2009-2010 Neurosciences Student Handbook Updated 1-19-10

8/3/2019 2009-2010 Neurosciences Student Handbook Updated 1-19-10

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20092010NEUROSCIENCESHANDBOOK

TableofContentsPage

DepartmentalDirectory 24

NeurosciencesatCWRU 58

ProgramRequirements 810

Courses 1113

Examinations 1415

ChangeofStateNotification 15

ResearchIntegrity 15

GuidelinesforThesisResearch 1518

MasterofNeuroscienceDegree 1819

PostdoctoralFellows 19

NeurosciencesFacilities 1922

Other

Facilities/Services

22

UsefulWebsites 23

Currentstudents 24

AlumnioftheNeurosciencesProgram 2526

*pleasesendanycorrectionsforthehandbooktoKatieWervey([email protected])*


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PRIMARYFACULTY

HeatherBroihier(htb)

SchoolofMedicineE714

OfficePhone#3684326

LabPhone#3680657

RebeccaJames(rej10)

NanLiu(nxl23)

Crystal(Kozora)Miller(cxk81)

InnaNechipurenko(ivn2)

YiLanWeng(yxw71)

GemmaCasadesus(gxc40)

SchoolofMedicineE729&728

OfficePhone#3688503

LabPhone#3682018

JaewonChang(jxc176)DeniseHatala(dah13)

HyunjinKim(hxk199)

JenniferReeves(jer112)

EvanDeneris(esd)

Schoolof

Medicine

E648

OfficePhone#3688725

LabPhone#3688724

StephanieFox(srf12)

ChenLiu(cxl115)

KatherineLobur(kjl16)

HiroshiMaeno(hxm57)

StevenWyler(scw58)

DavidFriel (ddf2)


OfficePhone #3684930

LabPhone

#368

1915

RobertoGalan(rfg8)


OfficePhone#3680811

GermanCardenasLeroy(gxc128)

PavelPuzerey(pxp190)

KarlSteinke(gks5)

YenanZhu(yxz107)

AlisonHall(axh8)


OfficePhone#3686711

LabPhone

#368

6710

SarahO'Keeffe(seo5)x5655

JamieRhodes(jlr124)

StefanHerlitze(sxh106)


OfficePhone#3681804

DavinaGutierrez(dvg1)

TakashiMaejima(txm130)

EugeneOh(exo16)

DavidKatz(dmk4)


OfficePhone#3686116

LabPhone#3686179

IanAdams(ita)

MichaelOgier(moo3)

DanielleSchmid(das197)

TaliaSukol([email protected])

QifangWang(qxw12) (E717)

DianaKunze

([email protected])

MetroHealthMedicalCenter

2500MetroHealth

ClevelandOhio44109

OfficePhone#2167788967

LynnT.Landmesser(ltl)CHAIR

(E643A)E627Lab


OfficePhone#3683996

LabPhone#3684896

KseniaKastanenka(kvk3)

KatherineLobur(kjl16)

YukaMaenoHikichi(yxm29)

ShengWang(sxw203)

GaryLandreth(gel2)


OfficePhone#3686101

LabPhone#3683435

BrentCameron(bdc22)PaigeCramer(pec9)

ColleenKarlo(jck2)E640

DonnaKirsch(djk15)

ChungYing(Daniel)Lee(cxl142)

ShwetaMandrekar(sdm19)

LaurenOgrich(lmo11)

DanielaPopescu(dcp58)

JoannaPucilowska(jxp190)

ErinReed(egr3)

JulieSavage(jcs30)

WendyMacklin

([email protected] )

UofColoradoDenverHealth

SciencesCenter

Aurora,CO80045


YiDong(yxd26)

RobertMiller(rhm3)


OfficePhone#3686269

LabPhone #3686170

LianhuaBai(lxb65)

AndrewCaprariello(avc9)DPB

AnneDeChant(akd6)x5473

SharylFyffeMaricich(slf53)

SaraVandommelen(slv15)x6269

YanYang(yxy33)

AnitaZaremba(axz2)

JerrySilver(jsx10)


OfficePhone#3682150

LabPhone#3685574(E658)

WarrenAlilain(wja4)

SarahBusch(sab37)

MarcDePaul(mxd359)

TeresaEvans(teresa.evans)

HongmeiHu(hxh67)

BradleyLang(btl21)

Angela(Nord)Filous(arn29)

BenStrowbridge(bxs48)


OfficePhone#3686974

LabPhone#3681041

YuanGao(yxg30)

RobertHyde(rah38)

LorenSchmidt(ljs102)

RossAnderson(rwa4)DPB

IsaacYoungstrom(iay4)

BruceTrapp([email protected])

ClevelandClinicFoundation

BuildingNC30

9500EuclidAvenue

ClevelandOhio44195


LabPhone#2164448712

MariaSmith(mcs59)

ElizabethYoung(eay9)

RichardZigmond(rez)


OfficePhone#3684614

LabPhone#3684615

AliciaLisowitz(aal39)
mailto:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]


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SECONDARYFACULTY

KumarAlagramam(kna3)

Otolaryngology

Lakeside7123

OfficePhone#2168447261.

Chunyang(Brian)Bai(cbb9)

Genetics

BRB621

OfficePhone#3680305

SusannBradyKalnay(smb4)

Molecular&Microbiology

SchoolofMedicineW214b

OfficePhone#3680330

MatthiasBuck(mxb150)

Physiology&Biophysics


Office

Phone

#

368

8651

HillelChiel(hjc)

Biology301

OfficePhone#3683846

LabPhone#3683574

ThomasDick(ted3)

Pulmonary/CriticalCare

BRB319

OfficePhone#3688637

RishiDhingra(rxd50)

DominiqueDurand

(dxd6)

BiomedicalEngineering

Wickenden112

OfficePhone#3683974

PaulErnsberger(pre)

Nutrition

DentalSchool201

OfficePhone#3684738

JosephLaManna(jcl4)

Neurology

BRB

525

OfficePhone#3681112

BruceLamb(btl)(Adjunct)

Genetics

BRB7thFloor

OfficePhone#3682979

SunghoLee(sxl265)

RichardJohnLeigh(rjl4)

Neurology

Lakeside3080

OfficePhonel#2168443190

StephenMaricich(smm18)

Pediatrics


OfficePhone#3682194

LabPhone#3680066

SaedAbokor(sxa359)

BrianMcDermott,Jr.(bmm30)

Otolaryngology

WearnBldg.,Room452


MaureenMcEnery(mwm4)

General

Medical

Sciences

SchoolofMedicineWG11

OfficePhone#3683377

IrvineMcQuarrie(igm)

NeurologicalSurgery

VAMedicalCenter

OfficePhone#7913800

ElizabethPehek(eap6)

Psychiatry

VAMedicalCenterBrecksville


RobertPetersen(rbp)

Pathology

InstituteofPathology204

OfficePhone#3686709

RoyRitzmann(rer3)

Biology

BiologyBuilding207

OfficePhone#3683554

ShenandoahRobinson(sxr47)

NeurologicalSurgeryOfficePhone#2168444922

Lab:SOME720

QingLi(qxl5)x4865

StephanieEaton(see14)

RobertRuff(rlr)

Neurology

LakesideHospital3080


ShastaSabo(sls79)

Pharmacology

SchoolofMedicineW305C

OfficePhone#3685683

RuthSiegel(res7)

Pharmacology

SchoolofMedicineW319

OfficeTelephone#3685554

LabPhone#3686024

CoreySmith(cbs16)

Physiology&Biophysics


OfficePhone#3683487

SophiaSundararajan(srt2)

Neurology

Lakeside3080OfficePhone#2168448421

ManSunSy(mxs92)

Pathology

BRB9thFloor

OfficePhone#3681268

ErikvanLunteren(exv4)

Pulmonary/CriticalCare

VAMedicalCenter

OfficePhone#7913800

NicoleWard

(nlw4)

Dermatology

BRB526

OfficePhone#3681111

ChristopherWilson(cgw5)

Pediatrics

RB&C



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ADMINISTRATIVEOFFICESchoolofMedicineE653

NarleneBrown(nrb)

AdministrativeManager

OfficePhone#3686253

PamMcGregor

(pam7)

GrantsManagementSpecialist

OfficePhone#3686251

KatieWervey(kar18)

GraduateStudentCoordinator/AssistanttoChair

OfficePhone#3686252

CENTERFORTRANSLATIONALNEUROSCIENCES

http://www.case.edu/med/CTN/index.html


RobertMiller,Director,3685473,(rhm3)

AnneDeChant,AdministratorfortheCenter,3685473,(akd6)

CWRURODENTBEHAVIORCOREhttp://neurosciences.case.edu/crbc/home


GemmaCasadesus,CoreDirector,3688503,(gxc40)

JenniferReeves,CoreTechnician([email protected])

NEUROSCIENCESIMAGINGCENTERhttp://neurosciences.case.edu/imaging/index


BenStrowbridge,Director,3686974,(bxs48)

MaryannePendergast,TrainingandFacilityManager,3682575orcell:2162248649,(mxp19)

LynnLandmesser,GarvinProfessorandChair,Neurosciences,3683996,(ltl)

