HompesMethodPrac00onerTrainingLevelII

©HealthforthePeopleLtd–notforreusewithoutexpressedpermissionHompesMethodisatradingnameofHealthForThePeopleL<|RegisteredinEngland&Wales|Company#6955670|VAT#997294742

Lesson Forty Three – Sex Hormones

MainSexHormones

•  Severalhormonesplayprimaryrolesinthemenstrualcycle

•  Whilethey’reknownassex,orreproduc:vehormones,theyexertmanymoreinfluencesonmetabolism–energy,mood,cardiovascular,etc.–  Ifonlydoctorsacknowledgedandhonouredthis!

MainSexHormones

•  Pituitarygonadotropins:–  Follicles:mula:nghormone–  Luteinisinghormone

•  Ovarian:–  Estrogens(1,2,and3)–  Progesterone–  Testosterone

•  Notethatthesehormonescanbemadeoutsidetheovaries•  Thebrain,adrenalsandfatcellscanproducethesehormones•  Theyareallsteroidhormones(derivedfromcholesterol)

FollicleS0mula0ngHormone

•  FSH:– Producedinanteriorpituitary•  Inwomen

–  S:mulatesgrowthofovarianfolliclesbeforethereleaseoftheeggfromthefollicleatovula:on

–  S:mulatesoestrogenproduc:oninovaries» MassivelyimportanthormoneinPCOS

•  Inmen–  ActsonSertolicellsofthetestestos:mulatespermproduc:on

LuteinizingHormone

•  LH:– Producedinanteriorpituitary•  Inwomen

–  Acuteriseinmid-cycletriggersovula:onanddevelopmentofcorpusluteum

–  Triggersoestrogenproduc:oninovaries•  Inmen

–  S:mulatesproduc:onoftestosteroneinLeydigcells

FSHandLHSummary(Wikipedia)

Puberty

•  Hypothalamusbeginssecre:ngGnRH•  TriggersFSHandLH•  Age11ingirls,age12inboys

–  Influencedbygene:cs(small),inflamma:on,otherhormones(e.g.insulin,cor:sol,lep:n),autoimmuneissues(possibly),etc.

Estrogens(E1,E2,E3)

•  Produc:on–  Ovaries–  Folliclearoundtheovum(egg)–  Adrenalglands–  Fatcells

•  Exogenous–  Birthcontrol–  HRT(menopause)–  Environmentalestrogensandestrogenmimickers

Estrogens(E1,E2,E3)

•  E1–Estrone– MadeaXermenopauseinfatcellsfromandrostenedione,andalsoinovaries

–  Correlateswithbeingoverweight•  E2–Estradiol– Mostac:veandpotent– MostcellshaveE2receptors

•  E3–Estriol– Weakestandleastac:ve–  Predominantlymadebyplacenta(someinliver)–  Affectsvaginalwalls–  Receptorsonhair,nails,skin,mucosalmembranes

Estrogen–generaleffects

•  Reproduc:ve:– Maintainsandlubricatesvagina,vulvaandcervix–  Helpstomaintainvaginalmicrobiome–  Causeseggtomatureinsidefollicle–  Supportsgrowthoffollicle– Makesuterinelininggrowtoprepareforpregnancy–  Helpsbreast:ssuesgrowinprepara:onformakingmilk–  Promotesfoetalgrowth–  S:mulatesbodyfataccumula:ontohelpthefoetusgrow

Estrogen–generaleffects

•  Non-Reproduc:ve:–  Preventsbonedestruc:onbyosteoclasts–  Protectsagainsthighbloodpressure–  S:mulateslipoproteinlipase–  Reducesinsulin–  Relaxesbloodvesselsinheart–  Feelingsoffemininity–  Improveslibido/sexdrive–  Supportsmemory–  Improvesskintone–  Mood(protectsagainstdepression)–  Supportssleep

Progesterone

•  Produc:on:–  CorpusluteumaXerovula:on•  Onlywhileawomanisovula:ng

–  Producedinhighamountsbyplacentaoncepregnancyoccurs

–  Adrenalglands•  Viapregnenolone

–  Testes–  Brain•  Veryhighconcentra:onsfoundhere

Progesterone–generaleffects

•  Reproduc:ve:–  Pro-gesta*onalhormone(pro-gest-erone)–  Improvessexdrive(includingmen–Icana\esttothis!)–  Preparesendometriumforimplanta:onoffer:lisedovum–  Cri:caltosurvivalofovumoncefer:lized–  Ensuresfoetalsurvival–  Preventsovergrowthofendometriumandbreast:ssue–  Preventsfibrocys:cbreasts–  Increasesestrogenreceptorsensi:vity

