2020 MSKCARDIO-ONCOLOGY SYMPOSIUM

MAY 15-16, 2020 NEW YORK CITY

Memorial Sloan Kettering Cancer CenterRockefeller Research Laboratories

Optional Networking Reception Optional Computer Based Learning Lab Live Simulcast Available

mskcc.org/cardio-onc

2020 Program Highlights

An Up-to-Date Overview of:

• Cancer concepts for the non-oncologists:• Pharmacotherapy of cancer drugs - mechanism of

action and how it causes cardiotoxicity: anthracycline, anti-HER2, VEGF and immunotherapy

• Radiation therapy basics: types of radiation therapy, role in cancer treatment - mechanism of action and mechanism of cardiotoxicity

• Immunotherapy/check-point inhibitor induced myocarditis - diagnosis and management.

• Breast cancer treatment and heart disease - what we know, what we don’t know and what we need to know.

• Cardiac amyloidosis - contemporary approach to diagnosis and advances in treatment with novel therapies.

• Incorporating guidelines into clinical practice.• Cardiac imaging in clinical decision making - which modality,

how often and which patient? Hands-on workshop on GLS measurement by 2D STE.

• Essentials for managing adult survivors of childhood cancer.• Anticoagulation in cancer.• Mitigating adverse cardiac effects of cancer treatment –

role of cardioprotective drugs, exercise, dexrazoxane.• Emerging new therapy - CART T cell and associated CV

manifestation.• Clinical Challenges in Cardio-Oncology: 5FU induced CP, CV

issues in bone marrow transplant, management of radiation induced heart disease, autonomic dysfunction, arrhythmia management, cardiac surgery and interventional cardiology for management of CAD and valvular heart disease.

Complimentary Networking Reception

Course attendees are invited to an optional networking reception on Friday evening, which will provide an opportunity to meet and interact with the course faculty and get to know other members in the cardio-oncology community.

Modern cancer therapy has significantly improved cancer survival, transforming several once-fatal cancers into chronic disease, but often at the expense of exposure to cardiotoxic drugs. Cardiovascular disease is now a leading cause of morbidity and mortality in cancer survivors as they are living long enough to experience later onset cardiac effects of these treatments. Cardio-oncology is a rapidly evolving field comprised of multidisciplinary care teams focused on improving the outcome of patients with cancer.

The purpose of this conference is to provide a state-of-the-art, comprehensive, case-based curriculum that addresses important clinical topics relevant to the cardiovascular health of patients with cancer. Clinical experts from Memorial Sloan Kettering Cancer Center and around the country will present an up-to-date overview on cutting edge cancer therapies and best practice strategies in cardiovascular care in cancer patients including preventive strategies, early diagnosis and treatment and long-term surveillance.

All presentations will include devoted time for interaction between audience members and presenters.

Optional Echocardiography Learning LabSaturday, May 16, 4:15-6:30 pm

There will be an optional Computer Based Learning Lab, which will provide participants a personalized hands-on experience in Global Longitudinal Strain (GLS) performance and analysis.

The Cardio-Oncology Symposium (Fri.-Sat.) and the Learning Lab (Sat.) can be registered for separately. Discount available when you register for both.

Live Simulcast Available

Unable to attend this course in person? We are pleased to offer a live simulcast for the 2020 MSK Cardio-Oncology Symposium. CME and ABIM MOC credit is offered for the live simulcast and pre-registration is required. We do hope you will attend in person but understand that can sometimes be a challenge, so we are happy to offer the live simulcast as an option.

