2010 Southeast RegionTechnology TransferDirector’s Meeting 7.30.2010

Scott Sewell

Vice President Technology Acquisition & Development

Early Beginnings

Bloomington, Indiana

Overview• Cook established in 1963 – offers three products• Today, 15,000+ products, 9,000+ employees worldwide,

16 medical entities, manufacturing on three continents, nine (9) strategic business units (SBUs), 2 shared service centers, distribution into more than 135 countries across more than 35 regulatory regions

• Global representation interacting with 42 medical specialties focused on development of minimally-invasive and converging medical technologies (Devices, Biotechnology, Biopharma and Cell Therapy)

Business Unit Focus• Aortic Intervention

– Interventional technologies providing endovascular solutions for cardiovascular disease affecting aorta and its branch vessels

- Vascular Surgery- Thoracic Surgery

• Lead Management– A stand alone business emerging from Peripheral and Aortic Intervention - Electrophysiology- Cardiology

• Critical Care– Antibiotic-Impregnated central venous catheters, difficult airway management devices. - Anesthesia- Critical Care Medicine- Emergency Medicine- Pulmonary Medicine- Pediatrics/Neonatology

• Endoscopy– Interventional technologies that enhance efficient diagnoses and provide effective treatment

for patients with biliary, pancreatic and esophageal/colonic/gastric diseases- Gastroenterology

Business Unit Focus• Peripheral Intervention

Vascular and non vascular access and treatment technologies supporting medical outcomes-based interventional procedures in radiology, neuroradiology and vascular surgery

- Interventional Radiology- Interventional Cardiology- Vascular Surgery

• Surgery Biodesigned regenerative scaffold technology used to signal the body to remodel weakened or damaged soft tissue.

- General Surgery- Colo-Rectal Surgery- Plastic/Reconstructive Surgery- Neurosurgery- Reconstructive Microsurgery

• Urology Interventional and biodesigned technologies focusing on adult and pediatric urology with an emphasis on stone management and pelvic health

- Urology

• Women’s Health Technologies to support reproduction, high risk obstetric and gynecologic procedures and incontinence

- Obstetrics- Gynecology- Embryology

Core Technologies

• BIOPHARMA - Cutting edge technology to enhance the development and

delivery of vaccines and therapies. These are mammalian cell “factories” to produce the antibodies that deliever the targeted medicine.

• Biotech – Biodesigned regenerative scaffold used to signal the body to remodel weakend or damaged soft tissue while providing long term strength and support.

• Gene Therapy – Antisense, a gene –therapy compound that targets key genes responsible for cell migration and adhesion, collagen formation, secretion of extracellular matrix with potential use in drug eluting stents.

• Cell Therapy – Extracting and deriving muscle-derived cells, this technology is used to treat various conditions where tissues have grown weak or lost their initial function.

Unique Technologies

Biotechnology

Dural Graft Anal Fistula Plug Staple Line Reinforcement

Aortic Aneurysm Repair

Drug Eluting Stents

Antibiotic Impregnated Catheters

Spectrum Technology

Winston-Salem, North Carolina

In 1983, Don Wilson and Bill Cook saw the need for minimally invasive devices in the growing field of gastroenterology.

Don WilsonBill Cook

Over 45 years of experience developing devices

Our Process in a nutshell:

1. Gather ideas from a varietyof sources

2. Establish clinical development

partners (clinicians with interest

and expertise in the selected

device area)

3. Develop a detailed understanding

of the problem and

proposed solution(s)

4. Evaluate prototypes

5. FDA Filing

6. Limited release/evaluation

7. Full release

At the Forefront of Research and Development

We have a successful history of commercializing devices and have the infrastructure and knowledge to support research projects such as NOTES to become a reality

Cook is dedicated to

bold leadershipbold leadership in pioneering

innovative medical solutionsinnovative medical solutions

to enhance patient care worldwideworldwide.

– mission statement