1441276_81018062EN_Manual_tiamo_2_4_Process_analysis (1).pdf

tiamo 2.4 (for Process Analysis)

Manual8.101.8062EN

Metrohm AGCH-9100 HerisauSwitzerlandPhone +41 71 353 85 85Fax +41 71 353 89 [email protected]

tiamo 2.4 (for Process Analysis)

Manual

8.101.8062EN 09.2013 ek/doe

TeachwareMetrohm AGCH-9100 [email protected]

This documentation is protected by copyright. All rights reserved.Although all the information given in this documentation has beenchecked with great care, errors cannot be entirely excluded. Should younotice any mistakes please send us your comments using the addressgiven above.Documentation in additional languages can be found onhttp://documents.metrohm.com.

Table of contents

tiamo 2.4 (for Process Analysis) III

Table of contents1 Introduction 1

1.1 Welcome to tiamo ................................................................ 11.2 Operation .............................................................................. 21.3 Device integration ................................................................ 31.4 Method editor ....................................................................... 41.5 Database ................................................................................ 51.6 Communication ..................................................................... 61.7 Conformity ............................................................................ 71.8 Versions ................................................................................. 81.9 Online help ............................................................................ 91.10 What is new in tiamo 2.4? ................................................. 101.10.1 New features ......................................................................... 101.10.2 Improvements ....................................................................... 111.10.3 Fixed bugs and problems ....................................................... 12

2 General program functions 182.1 Program parts ..................................................................... 182.1.1 Program parts ........................................................................ 182.1.2 Workplace - Desktop ............................................................. 192.1.3 Database - Desktop ............................................................... 192.1.4 Method - Desktop ................................................................. 202.1.5 Configuration - Desktop ........................................................ 202.1.6 Manual control - Desktop ...................................................... 212.2 Login/password protection ................................................ 212.2.1 General information on Login/password protection .............. 212.2.2 Login ..................................................................................... 222.2.3 Manual logout ...................................................................... 232.2.4 Automatic logout .................................................................. 232.2.5 Change password .................................................................. 232.3 Electronic signatures .......................................................... 242.3.1 Rules for electronic signatures ................................................ 242.3.2 Procedure for electronic signatures ........................................ 252.3.3 Signature Level 1 ................................................................... 262.3.4 Signature Level 2 ................................................................... 272.3.5 Delete signatures level 2 ........................................................ 292.4 Formula editor .................................................................... 302.4.1 Input field .............................................................................. 302.4.2 Calculation algorithms ........................................................... 312.4.3 Variables ............................................................................... 33

Table of contents

IV tiamo 2.4 (for Process Analysis)

2.4.4 Operators/functions ............................................................... 562.4.5 Molar mass calculator ............................................................ 902.5 Editing ................................................................................. 912.5.1 Select date ........................................................................... 912.5.2 Text editor ............................................................................. 912.5.3 Hyperlink ............................................................................... 932.6 E-mail ................................................................................... 932.6.1 Send E-mail ........................................................................... 93

3 Workplace 943.1 Workplace - General ........................................................... 943.1.1 Workplace - Definition ........................................................... 943.1.2 Workplace - Desktop ............................................................. 943.1.3 Workplace - Menu bar ........................................................... 943.1.4 Workplace - Toolbar .............................................................. 973.1.5 Workplace - Subwindows ...................................................... 973.1.6 Workplace - Functions ........................................................... 983.1.7 Views .................................................................................... 993.2 Workplaces ....................................................................... 1023.2.1 Create new workplace ......................................................... 1023.2.2 Edit workplace ..................................................................... 1033.2.3 Displaying workplaces ......................................................... 1033.2.4 Close workplace .................................................................. 1043.3 Sample tables ................................................................... 1043.3.1 Editing the sample table ...................................................... 1043.3.2 Sample table - Properties ..................................................... 1143.3.3 Sample table manager ......................................................... 1233.4 Sample assignment table ................................................. 1253.4.1 Sample assignment table .................................................... 1253.4.2 Sample assignment ............................................................. 1263.4.3 Enter assignment ID ............................................................. 1273.5 Text templates .................................................................. 1283.5.1 List of text templates ........................................................... 1283.5.2 Edit text template ................................................................ 1283.6 Run subwindow ................................................................ 1293.6.1 Run - General ...................................................................... 1293.6.2 Run test ............................................................................... 1293.6.3 Single determination ............................................................ 1303.6.4 Determination series ............................................................ 1463.7 Subwindow Method ......................................................... 1773.7.1 Method window - General .................................................. 1773.7.2 Method window - Zoom ..................................................... 1773.7.3 Method window - Live modifications ................................... 1783.7.4 Method window - Cancel command .................................... 1793.8 Subwindow Live display .................................................. 1793.8.1 Live display - General ........................................................... 179

Table of contents

tiamo 2.4 (for Process Analysis) V

3.8.2 Live display - Tracks ............................................................. 1803.8.3 Live display - Application note ............................................. 1813.8.4 Live display - Messages ........................................................ 1813.8.5 Live display - Properties ........................................................ 1813.9 Subwindow Report ......................................................... 1893.9.1 Report - General ................................................................. 1893.9.2 Latest report ....................................................................... 1893.9.3 Selected report ................................................................... 1893.9.4 Report overview ................................................................. 1893.9.5 Properties report overview ................................................... 190

4 Database 1914.1 Database - General ........................................................... 1914.1.1 Database - Definition ........................................................... 1914.1.2 Database - Desktop ............................................................. 1914.1.3 Database - Menu bar ........................................................... 1924.1.4 Database - Toolbar .............................................................. 1964.1.5 Database - Subwindows ...................................................... 1984.1.6 Database - Functions ........................................................... 1984.1.7 Views .................................................................................. 1994.2 Database display .............................................................. 2024.2.1 Open database ................................................................... 2024.2.2 Select database ................................................................... 2044.2.3 Display single database ....................................................... 2044.2.4 Display databases next to one another ................................. 2054.2.5 Display databases one below the other ................................ 2054.2.6 Close database ................................................................... 2054.3 Managing databases ........................................................ 2054.3.1 Managing databases ........................................................... 2054.3.2 Creating a new database ..................................................... 2064.3.3 Renaming a database .......................................................... 2074.3.4 Deleting a database ............................................................. 2074.3.5 Database properties ............................................................. 2074.3.6 Backing up a database manually .......................................... 2114.3.7 Restoring a database ........................................................... 2124.4 Templates .......................................................................... 2134.4.1 Report templates ................................................................. 2134.4.2 Templates for control chart .................................................. 2494.4.3 Curve overlay templates ....................................................... 2534.4.4 Export templates ................................................................. 2594.5 Determination overview .................................................. 2964.5.1 Determination overview - General ........................................ 2964.5.2 Determination overview - Functions ..................................... 3024.6 Subwindow Information .................................................. 3484.6.1 Information - Overview ........................................................ 3484.6.2 Information - Determination ................................................ 3484.6.3 Information - Method .......................................................... 352

Table of contents

VI tiamo 2.4 (for Process Analysis)

4.6.4 Information - Sample ........................................................... 3534.6.5 Information - Configuration ................................................. 3554.6.6 Information - Messages ....................................................... 3634.6.7 Information - Determination comment ................................ 3634.7 Subwindow Results .......................................................... 3644.7.1 Results - General .................................................................. 3644.7.2 Results - Results overview .................................................... 3644.7.3 Results - Raw data ............................................................... 3664.7.4 Results - Calculation # ......................................................... 3774.7.5 Results - Properties .............................................................. 3784.8 Subwindow Curves ........................................................... 3794.8.1 Curves - General .................................................................. 3794.8.2 Curves - Measuring point list ................................................ 3814.8.3 Curves - Monitoring report .................................................. 3814.8.4 Properties ............................................................................ 382

