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Orochem has manufactured high quality Sample Preparation products, Chromatography Columns, Protein Research products, and High Throughput Sample Preparation devices for over 22 years in the United States. These products and technologies have been used globally by many Fortune 500 Companies. Orochem provides end-to-end services from customer product design to method development. Single Source 22 Years of Manufacturing in USA ISO 9001:2008 Vacuum Manifolds PSP UHPLC / HPLC Columns Guard Cartridges Evaporators Urine Analysis & Blood Analysis Contract Services & OEM Provider Orochem Sample Prep Products Polymeric SPE Silica Based SPE Protein Crash Plate Phospholipid Depletion Plate Affinity Purification Products Desalting Products MANUFACTURING IN USA SINCE 1996 ISO 9001:2008 Evaporators 6 and 12 channels for tubes and vials 1 & 2 plate formats Heated both top and bottom Robotic Liquid Handling Systems Several systems with different plate nests For 96- and 384-well plates Maximum channel volumes range from 125-1000 uL Format compatible with PSP For Free Consultation, Please Enquire: Dr. Anil Oroskar, PhD Dr. Asha Oroskar, PhD Tel: 630 210 8300 [email protected] www.orochem.com Distributors Orochem Offices Legend

22 Years of Manufacturing in USA Legend ISO 9001:2008Phospholipid Depletion Plate Affinity Purification Products Desalting Products MANUFACTURING IN USA SINCE 1996 ISO 9001:2008 Evaporators

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Page 1: 22 Years of Manufacturing in USA Legend ISO 9001:2008Phospholipid Depletion Plate Affinity Purification Products Desalting Products MANUFACTURING IN USA SINCE 1996 ISO 9001:2008 Evaporators

Orochem has manufactured high quality Sample Preparation products, Chromatography Columns, Protein Researchproducts, and High Throughput Sample Preparation devices for over 22 years in the United States. These productsand technologies have been used globally by many Fortune 500 Companies.

Orochem provides end-to-end services from customer product design to method development.

Single Source

22 Years ofManufacturing

in USAISO 9001:2008

Vacuum Manifolds

PSP

UHPLC / HPLC ColumnsGuard Cartridges

Evaporators

Urine Analysis &Blood Analysis

ContractServices &OEM Provider

Orochem Sample PrepProducts

Polymeric SPESilica Based SPEProtein Crash PlatePhospholipid Depletion PlateAffinity Purification ProductsDesalting Products

MANUFACTURING IN USA SINCE 1996ISO 9001:2008

Evaporators

6 and 12 channels for tubes and vials

1 & 2 plate formats

Heated both top and bottom

1 & 2 plate formats

Heated both top and bottom

Robotic Liquid Handling Systems

Several systems with different plate nests

For 96- and 384-well plates

Maximum channel volumes range from 125-1000 uL

Format compatible with PSP Format compatible with PSP

For Free Consultation,Please Enquire:Dr. Anil Oroskar, PhDDr. Asha Oroskar, PhD

Tel: 630 210 [email protected]

Distributors

Orochem Offices

Legend

Page 2: 22 Years of Manufacturing in USA Legend ISO 9001:2008Phospholipid Depletion Plate Affinity Purification Products Desalting Products MANUFACTURING IN USA SINCE 1996 ISO 9001:2008 Evaporators

Sample Preparation Products:Sample Preparation Products: Solid Phase Extraction Products:Solid Phase Extraction Products:

High Throughput Filtration Products

Oro-flex polypropylene filter plate with 10 and20 µm PE frits.

Excellent for dilute and shoot mass spectrometry methods and high throughput screening applications.

Both hydrophobic and hydrophilic membranes.

0.2 and 0.45 micron filters

Protein Crash Plate

Orochem manufactured the 1st protein crash plate in the industry.

0.2 and 0.45 micron filters

Matrikleen Extraction Products

New generation of phospholipid and protein removal plate.

Patents 2016, and has been adapted by a Mayo Clinic Lab for routine analysis.

Key application: Vitamin D metabolites in plasma and serum.

Both hydrophobic and hydrophilic membranes.

Orochem manufactured the

0.2 and 0.45 micron filters

Patents 2016, and has been adapted by a Mayo

Key application: Vitamin D metabolites in plasma

OroQ QuEChERS Dispersive Products

For AOAC methods

Orochem specialty for tea, green leaves, fruits, stevia and hemp.

For AOAC methods

SLLE Products

Various sample sizes for clinical diagnostics labs.

Key application: cortisone extractions from plasma.

Various sample sizes for clinical diagnostics labs.

Key application: cortisone extractions from plasma.

Silica Based SPE Products

Normal, Reversed and Ion-exchange Phases

Alumina Based SPE Products

Neutral, Acid, and Basic Phases

Normal, Reversed and Io

Polymer Based SPE Products

Reversed Phases:

Celerity Deluxe products have been the major polymeric SPE products in global CROs for years.

Panthera Deluxe is the new generation. It has been quickly adopted by CROs.

