. March 13 - 15, 2017
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PROGRAMTuesday March 14
7:30 AM - 8:30 AM REGISTRATION & WAKE-UP COFFEE
8:30 AM - 10:00 AM SYMPOSIUM SESSION
Investigating Homeostasis: Technologies and Methodologies for Drug Discovery
Discussion Leader: John Janiszewski, Pfizer
� Using Metabolism To Support Drug Discovery: From Target Identification To Biomarker Validation David Pirman, Agios
� Leveraging MIMOSA-Based Fluxomics To Unravel The Mechanism Of Action of Lead Matter In Early Drug Discovery Darren Dumlao, Pfizer
� Fluxing Around: Creating Computational Infrastructure for Metabolic Labeling Experiments Abhishek Jha, Elucidata
10:15 AM - 11:45 AM SYMPOSIUM SESSION
Multi-Omic Integration in the Clinical Sciences
Discussion Leader: Irwin Kurland, Albert Einstein College of Medicine
� Propionate Induces an Apparent Conflict Between Fluxomic and Metabolomic Measures in the Perfused Mouse HeartMatthew Merritt, University of Florida
� The Age Of Multi-Omics Has Arrived - Accelerating Integrated Perspectives In BiologyDevin Drew, Thermo Fisher Scientific
� OneOmics™: Integrate Multi-Omics Data Seamlessly in the CloudMatthew Skaley, SCIEX
12:00 PM - 2:00 PM LUNCH: VENDOR SPOTLIGHT & POSTER REVIEW
Sponsored by Bruker Daltonics
A Multi-Omics Study Elucidates an Increase in Pio-Production EfficiencyGary Kruppa, Bruker
Lunch served in lobby as you mix and mingle with our vendors and poster authors
11:30 AM – 1:30 PM LUNCH: VENDOR SPOTLIGHT & POSTER REVIEW
Sponsored by Thermo Fisher Scientific
� Removing the Data Processing Bottleneck: Move Efficiently from Data to Structure to Pathway with NEW Thermo Scientific™ Compound Discoverer™ 2.0Amanda Souza, Thermo Fisher Scientific
� Profiling of Organic Acids in Mouse Muscle Using Ion Chromatography/MSChristopher Petucci, Sanford Burnham Presby Medical Discovery Institute
� Using Proteometabolomics to Examine Mechanisms of Drug Resistance in Multiple MyelomaJohn Koomen, H. Lee Moffitt Cancer Center and Research Institute
Lunch served in lobby. Join the session, mix and mingle with our vendors and poster authors
1:45 PM - 3:00 PM SYMPOSIUM SESSION
Personalized Metabolism
Discussion Leaders: Don Chace, Medolac Laboratories and Emily Ehrenfeld, New Objective
� Using Proteometabolomics to Examine Mechanisms of Drug Resistance in Multiple Myeloma John Koomen, H. Lee Moffitt Cancer Center and Research Institute
� Translational Metabolomics in Biopharma Michael Reily, Bristol-Myers Squibb
� Metabolomics in the Clinic: Discriminating Between Research/Development and Application/Service Don Chace, Medolac Laboratories
3:30 PM - 5:00 PM SYMPOSIUM SESSION
Clinical Applications of Metabolomics and It’s Role on Diagnosis and Therapeutic Response and Monitoring
Discussion Leader: Gustavo Maegawa, University of Florida
� Use of Ion Chromatography/Mass Spectrometry for Targeted Metabolite Profiling of Polar Organic AcidsChris Petucci, Sanford-Burnham Medical Research Institute
� Routine Discovery Metabolomics Workflows on X500R QTOF SystemMatthew Skaley, SCIEX
6:00 PM SPONSORED SOCIAL EVENT
McKethan Stadium Sponsored by McKinley Scientific & New Objective
First pitch: 6:30 pm Play Ball! Gators vs. Florida State SeminolesMcKethan Stadium on the University of Florida campus vs.
PROGRAMWednesday March 15
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Where Technology and Solutions Meet. Where Discovery Meets the Clinic.
215 PM - 3:45 PM SYMPOSIUM SESSION
Customers Meet Vendors
Discussion Leader: Alla Kloss, Genzyme
Customer PanelDarren Dumlao, PfizerHarvey Lieberman, SanofiDavid Pirman, Agios Pharmaceuticals
Vendor PanelRalf Bogumil, BiocratesSuraj Dhungana, Waters CorporationFaith Hays, Shimadzu Scientific InstrumentsKen Jones, SCIEXGary Kruppa, BrukerChristine Miller, Agilent TechnologiesMatthew Skaley, SCIEXAmanda Souza, Thermo Fisher Scientific
4:00 PM - 5:00 PM GRADUATE STUDENT SESSION
Catalyzing Curiosity: Bridging Passion and Discovery
Curiosity is perceived to be an innate quality and essential characteristic of any scientist. The ideas, which flow from imagination into high-impact research, are seemingly natural; graduate school, and specifically doctoral education, is the ideal environment to cultivate this creativity and intuition. Let’s examine the relationships between initial questions, unexpected developments, and the growth of new curiosity-driven chemistry.
Mentors: Don Chace, Medolac Laboratories; Paul Corcoran, McKinley Scientific; Gabriele Cruciani, University of Perugia; Steve Fannin, Bruker; Todd Gillespie, Eli Lilly & Co.; Faith Hays, Shimadzu; David Heywood, Waters; Eugene Inman, Eli Lilly and Co. (Ret); John Janiszewski, Pfizer; Alla Kloss, Genzyme; Yutai Li, Merck; Carla Marshall-Waggett, New Objective; Nalini Sadagopan, Agilent Technologies; Martin Steel, McKinley Scientific; Jeremiah Tipton, BioTech & OMICs Solutions; Baljit Ubhi, SCIEX; Roy Vaz, Sanofi; Richard Yost, University of Florida
5:15 PM CLOSING REMARKS
Timothy Garrett, University of Florida
WED
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