5 Method 3985.1 Method - General ............................................................. 3985.1.1 Method - Definition ............................................................. 3985.1.2 Method - Desktop ............................................................... 3995.1.3 Method - Menu bar ............................................................. 3995.1.4 Method - Toolbar ................................................................ 4015.1.5 Method - Functions ............................................................. 4035.2 Method editor ................................................................... 4045.2.1 Creating a new method ....................................................... 4045.2.2 Opening a method .............................................................. 4045.2.3 Select method .................................................................... 4065.2.4 Editing a method ................................................................. 4085.2.5 Checking a method ............................................................. 4135.2.6 Saving a method ................................................................. 4135.2.7 Modification comment on method ...................................... 4155.2.8 Print method report ............................................................. 4165.2.9 Closing a method ................................................................ 4165.3 Managing methods .......................................................... 4175.3.1 Managing methods ............................................................. 4175.3.2 Renaming a method ............................................................ 4195.3.3 Copying a method ............................................................... 4195.3.4 Moving a method ................................................................ 4195.3.5 Deleting a method ............................................................... 4205.3.6 Sending a method to ........................................................... 4205.3.7 Exporting a method ............................................................. 4215.3.8 Importing a method ............................................................ 4215.3.9 Renaming an imported method ........................................... 4215.3.10 Signing methods ................................................................. 4225.3.11 Showing the method history ................................................ 4275.4 Method groups ................................................................. 4285.4.1 Manage method groups ..................................................... 428

Table of contents

tiamo 2.4 (for Process Analysis) VII

5.4.2 Edit method groups ............................................................. 4295.5 Tracks ................................................................................ 4305.5.1 Tracks - General ................................................................... 4305.5.2 Track types .......................................................................... 4315.5.3 Edit tracks ............................................................................ 4365.6 Commands ........................................................................ 4375.6.1 Commands - General ........................................................... 4375.6.2 Track commands ................................................................. 4415.6.3 Titration commands ............................................................. 4565.6.4 Measuring commands ......................................................... 9355.6.5 Calibration commands ....................................................... 10955.6.6 Dosing commands ............................................................. 11585.6.7 Automation commands ..................................................... 12155.6.8 Result commands .............................................................. 12415.6.9 Communications commands .............................................. 12595.6.10 Various commands ............................................................ 12805.6.11 Process analysis commands ............................................... 1295

6 Configuration 13196.1 Configuration - General ................................................. 13196.1.1 Configuration - Definition .................................................. 13196.1.2 Configuration - Desktop .................................................... 13196.1.3 Configuration - Menu bar .................................................. 13206.1.4 Configuration - Toolbar ..................................................... 13226.1.5 Configuration - Subwindows ............................................. 13226.1.6 Configuration - Functions .................................................. 13236.1.7 Views ................................................................................ 13246.2 Administration ................................................................ 13276.2.1 User administration ........................................................... 13276.2.2 Security settings ................................................................. 13366.2.3 Program administration ..................................................... 13466.3 Configuration data ......................................................... 13516.3.1 Export/import .................................................................... 13516.3.2 Backing up/restoring .......................................................... 13576.3.3 Templates .......................................................................... 13606.3.4 Options ............................................................................. 13736.4 Audit Trail ....................................................................... 13766.4.1 Audit Trail - General ........................................................... 13766.4.2 Audit Trail table ................................................................. 13806.5 Subwindow Devices ....................................................... 13926.5.1 Configuration - Devices ..................................................... 13926.5.2 Device table ....................................................................... 13936.5.3 Device properties ............................................................... 13976.6 Subwindow Titrants/Solutions ...................................... 13986.6.1 Titrants/Solutions - General ................................................ 13986.6.2 Solution table .................................................................... 1398

Table of contents

VIII tiamo 2.4 (for Process Analysis)

6.6.3 Solution properties ............................................................ 14026.7 Sensors subwindow ....................................................... 14216.7.1 Sensors - General ............................................................... 14216.7.2 Sensor table ...................................................................... 14216.7.3 Sensor properties ............................................................... 14256.8 Subwindow Colorimetric sensors ................................. 14476.8.1 Colorimetric sensors - General ........................................... 14476.8.2 Table - Colorimetric sensors ............................................... 14476.8.3 Properties - Colorimetric sensor ......................................... 14506.9 Subwindow Global variables ......................................... 14596.9.1 Configuration - Common variables ................................... 14596.9.2 Table of common variables ................................................ 14596.9.3 Common variable properties .............................................. 14626.10 Subwindow Global variables ......................................... 14686.10.1 Configuration - Global variables ......................................... 14686.10.2 Table of global variables .................................................... 14686.10.3 Properties Global variables ................................................. 14716.11 Subwindow Sample solutions (TC conductivity) ......... 14776.11.1 Sample solutions (TC conductivity) - General ...................... 14776.11.2 Sample solutions (TC conductivity) table ............................. 14776.11.3 Sample solutions (TC conductivity) properties ..................... 14816.12 Subwindow Rack data ................................................... 14846.12.1 Configuration - Rack data ................................................. 14846.12.2 Rack table ......................................................................... 14846.12.3 Rack properties .................................................................. 1487

7 Devices 14947.1 874 Oven Sample Processor .......................................... 14947.1.1 874 Oven Sample Processor - Overview ............................. 14947.1.2 Properties - General ........................................................... 14947.1.3 Properties - Tower ............................................................. 14957.1.4 Properties - Rack ................................................................ 14967.1.5 Properties - MSB # ............................................................. 14967.1.6 Properties - Oven ............................................................... 14987.1.7 Properties - GLP ................................................................ 14997.2 867 pH Module ............................................................... 15017.2.1 867 pH Module - Overview ................................................ 15017.2.2 Properties - General ........................................................... 15017.2.3 Properties - Measuring inputs ............................................ 15027.2.4 Properties - MSB # ............................................................. 15037.2.5 Properties - GLP ................................................................ 15047.3 864 Robotic Balance Sample Processor ....................... 15067.3.1 864 Robotic Balance Sample Processor - Overview ............. 15067.3.2 Properties - General ........................................................... 15077.3.3 Properties - Tower # .......................................................... 15087.3.4 Properties - Rack ................................................................ 1510

Table of contents

tiamo 2.4 (for Process Analysis) IX

7.3.5 Properties - Initial position ................................................. 15117.3.6 Properties - MSB # ............................................................. 15127.3.7 Properties - GLP ................................................................ 15137.4 856 Conductivity Module .............................................. 15157.4.1 856 Conductivity Module - Overview ................................. 15157.4.2 Properties - General ........................................................... 15157.4.3 Properties - Measuring inputs ............................................ 15167.4.4 Properties - MSB # ............................................................. 15177.4.5 Properties - GLP ................................................................ 15187.5 855 Robotic Titrosampler .............................................. 15207.5.1 855 Robotic Titrosampler - Overview ................................. 15207.5.2 Properties - General ........................................................... 15217.5.3 Properties - Measuring inputs ............................................ 15227.5.4 Properties - Tower # .......................................................... 15237.5.5 Properties - Rack ................................................................ 15257.5.6 Properties - Initial position ................................................. 15267.5.7 Properties - MSB # ............................................................. 15277.5.8 Properties - GLP ................................................................ 15287.6 846 Dosing Interface ..................................................... 15307.6.1 846 Dosing Interface - Overview ........................................ 15307.6.2 Properties - General ........................................................... 15307.6.3 Properties - MSB # ............................................................. 15317.6.4 Properties - GLP ................................................................ 15337.7 814/815 USB Sample Processor .................................... 15357.7.1 814/815 USB Sample Processor - Overview ........................ 15357.7.2 Properties - General ........................................................... 15357.7.3 Properties - Tower # .......................................................... 15367.7.4 Properties - Rack ................................................................ 15387.7.5 Properties - Initial position ................................................. 15397.7.6 Properties - MSB # ............................................................. 15407.7.7 Properties - GLP ................................................................ 15427.7.8 Configuration Robotic arm ................................................ 15437.7.9 External position ............................................................... 15457.8 778/789 Sample Processor ............................................ 15457.8.1 778/789 Sample Processor - Overview ............................... 15457.8.2 Properties - General ........................................................... 15467.8.3 Properties - Tower # .......................................................... 15477.8.4 Properties - Rack ................................................................ 15497.8.5 Properties - MSB # ............................................................. 15507.8.6 Properties - RS-232 ............................................................ 15517.8.7 Properties - GLP ................................................................ 15527.9 774 Oven Sample Processor .......................................... 15547.9.1 774 Oven Sample Processor - Overview ............................. 15547.9.2 Properties - General ........................................................... 15547.9.3 Properties - Tower ............................................................. 15557.9.4 Properties - Rack ................................................................ 15567.9.5 Properties - Dosing device .................................................. 1557

