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A mutation in a gene critical to normal heart development could play a role in some types of congenital heart disease, which is the most common birth defect in the U.S., affecting as many as 40,000 newborns a year.

Researchers Identify Genetic Mutation Linked to Congenital Heart Disease

THE HEART CENTER

Cardiac ICU discharges:

576

Total clinic visits:

13,112

Total Inpatient discharges:

1,094

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Chang SW, Mislankar M, Misra C, Huang N, Dajusta DG, Harrison SM, McBride KL, Baker LA, Garg V. Genetic abnormalities in FOXP1 are associated with congenital heart defects. Human Mutation. 2013 Sep;34(9):1226-30. PMID: 23766104.

A mutation in a gene critical to normal heart development could play a role in some types of congenital heart disease, which is the most common birth defect in the U.S., affecting as many as 40,000 newborns a year. This finding, published in the journal Human Mutation, could help narrow the search for genes that contribute to congenital heart defects, since several hundred genes have been implicated in the formation of the heart and a mutation in any of them could potentially contribute to a heart defect.

Identifying which of these genes is involved in human congenital heart disease has been a challenge for scientists in the field, says Vidu Garg, MD, senior author of the study and director of Translational Research in The Heart Center at Nationwide Children’s Hospital.

After a former colleague called about an infant who had a complex congenital heart disease and a rare genetic abnormality in the FOXP1 gene, Dr. Garg decided to take a closer look at the gene. A few studies on FOXP1, a member of a large gene family that helps regulate tissues throughout the body, had described its function and role in cardiac development in animal models.

Dr. Garg and his team conducted a search of DNA samples from patients with congenital heart disease in a repository at Nationwide

Children’s – one of the largest in the nation. They found two additional patients with a similar complex heart defect were found to have a rare mutation in the same gene. On further analysis, Dr. Garg’s team found that this mutation affected the gene’s ability to express a transcription factor called Nkx2.5, which has been implicated in congenital heart disease.

“If you have three unrelated people with an abnormality in the same gene, and they also have an extremely rare type of congenital heart disease, there’s a high likelihood that the gene is contributing to the condition,” says Dr. Garg, who also is a principal investigator in the Center for Cardiovascular and Pulmonary Research. “Understanding how either deletion or loss of FOXP1 affects normal heart development could help contribute to our understanding of congenital heart disease.”

The next step in the research is to see if they can find the FOXP1 mutation in patients with different types of congenital heart disease. From there, they will begin to look at how the gene interacts with others involved in the formation of a normal heart. Given that congenital heart disease is probably the result of mutations in many genes, Dr. Garg says, it’s quite possible that by studying this gene and its potential partners, we can uncover other potential candidate genes for heart malformations.

THE HEART CENTER

Researchers Identify Genetic Mutation Linked to Congenital Heart Disease

Dr. Vidu Garg

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Department, Section, and Program Reports

THE HEART CENTERThe Heart Center at Nationwide Children’s Hospital combines all clinical and research disciplines under one umbrella in order to meet our mission. We are out in front by discovering the causes of heart disease and developing the therapies of the future for our patients by focusing on them one at a time and providing state-of-the-art care that all patients deserve, regardless of age. We support Nationwide Children’s mission to provide our services in a safe environment.

STAFF PHYSICIANS AND FACULTYTimothy F. Feltes, MDCo-DirectorChief, Pediatric CardiologyProfessor of Clinical Pediatrics

Mark E. Galantowicz, MDCo-DirectorChief, Cardiothoracic SurgeryProfessor of Clinical Surgery

John P. Cheatham, MDCo-DirectorDirector, Cardiac Catheterization and Interventional TherapyProfessor of Pediatrics and Internal Medicine, Cardiology Division

