Venue: Universitat Politècnica de ValènciaEdificio RectoradoCamí de Vera s/n, Valencia

16th ASEICA INTERNATIONAL

CONGRESSValencia, 6th - 7th - 8th November 2018

Organized by:

www.aseica.es

PRELIMINARY PROGRAM

SCIENTIFIC COORDINATORS

Dr. Carlos CampsDr. Arkaitz Carracedo

Dr. Héctor PeinadoDra. Angélica Figueroa

Dra. Noemí ReguartDra. Gema Moreno

SCIENTIFIC COMMITTEE

Dr. Carlos CampsDr. Xosé R. Bustelo

Dra. Noemí ReguartDr. Arkaitz Carracedo

Dr. Jesús ParamioDra. Angélica Figueroa

Dra. Gema MorenoDr. Héctor Peinado

Dra. María S. SoengasDr. José PalaciosDr. Rafael López

HONOR COMMITTEE

Hble. Sra. Ana Barceló, Consellera de Sanidad Universal

y Salud Pública de Valencia

Don Francisco J. Mora, Rector Magnífico de la Universidad

Politécnica de Valencia

Doña Mª Vicenta Mestre, Rectora Magnífica de

la Universidad de Valencia

Doña Raquel Yotti, Directora Instituto de Salud Carlos III

LOCAL COMMITTEE

Dra. Eloisa JantusDr. Rafael Sirera

Dra. Deborah BurksDra. Sílvia Calabuig-Fariñas

08:00 - 10:35 STUDENT WORKSHOP: SKILLS IN INVESTIGATION

08:00 - 08:05 Welcome and Introduction Dra. Eloísa Jantus. Hospital General Universitario de Valencia Dra. Ana Blasco. Hospital General Universitario de Valencia

08:05 - 08:25 Bibliometrics and science: importance of indicators in the research career Dra. Rut Lucas. Universidad de Valencia

08:25 - 08:45 What to do after the BSc? Dr. Rafael Sirera. Hospital General Universitario de Valencia

08:45 - 09:05 What comes after the PhD? Dra. Deborah Burks. Centro de Investigación Príncipe Felipe director, Valencia

09:05 - 09:25 How to choose the right mentor Dra. Alba Maiques. CERU representative, London - UK Dr. Juan Rodríguez Vita. CERFA representative, Heideberg - Germany

09:25 - 09:45 Spin off: from research to company Dra. África Gonzalez. Sociedad Española de Inmunología president

09:45 - 10:05 Clinical trials in cancer Dr. Vicente Guillem. Instituto Valenciano de Oncología - IVO, Valencia

10:05 - 10:35 Discussion

10:45 - 11:00 WELCOME AND INTRODUCTION Dr. Carlos Camps. Hospital General Universitario de Valencia Dr. Arkaitz Carracedo. CIC bioGUNE, Derio

11:00 - 12:30 KEY SESSION: TUMOR HETEROGENEITY Chairs: Dr. Joaquin Arribas. Ciberonc director, Madrid Dra. Rosa Mª Farràs. Centro de Investigación Príncipe Felipe - CIPF, Valencia

11:00 - 11:20 Breast cancer heterogeneity Dr. Emilio Alba. Hospital Regional Universitario de Málaga y Virgen de la Victoria, Málaga

Valencia, 6th - 7th - 8th November 2018

16th ASEICA INTERNATIONAL CONGRESS

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Valencia, 6th - 7th - 8th November 2018

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11:20 - 11:40 Metastasis-initiating cells within tumors Dr. Roger Gomis. Instituto de Recerca Oncológica, Barcelona

11:40 - 12:10 Plenary lecture: Cancer evolution Dr. David Posada. Universidad de Vigo

12:10 - 12:30 Discussion

12:30 - 13:50 JOINT SYMPOSIUM ASEICA - SEI: PRECISION MEDICINE WHEN THERE IS NOT A DRAGGABLE TARGET: IMMUNONCOLOGY

Chairs: Dr. Rafael Sirera. Hospital General Universitario de Valencia Dra. África González. Sociedad Española de Inmunología president

12:30 - 12:50 Novel antibody-based strategies in cancer immunotherapy TBC

12:50 - 13:10 Use of dendritic cells for anti-tumor therapy Dra. Jolanda de Vries. Radboud University, Nijmegen - Netherlands

13:10 - 13:30 TILs and its applicability in cancer Dra. Alena Gros. Vall d’Hebron Institut d’Oncologia - VHIO, Barcelona

