Vol. 268, No. 12 The Journal of April 25, 1993

Biological Chemistry Copyright 0 1993 by the American Society for Biochemistry and Molecular Biology, Inc.

428 East Preston St.. Baltimore. MD 21202 U.S.A.

CONTENTS

MINIREVIEW 8383 The anaerobic ribonucleotide reductase from Esche-

richiu coli. Peter Reichard

COMMUNICATIONS 8387 The mitochondrial targeting presequence of the Rieske

iron-sulfur protein is processed in a single step after insertion into the cytochrome bc, complex in mammals and retained as a subunit in the complex. Ulrich Brandt, Linda Yu, Chang-An Yu, and Bernard L. Trumpower

8391 Phosphorylation and dephosphorylation catalyzed in uitro by purified components of the nitrate sensing system, NarX and NarL. Margaret S. Walker and John A. DeMoss

8447 Binding of lipoprotein lipase to heparin. Identification of five critical residues in two distinct segments of the

Steue Sutherlund, Mitsuru Emi, Zhang Shuhua, Richard L. amino-terminal domain. Akira Hata, Dauid N. Ridinger,

Myers, Kuishu Ren, Tong Cheng, Ituro Inow, Dana E. Wilson. Per-Henrik Iuerius, and Jean-Marc Lalouel

8458 PACE/furin can process the vitamin K-dependent pro- factor IX precursor within the secretory pathway.

Randal J. Kaufman Louise C. Wasley, Alnawaz Rehemtullo, J . Andrew Bristol, and

8466 Ionizing radiation induces expression of interleukin 6 by human fibroblasts involving activation of nuclear factor-&. Marion Andrea Brach, Hans-Jiirgen Grub, Tsuneyasu Kaisho, Yoshinobu Asano, Toshio Hirano, and Friedhelm Herrmann

8394 Phosphorylation and activation of the Ca2+-pumping 8473 Pituitary-specific repression of placental members of ATPase of cardiac sarcoplasmic reticulum by Caa+/cal- the human growth hormone gene family. A possible modulin-dependent protein kinase. Ande Xu, Cynthia mechanism for locus regulation. Mark W. Nachtigal, Bar- Hawkins, and Njamor Narayanan bara E. Nickel, and Peter A. Cattini

8398

8402

8406

8410

8414

8418

8422

8425

Phosphorylation of mitogen-activated protein kinases is involved in the epidermal growth factor and phorbol ester, but not in the thyrotropinlcAMP, thyroid mito- genic pathway. Frawoise Lamy, Frawoise Wilkin, Mireille Baptist, James Posada, Pierre P. Roger, and Jacques E. Dumont

Specificity of Goodpasture autoantibodies for the re- combinant noncollagenous domains of human type IV collagen. Eric G. Neilson, Raghuram KaUuri, Mae Jane Sun, Sripad Gunwar, Theodore Danofh Mariko Mariyama, Jeanne C. Myers, Stephen T. Reeders, and Billy G. Hudson

Calcium-dependent cyclosporin A-sensitive activation of the interleukin-2 promoter by ~ 6 6 ' " ~ . Cosima T. Bal- dari, Adrianu Heguy, and John L. Telford

Endothelial nitric oxide synthase. N-terminal myris-

Busconi and Thomas Michel toylation determines subcellular localization. Liliana

factor, oncostatin M, and ciliary neurotrophic factor in Reconstitution of the response to leukemia inhibitory

Mosley, Karen K. Morello, Sanja Pajouic, and Dauid P. Gearing hepatoma cells. Heinz Baumann, Steuen F. Ziegler, Bruce

A Na+-dependent creatine transporter in rabbit brain, muscle, heart, and kidney. cDNA cloning and func- tional expression. Cecile Guimbal and Manfred W. Kilimann

Evolution of the type I1 hexokinase gene by duplication

of its organization. Kentaro Kogure, Yasun Shinohura, and and fusion of the glucokinase gene with conservation

Hiroshi Terada

Sinusoidal oscillations in intracellular calcium requir-

Bird, Michel F. Rossier, Johnny F. Obie, and James W. Putney, ing negative feedback by protein kinase C. Gary St. J.

Jr.

ARTICLES 8429 Hisees is the catalytically important histidyl residue of

Syrian hamster 3-hydroxy-3-methylglutaryl-coen- zyme A reductase. Bryant G. Darnay and Victor W. Rodwell

8436 Domain structure and domain-domain interactions in human coagulation factor IX. Alexander Vysotchin, Leonid V. Medued, and Kenneth C. Zngham

8480

8491

8497

8503

8507

8514

8529

8536

Phosphatidic acid, lysophosphatidic acid, and lipid A are inhibitors of glycosylphosphatidylinositol-specific phospholipase D. Specific inhibition of a phospholipase by product analogues? Martin G. Low and Kuo-Sen Huang

Guanine nucleotides activate multiple signaling path- ways in permeabilized gastric chief cells. Evidence for GTPYS-Induced calcium-independent pepsinogen se- cretion. Robert D. Raffaniello and Jean-Pierre Raufman

Inhibition of apolipoprotein E degradation in a post- Golgi compartment by a cysteine protease inhibitor. Shui Q. Ye, Catherine A. Reardon, and Godfrey S. Getz

Iodide as the mediator for the reductive reactions of peroxidases. Manish M. Shah and Steuen D. Aust

Nucleotide binding properties of bovine brain uncoat-

Evan Eisenberg ing ATPase. Baochoiig Gao, Yumiko Emoto, Lois Greene, and

Kinetics of GLUT1 and GLUT4 glucose transporters expressed in Xenopus Oocytes. Haruo Nishimura, Federico

and Morris J . Birnbaum V. Pallardo, Glen A. Seidner, Susan Vannucci, Ian A. Simpson,

Characterization of transferrin-independent iron transport in K662 cells. Unique properties provide evi-

Inman and Marianne Wessling-Resnick dence for multiple pathways of iron uptake. Robin S.

Identification of potential active-site residues in the human poly(ADP-ribose) polymerase. Frederic Simonin, Oliuier Poch, Marc Delorue, and Gilbert de Murcia

Inhibition by tentoxin of cooperativity among nucleo- tide binding sites on chloroplast coupling factor 1. Ning- mei Hu, Denise A. Mills, Bernhurd Huchzermeyer, and Mark L. Richter

8541 Structure-function studies of yeast ferrochelatase. Identification and functional analysis of amino acid substitutions that increase V,. an,d the KM for both substrates. Abdelhamid Abbas and Rosrne Lubbe-Bois

8547 Distinct subdomains of human endothelin receptors de- termine their selectivity to endothelinA-selective antag-

Masashi Yanagisawa, Tatsuya Sawamura, Taijiro Enoki, To- onist and endothelinB-selective agonists. Aiji Sakamoto,

shio Ohtani, Takeshi Sakurai, Kazuwa Nakoo, Teruhiko Toyo-oh, and Tomoh Masaki

V

8554

8564

8569

8574

8580

8590

8596

8608

8617

8624

8632

8640

8645

8651

8658

8665

8669

8675

Heme coordination of prostaglandin H synthase. Ah-Lim Tsai, Richard J. Kulmacz, Jinn-Shyan Wang, Yang Wang, Harold E. Van Wart, and Graham Palmer

Thapsigargin causes Caa+ release and collapse of the membrane potential of %panosoma brucei mitochon-

E. Vercesi, Silvia N . J. Moreno, Celene F. Bernnrdes, Andre dria in situ and of isolated rat liver mitochondria. Anibal

R. Meinicke, Eloise C. Fernundes, and Roberto Docampo

Cholesterol loading of macrophages leads to marked enhancement of native lipoprotein(a) and apoprotein(a)

A. Keesler, Gunther M. Fless, and Ira Tabas internalization and degradation. Lori A. Bottalico, George

Fibrin affinity of urokinase-type plasminogen activa- tor. Evidence that Znz+ mediates strong and specific interaction of single-chain urokinase with fibrin. S. Shaukat Husain

'H NMR-based determination of the three-dimensional

containing inter-chain disulfide bonds. Leela Kar, structure of the human plasma fibronectin fragment

Ching-San h i , Carl E. Wolff, David Nettesheim, Simon Sher- man, and Michael E. Johnson

An anticoagulant peptide from the Indian leech. Isolation, sequence analysis, and cloning of haemadin.