ITSpecialistHarryMenegay(hxm8)
mailto:[email protected]:[email protected]:[email protected]://www.case.edu/med/CTN/index.htmlhttp://www.case.edu/med/CTN/index.htmlmailto:[email protected]:[email protected]://neurosciences.case.edu/crbc/homemailto:[email protected]:[email protected]://neurosciences.case.edu/imaging/indexhttp://neurosciences.case.edu/imaging/indexmailto:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]:[email protected]://neurosciences.case.edu/imaging/indexmailto:[email protected]:[email protected]://neurosciences.case.edu/crbc/homemailto:[email protected]:[email protected]://www.case.edu/med/CTN/index.htmlmailto:[email protected]:[email protected]:[email protected]


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NeurosciencesatCWRU

TheDepartmentofNeurosciences,locatedintheEastWingoftheCWRUMedicalSchool,offers

graduateeducationandpostdoctoraltraininginawiderangeofdisciplinesinmodern

neuroscience.Trainingisprovidedthroughacombinationofresearch,courseworkand

seminars.Thedepartmenthostsweeklyseminars,journalclubs,asocialhour,andinvites

talentedundergraduatestoparticipateinresearchoverthesummer.Thesisresearch

opportunitiesareavailablewithmorethan20facultymembersworkinginareassuchas

developmentofmotorandsensorysystems,regeneration,pathfindingbyaxons,

neurogenetics,regulationofneurotransmitterexpression,neuronglialinteractions,synaptic

physiologyandplasticity,ionchannelbiophysicsandinformationprocessing.Inthelastdecade,

ourdepartmenthasconsistentlyrankedinthetopfifteenpercentofNeuroscienceprograms

nationwideinNIHfunding(2005Caseranked14thinNIHfunding).Onefeatureofthe

Departmentthatmakesitparticularlyattractiveisthehighlyinteractiveatmosphere,

characterizedbyextensivecollaborationsamonglaboratoriesandwithotherinvestigators.

NeurosciencesDepartmentOfficeSOME653

Phone2163686253FAX2163684650

Website:http://neurosciences.case.edu/

TrainingPhilosophy

GraduateeducationinNeurosciencesatCWRUaddressesmanyaspectsofthescience

profession,andinvolvesbothformalcourseworkandinformalinteractions.Bothfacultyand

studentsprosperwhenstudentsareconsideredaspromisingjuniorcolleagues,deserving

dedicatedguidancefromthescientificcommunity.

"TheDoctorofPhilosophydegreeisthehighestacademicdegreegrantedbyNorthAmerican

universities.

It

is

a

research

degree

and

is

to

be

distinguished

from

other

doctorates

such

as

the

M.D.,J.D.orEd.D.degrees,whicharedesignedforprofessionaltrainingorwhichfocuson

appliedratherthanbasicresearch....TheDoctorofPhilosophydegreeisdesignedtopreparea

studenttobecomeascholar,thatis,todiscover,integrateandapplyknowledge,aswellas

communicateanddisseminateit...Theprogramemphasizesthedevelopmentofthestudent's

capacitytomakesignificantoriginalcontributiontoknowledgeinacontextoffreedomof

inquiryandexpression."

CouncilofGraduateStudies

Neuroscientiststodayrequiremanyskillstosucceedinacompetitiveenvironment.Our

Neurosciencestudentscanexpecttrainingin1)scientificexcellence,withcloseinteractions

withfacultyadvisorsleadingtoanunderstandingofproblemsolving,criticalanalysisofdata

andmoderntechnicalapproaches,2)communicationskills,includingpracticeandadviceinthe

analysisofcontemporaryliterature,grantsmanship,andoralpresentationsand3)Ethics,to

makecomplexdecisionsonauthorship,datahandling,andintellectualproperty.


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StudentActivities.Graduatestudentsareexpectedtoinitiateandparticipateinavarietyof

activitieshavingtodowithprofessionalgrowth:

DepartmentalRepresentativestoCaseprograms.AlldepartmentscontributetotheCWRU

GraduateStudentSenate(http://gss.case.edu/)thatdiscussesissuesthataffectgraduate

students.TeresaEvansandAngela(Nord)FilousarecurrentNeurosciencerepresentativesto

GSS.

JournalClubsandSeminars.Journalclubsandseminarsofferanopportunitytolearnabout

broadareasofNeuroscience,andformanimportantpartofgraduatetraining.Allstudents,

postdoctoralfellowsandfacultyareexpectedtoattendboththeJournalClubMondaysatnoon

(SOME646)andtheNeurosciencesSeminarThursdaysatnoon(BRB105unlessotherwise

specified).Studentsarestronglyencouragedtoactivelyparticipatebyaskingquestionsat

seminarsandjournalclubs.Dr.RichardZigmond(rez)organizestheseminarscheduleandDr.

GaryLandreth(gel2)organizesthejournalclubcalendar.

Togainoralpresentationskills,studentsandpostdoctoralfellowsshouldmakeformal

presentationstotheNeurosciencecommunityatleastonceayear,afterpractice

with

their

facultyadvisors.Studentsinthefirst3yearsmayelecttopresentacurrentresearcharticle

fromaprominentjournal.Facultyofferconstructivecriticismtothestudentdirectlyfollowing

thepresentation.Postdoctoralfellowsandexperiencedstudentsusuallypresenttheirresearch

workwithrelevantbackgroundandsignificance,butmayopttodoajournalclub.

Meetingoutsidespeakersforlunch.Studentsandpostdoctoralfellowsareencouragedto

meetwithvisitingspeakersatlunchfollowingthenoonseminar.Thisisagoodopportunityto

practicetalkingaboutscienceinaconcise,interestingway.Further,itoffersameanstogetto

knowthespeaker,his/herinstitutionandtodiscussscientificstrategiesorcollaborations.To

meet

with

a

speaker,

contact

the

student

lunch

coordinators,

Ross

Anderson

(rwa4)

or

Loren

Schmidt(ljs102)(for200910academicyear)toreserveafreelunch.Astudentorpostdoc

shouldexpecttomeetwithatleast4speakersayear.

Neurosciencetextbookandcomputer.StudentscommittedtotheNeuroscienceProgramfor

theirthesisworkareprovidedacopyofKandel,SchwartzandJessell,PrinciplesofNeural

Science.Similarly,oncestudentscommittoalaboratory,alaptopcomputerwillbeprovidedfor

useincompletingstudies.Ifastudentsubsequentlychangesprograms,thetextbookand

laptopmustbereturnedforfutureuse.

Studentsponsoreddepartmentalspeaker.Onespeakerayearisselectedandsponsoredby

thegraduatestudentsintheDepartment.Visitingfacultyarehonoredbythisdistinctionand

areveryaccessibletostudentsduringthevisit.Facultyinputaboutcandidatesisencouragedto

ensurethat"studentfriendly"speakersareselected.Studentscreatethescheduleforthe

speaker,arrangelunchwithstudentsandpostdocs,introducethespeakerattheseminar,

createadepartmentwidedinnerwiththespeaker,areresponsiblefortransittoandfrom

theairportandhotelreservations.

GraduateStudentSymposium.Thegraduatestudentsinthebiomedicalsciencesorganizea

symposiumonceayearthatincludesstudentpostersandakeynotespeakerinvitedby


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students.ThefacultyadvisorforthisprogramisDavidMacDonald.Manystudentissuesare

representedbytheNationalAssociationofGraduateandProfessionalStudents

(http://www.nagps.org/).

Attendingnationalmeetings.Studentsareencouragedtopresenttheirworkatnational

meetingsonceayear.ThemostappropriatemeetingsmaybetheSocietyforNeurosciences

AnnualMeetingoraGordonConference.Studentsshouldcompeteforindividualtravelgrants

aswellasfundsfromtraininggrants.MSTPstudentsoftencangetpartialreimbursementfor

meetingcostsiftheypresentaposterortalkatascientificmeeting.

Recruitmentofprospectivegraduatestudents.Oftenthemostcandidviewofourprogram

comesfromcurrentstudents,andthatviewpointisveryvaluabletoprospectivestudents.

StudentshostprospectivestudentsfromotherinstitutionsduringtheSpringrecruitment

weekend,andserveasambassadorsoftheinstitutionandprogram.

IndividualPredoctoralSupport.Onceaccepted,graduatestudentswhotrainwith

NeurosciencesDepartmentP.I.sareguaranteedstipendsupportbytheDepartmentforfive

yearsiftheyremainingoodstanding.Supportforadditionalyearsmaybeprovidedbut

requiresanindividualpetition.StudentswhochoosetotrainwithP.I.soutsidetheDepartment

ofNeurosciencesshouldnotethattuitionandstipendsupportwillbetheresponsibilityofthe

trainingP.I.andhis/herdepartment.AletterofsupportisrequiredfromthetrainingP.I.and

chairofdepartmentstatingthattuitionandstipendwillbeguaranteedforatleastfiveyears.

ThislettermustbereceivedbytheDepartmentofNeurosciencesbeforeastudentbegins

trainingwiththechosenP.I.StipendsupportmayderivefromNIHtraininggrants,NIH

individualresearchgrants,federalandprivateresearchgrantsanduniversityresources.Tuition

isgenerallypaidbythetrainingfacultymembersprimarydepartment.Itishighly

advantageousforstudentstosuccessfullycompeteforindividualgrantsupportfrom

extramuralsources,andthedepartmentstronglyencouragessuchapplications.Neuroscience

students

have

been

successful

in

obtaining

National

Research

Scholar

Fellowships

from

the

NIH

(pleaseseehttp://grants.nih.gov/grants/guide/noticefiles/NOTOD07052.html)andthe

AmericanHeartAssociation(pleasesee

http://www.americanheart.org/presenter.jhtml?identifier=2457#Predoc).Notethatseveral

agenciesrequireapplicationsearlyingraduatetraining.TheOfficeofGraduateEducation

maintainsalistofgraduatefundingopportunities

http://casemed.case.edu/gradprog/grantsources.html.