FULL-TIME NCH FACULTY

Carl H. Backes, MDAssistant Professor of Clinical Pediatrics

Jessica L. Bowman, MDAssistant Professor of Clinical Pediatrics

Steven C. Cassidy, MDAssociate Professor of Pediatrics

Marco Corridore, MDClinical Assistant Professor of Anesthesiology

Linda H. Cripe, MDProfessor of Clinical Pediatrics

Clifford L. Cua, MDAssociate Professor of Clinical Pediatrics

Curt J. Daniels, MDProfessor of ClinicalCardiovascular Medicine

Richard P. Fernandez, MDAssistant Professor of Clinical Pediatrics

Jill A. Fitch, MDClinical Associate Professor of Pediatrics

Vidu Garg, MDAssociate Professor of Pediatrics

Don Hayes, MD, MS, MEdAssociate Professor of Clinical Pediatrics

Timothy M. Hoffman, MDProfessor of Clinical Pediatrics

Ralf J. Holzer, MD, MScAssociate Professor of Clinical Pediatrics

Kan N. Hor, MDAssociate Professor of Clinical Pediatrics

Brian F. Joy, MDAssistant Professor of Clinical Pediatrics

Naomi J. Kertesz, MDProfessor of Clinical Pediatrics

Omar M. Khalid, MDAssistant Professor of Clinical Pediatrics

Sara Khan, MDClinical Assistant Professor of Anesthesiology

John P. Kovalchin, MDProfessor of Pediatrics

Anthony Lee, MDClinical Assistant Professor of Pediatrics

Eric Lloyd, MDAssistant Professor of Clinical Pediatrics

Patrick I. McConnell, MDAssistant Professor of Surgery

Christopher T. McKee, DOClinical Assistant Professor of Pediatrics

Katherine M. Mizelle, MDClinical Associate Professor of Pediatrics

Aymen N. Naguib, MDClinical Assistant Professor of Anesthesiology

Christina M. Phelps, MDAssistant Professor of Clinical Pediatrics

Sharon L. Roble, MDAssistant Professor of ClinicalCardiovascular Medicine

Kerry L. Rosen, MDAssociate Professor of Clinical Pediatrics

Daniel G. Rowland, MDAssociate Professor of Clinical Pediatrics

Toshiharu Shinoka, MD, PhDProfessor of Surgery

Janet M. Simsic, MDAssociate Professor of Clinical Pediatrics

Douglas W. Teske, MDAssistant Professor of Pediatrics

Karen M. Texter, MDAssistant Professor of Clinical Pediatrics

Philip T. Thrush, MDAssistant Professor of Clinical Pediatrics

Joseph D. Tobias, MDProfessor of Anesthesiology and Pediatrics

John J. Wheller, MDAssistant Professor of Pediatrics

Peter D. Winch, MD, MBAClinical Assistant Professor of Anesthesiology

Andrew R. Yates, MDAssistant Professor of Clinical Pediatrics

Ali Zaidi, MDAssistant Professor of Clinical PediatricsCenter for Cardiovascular and Pulmonary Research

CENTER FOR CARDIOVASCULAR AND PULMONARY RESEARCHPamela A. Lucchesi, PhDCenter DirectorProfessor of Pediatrics

Christopher K. Breuer, MD

Mary Cismowski, PhDResearch Associate Professor of Pediatrics

Vidu Garg, MDAssociate Professor of Pediatrics

Chetan P. Hans, PhDAssistant Professor of Pediatrics

Tondi M. Harrison, PhD, RN, CPNPAssistant Professor of Pediatrics

Brenda Lilly, PhDAssociate Professor of Pediatrics

Joy Lincoln, PhDAssociate Professor of Pediatrics

Kim L. McBride, MD, MSAssistant Professor of Pediatrics

Patrick I. McConnell, MDAssistant Professor of Surgery

Aaron J. Trask, PhDAssistant Professor of Pediatrics

NATIONAL AND INTERNATIONAL REPUTATIONThe Heart Center is a nationally and internationally recognized comprehensive center for patient care, education, and research. Recognition is demonstrated by the following:

• Ranking #10 for Heart and Heart Surgery Program in U.S.News & World Report, 2013-14

