141112_guide for Examination

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Graduate School of Engineering The University of Tokyo

Department of Bioengineering

B

Guide to Entrance Examination (Schedule B)

Special Selection of Foreign Students (April Admission) Masters Program

Doctoral Course

If you have any questions about this guide, contact the followings.

Administrative Office of Department of Bioengineering

113-8656 !!Tel: 03-5841-1673; Fax: 03-5841-1674;E-mail, officeJP@ bioeng.t.u-tokyo.ac.jp

Kouhei TSUMOTO, ProfessorTel: 03-5841-0835

E-mail, [email protected]

URL: http://www.bioeng.t.u-tokyo.ac.jp/


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This guide is a supplementary application handbook for preparation for the

Bioengineering entrance examination, at the University of Tokyo Graduate School of

Engineering.

()

The entrance examination will be held for special selection of foreign students (April

admission) masters program and for doctoral courses. In this guide book, we will address

what applicants need to know, the examination subjects, the schedule for the test, andinformation about the professors and the research activities in the department of

Bioengineering. Please read this guide book carefully.

If you have any questions about the entrance examination, please contact us using the

contact information indicated on the cover page.

p. 16-p. 35

If you would like more details regarding laboratory research activities or if you would like

to consult with professors with whom you wish to study, directly contact them by referring to

the staff (research) information. (p. 16-35).

http://www.bioeng.t.u-tokyo.ac.jp/

Please refer to our website regarding the details of outline of our education /research

content. (http://www.bioeng.t.u-tokyo.ac.jp/)

Please note: The Japanese language version is the authentic copy and should be

referred to when questions arise about the English language version.


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2015)

Department of Bioengineering, Graduate School of Engineering, The University of Tokyo

Special selection of foreign students (April Admission) Masters Program

and Doctoral courses

2015 Examination Information for Examinees,

1.

(p.6 10)

Day & TimeRefer to Examination Schedule, p.6 or 10 in this guidebook.

2.

15

Location

The University of Tokyo, Hongo Campus, Room56, 1stFloor, Scool of Engineering

Bldg.No.5

Subway: From Nezu station (Chiyoda line):10 min. walk.

From Todai-Mae station (Namboku line):10 min. walk.

From Hongo-Sanchome station (Marunouch line or Toei-Oedo line): 20 min.

walk.Bus: From bus stop University of Tokyo Grounds (School bus): 3 min. walk.

From bus stop Todai Seimon Mae: 5 min. walk.

Examinees must enter the examination room 15 minutes prior to the start of the

examination.

3.

1

2

3

4


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()

Items to Bring

(1)Examination admission card.

(2)Black pencils (or black mechanical pencils), an eraser, a pencil sharpener (adesktop pencil sharpener is not allowed) and a watch (watches solely with time

measurement functions are allowed).

(3)The department may notify you if there is any items to bring for specialized subject

test.

(4) Cell phone use is strictly prohibited throughout the examination. Use of a cell

phone as a watch is also prohibited. Turn off the phones and other devices, and

place them in your bag.

.

1

2

3

4

5

6

During the examination

(1) Applicants cannot leave the examination room once the exam has begun.

(2) Applicants are not allowed to go to the restroom during the examination as a general

rule.

(3) Your examination admission card must be kept on your desk at all times during the

examination.

(4) No questions regarding the examination will be allowed.

(5) Enter your examination admission number on each of the examination answer

sheets.

(6) Applicants are not permitted to take home the answer sheets or problem booklets

after the examination.


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)

Department of Bioengineering, Graduate School of Engineering, The University of TokyoThe Entrance Examination on February (Schedule B)

Special Selection of Foreign Students (April Admission) Masters Program

Guide for Applicants

p.12

1. Applicants are those who are qualified for admission to graduate school master courses,regardless of qualification acquisition date.

2. Applicants must contact and gain approval from professors with whom they wish to study.

3. Choose the professor you wish to study with on questionnaire sheetp.12,and submit it along with

the application form to the office of the School of Engineering.

4. Examination subjects are as follows:

Written Examination

Subjects

Note

English

252TOEFL-iBT

TOEFL-PBT

With application form, submit TOEFL-iBT or

TOEFL-PBT score that you had taken after

February 2012.