Karl-Hermann Strube, Burkhard Krager, Siegfried Bialojan, Marcus Otte, and Johannes Dodt

labeled substrates or inhibitors by reduced protocate- Simultaneous binding of nitric oxide and isotopically

Lipscomb chuate 3,4-dioxygenase. Allen M. Orville and John D.

free plasma can be attributed specifically to attenuation The effect of activated protein C on fibrinolysis in cell-

Nesheim of prothrombin activation. Laszlo Bajzar and Michuel

Identification of two hyaluronan-binding domains in the hyaluronan receptor RHAMM. Baihuu Yang, Liying Zhang, and Eva Ann Turley

The respiratory burst oxidase of human neutrophils. Guanine nucleotides and arachidonate regulate the as- sembly of a multicomponent complex in a semirecom-

K. Leigh Inge, and J. David Lumbeth binant cell-free system. David J. Uhlinger, Shiv Raj Tyagi,

Role of protein phosphorylation and dephosphorylation in activation and desensitization of the CAMP-depend- ent Na+/H+ antiport. Hikne Gu i zowr , Franck Borgese, Bernnrd Pellissier, Federico Garcia-Romeu, and Re& Motais

A novel K+ current inhibited by adrenocorticotropic hormone and angiotensin I1 in adrenal cortical cells. Boris Mlinar, Bruce A. Biugi, and John J. Enyeart

Determination of the DNA bend angle induced by the

M 8 + . Tim0 Stover, Eleonore Kohler, Ursula Fagin, Wolfgang restriction endonuclease EcoRV in the presence of

Wende, Heiner Wolfes, and Alfred Pingoud

The function and distinctive regulation of the integrin

aggregation. Jonathan B. Wertzman, Renata Pasqualini, VLA-3 in cell adhesion, spreading, and homotypic cell

Yoshikazu Takada, and Martin E. Hemler

Immunoaffinity purification and characterization of 7-

ebral cortex. Hiroshi Nakayasu, Masao Nishikawa, Hiroshi aminobutyric acid (GABA)B receptor from bovine cer-

Mizutani, Hiroshi Kimura, and Kinya Kuriyama

Saccharomyces cereuisiae elongation factor 2. Muta- genesis of the histidine precursor of diphthamide yields a functional protein that is resistant to diphtheria toxin. Lon D. Phan, John P. Perentesis, and James W. Bodley

Reversible palmitoylation of the protein-tyrosine ki-

Harrison, John M. Cassady, and Robert L. Geahlen nase ~ 6 6 ~ ' . Lisa A. Paige, Monica J. S. Nadler, Marietta L.

I n organello footprinting. Analysis of protein binding at regulatory regions in bovine mitochondrial DNA. Steven C. Ghivizzani, Cort S. Madsen, and William W . Hauswirth

8683

8692

8698

8704

871 1

8717

8727

8735

8743

8752

8760

8769

8777

8781

8787

8793

8801

8808

Nucleotide binding to actin. Cation dependence of nu- cleotide dissociation and exchange rates. Henry J. Kin- osian, Lynn A. Selden, James E. Estes, and Lewis C. Gershman

G protein-mediated inhibition of phospholipase C activ-

hnn Sulkholutskaya, and Cong Weng ity in a solubilized membrane preparation. Irene Litosch,

Phosphorylation of HIV-1 gag proteins by protein ki- nase C. Barry Burnette, Gang Yu, and Ronnld L. Felsted

Inhibitory properties of full-length and truncated re-

dence that the third Kunitz-type domain of TFPI is not combinant tissue factor pathway inhibitor (TFPI). Evi-

essential for the inhibition of factor VIIa-tissue factor complexes on cell surfaces. Takayoshi Hamamoto, Masak- uni Yamamoto, Ole Nordfang, Jens G. Litske Petersen, Donald C. Foster, and Walter Kisiel

Presence of the protein-glycosaminoglycan-protein co- valent cross-link in the inter-a-inhibitor-related pro- teinase inhibitor heavy chain 2bikunin. Jan J. Enghild, Guy Salvesen, Ida 8. ThBgersen, Zuzana Valnickova, Salvatore V. Pizzo, and Stanley A. Hefta

Mutagenic analysis of AMP nucleosidase from Esche- richia coli. Deletion of a region similar to AMP deam- inase and peptide characterization by mass spectrome- try. Kalla Kvalnes-Krick, James E. Lubdon, Xiaoyan Ma, Edward Nieves, and Vern L. Schramm

Lysine 87 in the f i subunit of tryptophan synthase that forms an internal aldimine with pyridoxal phosphate serves critical roles in transimination, catalysis, and product release. Zichun Lu, Shinji Nagata, Peter McPhie, and Edith Wilson Miles

Characterization of the purified vitamin K-dependent 7-glutamyl carboxylase. Daniel P. Morris, Berry A. M. Soute, Cees Vermeer, and Darrel W. Stafford

Human immunodeficiency virus reverse transcriptase. A kinetic analysis of RNA-dependent and DNA- dependent DNA polymerization. John E. Reardon

Dityrosine and tyrosine oxidation products are endog-

tively modified red blood cell hemoglobin by (the 19 S) enous markers for the selective proteolysis of oxida-

proteasome. Cecilia Giulivi and Kelvin J. A. Davies

Caz+-activated K+ transport in erythrocytes. Compari- son of binding and transport inhibition by scorpion

Alper toxins. Carlo Brugnara, Lucia De Franceschi, and Seth L.

Properties and regulation of the cell cycle-specific NIMA protein kinase of A S p e r g i l l U S nidulans. Kun Ping Lu, Stephen A. Osmani, and Anthony R. Means

Formation of a stable adduct between ubiquitin and the Arabidopais ubiquitin-conjugating enzyme, AtUBCl+. Michael L. Sullivan and Richard D. Vierstra

Triacylglycerol synthesis by an sn-l,2(2,3)-diacylglyc-

ard Lehner and Arnis Kuksis erol transacylase from rat intestinal microsomes. Rich-

ADP induces inositol phosphate-independent intracel- lular Cas+ mobilization in brain capillary endothelial cells. Christian Frelin, Jean Philippe Breittmayer, and Paul Vigne

Characterization of the human ADP-ribosylation fac- tor 3 promoter. Transcriptional regulation of a TATA- less promoter. Randy S. Ham, Joel Moss, and Martha Vaughn

ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl-terminal ADP-ribosylation factor do- main. Koichi Mishrma, Mrkako Tsuchrya, Maria S. Nightin- gale, Joel Moss, and Martha Vaughn

Identification of a new cell adhesion motif in two ho- mologous peptides from the COOH-terminal cell bind- ing domain of human thrombospondin. Minh D. Kosfeld and William A. Frazier

vi

8815

8825

8835

8842

8851

8855

8862

8871

8881

8888

8893

8899

8908

8919

8927

8935

8943

8949

8958

complex binding process. Catherine Bardelle, Bruce Furie, Membrane binding kinetics of factor VI11 indicate a

Barbara C. Furie, and Gary E. Gilbert

genomic DNA sequences of mouse 180-kilodalton bul- Cloning of type XVII collagen. Complementary and

lous pemphigoid antigen (BPAG2) predict an inter- rupted collagenous domain, a transmembrane segment, and unusual features in the 5’-end of the gene and the 3‘-untranslated region of the mRNA. Kehua Li, Katsuto Tamai, Elaine M. L. Tan, and Jouni Uitto

Cloning of an inflammation-specific phosphatidyl ino- sitol-linked form of murine vascular cell adhesion mol- ecule-l. Pamela Moy, Roy Lobb, Richard Tizard, Dian Olson, and Catherine Hesszon

Molecular cloning and genomic organization of a gene for luciferin-binding protein from the dinoflagellate Gonyaulax polyedra. Dong-Hee Lee, Maria Mittag, Steve Sczekan, David Morse, and J . Woodland Hastings

Calcium: a mediator of the cellular response to chronic Na+/K+-ATPase inhibition. Barbara M. Rayson

RNR-1, a nuclear receptor in the NGFI-BfNur77 fam- ily that is rapidly induced in regenerating liver. L. Marie Scearce, Thomas M. Laz, Thomas G. Hazel, Lester F. Lau, and Rebecca Taub

An enhancer for transcription of collagen IV genes is

Kaytes, and Markku Kurkinen activated by FQ cell differentiation. Shizuko Tanaka, Paul