Higher performance and affordable

Applications:

Topiramate

Pregabalin

Dolutegravir

Dapagliflozine

Ibuprofen

Loratidine

Bile Acids

Paliperidon

Chlorozoxazone

Isosorbide mononitrate

Amphetamines

Benzodiazepines

Opiates

Recreational drugs

Dolutegravir

Lamivudine

Gefitinib

Tenofovir

Sofosbeuvir

Hydroxychloroquine

Amphotericine B Liposomal

Dapagliflozine

Doxorubicin

Saxagliptin

Memantine

Amphotericin

Nitrofurantoin

Reloxifene

Albendazole

Pramipexole

BUPIVACAINE Liposomal

96-Well(rimless long lure)

24-Well

48-Well

OF 1100Microelution Paliperidon

Chlorozoxazone

Isosorbide mononitrateHydroxychloroquine

Amphotericine B Liposomal

Albendazole

Pramipexole

BUPIVACAINE Liposomal

Ion-exchanged Phases:Agility SCX, SAX, WAX,WCX

Page 3: 22 Years of Manufacturing in USA Legend ISO 9001:2008Phospholipid Depletion Plate Affinity Purification Products Desalting Products MANUFACTURING IN USA SINCE 1996 ISO 9001:2008 Evaporators

Legacy Phases HPLC Columns

General Utility:

Reliasil Column

Phases: Silica, C1, C4, C8, C18, C30, NH2, CN, Phenyl, SCX, SAX, Diol, Polyamine, PFP.

pH Range: 2-8.5

C% Loading: 9

Chromatography Products:Chromatography Products: Chromatography Products:Chromatography Products:

Reliasil Column

Phases: Silica, C1, C4, C8, C18, C30, NH2, CN, Phenyl, SCX, SAX, Diol, Polyamine, PFP.

Separation of Polar, Semi-Polar, and Nonpolar Compounds at Low to Medium pH

Orosil Column: Orosil C18 Column is used worldwide for analyzing azacitidine and impurities,

as drafted in a USP method.

Phases: C8, C18

pH Range: 1.5-9.0

C% Loading: 17

Phases: C8, C18

C% Loading: 17

Analysis of Basic Compounds and Highly Polar Compounds:

Prestige and Matrix Columns are highly base-deactivated stationary phases.

Phases: C8, C18, Matrix AQ

pH Range: 2-8.5

C% Loading: 16

Phases: C8, C18, Matrix AQ

For Challenging Pharmaceutical and Peptide Separations:

Monitor Columns: Orochem’s top quality columns

Phases: Silica, C8, C18

pH Range: 2-8

C% Loading: 17

Monitor Columns: Orochem’s top quality columns

Phases: Silica, C8, C18

pH Range:

C% Loading: 17

Chiral Phases HPLC Columns

Epitomize Chiral Columns

Polysaccharide-based chiral station

Coated and covalently-bound

Particle Size: 1.7, 3.5, 10 micron

Chiral library for over 50 compounds

UHPLC Columns

Gazelle UHPLC Columns

C18, Biphenyl, Amino

Particle Size: 1.7 micron

Key applications: Amphetamines, Benzodiazepines, Opiates, Recreational Drugs.

C18, Biphenyl, Amino

Guard Cartridges for HPLC and UHPLC Columns

Various dimensions

Legacy phases, Chiral phases, and UHPLC phases Legacy phases, Chiral phases, and UHPLC phases

Quick Disconnected Columns

Reusable column hardware and orpheus sorbents

Key applications: Desalting and online Solid Phase Extraction

Chromatography Products:Chromatography Products:Chromatography Products:Chromatography Products:Chromatography Products:

Key applications: Amphetamines, Benzodiazepines, Opiates, Recreational Drugs.

EZY Flash Columns

Lure-lock connections compatible with most Flash Chromatography systems

Leak free up to 150 psi

Proprietary dry packing procedure

Pre-packed with Orochem manufactured stationary phases

Phases: Normal Phases (Si, Al, Al-acid, Al-basic), Reversed Phases (C18, C8), and Ion-exchange Phases

40-60 microns irregular or spherical 50 microns

Lur

Proprietary dry packing procedure

Pr Pr

Phases: Normal Phases (Si, Al, A

4

acid, Al-basic), Reversed Phases (C18, C8), and Ion-exchange Phases

Key applications: Amphetamines, Benzodiazepines, Opiates, Recreational Drugs.

Reusable column hardware and orpheus sorbents

Key applications: Desalting and online Solid Phase Extraction

Page 4: 22 Years of Manufacturing in USA Legend ISO 9001:2008Phospholipid Depletion Plate Affinity Purification Products Desalting Products MANUFACTURING IN USA SINCE 1996 ISO 9001:2008 Evaporators

Coral Desalting Column and Plate

High protein recovery/high small molecule retention

Reva detergent removal products

Low non-specific protein/peptide binding resin maximizes protein/peptide recovery

Protein Research Products:Protein Research Products:

Positive Pressure Processor

48, 96, and 144 cartridge formats

One and two plate formats

Affinity Purification Products

1. EZ Link Resin

Efficient immobilization of antibodies, peptides, proteins and other biomolecules to create affinity supports

2. EZ Pure Protein A Resin

High capacity (>34 mg human IgG/ml ) resin, leach resistant, multiple uses without decline in yield

3. EZ Pure Protein G Resin

High capacity (>30mg human IgG/ml) resin ideal for mouse IgG1 and human IgG3 isotypes

4. EZ Pure Streptavidin Resin

Streptavidin is immobilized by charge free, leach resistant covalent bonds, low non-specific binding

Ideal for purification and isolation of biotinylated bio molecules

5. EZ Pure Ni-NTA Resin

High capacity (60mg His-tag protein/ml) resin for purifying recombinant protein carrying a His-tag

6. EZ Pure Cobalt Resin

High performance affinity resin for obtaining high-purity his-tagged fusion proteins from cell lysates under native and denaturing conditions

7. EZ Pure Glutathione Resin

High capacity (40 mg GST protein/ml) resin to purify GST fusion proteins from bacterial lysates

High capacity (>30mg human IgG/ml) resin ideal for mouse IgG1 and human IgG3 isotypes

Ideal for purification and isolation of biotinylated bio molecules

48, 96, and 144 cartridge formats

One and two plate formats

Vacuum Manifold

12- and 24-position cartridge formats

Plate format

High throughput lab process automation:High throughput lab process automation: