1.Author Academy:Steps to Publication SuccessDe La Salle University 1 March 2013 Jeff Robens, PhDSenior Editor

2. About Jeff Researcher Teacher MentorAuthor Peer reviewerSenior Editor 3. Todays presentation Reading strategies Abstracts Manuscript structure Increasing readability 4. Section 1Reading Strategies 5. Reading StrategiesReading improvesmanuscript writingRead often!Learn how nativeLearn manuscript Article and journalEnglish speakers write structure and style qualityLearn proper Get new ideas, argument structureidentify knowledge gapsDiscuss with colleagues 6. Reading Strategies Make time to read Most researchers read 6090 min per daySpend 2030 min every day reading abstracts Spend 60 min 2 or 3 days a week reading papersJoin a journal club 7. Reading Strategies How to read an article FromSectionstart to byfinish? section? Not efficient! What do you Where can youwant to know?find it? 8. Reading Strategies Strategies for reading Read Title and Abstract first Self-assess knowledge of topic Read last paragraph of introduction for hypothesis/objectives Read Figures and then Results Read Discussion for interpretationRefer to Introduction andMethods if necessary 9. Section 2Abstracts 10. Abstracts Important points Relevance of Importance ofValidity of youryour aimsyour results conclusionsFirst impression of your paperJudge yourProbably only partwriting stylethat will be read 11. Abstracts General GuideBackground Why the study was done (20%) AimsYour hypothesis (10%) MethodsTechniques (10%) Results Most important findings (40%)Conclusion Conclusion & implications (20%) 12. Abstracts Structured abstract medical and clinicalImmunotherapy using slow-cycling tumor cells prolonged overall survival of tumor-bearing miceBackgroundDespite considerable progress in the development of anticancer therapies, there is still a high mortality rate caused by cancerrelapse and metastasis. Dormant or slow-cycling residual tumor cells are thought to be a source of tumor relapse and metastasis,and are therefore an obstacle to therapy. In this study, we assessed the drug resistance of tumor cells in mice, and investigatedwhether vaccination could promote survival.MethodsThe mouse colon carcinoma cell line CT-26 was treated with 5-fluorouracil to assess its sensitivity to drug treatment. Mice withcolon tumors were immunized with inactivated slow-cycling CT-26 cells to estimate the efficacy of this vaccine.ResultsWe identified a small population of slow-cycling tumor cells in the mouse colon carcinoma CT-26 cell line, which was resistant toconventional chemotherapy. To inhibit tumor recurrence and metastasis more effectively, treatments that selectively target theslow-cycling tumor cells should be developed to complement conventional therapies. We found that drug-treated, slow-cyclingtumor cells induced a more intense immune response in vitro. Moreover, vaccination with inactivated slow-cycling tumor cellscaused a reduction in tumor volume and prolonged the overall survival of tumor-bearing mice.ConclusionsThese findings suggest that targeting of slow-cycling tumor cells application using immunotherapy is a possible treatment tocomplement traditional antitumor therapy.Sun et al. (2012). BMC Medicine 10:172. 13. Abstracts Structured abstract medical and clinicalImmunotherapy using slow-cycling tumor cells prolonged overall survival of tumor-bearing miceBackgroundDespite considerable progress in the development of anticancer therapies, there is still a high mortality rate caused by cancerrelapse and metastasis. Dormant or slow-cycling residual tumor cells are thought to be a source of tumor relapse and metastasis,and are therefore an obstacle to therapy. In this study, we assessed the drug resistance of tumor cells in mice, and investigatedwhether vaccination could promote survival.MethodsThe mouse colon carcinoma cell line CT-26 was treated with 5-fluorouracil to assess its sensitivity to drug treatment. Mice withcolon tumors were immunized with inactivated slow-cycling CT-26 cells to estimate the efficacy of this vaccine.ResultsWe identified a small population of slow-cycling tumor cells in the mouse colon carcinoma CT-26 cell line, which was resistant toconventional chemotherapy. To inhibit tumor recurrence and metastasis more effectively, treatments that selectively target theslow-cycling tumor cells should be developed to complement conventional therapies. We found that drug-treated, slow-cyclingtumor cells induced a more intense immune response in vitro. Moreover, vaccination with inactivated slow-cycling tumor cellscaused a reduction in tumor volume and prolonged the overall survival of tumor-bearing mice.ConclusionsThese findings suggest that targeting of slow-cycling tumor cells application using immunotherapy is a possible treatment tocomplement traditional antitumor therapy.Sun et al. (2012). BMC Medicine 10:172. 14. AbstractsUnstructured abstractDifferential DNA Methylation Status Between HumanPreadipocytes and Mature Adipocytes Obesity is a multifactorial disease resulting from interactions between susceptibility genes, psychosocial, and environmental factors. However, it is becoming evident that interindividual differences in obesity susceptibility depend also on epigenetic factors, although the mechanisms have not been fully elucidated. We have undertaken a genome- wide analysis of DNA methylation of human preadipocytes and mature adipocytes to examine the differences in methylation between them. We found hypomethylation occurring in 2,701 genes and hypermethylation in 1,070 genes after differentiation. Meanwhile, Gene Ontology analysis and Ingenuity Pathway Analysis showed many significant gene functions and pathways with altered methylation status after adipocyte differentiation. In addition, Signal-Net analysis showed that tumor necrosis factor-, mitogen-activated protein kinase, and interleukin-8 were important to the formation of this network. Our results suggest that DNA methylation mechanisms may be involved in regulating the differentiation process of human preadipocytes. Zhu et al. (2012) Cell Biochem Biophys 63:115. 15. AbstractsUnstructured abstractObesity is a multifactorial disease resulting from interactions between susceptibility genes,psychosocial, and environmental factors. However, it is becoming evident thatinterindividual differences in obesity susceptibility depend also on epigenetic factors, Backgroundalthough the mechanisms have not been fully elucidated.We have undertaken a genome-wide analysis of DNA methylation of human preadipocytesand mature adipocytes to examine the differences in methylation between them. MethodsWe found hypomethylation occurring in 2,701 genes and hypermethylation in 1,070 genesafter differentiation. Meanwhile, Gene Ontology analysis and Ingenuity Pathway Analysisshowed many significant gene functions and pathways with altered methylation status afteradipocyte differentiation. In addition, Signal-Net analysis showed that tumor necrosisResultsfactor-, mitogen-activated protein kinase, and interleukin-8 were important to theformation of this network.Our results suggest that DNA methylation mechanisms may be involved in regulating thedifferentiation process of human preadipocytes.ConclusionZhu et al. (2012) Cell Biochem Biophys 63:115. 16. Abstracts Writing your abstractObesity is a multifactorial disease resulting from interactions between susceptibilitygenes, psychosocial, and environmental factors. However, it is becoming evident thatinterindividual differences in obesity susceptibility depend also on epigenetic factors,although the mechanisms have not been fully elucidated. We have undertaken agenome-wide analysis of DNA methylation of human preadipocytes and matureadipocytes to examine the differences in methylation between them. We foundhypomethylation occurring in 2,701 genes and hypermethylation in 1,070 genes afterdifferentiation. Meanwhile, Gene Ontology analysis and Ingenuity Pathway Analysisshowed many significant gene functions and pathways with altered methylation statusafter adipocyte differentiation. In addition, Signal-Net analysis showed that tumornecrosis factor-, mitogen-activated protein kinase, and interleukin-8 were important tothe formation of this network. Our results suggest that DNA methylation mechanismsmay be involved in regulating the differentiation process of human preadipocytes. Zhu et al. (2012) Cell Biochem Biophys 63:115. 17. Abstracts ReferencesAbbreviationsDontinclude Non-essential Jargon numbers & statistics 18. AbstractsDo not include a lot ofnumbers and statisticsThe effect of high vacuum on the mechanical properties and bioactivity of collagen fibril matricesResultsThe cell area histogram and mean cell areas for the HV-treated fibril matrices (2030 m2 137 m2) are comparableto the cell areas of untreated fibril matrices measured here (2165 m2 206 m2) and elsewhere... Cells on LV-treated fibril matrices have larger average surface areas (3450 m2 175 m2) than the control untreated matrices,and their spread areas are more similar to that of cells plated on dehydrated fibrils (average cell area of 4348 m2 287 m2). Summarize and simplify your resultsThe modulus results for the first analysis reveal that HV treatment of the fibrils leads to a small, but staticallysignificant (p < 0.0001), increase in mechanical rigidity of the fibril matrices. Untreated