1
Conclusion: Only 65% of the patients suggested commencing CPAP treatment accepted to do so. The average dropout rate was linear and about 5% per year. The acceptance was significantly correlated to ODI. Com- pliance was not higher for patients with ODI > 30, at the 8-year follow-up. doi:10.1016/j.sleep.2006.07.038 135 Prevalence of subjective residual excessive daytime sleepiness in patients correctly treated with continuous positive airway pressure Xua ˆn-Lan Nguyen * , Dominique Rakotonanahary, Joe ¨l Chaskalovic, Carole Philippe, Chantal Hausser-Haw, Bernard Lebeau, Bernard Fleury Universite ´ Pierre et Marie Curie, Service de Pneumologie, Ho ˆ pital Saint-Antoine, Paris, France Objective: This study aimed to assess the prevalence of residual subjective excessive daytime sleepiness (EDS) in patients correctly treated with continuous positive air- way pressure after 12 months of treatment. Design: A prospective follow-up study in a cohort of 219 consecutive Obstructive Sleep Apnea (OSA) patients treated with an auto-titrating device. Setting: Participants spent one night in the sleep labora- tory of an Academic Teaching Hospital and were then followed up in their homes. Measurements and results: In 219 correctly treated patients (oxyhemoglobin desaturation index >3% = 4 ± 2/h), vigilance was regularly assessed, using 4 mea- sures of the Epworth Sleepiness Scale separated by a mean interval of 108 ± 36 days, and compliance provided by the device was obtained. Patients were considered as regular users if their CPAP use was P4 hours/day and P5 days a week. Because in 54/219 (25%) patients, Epworth Sleep- iness scores (ESS) continued to vary, during the follow-up period (433 ± 73 days) patients were considered as som- nolent if the mean score of the 4 ESS was P11. Thirty- four out of 219 (16%) patients remained somnolent (mean ESS = 13 ± 3), including 16 non regular users (compli- ance = 3.00 ± 1.74 h/day during 44 ± 18% of days) and 18 regular users. Among the latter ones, only 4 patients (2%) did not present any recognized pathology associated with somnolence. Conclusion: Residual subjective EDS was rare when using an adequate definition for somnolence and compliance. doi:10.1016/j.sleep.2006.07.039 136 Prediction of uvulopalatopharyngoplasty outcome: Anat- omy-based staging system versus severity-based staging system Hsueh-Yu Li 1,* , Ning-Hung Chen 2 , Tuan-Jen Fang 1 1 Department of Otolaryngology, Sleep Center, Chang Gung Memorial Hospital, Taipei, Taiwan 2 Department of Pulmonary and Critical Care Medicine, Sleep Center, Chang Gung Memorial Hospital, Taipei, Taiwan Study objective: To evaluate and compare outcomes of uvulopalatopharyngoplasty (UPPP) for obstructive sleep apnea/hypopnea syndrome (OSAHS) by using an anatomy-based and a severity-based staging system. Design: Prospective design with retrospective review. Setting: A tertiary care, sleep disorders referral center. Patients: One hundred and ten OSAHS patients (105 men, mean age 43 years, AHI of 44.4 ± 28.8 events/h, body mass index of 27.1 ± 3.3 kg/m 2 ). Measurements: An anatomy-based staging system (stages I–IV) was used to classify OSAHS patients by examining the tongue-palate position, tonsil size, body mass index, and craniofacial deformities. Patients were also classified as ‘‘mild, moderate, moderate-severe or severe’’ based on preoperative apnea/hypopnea index (AHI) from poly- somnography (severity-based staging system). The surgi- cal success was defined as a 50% reduction of AHI and a postoperative AHI less than 20 events/h. Intervention: UPPP surgery. Results: The overall success rate of UPPP was 78%, the success rates in mild (90%), moderate (73%), moderate- severe (81%) and severe (74%) diseases were similar (P = 0.10). To the contrary, the success rates in patients with anatomy-based stages I–IV were 100%, 96%, 65% and 20%, respectively, and were significantly different (P < 0.001). Changes of AHI were significantly correlat- ed with Friedman tongue position (FTP) (r = 0.30, p = 0.0012) and tonsil size (r= 0.42, p < 0.0001). The FTP (odds ratio=0.43, SE = 0.13, p = 0.005, 95% CI 0.24–0.78) and tonsil size (odds ratio = 3.13, SE = 1.53, p = 0.02, 95% CI 1.20–8.17), rather than severity-based stage (odds ratio = 0.77, SE=0.18, p = 0.283, 95% CI 0.49–1.23), were predictive of surgical success. Conclusions: The anatomy-based staging system, rather than severity-based staging system, is more reasonable for the prediction of UPPP outcomes. The anatomy- based staging system can provide better case selection information for patient counseling before UPPP surgery. doi:10.1016/j.sleep.2006.07.040 137 The effect of CPAP on obstructive sleep apnea patients without daytime sleepiness Peilin Lee 1,2,* , Ching-Ting Tang 3 , Bee-Horng Lue 4 , Chong-Ren Yu 4 , Pan-Chyr Yang 4 S16 Abstracts / Sleep Medicine 7 (2006) S1–S127

135 Prevalence of subjective residual excessive daytime sleepiness in patients correctly treated with continuous positive airway pressure

Embed Size (px)