Identification of a novel cyclin-like protein in human tumor cells. Richard T. Williams, Lingtao Wu, Denise A. Carbonaro-Hall, Vernon T. Tolo, and Frederick L. Hall

Association of heterogeneous nuclear ribonucleopro- tein A1 and C proteins with reiterated AUUUA se- quences. B. JoNell Hamilton, Eszter Nagy, James S. Malter, Bradley A. Arrick, and William F. C. Rigby

Cloning, expression, and characterization of Crypto- coccus neoforrnans dihydrofolate reductase. Worachart Sirawaraporn, Ming Cao, Daniel V. Santi, and Jeffrey C. Edman

A basis for differentiating among the multiple human Mu-glutathione S-transferases and molecular cloning of brain GSTM6. Yasuo Takahashi, Eggerton A. Campbell, Yasuji Hirata, Tetsuji Takayam, and Irving Listowsky

Regulation of G protein function by an effector in GTP-

of cGMP phosphodiesterase inhibits GTP hydrolysis by dependent signal transduction. An inhibitory subunit

transducin in vertebrate rod photoreceptors. Akio Ya-

Kathryn 0. Umbarger, Lara D. Hutson, William T. Madland, mazaki, Matsuyo Yamazaki, Seiji Tsuboi, Akio Kishigami,

and Fumio Hayashi

DNA determinants of restriction. Bacteriophage T4 endonuclease 11-dependent cleavage of plasmid DNA in

and Linda D. Kosturko viuo. Karin Carlson, Margareta Krabbe, Anna-Chey Nystrom,

Biosynthesis of human fibrinogen. Subunit interactions and potential intermediates in the assembly. Shaoming Huang, Eileen R. Muluihill, David H. Farrell, Dominic W. Chung, and Earl W. Dauie

Platelet-derived growth factor stimulates a biphasic mobilization of arachidonic acid in Swiss 3T3 cells. The role of phospholipase A=. Jan Domin and Enrique Rozengurt

Structural analysis of the myoglobin reconstituted with iron porphine. Saburo Neya, Noriaki Fuasaki, Taka0 Sato, Noriyuki Igarashi, and Nobuo Tanaka

Interference by PR-bound RNA polymerase with PRM function in vitro. Modulation by the bacteriophage X cI protein. Pamela A. Hershberger, Barry C. Mita, Amporn Tripatara, and Pieter L. deHaseth

Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the GO state. Robert J . Pignolo, Vincent J . Cristojalo, and Mitch 0. Rotenberg

CD45-associated kinase activity requires Zck but not T cell receptor expression in the Jurkat T cell line. Gary A. Koretzky, Mark Kohmetscher, and Susan Ross

8965

8972

8980

8990

8999

9005

9014

9023

9035

9041

9049

9055

9063

9071

9079

9092

9098

9105

Inhibition of the copper incorporation into ceruloplas- min leads to the deficiency in serum ceruloplasmin activity in Long-Evans Cinnamon mutant rat. Takahisa Yamnda, Takashi Agui, Yasuo Suzuki, Mitsuru Sato, and Kozo Matsumoto

Conformational change and membrane association of the PutA protein are coincident with reduction of its FAD cofactor by proline. Eric D. Brown and Janet M. Wood

Transfected G.la inhibits the calcium dependence of 8- adrenergic stimulated CAMP accumulation in C6 glioma cells. Nathulie Charpentier, Laurent Prizeau, Josiane Carrette, Rosalia Bertorelli, Ginette Le Cam, Olivier Manzoni, Joel Bockaert, and Vincent Homburger

Phenotypic analysis of proteinase A mutants. Implica- tions for autoactivation and the maturation pathway of the vacuolar hydrolases of Saccharomyces cerevisiae.

F. Tam, Michael A. Innis, and Elizabeth W. Jones Carol A. Woolford, Janelle A. Noble, J. Dauid Garman, Ming

Modulation of gelsolin function. Activation at low pH

Allen, Bertrand Y. Tuan, and Paul A. Janmey overrides Caa+ requirement. Jennifer A. Lamb, Philip G.

Structural and functional domains of the Drosophila ncd microtubule motor protein. Rashmi Chandra, Edward D. Salmon, Harold P. Erickson, Andrew Lockhart, and Sharyn A. Endow

The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp-2. 5”flanking sequence of lamp-2 gene and comparison of exon organization in two genes. Ritsuko Sawada, Kirsten A. Jardine, and Minoru Fukuda

Three-dimensional models of four mouse mast cell chy-

and protease-specific antigenic epitopes. Andrej tali, mases. Identification of proteoglycan binding regi ns

Ryoji Matsumoto, H. Patrick McNeil, Martin Karplus, and Richard L. Stevens

Xa inhibitory activities of antithrombin-I11 by muta- Dissociation of heparin-dependent thrombin and factor

tions in the reactive site. Henri J. M. Theunissen, Rein Dijkemn, Peter D. J. Grootenhu?, Joop C. Swinkels, Tom L. de Poorter, Peter Carati, and Arle Vtsser

Polarized secretion of thrombospondin is opposite to thyroglobulin in thyroid epithelial cells. Daniel Prabak- aran, Paul Kim, Kyung-Rae Kim, and Peter Arvan

Molecular cloning of human prostaglandin endoperox- ide synthase type 11 and demonstration of expression in response to cytokines. Dauid A. Jones, Dauid P. Carlton,

Prescott Thomas M. Mclntyre, Guy A. Zimmermnn, and Stephen M.

Purification and characterization of a multiprotein component of the Drosophila 26 S (1500 kDa) proteo- lytic complex. Andor Udvardy

Fpg protein of Escherichia coli is a zinc finger protein whose cysteine residues have a structural and/or func- tional role. Timothy R. O’Connor, Robert J . Graues, Gilbert de Murcia, Bertrand Castaing, and Jacques Laual

Purification and characterization of a novel zinc-pro- teinase from cultures of Aerornonas hydrophila. Ariel G. h w y , Ursula V. Santer, Maciej Wieczorek, James K. Blodgett, Steven W. Jones, and John C. Cheronis

Structural dissection of the multidomain kininogens. Fine mapping of the target epitopes of antibodies inter- fering with their functional properties. Jorg Kaujmann, Martina Haasemann, Susanne Modrow, and Werner Muller-Ester1

Interleukin-6 activates and regulates transcription fac- tors of the interferon regulatory factor family in M1 cells. Sheila Harroch, Yael Gothelf, Nobumasa W a t a d e , Michel Revel, and Judith Chebath

Cell-free repair of UV-damaged simian virus 40 chro-

cell-free system detecting excision repair of UV-irra- mosomes in human cell extracts. I. Development of a

diated SV40 chromosomes. Kaoru Sugasawa, Chikahide Masutani, and Fumio H a w k

Cell-free repair of UV-damaged simian virus 40 chro- mosomes in human cell extracts. 11. Defective DNA repair synthesis by xeroderma pigmentosum cell ex- tracts. Chikahide Masutani, Kaoru Sugasawa, Hiroshi Asa- hina, Kiyoji Tanaka, and Fumio Hanaokn

vii

9143 Purification and characterization of Caa+/calmodulin-

Mochizuki, ‘IPadashi Ita, and Hiroyoshi Hidaka dependent rotein kinase V from rat cerebrum. Hide0

9148 Transcriptional activation of the inducible nuclear receptor gene nur77 by nerve growth factor and mem- brane de olarization in PC12 cells. Jeong Kyo Yoon and Lester F. &u

ADDITIONS AND CORRECTIONS 9156 Insulin and insulinomimetic agents induce activation of

phosphatidylinositol 3”kinase upon its association withpp 185 (IRS-1) in intact rat livers. Vol. 267 (1992) 17483-17486. Yaron R. Hadan , EMad Tzahar, Orna Nadrv, Pau l Rothenberg, Charles T. Roberts, Jr., Derek LeRoith, Yosef Yarden, and Yehzel Ztck

9156 Molecular characterization of four pharmacologically distinct y-aminobutyric acid trans orters in .mouse brain,. Vol. 268 (1993) 2106-2112. % j n g - R ~ x L ~ u , Bea- trtz Lopez-Corcuera, Sreekala Mandtyan, annnh elson, and Nathan Nelson

9156 A retinoic acid-inducible mRNA from human erythro- leukemia cells encodes a novel tissue transglutaminase homologue. Vol. 267 (1992) 22616-22623. Bassam M.