Table of contents

X tiamo 2.4 (for Process Analysis)

7.9.6 Properties - Oven ............................................................... 15577.9.7 Properties - Gas ................................................................. 15587.9.8 Properties - RS-232 ............................................................ 15597.9.9 Properties - GLP ................................................................ 15597.10 756/831 Coulometer ...................................................... 15617.10.1 756/831 Coulometer - Overview ........................................ 15617.10.2 Properties - General ........................................................... 15617.10.3 Properties - RS-232 ............................................................ 15627.10.4 Properties - GLP ................................................................ 15637.11 730 Sample Changer ...................................................... 15657.11.1 730 Sample Changer - Overview ........................................ 15657.11.2 Properties - General ........................................................... 15657.11.3 Properties - Tower ............................................................. 15667.11.4 Properties - Rack ................................................................ 15677.11.5 Properties - Dosing device .................................................. 15687.11.6 Properties - RS-232 ............................................................ 15697.11.7 Properties - GLP ................................................................ 15697.12 712 Conductometer ....................................................... 15717.12.1 712 Conductometer - Overview ......................................... 15717.12.2 Properties - General ........................................................... 15717.12.3 Properties - RS-232 ............................................................ 15727.12.4 Properties - GLP ................................................................ 15737.13 089 Photometer ............................................................ 15757.13.1 089 Photometer - Overview ............................................... 15757.13.2 Properties - General ........................................................... 15757.13.3 Properties - Settings ........................................................... 15767.13.4 Properties - Adjustment ..................................................... 15777.13.5 Properties - MSB # ............................................................. 15787.13.6 Properties - GLP ................................................................ 15797.14 Avantes spectrometer .................................................... 15817.14.1 Avantes spectrometer - Overview ...................................... 15817.14.2 Properties - General ........................................................... 15827.14.3 Properties - Settings ........................................................... 15837.14.4 Properties - Detector .......................................................... 15847.14.5 Properties - Calibration ...................................................... 15847.14.6 Properties - Dark spectrum ................................................. 15857.14.7 Properties - Reference spectrum ........................................ 15867.14.8 Properties - Correction spectrum ........................................ 15877.14.9 Properties - GLP ................................................................ 15887.15 Barcode reader ............................................................... 15907.15.1 Barcode reader - General ................................................... 15907.15.2 Barcode reader - Overview ................................................. 15917.15.3 Properties - General ........................................................... 15927.15.4 Properties - Settings ........................................................... 15937.15.5 Properties - GLP ................................................................ 15937.15.6 Establish a connection to the barcode reader ..................... 1595

Table of contents

tiamo 2.4 (for Process Analysis) XI

7.16 RS-232 device ................................................................. 15957.16.1 RS-232 device - Overview .................................................. 15957.16.2 Properties - General ........................................................... 15967.16.3 Properties - RS-232 ............................................................ 15977.16.4 Properties - GLP ................................................................ 15997.16.5 Establish a connection to the RS-232 device ...................... 16007.17 Titrando .......................................................................... 16017.17.1 Titrando - Overview ........................................................... 16017.17.2 Properties - General ........................................................... 16017.17.3 Properties - Measuring inputs ............................................ 16027.17.4 Properties - MSB # ............................................................. 16037.17.5 Properties - GLP ................................................................ 16057.17.6 Load new program version ............................................... 16067.18 Titrino .............................................................................. 16077.18.1 Titrino - Overview .............................................................. 16077.18.2 Properties - General ........................................................... 16087.18.3 Properties - Int. Dosing device D0 ...................................... 16097.18.4 Properties - Ext. Dosing device D# ...................................... 16107.18.5 Properties - RS-232 ............................................................ 16117.18.6 Properties - GLP ................................................................ 16127.19 Balances .......................................................................... 16147.19.1 Balance - Overview ............................................................ 16147.19.2 Properties - General ........................................................... 16147.19.3 Properties - RS-232 ............................................................ 16157.19.4 Properties - GLP ................................................................ 16177.19.5 Establish a connection to the balance ................................ 16187.20 IO controller .................................................................... 16197.20.1 IO controller - Overview ..................................................... 16197.20.2 Properties - General ........................................................... 16197.20.3 Properties - Settings ........................................................... 16207.20.4 Properties - Digital inputs ................................................... 16217.20.5 Properties - Digital outputs ................................................ 16257.20.6 Properties - Analog inputs .................................................. 16287.20.7 Properties - Analog outputs ............................................... 16307.20.8 Properties - Controller ........................................................ 16337.20.9 Properties - GLP ................................................................ 16527.21 Stepping Motor Controller ............................................ 16547.21.1 Stepping Motor Controller - Overview ............................... 16547.21.2 Properties - General ........................................................... 16547.21.3 Properties - Settings ........................................................... 16557.21.4 Properties - Digital inputs ................................................... 16567.21.5 Properties - Digital outputs ................................................ 16607.21.6 Properties - Stepping motors ............................................. 16637.21.7 Properties - GLP ................................................................ 1666

8 Manual control 16688.1 Manual control - General ............................................... 1668

Table of contents

XII tiamo 2.4 (for Process Analysis)

8.2 Manual control - Desktop .............................................. 16688.3 Manual control - Device selection ................................ 16698.4 Manual control - Functions ........................................... 16698.4.1 Dosing ............................................................................... 16698.4.2 Stirring .............................................................................. 16758.4.3 Remote functions .............................................................. 16778.4.4 Sample changer functions .................................................. 16798.4.5 Measuring ......................................................................... 16898.4.6 Process analysis functions .................................................. 16958.5 Manual control - Graphical display ............................... 1714

9 How to proceed? 17159.1 Audit Trail ....................................................................... 17159.1.1 Opening Audit Trail .......................................................... 17159.1.2 Filtering Audit Trail ........................................................... 17159.1.3 Exporting Audit Trail ......................................................... 17169.1.4 Archiving Audit Trail ......................................................... 17179.1.5 Deleting Audit Trail ........................................................... 17189.2 Backup ............................................................................ 17199.2.1 Backing up a database ....................................................... 17199.2.2 Restoring the database ...................................................... 17219.2.3 Backing up configuration data ........................................... 17229.2.4 Restoring configuration data .............................................. 17239.2.5 Backing up methods .......................................................... 17249.2.6 Archiving the Audit Trail .................................................... 17269.3 Determinations ............................................................... 17289.3.1 Starting single determination ............................................. 17289.3.2 Starting determination series ............................................. 17299.3.3 Search for determinations .................................................. 17319.3.4 Filter determinations .......................................................... 17319.3.5 Signing determination ....................................................... 17339.3.6 Export determinations ....................................................... 17359.3.7 Importing determinations .................................................. 17369.3.8 Deleting determinations .................................................... 17379.3.9 Make the determination version current ............................ 17389.3.10 Reprocessing determinations ............................................ 17399.3.11 Printing determination report ............................................ 17439.3.12 Printing determination overview ....................................... 17449.4 Databases ....................................................................... 17459.4.1 Database in general ........................................................... 17459.4.2 Opening a database .......................................................... 17469.4.3 Closing a database ............................................................ 17469.4.4 Creating a database ........................................................... 17479.4.5 Backing up a database ....................................................... 17489.4.6 Restoring the database ...................................................... 17499.4.7 Deleting a database ........................................................... 1750