matrices had a modulus of 8.1kPa 2.2 kPa and HV-treated matrices had a modulus of 13.1 kPa 3.8 kPa. However, the HV-treated matrices areapproximately a factor of three more compliant than the dehydrated fibril matrices (35.4 kPa 4.9 kPa). The modulusresults for the second analysis (Table 2) indicate that LV-treated fibril matrices (34.7 kPa 3.7 kPa) are nearly asmechanically stiff (p= 0.20) as the dehydrated matrices (36.4 kPa 4.2 kPa), and are considerably less compliant thanthe untreated matrices (11.2 kPa 3.7 kPa) in this experiment.AbstractWe find that HV exposure has an unappreciable affect on the cell spreading response and mechanicalproperties of these collagen fibril matrices. Conversely, low vacuum environments cause fibrils tobecome mechanically rigid as indicated by force microscopy, resulting in greater cell spreading. Anderton et al. (2013) Biointerfaces 8:2. 19. AbstractsGraphical Abstracts Composite of RhyCr2yO3/(Ga1xZnx) (N1xOx) photocatalysts with hydrophobic polytetrafluoroethylene (PTFE) membranes for the fabrication of novelreaction sites for water vapor splitting under visible lightRh y Cr2y O3/(Ga1x Zn x )(N1x O x ) photocatalysts immobilized in polytetrafluoroethylene(PTFE) membranes has been investigated for the design of novel reaction sites. In the caseof hydrophobic PTFE membranes, the Rh y Cr2y O3/(Ga1x Zn x )(N1x O x ) photocatalystsimultaneously evolved both H2 and O2, even from an aqueous AgNO3 solution as sacrificialreagent. This indicates that water vapor was split into H2 and O2 by the Rh y Cr2y O3/(Ga1xZn x )(N1x O x ) photocatalyst particles in the hydrophobic pores of PTFE. Isogai et al. (2013) Catalysis Letters 143:150153. 20. Abstracts Graphical AbstractsComposite of RhyCr2yO3/(Ga1xZnx) (N1xOx) photocatalysts with hydrophobicpolytetrafluoroethylene (PTFE) membranes for the fabrication of novel reaction sites for water vapor splitting under visible lightIsogai et al. (2013) Catalysis Letters 143:150153. 21. Section 3Manuscript Structure 22. Coverage and ManuscriptStaffing PlanstructureTelling a storyBeginningtell them what you did and whyMiddletell them how you did it and what you foundEndtell them what you did and what it means. 23. Coverage and ManuscriptStaffing Planstructure IMRaDAbstractIntroduction The beginningMethods The middleResultsandDiscussion The end 24. Coverage and ManuscriptStaffing Planstructure The write order Methods ResultsDuring your research FiguresIntroduction Discussion After selecting target journal References TitleAbstractWrite last 25. Coverage and ManuscriptStaffing PlanstructureIntroductionSufficient background information Current state of the field Identify knowledge gaps/problems Puts your work into context General AimsSpecific 26. Coverage and ManuscriptNew biocompatibleStaffing Planstructure material for osteoporosis Osteoporosis DiagnosisDrug treatmentsBioengineering DesignTechniqueMaterial 27. Coverage andManuscript Staffing Plan structureMethods Multiple methods =New methods Established methodsseparate subheadings described in detailcan be referencedWhat youdid Materials General techniquesMethod order Specific techniques Statistics 28. Coverage and ManuscriptStaffing PlanstructureResults Each subsection Order of results is corresponds to onelogical, tells a storyfigure What youfoundAvoid data duplication Factually describeamong figures, tables,your results and text 29. Coverage and ManuscriptStaffing Planstructure Display items Present large amountUsually the first thingof data quickly and readers will look at efficientlyFigures, graphs & tablesKeep it simple: use Must be able to standseparate panels if alone: clear labelsnecessaryand figure legends 30. Coverage andManuscript Whats wrong with Staffing Plan structure this figure? Unclear labels Poorly drawnindicatorsUnclear figure legendFigure 1 AHLE demonstrating distorted brachial artery and classical vessel proliferation. Kukreja et al. BMJ Case Rep. 2011;doi:10.1136/bcr.02.2011.3836. 31. Coverage and ManuscriptStaffing Planstructure Figures Clear figure legendKindlin-2 knockdown and focal adhesion localization.A. Confocal immunofluorescent microscopy with anti-1 integrin (green) and anti-paxillin (red) on C2C12cells transfected with RNAi and then changed todifferentiation media for 2 days. Control cells (scr RNAi)show linear staining consistent with localization tocostameres (arrows), as well as punctate focal contactstaining (arrowheads). Conversely, focal contactproteins in the kindlin-2 RNAi cells fail to form linearstructures and instead are concentrated in unusualappearing puncta (*). (Scale bar = 20 M).Clear indicators Scale barsDowling et al. (2008) BMC Cell Biol 9:36. 