DAY 1 AT A GLANCE

Innovating how we innovate

8:00 AM Breakfast

8:30 AM Welcome & Introduction Mark Trusheim (MIT) Gigi Hirsch (MIT)

9:00 AM ABI: A Vision for Sustainable, Patient-Centered Drug Development, Access, & Value

Gigi Hirsch (MIT), moderator Mathieu Boudes (EURORDIS) Hans-Georg Eichler (EMA)John Ferguson (Shire)Laurice Levine (Patient advocate) Ed Pezalla (formerly Aetna)

10:00 AM Special Announcement

10:15 AM Roadmap to the Future: From Platform Trials to Disease Focused Innovation Ecosystems

Janet Woodcock (FDA)

10:45 AM Coffee

11:00 AM Fireside Chat Evolution in Action: The iSPY Story

Laura Esserman (UCSF; ISPY)Mark Trusheim (MIT)

11:45 AM Lunch addressOutside-in Learning: Insights from the Evolution of Industry Platforms in Other Vertical Markets

Michael Cusumano (MIT Sloan)

Catalyzing next generation platform trials1:00 PM Advancing Oncology Platform Trials Mark Trusheim (MIT), moderator

Brian Alexander (DFCI: GBM AGILE) Denis Lacombe (EORTC; SPECTRA) Victoria Manax (PANCAN)

2:00 PM Translational System Innovation: Platforms Beyond Oncology

Susan Schaeffer (BioCentury), moderator Marina Kozak (BARDA) Carole Mitnick (HMS)Richard Strauss (J&J)Luc Truyen (IMI EPAD)

3:00 PM Coffee

3:15 PM Stakeholder Perspectives on Platform Trials John Glasspool (MIT), moderator Naomi Aronson (BCBS)Mathieu Boudes (EURORDIS)Peter Kolchinsky (RA Capital Management) Jane Perlmutter (Gemini Group) Eric Rubin (Merck & Co., Inc.)

4:15 PM Evolution of Platform Trials: Lessons Learned So Far Anna Barker (NBDA)

4:50 PM Wrap-up for Day 1 Mark Trusheim (MIT)

5:00 PM Reception & Poster Session

2017 Next Wave Forum at MIT

DAY 2 AT A GLANCE

Connecting data and evidence across the product lifecycle

7:30 AM Breakfast

8:00 AM Welcome & Introduction Mark Trusheim (MIT) Gigi Hirsch (MIT)

8:15 AM Fireside ChatBridging the Chasm: Connecting Pre- and Post-Market Learning

Hans-Georg Eichler (EMA), moderator Gerald Dal Pan (FDA)Trent Haywood (BCBS)Hilary Malone (Sanofi)

9:00 AM Evidence Planning in Adaptive Biomedical Innovation: Field Observations

Kay Larholt (MIT), moderatorNick Crabb (NICE)Anne-Virginie Eggimann (bluebird bio) Robyn Lim (Health Canada)Newell McElwee (Boerhinger-Ingelheim)

9:45 AM Coffee

10:00 AM Driving Value for Patients from Real World Evidence: Snapshots of Evolving Ecosystems

Eleanor Perfetto (NHC), moderatorDerek Angus (U Pittsburgh) Mark Cziraky (HealthCore) Kourtney Davis (GSK) Sebastian Schneeweiss (HMS)

11:00 AM Can Technology Enable Data Sharing, Integration, and Trust?

Alex “Sandy” Pentland (MIT Media Lab)

Advancing from silo-driven to ecosystem-driven innovation11:30 AM Ecosystem-Enabled Innovation: Insights from the

Neonatal CommunitySusan Schaeffer (BioCentury), moderator Ed Connor (Critical Path Institute) Jonathan Davis (Tufts)William Smoyer (Nationwide Children’s Hospital)

12:15 PM Advancing Adaptive Biomedical Innovation: Designing Disease Ecosystems

Gigi Hirsch (MIT)

12:40 PM Lunch

2:00 PM Innovation in Fragmented Health Ecosystems William Rouse (Stevens Institute)

2:30 PM Evolving the Global Ecosystem: The Adaptive Biomedical Innovation Game

Mark Trusheim (MIT)Eric Klopfer (MIT SA+P/Education)

3:15 PM Coffee

3:30 PM The Political Context for Biomedical & Healthcare Innovation

Jonathan Gruber (MIT Sloan)

4:00 PM Driving Continuous Improvement Across the System Don Berwick (Institute for Healthcare Improvement) Pre-recorded interview

4:15 PM Action Plan and Closing Gigi Hirsch (MIT)Mark Trusheim (MIT)

2017 Next Wave Forum at MIT