Table of contents

tiamo 2.4 (for Process Analysis) XIII

9.5 Configuration data ......................................................... 17519.5.1 Configuration data in general ............................................ 17519.5.2 Exporting configuration data ............................................. 17519.5.3 Importing configuration data ............................................. 17529.5.4 Backing up configuration data ........................................... 17529.5.5 Restoring configuration data .............................................. 17549.6 Methods .......................................................................... 17559.6.1 Opening a method ............................................................ 17559.6.2 Closing a method .............................................................. 17559.6.3 Creating a new method ..................................................... 17569.6.4 Creating a new method ..................................................... 17569.6.5 Deleting a method ............................................................. 17579.6.6 Export method .................................................................. 17589.6.7 Import methods ............................................................... 17589.6.8 Signing method ................................................................. 17599.6.9 Making previous method version current .......................... 17619.6.10 Print method report .......................................................... 17619.6.11 Backup methods ............................................................... 17629.7 Method groups ............................................................... 17649.7.1 Creating method group .................................................... 17649.7.2 Deleting method group .................................................... 17659.8 Sample tables ................................................................. 17659.8.1 Create sample table .......................................................... 17659.8.2 Edit sample table .............................................................. 17669.8.3 Loading working sample table .......................................... 17689.8.4 Edit working sample table ................................................. 17689.9 Reports ............................................................................ 17699.9.1 Creating report template .................................................. 17699.9.2 Edit report template .......................................................... 17719.9.3 Printing determination report ............................................ 17729.9.4 Printing determination overview ....................................... 17739.10 No help available ............................................................ 1774

Index 1775

1 Introduction

tiamo 2.4 (for Process Analysis) 1

1 Introduction1.1 Welcome to tiamo

Introduction

tiamo = titration and moretiamo is a control and database software for titrators, dosing devices andsample changers and makes complete laboratory automation possible. It isfor that reason that the name tiamo stands for "titration and more" -tiamo can do more than just titrate.tiamo is the successor software to TiNet and Workcell. Metrohm thus pro-vides a uniform software product for laboratory automation. Companieswith international operations can use the same software platform at allsites around the globe for the processing of their samples and exchangedata and methods without loss.Overview of the main program features Easy-to-operate and easily configurable user interface Simple integration of devices and accessories Convenient method editor Database-based program with client/server functionality Wide range of import and export functions FDA compatibility in accordance with 21 CFR Part 11 Comprehensive online help

1.2 Operation

2 tiamo 2.4 (for Process Analysis)

Program versions What is new in tiamo 2.4?Overview of the most important information concerning pro-cess analysis instruments under tiamo Process analysis instruments

IO controller Stepping Motor Controller

Process analysis - Commands Process analysis - Manual control

1.2 OperationIntroductionThe modern user interface makes it simple for users to find their wayaround tiamo. All commands and control elements are located where youwould expect. The bar on the left edge of the screen gives you access tothe five basic elements of tiamo:

Workplace Database Method Configura-tion

Manual

Depending on the access permissions, these buttons are either visible orinvisible. The menu bar is in the upper part of the screen. It is also possiblefor the individual commands to be hidden, depending on the access per-missions.In the center of the screen, you can find the information windows withthe settings, sample entry masks, live curves or results. This view can beset individually for each user with the aid of the new Layout Manager. Asa result, users see only those windows or buttons they actually need fortheir work. This reduces the introductory period for routine users to a min-imum. Incorrect operation as a result of overcrowded screens is also athing of the past.The method and calculation templates successfully introduced withthe Titrando system are also available in tiamo. A wide range of tried-and-tested methods allow any user to create new methods quickly and simplyand to use them immediately.

1 Introduction


1.3 Device integrationIntroductiontiamo brings together the world of Titrino devices and the new genera-tion of the Titrando System under the same roof. Compatibility withexisting Metrohm devices is not a matter of course in the software sector.The entire product range of the Titrino family, which was already integra-ted in TiNet, can be used with tiamo, and this after more than 10 years onthe market! In addition, sample changers which to some extent are nolonger included in the sales program, are integrated in tiamo. That is howMetrohm secures your investments!It goes without saying that all of the models of the new Titrando genera-tion, as well as the new sample processors, are compatible with tiamo.Thus, the advantages of USB communications, such as plug-and-play orrecognition of intelligent dosing systems, can be used with tiamo to theirfullest extent. Even a mixed operation made up of older RS-232-operateddevices and newer USB devices is possible without any problem.With the process analysis version of tiamo, an IO controller integrated intothe company network can also be directly controlled by tiamo.Devices that can be used with tiamo Titrando

808, 809, 835, 836, 841, 842, 851, 852, 855, 857, 888, 890, 901,902, 904, 905, 906, 907

Titrino702, 716, 718, 719, 720, 721, 736, 751, 758, 784, 785, 794, 795,798, 799

Conductometers712, 856

KF coulometers756, 831

Sample changers730, 774, 778, 789, 814, 815, 855, 864, 874

Miscellaneous846 Dosing Interface, 859 Titrotherm, 867 pH Module, Avantes spec-trometer, 089 Photometer, balances, barcode readers, IO controllers,

1.4 Method editor


1.4 Method editorIntroductionThe new graphic method editor gets more out of your titration system.With the aid of the numerous templates, methods can be created quicklyand easily. For most routine and automated tasks, there are tried-and-tested methods available. Just a few clicks and they are adapted and readyto use.One new feature is that actions running in parallel at the same timecan now be programmed and linked. Together with the new Titrando sys-tem and the Robotic Sample Processors, a sample can be prepared whilethe previous one is being titrated. This saves time and increases the sam-ple throughput. The crowning feature is the simultaneous processing ofseveral samples. This means that one Titrando can carry out two titrationsat the same time. As a result, sample throughput is doubled!tiamo is flexible and accommodates itself to analysis procedures, and notthe other way around.Overview of functions Graphical method editor (see Chapter 5.6.1.2, page 438) Method manager (see Chapter 5.3.1, page 417) Separate management of access permissions for each method group

(see Chapter 5.4.2.3, page 429) Templates for method development and calculations (see Chapter

5.2.1, page 404) Plausibility check for methods (see Chapter 5.2.5, page 413) Comments can be added to the methods (see Chapter 5.2.4.2.9, page

412) Parallel runs (see Chapter 5.6.10.3.1, page 1285) Loop functions (see Chapter 5.6.10.4.1, page 1287)

1 Introduction


1.5 DatabaseIntroductiontiamo is based on an object-oriented database, that has proven itselfin practice. All program settings, the user administration, methods andtemplates are stored in the configuration database and the determina-tion data is stored in the determination databases defined by the user.These databases can be installed locally on the computer reserved formeasurements and make up a simple measurement system. tiamo ishowever scalable and grows with operational requirements. As soon asdata security and central data management make it necessary, tiamo isinstalled as a Client/Server configuration. The tiamo database is theninstalled on a server. All measurement and office computers work as cli-ents. All results are stored centrally in this network and can be accessedand processed by all Client PCs. All clients also access the same pool ofmethods.The new database has all the major tools necessary for management of,searching for and grouping of results. Quick filters allow the user to searchthrough thousands of determinations within seconds and to display theresult clearly. Chart plots give a fast overview of the sequence of resultsbased on time.All options for reprocessing are available to the user.Overview of functions Object-oriented Client/Server database (see Chapter 6.2.3.1, page

1346). Layout manager for the database view (see Chapter 3.1.7, page 99). Quick filter (see Chapter 4.5.2.4.3, page 306). Efficient search functions (see Chapter 4.5.2.3, page 303). Access permissions control for every database (see Chapter 4.3.5.3,

page 208). Automatic database backup (see Chapter 4.3.5.4, page 209). Control charts (see Chapter 4.5.2.17, page 345). Reprocess determinations (see Chapter 4.5.2.6, page 316).

