1st Pharmaceutical Calculation

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College!of!Pharmacy!Department!of!Pharmaceutics!

First!Stage:!!!&

!Ministry!of!Higher!Education!And!Scientific!Research!University!of!Basra!!!

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Course'Syllabus'

'Name!of!the!First!Teacher!of!the!Course:!Dr!Mohammed!Sabbar!

Academic!Rank:!Lecturer!

Degree:!PhD!in!Pharmaceutics!!

Email:[email protected]!

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Name!of!the!Second!Teacher!of!the!Course:!Dr!Mohammed!Sattar!


Degree:!PhD!in!Pharmaceutics!


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Name!of!the!Third!Teacher!of!the!Course:!Ahmed!Abdulkarem!

Academic!Rank:!Assistant!Lecturer!

Degree:!MSc!in!Pharmaceutics!


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Pharmaceutical!Calculation!Course&Title&

Semester!Academic&System&

It!involves!computation!of!pharmaceutical!ingredients,!dosage!forms,!pharmaceutical!formulations!of!extemporaneous!compounding,!and!biological!parameters!of!drug!substances.!!The!course!teaches!calculations!for!dilution!and!concentration!of!different!types!of!liquids!and!those!involved!in!preparing!isotonic!solutions,!electrolyte!solutions!and!intravenous!admixtures.!!!

Course&Objective&

Pharmaceutical!Calculation!by!Stoklosa;!Latest!edition.!Textbooks&

Pharmaceutical!calculations,!by!Ansel!Reference&Books&

End!Semester!Examination!Project!Quizzes!Laboratory!

Work!

Theoretical!Content!Exam!

Course&Assessment&for&Semester&System&

(100%)& 50!T!T!25!25!

The!module!is!given!on!the!second!semester!for!the!first!year!student!in!two!hours!of!theory!and!two!hours!practical!laboratory!work!per!week!

Additional&Information&

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Weekly&Schedule&

Notes!Laboratory!Work!Theoretical!Content!Week!

!Demonstration!of!different!glass!wares!and!equipments!used!in!the!field!of!pharmacy.!

Dilution!and!concentration!of!pharmaceutical!preparations.!(five!weeks)!

1!

!Pharmaceutical!measurements.!!2!

!Volume!measurements.!!3!

!Preparation!of!aromatic!waters.!(Two!weeks).!!4!

!!!5!

!Preparation!of!simple!solutions.!

Isotonic!solutions.!(Three!weeks)!6!

!Reducing!and!enlarging!prescription!contents.!(Two!weeks).!

!7!

!!!8!

!Percentages!in!calculating!prescription!content.!(Two!weeks).!

Electrolyte!solutions!(milliequivalents,!millimoles!and!milliosmoles).!(Three!weeks)!

9!

!!!10!

!Percentages!in!calculating!prescription!contents.!(Two!weeks)!

!11!

!!Constituted!solutions,!I.V!admixtures!and!flow!rate!calculations.!(4!weeks).!

12!

!Stock!solutions!and!dilution!technique!during!dispensing!technique.!(Three!weeks)!

!13!

!!!14!

!!!15!!

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First!Stage:!!!&


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Course'Syllabus'

'Name!of!the!First!Teacher!of!the!Course:!Dr!Mohammed!Sabbar!




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Principles!of!Pharmacy!Practice!Course&Title&


Involves!brief!information!about!old!pharmacy.!!It!teaches!kinds!of!numbers,!abbreviations!that!are!commonly!used!in!prescriptions!and!their!meanings.!!In!this!course!the!students!will!understand!the!components!of!typical!prescription,!the!different!unit!systems!and!the!relation!between!these!systems.!!Students!will!also!be!familiar!with!the!methods!and!tools!of!measuring!weights!and!volumes,!and!how!to!calculate!doses!on!different!bases!and!know!how!to!reduce!or!enlarge!formulas;!they!will!be!able!to!describe!values!in!percentage!and!ratio!strength.!

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Course&Objective&

Pharmaceutical!Calculation!by!Stoklosa;!Latest!edition.!Textbooks&

Pharmaceutical!calculations!,!by!Ansel!!Reference&Books&

End!Semester!Examination!Project!Quizzes!

Laboratory!Work!



(100%)& 70!D!5!D!25!

The!module!is!given!on!the!first!semester!for!the!first!year!student!as!two!hours!of!theoretical!lectures!per!week!