• OptumHealth Center of Excellence designation for CHD and Access Network for Pediatric Heart Transplant

• CIGNA LifeSOURCE Transplant Network for Pediatric Heart Transplant

• Aetna Institute of Excellence in Pediatric Congenital Heart Surgery

• Creating the world’s first Hybrid Cardiac Catheterization Suites and first Hybrid Congenital Cardiac Operating Room in the nation

• One of the first children’s hospitals in the nation to utilize 3D Video Assisted Thorascopy

OUR SERVICESComprehensive clinical care of our patients throughout life is our goal. Our highly qualified team provides state-of-the-art care in areas of diagnostic imaging, noninvasive diagnostics, interventional cardiology, electrophysiology interventions, anesthesiology, nursing, and thoracic surgery including heart, lung, and heart/lung transplan-tation. Our Adult Congenital Heart Disease Program is one of the largest in North America and leads the U.S. in centers with an annual growth of 30 percent. Our outpatient cardiology provides our cardiology services at centers convenient for our patients and their families at 11 regional sites. A substantial portion of our patients come from regions well beyond the traditional primary service area for Nationwide Children’s. In 2012, we had 93 national and international surgical and interventional referrals to The Heart Center.

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QUALITY, SAFETY, SERVICE

The Heart Center leadership team is involved in top-down review for programmatic improvement. Patient quality care and safety issues are defined, measured, and monitored within each of the surgical, medical, and nursing aspects of The Heart Center. We are also involved in external quality review such as state and national quality initiatives related to surgical and catheterization/intervention outcomes. Other involvement includes:

• Society of Thoracic Surgeons (STS) Congenital Heart Surgery Database

• Congenital Heart Surgeons’ Society data center• Joint Council on Congenital Heart Disease

(JCCHD) that is a sponsored collaborative for quality improvement through The Center for Health Care Quality

• Adult Congenital Heart Association – Alliance for Adult Research in Congenital Cardiology (AARCC) collaborative sponsored by the NIH (RO3HL096135) to assess education and access-to-care issues for adults with congenital heart disease

• The Ohio Doctor’s Interested in Congenital Hearts (ODICH) reporting of all Ohio pediatric cardiology centers of data related to surgical and catheterization/intervention outcomes

• Pediatric Heart Transplant Study Group, Ohio Solid Organ Transplant Consortium

• Interventional cardiology participation in the IMPACT registry (Improving Pediatric and Adult Congenital Treatment), C3PO (Congenital Cardiac Catheterization Outcomes Project, one of eight participating centers and MAGIC registries, Congenital Cardiovascular Interventional Study Consortium [CCISC])

• American College of Cardiology, Adult Congenital and Pediatric Cardiology Section– noninvasive imaging, adult congenital heart disease, ambulatory cardiology quality metrics work groups

• American College of Cardiology – Adult Congenital and Pediatric Cardiology Committee Council members

• National Pediatric Cardiology-Quality Improvement Collaborative (NPC-QIC)

• Virtual pediatric ICU system• National Cardiovascular Disease Registry -

Internal Cardioverter Defibrillator (NCDR-ICD)

EDUCATION

The Heart Center’s ACGME fellowship program offers a well-rounded experience in pediatric/congenital cardiology. We offer both a traditional Pediatric Cardiology Fellowship and a five-year Pediatric/Adult Cardiology Fellowship that is recognized by both the American Board of Internal Medicine and the American Board of Pediatrics. We have nine fellows and 100% of fellows with more than 1.5 years of training are presenting at national/regional peer-reviewed meetings.

RESEARCH

Investigators in the Center for Cardiovascular and Pulmonary Research, located in The Research Institute at Nationwide Children’s, collaborate closely with clinicians from The Heart Center.

The center awards peer-reviewed intramural pilot projects to enhance clinician-initiated research. The success of this investment has resulted in extramural funding increasing eightfold from 2007 to 2012, totaling $2.3 million.