Progesterone–generaleffects

•  Non-reproduc:ve:–  Actsagainstestrogensasaprotec:vemeasureandtomaintain

op:malbalance–  Pro-metabolic(supportsthyroid,burnsfat)–  Naturalan:-anxiety/calmingeffectandan:depressant–  Improvessleep–  Helpstomaintainop:malbloodsugarandinsulin–  Helpstobuildbone–  Protectsthebrainandpreventsepilep:cseizures–  Essen:alforthymusandimmunefunc:on–  Neededfordetoxifica:on–  Improvescardiovascularfunc:onandreducesclo_ng–  Relievesarthri:s–  Significantlyeffectsdiges:oninsomewomen

Testosterone

•  Produc:on(women)–  Ovaries–  Adrenals

•  Viasteroidhormonepathways

–  Corpusluteum

•  Men–  Testes–  Adrenals

•  Viasteroidhormonepathways

Testosterone–generaleffects

•  Reproduc:ve:–  Improvessexdrive/libidoinmenandwomen–  Increasessexualfantasies–  Enlargementofpenis–  Enlargementofclitoris–  Clitoralsensi:vity–  Orgasmstrength

Testosterone–generaleffects

•  Non-reproduc:ve:–  Promotesmusclestrength–  Libidomeans“driveforlife”–  Improvedsenseofconfidenceandwell-being–  Improvesbonedensity–  Feelingsofsecurity–  Boundaryse_ng–  Bodyhair(subjecttoindividualtaste!)

WhatAffectsSexHormoneFunc0on?

•  Hormoneproduc:on•  Transportandavailability•  Receptoravailabilityandbinding•  Breakdownandexcre:on

– Manythingscaninterfereandcompromisethese–  It’snotjustaboutthehormonelevelinalabtest

WhatAffectsSexHormoneFunc0on?

Hormoneproduc:on

Transportand

availability

Receptoravailability

andbinding

Breakdownand

excre:on

HormoneProduc0on

•  HormoneProduc:on:– Rawmaterials•  Cholesterolisneededforsteroids

–  Diet,diges:onandabsorp:on•  Nutri:onal/enzymeco-factors

–  T3,vitaminA,vitaminB5,etc.

– HPGaxisfunc:on•  Hypothalamus,pituitary,gonads

–  Toxins,infec:ons,inflamma:on– Mold(CIRS)–  Stressinallforms

Transport&Availability

•  Transport&availability:–  Only1-2%ofho–  Transcor:n/Cor:costeroid-bindingglobulin

•  Bindsprogesteroneandcor:sol–  SERPINA6genepolymorphismsarebeinginves:gated

–  Sexhormonebindingglobulin(SHBG)•  Glycoproteinproducedinliver,brain,uterus,testesandplacenta•  Bindsestrogensandandrogens,renderingthem“inac:ve”•  Insulin,thyroid,prolac:n,growthhormoneinfluencelevels•  Alsotransportedonalbumintoalesserextent

–  SHBGGenepolymorphismsarebeinginves:gated

Receptoravailabilityandsensi0vity

•  Possibleproblems:–  Gene:c

•  Estrogeninsensi:vitysyndrome(EIS)–rela:velyrare•  Androgeninsensi:vitysyndrome(AIS)–rela:velycommon•  Completeandrogeninsensi:vitysyndrome(sterility)

–  Blockedsexhormonereceptors•  Highinsulin•  Thepill,HRT,etc.

–  Otherxenoestrogens–plas:cs,pes:cides,etc.?•  Medica:ons(usuallyforbreastcancer)

–  Selec:veestrogenreceptormodulators–SERM

Hormonebreakdownandexcre0on

•  Factorsaffec:nghormoneclearance:–  Ongoingexposure

•  Notjusttohormones,butalsostressorsandtoxins(e.g.mold)

–  Gene:cpolymorphismissues•  MTHFR,COMT,SULT,NAT,CYP,etc.

–  Enzyme/nutri:onalcofactors•  Iron,Bvitamins,glutathione,etc.