GraduateStipendandBenefits

FulltimeregisteredNeurosciencestudentsareeligiblefortuitionandstipendsupport(see

above).Thestipendleveliscurrently$25,000fortwelvemonthsforthe20092010academic

schoolyear. StipendsarefundedbyNIHtraininggrants,NIHindividualresearchgrants,federal

andprivateresearchgrantsanduniversityresources.InAugust,2000,theDeanofGraduate

Studiesinformedstudentsthat"incometaxwillbewithheldonlyonthestipendportionof

compensation(stipendplustuition)chargedtofederalresearchgrants."Notethatstudents

mayalsoberequiredtopaylocaltaxesiftheyliveoutsidethecityofCleveland.Informationcan

beobtainedfromeachmunicipality.TheDepartmentpaysforstudenthealthservices.Acopy

oftheCWRUMedicalPlanforStudentscanbeobtainedattheUniversityHealthServices,2145

AdelbertRoad.

UniversityHealthService2163682450


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8

Appointments:

GeneralClinic2163684539

WomensClinic2163682453

MentalHealth2163682510

UniversityCounselingService2163682510

NeurosciencesProgramRequirements

Itistheresponsibilityofthestudenttobecomefamiliarwiththegeneralrulesandregulations

oftheUniversity(availableintheGeneralBulletin,http://www.case.edu/bulletin/)aswellas

thespecificruleswhichapplyforthecourseofstudyinNeuroscience(thisdocument).

TheNeurosciencesGraduateProgramAdvisor(GPA)is

Dr.GaryLandreth

E649(SOM)

3686101;[email protected]

TheGraduateProgramAdvisoroverseesgraduatetrainingintheNeurosciencesProgram.The

GPAisavailabletodiscussprogressandprovideadviceoncourseselection. TheGPAalso

coordinatesstudentactivitiesandservesasastudentadvocateshoulddifficultiesarise.

AllstudentsmustsubmitaPlannedProgramofStudy(PPOS)bytheendoftheir2ndsemester

throughtheStudentInformationSystem(SIS)byusingthe"CoursePlanner"and"MyProgram"

tabs(thebasiccurriculumwillbegiventonewstudentsattheirinitialmeetingwiththeGPA

whentheyfirstarrivetothedepartment. Credithoursshouldneverexceed9hoursinany

semestersinceaidisnotavailableforanythingabove9credithours). Ifastudentfailsto

submitaPPOSduringtherequiredtimeframe,aregistrationholdwillbeplacedonthe

student'saccount. ArevisedprogramofstudymustalsobesubmittedviatheSISwhenany

change

in

the

original

plan

occurs.

Questions

about

the

PPOS

can

be

directed

to

the

Graduate

[email protected],(216)3684390.

RegistrationforclassesisalsodoneonlineinSIS.

MoststudentsarriveJuly1andimmediatelybeginalabrotation.Becausethesummersession

isnotencumberedbycoursework,oftenthisrotationisanexcellentlaboratoryexperience.In

theFall,studentsgenerallyenrollinthecorrelatedcurriculumincellbiology(CBIO453)and

molecularbiology(CBIO455)andpursuelabrotations.

StudentsarerequiredbytheUniversitytotake36semesterhoursofgraduatecoursesbefore

advancingtocandidacy;thisincludesrequiredcourses,advancedelectivesand601research.

Atleast24hoursmustbegraded.

NeurosciencesPh.D.ProgramRequirements:

CBIO453CellBiologyI

CBIO455MolecularBiologyI

IBMS500BeingaProfessionalScientist(Ethicalissuesinscienceresearchseminar)

NEUR402PrinciplesofNeuralSciences
http://www.case.edu/bulletin/mailto:[email protected]:[email protected]:[email protected]:[email protected]://www.case.edu/bulletin/


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9

NEUR415NeurosciencesSeminarSeries

NEUR540AdvancedTopicsinNeuroscienceEthics (Studentswhomatriculatedbefore2004

areexemptfromtakingthiscourse)

Electivegraduatecourses

NeurosciencesJournalClub

Aminimumof18hoursofNEUR701thesisresearch

SuggestedCourseofPh.D.Study

Year1Fall

CBIO453CellBiology1(4credits)

CBIO455MolecularBiology1(4credits)

NEUR601ResearchinNeuroscience(1credit)

Year1Spring

NEUR402PrinciplesofNeuroscience(3credits)

Electivegraduatecourse(23credits)

NEUR415NeuroscienceSeminars(1credit)

NEUR601ResearchinNeuroscience(23credits)

IBMS500Onbeingaprofessionalscientist(0credits,tobe

taken

in

May)

SummerCompletepreliminaryexambyJuly31

Beginthesisresearch

Year2Fall

Electivecourses(6credits)


Year2Spring

Elective

Courses

(6

credits)


CompleteQualifierExambyJuly31

Formthesiscommittee

Research

Prepareindividualfellowshipapplication

Year3Fall


ThesisCommitteeMeetingsevery6months

Year3Spring

NEUR540AdvancedTopicsinNeuroscienceEthics(0credits)

(Allstudentsmatriculatingin2004andlatermusttakethiscourse)


ThesisCommitteeMeetingsevery6months

Year4+

NEUR701ResearchinNeuroscience(1crediteachFallandSpringSemesteruntilgraduation)


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10

Thesiscommitteemeetingsevery6months

SummerSessions:Studentsmustregisterfor(0)credithoursofRSCH750(SummerResearch)

everysummerusingDeniseDouglasastheinstructor,unlessyouaregoingtodefendinthe

summer;inthiscase,pleaseseeKatie.

MedicalScienceTrainingProgram(MSTP)

MSTPstudentsintheneuroscienceprogramareexpectedtocompletetherequirementsfor

MSTPstudentsasoutlinedintheMSTPguidelines.Thegeneralguidelinesandperformance

expectationsforMSTPstudentsintheneuroscienceprogramareidenticaltothoseforgraduate

students.MSTPstudentsarerequiredtotakeNEUR402PrinciplesofNeuroscience,and3

otherelectivecourses,atleastoneofwhichisinNeurosciences.Studentsareencouragedto

takeNeurosciencegraduatecoursesduringthefirsttwoyearsofmedicalschool.Inparticular,

inlightofmedicalschoolcurriculumchanges,itisadvisedthatMSTPstudentscompleteNEUR

402duringyear1ofmedicalschool.Ingeneral,studentsareencouragedtotakeagraduate

schoolelectivecourseinyear2ofmedicalschool,whilealsopreparingfortheUSMLEstep1.

Preliminaryexamshavethesameformatasthatforothergraduatestudents,andshouldbe

completedinthefirstsummerfollowingidentificationofalaboratoryandmentor.The

qualifyingexamshouldbecompletedattheconclusionofrequiredcoursework,andmustbe

completedinthesecondsummerfollowingadmissionintothegraduateprogram.Inkeeping

withMSTPprogram,eachstudentmusthaveamemberoftheMSTPsteeringcommitteeand

oneMDorMD/PhD.onthethesiscommittee.TheMSTPsteeringcommitteememberfor

NeurosciencesisDr.JerrySilver(jxs10).

LaboratoryRotationsandSelection

Oneofthemostimportantdecisionsastudentmakesisthechoiceofafacultyadvisor.To

obtainexperienceindifferentlaboratories,studentscompleteaminimumofthreerotationsof

approximately

4

6

weeks

duration

during

the

first

semester.

Students

are

encouraged

to

start

rotationsJuly1toallowforthreeextendedrotationsbyDecember.Theserotationsgive

studentsadiverseintroductiontoapproachesforstudyingneuralfunctionandserveasthe

basisforchoosingalaboratoryforthePh.D.thesis.Astudentshouldrealizethat2025hours

perweekoflaboratoryworkareexpectedduringthesemester.A3pagerotationreport

describingtheprojectandarotationevaluationformmustbepreparedattheconclusionof

eachrotation.Aftertheformiscompleted,thestudentandfacultyadvisormeettodiscuss

comments.Copiesoftherotationreportandsignedevaluationformaresubmittedtothe

graduateprogramadvisor,theNeurosciencesOffice(givetoKatie),andtheBSTPOffice(for

BSTPstudents).Thisisthestudent'sresponsibility.

Bytheendofthefirstsemester,studentscommittoaspecificlaboratoryandfacultyadvisorfor

doctoralstudies.ThedateofthiscommitmentisgenerallyaroundDecember15. Anyfaculty

advisorwhoagreestotakearotationstudentmustdosoonlywithconfirmedfinancialsupport

shouldthestudentdecidetoworkinthatlaboratory.


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12/26

12

NEUR432:CURRENTTOPICSINVISIONRESEARCHCreditHours:3.0

Offeredalternatingyears,springsemester(lastofferedinspring2010).

Park,P.

Description:Visionresearchisanexcitingandmultidisciplinaryareathatdrawsonthedisciplinesofbiochemistry,

genetics,molecularbiology,structuralbiology,neuroscience,andpathology. Thisgraduatelevelcoursewill

providethestudentwithbroadexposuretothemostrecentandrelevantresearchcurrentlybeingconductedin

thefield. Topicswillcoveravarietyofdiseasesandfundamentalbiologicalprocessesoccurringintheeye.