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Weekly&Schedule&

!Notes!Theoretical!Content!Week!

4h!Some!fundamentals!of!measurements!and!calculation.!1!&!2!

4!h!Interpretation!of!prescription!or!medication!orders.!3!&!4!

4!h!The!metric!system!5!&!6!

4!h!Calculation!of!doses.!7!&!8!

4!h!Reducing!and!enlarging!formulas.!9!&!10!

4!h!Density,!specific!gravity!and!specific!volume.!

11!&!12!

6!h!Percentage!and!ratio!strength!calculation.!13^15!

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Second!Stage:!!!'


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Course'Syllabus'

'Name!of!the!First!Teacher!of!the!Course:!Dr!Mohammed!Sattar!




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Name!of!the!Second!Teacher!of!the!Course:!Dr!Ahmed!Najim!




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Name!of!the!Third!Teacher!of!the!Course:!Assistant!Lecturer!Ahmed!Sami!


Degree:!Msc!in!Pharmaceutics!


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Physical!Pharmacy!I!Course'Title'

Semester!Academic'System'

To!understand!the!application!of!quantitative!and!theoretical!principles!of!the!physical!characters!of!matter!in!the!practice!of!pharmacy.!!It!aids!the!pharmacists!in!their!attempt!to!predict!the!solubility,!compatibility!and!biological!activity!of!drug!products.!!As!a!result!of!this!knowledge!it!will!help!in!the!development!of!new!drugs!and!dosage!forms!as!well!as!in!improvement!of!various!modes!of!administration.!!

Course'Objective'

!Physical)Pharmacy)by)Alfred)Martin)et)al;)(Latest)edition).!Textbooks'

Physicochemical)Principles)of)Pharmacy,)by)Alexander)T)

Florence!Reference'Books'


Work!


Course'Assessment'for'Semester'System'

(100%)' 50!A!A!25!25!

The!module!is!given!on!the!first!semester!for!the!second!year!

student!in!three!hours!of!theory!and!two!hours!practical!

laboratory!work!per!week!

Additional'Information'

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Weekly'Schedule'


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Expression!of!concentrations!in!pharmaceutical!preparations!

States!of!matter,!binding!forces!between!molecules,!gases,!liquids,!solid!and!crystalline!matters.!

1!

!Two!component!systems!containing!liquid!phases.!(2!weeks)!

Phase!equilibria!and!phase!rule.!2!

!!Thermal!analysis.!3!

!Three!component!systems.!(2!weeks)!

Thermodynamics,!first!law.!4!

!!thermochemistry,!

second!law,!third!law.!!

5!

!Tie!linear!for!three!component!systems.!(2!weeks)!

Free!energy!function!and!applications.!

6!

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!Solutions!of!nonZelectrolytes,!properties,!ideal!and!real!solution.!

7!

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Partition!coefficient:!Measurements!and!evaluation.!(2!weeks)!

Colligative!properties,!molecular!weight!determination.!

8!

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Solution!of!electrolytes,!properties,!Arrhenius!theory!of!dissociation,!theory!of!strong!electrolytes.!!

9!

!Solubility!methods.!(2!weeks)!

Ionic!strength,!DebyeZHuchle!theory,!coefficients!for!expressing!colligative!

10!

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properties.!

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Ionic!equilibria,!modern!theories!of!acids,!bases!and!salts,!acidZbase!equilibria.!!

11!

!Buffer!solutions.!(2!weeks)!

Calculation!of!pH,!acidity!constants.!!12!

!!The!effect!of!ionic!strength!and!free!energy!

13!

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Determination!of!solubility!product!constant!of!slightly!

soluble!salts.!(2!weeks)!

Buffered!and!isotonic!solutions:!Buffer!equation;!buffer!capacity;!!

14!

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methods!of!adjusting!tonicity!and!pH;!buffer!and!biological!system.!

15!

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Second!Stage:!!!'


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Course'Syllabus'





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Name!of!the!Second!Teacher!of!the!Course:!Dr!Ahmed!Najim!




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Name!of!the!Third!Teacher!of!the!Course:!Assistant!Lecturer!Ahmed!Sami!


Degree:!Msc!in!Pharmaceutics!