1.6 Communication


1.6 CommunicationIntroductionThe decisive factor for the acceptance of PC-controlled analysis systems isbeing able to integrate it easily and economically in existing laboratoryinformation systems, central databases and long-term archiving systems.tiamo is communicative. LIMS systems can easily import work lists intothe tiamo sample table and control them remotely, without extra mod-ules. Data generated in tiamo can be exported in XML format. Connec-tion to LIMS systems on the market is thus not difficult. Export to long-term archiving systems such as NuGenesis SDMS or Scientific SoftwareCyberlab is also supported.The Report generator provides a simple and flexible solution for creat-ing analysis reports. The report generator allows you to freely define thereport templates. It is therefore possible at any time to display one ormore determinations in a choice of PDF layouts or as a printout.A special feature is that tiamo messages, error messages or results fromthe method run can be sent to the user by e-mail.Overview of functions Import of sample data (see Chapter 3.3.1.6, page 111). Various export formats , e.g. XML, CSV, SLK (see Chapter 4.4.4.2.1,

page 260). Automatic data export, e.g. to NuGenesis SDMS, Scientific Software

CyberLAB, etc. (see Chapter 5.6.8.5.1, page 1258). Report designer (see Chapter 4.4.1.4.1.1, page 216). E-mail functions for status messages, error messages or results (see

Chapter 2.6, page 93). Import of external measured values (see Chapter 5.6.3.11.2, page

934).

1 Introduction


1.7 ConformityIntroductiontiamo also sets new standards with respect to the fulfilling of GMP, GLPand FDA requirements. The latest quality standards and validation pro-cedures were implemented in developing and programming the software.tiamo has been designed to fulfill the FDA directive 21 CFR Part 11and the customer-specific interpretations. This is evidenced by a Certificateof Conformity. A centralized user administration defines the access per-missions for program functions, methods and results, whereby any num-ber of users with freely definable access profiles are possible. The systemadministrator can conveniently access the user administration from anytiamo client. Access to the software is password-protected and there is achoice of tiamo or Windows login.The use of digital signatures makes it possible to sign methods andresults. There are two signatures available with differing properties. Withthe first signature (Level 1, Review) the user confirms that he has program-med the method correctly or carried out the analysis correctly. With thesecond signature (Level 2, Release) the method or result is released andprotected against further modifications. It is thus possible to mirror cus-tomized workflows in tiamo.All data is organized according to the version and protected againstunauthorized access, modification or deletion in the database. The data-base itself controls access to the data in network operation and providesarchiving and restore functions.The "Audit Trail" protocols all actions by the user and all major systemprocesses.Conformity relevant properties of tiamo Conformity is priority in development and validation. Centralized user administration (see Chapter 6.2.1.1, page 1327). Detailed access permissions (see Chapter 6.2.1.2.2, page 1330). Password protection under tiamo or Windows (see Chapter 6.2.2.2,

page 1337). Digital signature on two levels (see Chapter 2.3, page 24). One signature each for methods and results. Documentation of all method and result modifications (see Chapter

4.5.2.14, page 343). Traceability thanks to detailed Audit Trail (see Chapter 6.4.1.1, page

1376).

1.8 Versions


1.8 VersionsIntroductiontiamo is available in three sales versions which differ with regard to thescope of functions. An upgrade is possible at any time. tiamo 2.4

lighttiamo 2.4

fulltiamo 2.4

multi

Product 6.6056.241 6.6056.242 6.6056.243 Maximum numberof Metrohminstruments per PC

2 unlimited unlimited

Compatible withFDA 21 CFR Part11

User administra-tion

Security settings Traceability ("AuditTrail")

Client/server sup-port

Number of licen-ses

1 1 3

Additional licensesas an option

XML data exportto LIMS

Parallel titrations Upgrade possible

1 Introduction


1.9 Online helpIntroduction

Calling up the helptiamo has an extensive and detailed online help that can be accessed intwo ways: General call With the menu item Help tiamo help, or the symbol

the online help with the topic Welcome to tiamo is opened. Fromthere you can jump via Contents, Index, Search or personal Favor-ites to the desired topic.

Context-sensitive call With the function key [F1] on the keyboardyou can jump directly to the topic which will show information on theactive element in tiamo (dialog window, tab).

Symbols and conventionsThe following symbols and styles are used in this documentation:

Device table Link to another help topic in which information isshown for the marked term.

Method Dialog textDesignation for names of parameters, menu items,tabs and dialog windows in the software.

100 Designation for parameter values in input fields.File New Menu or menu item; Path needed to reach a certain

point in the program.[Next] Button

Formula editorFormulae can be entered in fields with this symbol,and the formula editor opens when you click on thesymbol (see Chapter 2.4, page 30).Instruction stepCarry out these steps in the sequence shown.CautionThis symbol draws attention to a possible damage ofinstruments or instrument parts.NoteThis symbol marks additional information and tips.

1.10 What is new in tiamo 2.4?


1.10 What is new in tiamo 2.4?This chapter describes the changes that were made from tiamo 2.3 totiamo 2.4.

1.10.1 New featuresGeneral New determination examples for conductometric titrations are

included in the delivery (was already implemented in tiamo 2.3, Patch1).

It is now possible to carry out two-channel measurements using twoUSB2 Avantes spectrometers that are connected with each other witha synchronization cable.

Method program partThe flash rate can now be defined for the commands that can be carriedout with the Avantes spectrometer (MEAS Ref, MEAS Spec, MEASOpt, MEAS Opt Conc, CAL MEAS Opt).New instrument firmwareThe new versions allow the instruments listed below to be operateddirectly via the computer's USB3.0 connectors.Instruments Firmware version814 USB Sample Processor 5.814.0025815 Robotic USB Sample Processor XL 5.815.0026846 Dosing Interface 5.846.0022851 Titrando 5.851.0012852 Titrando 5.852.0012855 Robotic Titrosampler 5.855.0014856 Conductivity Module 5.856.0022857 Titrando 5.857.0022859 Titrotherm 5.846.0022864 Robotic Balance Sample Processor XL 5.815.0026867 pH Module 5.867.0022874 USB Oven Sample Processor 5.874.0012888 Titrando 5.888.0022

1 Introduction


Instruments Firmware version890 Titrando 5.890.0022901 Titrando 5.901.0022902 Titrando 5.902.0022904 Titrando 5.904.0022905 Titrando 5.905.0022906 Titrando 5.906.0022907 Titrando 5.907.0022

Manual program part Dosing devices and stirrers can now be controlled in the section of the

089 Photometer. In two-channel instrument setups, it is possible to control the flash rate

for the instrument for the measuring channel.