Regionsoftheeyethatwillbediscussedincludethecornea,lens,andretina. Visiondisordersdiscussedinclude

agerelatedmaculardegeneration,retinalciliopathies,anddiabeticretinopathy. InstructorsinthecourseareexpertsintheirfieldandaremembersofthemultidisciplinaryvisualsciencesresearchcommunityhereatCase

WesternReserveUniversity. Studentswillbeexposedtotheexperimentalapproachesandinstrumentation

currentlybeingusedinthelaboratoryandinclinicalsettings. Topicswillbecoveredbytraditionallectures,

demonstrationsinthelaboratoryandtheclinic,andjournalclubpresentations. Studentswillbegradedontheir

performanceinjournalclubpresentations(40%),researchproposal(40%),andclassparticipation(20%).Cross

listedasPATH432andPHRM432.

NEUR435:VISION:MOLECULESTOPERCEPTIONCreditHours:3.0

Offeredalternatingyears,springsemester.

STAFF

Description:Theorganization,physiology,andfunctionofthevertebratevisualsystemareconsideredindetail.

ThevisualpathwayfromretinatoLGNandvisualcortexisdescribedwithanemphasisoncircuitsthatproduce

successivelymorecomplexreceptivefieldproperties.Classicpapersandcurrentliteratureformthebasiccourse

material.Assessmentisbasedonstudentpresentations,classparticipation,andatermpaper.Prereq:NEUR402

orconsentofdepartment.

NEUR440:SYNAPTICTRANSMISSIONCreditHours:3.0

Offeredspringsemester,basedonstudentinterest.

STROWBRIDGE,B.

Description:Thiscoursewillexplorethebasicmechanismsofsynaptictransmissionthatoperateatcentraland

peripheralsynapses.Studentswillreadandpresentamixtureofhistoricalandmodernpapersthatestablishedthe

fundamentalprinciplesofsynaptictransmissionandplasticity.Thecoursewillbeginwithabriefreviewofcellular

neurophysiologyandthetechniquesusedtostudysynapticpotentials.WewillthenreadclassicpapersbyKatzand

colleaguesthatdefinedthemechanismscontrollingtransmitterreleaseattheneuromuscularjunction.Nextwe

willconsidertheroleofcalciuminregulatingthereleaseofneurotransmittersandinshorttermmodulationofsynapticpotentials.Wewillthenexplorepre andpostsynapticprocessessuchasreceptorsaturationandvesicle

dynamicsthatgoverntheamplitudeandtimecourseofpostsynapticpotentials.Quantalanalysisandsilent

synapseswillbediscussedinthecontextofthepresentdaycontroversiesregardinglongtermpotentiationat

centralsynapses.Wewillalsoconsidertherelationshipbetweenshort andlongtermsynapticplasticityand

behavioralfunctionssuchaslearningandmemory.Occasionalfacultylectureswillcomplementstudent

presentationsonprimaryresearcharticles.Studentgradeswillbebasedontwoshort(5page)essaysandclass

participation.Prereq:Permissionofthecoursedirector.

NEUR473:INTRODUCTIONTONEUROBIOLOGYCreditHours:3.0

Offeredeveryfallsemester.

CHIEL,H.

Description:Hownervoussystemscontrolbehavior.Biophysical,biochemical,andmolecularbiologicalproperties

ofnervecells,theirorganizationintocircuitry,andtheirfunctionwithinnetworks.Emphasisonquantitative

methodsformodelingneuronsandnetworks,andoncriticalanalysisofthecontemporary technicalliteraturein

theneurosciences.Termpaperrequired.Twolecturesperweek.Prereq:Consentofdepartment.Crosslistedas

BIOL473

NEUR474:NEUROBIOLOGYOFBEHAVIORCreditHours:3.0


RITZMANN,R.

(SeeBIOL374).CrosslistedasBIOL474.


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13

NEUR476:NEUROBIOLOGYLABORATORYCreditHours:3.0


WOOD,D.


NEUR478:COMPUTATIONALNEUROSCIENCECreditHours:3.0

Offeredalternatingyears,springsemester(lastofferedinspring2006)

THOMAS,Peter(MATHEMATICS)

Description:Computersimulationofneuronsandneuralcircuits,andthecomputationalpropertiesofnervous

systems.Studentsaretaughtarangeofmodelsforneuronsandneuralcircuits,andareaskedtoimplementandexplorethecomputationalanddynamicpropertiesofthesemodels.Thecourseintroducesstudentstodynamical

systemstheoryfortheanalysisofneuronsandneuralcircuits,aswellastocabletheory,passiveandactive

compartmentalmodeling,numericalintegrationmethods,modelsofplasticityandlearning,modelsofbrain

systems,andtheirrelationshiptoartificialneuralnetworks.Termprojectrequired.Twolecturesperweek.Cross

listedwithEECS478&BIOL478.

NEUR479:SEM:COMPUTATIONALNEUROSCIENCECreditHours:3.0

Offeredalternatingyears,springsemester(lastofferedinspring2005)

BEER,R.andCHIEL,H.

Description:Readingsanddiscussionintherecentliteratureoncomputationalneuroscience,adaptivebehavior,

andothercurrenttopics.CrosslistedasBIOL479.

NEUR482:

DRUGS,

BRAIN,

AND

BEHAVIOR

CreditHours:3.0Offeredeveryspringsemester.

WOOD,D.


NEUR518:SIGNALINGVIACELLADHESIONCreditHours:3.0

Offeredalternatingyears,springsemester(lastofferedinspring2006).

BRADYKALNAY,S.

(SeeMBIO518).CrosslistedasMBIO518.

NEUR540:ADVANCEDTOPICSINNEUROSCIENCEETHICSCredithours:0.

Offeredeveryotherspringsemester(beginning2008)Studentswhomatriculatedbefore2004areexemptfrom

takingthis

course).

Strowbridge,B.W.andZigmond,R.E.

Description:Thiscourseofferscontinuingeducationinresponsibleconductofresearchforadvancedgraduate

students.Thecoursewillcovertheninedefinedareasofresearchethicsthroughacombinationoflectures,online

coursematerialandsmallgroupdiscussions.Six2hrmeetingspersemester.Maximumof15studentswith

preferencegiventograduatestudentsintheNeurosciencesprogram.AllNeurosciencesgraduatestudents

matriculatingin2004andlatermustcompletethiscourse(typicallyduringtheir3rdor4thyearintheprogram.)

NEUR601:RESEARCHINNEUROSCIENCECreditHours:1.0 18.0

NEUR651:THESISM.S.CreditHours:1.0 6.0

(Creditasarranged).Prereq:M.S.candidatesonly.

NEUR701:

DISSERTATION

PH.D.

CreditHours:1.0 18.0

ResponsibleConductinResearch.Allstudentsarerequiredtocompletethecourse,

IBMS500:ONBEINGAPROFESSIONALSCIENTISTattheendofthefirstyearofstudy.This

coursethatoutlinesfundamentalinformationandsomecasestudiesisgenerallypresentedin

oneweekinMay.Asecondresponsibleconductcourse,NEUR540:ADVANCEDTOPICSIN

NEUROSCIENCEETHICSwillbecompletedinthethirdorfourthyearofgraduatestudy(spring

semesters)andengagesmoredetaileddiscussion.Students,postdocsandfacultyare


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14

encouragedtoparticipateinmonthlyworkshopspresentedbytheOfficeofResearch

Compliance(http://ora.ra.cwru.edu/research/orc/rcr/index.cfm;workshopcalendarat

http://ora.ra.cwru.edu/research/orc/education/onlinecalendar.cfm).

Examinations

ProgresstowardthePhDismarkedbygradesincoursework,laboratoryresearchandsuccessful

completionofexams.Universityregulationsregardingqualitypointaverageandacademic

probationformtheminimumexpectationsofourstudents.Anystudentwithaqualitypoint

averagebelow3.0attheendof2ndor4thsemestersofgraduatestudymaybeseparatedfrom

theUniversitybyamajorityvoteoftheprimaryfacultyintheDepartmentofNeurosciences.

PreliminaryExamendoffirstyear.Thegoalofthisexamistoidentifystudentswhoexhibit

significantgapsinbasicknowledge.Thestudentisgivenaprimaryresearcharticleselectedby

thefacultyadvisor.TheadvisorandtwoadditionalNeurosciencetrainingfacultywhoare

selectedbyrotationfromalistofalltrainingfaculty(seeNarleneBrowntodeterminethe

compositionofyourcommittee)formanexaminationcommittee.Thechairofthecommittee

mustbeaprimaryfacultymemberintheNeurosciencesDepartment.Oneweeklaterthe

studentmakesa30minpresentationincludingrelevantbackground,descriptionofthe

experiments,andacritiqueoftheresultsanddiscussion,andthestudentwillbebroadly

questionedinanexamthattypicallytakes1.5hours.Studentsshouldpracticetheir

presentationstoensurethatthepresentationtimelimitisfollowed.Thestudentisnotrequired

todiscussallfacetsofthepaperbutshouldemphasizeitsimportantaspects.Successful

completionoftheexamisrequiredforprogressiontothesecondyearofgraduateschool.A

personalizedcourseofstudymayberecommendedifnecessary.Theexamcommitteechairwill

submitawrittenreportwithinoneweektotheGraduateProgramAdvisor.Theexammustbe

completedbyJuly31ofthefirstyearofstudy.