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Physical!Pharmacy!II!Course'Title'


To!understand!the!application!of!quantitative!and!theoretical!principles!of!the!physical!characters!of!matter!in!the!practice!of!pharmacy.!!It!aids!the!pharmacists!in!their!attempt!to!predict!the!solubility,!compatibility!and!biological!activity!of!drug!products.!!As!a!result!of!this!knowledge!it!will!help!in!the!development!of!new!drugs!and!dosage!forms!as!well!as!in!improvement!of!various!modes!of!administration.!!

Course'Objective'

!Physical)Pharmacy)by)Alfred)Martin)et)al;)(Latest)edition).!Textbooks'

Physicochemical)Principles)of)Pharmacy,)by)Alexander)T)

Florence!Reference'Books'


Work!



(100%)' 50!A!A!25!25!

The!module!is!given!on!the!second!semester!for!the!second!

year!student!in!three!hours!of!theory!and!two!hours!practical!

laboratory!work!per!week!


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Weekly'Schedule'


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Solubilization!of!components!of!pharmaceutical!preparations.!(2!weeks)!

Solubility!and!distribution!phenomena,!solventUsolute!interactions,!solubility!of!gases!in!liquids.!

1!

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!Solubility!of!liquids!in!liquids,!solubility!of!nonUionic!solids!in!liquids.!

2!

!Solubilization!of!Aspirin.!(2!weeks)!

Distribution!of!solutes!between!immiscible!solvents.!

3!

!!Complexation,!

classification!of!complexes.!

4!

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Review!and!tutorial!Methods!of!analysis,!thermodynamic!treatment!of!stability!constants.!

5!

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Rate!kinetic:!Application!in!stability!of!pharmaceutical!stability.!!

Kinetics,!rate!and!orders!of!reactions.!6!

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Aspirin!stability!Influence!of!temperature!and!other!factors!on!reactions!rate.!

7!

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Review!and!tutorial!Decomposition!of!medicinal!agents!and!accelerated!stability!analysis.!

8!

!Surface!tension:!measurements!and!calculations.!(2!weeks)!

Interfacial!phenomena,!liquid!interfaces,!surface!free!energy,!measurement!of!interfacial!tension,!

9!

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spreading!coefficient,!surface!active!agents!and!wetting!phenomena.!

!Effect!of!Salt!on!the!Solubility!of!Nonelectrolyte!

Colloids,!dispersed!system!and!its!pharmaceutical!application.!

10!

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Determination!of!the!Critical!Micelle!Concentration!of!Surface!Active!Material!!!

Types!of!colloidal!systems,!kinetic!properties,!diffusion,!zeta!potential,!solubilization.!

11!

!Review!and!tutorial!

Micrometrics,!particle!size,!methods!of!determining!particle!size,!particle!shape!and!surface!area,!porosity,!density.!

12!

!Viscosity:!Measurements!and!calculation.!(2!weeks)!

Rheology,!Newtonian!systems,!thixotropy!measurement.!!

13!

!!Negative!thixotropy,!determination!of!thixotropy.!

14!

!Adsorption!isotherm.!!!!

Polymer!science,!definitions!pharmaceutical!applications,!molecular!weight!averages.!

15!

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Third!Stage:!!!&


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Course'Syllabus'





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Name!of!the!Second!Teacher!of!the!Course:!Nawar!Adai!




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Name!of!the!Third!Teacher!of!the!Course:!

Academic!Rank:!

Degree:!

Email:!

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Pharmaceutical!Technology!I!Course&Title&


To!teach!theoretical!bases!for!the!technology!of!preparing!different!dosage!forms!with!respect!to!their!raw!materials,!compositions,!methods!of!preparation,!stability,!storage!and!uses.!!!

Course&Objective&

Pharmaceutical,Dosage,forms,and,Drug,Delivery,Systems,By,Haward,A.,Ansel;,latest,edition..!

Textbooks&

Sprowel's,American,Pharmacy;!Latest,edition!Reference&Books&

End!Semester!Examination!

Project!Quizzes!Laboratory!

Work!



(100%)& 50!D!D!25!25!

The!module!is!given!on!the!first!semester!for!the!third!year!student!in!three!hours!of!theory!and!two!hours!practical!laboratory!work!per!week!


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Weekly&Schedule&


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Solutions!(Into!body!cavity,!oral!and!external!use).!Two!weeks!

Dispersed!systems:!their!classification;!comparisons!between!different!systems.!

1!

!!Solutions!and!types!of!solutions.!2!

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Syrups:!Preparation!techniques!and!quality!evaluation.!Two!weeks!