Specialized subject

Essay

We evaluate specialized knowledge, logical

thinking and writing communication skills on

questions about Bioengineering.

Oral Examination


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PC Windows PC

PC Windows7 Microsoft Office 2007

Word/Excel/Power Point

PC

The oral examination for the master course will require approximately 15 minute.Graduates will be asked about their research, motivation for research, and general

knowledge of the department. Prepare a Power Point presentation (fewer than 5

pages)to explain your graduate research and present it on the date of the

examination (February 3rd). Presentation should take no more than 5 minutes.

Photocopies of your presentation are not necessary. A Windows PC will be prepared

for you oral presentation with Windows 7/Microsoft Office versions of Word, Excel,

and PowerPoint. Please check compatibility with these formats, and if necessary,

bring your own PC for your presentation.

This examination will accept new entrants in April 2015.

Consultation with professors

Applicants may contact in advance professors with whom they wish to study about

research plans.

If you have any questions about the examination, contact the office written on the cover

page of this department.


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)

Special Selection of Foreign Students (April Admission) , Masters Program,Schedule B

Examination Subjects

Day & Time

Location

Items to bring

WrittenExamination

English

TOEFL

Submit official

TOEFL Score

Submit with application

documents

Specialized subject

Essay

( 9:45)

Stand by at 9:45

27(2015)22()

Monday,February 2nd

,2015

10:0011:00

5

156

Room 56,

1stFloor

Bldg.No.5

Writing

implements

Examination

admission card

Oral Examination

( 12:45)

Stand by at 12:45

27(2015)22()

Monday,February 2nd

,2015

1300

Meeting Place/

Waiting room

The same as

above

Examination

admission card

Presentation

materials

Attention Applicants who are late without a valid reason will lose the opportunity to take the exam.

(Applicants should enter the examination room or waiting room 15 minutes prior to the start of the

examination, whether written or oral.)

27(2015) 2 2 () Urgent calls on February 2nd(Mon.)

(TEL03-5841-16731651

Department of Bioengineering Office


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)

Department of Bioengineering, Graduate School of Engineering, The University of TokyoThe Entrance Examination on February (Schedule B)

Doctoral Courses

Guide for Applicants

03-5841-6038,7747

p.14

1. Applicants are those who are qualified for admission to Doctoral courses, regardless of

qualification acquisition date. However, applicants who had graduated or will graduate 6-year

medical school need a preliminary examination and a permission of School of Engineering. Please

contact the following address, and ask them concerning the entrance examination.

Tel: 03-5841-6038,7747 Office of Graduate School of Engineering

2. Applicants must contact and gain approval from the professor with whom they wish to study.

3. Choose the professor you wish to study with on questionnaire sheet p.14,and submit it along

with the application form to the office of the Department of Engineering.

4. Examination subjects are as follows:

Written Examination

Subjects

Note

English

252TOEFL-iBT

TOEFL-PBT

With application form, submit TOEFL-iBT or

TOEFL-PBT score that you had taken after

February 2013.


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Specialized subject

Essay

We evaluate specialized knowledge, logical

thinking and writing communication skills onquestions about bioengineering.

Oral Examination

()

A4

The oral examination for doctoral courses will require about 30 minutes, during which

questions about the master research thesis (or research results), motivation for

research in this department, and basic knowledge will be asked. Please prepare aPower Point Presentation File (fewer than 10 pages) to explain your graduate research,

and present it on the date of the examination (February 2nd). Presentation must be no

longer than 15 minutes. Photocopies of the presentation file are not required.

Applicants who have been carrying out masters thesis research must bring 5 copies of

the abstract as reference materials on the examination day. Abstract must be within 4

sheets, A4 size and printed only on one side.

Applicants who had completed their masters thesis research must bring the thesis

itself or a substitute. In addition, applicants must bring 5 copies of its abstract which are

prepared within 4 sheets, A4 size and printed only on one side.

PC Windows PC

PCWindows7Microsoft Office 2007Word/Excel/Power

Point PC

Windows PC and PC projector will be prepared for the oral presentation, however, please

note that the versions of Word/Excel/Power Point are Windows7, Microsoft Office 2007.