1.10.2 ImprovementsGeneral Starting with version 2.4, tiamo also runs on Windows 8 operating sys-

tem. The installation manual now contains a description of the directories

that can be stored in a network. E-mails can now be sent simultaneously to several recipients. The Calculation algorithms Statistics chapter in the online help

has been revised.Workplace program part For IO and stepper motor controllers, it is possible to access the inputs

from two simultaneously active workplaces, so that determinations canproceed in parallel (was already implemented in tiamo 2.3, Patch 1).

If an instrument required in the method does not exist, the message009-032 Device not OK is displayed instead of 009-117 Devicenot ok. The new message also contains the corresponding commandname, in addition to the instrument name.

The determination of the transmission factor (MEAS TMF command)has been optimized.

Database program part If a regular spectrum is measured with the Avantes spectrometer

(MEAS Spec), it is now possible to modify the evaluation areas duringthe reprocessing of the determination.



In the Calibration curve/Calibration data dialog window, the num-ber of decimal places for Variance has been increased from 1 to 3 forCAL LOOP pH, CAL LOOP Conc and ELT LOOP.

Method program part New method examples are supplied for the 864 validation. They are

stored in the directory...\examples\methods\english\Automation\864 Validation methods.

In the MET Cond command, the lower limit of the threshold value ofthe minimum and maximum evaluation has been lowered on theAdditional evaluations tab.

The off selection for the Control range parameter is described in theonline help in more detail for the commands SET and KFT.

In the CAL LOOP Conc command, the selection for the Number ofstandards parameter has been raised from 5 to 9.

A recommendation has been added in the Standard addition -Overview chapter in the online help.

The description of the principle of titration and the optimization of theparameters has been improved in the STAT - Overview chapter in theonline help.

Variance is now also available as the VAR command variable in thecommands CAL LOOP pH, ELT LOOP and CAL LOOP Conc.

The default value for the stirring rate of the 089 Photometer has beenincreased to 5. This modification affects the commands MEAS TMF,MEAS Opt, MEAS Opt Conc and CAL MEAS Opt.

Configuration program part The limitation to two instruments applies only for Metrohm instru-

ments (Titrino, Titrando, etc.). That means that balances and othergeneric (i.e. non-Metrohm) instruments can be included without limita-tion (was already implemented in tiamo 2.3, Patch 1).

The online help did not describe how signing affects the number oflogin attempts, i.e. the relationship between signing and login moni-toring.

1.10.3 Fixed bugs and problemsGeneral Beginning with tiamo 2.3 (Build 98), communication between software

and devices has been optimized (was already implemented in tiamo2.3, Patch 1).

1 Introduction


Client ID was output as text in various places (in the header of PDFreports and the report templates, in the Information subwindow onthe Determination tab in the Database program part, in the GlobalVariables subwindow on the Global Variable tab in the Configura-tion program part). The associated value, however, corresponded tothe computer name. Client ID has now been replaced with Com-puter name (the error was already eliminated in tiamo 2.3, Patch 1).

Workplace program part If a method was programmed in which a check at the time of the start

was required for one or several method variables of the type Number(e.g. the Sample size) or Date/Time and which contained an ERRORtrack, the exception wizard appeared in the Workplace program partafter the 014-152 Field empty message was exited when the deter-mination was started (tiamo crashed) (this error was already eliminatedin tiamo 2.3, Patch 1).

If a method was written in which the file name did not have the exten-sion .pdf in the REPORT command in the PDF file field (completelyforgotten or only the period forgotten, e.g. abc or abcpdf), then thiswould lead to a crash at the start of a determination (the error wasalready eliminated in tiamo 2.3, Patch 1).

If the digital output of the Avantes spectrometer was used (CTRL com-mand) while a measuring command using the same device was alsopresent in the method, then the message 014-122 Device occupiedappeared (the error was already eliminated in tiamo 2.3, Patch 1).

In the View Properties menu item, the properties of the respectivelive display were always displayed as Properties Live display insteadof Properties Live display # (the error was already eliminated intiamo 2.3, Patch 1).

If it is determined during the start test that the wavelength of the cali-bration of the colorimetric sensor does not match the wavelength ofthe light source of the 089 Photometer in the MEAS Opt Conc com-mand, then the message 014-042 Incorrect wavelength appears.Instead of the wavelength value of the colorimetric sensor calibration,the wavelength value of the light source of the 089 Photometer wasspecified in the message (the error was already eliminated in tiamo 2.3,Patch 1).

The stop conditions for the commands DIGITAL IN and ANALOG INdid not function, although the maximum running time did (the errorwas already eliminated in tiamo 2.3, Patch 1).

In the ELT MEAS command for the electrode test, the drift was notevaluated at the correct time. This resulted in the sensor rating beingtoo strict.

If a measuring command contained in a separate track was called froma loop, then the command's indexed variables were not available afterthe first run.



If, in a REPORT command, all options were selected in the Reportoutput section (Printer, PDF file and Send e-mail), then it couldhappen that e-mails were not sent during the run.

If Calibration data monitoring was enabled for a conductivity sen-sor and the validity for the calibration had expired, then no messagewas displayed in the method run of a conductivity measurement,MEAS Cond, and a titration, MET Cond.

No message was displayed while the CAL Cond command was beingcarried out when the new cell constant was outside the limit valuesdefined for the conductivity sensor.

The DBL command variable, which indicates the total time for process-ing the command in s, yielded incorrect times for the commandsMEAS Ref, MEAS Spec and CAL Spec.

If a standard addition was performed with no sample size entry, tiamocrashed.

The 016-003 Invalid position message used wrong parameters(instrument name).

If, on the Determination series tab in the Run subwindow, a newline was added to the working sample table, then the method wasentered in the new line also when the Method check box was deacti-vated in the Copy automatically into next determination sectionunder [Sample table] Properties... Edit.

When a method consisting of several parallel tracks was run, two dif-ferent tracks were displayed at the same time in the live displays. Whenyou selected Quit in the context menu while hovering with the cursorover one of the two live displays, then both tracks were canceled.

In the CAL MEAS Opt command, no check was made during starttest as to whether the Wavelength measuring parameter correspon-ded with the wavelength of the calibration of the colorimetric sensor.

The MEAS TC Cond command was not executed correctly in determi-nations for the temperature coefficient measurement of the conductiv-ity. When the start temperature was reached, the actual measurementwas not started, i.e., there was no live display of the curve. Instead, thetext Waiting for data... was still displayed. The error message013-258 Invalid TC conductivity appeared when the stop time wasreached; the determination was canceled after the confirmation of theerror message.

Database program part If a determination was carried out with intelligent electrodes, then the

ADC data (ADC type and serial number) of the analog (non-intelligent)measuring input to which the iConnect was connected was stored inthe Database, on the Configuration tab in the Information sub-window (this error was already eliminated in tiamo 2.3, Patch 1).

1 Introduction


If a determination was carried out with the 089 Photometer, then theblank value was not subtracted in the database from the raw data IMEand EME (initial and end measured values, respectively) associatedwith the commands MEAS Opt and MEAS Opt Conc (this error wasalready eliminated in tiamo 2.3, Patch 1).

If statistically linked determinations that also contained as results suchthings as the slope, the axis intercept and the correlation coefficient forlinear regressions (variables SLO, ITC, COR) were recalculated in sucha way that a determination or a result was switched off, then the recal-culated results of slope, axis intercept and correlation were not correct(this error was already eliminated in tiamo 2.3, Patch 1).

If report templates with modified curve properties with regard to thedefault templates supplied were imported from tiamo 1.x, then the set-tings for the curve properties were reset to the default values after theimport.

The program occasionally crashed when generating a PDF with areport template.

In tiamo 2.3, Patch 1, the information on the Thermoprobe was nolonger displayed on the Configuration tab in the Information sub-window in the case of determinations involving thermometric titration.

If the ENTER key was pressed directly after the reprocessing dialog wasopened (without having made any modification), tiamo crashed.