Solubility:!Factors!affecting!solubility;!expression!of!dissolution;!dissolution!rate!versus!solubility;!preparation!of!solutions!containing!nonWvolatile!materials.!

3!

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!Official!solutions;!classification!of!official!solutions;!preparation!and!uses.!

4!

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Review!and!tutorial!Aqueous!solutions!containing!aromatic!principles;!aromatic!waters;!methods!of!preparations;!stability.!

5!

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Elixirs:!Preparation!techniques!and!quality!evaluation.!Two!weeks!

Syrups:!sugar!based!syrups;!artificial!and!sorbitol!based!syrups;!stability!of!syrups.!

6!

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!Definition!and!methods!of!clarification;!filter!aids!in!clarification.!!

7!

!Spirits:!Preparation!techniques!and!quality!

Preparation!of!solutions!using!

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evaluation.!!Two!weeks!mixed!solvent!systems;!spirits,!and!elixirs.!

!!Extraction;!maceration!and!percolation.!!

9!

!Review!and!tutorial!Tinctures;!fluid!extracts;.!10!

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Suspensions:!Preparation!techniques!and!quality!evaluation.!!Three!weeks!

Extracts!of!resins!and!oleoresins.!

11!

!!Colloidal!dispersions;!lyophilic;!lyophobic.!

12!

!!Colloidal!dispersions;!lyophilic;!lyophobic.!13!

!Dispersion!of!oils!in!inhalations.!Two!weeks!

Coarse!dispersion;!suspensions.!14!

!!Coarse!dispersion;!suspensions.!15!

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Third!Stage:!!!&


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Course'Syllabus'





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Name!of!the!Second!Teacher!of!the!Course:!Nawar!Adai!




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Academic!Rank:!

Degree:!

Email:!

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Pharmaceutical!Technology!II!Course&Title&


To!teach!theoretical!bases!for!the!technology!of!preparing!different!dosage!forms!with!respect!to!their!raw!materials,!compositions,!methods!of!preparation,!stability,!storage!and!uses;!in!addition!to!define!and!characterize!the!possible!incompatibilities!that!may!occur!in!dosage!forms.!!!!!

Course&Objective&

Pharmaceutical,Dosage,forms,and,Drug,Delivery,Systems,By,Haward,A.,Ansel;,latest,edition..!

Textbooks&

Sprowel's,American,Pharmacy;!Latest,edition!Reference&Books&



Work!



(100%)& 50!D!D!25!25!

The!module!is!given!on!the!second!semester!for!the!third!year!student!in!three!hours!of!theory!and!two!hours!practical!laboratory!work!per!week!


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Weekly&Schedule&


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Emulsions:!Preparation!techniques!and!quality!evaluation.!Two!weeks!

Emulsions;!purpose!of!emulsification;!methods!of!emulsification;!emulsifying!agents;!HLB!system;!stability!of!emulsions.!Three!weeks.!

1!

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Suppositories:!Preparation!techniques!and!quality!evaluation.!Two!weeks!

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3!

!!Lotions;!liniments!

and!collodions.!Two!weeks!

4!

!Review!and!tutorial!!5!

!Powders:!Preparation!techniques!and!quality!evaluation.!!Two!weeks.!

Suppositories.!Three!weeks!6!

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!Capsules:!Preparation!techniques!and!quality!evaluation.!!Two!weeks!

!8!

!!Powdered!dosage!forms.!Three!weeks.!9!


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Semisolid!dosage!forms:!Preparation!techniques!and!quality!evaluation.!!!4!weeks.!

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11!

!!Semisolid!dosage!forms.!Three!weeks.!12!

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!Review!and!tutorial!Incompatibilities!in!pharmaceutical!dosage!forms.!

15!

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Fourth!Stage:!!!'


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Course'Syllabus'

'Name!of!the!First!Teacher!of!the!Course:!Dr!Audy!Sajad!



Email:!!

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Biopharmacy!Course'Title'


The!coarse!deals!with!the!physical!and!chemical!properties!of!drug!substance,!dosage!form!and!the!biological!effectiveness!of!the!drug!or!drug!product!upon!administration,!including!drug!availability!in!the!human!or!animal!body!from!a!given!dosage!form.!!The!pharmacokinetic!part!of!the!coarse!deals!with!the!timeMcoarse!of!the!drug!in!the!biological!system,!and!quantification!of!drug!concentration!pattern!in!normal!subjects!and!in!certain!disease!states.!