Citation preview

Conclusion: Only 65% of the patients suggestedcommencing CPAP treatment accepted to do so. Theaverage dropout rate was linear and about 5% per year.The acceptance was significantly correlated to ODI. Com-pliance was not higher for patients with ODI > 30, at the8-year follow-up.

doi:10.1016/j.sleep.2006.07.038

135 Prevalence of subjective residual excessive daytime

sleepiness in patients correctly treated with continuous

positive airway pressure

Xuan-Lan Nguyen *, Dominique Rakotonanahary, Joel

Chaskalovic, Carole Philippe, Chantal Hausser-Haw,

Bernard Lebeau, Bernard Fleury

Universite Pierre et Marie Curie, Service de Pneumologie,

Hopital Saint-Antoine, Paris, France

Objective: This study aimed to assess the prevalence ofresidual subjective excessive daytime sleepiness (EDS)in patients correctly treated with continuous positive air-way pressure after 12 months of treatment.Design: A prospective follow-up study in a cohort of 219consecutive Obstructive Sleep Apnea (OSA) patientstreated with an auto-titrating device.Setting: Participants spent one night in the sleep labora-tory of an Academic Teaching Hospital and were thenfollowed up in their homes.Measurements and results: In 219 correctly treatedpatients (oxyhemoglobin desaturation index >3% =4 ± 2/h), vigilance was regularly assessed, using 4 mea-sures of the Epworth Sleepiness Scale separated by a meaninterval of 108 ± 36 days, and compliance provided by thedevice was obtained. Patients were considered as regularusers if their CPAP use was P4 hours/day and P5 daysa week. Because in 54/219 (25%) patients, Epworth Sleep-iness scores (ESS) continued to vary, during the follow-upperiod (433 ± 73 days) patients were considered as som-nolent if the mean score of the 4 ESS was P11. Thirty-four out of 219 (16%) patients remained somnolent (meanESS = 13 ± 3), including 16 non regular users (compli-ance = 3.00 ± 1.74 h/day during 44 ± 18% of days) and18 regular users. Among the latter ones, only 4 patients(2%) did not present any recognized pathology associatedwith somnolence.Conclusion: Residual subjective EDS was rare when usingan adequate definition for somnolence and compliance.

doi:10.1016/j.sleep.2006.07.039

136 Prediction of uvulopalatopharyngoplasty outcome: Anat-

omy-based staging system versus severity-based staging system

Hsueh-Yu Li 1,*, Ning-Hung Chen 2, Tuan-Jen Fang 1

1 Department of Otolaryngology, Sleep Center, Chang

Gung Memorial Hospital, Taipei, Taiwan2 Department of Pulmonary and Critical Care Medicine,

Sleep Center, Chang Gung Memorial Hospital, Taipei,

Taiwan

Study objective: To evaluate and compare outcomes ofuvulopalatopharyngoplasty (UPPP) for obstructivesleep apnea/hypopnea syndrome (OSAHS) by usingan anatomy-based and a severity-based stagingsystem.Design: Prospective design with retrospective review.Setting: A tertiary care, sleep disorders referral center.Patients: One hundred and ten OSAHS patients (105men, mean age 43 years, AHI of 44.4 ± 28.8 events/h,body mass index of 27.1 ± 3.3 kg/m2).Measurements: An anatomy-based staging system (stagesI–IV) was used to classify OSAHS patients by examiningthe tongue-palate position, tonsil size, body mass index,and craniofacial deformities. Patients were also classifiedas ‘‘mild, moderate, moderate-severe or severe’’ based onpreoperative apnea/hypopnea index (AHI) from poly-somnography (severity-based staging system). The surgi-cal success was defined as a 50% reduction of AHI and apostoperative AHI less than 20 events/h.Intervention: UPPP surgery.Results: The overall success rate of UPPP was 78%, thesuccess rates in mild (90%), moderate (73%), moderate-severe (81%) and severe (74%) diseases were similar(P = 0.10). To the contrary, the success rates in patientswith anatomy-based stages I–IV were 100%, 96%, 65%and 20%, respectively, and were significantly different(P < 0.001). Changes of AHI were significantly correlat-ed with Friedman tongue position (FTP) (r = �0.30,p = 0.0012) and tonsil size (r=�0.42, p < 0.0001). TheFTP (odds ratio=0.43, SE = 0.13, p = 0.005, 95% CI0.24–0.78) and tonsil size (odds ratio = 3.13,SE = 1.53, p = 0.02, 95% CI 1.20–8.17), rather thanseverity-based stage (odds ratio = 0.77, SE=0.18,p = 0.283, 95% CI 0.49–1.23), were predictive of surgicalsuccess.Conclusions: The anatomy-based staging system, ratherthan severity-based staging system, is more reasonablefor the prediction of UPPP outcomes. The anatomy-based staging system can provide better case selectioninformation for patient counseling before UPPPsurgery.

doi:10.1016/j.sleep.2006.07.040

137 The effect of CPAP on obstructive sleep apnea

patients without daytime sleepiness

Peilin Lee 1,2,*, Ching-Ting Tang 3, Bee-Horng Lue 4,

Chong-Ren Yu 4, Pan-Chyr Yang 4

S16 Abstracts / Sleep Medicine 7 (2006) S1–S127