QualifyingExamendofsecondyear.Thisexamconstitutesacriticalmilestoneingraduate

training.

It

tests

the

ability

of

a

student

to

identify

an

important

problem

and

propose

creative

andfeasiblesolutions.Afourmembercommitteewillbedeterminedbythefacultyadvisorand

studentandmustincludeatleasttwoNeurosciencestrainingfaculty.Iftheadvisorisnota

primaryNeurosciencefacultymember,thecommitteemustbeconstitutedofatleast3primary

facultymembers,outofwhich,onemustbeamemberoftheGraduateEducationCommittee,

andtheadvisor.Thechairoftheexamcommitteemustbeaprimaryfacultymemberinthe

NeurosciencesDepartment.Atopicforaminigrantproposal,clearlydistinctfromthestudent's

andsponsoringlab'sresearchprojectwillbeselectedbythefacultycommitteeandgiventothe

student.Thequalifyingexamcommitteeisresponsibleforinsuringthattheexamtopicis

appropriatelydistinctfromthestudentsthesiswork.

Oneweekafterreceivingthetopic,thestudentwillsubmitspecificaimsfortheproposalthat

mustbeapprovedbythecommittee.Threeweekslater(4weekstotal),thestudentwillsubmit

tothecommitteea10pageresearchproposal(Approx.3pagesintroduction,background&

significanceand7pagesspecificaimsandexperimentaldesign).Theproposalshoulddescribe

13experimentsthatarefeasiblewithina3yeartimeinterval.Questionsaboutthetopic

shouldbedirectedtomembersofthestudent'sexaminationcommitteeandnottoother

facultyorstudents.Oneweekaftersubmittingtheproposalthestudentwillgiveanoral

presentationtothecommitteeanddefendtheproposal.Copiesofthedocumentsthat

supportedsuccessfulexamsareavailableforstudentstoview(seeKatie).Ifthestudentfails,
http://ora.ra.cwru.edu/research/orc/rcr/index.cfmhttp://ora.ra.cwru.edu/research/orc/education/onlinecalendar.cfmhttp://ora.ra.cwru.edu/research/orc/education/onlinecalendar.cfmhttp://ora.ra.cwru.edu/research/orc/rcr/index.cfm


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15

thecommitteemaygivethestudentasecondattempttopasstheexam.Thechairwillsubmita

reporttotheGraduateProgramAdvisorwithinoneweek.Thisexamshouldbecompletedby

July31ofthesecondyearofstudy.Satisfactoryperformanceonthisexamwilladmitthe

studenttoCandidacyforthePh.D.inaccordancewithUniversityguidelines.

ChangeofStateNotification.Thegraduateschoolrequireswrittennotificationofevery

advancementinagraduatestudent'sprogresstomarkeachofthefollowingevents1)selection

ofresearchadvisor2)selectionofthesiscommitteemembers3)successfulcompletionof

qualifyingexam4)successfulcompletionofPh.D.program.StudentsshouldemailKatieWervey

(kar18)toletherknowtheseadvancementshavebeenachieved.

ResearchIntegrity.Studentsshouldcarefullyattributematerialgeneratedbyothers.Asa

generalworkingdefinition,theOfficeofResearchIntegrityconsidersplagiarismtoincludeboth

thetheftormisappropriationofintellectualpropertyandthesubstantialunattributedtextual

copyingofanotherswork.Itdoesnotincludeauthorshiporcreditdisputes.Substantial

unattributedtextualcopyingofanothersworkmeanstheunattributedverbatimornearly

verbatimcopyingofsentencesandparagraphswhichmateriallymisleadtheordinaryreader

regardingthecontributionsoftheauthor.ORIgenerallydoesnotpursuethelimiteduseof

identicalornearlyidenticalphraseswhichdescribeacommonlyusedmethodologyorprevious

researchbecauseORIdoesnotconsidersuchuseassubstantiallymisleadingtothereaderorof

greatsignificance.Formoreinformationonthisissue,see

http://ori.dhhs.gov/policies/plagiarism.shtml

GUIDELINESFORTHESISRESEARCH

A. GoalsforGraduateStudents:Studentsmuststrivetodevelopwiththeadvisoraresearchprojectthatyieldsacoherentand

original

body

of

work.

Thethesismustbewritteninascholarlymannerwithadetailedhistoricalintroductionanda

criticaldiscussion.

Thefirstdraftofthethesismustbetheoriginalandindividualeffortofthestudent.Thedraft

submittedtotheThesisCommitteeshouldbeapolisheddocumentdevelopedin

consultationwiththementor.

Ingeneral,thethesisresearchshouldutilizemorethanonetechnicalapproach.Inthethesis

document,thesisseminar,andthesisdefense,thestudentshoulddemonstratethat

he/shehasbecomeanexpertinthefieldofresearch.

Bythetimeofthethesisexamination,thestudentshouldhavesubmittedforpublicationat

leastonepeerreviewedexperimentallybasedmanuscriptonwhichhe/sheisthefirst

authorandhavecompletedabodyofworkthatthestudent'scommitteejudgeswill

leadtoasecondmanuscript,andadraftofthesecondmanuscriptshouldbecompleted.

Thefirstdraftofallmanuscriptsshouldbewrittenbythestudent.

Duringthecourseofstudy,studentsshouldpresenttheirdataat,atleastonenationalmeeting.

B. GoalsfortheTrainingFaculty:TrainingfacultyofPh.D.studentsmustbeactiveparticipantsintheNeurosciencesProgram

andcontributetocourses,collaborativeresearchprojectsand/orjournalclubs.The


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17/26

17

meetingshouldendwiththedevelopmentofaconsensusplanforthenext6months.

Subsequentmeetingsshouldputnewworkinthecontextoftheentireproject,andoutline

advancesandproposedareasforwork.Thecommitteechairmustsendashortsynopsisofthe

meetingtotheGraduateProgramAdvisorandNeuroscienceDepartmentalAssistantwithinone

week.

TheThesisCommitteemustmeetatleastonceasemestertomonitorstudentprogress.Itisthe

responsibilityofboththeChairoftheCommitteeandthestudentthatthesemeetingstake

place.StudentswillnotbeallowedtoregisterforasemesteriftherehasnotbeenaCommittee

meetingduringtheprevioushalfyearperiod.

Atleasttwoweekdayspriortoeachmeeting,abriefwrittensummaryofthestudent'sprogress

sincethelastmeetingshouldbegiventoeachcommitteemember.Itistheresponsibilityof

committeememberstoreadthereportpriortothecommitteemeeting.

Aftereverymeeting,adateforthenextmeetingwillbesetfor6monthslater(unlessdirected

bythecommitteetomeetsooner),sothatthestudentandcommitteememberscanenterit

intotheircalendars.Itisveryimportantthatstudentsandtheircommitteesmeetevery6

months,even

if

thestudent

does

not

feel

he

or

she

has

enough

data

to

report,

so

thatthe

committeecanbekeptuptodateonhisorherprogressandcanadvisethestudent.

TheThesisCommitteeevaluatesthestrengthsanddeficienciesinthetrainingplanorinits

implementationanddiscussesthesewiththementorandstudent.TheCommitteeshouldserve

asasoundingboardifthestudentencountersproblemsinthegraduateprogramandshould

createarelationshipwiththestudentwhereitisclearthatsuchinterchangesareencouraged.

TheCommitteeisresponsibleforseeingthatthestandardsandtherequirementsofthe

programarefulfilled.ItisultimatelytheresponsibilityoftheChairoftheCommitteetobring

any

unresolved

problems

to

the

attention

of

the

Director

of

Graduate

Studies

and/or

the

DepartmentalGraduateEducationCommittee.

ProgressReportsmustbecompletedwithinoneweekofthecommitteemeetingandsentto

themembersofthecommitteeandtotheDepartmentalAssistantforplacementinthe

studentsconfidentialfolder.Thereportmustcontainaclearassessmentofwhetherornot

satisfactoryprogressisbeingmadetowardsaPh.D.degree.Thisassessmentisoneofthekey

responsibilitiesoftheAdvisoryCommittee.Ifthestudentreceivestwounsatisfactorygradesin

NEUR701,thestudentisseparatedfromtheUniversity.

Ifthestudent,mentorandcommitteecannotcometoanagreementaboutthetrainingplan,

theyshouldbringtheirdifferencestotheDepartmentalGraduateEducationCommittee(*see

underStudentAdvocatesnextsection),theGraduateProgramAdvisor,ortheChairofthe

Department.

TheThesisCommitteeisresponsibleforapprovingtheshiftinthestudentsprioritiesfrom

doingexperimentstowritingthethesis.Beforedoingthis,thestudentmustpresenttothe

Committeeabriefoutlineoftheproposedwrittenthesis.


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TheDissertation

AllcandidatesforthePhDdegreemustsubmitawrittendissertationasevidenceoftheirability

toconductindependentresearchatanadvancedlevel.Thedissertationmustrepresenta

significantandoriginalcontributiontoexistingknowledgeinthestudent'sfield.Atleastsix

monthsbeforethestudentanticipatesPhDcompletion,athesiscommitteemeetingshouldbe

heldtodiscusswhetherthestudent'sprogresstowardthedegreeissufficient.Thecommittee

shouldagreeatthattimetotheformatofthethesis.Itisinastudent'sinteresttosubmitany

manuscriptsbeforeleavingtheUniversity,becauseonceapostdoctoralpositionisbegun,other

concernsarise.Becausemanystudentshavepublishedmanuscriptsontheirstudies,thethesis

oftenreflectsthatworkaschapters,placedincontextwithageneralIntroduction,anda

Discussionthatconsiderstherelevanceofthestudies.Theformofthethesisisnotproscribed

bythedepartment,butisarrivedatbythestudentandthesiscommittee.Examplesof

NeurosciencegraduatethesesareintheNeurosciencelibrary.Detailedregulationsconcerning

format,quality,timeofsubmissionandoraldefenseareestablishedbytheDeanofGraduate

StudiesandResearch,andinstructionsareavailablefromtheOfficeofGraduateStudies.