Applicants should ensure their data are compatible with the PC. If necessary, applicants may bring

and use personal PCs for presentation.


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This examination will accept new entrants in April 2015.

Consultation with professors

Applicants may contact professors with whom they wish to study.

If you have any questions about the examination, contact the office on the cover page.


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)

Doctoral Courses Schedule B

Examination Subjects

Day & Time

Location

Items to bring

Written

Examination

English

TOEFL

Submit official

TOEFL Score

Submit with application

documents

Specialized subject

Essay

( 9:45)

Stand by at 9:45

27(2015)22()

Monday,February 2nd

,2015

10:0011:00

5

156

Room 56,

1stFloor

Bldg.No.5

Writing

implements

Examination

admission card

Oral Examination

( 12:45)

Stand by at 12:45

27(2015)22()Monday,February 2

nd,2015

1300

Meeting Place/

Waiting room

The same as

the above

Examination

admission card

Presentation

materials

Attention Applicants who are late without a valid reason will lose the opportunity to take the exam.

(Applicants should enter the examination room or waiting room 15 minutes prior to the start of theexamination, whether written or oral.)

27(2015) 2 2 () Urgent calls on February 2nd(Mon.)

(TEL03-5841-16731651

Department of Bioengineering Office


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Questionnaire Sheet forSpecial Selection of Foreign Students(April Admission) Masters Program Applicants

(Name in full)

(Examinee IDnumber)

(Graduation university)

(Names of university, faculty and/or department)

(Current

address)

(Residence address andtelephone number)

TEL

(Address and telephone

number of your currentlaboratory)

TEL (Ext. )

(Name of your planned supervisor)

2(Signature or impressed stamp)

(Do not fill.)

(Be sure to obtain the approval and signature of the professor.)

.

(Describe the summary of your graduation thesis on the backside of this sheet.

This information is used for the questions in the oral examination.)


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(Name in full)

(Examinee ID

number)

(Title of your

graduation thesis)

(Summary of the research of your graduation thesis. Clearly describe the background, objective, methods,results (or latest progress) and their significances in about 200 words.)

(Do not fill.)


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Questionnaire Sheet for Doctoral Course Applicants

(Name in full)

(ExamineeID number)

(Graduation university)

(Names of university, graduate course and/or department)

(Currentaddress)

(Residence address and

telephone number)

TEL

(Address and telephonenumber of your current

laboratory)

TEL

(Ext. )

(Name of your planned supervisor)

2(Signature or impressed stamp)

(Do not fill.)

(Be sure to obtain the approval and signature of the professor.)

.

(Describe the summary of your master thesis on the backside of this sheet.

This information is used for the questions in the oral examination.)


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(Name in full)

(Examinee ID

number)

(Title of your master

thesis)

(Summary of the research of your master thesis. Clearly describe the background, objective, methods, results(or latest progress) and their significances in about 200 words.)

(Describe your motivation to do Ph.D. research in 50 words)

(Do not fill.)


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Staff(research) Information

http://www.bioeng.t.u-tokyo.ac.jp

Addresses and subjects of research for the professors of the Department of Bioengineering

are shown in the following tables:

1 Bioelectronics

Masao WASHIZU, Professor

62A4 TEL: 03-5841-6344

e-mail: [email protected]

URL: http://www.washizu.t.u-tokyo.ac.jp/

1

1

1

DNADNA-

1 DNA

Bionanotechnology based on Micro/Nano Manipulation

Novel biomanipulation technology at the single-cell and single-molecule level is

developed based on microfabrication techniques, where electrokinetic effects in

micro-structures, such as dielectrophoresis or electroosmosis, are used as tools

for manipulation. Measurements, characterization, artificial regulation of the

activities, and utilization of the components as functional devices of the cells and

biological molecules are investigated.