OVERVIEW

For more information or to register: mskcc.org/cardio-onc

Jennifer Liu, MDDirector, Cardiovascular LaboratoriesAttending PhysicianMemorial Sloan Kettering Cancer CenterAssociate Professor of MedicineWeill Cornell Medical College

Richard M. Steingart, MDChief, Cardiology Service Attending Physician,Memorial Sloan Kettering Cancer CenterProfessor of Medicine,Weill Cornell Medical College

Ellin Berman, MDLeukemia Service

Oren Cahlon, MD Radiation Oncology

Angel Chan, MD, PhDCardiology Service

Carol Chen, MD Cardiology Service

Chau Dang, MD Breast Oncology Service

Sergio Giralt, MDBone Marrow Transplant

Michelle Johnson, MD, MPH Cardiology Service

Heather Landau, MDBone Marrow Transplant

C. Ola Landgren, MD, PhDMyeloma Service

Miguel Perales, MD Bone Marrow Transplant

Michael Postow, MDMelanoma Service

Wendy Schaffer, MD, PhDCardiology Service

Susan Slovin, MD, PhDGU Oncology

Gerald Soff, MDBenign Hematology

Anthony Yu, MDCardiology Service

Course Directors

Memorial Sloan KetteringCourse Faculty

Invited Course Faculty

Faculty DisclosureIt is the policy of MSK to make every effort to insure balance, independence, objectivity, and scientific rigor in all continuing medical education activities which it provides as an ACCME accredited provider. In accordance with ACCME guidelines and standards, all faculty participating in an activity provided by MSK are expected to disclose any significant financial interest or other relationship with the manufacturer(s) of any commercial product(s) and/or provider(s) of commercial services which are discussed by the faculty members in an educational presentation. As required by the ACCME, when an unlabeled use of a commercial product or an investigational use not yet approved for any purpose is discussed during an educational activity, MSK requires the speaker to disclose that the product is not labeled for the use under discussion or that the product is still investigational.

Join the conversation: #MSKCardioOncCME

Gregory Armstrong, MD, MSCESt. Jude Children’s Research HospitalMemphis, TN

Usman Baber, MDMt. Sinai HospitalNew York, NY

Ana Barac, MD, PhDMedStar Washington Hospital CenterWashington DC

Ann Blaes, MDUniversity of MinnesotaMinneapolis, MN

Susan Dent, MDDuke UniversityDurham, NC

Milind Desai, MD Cleveland Clinic Cleveland, OH

Michael Fradley, MD University of South Florida Tampa, FL

Joerg Herrmann, MD Mayo Clinic Rochester, NY

James Ip, MD Weill Cornell Medical CenterNew York, NY

Bonnie Ky, MDUniversity of Pennsylvania Philadelphia, PA

Daniel Lenihan, MDWashington UniversitySt. Louis, MO

Mathew Maurer, MD Columbia Presbyterian Hospital New York, NY

Tomas Neilan, MD Massachusetts General Hospital Boston, MA

Anju Nohria, MD Brigham and Women’s Hospital Boston, MA

Marielle Scherrer-Crosbie, MD, PhDUniversity of PennsylvaniaPhiladelphia, PA

Sandra Swain, MDGeorgetown University Medical CenterWashington DC

Dinesh Thavendiranathan, MDToronto General HospitalToronto, Canada

Jonathan Weinsaft, MDWeill Cornell Medical CenterNew York, NY

SCHEDULE

7:00 am Breakfast and Registration 8:00 am Introduction and Welcome

Jennifer Liu, MD8:05 am Opening Remarks

Richard M. Steingart, MD

Plenary Lecture8:15 am Moving Cardio Oncology Forward:

My Journey in Navigating Patient’s Cancer Treatment Through CardiotoxicitySandra Swain, MD

Best Practice Strategies to Optimize Outcomes 8:45 am Clinical Paradigm for Modern Cancer Treatment:

Surgery, Systemic Therapy, Radiation – When, for Whom and Why? Ann Blaes, MD

9:05 am Cardio-Oncology Clinical Practice Guidelines: Key Take Home Messages Susan Dent, MD

9:25 am Q&A

Immunotherapy 9:35 am Immunotherapy: Understanding Antitumor Immunity and Moving the Field Forward

Michael Postow, MD9:55 am Immunotherapy Induced Myocarditis: Incidence, Screening and Diagnosis