The value of the ETR variables was not output correctly in the calcula-tions.

In the commands STDADD dos and STDADD auto, no entries werepresent for the parameters of the solution (solution name, concentra-tion, production date, titer, date of titer determination and titermethod) on the Configuration tab in the Information subwindow.In addition, the titer was not correctly stored.

Recalculating a thermometric determination in which the TET com-mand was not run through (no measuring point list) caused a crash.

Method program part An 867 pH Module present in the device configuration could in fact be

selected as Device type in the ELT MEAS command, but not asDevice name. This led to a situation where the electrode test couldnot be carried out with the 867 pH Module (the error was alreadyeliminated in tiamo 2.3, Patch 1).

The device 846 Dosing Interface could not be selected in the PORTcommand. This led to a situation where the PORT command couldnot be performed with this kind of device, even though the firmwaresupported this (the error was already eliminated in tiamo 2.3, Patch 1).

The description of Fill automatically at end was not correct in theonline help for the ADD command (the error was already eliminated intiamo 2.3, Patch 1).



If a new stepper motor was created in the STEPPING MOTOR com-mand on the Stepping motors tab or the properties of an existingone viewed, then the title of the dialog window was Method varia-ble - (instead of STEPPING MOTOR #, e.g. similar to the DIGITALOUT command) (the error was already eliminated in tiamo 2.3, Patch1).

If a method containing the KFC command was imported from tiamo1.x into tiamo 2.x, an error message was displayed during the run. Theuser had to select the sensor again and save the method in order tomake it runnable again.

The maximum run time was not correctly observed in the commandsLOOP, DIGITAL IN and ANALOG IN.

In the online help, the input range for the maximum run time was notcorrect in the DIGITAL IN command on the Stop criteria tab.

The formula for filling rate 2 for tandem dosing has been corrected inthe online help.

The command variables beginning with RS, CV or GV were not cor-rectly displayed for the CALC command in the formula editor in thevariable tree.

If not defined was selected as device name, then the device type wasnot indicated in the method parameters in the method report and inthe Fixed report.

If the method parameter report of a method containing the releasecommands RLS DOS and/or RLS DEV was output in the program partMethod or Database, the corresponding fields were not output inthe generated PDF file.

Configuration program part If a barcode reader and a balance were included first in the device con-

figuration for the light version, then it was no longer possible toinclude Metrohm devices (the error was already eliminated in tiamo2.3, Patch 1).

The incorrect text designation for the colorimetric sensors was used(Sensor instead of Colorimetric sensor) in the user administrationunder "Access rights for group 'Group designation', Configuration,Functions" (the error was already eliminated in tiamo 2.3, Patch 1).

The online help for the Limit values for colorimetric sensor 'Name of the colorimetric sensor' dialog window was missing (theerror was already eliminated in tiamo 2.3, Patch 1).

After a pH calibration, the calibration date is also entered on the Cali-bration data tab with the sensors, among other things. If, after a suc-cessful calibration, the intelligent sensor was deleted from the configu-ration and then included again, then the Date ELT could be seen inthe Calibration date field (the error was already eliminated in tiamo2.3, Patch 1).

1 Introduction


In the online help for Export configuration data and Import con-figuration data, the descriptions for Export templates and Elec-trode type templates were not available (the error was already elimi-nated in tiamo 2.3, Patch 1).

If you cannot log in within the number of attempts specified in thesecurity settings and if at the same time the Message by e-mailoption is enabled, then an e-mail will be sent to the specified address.Client name was output as text in the subject line of this e-mail, andthe associated value corresponded to the name of the computer;Client name was replaced by Computer name (the error wasalready eliminated in tiamo 2.3, Patch 1).

If the settings in the user administration were output as a PDF, then itcould happen that the PDF file did not correspond with the settings inthe software for some elements.

The input range for the titer value of a solution was modified in theonline help.

If the table of colorimetric sensors was sorted according to the date,tiamo crashed.

At least one titrant with invalid titer existed in the Titrants/Solutionssubwindow. If the table was then sorted according to titer, then noth-ing was displayed in this program part (empty display).

If a pH calibration or an electrode test was carried out with an intelli-gent sensor on one system (tiamo and Titrando) and the sensor wasthen transferred to another system, then the Calibration tempera-ture field on the Calibration data tab was empty.

If Monitor TC data was enabled for a sample solution (TC conductiv-ity) and the validity for the TC data had expired, then no message wasdisplayed during the method run of a measurement.

Manual program part If the measurement of a spectrum with the Avantes spectrometer was

canceled by clicking on [Stop], the [Stop] button correctly changed to[Start], but the recording of the spectrum continued (the error wasalready eliminated in tiamo 2.3, Patch 1).

When trying to approach a lift height greater than 90 mm with the774 Oven Sample Processor, the program was unexpectedly finished.

A table with the gas flow factors for various carrier gases enabling thecorrect determination of the gas flow in the 874 USB Oven SampleProcessor has been added to the online help.

2.1 Program parts


2 General program functions2.1 Program parts2.1.1 Program parts

Allgemeine Programmfunktionentiamo has five different program parts which can be opened by click-ing on the corresponding symbol in the vertical bar on the left. The sym-bol for the opened program part is shown in color, the symbols for theother program parts in black and white. The menus, symbol bars and con-tent of the main window depend on the program part currently opened.Program part workplace Opening/closing workplaces Starting single determinations and determination series Sample tables

Program part database Opening/Closing databases Managing databases Reprocessing Creating report templates

Program part method Opening/Closing existing methods Creating new methods Managing methods

Program part configuration Configuring devices, solutions, sensors, common variables and rack

data Security settings User administration Program administration Audit Trail

2 General program functions


Program part manual Manual control of devices

NOTE

Access to the individual program parts can be deactivated in the useradministration. In this case, the corresponding symbols are hidden.

2.1.2 Workplace - DesktopProgram part: Workplace

Workplace symbol

Clicking on the workplace symbol in the vertical bar on the left opens theprogram part Workplace while, at the same time, the workplace symbolis shown in color. The upper left corner of the symbol contains a blackfield displaying the number of workplaces currently opened (see Chapter3.2.3.1, page 103).ElementsThe desktop of the program part Workplace comprises the following ele-ments: Workplace-specific menu bar. Workplace-specific toolbar. Main window in which up to 5 subwindows can be displayed.

2.1.3 Database - DesktopProgram part: Database

Database symbol

Clicking on the database symbol in the vertical bar on the left opens theprogram part Database while, at the same time the database symbol is

2.1 Program parts


shown in color. The upper left corner of the symbol contains a black fielddisplaying the number of databases currently opened (see Chapter 4.2.2,page 204).ElementsThe desktop of the program part Database comprises the following ele-ments: Database-specific menu bar. Database-specific toolbar. Main window in which up to 6 subwindows can be displayed.

2.1.4 Method - DesktopProgram part: Method

Method symbol

Clicking on the method symbol in the vertical bar on the left opens theprogram part Method while, at the same time the method symbol isshown in color. The upper left corner of the symbol contains a black fielddisplaying the number of methods currently opened (see Chapter 5.2.3,page 406).ElementsThe desktop of the program part Method comprises the following ele-ments: Method-specific menu bar. Method-specific toolbar. Main window, in which several methods can be opened but only two

methods can be shown at the same time.

2.1.5 Configuration - DesktopProgram part: Configuration

Configuration symbol

Clicking on the configuration symbol in the vertical bar at the left opensthe program part Configuration while, at the same time the configura-tion symbol is shown in color.



ElementsThe desktop of the program part Configuration comprises the followingelements: Configuration-specific menu bar. Configuration-specific toolbar. Main window in which up to 6 subwindows can be displayed.