N. Lee, and Robert A. Gonzaks Frag, Pau l J. Birckbichler, Manford K. Patterson, Jr., Kyung

xv Cumulative author index. Numbers 1 through 12.

9110 Characterization of lysosomes isolated from Dictyo- etelium diecoideum by magnetic fractionation. Juan M. Rodriguez-Paris, Kathleen V. Nolta, and Theodore L. Steck

9117 Dahl’s salt-resistant normotensive rat has mutations in

sive rat does not. Naomichi Matsuknwq Yasuki Nonaka, cytochrome P450(118), but the salt-sensitive hyperten-

Jitsuo Higaki, Masahiro Nagano, Hiroshi Mikami, Toshio Ogi- hara, and Mitsuhiro Okamoto

9122 Functional divergence of protein kinase C (PKC) family members. PKCr differs from PKCa and -811 and nPKCc in its competence to mediate 12-0-tetradecanoyl phor- bo1 13-acetate (TPA)-responsive transcriptional acti- vation through a TPA-response element. Akikn Hata, Yoshiko Akita, Koichi Suzuki, and Shigeo Ohm

9130 Isolation and characterization of rat CYPllB genes involved in late steps of mineralo- and glucocorticoid

and Yuzuru Ishimura syntheses. Kuniuki Mukai, Michiyo Imai, Hideo Shimada,

9138 Human eosinophil cytotoxicity-enhancing factor. Eo-

biosynthetic (recombinant) species with COOH-termi- sinophil-stimulating and dithiol reductase activities of

Marjorie S. Minkoff* and M. Katarzyna Balcewicz-Sablinska nal deletions. David S. Silberstein, Stephen McDonough,

GENERAL INFORMATION

your subscription ugent or contuct: THE JOURNAL OF BIOLOGICAL CHEMISTRY, This publication is available on CD-ROM. Inquire about availability through

428 EAST PRESTON STREET, BALTIMORE, MD 21202, U.S.A. Minireviews are reprinted in January of the succeeding year in a Minireoiew Compendium.

ASBMB Office, 9650 Rockville Pike, Bethesda, MD 20814, U.S.A. Compendia for 1988 through 1992 are available through the ASBMB office:

Submit all manuscripts in triplicate to Editor, The J o u r n a l of Biological Chemistry

Bethesda, MD 20814, U.S.A. 9650 Rockville Pike

the author(s) will pay a charge per page. Current page charges may be obtained Accepted manuscripts will he published with the implicit understanding that

by contacting the JBC Office. Under exceptional circumstances, when no source of grant or other support exists, the author(s) may apply, at the t ime of submission, for a grant-in-aid to Chairman, Publications Committee, Ameri- can Society for Biochemistry and Molecular Biology, Inc., 9650 Rockville Pike, Bethesda, MD 20814. All such applications must be countersigned by an appropriate institutional official stating that no funds are available for page charges.

Queries on matters of general editorial policy, requests for reprints of the “Instructions to Authors,” or of the “Editorial Policy and Practices,” or for permission to reproduce any part of a previously published article should be directed to the Journal Editorial Office in Bethesda, telephone 301-530-7150.

topics of interest to biochemists. The views expressed are those of the author(s) The Journal of Biological Chemistry publishes papers on a broad range of

and not of The Journal of Biological Chemistry or the American Society for Biochemistry and Molecular Biology.

for Biochemistry and Molecular Biology, fnc. Reprographic copying beyond The Journal of Biologrcal Chemistry is co yrighted by the American Society

that permitted by Sections 107 or 108 of the US. Copyright Law is allowed, provided that the $2.50 per-copy fee is paid through the Copyright Clearance Center, 27 Congress Street, Salem, MA 01970. For those organizations that have been granted photocopy license by CCC, a separate system of payment has been arranged. The fee code for users of the Transactional Reporting Service is: 0021-9258/93/$2.50. @ Printed on acid-free paper effective with Volume 254, Issue No. 1 (1979). Reproduction of any portion of an article for subsequent republication requires permission of the copyright owner. Requests should be made in writing to the American Society for Biochemistry and Molecular Biology, Inc., Attn.: Editorial Office, 9650 Rockville Pike, Bethesda, MD 20814, and should include a statement of intended use as well as explicit specifications of the material to be reproduced.

copies to: THE JOURNAL OF BIOLOGICAL CHEMISTRY, 428 EAST PRESTON Address all correspondence and orders relative to subscriptions and back

STREET, BALTIMORE, MD 21202, U.S.A., telephone 410-528-4255. Subscrip-

subscriptions will he honored with proportional refunds less a $10 cancellation tions are entered on a calendar year basis only. Requests for termination of

charge. Allow at least six weeks for address changes. Claims for replacement copies must be received within four nionths of the issue date.

Vol. 268, No. 12 The Journal of Biological Chemistry

CONTENTS Arranged by Subject Categories

April 25, 1993

8383

8569

08398

08406

6410

'8414

-8425

8458

8491

8497

8514

8521

8632

8640

8651

8683

8692

MINIREVIEW The anaerobic ribonucleotide reductase from Esche- richia coli. Peter Reichard

CARBOHYDRATES, LIPIDS, AND OTHER NATURAL PRODUCTS

Cholesterol loading of macrophages leads to marked enhancement of native lipoprotein(a) and apoprotein(a)

A. Keesler, Gunther M. Fless, and Ira Tabas internalization and degradation. Lori A. Bottalico, George

CELL BIOLOGY AND METABOLISM Phosphorylation of mitogen-activated protein kinases

ester, but not in the thyrotropin/cAMP, thyroid mito- is involved in the epidermal growth factor and phorbol

genic pathway. Frawoise Lamy, Franfoise Wilkin, Mireille Baptist, James Posada, Pierre P. Roger, and Jacques E. Dumont

Calcium-dependent cyclosporin A-sensitive activation of the interleukin-2 promoter by ~56'"'. Cosima T . Bal- dari, Adriana Heguy, and John L. Teljord

Endothelial nitric oxide synthase. N-terminal myris- toylation determines subcellular localization. Liliana Busconi and Thomas Michel

Reconstitution of the response to leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in hepatoma cells. Heinz Baurnann, Steven F. Ziegler, Bruce Mosley, Karen K. Morella, Sanja Pajouic, and Dauid P. Gearing

ing negative feedback by protein kinase C. Gary St. J. Sinusoidal oscillations in intracellular calcium requir-

Jr. Bird, Michel F. Rossier, Johnny F. Obie, and James W. Putney,

PACE/furin can process the vitamin K-dependent pro-

Louise C. Wasley, Alnawaz Rehemtulla, J. Andrew Bristol, and factor IX precursor within the secretory pathway.

Randal J . Kaujman

Guanine nucleotides activate multiple signaling path- ways in permeabilized gastric chief cells. Evidence for GTPyS-induced calcium-independent pepsinogen se- cretion. Robert D. Rajjaniello and Jean-Pierre Raufman

Inhibition of apolipoprotein E degradation in a post- Golgi compartment by a cysteine protease inhibitor. Shui Q. Ye, Catherine A. Reardon, and Godfrey S. Getz

Kinetics of GLUT1 and GLUT4 glucose transporters expressed inXenopus Oocytes. Harm Nishimura, Federico

and Morris J. Birnbaum V. Pallardo, Glen A. Seidner, Susan Vannucci, Ian A. Simpson,

Characterization of transferrin-independent iron

dence for multiple pathways of iron uptake. Robin S. transport in K562 cells. Unique properties provide evi-

Inman and Marianne Wessling-Resnick

Role of protein phosphorylation and dephosphorylation

ent Na+/H+ antiport. Heline Guizouarn, Franck Borgese, in activation and desensitization of the CAMP-depend-

Bernard Pellissier, Federico Garcia-Romeu, and Rene Motais

A novel K+ current inhibited by adrenocorticotropic hormone and angiotensin 11 in adrenal cortical cells. Boris Mlinar, Bruce A. Biagi, and John J. Enyeart

VLA-3 in cell adhesion, spreading, and homotypic cell The function and distinctive regulation of the integrin

aggregation. Jonathan B. Weitzman, Renata Pasqualini, Yoshikazu Takada, and Martin E. Hemler