13:30 - 13:50 Discussion

13:50 - 15:15 POSTER VIEWING AND LUNCH

15:15 - 16:10 SHORT COMMUNICATIONS · Parallel sessions

TUMOR BIOLOGYChairs: Dr. Francisco X. Real. Centro Nacional de Investigaciones Oncológicas-CNIO, Madrid

Dra. María Abad. Vall d’Hebron Institut d’Oncologia-VHIO, Barcelona

TUMOR TREATMENT Chairs: Dra. Edurne Berra. CIC bioGUNE, Derio

Dr. Bruno Sainz. Universidad Autónoma de Madrid

15:15 - 15:21 Short Comunication 1 Short Comunication 1

15:21 - 15:27 Short Comunication 2 Short Comunication 2

15:27 - 15:33 Short Comunication 3 Short Comunication 3

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16:15 - 16:35 EDUCATIONAL SYMPOSIUM, OPTIMIZING THE TREATMENT IN PROSTATE CANCER

Chairs: Dr. Arkaitz Carracedo. CIC bioGUNE, Derio Dr. Miguel Ángel Climent. Instituto Valenciano de Oncología-IVO, Valencia

16:15 - 16:35 Exploiting paracrine signaling in prostate cancer for therapy Dr. Andrea Alimonti. Institut of Oncology Research, Bellinzona-Switzerland

16:35 - 16:55 The changing care of metastatic prostate cancer treatment Dra. Begoña Mellado. Hospital Clínic de Barcelona

16:55 - 17:15 Discussion

17:15 - 18:15 JOINT SYMPOSIUM ASEICA - SEOM: MILESTONES OF THE TRANSLATIONAL RESEARCH IN ONCOLOGY IN 2018

Chairs: Dr. Xosé R. Bustelo. Centro de Investigación del Cáncer, Universidad de Salamanca-CSIC Dra. Ruth Vera. Complejo Hospitalario de Navarra, Pamplona

17:15 - 17:35 From the clinician’s point of view Dr. Juan Manuel Sepúlveda. Hospital Universitario 12 de Octubre, Madrid

17:35 - 17:55 From the researcher’s point of view Dr. Piero Crespo. Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Santander

17:55 - 18:15 Discussion

18:15 - 19:00 POSTER VIEWING AND COFFEE BREAK

www.aseica.es

15:33 - 15:48 Discussant comments Discussant comments

15:48 - 15:54 Short Comunication 4 Short Comunication 4

15:54 - 16:00 Short Comunication 5 Short Comunication 5

16:00 - 16:10 Discussant comments Discussant comments

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19:00 - 20:25 COOPERATION IN PUBLIC-PRIVATE INNOVATION: NEW TECHNOLOGIES

Chairs: Dr. Enrique Grande. MD Anderson Cancer Center. Madrid Dr. Julian Carretero. Universidad de Valencia

19:00 - 19:20 Polymer therapeutics as anticancer nanomedicines Dra. Mª Jesús Vicente. Hospital Principe Felipe de Valencia

19:20 - 19:30 PITX2 DNA-methylation, a novel validated marker in high-risk breast cancer Dr. Olaf G. Wilhelm. Therawis Pharma GmbH. Munich, Germany

19:30 - 19:40 Clinical use of Guardant 360 in gastrointestinal tumors Dra. Clara Montagut. Hospital del Mar, Barcelona

19:40 - 19:50 Liquid biopsies as important tool for the implementation of precision oncology. The example of OncoBEAM EGFR mutation assessment in lung cancer Dra. Silvia Calabuig Fariñas. Hospital General Universitario de Valencia

19:50 - 20:00 Study of biomarkers using NGS in liquid biopsy Dra. Atocha Romero. Hospital Universitario Puerta del Hierro Majadahonda, Madrid

20:00 - 20:10 EPICUP, an example of cooperative innovation in PP Dr. Sebastián Morán. Head Dx Development Ferrer

20:10 - 20:25 Discussion

21:00 h YOUNG ONCOLOGISTS NETWORKING EVENING (Only for assistents under 45 years old) Venue: ADEIT | Fundación Universidad-Empresa de la Universidad de Valencia Plaza Virgen de la Paz, 3, 46001 Valencia

16th ASEICA INTERNATIONAL CONGRESS

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08:00 - 09:18 PROFFERED AND SHORT COMMUNICATIONS · Parallel sessions

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LIQUID BIOPSY AND BIOMARKERS Chairs: Dra. Laura Muinelo. Complejo Hospitalario Universitario de Santiago de CompostelaDr. Ernest Nadal. Institut Català d’Oncologia-ICO Hospital Duran i Reynals, Barcelona