The centers recently received a National Institutes of Health Institutional T32 training grant renewal for MD and PhD fellows that is the first in the U.S. to focus on acquired and congenital heart disease that spans fetal life through senescence. This program provides 15 training slots through 2014. In addition, basic and physician-scientists continue to conduct innovative, mechanism-based research leading to improved therapies and outcomes for pediatric cardiovascular diseases. One aim is to foster preventive strategies and promote cardiovascular health in adults by altering risk factors during childhood.

Clinical/translational research initiatives include examining the effect of maternal caregiving on stress neurobiology in full-term infants with congenital heart defects, and examining whether timing of umbilical cord clamping among infants with prenatal diagnosis of congenital heart disease can positively affect clinical outcomes.

Current basic research includes investigating signaling cascades that regulate cardiovascular remodeling and function during disease progression, the genetic basis of congenital heart defects, molecular pathways regulating normal and abnormal cardiac development, and regulatory pathways that control vascular development and smooth muscle differentiation.

RESEARCH FUNDING (OVER $50,000) AWARDED JULY 2013 - JUNE 2014 Daniels, Curt A Double-Blind Efficacy and Safety Study of the Phosphodiesterase Type 5 Inhibitor Study Drug in Pediatric Patients With Pulmonary Arterial Hypertension Industry Sponsor $134,131

Garg, Vidu Notch Signaling and Ascending Aortic Aneurysm Saving Tiny Hearts Society $50,000

Hans, Chetan Role of Notch1 Signaling in Abdominal Aortic Aneurysm – SDG American Heart Association – National $77,000

Lewis, Kristin PhD Dissertation Research Training American College of Veterinary Pathologists and Society of Toxicologic Pathology Coalition for Veterinary Pathology Fellows Genentech $73,524

Lilly, Brenda Role of Notch Signaling in Vascular Development and Function American Heart Association - National $77,000

Lincoln, Joy The Role of Sox9 in Calcific Aortic Valve Disease American Heart Association - National $77,000

Lucchesi, Pam Training in Congenital and Acquired Heart Disease National Institutes of Health (NIH) National Heart, Lung, and Blood Institute (NHLBI) $274,302

McBride, Kim Exome Sequencing and Functional Studies in Familial CHD NIH NHLBI $669,080

Trask, Aaron Differential Macro- and Micro-Vascular Remodeling in Type 2 Diabetes and Metabolic Syndrome NIH NHLBI $129,060

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Chang WE, Mislankar M, Misra C, Huang N, Dajusta DG, Harrison SM, McBride KL, Baker LA, Garg V. “Genetic abnormalities in FOXP1 are associated with congenital heart defects.” Human Mutation. Vol. 34, No.9 (2013): 1226 – 30.

Cotts T, Khairy P, Opotowsky AR, John AS, Valente AM, Zaidi AN, Cook SC, Aboulhosn J, Ting JG, Gurvitz M, Landzberg MJ, Verstappen A, Kay J, Earing M, Franklin W, Kogon B, Broberg CS; for the Alliance for Adult Research in Congenital Cardiology (AARCC). “Clinical research priorities in adult congenital heart disease.” International Journal of Cardiology. [Epub 2013 Dec 24].

Cripe LH, Tobias JD. “Cardiac considerations in the operative management of the patient with Duchenne or Becker muscular dystrophy.” Paediatric Anaesthesia. [Epub 2013 Jul 19].

Cua CL, Kollins K, McConnell PI. “Echocardiographic analysis of an extracellular matrix tricuspid valve.” Echocardiography. [Epub 2014 Jun 11].

Delbin MA, Trask AJ. “The diabetic vasculature: physiological mechanisms of dysfunction and influence of aerobic exercise training in animal models.” Life Sciences. [Epub 2014 Feb 27].

Dion JM, McKee C, Tobias JD, Herz D, Sohner P, Teich S, Michalsky M. “Carbon dioxide monitoring during laparoscopic-assisted bariatric surgery in severely obese patients: transcutaneous versus end-tidal techniques.” Journal of Clinical Monitoring and Computing. [Epub 2014 Jun 11].