Nucleotide binding to actin. Cation dependence of nu- cleotide dissociation and exchange rates. Henry J. Kin- osian, Lynn A. Selden, James E. Estes, and Lewis C. Gershman

G protein-mediated inhibition of phospholipase C activ- ity in a solubilized membrane preparation. Irene Litosch, Inna Sulkholutskuya, and Cong Weng

8752

8787

885 1

8871

8927

8958

8965

8980

9005

9041

9055

9110

9122

9130

9156

-8391

8429

Dityrosine and tyrosine oxidation products are endog- enous markers for the selective proteolysis of oxida- tively modified red blood cell hemoglobin by (the 19 S) proteasome. Cecilia Giuliui and Kelvin J. A. Dauies

ADP induces inositol phosphate-independent intracel- lular Caz+ mobilization in brain capillary endothelial cells. Christian Frelin, Jean Philippe Breittmayer, and Paul Vigne

Calcium: a mediator of the cellular response to chronic Na+/K+-ATPase inhibition. Barbara M. Rayson

Identification of a novel cyclin-like protein in human tumor cells. Richard T. Williams, Lingtao Wu, Denise A. Carbonaro-Hall, Vernon T. Tolo, and Frederick L. Hall

Platelet-derived growth factor stimulates a biphasic mobilization of arachidonic acid in Swiss 3T3 cells.

Rozengurt The role of phospholipase Az. Jan Domin and Enrique

CD45-associated kinase activity requires lclz but not T cell receptor expression in the Jurkat T cell line. Gary A. Koretzky, Mark Kohmetscher, and Susan Ross

Inhibition of the copper incorporation into ceruloplas- min leads to the deficiency in serum ceruloplasmin activity in Long-Evans Cinnamon mutant rat. Takahisa Yamada, Takashi Agui, Yasuo Suzuki, Mitsuru Sato, and Kozo Matsumoto

adrenergic stimulated CAMP accumulation in C6 Transfected Gola inhibits the calcium dependence of B-

Carrette, Rosalia Bertorelli, Ginette Le Cam, Oliuier Manzoni, glioma cells. Nathalie Charpentier, Laurent Prezeau, Josiane

Joel Bockaert, and Vincent Homburger

Structural and functional domains of the Drosophila ncd microtubule motor protein. Rashmi Chandra, Edward

A. Endow D. Salmon, Harold P. Erickson, Andrew Lockhart, and Sharyn

Polarized secretion of thrombospondin is opposite to thyroglobulin in thyroid epithelial cells. Daniel Prabak- aran, Paul Kim, Kyung-Rae Kim, and Peter Aruan

Purification and characterization of a multiprotein component of the Drosophila 26 S (1500 kDa) proteo- lytic complex. Andor Uduardy

Characterization of lysosomes isolated from Dictyo- stelium discoideum by magnetic fractionation. Juan M. Rodriguez-Paris, Kathleen V. Nolta, and Theodore L. Steck

Functional divergence of protein kinase C (PKC) family members. PKCy differs from PKCa and +I1 and nPKCc in its competence to mediate 12-0-tetradecanoyl phor- bo1 13-acetate (TPA)-responsive transcriptional acti- vation through a TPA-response element. Akiko Hata, Yoshiko Akita, Koichi Suzuki, and Shigeo Ohno

Isolation and characterization of ra t CYPllB genes involved in late steps of mineralo- and glucocorticoid syntheses. Kuniaki Mukui, Michiyo Imai, Hide0 Shimada, and Yuzuru Ishimura

Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3"kinase upon its association with pp 185 (IRS-1) in intact rat livers. Vol. 267 (1992)

Paul Rothenberg, Charles T. Roberts, Jr., Derek LeRoith, Yosef 17483-17486. Yaron R. Hadari, Eldad Tzahnr, Orna Nadlu,

Yarden, and Yehiel Zick

ENZYMOLOGY Phosphorylation and dephosphorylation catalyzed in

system, NarX and NarL. Margaret S. Walker and John A. vitro by purified components of the nitrate sensing

DeMoss

Hissea is the catalytically important histidyl residue of

zyme A reductase. Bryant G. Darnay and Victor W. Rodwell Syrian hamster 3-hydroxy-3-methylglutaryl-coen-

Indicates a Communication V l l l ...

ix

8480

8503

8507

8529

8590

8596

8624

8669

8717

8727

8735

8743

8769

8771

8781

8899

8972

8990

9071

Phosphatidic acid, lysophosphatidic acid, and lipid A are inhibitors of glycosylphosphatidylinositol-specific

by product analogues? Martin G. Low and Kuo-Sen H u n g phospholipase D. Specific inhibition of a phospholipase

Iodide as the mediator for the reductive reactions of peroxidases. Manish M. Shah and Steven D. A u t

Nucleotide binding properties of bovine brain uncoat- ing ATPase. Baochofig Gao, Yumiko Emoto, Lois Greene, and Evan Eisenberg

human poly(ADP-ribose) polymerase. Frederic Simonin, Identification of potential active-site residues in the

Olivier Poch, Marc Delarue, and Gilbert de Murcm

Isolation, sequence analysis, and cloning of haemadin. An anticoagulant peptide from the Indian leech. Karl-Hermann Strube, Burkhard Kroger, Siegfried Bialojan, Marcus Otte, and Johannes Dodt

Simultaneous binding of nitric oxide and isotopically

chuate 3,4-dioxygenase. Allen M. Orville and John D. labeled substrates or inhibitors by reduced protocate-

Lipscomb

The respiratory burst oxidase of human neutrophils. Guanine nucleotides and arachidonate regulate the as-

binant cell-free system. David J . Uhlinger, Shiv Raj Tyagi, sembly of a multicomponent complex in a semirecom-

K. Leigh Inge, and J . David Lambeth

Reversible palmitoylation of the protein-tyrosine ki- nase ~ 5 6 ~ ' . Lisa A. Paige, Monica J . S. Nadler, Marietta L. Harrison, John M. Cassady, and Robert L. Geahlen

Mutagenic analysis of AMP nucleosidase from Esche- richia coli. Deletion of a region similar to AMP deam- inase and peptide characterization by mass spectrome- try. Kalla Kualnes-Krick, James E. Labdon, Xiaoyan Ma, Edward Nieves, and Vern L. Schramm

Lysine 87 in the f l subunit of tryptophan synthase that forms an internal aldimine with pyridoxal phosphate

product release. Zichun Lu, Shinji Nagata, Peter McPhie, serves critical roles in transimination, catalysis, and

and Edith Wilson Miles

Characterization of the purified vitamin K-dependent y-glutamyl carboxylase. Daniel P. Morris, Berry A. M. Saute, Cees Vermeer, and Darrel W. Stafford

A kinetic analysis of RNA-dependent and DNA- Human immunodeficiency virus reverse transcriptase.

dependent DNA polymerization. John E. Reardon

Properties and regulation of the cell cycle-specific NIMA protein kinase of Aspergillus nidulans. Kun Ping Lu, Stephen A. Osmani, and Anthony R. Means

Arabidopsis ubiquitin-conjugating enzyme, AtUBCl+. Formation of a stable adduct between ubiquitin and the

Michael L. Sullivan and Richard D. Vierstra

erol transacylase from rat intestinal microsomes. Rich- Triacylglycerol synthesis by an sn-l,2(2,3)-diacylglyc-

ard Lehner and Arnis Kuksis

Regulation of G protein function by an effector in GTP- dependent signal transduction. An inhibitory subunit of cGMP phosphodiesterase inhibits GTP hydrolysis by transducin in vertebrate rod photoreceptors. Akio Ya- mazaki, Matsuyo Yamazaki, Seiji Tsuboi, Akio Kishigami, Kathryn 0. Umbarger, Lara D. Hutson, William T. Madland, and Fumw Hayashi

the PutA protein are coincident with reduction of its Conformational change and membrane association of

FAD cofactor by proline. Eric D. Brown and Janet M. Wood

Phenotypic analysis of proteinase A mutants. Implica- tions for autoactivation and the maturation pathway of the vacuolar hydrolases of Saccharomyces cereuisiae. Carol A. Woolford, Janelle A. Noble, J . David Garman, Ming F. Tam, Michael A. Znnis, and Elizabeth W. Jones

