BioMed Central Page 1 of 1 (page number not for citation purposes) Journal of Cardiovascular Magnetic Resonance Open Access Meeting abstract 2007 Blood oxygen level-dependent MRI in myocardium and skeletal muscle at 1.5 T and 3.0 T Peter Bernhardt*, Axel Bornstedt, Jochen Spiess, Vinzenz Hombach and Volker Rasche Address: University of Ulm, Ulm, Germany * Corresponding author Background Blood-oxygen level dependent (BOLD) cardiac magnetic resonance imaging (CMR) is a potential diagnostic tool to differentiate ischemic from non-ischemic myocardium. Methods T2* values of the myocardial and calf muscle were measured and compared between 1.5 T and 3 T to quantify the respective changes in the tissue T2* property, its depend- ency on the spatial resolution and to assess the sensitivity of the different field strength for hypoxia. T2* mapping of the calf muscle was performed in 15 volunteers before, during and after no-flow ischemia of the leg. In 23 healthy volunteers T2* maps of the myocardium were generated. Additionally, T2* was measured during adenosine infu- sion in eight volunteers. Results Mean myocardial T2* at 1.5 T was 47.96 ± 10.69 ms and at 3 T 20.44 ± 4.49 ms. After obstruction of the leg the T2* reduction of the calf at 1.5 T was 3.4% (p = 0.001) and 13.0% at 3 T (p < 0.0001). T2* relaxation increased signif- icantly during adenosine at 1.5 T and 3 T (p < 0.0001). Conclusion T2* quantification at 1.5 T and 3 T yields a linear relation- ship. No significant difference could be observed between breath hold and respiratory navigator gated techniques indicating the feasibility of T2* quantification at high spatial resolution. The T2* decrease during hypoxemia of the calf ant the increase during hyperemia of the myocardium indicate that our presented protocol could possibly be applied for evaluation of inducible myocardial ischemia. from 11 th Annual SCMR Scientific Sessions Los Angeles, CA, USA. 1–3 February 2008 Published: 22 October 2008 Journal of Cardiovascular Magnetic Resonance 2008, 10(Suppl 1):A276 doi:10.1186/1532-429X-10-S1-A276 <supplement> <title> Abstracts of the 11th Annual SCMR Scientific Sessions - 2008 </title> <note>Meeting abstracts – A single PDF containing all abstracts in this Supplement is available <a href="http://www.biomedcentral.com/content/files/pdf/1532-429X-10-s1-full.pdf">here</a>.</note> <url>http://www.biomedcentral.com/content/pdf/1532-429X-10-S1-info.pdf</url> </supplement> This abstract is available from: http://jcmr-online.com/content/10/S1/A276 © 2008 Bernhardt et al; licensee BioMed Central Ltd.

2007 Blood oxygen level-dependent MRI in myocardium and skeletal muscle at 1.5 T and 3.0 T

Download PDF Report

Upload
peter-bernhardt
View
218
Download
1

Embed Size (px)

Citation preview

Page 1: 2007 Blood oxygen level-dependent MRI in myocardium and skeletal muscle at 1.5 T and 3.0 T

BioMed Central

Page 1 of 1(page number not for citation purposes)

Journal of Cardiovascular Magnetic Resonance

Open AccessMeeting abstract2007 Blood oxygen level-dependent MRI in myocardium and skeletal muscle at 1.5 T and 3.0 TPeter Bernhardt*, Axel Bornstedt, Jochen Spiess, Vinzenz Hombach and Volker Rasche

Address: University of Ulm, Ulm, Germany

* Corresponding author

BackgroundBlood-oxygen level dependent (BOLD) cardiac magneticresonance imaging (CMR) is a potential diagnostic tool todifferentiate ischemic from non-ischemic myocardium.

MethodsT2* values of the myocardial and calf muscle were meas-ured and compared between 1.5 T and 3 T to quantify therespective changes in the tissue T2* property, its depend-ency on the spatial resolution and to assess the sensitivityof the different field strength for hypoxia. T2* mapping ofthe calf muscle was performed in 15 volunteers before,during and after no-flow ischemia of the leg. In 23 healthyvolunteers T2* maps of the myocardium were generated.Additionally, T2* was measured during adenosine infu-sion in eight volunteers.

ResultsMean myocardial T2* at 1.5 T was 47.96 ± 10.69 ms andat 3 T 20.44 ± 4.49 ms. After obstruction of the leg the T2*reduction of the calf at 1.5 T was 3.4% (p = 0.001) and13.0% at 3 T (p < 0.0001). T2* relaxation increased signif-icantly during adenosine at 1.5 T and 3 T (p < 0.0001).

ConclusionT2* quantification at 1.5 T and 3 T yields a linear relation-ship. No significant difference could be observed betweenbreath hold and respiratory navigator gated techniquesindicating the feasibility of T2* quantification at high spa-tial resolution. The T2* decrease during hypoxemia of the

calf ant the increase during hyperemia of the myocardiumindicate that our presented protocol could possibly beapplied for evaluation of inducible myocardial ischemia.

from 11th Annual SCMR Scientific SessionsLos Angeles, CA, USA. 1–3 February 2008

Published: 22 October 2008

Journal of Cardiovascular Magnetic Resonance 2008, 10(Suppl 1):A276 doi:10.1186/1532-429X-10-S1-A276

<supplement> <title> Abstracts of the 11th Annual SCMR Scientific Sessions - 2008 </title> <note>Meeting abstracts – A single PDF containing all abstracts in this Supplement is available <a href="http://www.biomedcentral.com/content/files/pdf/1532-429X-10-s1-full.pdf">here</a>.</note> <url>http://www.biomedcentral.com/content/pdf/1532-429X-10-S1-info.pdf</url> </supplement>

This abstract is available from: http://jcmr-online.com/content/10/S1/A276

http://jcmr-online.com/content/10/S1/A276

http://www.biomedcentral.com/

http://www.biomedcentral.com/info/about/charter/