Course'Objective'

Shargel(L,(Yu(AB,((Eds.),(Applied(Biopharmaceutics(and(

Pharmacokinetics;(Latest(edition.!Textbooks'

Aulton(Biopharmaceutics.!Reference'Books'


Work!



(100%)' 50!M!M!25!25!

The!module!is!given!on!the!first!semester!for!the!fourth!year!student!in!two!hours!of!theory!and!two!hours!practical!laboratory!work!per!week!


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Weekly'Schedule'


!Preparation!of!calibration!curve!of!salicylic!acid.!

Introduction!to!biopharmaceutics.!1!

!In#vitro!evaluation!of!bulk!laxative.!

Biopharmaceutic!aspects!of!products!!2!

!In#vitro!evaluation!of!antacids.!!

Drug!absorption;!mechanisms!of!absorption.!

3!

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Dissolution!of!tablets.!(two!weeks)!

Physicochemical!factors;!dissolution!rate;!effects!of!excipients;!type!of!dosage!forms.!

4!

!!One!compartment!open!model.!5!

!Review!and!tutorial!Multicompartment!models.!6!

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Determination!of!pharmacokinetic!parameters!from!CPMtime!by!residual!method.!(Two!weeks)!

Pharmacokinetics!of!drug!absorption.!

7!

!!Bioavailability!and!bioequivalence.!8!

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Determination!of!pharmacokinetic!parameters!from!CPMtime!by!trapezoidal!method.!(Two!weeks)!

Clearance!of!drugs!from!the!biological!systems.!9!

!!Hepatic!elimination!of!drugs.!10!

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Determination!of!pharmacokinetic!parameters!from!urine!excretion!samples.!(Two!weeks)!

Protein!binding!of!drugs.!

11!

!!Intravenous!infusion!12!

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!Hydrolysis!of!!!aspirin!in!buffer!pH!6.8.!(Two!weeks)!

Multiple!dosage!regimens.!13!

!!NonMlinear!pharmacokinetics.!14!

!Review!and!tutorial!Dosage!adjustment!in!renal!diseases.!15!

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Fourth!Stage:!!!'


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Course'Syllabus'

'Name!of!the!First!Teacher!of!the!Course:!Dr!Ahmed!Najim!




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Name!of!the!Third!Teacher!of!the!Course:!Malath!Alshawi!


Degree:!MSC!in!Industrial!Pharmacy!


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Industrial!Pharmacy!I!Course'Title'


The!subject!aim!to!teach!pharmacy!students!the!steps!and!lines!upon!which!the!preformulation!processing!of!pharmaceutical!dosage!forms.!This!fundamental!coarse!provide!the!required!principles!to!integrate!knowledge!of!Pharmaceutical!Technology!in!preformulation!of!perfect!dosage!form.!It!includes!milling,!mixing,!drying!and!filtration,!besides!sterilization!to!achieve!a!proper!processing!of!dosage!forms.!

Course'Objective'

The$Theory$and$Practice$of$Industrial$Pharmacy$by$Leon$Lachman$et$al.(Latest$edition).!

Textbooks'

Aulton$Pharmaceutics!Reference'Books'



Work!



(100%)' 50!E!E!25!25!

The!module!is!given!on!the!second!semester!for!the!fourth!year!student!in!three!hours!of!theory!and!two!hours!practical!laboratory!work!per!week!


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Weekly'Schedule'


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Introduction!!!in!industrial!pharmacy!and!preRformulation.!

Principles!of!pharmaceutical!processing;!mixing;!fluid!mixing;!flow!characteristics;!mechanisms!of!mixing;!mixing!equipments;!batch!and!continuous!mixing;!mixer!selection;!solid!mixing!theory!and!particulate!solid!variables;!forces!and!mechanisms.!Three!weeks!

1!

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Effervescent!granules:!Preparation!and!characterization.!

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2!

!Flow!properties!and!rheology!of!granules.!

!3!

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Tablet!dosage!form:!Preparation!and!characterization.!

Milling;!pharmaceutical!application;!size!measurement!methods;!theory!and!energy!of!commenution;!types!of!mills;!factors!influencing!milling;!selection!of!mill!techniques;!specialized!drying!methods.!Three!weeks!

4!


!Evaluation!of!tablets.!

!6!

