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1982-1991 = 2002-2012 = 1992-2001 = AED=antiepileptic drug. I am 6 3% 6 4% 6 1% Few can evade me I’m still going strong It’s time for the world to know the truth about seizures Poor response to AEDs? There’s plenty of that. Yet many of my captives continue to be prescribed the same medications, year after year, without switching—even though they are the very medications that fail to stop me completely. 3 • 1.8 million of your adult patients who are still seizing are my captives 1 • According to the CDC, nearly 60% of your adult patients with epilepsy continue to have seizures despite the use of AEDs 1 • With each failed AED treatment regimen, my grip on each captive grows tighter, as their likelihood of ever achieving zero seizures slips further and further away 2 • More than a dozen AEDs have tried to challenge me over the past 2 decades, but what difference has it made? 2 • Seizure freedom rates today are nearly identical to what they were in the 1980s 2 • These statistics may alarm you. The percentage of patients who achieved 1 year of seizure freedom was 2 :

1982-1991 = 1992-2001 = 2002-2012 = 63% 4% 6 1% · SUDEP=sudden unexpected death in epilepsy. References: 1. Tian N, Boring M, Kobau R, Zack MM, Croft JB. Active epilepsy and seizure

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Page 1: 1982-1991 = 1992-2001 = 2002-2012 = 63% 4% 6 1% · SUDEP=sudden unexpected death in epilepsy. References: 1. Tian N, Boring M, Kobau R, Zack MM, Croft JB. Active epilepsy and seizure

1982-1991 = 2002-2012 =1992-2001 =

AED=antiepileptic drug.

I am

63% 64% 61%

Few can evade me

I’m still going strong

It’s time for the world to know the truth about

seizures

Poor response to AEDs? There’s plenty of that. Yet many of my captives continue to be prescribed the same medications, year after year, without switching—even though they are the very medications that fail to stop me completely.3

• 1.8 million of your adult patients who are still seizing are my captives1

• According to the CDC, nearly 60% of your adult patients with epilepsy continue to have seizures despite the use of AEDs1

• With each failed AED treatment regimen, my grip on each captive grows tighter, as their likelihood of ever achieving zero seizures slips further and further away2

• More than a dozen AEDs have tried to challenge me over the past 2 decades, but what difference has it made?2

• Seizure freedom rates today are nearly identical to what they were in the 1980s2

• These statistics may alarm you. The percentage of patients who achieved 1 year of seizure freedom was2:

Page 2: 1982-1991 = 1992-2001 = 2002-2012 = 63% 4% 6 1% · SUDEP=sudden unexpected death in epilepsy. References: 1. Tian N, Boring M, Kobau R, Zack MM, Croft JB. Active epilepsy and seizure

© 2019 SK Life Science, Inc., a subsidiary of SK Biopharmaceuticals Co., Ltd. PM-US-SKLSI-0099 03/19

SUDEP=sudden unexpected death in epilepsy.

References: 1. Tian N, Boring M, Kobau R, Zack MM, Croft JB. Active epilepsy and seizure control in adults—United States, 2013 and 2015. MMWR Morb Mortal Wkly Rep. 2018;67(15):437-442. 2. Chen Z, Brodie MJ, Liew D, Kwan P. Treatment outcomes in patients with newly diagnosed epilepsy treated with established new antiepileptic drugs: a 30-year longitudinal cohort study. JAMA Neurol. 2018;75(3):279-286. 3. Data on file. IQVIA. 2018. 4. Josephson CB, Patten SB, Bulloch A, et al. The impact of seizures on epilepsy outcomes: a national, community-based survey. Epilepsia. 2017:58(5):764–771. 5. Nilsson L, Farahmand BY, Persson PG, Thiblin I, Tomson T. Risk factors for sudden unexpected death in epilepsy: a case-control study. Lancet. 1999;353(9156):888-893.

*Compared with those who have managed to live free from seizures for 5 years.

6x

3x

4x

4.5x

2x

3x

4x

2x

Once I attack, my captives'

lives may fall to pieces

4

Get closer to the truth at

Brave enough to find out more?

EpilepsyCaptives.com.

Just one episode ina 5-year span makes them*:

more likely to have depression

more likely to have poor health

more likely to require daily informal assistance

more likely to be prevented from driving

more likely to have limitations in education

more likely to have limitations in employment

more likely to have limitations in at least 1 usual activity

more likely to experience stigma

I can end so muc

h more than

their independen

ce. Having

seizures puts th

em at a 23

times greater ri

sk of SUDEP

compared with th

ose who are

seizure free.

5