StudentAdvocates.Intheeventthatdifficultiesariseduringgraduatetraining,astudentis

advisedtoseekadvicefromoneormoresourcesincludingthestudent'sfacultyadvisor,the

graduateprogramadvisor,theGraduateEducationCommittee,thedepartmentalchairperson

orifrelevant,theMSTPdirector.TheGraduateEducationCommitteewithintheDeptof

NeuroscienceswillmeetonanadhocbasistodiscusspolicyissuesinGraduateEducation.A

graduatestudent,thesisadvisor,Committeemember,orGraduateProgramAdvisorcanbring

totheCommitteeatanytimecaseswhereseriousbreakdownsincommunicationhave

occurredwithrespecttothestudentsgraduatestudiesandasktheCommitteetointervene.

MembersoftheGraduateEducationCommitteeincludeDrs.RichardZigmond,AlisonHall,

StefanHerlitze,DavidKatz,andBenStrowbridge(CommitteeChair).Studentsarealso

encouragedtoseekadvicefromtheDirectorofGraduateEducation,Dr.AlisonHall,inTG1,

whowillworktoeffectresolution.Ifnecessary,studentsmayexpressagrievanceagainst

actions

of

students

or

faculty

and

staff

through

procedures

handled

by

Graduate

Studies

(for

academicproblems)ortheUniversityOfficeofStudentAffairs(fornonacademicproblems).

MembersoftheUniversitycommunitywhobelievetheyhavebeensexuallyharassedare

entitledtoaninvestigation;officialsintheProvost'sOffice,OfficeofStudentAffairsand/orthe

OfficeofAffirmativeAction/EqualEmploymentOpportunitywillprovideoptionsforresolution.

MasterofNeuroscienceDegree.TheNeuroscienceprogramisaDoctoraldegreegranting

programanddoesnotofferaMastersofSciencecurriculum.Nostudentwillbeadmittedto

theProgramforthesolepurposeofearningaM.S.degree,andundernocircumstanceswilla

MastersdegreebeawardedaspartofaDoctoralcurriculum.Onrareoccasions,however,an

individualmayleavetheDoctoralprogramaftercompletingasignificantbodyofcoursework

andindependentresearch.Undertheseconditions,aMasterofNeurosciencedegree(TypeB)

maybeawardedundertherecommendationofthestudent'sthesisorqualifyingcommittee.To

completetherequirementsforaMasterofNeuroscience,astudentmustmaintaincontinuity

ofregistrationandaminimumcumulativegradepointaverageof2.75(seeGraduateStudent

Handbook,pg.17).Thestudentmustsuccessfullypassthepreliminaryexamaswellasaspecial

Mastersqualifyingexam,andhavecompletedatotalof27semesterhoursofcoursework. At

least18hoursofcourseworkmustbeatthe400levelorhigher.Anyrequirementsnot

specificallyaddressedbelowsuchasthosepertainingtogradepointaverage,residencyand

feesconformtotheregulationsfortheMastersdegreespecifiedinthegeneralUniversity


19/26


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20

LeicaTCSSP2MPconfocal/multiphotonandtheBioRadRadiance2100multiphotonlaser

scanningsystem.TheNeurosciencesdepartmenthasoneofthelargestconcentrationsof2

photonmicroscopesinthecountry(theBioRad2100MPandLeicaTSCSP2MPintheNICand

twocustomsystemsintheStrowbridgelaboratory).

TheZeissLSM510METAistheprimaryconfocalmicroscopetheNIC.Itcanbemountedon

eitheramotorizedinvertedstand(Axiovert200M)oramanualuprightstand(AxioImagerZ1).

Thesystemofferseightexcitationwavelengths(405nm,458nm,477nm,488nm,514nm,

543nm,594nmand633nm)andfordetection,threeseparatereflectedlightPMTs,eachwith

itsownadjustablepinholeandemissionfilterwheel.TheLSM510METAscanheadcanacquire

lambdastacksin10nmincrementsoverabroadspectralrange(411753nm).Alambdastack

collectedfromindividualreferencedyescanbeusedtogenerateanemissionfingerprintthat

cansubsequentlybeusedforspectralunmixingofcloselyrelateddyesandisoftenusedto

separatedifferentGFPvariants.Fourcommonlyusedsoftwaremodules(Multitime,

Physiology,FRETandFRAP)areavailableforonlineimaging.Tofacilitatelivecellimaging,a

BiopticsDeltaT4heatingstageandobjectiveheatercanbeusedwithboththewidefieldand

confocalsystemswithinthefacility.

AZeissLSM

410

confocalmicroscope,thepredecessortotheLSM510,isalsoavailableforuse

atareducedhourlyrate.ThesystemconsistsofanLSM410scanheadmountedonaninverted

Axiovert100microscopestandandoffersfiveexcitationwavelengthsandfordetection,three

separatePMTs,eachwithitsownadjustablepinholeandemissionfilterwheel.Despiteitsage,

thissystemremainsinexcellentcondition,iseasytouse,andisoftenavailablewhenthe

LSM510isfullybooked.TheLSM410islocatedinitsownroom(E638).

TheBioRadRadiance2100MPisadedicated2photonlaserscanningsystemattachedtoan

uprightmicroscope.2photonmicroscopyidealforimagingthroughliveorfixedbraintissue,

therebyavoidingtheneedtoresectiontissueforconfocalmicroscopy.2photonimagingalsois

well

suited

to

image

living

specimens

since

it

generates

much

less

phototoxicity.

Both

the

Leica

TCSSP2MPandtheBioRad2100MPcanperform2photonimaging.SincetheLeicasystemis

basedonaninvertedmicroscope,itiseasiertouseforliveculturecellswhiletheBioRad

systemismoreconvenientforintactorsemiintacttissue.TheBioRadsystemalsoisequipped

forpatchclampelectricalrecordingsandcanbeusedforbrainsliceexperiments.

TheLeicaTCSSP2MPconfocal/multiphotonmicroscopecombinesspectrophotometric

detectionwithconfocaland2photonmicroscopy.Insteadoftraditionaldichroicfiltersets,a

prismisusedtoseparatetheemittedfluorescence,resultinginaveryflexibleandefficient

detectionsystem.Forexcitation,thesystemofferssixvisiblelightwavelengths(458nm,476nm,

488nm,514nm,543nm,and633nm)plusatunable(720nm950nm)IRlightsource(Choherent

ChameleonXRMPlaser)for2photonexcitation.Whilethissystemhasmanyadvanced

features,itstillcanbeusedasageneralpurposeinvertedconfocalmicroscope.Itislocatedin

itsownroom(E639).

AnotherZeissinvertedmicroscopestandisequippedforTIRF(TotalInternalReflection

Fluorescence)imaging.ThissystemismountedonaZeissAxiovert200Mmicroscopeand

includesa100mWmultiline(458nm,488nm,and514nm)Lassos77laserandahighNA(1.45)

100x planFLUARobjective.Theevanescentfieldformedbythissystemcanvarybetween60

330nmandisabletoexcitedyesinanaqueousenvironmentatornearthecoverglass/cell


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21

interface.Thissystemisdesignedtoimagefluorescencelabelsinorverynear(withinafew

hundrednm)theplasmamembraneinculturedcells.

WealsooperateageneralpurposeInvertedWideFieldMicroscopethatintegratesaZeiss

Axiovert405microscopewithsoftware,computersandcameras.Thesoftware(Metamorph

andMetafluor)isdesignedtosupportimageacquisition,morphometricanalysis,calciumratio

imaging,3Dreconstruction,andtimelapseexperiments.Tofacilitatelivecellimaging,a

BiopticsMtypestageheaterandadjustableobjectiveheaterareavailableforusewiththis

system.

TheNeurolucida3DreconstructionandstereologysystemisbasedonaZeissAxioplanupright

microscopewithahighresolutionmotorizedstageandisdesignedtofacilitatethree

dimensionaltracingsandreconstructionsofneuronsfilledwithfluorescentoropaquedyes.In

additionthesystemoffersaseparatestereologypackagethatallowstheusertoestimatecell

numberandmorphologicalpropertiesof3Dstructuresfrom2Ddata.

TheBioRadmodel3000VersadocGelImagingSystemisdesignedtocaptureandanalyze

digitalimagesfromawiderangeofsamples,includinggels,blots,autoradiograms,TLCplates

andmicroplates.Thesystemisabletodetectandquantifystandardnucleicacidandprotein

specificstainsaswellaschemiluminescent,chemifluorescent,colorimetric,andfluorescent

samples.