32. Coverage and ManuscriptStaffing Planstructure TablesClear and concisetable captionData aligned andAbbreviations formatteddefined Muoz et al. New Engl J Med. 2003;348:518527. 33. Coverage and ManuscriptStaffing Planstructure Discussion Summarize key findingsBeginningState major conclusionInterpret results in context Middleof other studiesDescribe limitations Restate major conclusionEndApplications/implications Suggest future work 34. Section 4Increasing ReadabilityCorrect Readable English 35. ReadabilityReadabilityYour reader should Only have to read once Not have to read slowlyUnderstand your logic immediately 36. Readability Language requirements Journals are clear regarding their Englishrequirements Brain Structure & Function Language: Manuscripts will be checked by our copyeditors for spelling and formal style. Clear and concise language will help editors and reviewers concentrate on the scientific content of your paper and thus smooth the peer review process. 37. ReadabilityThe largest company, a Japanese corporation founded in1916 outside of Osaka by Takahiro Tanaka, wasconsidered to be a model in the development of modernemployee conditions by economists. 38. Readability 1. Verb placement Readers expect verbs to closely follow subjectsSubjectSentenceVerb Verb 39. Readability Verb placement Readers become confused when subject andverb are separated by too much contentThe smallest ORF, a 105-nucleotide reading frame foundin the third intron of the nicotinic acetylcholine receptor2 subunit gene, was found to be expressed in responseto long-term treatment with 1 M cytochalasin D. 40. Readability Avoid reader confusionThe smallest ORF, a 105-nucleotide reading frame found in the third intron of the nicotinicacetylcholine receptor 2 subunit gene, was found to be expressed in response to long-termtreatment with 1 M cytochalasin D.The smallest ORF was found to be expressed in response to long-term treatment with 1 M cytochalasin D. This ORF is a 105-nucleotide reading frame found in the third intron of the nicotinicacetylcholine receptor 2 subunit gene.We found the smallest ORF was expressed in response to long-term treatment with 1 M cytochalasin D. This ORF 41. Readability2. Active voice Subject VerbActive Sentences written in the active voice are:simple direct cleareasy to read 42. Readability 3. Stress position Readers focus on information at the end of asentence. Subject Verbtake-home information 43. Readability Stress position Cell attachment increased on UV-O3-treated silicone. Cell attachment increased on silicone after UV-O3 treatment. UV-O3 treatment of silicone increased cell attachment. Readers, without thinking, concentrate on the endof a sentence. 44. Readability 4. Topic position Readers expect a sentence/phrase to be a storyabout whoever shows up firstSubjectTopic positionVerb Stress position 45. Readability Topic position sentence ideaidea idea ideaTopic link Linkage and contextCell death increased after injection into the chamber.Therefore, the flow rate was decreased to help minimizesheer stress. Cell viability significantly improved at a flowrate of o.1 l/min. 46. ReadabilityIncreasing readability: 5. Short sentences Reading once4% of readers can understand a 27-word sentence75% of readers can understand a 17-word sentencePinner and Pinner (1998) Communication SkillsGoals to aim for:One idea per sentence1520 words per sentence 47. Section 5Academic Publishing 48. Academic Publishing Customer ServiceWhy publish? Exchange ideas globally Communicate on aglobal stage One publicationper year Your research is notcomplete until it ispublished 49. Academic Publishing Customer Service People want to hearInternational language from Asian of academics researchersWhy English? International Career Fundingreputationadvancement 50. Academic Publishing Customer Service The submission processPeer reviewResults novel?Topic relevant? AuthorEditor RejectRevision New experiments Improve readabilityAccepted Add informationpublication! 51. Academic Publishing Customer Service Publication timelineUsually 312 monthsManuscript typePeer reviewer availability Will depend on:Fast trackingNumber of revisions 52. Academic Publishing Customer Service MultipleData fabricationPlagiarism submissions and falsificationPublicationethicsAuthor list:Conflicts of interest:Who can be an author? Financial First author?PersonalCorresponding author? Intellectual 53. Section 6Journal selection 54. Journal SelectionFactors to considerAims and scopeReadershipOpen accessPublishing frequencyImpact factor IF varies by fieldWhich factor is most important to you? 55. Journal SelectionChoosing a target journalJournal selection must be based on anhonest evaluation of your manuscriptSignificance Aims and ScopeImpact 56. Journal SelectionEvaluating significance:Novelty How new are my results compared with those already published?New findingsIncrementalConceptualadvancesadvances Low to medium Medium to highimpactimpact 57. Journal SelectionEvaluating significance:RelevanceHow broadly relevant is my work? Population specific? Restricted to geographical Medicallocation? How common is the disease?Specific to cell-type or organism?BiologyRelevant to human disease?How broadly applicable is the design?EngineeringIs it cost-effective? 