Subjects of Research

Molecular manipulation of DNA and its application to gene analysis

DNA-based molecular construction

Introduction of foreign substances into cells by nano-electroporation and

the measurement of cellular response

Investigation of and control over higher-order structure of chromosomal

DNA

Single-molecule manipulation of chromosomal DNA using electroosmotic

flow

Electrostatic manipulation of liquid droplets for micro-reactor applications


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Hitoshi TABATA, Professor

12 209 TEL: 03-5841-8853

e-mail: [email protected]: http://www.bioxide.t.u-tokyo.ac.jp/index.html

Hiroyuki MATSUI, Assistant Professor

12 207 TEL: 03-5841-1870


URL: http://www.bioxide.t.u-tokyo.ac.jp/index.html

()

Fusion Bioelectronics by Nanoscience

We study the interdisciplinary researches of bio and oxide electronics for

realizing secure life electronics based on human mimetic artificial

nano-materials. Human mimetic materials and biosensors are fabricated,

combined with 3D nonstructural controlled functional oxides (ZnO-nano rods),

and then combined with semi conducting technology such as MOS-FET devices.

Glass materials such as spin-glass and dipole glass (relaxors) are good

candidates for human mimetic materials. They have typical characteristics for

"Yuragi" functions similar to organisms (living things). Furthermore, the research

about bio sensor/memory devices, which are constructed by self organizing

systems such as DNA and bio-related molecules, is discussed. A new method

based on THz-spectroscopy is also being constructed for direct detection of bio

molecules, hydrogen bonds of base pairs in DNA double helixes, and that of

protein-DNA molecules.


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Ichiro SAKUMA, Professor

14 722 TEL 03-5841-7481

e-mail:[email protected]

URL: http://www.bmpe.t.u-tokyo.ac.jp/

Realization of advanced Medicine through Fusion of Engineering and

BioscienceRealization of advanced medicine based on biomedical engineering, precision

engineering, electronic engineering, measurement technology, and control

engineering utilizing recent advances of life sciences.


Surgical Robotics

Minimally Invasive Precision Guided Therapy

Optical Mapping of Cardiac Excitation

Cardiac Electrophysiology

Akira HIROSE, Professor

123TEL 03-5841-6695


URL: http://www.eis.t.u-tokyo.ac.jp/

Brain Electronics

Hirose laboratory opens a door to new interdisciplinary fields combining wirelesselectronics and brain-inspired signal/information processing to realize next

generation electronics. Many up-to-date medical imagers and sensors using


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lightwave and electromagnetic wave generate complex-amplitude data

composed of amplitude and phase as well as polarization. Such data possess

special properties different from those of traditional images. We utilize the nature

to investigate new technologies to visualize what is unseen with conventional

systems and/or to distinguish what we focus on. We also develop new antennasand wireless communication methods to link imagers and sensors to processing

computers with less burden or restriction that may occur in conventional hard

antennas and wiring environment.


Brain-like signal processing

Adaptive sensing and imaging

Flexible wireless communications


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2 Bioimaging

Yoshikazu NAKAJIMA, Associate Professor

2-11-6 314 TEL03-5841-8982


URL: http://www.image.u-tokyo.ac.jp/

3

4

Medicine meets computer science

The mission of our laboratory is to realize computerized surgery-assistance

systems. The methods developed and used by our group can provide intelligent

integration of multi-modal medical images, surgical operations captured by

high-speed optical localizers, and vital signs. They lead surgical

simulating/planning software systems, computer-assisted surgery (CAS)

systems, and high dimensional medical imaging systems such as

three-dimensional endoscopy and four-dimensional (spatio-temporal) X-ray

computer tomography imaging. Our systems using these approaches have been

introduced into practical surgery routines in several hospitals and over 200

clinical cases have been successfully reported. We also have joined and

collaborated with several research groups developing surgical robotic systems.

Mitsuru UESAKA, Professor

2-22TEL029-287-8421


URL: http://www.nuclear.jp/~kiki/uesaka/index.html

DNA

Quantum Beam Biomedical Engineering

Development of advanced compact electron linear accelerators and laser, their


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application to bioimaging and pinpoint cancer therapy, advanced treatment

planning, radiation biological analysis and R&D based medical physics.