TUMOR MICROENVIRONMENTChairs: Dra. Verónica Torrano. CIC bioGUNE, DerioDr. Manuel Valiente. Centro Nacional de Investigaciones Oncológicas - CNIO, Madrid

08:00 - 08:10 Short Comunication 1 Short Comunication 1

08:10 - 08:20 Short Comunication 2 Short Comunication 2

08:20 - 08:30 Short Comunication 3 Short Comunication 3

08:30 - 08:45 Discussant comments Discussant comments

08:45 - 08:51 Short Comunication 1 Short Comunication 1

08:51 - 08:57 Short Comunication 2 Short Comunication 2

08:57 - 09:03 Short Comunication 3 Short Comunication 3

09:03 - 09:18 Discussant comments Discussant comments

09:30 - 10:30 JOINT SYMPOSIUM ASEICA - INTERNATIONAL SOCIETY OF LIQUID BIOPSY ELUCIDATING THE COMPLEXITY OF LIQUID BIOPSIES

Chairs: Dr. Eloisa Jantus. Hospital General Universitario de Valencia Dr. María José Serrano. Centro Pfizer-Universidad de Granada-Junta de Andalucía de Genómica e Investigación Oncológica - GENYO

09:30 - 09:50 Exosomes and liquid biopsy Dr. Héctor Peinado. Centro Nacional de Investigaciones Oncológicas - CNIO, Madrid

09:50 - 10:10 cfDNA in liquid biopsy Dra. Ana Vivancos. Vall d’Hebron Institut d’Oncologia - VHIO, Barcelona

10:10 - 10:30 Discussion

10:30 - 11:00 OFFICIAL OPENING 7

Valencia, 6th - 7th - 8th November 2018

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11:00 - 11:30 POSTER VIEWING AND COFFEE BREAK

11:30 - 12:30 EDUCATIONAL SYMPOSIUM, OPTIMIZING THE TREATMENT IN 2019: MECHANISMS OF RESISTANCE TO ONCOGENIC DRIVERS IN LUNG CANCER: FUTURE APPROACHES IN THE LANDSCAPE

Chairs: Dr. Bartomeu Massuti. Hospital General Universitario de Alicante Dr. Rafael López. Complejo Hospitalario Universitario de Santiago de Compostela

11:30 - 11:50 Facing up novel resistances with irreversible EGFR- kinase inhibitors in lung cancer Dra. Noemi Reguart. Institut d’Investigacions Biomèdiques August Pi i Sunyer-IDIBAPS, Hospital Clínic de Barcelona

11:50 - 12:10 Is there an optimal sequencing approach to overcome resistances in ALK-driven NSCLC tumors? Dra. Enriqueta Felip. Hospital Universitari Vall d’Hebron, Barcelona

12:10 - 12:30 Discussion

12:30 - 14:00 CIBERONC SESSION

14:00 - 15:30 POSTER VIEWING AND LUNCH

15:30 - 16:30 EDUCATIONAL SYMPOSIUM, OPTIMIZING THE TREATMENT IN 2019: TMB. FRONTIERS IN IMMUNOTHERAPY

Chairs: Dr. Luis Montuenga. Centro de Investigación Médica Aplicada-CIMA. Universidad de Navarra, Pamplona Dr. Mariano Provencio. Hospital Universitario Puerta del Hierro-Majadahonda, Madrid

15:30 - 15:50 Influences of the neoantigenic load in the response to immunotherapy. Consequences for the development of new medicines. Dr. Luis Paz-Ares. Hospital Universitario 12 de Octubre, Madrid

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15:50 - 16:10 Identifying and targeting modulators of immune checkpoint controls in melanoma Dra. Marisol Soengas. Centro Nacional de Investigaciones Oncológicas-CNIO, Madrid

16:10 - 16:30 Discussion

16:30 - 18:20 KEY SESSION: NOT ALL ROADS LEAD TO ROME: ONCOGENIC SIGNALING BEYOND THE TUMOR CELL Chairs: Dr. Rubén Pío. Centro de Investigación Médica Aplicada-CIMA, Universidad de Navarra, Pamplona Dra. María Muñoz Caffarel. Instituto de investigación sanitaria BioDonostia, Donostia

16:30 - 16:50 Aberrant PI3K signaling at the core of vascular malformations Dra. Mariona Graupera. Institut d’Investigació Biomèdica de Bellvitge - IDIBELL, Barcelona

16:50 - 17:10 Anticancer therapies for vascular malformations Dr. Jaume Mora. Hospital Sant Joan de Déu, Barcelona

17:10 - 17:30 Cancer stem cells as drug target Dr. Guillem Argilés. Hospital Universitari Vall d’Hebron, Barcelona