Purification and characterization of a novel zinc-pro- teinase from cultures of Aeromonas hydrophila. Ariel G. Loewy, Ursula V. Santer, Maciej Wieczorek, James K. Blodgett, Steven W. Jones, and John C. Cheronis

9117 Dahl's salt-resistant normotensive rat has mutations in cytochrome P450( 1 lfl), but the salt-sensitive hyperten- sive rat does not. Naomichi Matsukawa, Yasuki Nonaka, Jitsuo Higaki, Masahiro Nagana, Hiroshi Mikami, Toshw Ogi- hara, and Mitsuhiro Okamoto

9143 Purification and characterization of Caz+/calmodulin- dependent protein kinase V from rat cerebrum. Hide0 Mochizuki, Tadashi Ita, and Hiroyoshi Hidaka

MEMBRANES AND BIOENERGETICS 08387 The mitochondrial targeting presequence of the Rieske

iron-sulfur protein is processed in a single step after insertion into the cytochrome b c 1 complex in mammals

Linda Yu, Chnng-An Yu, and Bernard L. Trumpower and retained as a subunit in the complex. Ulrich Brandt,

4394 Phosphorylation and activation of the Ca2+-pumping ATPase of cardiac sarcoplasmic reticulum by Caz+/cal- modulin-dependent protein kinase. Ande Xu, Cynthia Hawkins, and Njanoor Narayanan

4418 A Na+-dependent creatine transporter in rabbit brain, muscle, heart, and kidney. cDNA cloning and func- tional expression. Ckcile Gulmbal and Manfred W. Kilimann

8536 Inhibition by tentoxin of cooperativity among nucleo- tide binding sites on chloroplast coupling factor 1. Ning- mei Hu, Denise A. Mills, Bernhard Huchzermeyer, and Mark L. Richter

8564 Thapsigargin causes Ca2+ release and collapse of the membrane potential of Trypanosoma brucei mitochon- dria in situ and of isolated rat liver mitochondria. Anibal E. Vercesi, Siluia N . J . Moreno, Celene F. Bernardes, Andre R. Meinicke, Eloise C. Fernandes, and Roberto Docampo

8760 Cas+-activated K* transport in erythrocytes. Compari- son of binding and transport inhibition by scorpion

Alper toxins. Carlo Brugnara, Lucia De Franceschi, and Seth L.

9156 Molecular characterization of four pharmacologically distinct y-aminobutyric acid transporters in mouse brain. Vol. 268 (1993) 2106-21 12. Qing-Rang Liu, Bea-

Nathan Nelson trlz Ldpez-Corcuera, Sreekala Mandlyan, Hannah Nelson, and

NUCLEIC ACIDS, PROTEIN SYNTHESIS, AND MOLECULAR GENETICS

-8422 Evolution of the type I1 hexokinase gene by duplication and fusion of the glucokinase gene with conservation of its organization. Kentaro Kogure, Yasuo Shinohara, and Hiroshi Terada

8466 Ionizing radiation induces expression of interleukin 6 by human fibroblasts involving activation of nuclear factor-KB. Marion Andrea Brach, Hans-Jiirgen GruJ, Tsuneyasu Kaisho, Yoshinobu Asano, Toshio Hiram, and Friedhelm Herrmann

8473 Pituitary-specific repression of placental members of the human growth hormone gene family. A possible mechanism for locus regulation. Mark W. Nachtigal, Bar- bara E. Nickel, and Peter A. Cattini

8541 Structure-function studies of yeast ferrochelatase.

substitutions that increase V,, and the K.,, for both Identification and functional analysis of amino acid

substrates. Abdelhamid Abbas and Rosine Labbe-Bois

8547 Distinct subdomains of human endothelin receptors de- termine their selectivity to endothelinA-selective antag- onist and endothelinB-selective agonists. Aiji Sakamoto, Masashi Yanugisawa, Tatsuya Sawamura, Taijiro Enoki, To- shio Ohtani, Takeshi Sakurai, Kazuwa Nakao, Teruhiko Toyo-oka, and Tomoh Masaki

8645 Determination of the DNA bend angle induced by the

Mg+. Tim0 Stover, Eleonore Kohler, Ursula Fagin, Wolfgang restriction endonuclease EcoRV in the presence of

Wende, Heiner Wolfes, and Alfred Pingoud

8665 Saccharomyces cerevisiae elongation factor 2. Muta- genesis of the histidine precursor of diphthamide yields a functional protein that is resistant to diphtheria toxin. Lon D. Phan, John P. Perentesis, and James W. Bodley

Indicates a Communication

X

8675

8793

8825

8835

8842

8855

8862

8881

8893

8908

8919

8943

8949

9014

9049

9092

9098

In organello footprinting. Analysis of protein binding

Steven C. Ghiuizzani, Cort S. Madsen, and William W . at regulatory regions in bovine mitochondrial DNA.

Hauswirth

Characterization of the human ADP-ribosylation fac- tor 3 promoter. Transcriptional regulation of a TATA- less promoter. Randy S. Haun, Joel Moss, and Martha Vaughn

Cloning of type XVII collagen. Complementary and genomic DNA sequences of mouse 180-kilodalton bul- lous pemphigoid antigen (BPAG2) predict an inter- rupted collagenous domain, a transmembrane segment, and unusual features in the 5’-end of the gene and the 3”untranslated region of the mRNA. Kehuu Li, Katsuto Tamai, Elaine M. L. Tan, and Jouni Uitto

Cloning of an inflammation-specific phosphatidyl ino- sitol-linked form of murine vascular cell adhesion mol- ecule- l. Pamela Moy, Roy Lobb, Richard Tizard, Dian Olson, and Catherine Hesswn

Molecular cloning and genomic organization of a gene for luciferin-binding protein from the dinoflagellate

Sczekan, David Morse, and J . Woodland Hastings Gonyaulax polyedra. Dong-Hee Lee, Maria Mittag, Steve

RNR-1, a nuclear receptor in the NGFI-BpJur77 fam- ily that is rapidly induced in regenerating liver. L. Marie Scearce, Thomas M. Laz, Thomas G. Hazel, Lester F. Lau, and Rebecca Taub

An enhancer for transcription of collagen IV genes is activated by F9 cell differentiation. Shizuko Tanakq Paul Kaytes, and Markku Kurkinen

Association of heterogeneous nuclear ribonucleopro- tein A 1 and C proteins with reiterated AUUUA se- quences. B. JoNell Hamilton, Eszter Nagy, James S. Maker, Bradley A. Arrick, and William F. C. Rigby

A basis for differentiating among the multiple human Mu-glutathione S-transferases and molecular cloning of brain GSTM5. Yasuo Takahashi, Eggerton A. Campbell, Yasuji Hirata, Tetsuji Takayama, and Irving Listowsky

DNA determinants of restriction. Bacteriophage T4 endonuclease 11-dependent cleavage of plasmid DNA in vivo. Karin Carlson, Margareta Krabbe, Anna-Chey Nystrbm, and Linda D. Kosturko

Biosynthesis of human fibrinogen. Subunit interactions and potential intermediates in the assembly. Shaoming Huang, Eileen R. Mulvihill, David H. Farrell, Dominic W. Chung, and Earl W. Davie

Interference by PR-bound RNA polymerase with PRM function in vitro. Modulation by the bacteriophage X CI protein. Pamela A. Hershberger, Barry C. Mita, Amporn Tripatara, and Pieter L. deHaseth

Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the Go state. Robert J . Pignolo, Vincent J. Cristofalo, and Mitch 0. Rotenberg

The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp-2. 5’-flanking sequence of lamp-2 gene and comparison of exon organization in two genes. Ritsuko Sawada, Kirsten A. Jardine, and Minoru Fukuda

Molecular cloning of human prostaglandin endoperox-

response to cytokines. David A . Jones, David P. Carlton, ide synthase type I1 and demonstration of expression in

Thomas M. Mclntyre, Guy A. Zzmmerman, and Stephen M. Prescott

Interleukin-6 activates and regulates transcription fac- tors of the interferon regulatory factor family in M1 cells. Sheila Harroch, Yael Gothelf, Nobumasa Watanube, Michel Revel, and Judzth Chebath

Cell-free repair of UV-damaged simian virus 40 chro- mosomes in human cell extracts. I. Development of a cell-free system detecting excision repair of UV-irra- diated SV40 chromosomes. Kaoru Sugasawa, Chrkahlde Masutani, and Fumro Hanaoka