Advanced compact accelerator/laser development

Pinpoint X-ray cancer therapy

Advanced treatment planning

Online visualization of DNA damage and repair

R&D based medical physics

Hiroyuki TAKAHASHI, Professor

535 TEL03-5841-7007

e-mail: [email protected]: http://www.n.t.u-tokyo.ac.jp/~leo/

CT(PET)

PET

Quantum Radiation Imaging and InstrumentationQuantum radiation imaging is based on advanced radiation measurements.

Microfabrication techniques are utilized for large format arrays of imaging

devices which include scintillation detectors for positron emission tomography,

superconducting microcalorimeter arrays for high-resolution X-ray fluorescence

analysis, and micropattern gas detectors for structural analysis of molecules.

Our focus is the functional imaging of biological and biomedical applications

using these advanced radiation imaging techniques.


Quantum Radiation Imaging


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10 300 TEL 03-5841-7490


URL: http://www.bee.t.u-tokyo.ac.jp/

MRI

Electromagnetic fields enable diagnosis of diseases at an early stage and

non-invasive treatment of the diseases. Our new methods of MRI enable us tovisualize anatomical structure as well as electromagnetic phenomena in

biological bodies. Our group is developing compact and user-friendly medical

equipment for use in patients' home, and flexible thin film devices which fit even

the complicated geometry of the brain surface.


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3 Mechanobioengineering

Katsuko FURUKAWA, Associate Professor 62D3 TEL03-5841-6331

e-mail: [email protected], [email protected]

URL: http://park.itc.u-tokyo.ac.jp/tissue/index.html

Tissue Engineering based on Mechanoengineering

We are trying to establish regenerative medical engineering for regenerating

living tissues in vitro, synthesizing mechanical engineering, material science and

cellular/ molecular biology. Additionally, we are also trying to elucidate unknown

mechanisms regarding how living cells sense physical stimulations such as

tensile stress, shear stress, and hydrostatic pressure at molecular levels.

Mamoru MITSUISHI, Professor

71D1 TEL03-5841-6355


URL: http://www.nml.t.u-tokyo.ac.jp/index-j.html

Surgical System based on Manufacturing System

Cutting-edge technology for medicine supported by mechanical engineering and

bioengineering.

Subects of Research

Neurosurgical system in the deep surgical field

Computer-assisted knee arthroplasty system

Remote minimally invasive surgical system Bone fracture reduction system


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Scaphoid fracture reduction system

Remote ultrasound diagnosis system

Shu TAKAGI, Professor 61A1 TEL 03-5841-6426


URL: http://www.fel.t.u-tokyo.ac.jp/takagi/takagi.html

(DDS)

Development of Minimally-Invasive Ultrasound Diagnosis & Treatment

System and Supercomputing for Biomechanics

We have been working on the topics related to medical ultrasound and human

body simulation using supercomputer. On medical ultrasound, microbubbles as

ultrasound contrast agents have been developed for the further applications of

tumor ablation, drug delivery system, gene transfection etc. On human bodysimulator, new method for biomechanical simulation using medical image data

was developed and the method has been further developed to simulate various

types of blood flows.


Minimally-invasive Treatment of Tumor using Focused Ultrasound with

Microbubbles

Medical Ultrasound for the Integrated Diagnosis and Therapy System.

Development of Ultrasound Drug Delivery System using Microbubbles Development of Vascular Network Simulator and Hemadynamometer

Blood Flow Simulations with Red Blood Cells

Takashi USHIDA, Professor

62D3 TEL03-5800-9197


URL: http://park.itc.u-tokyo.ac.jp/tissue/index.html


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From Tissue Regeneration towards to Organ Regeneration

We are trying to establish regenerative medical engineering for regenerating

living tissues in vitro, synthesizing mechanical engineering, material science,

and cellular/ molecular biology. Additionally, we are also trying to elucidate

unknown mechanisms for how living cells sense physical stimulations such as

tensile stress, shear stress and hydrostatic pressure at molecular levels.