ThedepartmentsComputerLabisalsolocatedintheNeuroscienceImagingCenter,room

E632b.ItincludesMacintoshandPCworkstationsloadedwithsoftwarefordataanalysis,

manuscriptpreparation,andimageprocessing.AnofflineversionoftheLSM510software,

Release3.5isavailableonthePCcomputer.PeripheralequipmentincludesPolaroid5000and

6000slidemakers,anEpsonStylusPhoto2200printer,andaMicrotekscannercapableof

scanningbothreflectiveandtransparentimages.Foradditionalinformation,pleasecontact

Maryanne

Pendergast

(mxp19,

office:

368

2575

or

cell:

216

224

8649).

PHOTOGRAPHYSUITE.Apointlightsourceenlarger,adiffuselightsourceenlarger,rapid

processorsandahighqualitycopystandareprovidedintheE630darkroomsuite.For

informationortrainingcontactMaryannePendergast(mxp19x2575).

ICYCLER.

LocatedintheZigmondLab,roomE734a

TheBioRadiCycleriQPCRdetectionsystemallowstheusertobothmonitorandquantifya

PolymeraseChainReaction(PCR)inrealtime.Abroadspectrumtungstenlightsourceand

multiplefilterspermitawiderangeofexcitationandemissionbetween400700nm,andalso

themultiplexingofuptofour(4)differentreporterfluorophors.Onlinedisplayallowsvisual

confirmationofthePCRamplificationinprogress,anda350,000pixelCCDdetectormakes

possiblethesimultaneousdetectionofupto96samples.Forinformationortrainingcontact

RichardZigmond(rezx4614).


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22

CASERODENTBEHAVIORCORE.

CoreDirector:GemmaCasadesus(gxc40x8503).

http://neurosciences.case.edu/crbc/index

ThegoaloftheRodentBehaviorCoreintheSchoolofMedicineistoconductstateoftheart

rodentbehavioraltestingforinvestigatorsatCaseandothernearbyinstitutions.Thecore

facilityisequippedtoperformacomprehensivebatteryofbehavioralteststothoroughly

phenotypeoverallmotorandsensoryfunctionofratsandmiceaswellasphenotypespecific

behaviorsthatareofinteresttotheinvestigators(learningandmemory,motorfunctionand

gaiting,place/fearconditioning,pain/analgesia,andanxietyrelatedbehaviors).TheCorecan

assistinallaspectsofrodentbehavioraltestingincludingdesignandexecutionofbehavioral

tasksaswellasdataanalysisandinterpretation.TheCorelaboratoryistemporallylocatedin

theWolsteinBuildingbutwillexpandtoitsmainlocationinthenewlyrenovatedAnimal

ResourceCenter(ARC)inNovember2007.

OTHERFACILITIES/SERVICES

ELECTRONMICROSCOPYFACILITY.

Director:Dr.HisashiFujioka(hxf3x2490)

TrainingandFacilityManager:MidoriHitomi(mxh67x3454)

InstituteofPathology(IPRoom116)

TheelectronmicroscopyfacilityincludesJEOL1200EXtransmissionelectronmicroscope,afully

equippedsampleprocessinglaboratory,asectioningroom,andadarkroom.Forinformation,

contactMidoriHitomi.

ANIMALFACILITY.Allindividualsinvolvedinresearchusingvertebrateanimalsarerequiredto

betrainedandtobelistedonanapprovedanimalprotocol.Theseindividualsmustreadand

signtheprotocol.InformationaboutanimalresearchatCWRUisavailableat

http://casemed.case.edu/ora/iacuc/.

BASICSCIENCEINSTRUMENTATIONREPAIRFACILITY.

WilliamM.Frank,Manager(wmf3x3225).

(SOM,B05atthebasementintersectionofWood,Tower,East,andBRB).

http://casemed.case.edu/sirc/default.htm.

Mechanicalandelectricaldiagnosisandrepairofgeneralandspecializedlaboratoryequipment,

equipmentdesignandmodification,fabrications,retrofitting,reconditioningofolder

equipment.

VENDORS.Selectedvendorshavecommonlyuseditemsandspecialordersatfacilitieson

campus,administeredbydepartments:

Gibco/BRL/Invitrogen,PharmacologyW361

BoehringerBiochemistryW450

NewEnglandBiolabs,BiochemistryW450

Fisher,BRB547
http://casemed.case.edu/sirc/default.htmhttp://casemed.case.edu/sirc/default.htm


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23

UsefulWebsites:

TheNationalAssociationofGraduateProfessionalStudents

http://www.nagps.org/

JohnsHopkinsPostdoctoralAssociation

http://www.med.jhu.edu/jhpda

Sciencenextwave

http://nextwave.sciencemag.org/uk

SocietyforNeurosciences

http://www.sfn.org

AmericanSocietyforCellBiology

http://www.ascb.org/

FASEB

http://www.faseb.org

AssociationforNeuroscienceDepartmentsandPrograms

www.andp.org

NationalScienceFoundation(NSF)

http://www.nsf.gov/

DepartmentofHealthandHumanServices

http://www.os.dhhs.gov/


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24

CurrentStudentsintheNeurosciencesGraduateProgram(2010)

Name Yearenteredintoprogram

BrentCameron 2008

GermanCardenasLeroy 2009

PaigeCramer 2007

MarcDePaul 2009

RishiDhingra 2008YiDong 2006

TeresaEvans 2009

Angela(Nord)Filous 2008

StephanieFox 2004

DavinaGutierrez 2003

RobertHyde 2008

RebeccaJames 2008

KseniaKastanenka 2006

HyunjinKim 2008

BradleyLang 2009

ChungYingLee 2006

SunghoLee 2009

ChenLiu 2003

ShwetaMandrekar 2005

Crystal(Kozora)Miller 2005

InnaNechipurenko 2005

EugeneOh 2005

JoannaPucilowska 2007

PavelPuzerey 2009

JulieSavage 2008

LorenSchmidt 2008

MariaSmith 2005

YiLanWeng 2006

StevenWyler 2009

ElizabethYoung 2005

IsaacYoungstrom 2009


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25

AlumnioftheNeurosciencesProgramNamePresentPosition

XingbinAi,Ph.D.1999AssistantProfessor,Medicine,BostonUniversityMedicalCampus

MeredithAlbrecht,MSTP,PhD1999StaffAnesthesiologist,MassachusettsGeneralHospital

KatherineAlex,PhD2006VisitingAsst.Prof.,OberlinCollege

AgnieszkaBalkoweic,Ph.D.Asst.Prof.,Univ.ofOregonHealthSciencesCtr.

RamaniBalu,MSTP,PhD2006Resident,Neurology,UniversityofPennsylvania

KarenBaracskay,PhD2002ResearchFellow,Molecular&BehavioralNeurosciencesInst.,MentalHlth.Res.Inst.,Meador

WoodruffLa.,UofMichigan

BrianBlock,MDPh.D.1996Instructor,Partner,PainMed.Specialists(PrivatePractice);Dept.Anesthesiology&CriticalCare,

JohnsHopkinsUniv.

KristenBoeshore,Ph.D.1999AssistantProfessor,Biology,LebanonValleyCollege,PA

TheresaAnnBrosenitsch,PhD2001Faculty,Dept.ofMedicine,Univ.ofPittsburgh

SueBurdenGully,Ph.D.ResearchAssoc.,CWRU,MolecularBiology&Microbiology

SarahBusch,Ph.D. 2009PostdoctoralFellow,CWRUNeurosciences,SilverLab

Christy(Gray)Butler,MSTP,PhD2007Resident,Anesthesiology,JohnsHopkinsUniversity

DavidCanning,Ph.D.Asst.Prof.MurrayStateUniversity,KY

LingCheng,PhD2004UCSanFrancisco,PI:G.Davis

ElizabethChiang,MSTP,PhD2007CWRUMedicalSchool

StephenColgrove,M.S.2001Unknown

ColinCombs,Ph.D.Assoc.Prof.U.NorthDakota

AndrewCordle,MSTP,PhD2005Resident,OrthopedicSurgery,ClevelandClinic

Bethany

Cruise,

PhD

2004

Analyst,

Decision

Resources,

Boston,

MA

StephenDavies,Ph.D.Assoc.Prof.,Univ.ofColoradoHealthSciencesCtr.