9105

9148

9156

08402

8436

8447

8554

8574

8580

8608

8617

8658

8698

8704

8711

8801

8808

Cell-free repair of UV-damaged simian virus 40 chro-

repair synthesis by xeroderma pigmentmum cell ex- mosomes in human cell extracts. 11. Defective DNA

tracts. Chikahide Masutani, Kaoru Sugasawa, Hiroshi Asa- h im, Kiyoji Tanaka, and Fumw H a m k a

Transcriptional activation of the inducible nuclear

brane depolarization in PC12 cells. Jeong Kyo Yoon and receptor gene nur77 by nerve growth factor and mem-

Lester F. Lau

A retinoic acid-inducible mRNA from human erythro- leukemia cells encodes a novel tissue transglutaminase homologue. Vol. 267 (1992) 22616-22623. Bassam M. Fraij, Paul J . Birckbichler, Manford K. Patterson, Jr., Kyung N . Lee, and Robert A. Gonzales

PROTEIN CHEMISTRY AND STRUCTURE Specificity of Goodpasture autoantibodies for the re- combinant noncollagenous domains of human type IV collagen. Eric G. Neilson, Raghuram Kalluri, Mae Jane Sun, Sripad Gunwar, Theodore Danuff, Mariko Mariyama, Jeanne C. Myers, Stephen T. Reeders, and Billy G. H d o n

Domain structure and domain-domain interactions in human coagulation factor IX. Alezander Vysotchin, Leonid V. Medued, and Kenneth C. Ingham

Binding of lipoprotein lipase to heparin. Identification of five critical residues in two distinct segments of the amino-terminal domain. Akira Hata, David N. Ridinger,

Myers, Kuishu Ren, Tong Cheng, Ituro Inoue, Dana E. Wilson, Steve Sutherland, Mitsuru Emi, Zhang Shuhua, Richard L.

Per-Henrik Iverius, and Jean-Marc La loue l

Heme coordination of prostaglandin H synthase. Ah-Lim

Harold E. Van Wart, and Graham Palmer Tsai, Richurd J . Kulmacz, Jinn-Shyan Wang, Yang Wang,

Fibrin affinity of urokinase-type plasminogen activa- tor. Evidence that Zna+ mediates strong and specific interaction of single-chain urokinase with fibrin. S. Shaukat Husain

‘H NMR-based determination of the three-dimensional structure of the human plasma fibronectin fragment containing inter-chain disulfide bonds. Leela Kar, Ching-San h i , Carl E. Wolff, David Nettesheim, Simon Sher- man, and Michael E. Johnson

The effect of activated protein C on fibrinolysis in cell-

of prothrombin activation. Laszlo Balzar and M ~ h u e l free plasma can be attributed specifically to attenuation

Nesheim

Identification of two hyaluronan-binding domains in the hyaluronan receptor RHAMM. Baihuu Yang, Liying Zhang, and Eva Ann Turley

Immunoaffinity purification and characterization of 7- aminobutyric acid (GABA)B receptor from bovine cer- ebral cortex. Hiroshl Nakayasu, Masao Nishikawa, Hiroshi Mizutanl, Hrroshr Ktmura, and Kinya Kuriyama

Phosphorylation of HIV-1 gag proteins by protein ki- nase C. Barry Burette, Gang Yu, and Ronald L. Felsted

Inhibitory properties of full-length and truncated re- combinant tissue factor pathway inhibitor (TFPI). Evi- dence that the third Kunitz-type domain of TFPI is not

complexes on cell surfaces. Taka oshi Hamamoto, Masak- essential for the inhibition of factor VIIa-tissue factor

C. Foster, and Walter Kisiel uni Yamamoto, Ole Nordfang, Jens d Litske Petersen, Donald

valent cross-link in the inter-a-inhibitor-related pro- Presence of the protein-glycosaminoglycan-protein CO-

teinase inhibitor heavy chain 2/bikunin. Jan J. Enghild, Guy Saluesen, Ida B. TMgersen, Zuzanu Valnickova, Salvatore V. Pizzo, and Stanley A. Hefta

ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl-terminal ADP-ribosylation factor do-

gale, Joel Moss, and Martha Vaughn main. Koichi Mishima, Mikako Tsuchiya, Maria S. Nightin-

Identification of a new cell adhesion motif in two ho- mologous peptides from the COOH-terminal cell bind- ing domain of human thrombospondin. Mznh D. Kosfeld and William A. Frazier

Indicates a Communication

xi

8815 Membrane binding kinetics of factor VI11 indicate a

Barbara C. Furie, and Gary E. Gilbert complex binding process. Catherine Bardelle, Bruce Furie,

8888 Cloning, expression, and characterization of Crypto- coccus neoformas dihydrofolate reductase. Worachart Sirawaraporn, Ming Cao, Daniel V. Santi, and Jeffrey C. Edman

8935 Structural analysis of the myoglobin reconstituted with

Noriyuki Igarashi, and Nobuo Tanaku iron porphine. Saburo Neya, Noriaki Funasaki, Takao Sato,

8999 Modulation of gelsolin function. Activation at low pH

Allen, Bertrand Y. Tuan, and Paul A. Janmey overrides Ca2+ requirement. Jennifer A. Lamb, Philip G.

9023 Three-dimensional models of four mouse mast cell chy- mases. Identification of proteoglycan binding regipns and protease-specific antigenic epitopes. Andrej Sali, Ryoji Matsumoto, H. Patrick McNeil, Martin Karplus, and Richard L. Stevens

9035 Dissociation of heparin-dependent thrombin and factor Xa inhibitory activities of antithrombin-I11 by muta-

Dijkema, Peter D. J. Grootenhuis, Joop C. Swinkels, Tom L. tions in the reactive site. Henri J. M. Theunissen, Rein

de Poorter, Peter Carati, and Arie Visser

9063 Fpg protein of Escherichia coli is a zinc finger protein whose cysteine residues have a structural and/or func-

de Murcia, Bertrand Castaing, and Jacques Laval tional role. Timothy R. O'Connor, Robert J. Graves, Gilbert

9079 Structural dissection of the multidomain kininogens. Fine mapping of the target epitopes of antibodies inter- fering with their functional properties. Jorg Kaufmann, Martina Haasemann, Susanne Modrow, and Werner Muller-Ester1

9138 Human eosinophil cytotoxicity-enhancing factor. Eo-

biosynthetic (recombinant) species with COOH-termi- sinophil-stimulating and dithiol reductase activities of

Marjorie S. Minkoff, and M. Katarzyna Balcewicz-Sablinska nal deletions. David S. Silberstein, Stephen McDonough,

Abbas, Abdelhamid, 8541 Ami, Takashi, 8965 Akita, Yoshiko, 9122 Allen, Philip G., 8999 Alper, Seth L., 8760 Arrick, Bradley A,, 8881 Arvan, Peter, 9041 Asahina, Hiroshi, 9105 Asano, Yoshinobu, 8466 Aust, Steven D., 8503 Bajzar, Laszlo, 8608 Balcewicz-Sablinska, M.

Baldari, Cosima T., 8406 Katarzyna, 9138

Baptist, Mireille, 8398 Bardelle, Catherine, 8815 Baumann, Heinz, 8414 Bernardes, Celene F., 8564 Bertorelli, Rosalia, 8980 Biagi, Bruce A., 8640 Bialojan, Siegfried, 8590 Birckbichler, Paul J., 9156 Bird, Gary St. J., 8425 Birnbaum, Morris J., 8514 Blodgett, James K., 9071 Bockaert, Joel, 8980 Bodley, James W., 8665

Bottalico, Lori A,, 8569 Borgese, Franck, 8632

Brach, Marion Andrea, 8466 Brandt, Ulrich, 8387 Breittmayer, Jean Philippe,

Bristol, J. Andrew, 8458 Brown, Eric D., 8972 Brugnara, Carlo, 8760 Burnette, Barry, 8698 Busconi, Liliana, 8410 Campbell, Eggerton A., 8893

Carati, Peter, 9035 Cao, Ming, 8888

Carbonaro-Hall, Denise A,,

Carlson, Karin, 8908 Carlton, David P., 9049

Cassady, John M., 8669 Carrette, Josiane, 8980

Castaing, Bertrand, 9063 Cattini, Peter A., 8473 Chandra, Rashmi, 9005 Charpentier, Nathalie, 8980