Subects of research Regenerative engineering of cartilage under hydrostatic pressure

3D scaffold forming engineering for cartilage and bone regeneration

Non-invasive measurements for evaluating regenerated tissues

Real-time multi-imaging of intracellular signal transductions under physical

stimulations


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4 Biodevices

Takanori ICHIKI, Associate Professor

2-11-16 310 TEL03-5841-1180

e-mail: [email protected]: http://bionano.t.u-tokyo.ac.jp/

(1)

(2)

(3)

Nanobiodevice for biomolecular synthesis and analysisBased on the nano/microfabrifcation technology, we are developing various

biodevices including microfluidics and microarray chips. Our research activity covers

a wide range of technology development; from device fabrication process to practical

diagnostic system.

Subjects of research

(1) High-speed enzyme evolution system using large-scale integrated microarray

technology

(2) MicroRNA diagnostic devices for early cancer detection

(3) Platform technology for exosome diagnosis

Takehiko KITAMORI, Professor

3 6A02 TEL03-5841-7231


Kazunori MAWATSRI, Associate Professor

3 6A04 TEL03-5841-7232


URL: http://park.itc.u-tokyo.ac.jp/kitamori/

7-7 (KBIC) 212 TEL

044-223-7031



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10nm "m

Integrated Chemical Laboratory

Attainment of an unprecedented level of high-throughput diagnosis involving

bioinformation sensing and clinical analyses by means of microfluidic devices

fabricated at a micro/nano meter scale.


Thermal lens microscope Micro/Nano chemical systems

Micro/Nano channels

Teruo FUJII, Professor

4-6-1Fw604TEL03-5452-6211


URL: http://www.microfluidics.iis.u-tokyo.ac.jp/

Yukiko MATSUNAGA, Lecturer

4-6-1An701TEL03-5452-6470


URL: http://www.matlab.iis.u-tokyo.ac.jp/

Applied Microfluidic Systems - Device Technologies and Materials Science

By applying micro/nanoscale structures fabricated through softlithography processes,

we develop microfluidic devices and systems to realize new experimental setups for

biomacromolecules, cells, tissues, etc.


Fundamental Technologies of Microfluidic Devices

Material Synthesis and Processing for Biomedical Microdevices

Microfluidics for Cell Separation and Analysis


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3D Tissue Engineering using Microfluidic Technology

3D Tissue Model Systems for Medical Applications


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5 biomaterials

Yuichi TEI/Ung-il CHUNG, Professor

12 205TEL03-5841-8843/1427


URL: http://www.tetrapod.t.u-tokyo.ac.jp/

As the society ages, irreversible organ defects pose great socio-economical

problems, and much attent ion has been paid to tissue engineering and

regenerative medicine. Among the three pillars of tissue

engineering/regenerative medicine, we focus on signals and scaffolds and try to

integrate the two to create innovative implant devices, which locally act on host

cells to induce regeneration. Concretely, we aim 1) to develop high-performance

structural biomaterials by controlling 3D shape on nanometer to millimeter

scales and analyze and improve their properties. 2)to develop novel screeningmethods for bioactive factors (proteins, nucleic acids, small molecules) inducing

bone and cartilage formation, 3)to devices methods to place bioactive actors

in biomaterials and precisely control their release. Through these researches,

we eventually attempt to create intelligent implant devices that actively induce

bone and cartilage regeneration.


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Madoka TAKAI, Professor

725 TEL03-5841-7125


URL: http://www.mpc.t.u-tokyo.ac.jp/takai/index.html

(1)

(2)

(3)

Development of Highly Functional Medical Devices by Design of

Biointerface

The biointerface is created when a biomolecule (e.g., DNA, RNA, protein,antibody), and membranes, viruses, or cells touches a solid surface such asinorganic, synthetic polymer, or bio-inspired materials. The aim of our studyon biointerface science is to understand and control the behavior of suchbiological objects on the surfaces. We are developing highly functionalmedical devices for artificial organs, for medical diagnoses, and forregenerative medicine designed by the biointerface.

Kazuhiko ISHIHARA, Professor

8 731 TEL03-5841-7124


URL: http://www.mpc.t.u-tokyo.ac.jp


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Bioinspired Polymers and Their Biomedical Functions

In this laboratory, we are developing novel polymer biomaterials based on a

molecular design with strong inspirations from the surface structure of

biomembranes. That is, polymers with phospholipid polar group in the side chain

and 2-methacryloyloxyethyl phosphorylcholine (MPC) polymers were

synthesized. The MPC polymers can inhibit surface-induced clot formation

effectively, even when they contact blood in the absence of an anticoagulant.