Tomas Neilan, MD 10:15 am Management Strategies

Carol Chen, MD 10:35 pm Q&A10:50 pm Break 11:05 am Breast Cancer Treatment and CV Disease –

A Multi-specialty Collaborative Approach to ManagementChau Dang, MD and Anthony Yu, MD

11:45 am Q&A

Anticoagulation in Cancer12:00 pm Risk, Prevention and Treatment Algorithm in Cancer-associated Thrombosis

Gerald Soff, MD 12:25 pm Q&A12:35 pm Lunch Break

Cardiovascular Considerations in Hematologic Malignancies1:10 pm Understanding Stem Cell/Bone Marrow Transplant

Sergio Giralt, MD1:30 pm CV Issues and Challenges During and After Bone Marrow Transplant

Wendy Schaffer, MD PhD 1:50 pm Cardiovascular Care of Patients with CML on TKI Therapy

Joerg Herrmann, MD 2:10 pm Q&A

Amyloidosis and Multiple Myeloma: Contemporary Diagnosis and New Advances in Treatment

2:25 pm Cardiac Amyloidosis: When to Suspect and How to Make the Diagnosis? Jennifer Liu, MD

2:45 pm Contemporary Management of AL Amyloidosis Heather Landau, MD

3:05 pm ATTR Amyloidosis – Novel Treatment OptionsMathew Maurer, MD

Friday, May 15, 2020 3:25 pm Multiple Myeloma: Practice Essentials - Diagnosis and Treatment C. Ola Landgren, MD, PhD

3:45 pm Cardiac Management of Amyloid Cardiomyopathy and CV Considerations for Contemporary Multiple Myeloma TherapiesDaniel Lenihan, MD

4:05 pm Q&A4:25 pm Break

CV Disease and Cancer 4:40 pm 5-FU Induced Cardiotoxicity

Wendy Schaffer, MD, PhD5:00 pm Cardiovascular Effects of Androgen Deprivation Therapy in Prostate Cancer Patients

Susan Slovin, MD, PhD5:20 pm Q&A5:30 pm Adjourn

Complimentary Networking Reception (Optional) Course attendees are invited to a complimentary networking reception from 5:30-6:45 pm.

Hors d’oeuvres and refreshments will be served.

7:30 am Breakfast 7:50 am Opening Remarks/Day 1 Review

Jennifer Liu, MD and Richard M. Steingart, MD

Research Progress8:00 am Applying the Results of the Late Breaking Trials to the Cardiovascular Care

of Patients with Cancer Marielle Scherrer-Crosbie, MD, PhD

Imaging in Cardio-Oncology: Diagnostic Strategies for Early Detection of Cardiotoxicity

8:20 am Multimodality Imaging – Why, Which Test and How Often? Jennifer Liu, MD

8:40 am The Role of Serum Biomarker – When to Use? Bonnie Ky, MD

9:00 am The QT Interval Conundrum in Patients with Cancer – How to and Why Measure QT Interval? Michael Fradley, MD

9:20 am Cardiac Masses Jonathan Weinsaft, MD

9:40 am Panel Discussion/Q&A

Immunotherapy – Emerging Cellular Therapies 10:00 am CAR T-Cell Therapy: Navigating a New Frontier

Miguel Perales, MD10:20 am Understanding the CV Manifestation of CAR T cell Therapy

Ana Barac, MD, PhD10:40 am Q&A10:50 pm Break

Radiation Heart Disease11:05 am Radiation Therapy: Strategies to Minimize Radiation Induced Cardiotoxicity –

Past, Present and Future Oren Cahlon, MD

Saturday, May 16, 2020

11:25 am Cardiovascular Complications of Radiation Richard M. Steingart, MD

11:45 am Practical Management Algorithm of Patients with Radiation Associated Heart Disease Milind Desai, MD

12:05 pm Panel Discussion/Q&A12:20 pm Lunch Break

Cancer Survivorship and Prevention1:00 pm Late Onset Cardiotoxicity in Adult Survivors of Childhood Cancer:

Incidence, Risk Factors and Individual CV Risk Prediction Gregory Armstrong, MD, MSCE