El-Said HG, Bratincsak A, Foerster SR, Murphy JJ, Vincent J, Holzer R, Porras D, Moore J, Bergersen L. “Safety of percutaneous patent ductus arteriosus closure: an unselected multicenter population experience.” Journal of the American Heart Assocociation. Vol. 2, No.6 (2013): e000424.

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Foy PM, Wheller JJ, Samuels P, Evans KD. “Evaluation of the fetal heart at 14 to 18 weeks’ gestation in fetuses with a screening nuchal translucency greater than or equal to the 95th percentile.” Journal of Ultrasound in Medicine. Vol. 32, No.10 (2013): 1713 – 9.

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Garg V, Basu M. “Beyond genetics: focusing on maternal environment for congenital heart disease prevention.” Evidence-Based Medicine. [Epub 2013 Nov 26].

Giglia TM, Massicotte MP, Tweddel JS, Barst Rj, Bauman M, Erickson CC, Feltes TF, Foster E, Hinoki K, Ichord RN, Kreutzer J, McCrindle BW, Newburger JW, Tabbutt S, Todd JL, Webb CL; on behalf of the American Heart Association Congenital Heart Defects Committee of the Council on Cardiovascular Disease in the Young, Council on Cardiovascular and Stroke Nursing, Council on Epidemiology and Prevention, and Stroke Council. “Prevention and treatment of thrombosis in pediatric and congenital heart disease: a scientific statement from the American Heart Association.” Circulation. [Epub 2013 Nov 13].

Harrison TM. “Autonomic nervous system function, child behavior, and maternal sensitivity in three-year-old children with surgically corrected transposition.” Heart & Lung: The Journal of Critical Care. [Epub 2013 Sep 12].

Hayes D Jr., Baker PB, Kopp BT, Kirkby S, Galantowicz M, McConnell PI, Astor TL. “Surveillance transbroncial biopsies in infant lung and heart-lung transplant recipents.” Pediatric Transplantation. [Epub 2013 Aug 21].

Hayes D Jr., Daniels CJ, Kirkby S, Kopp BT, Nicholson KL, Nance AE, Splaingard ML. “Polysomnographic differences associated with pulmonary hypertension in patients with advanced lung disease due to cystic fibrosis.” Lung. [Epub 2014 Mar 27].

Hayes D Jr., Daniels CJ, Mansour HM, Kopp BT, Yates AR, McCoy KS, Patel AV, Kirkby S. “Right heart catheterization measuring central hemodynamics in cycstic fibrosis during exercise.” Respiratory Medicine. [Epub 2013 Jul 2].

Hayes D Jr., Galantowicz M, Preston TJ, Lloyd EA, Tobias JD, McConnell PI. “Tracheostomy in adolescent patients bridged to lung transplantation with ambulatory venovenous extracorporeal membrane oxygenation.” Journal of Artificial Organs. [Epub 2013 Nov 13].

Hayes D Jr., Kirkby S, Wehr AM, Lehman AM, McConnell PI, Galantowicz M, Higgins RS, Whitson BA. “A contemporary analysis of induction immunosuppression in pediatric lung transplant recipients.” Transplant International. [Epub 2013 Nov 15].

Hayes D Jr., McConnell PI, Preston TJ, Nicol KK. “Hyperbilirubinemia complicating plasma-free hemoglobin and antifactor xa level monitoring on venovenous extracorporeal membrane oxygenation.” World Journal for Pediatric & Congenital Heart Surgery. Vol. 5, No.2 (2014): 345 – 7.

Hayes D Jr., McConnell PI, Preston TJ, Yates AR, Kirkby S, Galantowicz M. “Active rehabilitation with venovenous extracorporeal membrane oxygenation as a bridge to lung transplantation in a pediatric patient.” World Journal of Pediatrics: WJP. Vol. 9, No.4 (2013): 373 – 4.