DavidDewitt,Ph.D.1996Dir.,Ctr.forCreationStudies,AssociateProfessor,LibertyUniversity,KY

ChristopherB.Eckman,PhD2000Professor,MolecularNeuroscience,MayoClinic,Jacksonville

SonyaEnsslen,PhD2004PostdoctoralFellow,DanielJayLab,Physiology,TuftsUniversitySchoolofMedicine

GuopingFan,Ph.D.AssociateProfessor,HumanGenetics,DavidGeffenSchoolofMedicineatUCLA

MichaelFitch,MSTP,PhD1999Asst.Prof.,EmergencyMed.,WakeForestUniv.BaptistMed.Ctr.;Director,EDSimulationProg.;

Member,WFUCoreTeachingFaculty;NeuroscienceProgramFaculty

NicoleFrancis,Ph.D.2000Asst.Prof.ofMolecular&CellularBiology,HarvardUniversity

MollyFuller,MSTP,PhD2007MDIntern,Ophthalmology,UniversityHospitalsHealthSystems

DmitryFyodorov,Ph.D.1999Asst.Prof.ofCellBiology,AlbertEinsteinCollegeofMedicine

LiminGao,PhD2006Homemaker

YuanGao,PhD2009ResearchAssociate,CWRUNeurosciences,StrowbridgeLab

AndrewGarnerMDPh.D.1996InstructorinPediatrics,CWRU,UniversityHospitalsHealthSystems

LauraGault,MSTP,PhD1997Assoc.Res.Scientist,ChildStudyCtr.,YaleSchoolofMedicineEdwardGilmore,MSTP,PhD1999InstructorinPediatrics,PediatricsChildrensHospital,Harvard

NadineGoodman,Ph.D.ScienceTeacher,GilmourAcademy

GuyGuidry,Ph.D.1999Deceased

BrianHalabisky,PhD2003PostdoctoralFellow,GladstoneInstituteofNeurologicalDisease,LiGanLab,UCSF

AlisonHall,PhD,Professor,Neurosciences,CWRU;Director,OfficeofGraduateEducation,SchoolofMedicine,CWRU

JingHan,PhD2007PostdoctoralAssociate,MolecularandHumanGenetics,ZhogbiLab,BaylorCollegeofMedicine

MartinGartzHanson,PhD2004PostdoctoralFellow,Univ.ofColoradoHealthScienceCtr.,Denver

AliciaHawthorne,PhD2009PostdoctoralFellow,TheOhioStateUniversity,PhillipPopovichlab

JeannetteHayes(Davies)Ph.D.Asst.Prof.,Neurosurgery,Univ.ofColoradoHealthScienceCenter,Denver

CarolHaney,Ph.D.1999Unknown

TimHendricks,PhD2003PostdoctoralFellow,SalkInstitute,MartinGouldingLab

LibinHo,PhD1997InternalMedicinePediatricsandAdolescentMedicine,DeanHealthSystem,Madison,WI

KevinHorn,Ph.D.2009MedicalSchool TheOhioStateUniversity

QingguangJiang,PhD2008Postdoc,JohnsHopkinsU.,Dr.DavidGintyLabKristinLongKaelber,MSTP,PhD.PrimaryCarePhysician,CambridgeHealthAlliance;InstructorinMedicine,HMS

PaulKammermeier,Ph.D.1997Asst.Prof.Pharmacology&Physiology,U.RochesterSchoolofMedicineandDentistry

ShiChuKao,Ph.D.,2001StaffScientist,Clonetech

AmberKerstetter,PhD2009PostdoctoralFellow,CaseWesternReserveUniversity,ErinLavikLab

JessicaKoenigsknechtTalboo,PhD2005AssistantDirectorforDevelopment,WashingtonUniversityMedicalSchool

KatherineKrueger,PhD2008PostdoctoralFellow,NorthernCaliforniaInst.forRes.andEduc.(NCIRE) Dr.LillyBourguignonlab

attheSanFranciscoVAMedicalCenter

PhillipLarimer,MSTP,PhD2009CWRU3rdyearMedicalSchool

TimothyLehman,M.S.PfizerPharmaceuticals

JessicaLerchHaner,PhD2008PostdoctoralFellow,UniversityofMiami,FL,VanceLemmonLab

XiangLi,PhD2007PostdoctoralResearchFellow,E.KandelLab,ColumbiaUniversity

AllisonLimpert,PhD2005PostdoctoralFellow,VanderbiltUniversity,CarterLab


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AlumnioftheNeurosciencesProgram(continued)NamePresentPosition

StephenMaricich,MSTP,PhD1999AssistantProfessorPediatrics,UniversityHospitalsHealthSystems/CWRU

DougMcDonaldMSTP,Ph.D.1997AssistantProfessor,Allergy&Immunology,HarvardMedicalSchoolAssistantin

Medicine:ChildrensHospital,Boston

JenniferMcDonough,Ph.D.AssistantProfessor,Neurosciences,SchoolofBiomedicalSciences,KentStateUniv.,OakClinic

RobertMcKeon,Ph.D.AssistantProfessor,EmoryUniversity

KatyaMelnikMartinez,PhD2008PostdoctoralFellow,BiologicalSciences,UCSD,Dr.AmyPasquenelliLab

StaceyMembergMDPh.D.1995Pediatrician,PrivatePractice,Aetna,Medina,OH

HarryMenegay,II,Ph.D.2000Analy/ProgrammerIII,Ctr.forMemory&Aging,CWRU,UH

CatherineMeyer,M.S.2001Unknown

LouiseMilner,MD,Ph.D.Radiologist,ClevelandClinicFoundation

FredMoeslein,MSTP,PhD1999Resident,Radiology,CCF

RobertMohney,Ph.D.1998PostdoctoralFellow,LabofSignalTransduction,NationalInstituteofEnvironmentalHealth

Sciences

ShibaniMukerji,PhD2008CWRUMedicalSchool

MikeMyers,Ph.D.1996GroupLeader,ProteinNetworks,InternationalCtr.forGeneticEngineeringandBiotechnology(ICGEB),

Trieste,Italy

NenadIlic,M.S.2005Unknown

DianaOrentas,Ph.D.1997RegionalScientificAssociateDirector,CNS(Pharmaceuticals)

StephenOstrowski,MSTP,PhD2007CWRUMedicalSchool

DollyPadovaniClaudio,MSTP,PhD2006Residency,Ophthalmology,UniversityofMichigan

CarlosPena,Ph.D.DesignatedFederalOfficial,PAC,OfficeofScienceandHealthCoordination,OfficeoftheCommissioner,FDA

LuisPoloParada,Ph.D.1999AssistantProfessor,MedicalPharmacology&Physiology,Univ.ofMissouri,Columbia,MO

ToddPressler,PhD2006Postdoc,WadeRegehrLab,HarvardUniversity

LoriRaetzmann,MSTP,PhDAsst.Prof.,Molecular&IntegrativePhysiology&Neuroscience Univ.ofIllinois,UrbanaChampaign

VicRafuse,Ph.D.AssociateProfessor,DalhousieUniversity

ErinReedGeaghan,PhD2010PostdoctoralFellowCaseWesternReserveUniversity,StephenMaricichlab

AnnaRivkin,PhD2002ClinicalTrialsCoordinator,MerckPharmaceuticals

KarenRollins,M.S.StaffResearcher,MI

CatherineRottkamp,MSTP,PhD2007Resident,ChildrensHospital,Boston,MA

IvySamuels,PhD2008PostdocDr.NealPeacheyLabClevelandVAMed.Ctr.andDeptofOphthalmicResearch ColeEyeInst.

ClevelandClinicFoundation

AndrewSchaefer,Ph.D.Assoc.Res.Scientist,Mol.Cell&Dev.Biol.,Paul.ForscherLab,YaleUniversity

MichaelScott,PhD2005PostdoctoralFellow,J.ElmquistLab,UTSouthwestern

AnnetteShadiack,Ph.D.ExecutiveDirector,PreclinicalR&D,PalatinTechnologies,Inc.

MelissaShirley,M.S.1997Highschoolteacher,Olengtangy,OH

SarahShoemaker,PhD2006PostdoctoralRes.Assoc.,NeuroscienceCenter,SniderLab,Univ.NorthCarolina,ChapelHill,NC

DianeSnow,Ph.D.AssistantProfessor,DepartmentofSpinalCordandBrainInjuryResearch,UniversityofKentucky,Lexington

StaceyStephans,Ph.D.1997Sr.AssociateDirector,Programs,Neurology,EmoryUniversity

EstherStoeckli,Ph.D.AssociateProfessor,UniversityofZurich

YiSun,Ph.D.1997Asst.Prof.UCLA,Assoc.AcademicDir.UCLAInst.forStemCellBiol.&Medicine

KenSwanson,Ph.D.1998ResearchFellowinMedicineHarvardUniv.:BethIsraelDeaconessMed.Ctr. Hematology/Oncology

LoriTaylor,Ph.D.VicePresident,ElanPharmaceuticals

XiaoyingTang,M.S.2007ResearchAsst.,ClevelandClinicFoundation

VeronicaTom,PhD2004PostdoctoralResearcher,anatomyControl,DepartmentofNeurobiologyandAnatomy,JohnHoule

Lab,DrexelUniversityCollegeofMedicine,PA

HuiHsinTsai,PhD2002PostdoctoralFellow,DavidRowitchLab,Univ.California,SanFrancisco

MaryanneUsiak,Ph.D.2000Homemaker

NicholasVarvel,PhD2008GuestScientistattheHertieInstituteforClinicalBrainResearch,U.ofTubingen,Germany,Advisor:

MathiasJucker

DanielVogt,PhD2007PostdoctoralFellow,Neurosciences,PimplikarLab,ClevelandClinicFoundation

EricWong,Ph.D.AssistantProfessor,Biology,UniversityofLouisville

ChristiWylie,PhD2010PostdoctoralFellow,SanFrancisco

ZongqiXia,PhD,2003Fellow,Neurology,HarvardMedicalSchool

MianXie,PhD2007PostdoctoralFellow,AlanFadenLab,Neurosciences,GeorgetownUniversity

PinXu,PhD2007PostdoctoralFellow,GabrielCorfasLab,ChildrensHospital,Boston,MA

XiaohongXu,PhD2006Postdoc,N.ShahLab,UCSF

XiangDongYang,Ph.D.1997Cardiologist

XiuYang,PhD2008Resident,WashingtonUniversity

YuefangZhou,Ph.D.AssistantProfessor,DepartmentofNeurologyandPsychiatry,St.LouisUniversity,St.Louis,MO

LixinZhou,Ph.D.1997Sr.ResearchAssociate,Pediatrics,UniversityHospitalsHealthSystems,Cleveland,OH

Documents

2009-2010 Neurosciences Student Handbook Updated 1-19-10