1:20 pm How to Mitigate Cardiotoxicity – Role of Exercise, Statin and Cardioprotective AgentsMichelle Johnson, MD, MPH

1:40 pm Balancing Cancer Success Against Cardiotoxicity: A 3-Act Play ACT I: Oncologist Planning Curative but Potentially Cardiotoxic Treatment for an Aggressive Cancer – Ellin Berman, MD

ACT II: Patient Presses the Cardio-oncology Consult on the Tolerability of the regimen – Richard M. Steingart, MD

ACT III: An Exciting Meeting of the Minds2:10 pm Panel Discussion/Q&A

Cardiovascular Challenges in Cancer Patients2:25 pm Clinical Conundrums (20 min each)

• Management of Acute Coronary Syndrome in Patients with cancer: Balancing Risk of Thrombosis vs. Bleeding – Carol Chen, MD

• Interventional Management of Acute Coronary Syndrome and Chronic CAD – Usman Baber, MD

• AF and Anticoagulation – Does the CHADS Score Apply? – James Ip, MD• Autonomic Dysfunction in Patients with Cancer – Anju Nohria, MD

3:45 pm Panel Discussion/Q&A 4:05 pm Closing Remarks

Jennifer Liu, MD

4:10 pm Adjourn

Computer Based Learning Lab*The aim of the learning lab is to provide participants personalized hands-on experience in GLS performance and analysis. Following an introductory lecture on the clinical application of strain, participants will analyze real cases pre-loaded on their own computer workstation under the supervision of the faculty. A step-by-step how to perform and analyze 2D GLS will be demonstrated. Tips on acquiring optimal 2D images for speckle tracking and how to measure GLS accurately will be discussed with examples of common pitfalls to avoid. Seating is limited to allow each participant sufficient opportunity to interact with faculty.

SCHEDULE

4:15 pm How I Use Strain in My Cardio-oncology Practice(Basic Concepts, Clinical Utility/Application, When to Use, How to Implement)Dinesh Thavendiranathan, MD

4:40 pm Hands-on Session 6:30 pm Adjourn

SCHEDULE Registration Information

Early* General

Physicians (MDs, PhDs and DOs) $425 $525

Residents, Fellows, APPs, Nurses and Other Healthcare Providers $250 $350

Live Simulcast n/a $725

Industry Professionals** n/a $925

Computer Based Learning Lab (optional)*** n/a $175

*Early registration rates expires March 15, 2020. Apply promotion code CS20EARLY at registration.**Industry professionals may attend MSK CME activities for their own education. Marketing, sales, and promotion of products and services is strictly prohibited at MSK CME activities.***$50 discount available to attend both the Cardio-Oncology Symposium (Fri.-Sat.) and theComputer Based Learning Lab (Sat.).

In-person course registration includes continental breakfast, lunch, and refreshment breaks. Please contact cme@mskcc.org at least one week prior to the course if you have any special dietary requests or require any specific accommodations.

• MSK Alumni, MSK Cancer Alliance and Cancer Care Partner Discounts Available. Please contact cme@mskcc.org for more information or a promotion code.

• MSK employee registration is complimentary. However, you must complete course registration in order to attend this course.

Symposium Location Rockefeller Research Laboratories430 East 67th StreetNew York, NYMSK has negotiated special rates and amenities at select hotels in Manhattan. For details visit: mskcc.org/cardio-onc

Memorial Sloan Kettering Cancer Center is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

AMA Credit Designation StatementMemorial Sloan Kettering Cancer Center designates this live activity for a maximum of 15.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

ABIM MOC Recognition StatementSuccessful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 15.75 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

Register online, at mskcc.org/cardio-onc

Registration Fees

Accreditation

*The Cardio-Oncology Symposium (Fri.-Sat.) and the Learning Lab (Sat.) can be registered for separately. Discount available when you register for both.

2020 MSKCARDIO-ONCOLOGY SYMPOSIUMmskcc.org/cardio-onc