– Microbiomeandbeta-glucuronidase•  Elevatedb-glucuronidaseenablesestrogenreabsorp:on

Summary

•  ThepituitaryhormonesareFSHandLH•  Themainsexhormonesareprogesterone,estrogensx3andprogesterone

•  Theyrunthemenstrualcycle•  Theyhavefar-reachingrolesbeyondreproduc:on•  It’snotjustabouthormoneproduc:onandlevels–it’salsoabouttransport,receptorsandbreakdown

Thankyou!

•  Thanksamillfordevouring.Nextup,we’lllookatwhatcangowrongwiththemenstrualcycleanditsassociatedhormones,andbeginlookingintoWHYitcanallgowrong.

h\p://journal.fron:ersin.org/ar:cle/10.3389/fendo.

2014.00192/full

h\p://www.medscape.com/viewar:cle/523196_3

h\ps://en.wikipedia.org/wiki/

Estradiol

h\ps://en.wikipedia.org/wiki/

Estradiol

h\ps://www.researchgate.net/figure/7360494_fig1_The-estradiol-metabolic-pathway-Estradiol-is-synthesized-from-cholesterol-in-a-series-of

h\p://catsfork.com/Health-Metabolism/

Hormones-Female.html

h\ps://clinicalgate.com/adrenal-exhaus:on/

TheSexHormonePlayers(func0ons)

TheSexHormonePlayers

•  Thetableisnotexhaus:ve,butitgoessomewaytoshowingyouhowhormoneimbalancescanhaveaprofoundsystemiceffectthatgoeswaybeyondjustthefunc:onsofsexandprocrea:on.

TheSexHormonePlayers(deficiencySx)

•  Ialsocreatedali\lesummarytableofsymptomsthatmaydevelopduetodeficienciesoftheaforemen:onedhormones.

•  Wecommonlyobservehormoneexcessesaswell…•  …orvariouscombina:ons.–  Cor:solexcesswiththyroiddeficiency–  Cor:solexcesswithprogesteronedeficiency–  Oestrogenexcesswithprogesteronedeficiency–  Etc…

TheSexHormonePlayers

MyTopResources

•  I’vereaddozensofbooksabout“hormonebalance”inmy:meands:llhavefewontheshelfthathaveasyetgoneunopened.

•  Onthefollowingpagesyou’llfindmytopthreeorfourpicks.

•  I’veprovidedplentyofvideosandar:clesinyourresourcessec:on,aswell.

MyTopResources

•  NaturalHormoneBalanceMadeSimple–JohnLee,M.D.–  Oneofthepioneersinthefieldofprogesteronetherapy,thisbooksummarizesDr.Lee’sworknicely.

–  Dr.KalishlearnedagreatdealfromDr.Lee.

MyTopResources

•  TheNaturalSuperwomanbyUzziReiss,OBGYN.–  Quitesimplyabrilliantbookwhenitcomestohormoneeduca:on;Dr.Reisshasbeenhelpingwomenbalancetheirhormonesformorethanthirtyyears.

MyTopResources

•  StayYoungandSexywithBioidenYcalHormoneReplacement–JonathanWright,M.D.–  Dr.Wrightwastheguywhoeffec:velybroughtbioiden:calsintoprac:ce.Thisbookcarriesawealthofscien:ficevidencesuppor:nghormonetherapy.

MyTopResources

•  DiscoverYourMenopauseTypebyJosephCollins,N.D.–  Thisisasuperbbookthatbreaksmenopausesymptomsdownintodifferenttypesandtreatments.

MyTopResources

•  TheBi<erPill–Dr.EllenGrant,M.D.–  Afascina:ngexplora:onofhowthepillwasdevelopedintheUK,alongwiththedisturbingside-effectsthatcame–ands:llcome–alongwithit.

MyTopResources

•  Menopause–ASpiritualRenaissance–HeleneB.Leone_,M.D.–  LovelybookbyaladyI’vehadthefortunetointerview.

MyTopResources

•  BHRTWorldSummit–Various;hostedbyJoelYaffa,M.D.:–  Excellentsummitwithopinionsfromvariousleadingexperts.Givesagoodspreadofopinion.

MyTopResources

•  Therearesomeothersuperbresources,andI’llmen:onthemaswegoalongaswellaslis:ngthemonaresourcesheetforyou.

ThankYou!

•  Thanksamillion!Inthenextlessonwe’lllookatthespecifichormonesinvolvedinthemenstrualcyclesowecanthendiveintowhatcangowrong.