This phenomenon was due to the reduction of plasma proteins and the

suppression of denaturation of absorbed proteins. As the molecular structure of

the MPC polymer was easily designed by changing monomer units and

composition, it could apply to surface modification of artificial organs and

biomedical devices. Moreover, we also apply the polymer biomaterials for every

bioengineering field.

Horacio CABRAL, Associate Professor

12 519 TEL03-5841-6142


URL: -


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Development of Smart Drug Delivery Systems for Diagnosis and Therapy

Nano-scaled devices are a promising platform for specific detection of

pathological targets, facilitating the analysis of biological tissues in real-time,while improving the diagnosis approaches and the efficacy of therapies.


Development of nanodevices for cancer diagnosis

Development of nanodevices for targeted cancer therapy

Targeting of metastatic disease

Targeting of tumor microenvironment

Study of the interface of nanodevices and biological surroundings

Development of pinpoint-activated drug delivery systems

6 Chemical Bioengineering

Kouhei TSUMOTO, Professor

TEL03-5449-5316


URL: http://park.itc.u-tokyo.ac.jp/phys-biochem

Biological phenomena are composed of highly organized and specific molecular

interactions. We aim to dissect these biomolecular interactions from multiple

points of view, and to screen and design ligands that control them. We also


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advance bio-medicine in the era of bio-better and bio-superior using diverse

engineering approaches. To create a new generation of diagnosis and

therapeutics, bio-physical approaches are applied to the study of

disease-related biological machineries.

Teruyuki NAGAMUNE, Professor

745 TEL: 03-5841-7328

e-mail: [email protected], [email protected]

URL: http://park.itc.u-tokyo.ac.jp/nagamune/

Creation of Super Biomolecules and Cells Far Superior to Natural Ones

and Their Applications to Biomedical Engineering Research Field

We are aiming to improve, alter, and expand the function of biomolecules, which

relate to molecular recognition and signal transductions, by using techniques

available in the field of gene engineering, protein engineering, enzyme

engineering, and chemistry. By integrating these modified functional

biomolecules, we aim to develop a technology for creation of super complex

biomelecules and cells far superior to natural ones, and to apply these materials

to the biomedical engineering research field.


Development of cell based microarray technology for functional analysis

of cells

Development of artificial receptors for controlling cellular function

Development of a cell surface modification method and its application to

medical care


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Yasuyuki SAKAI, Professor

4-6-1 TEL03-5452-6352


URL: http://envchem.iis.u-tokyo.ac.jp/sakai/index.html

3D human organ engineering for implantation and cell-based assay

Optimization of 3D organization and mass transfer

The general goal of our lab is to optimize 3D cellular organization and good

mass transfer in various scales in vitro based on chemical engineering for

regenerative medicine and cell-based assays. We have also been trying to best

integrate knowledge and technologies from various disciplines in awell-balanced manner to attain that goal.


Process development for mass production and differentiation of stem

cells

Engineering of implantable liver and pancreas beta-cell tissues

Development of advanced cell-based assays for efficacy/hazard

evaluations of drug candidates or environmental chemicals

Taichi ITO, Associate Professor

207 TEL: 03-5841-1698


URL: http://www.cdbim.m.u-tokyo.ac.jp/itolab/


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DDS

Systematic design of biomaterials for tissue engineering and drug

delivery

We aimed the development of novel medical devices based on chemical

engineering and polymer science. Especially we design new hydrogels which

are made from polysaccharides, dendritic polymers, and serum proteins in termsof their nano-sized structure. To bridge the synthesis of materials and their

application, we emphasize system design based on mass transfer and reaction

kinetics. We also make an effort to collaborate with clinical researcher in

hospitals, and educate young researchers who can overview their own research

area.


Development of newin situcross-linkable hydrogels based on

polysaccharides and dendritic polymers

Anti-peritoneal adhesion materials and hemostats

Drug delivery for the treatment of peritoneal dissemination

Oxygen carriers for tissue engineering

Angiogenesis in hydrogels

Documents

141112_guide for Examination