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Preparation!of!children!aspirin!by!wet!granulation!method.!

Drying:!definition;!purpose;!humidity!measurement;!theory!of!drying;!drying!of!solids,!and!classification!of!dryer;!specialized!drying!methods.!Two!weeks!

7!

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Sustained!release!dosage!forms:!Preparation!and!characterization.!

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8!

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Coating!techniques!of!tablets.!!!

Clarification!and!filtration:!Theory;!filter!media;!filter!aids;!selection!of!drying!method;!nonRsterile!and!sterile!operations;!integrity!testing;!equipments!and!systems!(commercial!and!laboratory).!Two!weeks!

9!


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Introduction!!!in!industrial!pharmacy!and!preRformulation.!

Sterilization;!validation!of!methods;!microbial!death!kinetics;!methods!of!sterilization!(thermal!and!nonRthermal);!mechanisms;!evaluation.!Two!weeks!

11!

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Effervescent!granules:!Preparation!and!characterization.!

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12!

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Flow!properties!and!rheology!of!granules.!

Pharmaceutical!dosage!form!design;!preRformulation;!preliminary!evaluation;!bulk!characterization;!solubility!and!stability!analysis.!

13!

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Tablet!dosage!form:!Preparation!and!characterization.!

Pharmaceutical!dosage!forms;!sterile!products;!development;!formulation;!production;!processing;!quality!control.!Two!weeks!

14!

!Review!and!tutorial!!15!!

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Fifth!Stage:!!!&


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Course'Syllabus'

'Name!of!the!First!Teacher!of!the!Course:!Dr!Ahmed!Najim!




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Name!of!the!Third!Teacher!of!the!Course:!Malath!Alshawi!


Degree:!MSC!in!Industrial!Pharmacy!


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Industrial!Pharmacy!II!Course&Title&


The!coarse!enable!technical!setup!for!coordination!of!standards!for!formulation!of!typical!dosage!forms!and!the!principles!needed!to!learn!mass!production!of!different!pharmaceutical!dosage!forms.!The!syllabus!includes!different!dosage!forms!like!tablets,!capsules,!aerosols,!emulsion,!etc,!besides!the!advanced!techniques!like!enteric!coating!and!microNencapsulation.!!

Course&Objective&

The$Theory$and$Practice$of$Industrial$Pharmacy$by$Leon$Lachman$et$al.(Latest$edition).!

Textbooks&

Aulton$Pharmaceutics!Reference&Books&



Work!



(100%)& 50!E!E!25!25!

The!module!is!given!on!the!first!semester!for!the!fifth!year!student!in!three!hours!of!theory!and!two!hours!practical!laboratory!work!per!week!


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Weekly&Schedule&


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Direct!compression!method!for!preparation!of!tablets.!Two!weeks!

Pharmaceutical!dosage!forms:!Tablets;!role!in!therapy;!advantages!and!disadvantages;!formulation;!properties;!evaluation;!machines!used!in!tableting;!quality!control;!problems;!granulation,!and!methods!of!production;!excipients,!and!types!of!tablets.!Three!weeks.!

1!

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Wet!granulation!method!for!preparation!of!tablets.!Two!weeks!

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3!

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!Tablet!coating;!principles;!properties;!equipments;!processing;!types!of!coating!(sugar!and!film);!quality!control,!and!problems.!

4!

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Dry!granulation!method!for!preparation!of!tablets.!Two!weeks.!

Capsules:!Hard!gelatin!capsules;!materials;!production;!filling!equipments;!formulation;!special!techniques.!!

5!

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!Soft!gelatin!capsules:!Manufacturing!methods;!nature!of!capsule!shell!and!content;!processing!and!control;!stability.!

6!

!Review!and!tutorial!MicroNencapsulation;!core!and!

coating!materials;!stability;!equipments!and!methodology.!

7!

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Evaluation!of!tablets.!Two!weeks.!

Modified!(sustained!release)!dosage!forms;!theory!and!concepts;!evaluation!and!testing;!formulation.!

8!

!!Liquids:!Formulation;!stability!and!equipments.!9!

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Capsules!dosage!form:!Preparation!and!evaluation.!Three!weeks!

Suspensions:!Theory;!formulation!and!evaluation.!

10!

!!Emulsions:!Theory!and!

application;!types;!formulation;!equipments!and!quality!control.!

11!