Cheng, Tong, 8447 Chebath, Judith, 9092

Cheronis, John C., 9071 Chung, Dominic W., 8919 Cristofalo, Vincent J., 8949

8787

8871

Danoff, Theodore, 8402 Darnay, Bryant G., 8429 Davie, Earl W., 8919 Davies, Kelvin J. A,, 8752 De Franceschi, Lucia, 8760 deHaseth, Pieter L., 8943 Delarue, Marc, 8529 DeMoss, John A., 8391 de Murcia, Gilbert, 8529,

de Poorter, Tom L., 9035 Dijkema, Rein, 9035 Docampo, Roberto, 8564 Dodt, Johannes, 8590 Domin, Jan, 8927 Dumont, Jacques E., 8398 Edman, Jeffrey C., 8888 Eisenberg, Evan, 8507 Emi, Mitsuru, 8447 Emoto, Yumiko, 8507 Endow, Sharyn A,, 9005 Engbild, Jan J., 8711 Enoki, Taijiro, 8547 Enyeart, John J., 8640 Erickson, Harold P., 9005 Estes, James E., 8683 Fagin, Ursula, 8645 Farrell, David H., 8919 Felsted, Ronald L., 8698

Fless, Gunther M., 8569 Fernandes, Eloise C., 8564

Foster, Donald C., 8704 Fraij, Bassam M., 9156 Frazier, William A,, 8808 Frelin, Christian, 8787

Funasaki, Noriaki, 8935 Fukuda, Minoru, 9014

Furie, Bruce, 8815 Furie, Barbara C., 8815

Gao, Baochoiig, 8507 Garcia-Romeu, Federico,

Garman, J. David, 8990

Gearing, David P., 8414 Geahlen, Robert L., 8669

Getz, Godfrey S., 8497 Gershman, Lewis C., 8683

Gilbert, Gary E., 8815 Ghivizzani, Steven C., 8675

Gonzales, Robert A,, 9156 Giulivi, Cecilia, 8752

Gothelf, Yael, 9092 Graves, Robert J., 9063 Greene, Lois, 8507 Grootenhuis, Peter D. J.,

9063

8632

9035

AUTHOR INDEX

GNR, Hans-Jiirgen, 8466 Guimbal, Cicile, 8418 Guizouarn, HBlhne, 8632 Gunwar, Sripad, 8402 Haasemann, Martina, 9079 Hadari, Yaron R., 9156 Hall, Frederick L., 8871 Hamamoto, Takayoshi, 8704 Hamilton, B. JoNell, 8881 Hanaoka, Fumio, 9098,9105 Harrison, Marietta L., 8669 Harroch, Sheila, 9092 Hastings, J. Woodland, 8842 Hata, Akiko, 9122 Hata, Akira, 8447 Haun, Randy S., 8793 Hauswirth, William W., 8675 Hawkins, Cynthia, 8394 Hayashi, Fumio, 8899 Hazel, Thomas G., 8855 Hefta, Stanley A,, 8711 Heguy, Adriana, 8406 Hemler, Martin E., 8651

Hershberger, Pamela A,, 8943 Herrmann, Friedhelm, 8466

Hession, Catherine, 8835 Hidaka, Hiroyoshi, 9143

Hirano, Toshio, 8466 Higaki, Jitsuo, 9117

Hirata, Yasuji, 8893 Homburger, Vincent, 8980

Huang, Kuo-Sen, 8480 Hu, Ningmei, 8536

Huang, Shaoming, 8919 Huchzermeyer, Bernhard,

Hudson, Billy G., 8402 Husain, S. Shaukat, 8574 Hutson, Lara D., 8899 Igarashi, Noriyuki, 8935 Imai, Michiyo, 9130 Inge, K. Leigh, 8624 Ingham, Kenneth C., 8436

Innis, Michael A,, 8990 Inman, Robin S., 8521

Inoue, Ituro, 8447 Ishimura, Yuzuru, 9130

Iverius, Per-Henrik, 8447 Ito, Tadashi, 9143

Janmey, Paul A,, 8999 Jardine, Kirsten A,, 9014 Johnson, Michael E., 8580 Jones, David A,, 9049 Jones, Elizabeth W., 8990 Jones, Steven W., 9071

8536

Kaisho, Tsuneyasu, 8466 Kalluri, Raghuram, 8402 Kar, Leela, 8580 Karplus, Martin, 9023 Kaufman, Randal J., 8458 Kaufmann, Jorg, 9079 Kaytes, Paul, 8862 Keesler, George A., 8569 Kilimann, Manfred W., 8418 Kim, Kyung-Rae, 9041 Kim, Paul, 9041 Kimura, Hiroshi, 8658 Kinosian, Henry J., 8683 Kishigami, Akio, 8899 Kisiel, Walter, 8704 Kogure, Kentaro, 8422 Kohler, Eleonore, 8645 Kohmetscher, Mark, 8958 Koretzky, Gary A,, 8958 Kosfeld, Minh D., 8808 Kosturko, Linda D., 8908 Krahbe, Margareta, 8908 Kroger, Burkhard, 8590 Kuksis, Arnis, 8781 Kulmacz, Richard J., 8554 Kuriyama, Kinya, 8658 Kurkinen, Markku, 8862 Kvalnes-Krick, Kalla, 8717 Labbe-Bois, Rosine, 8541

Lai, Ching-San, 8580 Labdon, James E., 8717

Lalouel, Jean-Marc, 8447 Lamb, Jennifer A,, 8999

Lamy, FranGoise, 8398 Lamheth, J. David, 8624

Lau, Lester F., 8855, 9148 Laval, Jacques, 9063

Le Cam, Ginette, 8980 Laz, Thomas M., 8855

Lee, Kyung N., 9156 Lee, Dong-Hee, 8842

Lehner, Richard, 8781 LeRoith, Derek, 9156

Lipscomb, John D., 8596 Li, Kehua, 8825

Listowsky, Irving, 8893 Litosch, Irene, 8692 Liu, Qing-Rong, 9156 Lobb, Roy, 8835 Lockhart, Andrew, 9005 Loewy, Ariel G., 9071 L6pez-Corcuera, Beatriz,

Lu, Kun Ping, 8769 Low, Martin G., 8480

Lu, Zichun, 8727

9156

Ma, Xiaoyan, 8717 Madland, William T., 8899 Madsen, Cort S., 8675 Malter, James S., 8881 Mandiyan, Sreekala, 9156 Manzoni, Olivier, 8980 Mariyama, Mariko, 8402 Masaki, Tomoh, 8547 Masutani, Chikahide, 9098,

Matsukawa, Naomichi, 9117 Matsumoto, Kozo, 8965 Matsumoto, Ryoji, 9023 McDonough, Stephen, 9138 McIntyre, Thomas M., 9049 McNeil, H. Patrick, 9023 McPhie, Peter, 8727 Means, Anthony R., 8769 Medved, Leonid V., 8436 Meinicke, Andre R., 8564 Michel, Thomas, 8410

Miles, Edith Wilson, 8727 Mikami, Hiroshi, 9117

Mills, Denise A., 8536 Minkoff, Marjorie S., 9138 Mishima, Koichi, 8801 Mita, Barry C., 8943 Mittag, Maria, 8842 Mizutani, Hiroshi, 8658 Mlinar, Boris, 8640 Mochizuki, Hideo, 9143 Modrow, Susanne, 9079 Morella, Karen K., 8414 Moreno, Silvia N. J., 8564 Morris, Daniel P., 8735 Morse, David, 8842 Mosley, Bruce, 8414 Moss, Joel, 8793,8801 Motais, Reni, 8632 Moy, Pamela, 8835 Mukai, Kuniaki, 9130 Muller-Ester], Werner, 9079 Mulvihill, Eileen R., 8919 Myers, Jeanne C., 8402 Myers, Richard L., 8447

Nachtigal, Mark W., 8473 Nadiv, Orna, 9156 Nadler, Monica J. S., 8669 Nagano, Masahiro, 9117 Nagata, Shinji, 8727 Nagy, Eszter, 8881 Nakao, Kazuwa, 8547 Nakayasu, Hiroshi, 8658 Narayanan, Njanoor, 8394 Neilson, Eric G., 8402 Nelson, Hannah, 9156 Nelson, Nathan, 9156

9105