17:30 - 18:00 Plenary lecture: Oncogenic reprogramming of the tumor stroma Dra. Kairbaan Hodivala-Dilke. Barts Cancer Institute, London - UK

18:00 - 18:20 Discussion

18:30 - 20:00 ASEICA WOMEN SESSION

18:30 – 18:35 Presentation

18:35 – 19:20 Inspirational Lecture: Yes, we can  Sra. Elisa Martin. Chief Technology Officer IBM Spain

19:20 – 19:50 Discussion

19:50 – 20:00 Award for the professional development of women in science 21:30 h SPEAKERS DINNER

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08:00 - 09:20 YOUNG SESSION CIBER-SEAP-SEBBM: NOVEL APPROACHES IN CANCER RESEARCH

Chairs: Dra. Anna Bigas. Hospital del Mar - Parc de Salut Mar de Barcelona Dr. Jose Palacios. Hospital Universitario Ramón y Cajal, Madrid Dr. Pedro Lazo-Zbikowski. Centro de Investigación del Cáncer, Universidad de Salamanca - CSIC

08:00 - 08:20 Molecular Biophysics and its application to study DNA processing machines involved in DNA break repair Dr. Fernando Moreno. Centro Nacional de Biotecnología, Madrid

08:20 - 08:40 Comparative pathology and molecular cancer characterization of tumors Dra. Mireia Castillo. Chamapalimaud foundation, Lisboa - Portugal

08:40 - 09:00 Secretome & proteomic & microenvironment Dr. Josep Villanueva. Vall d’Hebron Institut d’Oncologia - VHIO, Barcelona

09:00 -09:20 Discussion

09:20 - 10:50 PRESIDENTIAL SESSION

Chairs: Dr. Carlos Camps. Hospital General Universitario de Valencia Dr. Arkaitz Carracedo. CIC bioGUNE, Derio Dr. Alfredo Carrato. Hospital Universitario Ramón y Cajal, Madrid

09:20 - 09:50 Plenary lecture: Pi3K from biology to cancer and back Dr. Bart Vanhaesebroek. UCL Cancer Institute, London - UK

09:50 - 10:05 Oral Comunication 1

10:05 - 10:20 Oral Comunication 2

10:20 - 13:35 Oral Comunication 3

10:35 - 10:50 Discussion

10:50 - 11:40 PRIZES AND BURSARIES

11:40 - 12:25 POSTER VIEWING AND COFFEE BREAK

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12:25 - 13:15 PLENARY SESSION ASEICA-AECC-FUNDACIÓ LA CAIXA COMMITTED TO RESEARCH: R + D + I REPORT IN CANCER IN SPAIN

Chairs: Dra. Gema Moreno. Universidad Autónoma de Madrid & MD Anderson Cancer Center, Madrid Dra. Angélica Figueroa. Instituto de Investigación Biomédica de A Coruña - INIBIC, A Coruña Dr. Jesús Paramio, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas-CIEMAT, Madrid

12:25 - 12:40 Presentation Dra. Angélica Figueroa. Instituto de Investigación Biomédica de A Coruña - INIBIC, A Coruña

12:40 - 13:15 Discussion Dra. Marta Puyol. AECC representative Sra. Montserrat Capdevila. Fundació la caixa representative Dr. Joaquin Arribas. Ciberonc director ASPIC representative Dra. Alba Maiques. CERU representtaive, London - UK Dr. Juan Rodríguez Vita. CERFA representative, Heideberg - Germany

13:15 - 14:15 EDUCATIONAL SYMPOSIUM, OPTIMIZING THE TREATMENT IN 2019: NEW TREATMENT OPTIONS IN CYCLIN INHIBITORS

Chairs: Dr. Alberto Ocaña. Complejo Hospitalario Universitario de Albacete Dr. Agustí Barnadas. Hospital de la Santa Creu i Sant Pau. Barcelona

13:15 - 13:35 Where are they now and where are they headed in the future Dra. Eva Ciruelos, Hospital Universitario 12 de Octubre, Madrid

13:35 - 13:55 The spinning of CDK4/6 inhibitors in Hormone-Positive Breast Cancer Care Dra. Ana Lluch. Hospital Clínico Universitario de Valencia

13:55 - 14:15 Discussion

14:15 - 15:30 POSTER VIEWING AND LUNCH

15:30 - 16:00 ASEICA ASSEMBLY (Only for ASEICA’s members)