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Hayes D Jr., Tobias JD, Galantowicz M, Preston TJ, Tzemos KK, McConnell PI. “Video fluoroscopy swallow study and nutritional support during ambulatory venovenous extracorporeal membrane oxygenation as a bridge to lung transplantation.” World Journal for Pediatric & Congenital Heart Surgery. Vol. 5, No.1 (2014): 91 – 3.

Hayes D Jr., Tobias JD, Kukreja J, Preston TJ, Yates AR, Kirkby S, Whitson BA. “Extracorporeal life support for acute respiratory distress syndromes.” Annals of Thoracic Medicine. Vol. 8, No.3 (2013): 133 – 41.

Hayes D, Yates AR, Duffy VL, Tobias JD, Mansour HM, Olshove VF, Preston TJ. “Rapid placement of bicaval dual-lumen catheter in a swine model of venovenous ECMO.” Journal of Investigative Surgery. [Epub 2013 Aug 26].

Hodge AB, Preston TJ, Fitch JA, Harrison SK, Hersey DK, Nicol KK, Naguib AN, McConnell PI, Galantowicz M. “Quality improvement methodologies increase autologous blood product administration.” The Journal of Extra-Corporeal Technology. Vol. 46, No.1 (2014): 45 – 52.

Hor KN, Taylor MD, Al-Khalidi HR, Cripe LH, Raman SV, Jefferies JL, O Donnell R, Benson DW, Mazur W. “Prevalence and distribution of late gadolinium enhancement in a large population of patients with Duchenne muscular dystrophy: effect of age and left ventricular systolic function.” Journal of Cardiovascular Magnetic Resonance. Vol. 15, No.1 (2013): 107.

Husain N, Gokhale J, Nicholson L, Cheatham JP, Holzer RJ, Cua CL. “Noninvasive estimation of ventricular filling pressures in patients with single right ventricles.” Journal of The American Society of Echocardiography. [Epub 2013 Sep 12].

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Khairy P, Van Hare GF, Balaji S, Berul CI, Cecchin F, Cohen MI, Daniels CJ, Deal BJ, Dearani JA, Groot ND, Dubin AM, Harris L, Janousek J, Kanter RK, Karpawich PP, Perry JC, Seslar SP, Shah MJ, Silka MJ, Triedman JK, Walsh EP, Warnes CA. “PACES/HRS expert consensus statement on the recognition and management of arrhythmias in adult congenital heart disease.” Heart Rhythm. [Epub 2014 May 7].

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Lawless CE, Olshansky B, Washington RL, Baggish AL, Daniels CJ, Lawrence SM, Sullivan RM, Kovacs RJ, Bove AA. “Sports and exercise cardiology in the United States: cardiovascular specialists as members of the athlete healthcare team.” Journal of the American College of Cardiology. [Epub 2014 Jan 31].

Lee N, Das A, Taylor M, Hor K, Banerjee RK. “Energy transfer ratio as a metric of right ventricular efficiency in repaired congenital heart disease.” Congenital Heart Disease. Vol. 8, No.4 (2013): 328 – 42.

Lee N, Taylor MD, Hor KN, Banerjee RK. “Non-invasive evaluation of energy loss in the pulmonary arteries using 4D phase contrast MR measurement: a proof of concept.” Biomedical Engineering Online. Vol. 12, No.1 (2013): 93.

Lee YU, Yi T, Tara S. Lee AY, Hibino N, Shinoka T, Breuer CK. “Implantation of inferior vena cava interposition graft in mouse model.” Journal of Visualized Experiments : JoVE. No.88 (2014). doi: 10.3791/51632.

Lin CH, Hedge S, Marshall AC, Porras D, Gauvreau K, Balzer DT, Beekman RH 3rd, Torres A, Vincent JA, Moore JW, Holzer R, Armsby L, Bergersen L. “Incidence and management of life-threatening adverse events during cardiac catheterization for congenital heart disease.” Pediatric Cardiology. [Epub 2013 Jul 31].