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!Semisolids:!Percutaneouse!absorption;!formulation;!types!of!bases!(vehicles)!preservation;!processing!and!evaluation.!!

12!

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Parenteral!dosage!forms.!Two!weeks.!

Suppositories:!Rectal!absorption;!uses!of!suppositories;!types!of!bases;!manufacturing!processes;!problems!and!evaluation.!

13!

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!Pharmaceutical!aerosols:!Propellants;!containers;!formulation;!types!and!selection!of!components;!stability;!manufacturing;!quality!control!and!testing.!Two!weeks!

14!

!Review!and!tutorial!!15!!

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Fifth!Stage:!!!&


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Course'Syllabus'





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Name!of!the!Second!Teacher!of!the!Course:!Dr!Audy!Sajad!


Degree:!PhD!in!Pharmaceutic!

Email:!

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Name!of!the!Third!Teacher!of!the!Course:!Abdulrazaq!Hameed!


Degree:!MSc!in!Drug!delivery!


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Dosage!form!design!Course&Title&


This!course!enables!students!to!understand!the!principles!and!factors!that!influence!design!of!dosage!forms;!and!the!applications!of!these!principles!in!the!practice!of!pharmaceutical!industry.!

Course&Objective&

Pharmaceutical,Dosage,Forms,and,Drug,Delivery,Systems,by,Haward,A.,,Ansel;,Latest,edition!!Textbooks&

Pharmaceutics,,,by,Aulton!!Reference&Books&


Work!



(100%)& 70!E!5!E!25!

The!module!is!given!on!the!second!semester!for!the!fifth!year!student!in!two!hours!of!theory!per!week!


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Weekly&Schedule&

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Notes!Theoretical!Content!Week!

1!Pharmaceutical!consideration:!The!need!for!the!dosage!form.!!!!1!

3!!General!consideration!for!the!dosage!form.!!1!&!2!

2!!PreVformulation;!physical!description,!microscopic!examination.!3!

2!!Melting!point;!phase!rule;!particle!size;!polymorphism;!solubility.!4!

2!!Permeability;!pH;!partition!coefficient;!pka;!stability;!kinetics;!shelf!life.!!5!

2!!Rate!reaction;!enhancing!stability.!6!

2!

!Formulation!consideration:!Excipients;!definition!and!types;!appearance;!palatability;!flavoring.!

7!

2!Sweetening;!coloring!pharmaceuticals;!preservatives;!sterilization;!preservatives!selection.!

8!

4!Biopharmaceutical!considerations:!Principle!of!drug!absorption;!dissolution!of!the!drugs.!!9!&10!

3!Bioavailability!and!bioequivalancy;!FDA!requirements.!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!11!&!12!

3!Assessment!of!bioavailability;!bioequivalence!among!drug!products.!12!&!13!

4!Pharmacokinetic!principles:!!HalfVlife;!clearance;!dosage!regimen!!!considerations.!14!&!15!

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First!Stage:!!!&


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Course'Syllabus'

'Name!of!the!First!Teacher!of!the!Course:!Dr.!Ahmed!Najim!Abood!




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Name!of!the!Second!Teacher!of!the!Course:!

Academic!Rank:!

Degree:!

Email:!

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Academic!Rank:!

Degree:!

Email:!

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Pharmaceutical!Biotechnology!Course&Title&


This!course!enables!students!to!understand!the!general!introduction,!formulation!factors,!and!the!biopharmaceutical!considerations!that!influence!the!biotechnological!products.!

Course&Objective&

!!Pharmaceutical!biotechnology!(J!.!A!.!Crommelin!,!Robert!D.!

Syinder)!

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Textbooks&

!!Pharmaceutical!Dosage!Forms!and!Drug!Delivery!Systems!

by!Haward!A.!!Ansel;!Latest!edition!!Reference&Books&



Work!



(100%)! 70!#!5!#!25!

The!module!is!given!on!the!second!semester!for!the!fifth!year!student!in!one!hour!of!theory!per!week!


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Weekly&Schedule&

Notes!Theoretical!Content!Week!

!Biotechnology!!!!Y!introduction!1!

!Pre!–formulation!considerations!of!biotechnology!product!!

2!

!Microbial!considerations!3!

!Formulation!materials!and!considerations!!!4Y6!

!biopharmaceutical!considerations!7Y11!

!Pharmacokinetics!of!peptides!and!proteins!!!!

12Y15!

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Documents

1st Pharmaceutical Calculation