2.1.6 Manual control - DesktopProgram part: Manual Control

Manual Control symbol

If you click on the Manual symbol in the vertical bar on the left margin,the program part Manual Control will be opened in its own window,while the Manual symbol will be shown in color at the same time.ElementsThe desktop of the program part Manual control comprises the follow-ing elements: Selecting device Functions/Parameters Graphic function

2.2 Login/password protection2.2.1 General information on Login/password protection

Program parts: Workplace / Database / Method / Configuration

Login into tiamotiamo can be configured so that all users have to log in with their username and password and this data is automatically checked. Thisrequires a User administration to be set up and the correspondingSecurity settings to be made. This data is saved in the configurationdatabase. In the case of client/server systems, this is on the server andapplies globally for all clients (central user administration).FDA-compliant settingsIf you are to be in compliance with the FDA, the settings on the Login/Password protection tab in dialog window Security settings must beactivated according to 21 CFR Part 11 by activating the check box Set-

2.2 Login/password protection


tings according to 21 CFR Part 11. The following conditions will thenbe complied with: A login with user name and password is required each time the

program is started. User names must be unique. Users entered once cannot be deleted. Passwords must be unique per user. None of the expired passwords

already used once by the user may be reused. Passwords must be changed according to a defined validity period. The number of login attempts is limited. If this number is exceeded,

the user will automatically be set to the status inactive.ActionsIf the login is activated, the following actions can be performed: Log in at program start Manual logout Automatic logout Change password

2.2.2 LoginProgram parts: Workplace / Database / Method / ConfigurationIf both the options Enforce login with user name and Enforce loginwith password are activated in the Security settings, the dialog win-dow Login will appear every time the program is started and after eachtime the user logs out.

UserEntering a short name for the user.Entry 24 characters

PasswordPassword entry.Entry 24 characters

NOTE

Users who log in for the first time or users whose status has been resetfrom disabled or removed back to enabled, must log in with theStart password (see Chapter 6.2.1.3.1, page 1334) specified by theadministrator. Afterwards, the window Change password will auto-matically be opened, in which a new password has to be entered.



[Change password]Opens the window Change password, in which the new password hasto be entered and confirmed.

[Cancel]The login is canceled, the program is terminated.

2.2.3 Manual logout Menu item: Workplace / Database / Method / Configuration File LogoutA logged in user can logout at any time with the menu item File Log-out.... The logout options defined in the Security settings apply. Afterthe logout the Login appears, allowing a new user to log in.

2.2.4 Automatic logoutProgram parts: ConfigurationIf the automatic logout is activated in the Security settings, the user willthen automatically be logged out after a definite waiting time if he doesnot perform any operating functions via the keyboard or mouse. After-wards the Login window opens, in which however only the same user orthe members of the same user group can log in.

NOTE

Users with administrator rights can log in in each case, and an emer-gency stop is also possible.

2.2.5 Change passwordDialog window: Login [Change password] Change password

NOTE

In tiamo, the password can only be changed if the option Passwordmonitoring by MagIC Net is set in the Security settings.

[Change password]This button in the dialog window Login opens the window Changepassword, in which the new password has to be entered and confirmed.

2.3 Electronic signatures


NOTE

The password always has to be changed before the Passwords expireevery of the password expires. For users who are logging in for the firsttime or users whose status has been reset from disabled orremovedremoved back to enabled, this window is automaticallyopened after logging in with the Start password. For Old passwordyou also need to enter the Start password specified by the Adminis-trator.

Old passwordEntry of the previous password.Entry 24 characters

New passwordEntry of the new password. The password options are defined in theSecurity settings on the tab Login/Password protection.Entry 24 characters

Confirm passwordConfirmation of the new password.Entry 24 characters

2.3 Electronic signatures2.3.1 Rules for electronic signatures

Program parts: Method / DatabaseIn tiamo, methods and determination can be electronically signed attwo levels. The following rules apply for this: Signature levels

Methods and determinations can be signed at two levels (SignatureLevel 1 and Signature Level 2) by entering the user name and pass-word.

Multiple signingMethods and determinations can be signed several times at each level.All signatures are saved and documented in the Audit Trail.

Signing at Level 1If Level 2 has been signed then no more signatures are possible atLevel 1.



Signing at Level 2Level 2 can only be signed if signatures already exist at Level 1.

Different usersThe same user may only sign on either Level 1 or Level 2.

Reason and commentEach signature must be accompanied by a reason selected from prede-fined default reasons. Additionally, a further comment can be entered.

Saved dataFor each signature, signature date, user name, full name, reason andcomments are saved.

Deleting signatures 1Signatures at Level 1 are automatically deleted again when creating anew version.

Deleting signatures 2Signatures at Level 2 can only be deleted by users who have the appro-priate rights.

Signing methodsMethods can only be signed individually.

Signature optionsThe options for electronic signatures are set in the Signatures tab inthe Security settings dialog window.

2.3.2 Procedure for electronic signaturesProgrammteile: Database / MethodMethods and determinations exhibit one of the following three states inrelation to signatures (see flow diagram): Not signed

Methods and determinations which are not signed can be deleted andchanged, a new version being created at each change.

Signed (1)When signing methods and determinations at Level 1, no new versionsare generated. If methods and determinations signed at Level 1 arechanged, a new version is generated, which no longer contains anysignatures. Methods and determinations signed at Level 1 can bedeleted.

Signed (2)When signing methods and determinations at Level 2, no new versionsare generated. Methods and determinations signed at Level 2 can nei-ther be changed nor deleted. However, it is possible to delete the sig-natures (2), whereby the signatures (1) are retained.



Modify

Modify

Not signed

Sign (1)

Signed 1

Sign (2)

Signed 2

Delete signatures 2

DeleteCreate

Delete

Modify

Delete

2.3.3 Signature Level 1Dialog window: Database Determinations Sign Signature 1... SignatureLevel 1Dialog window: Method File Method manager... Method man-ager [Sign] Signature 1... Signature Level 1In the window Signature Level 1, methods or determinations can besigned at level 1.

NOTE

Methods or determinations which have been signed at level 1 can bemodified and deleted. If the modified method or determination is savedas a new version then all existing signatures will be deleted automati-cally, i.e. the method or determination must be signed again.

InfoDisplay of information for signing and deleting signatures. The followingmessages are possible:Selection Signature possible | Signature 1 not possible

(signature 2 exists) | Signature not possible(accessed by other client)

Signature possibleThe selected method or determination can be signed.



Signature 1 not possible (signature 2 exists)The selected method or determination can no longer be signed at level1 as it has already been signed at level 2.Signature not possible (accessed by other client)The selected method or determination cannot be signed as it is alreadymarked to be signed on a different client.

UserEntry of the user name (short name).Entry 24 characters

PasswordPassword entry.Entry 24 characters

ReasonSelection from the Default reasons defined in the dialog window Secur-ity settings for the category Signature level 1.Selection 'Selection from the default reasons'

CommentEntry of a comment on the signature.Entry 1000 characters

[Sign]Sign the method or determination. The window remains open.

NOTE

Methods or determinations can only be signed at level 1 if the userbelongs to a user group with the corresponding authorization.

2.3.4 Signature Level 2Dialog window: Database Determinations Sign Signature 2... SignatureLevel 2Dialog window: Method File Method manager... Method man-ager [Sign] Signature 2... Signature Level 2In the window Signature Level 2, methods or determinations can besigned at level 2.



NOTE

Methods or determinations signed at level 2 are locked, i.e. they canneither be modified nor deleted. In order to be able to edit such meth-ods or determinations again, the signatures on level 2 must first bedeleted.

InfoInformation for signing and

Documents

1441276_81018062EN_Manual_tiamo_2_4_Process_analysis (1).pdf