Lin CH, Lilly B. “Endothelial cells direct mesenchymal stem cells toward a smooth muscle cell fate.” Stem Cells and Development. [Epub 2014 Jun 10].

Madueme PC, Mazur W, Hor KN, Germann JT, Jefferies JL, Taylor MD. “Comparison of area-length by echocardiography versus full-volume quantification by cardiac magnetic resonance imaging for the assessment of left atrial volumes in children, adolescents, and young adults.” Pediatric Cardiology. [Epub 2013 Nov 17].

Meadows JJ, Moore PM, Berman DP, Cheatham JP, Cheatham SL, Porras D, Gillespie MJ, Rome JJ, Zahn EM, McElhinney DB. “Use and performance of the melody transcatheter pulmonary valve in native and postsurgical, nonconduit right ventricular outflow tracts.” Circulation. Cardiovascular Interventions. [Epub 2014 May 27].

Misra C, Chang SW, Basu M, Huang N, Garg V. “Disruption of myocardial Gata4 and Tbx5 results in defects in cardiomyocyte proliferation and atrioventricular septation.” Human Molecular Genetics. [Epub 2014 May 8].

Mitchell E, Cheatham JP, Sisk JM, Nicholson L, Holzer R, Galantowicz M, Cua CL. “Neutrophil/lymphocyte ratio and association with arch intervention in patients with hypoplastic left heart syndrome undergoing hybrid procedure.” Congenital Heart Disease. [Epub 2014 Apr 4].

Morray BH, EcElhinney DB, Cheatham JP, Zahn EM, Berman DP, Sullivan PM, Lock JE, Jones TK. “Risk of coronary artery compression among patients referred to transcatheter pulmonary valve implantation: a multicenter experience.” Circulation. Cardiovascular Interventions. [Epub 2013 Sep 24].

Motawea HK, Jeyaraj SC, Eid AH, Mitra S, Unger NT, Ahmed AA, Flavahan NA, Chotani MA. “Cyclic AMP-Rap1A signaling mediates cell surface translocation of microvascular smooth muscle α2C-adrenoceptors through the actin-binding protein filamin-2.” American Journal of Physiology. Cell Physiology. Vol. 305, No.8 (2013): C829 – 45.

Murrey DA, Naughton BJ, Duncan FJ, Meadows AS, Ware TA, Campbell K, Bremer WG, Walker C, Goodchild L, Bolon B, La Perle K, Flanigan K, McBride KL, McCarty DM, Fu H. “Feasibility and safety of systemic rAAV9-hNAGLU delivery for treating MPS IIB: toxicology, bio-distribution and immunological assessments in primates.” Human Gene Therapy. Clinical Development. [Epub 2014 Mar 11].

Naito Y, Lee YU, Yi T, Church SN, Solomon D, Humphry JD, Shinoka T, Breuer CK. “Beyond burst pressure: initial evaluation of the natural history of the biaxial mechanical properties of tissue engineered vascular grafts in the venous circulation using a murine model.” Tissue Engineering. Part A. [Epub 2013 Aug 19].

Naito Y, Rocco K, Kurobe H, Maxfield M, Breuer C, Shinoka T. “Tissue engineering in the vasculature.” Anatomical Record (Hoboken, N.J.: 2007). [Epub 2013 Dec 2].

Noel CV, Kovalchin JP, Adler B, Yates AR. “Incidence of tracheobronchial anomalies found with hypoplastic left heart syndrome.” Congenital Heart Disease. [Epub 2013 Sep 19].

Pignatelli RH, Texter KM, Denfield SW, Grenier MA, Altman CA, Ayres NA, Chandra-Bose Reddy S. “LV noncompaction in Ebstein’s anomly in infants and outcomes.” JACC. Cardiovascular Imaging. Vol. 7, No.2 (2014): 207 – 9.