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16:00 - 17:00 CONTROVERSIAL SESSION: PRECLINICAL CANCER MODELS Chairs: Dr. Alberto Muñoz. Instituto de Investigaciones Biomedicas Alberto Sols IIBM, UAM-CSIC Madrid Dr. Jesús Paramio. Centro de Investigaciones Energéticas, Medioambientals y Tecnológicas-CIEMAT, Madrid

16:00 - 16:20 PDX and PDO as preclinical cancer model Dr. Héctor García Palmer. Hospital Universitari Vall d’Hebron, Barcelona

16:20 - 16:40 Transgenic mice as preclinical cancer model Dr. Arkaitz Carracedo. CIC bioGUNE, Derio

16:40 - 17:00 Discussion

17:00 - 17:30 FAREWELL CONFERENCE: HOW EMBRYOS CAN HELP TO UNDERSTAND CANCER CELL BIOLOGY Chairs: Dr. Gabriel Capellà. Institut d’Investigació Biòmedica de Bellvitge - IDIBELL, Barcelona Dra. Montserrat Sánchez Céspedes. Institut d’Investigació Biòmedica de Bellvitge - IDIBELL, Barcelona

17:00 - 17:30 How embryos can help to understand cancer cell biology Dra. Mª Angela Nieto, Instituto de Neurociencias CSIC-UMH, Alicante

17:30 - 17:40 CLOSING

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SPONSORED SESSIONS

EDUCATIONAL SYMPOSIUM, OPTIMIZING THE TREATMENT IN 2019:PROSTATE CANCER

EDUCATIONAL SYMPOSIUM, OPTIMIZING THE TREATMENT IN 2019:NEW TREATMENT OPTIONS IN CYCLIN INHIBITORS

EDUCATIONAL SYMPOSIUM, OPTIMIZING THE TREATMENT IN 2019:TMB. FRONTIERS IN IMMUNOTHERAPY

EDUCATIONAL SYMPOSIUM, OPTIMIZING THE TREATMENT IN 2019:MECHANISMS OF RESISTANCE TO ONCOGENIC DRIVERS INLUNG CANCER: FUTURE APPROACHES IN THE LANDSCAPE

JOINT SYMPOSIUM ASEICA - SEOM: MILESTONES OF THE TRANSLATIONAL RESEARCH IN ONCOLOGY IN 2018

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JOINT SYMPOSIUM ASEICA - SEI:PRECISION MEDICINE WHEN THERE IS NOT A DRAGGABLE TARGET: IMMUNONCOLOGY

JOINT SYMPOSIUM ASEICA - INTERNATIONAL SOCIETY OF LIQUID BIOPSY ELUCIDATING THE COMPLEXITY OF LIQUID BIOPSIES

COOPERATION IN PUBLIC-PRIVATE INNOVATION: NEW TECHNOLOGIES

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Partial collaboration

Partial collaboration

VENUEUniversidad Politécnica de ValenciaEdificio Rectorado · Sala Paranimfo. Camí de Vera S/n, Valencia

WEBSITEOn the symposium website you can consult all the information about the symposium: Scientific program, speakers, committees, inscriptions, headquarters, abstracts competition. Also, and once the event is finished, you will find the presentations and photos of it.

LANGUAGESMain languages: English and Spanish

REGISTRATIONOnly proper accredited attendants will be able to access the venue; please, make sure your lanyard is visible all the time. The registration fee covers: access to all the scientific sessions, official documentation, certificate of attendance, coffee breaks and lunches. To register access the inscription form through the symposium website www.aseica.es

CERTIFICATE OF ATTENDANCEIf you wish to receive a certificate of attendance, please fill in the form on-line; scanning the QR code or through the event website. For more information, consult the Technical Secretariat of the symposium.

ACREDITATIONAccreditation requested to the Spanish System of Continuing Medical Education of the Community of Valencia. Attendance to the entire course is mandatory in order to obtain the accreditation.

ABSTACTS COMPETITIONPlease check the terms and conditions of the competition at the symposium website: www.aseica.es

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Until 30th September

Until 31st October

On site

Students and Predocs Members ASEICA-ASPIC-EACR-SEOM-SEOR-SEBBM-SEAP-AECC-CERU-CERFA-CIBERONC-FESEO

150 € 200 € 300 €

Students and Predocs non-members 300 € 350 € 450 €

Members ASEICA-ASPIC-EACR-SEOM-SEOR-SEBBM-SEAP-AECC-CERU-CERFA-CIBERONC-FESEO

275 € 350 € 400 €

Non-members 600 € 650 € 700 €

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PLATINUM

SILVER

BRONZE

COLABORATORS

GOLD

Endorsed by:

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16th ASEICA INTERNATIONAL CONGRESS