Mendell JR, Rodino-Klapac LR, Sahenk Z, Roush K, Bird L, Lowes LP, Alfano L, Gomez AM, Lewis S, Kota J, Malik V, Shontz K, Walker CM, Flanigan KM, Corridore M, Kean JR, Allen HD, Shilling C, Melia Kr, Sazani P, Saoud JB, Kaye EM; the Eteplirsen Study Group. “Eteplirsen for the treatment of Duchenne muscular dystrophy.” Annals of Neurology. [Epub 2013 Sep 10].

Rogers LK, Lucchesi PA. “Stress adaptation and the resilience of youth: fact or fiction?” Physiology (Bethesda). Vol. 29, No.3 (2014): 156.

Simsic JM, Harrison S, Evans L, McClead R, Teske D. “Reducing variation in the use of inhaled nitric oxide.” Pediatrics. [Epub 2014 May 12].

Stacy MR, Naito Y, Maxfield MW, Kurobe H, Tara S, Chan C, Rocco KA, Shinoka T, Sinusas AJ, Breuer CK. “Targeted imaging of matrix metalloproteinase activity in the evaluation of remodeling tissue-engineered vascular grafts implanted in a growing lamb model.” The Journal of Thoracic and Cardiovascular Surgery. [Epub 2014 May 21].

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Tandon A, Taylor MD, Cripe LH. “Co-occurring Duchenne muscular dystrophy and hypertrophic cardiomyopathy in an adult with atypical cardiac phenotype.” Cardiology in the Young. [Epub 2014 Jan 29:1-3].

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Webb G, Landzberg MJ, Daniels CJ. “Specialized adult congenital heart care saves lives.” Circulation. [Epub 2014 Mar 3].

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Williams RV, Margossian R, Lu M, Atz AM, Bradley TJ, Jay Campbell M, Colan SD, Gallagher D, Lai WW, Pearson GD, Prakash A, Shirali G, Cohen MS; Pediatric Heart Network Investigators. “Factors impacting echocardiographic imaging after the fontan procedure; a report for the pediatric heart network fontan cross-sectional study.” Echocardiography. Vol. 30, No.9 (2013): 1098 – 106.

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Yates AR, Duffy VL, Clark TD, Hayes D Jr., Tobias JD, McConnell PI, Preston TJ. “Cardiac tamponade: new technology masking an old NEMISIS.” The Annals of Thoracic Surgery. Vol. 97, No.3 (2014): 1046 – 8.

FAST FACTSJuly 2013 – June 2014

Heart Center Inpatient/ObservationInpatient Discharges: 634Observation and Outpatient-in-a-Bed Discharges: 460Total Discharges: 1,094Average Length of Stay*: 9.7Average Daily Census*: 16.9Total Patient Days*: 6,181*Excludes observation and outpatient-in-a-bed cases.

Cardiac ICUInpatient Discharges: 576Average Length of Stay*: 6.5Average Daily Census*: 10.2Total Patient Days*: 3,729

*Excludes observation and outpatient-in-a-bed cases.

Ashland KY Cardiology Clinic Visits: 40Athens Cardiology Clinic Visits: 70Cardiology Clinic Visits: 9,109Cardiothoracic Surgery Clinic Visits 289Chillicothe Cardiology Clinic Visits: 164Dayton Cardiology (PAA) Clinic Visits: 199Dublin Cardiology Clinic Visits: 1,199East Broad Cardiology Clinic Visits: 185Findlay Cardiology Clinic Visits: 73Ironton Cardiology Clinic Visits: 85Kawasaki Clinic Visits: 122Lima Cardiology (PAA) Clinic Visits: 531Mansfield Cardiology Clinic Visits: 189Marietta Cardiology Clinic Visits: 139Marion Cardiology Clinic Visits: 160Portsmouth Cardiology Clinic Visits: 78Westerville Cardiology Clinic Visits: 243Zanesville Cardiology Clinic Visits: 237Total Cardiology Clinic Visits: 13,112