58. Journal SelectionEvaluating significance:AppealArea of popular Stem cells, tissue engineering,appeal global warming, artificial intelligenceImportant realRice resistant to high salt conditions, world applications shrimp resistant to infection 59. Journal Selection Journal selectorInsert your proposedabstract 60. Journal Selection Journal selectorRecommended journalsFilter by: Impact factorPublishing frequencyOpen access 61. Journal Selection Journal selector Refinedrecommended journals 62. Journal Selection Journal selectorSemanticmatching termsJournals IF, Aims& Scope, and FrequencySimilar publishedarticles 63. Journal SelectionVisit journal websites 64. Section 7Cover Letters 65. Coverage andCover LettersStaffing PlanMake it easyIs there a Cover Letter? Are there reviewer recommendations?Is it easy to read?Inbox 66. Coverage andCover LettersStaffing Plan SignificanceWhy your workRelevance is important!Cover letter:Abstract:First impression for journal editorsFirst impression for readersRecommend Level of English reviewers? 67. Coverage andCover LettersStaffing Plan High quality research Good designOriginal and novelWell executed What do journal editors want?Interesting to Clear and concise journals readership English 68. Coverage and Cover Letters Staffing PlanBad example Not personal No information aboutDear Editor-in-Chief, the manuscriptI am sending you our manuscript entitled Techniques to detectentanglement in cats by Schrodinger et al. We would like to have themanuscript considered for publication in Quantum Theory Frontiers.Please let me know of your decision at your earliest convenience.Too shortSincerely yours,Albert Einstein, PhD 69. Coverage and ManuscriptStaffing PlanstructureA good cover letterDear Dr Graeber,Please find enclosed our manuscript entitled Amyloid-like inclusions in the brains of Huntingtons disease patients, byMcGowan et al., which we would like to submit for publication as a Research Paper in Neurogenetics.Recent immunohistochemical studies have revealed the presence of neuronal inclusions containing an N-terminal portion ofthe mutant huntingtin protein and ubiquitin in the brain tissues of Huntingtons disease (HD) patients; however, the role ofGive thethese inclusions in the disease process has remained unclear. One suspected disease-causing mechanism in Huntingtons background todisease and other polyglutamine disorders is the potential for the mutant protein to undergo a conformational change to a the researchmore stable anti-parallel -sheet structureTo confirm if the immunohistochemically observed huntingtin- and ubiquitin-containing inclusions display amyloid features, weperformed Congo red staining and both polarizing and confocal microscopy on post-mortem human brain tissues obtainedWhat wasfrom five HD patients, two AD patients, and two normal controls. Congo red staining revealed a small number of amyloid-likeinclusions showing green birefringence by polarized microscopy, in a variety of cortical regions.... .detected inclusionsdone and whatobserved in parallel sections, suggesting that only a relatively small proportion of inclusions in HD adopt an amyloid-like was foundstructure.We believe our findings will be of particular interest to the readership of Neurogenetics, which includes researchers and Interest toclinicians studying the genetic and molecular mechanisms underlying neurodegenerative diseases. Therefore, we feel that yourjournals readersjournal provides the most suitable platform for the dissemination of our work to the research community.We would also like to suggest the following reviewers for our manuscript 70. Coverage andCover LettersStaffing Plan Address editor Manuscript title/ Background,personallyPublication typerationale, resultsGeneral rules Why are yourCorresponding Reviewerfindings important?author detailsrecommendationsMust-have statements 71. Coverage andCover LettersStaffing Plan General rulesOriginal and Not submittedAuthors agree onunpublished to other journalspaper/journalMust-have statementsNo conflicts of Source of Authorship interestfunding contributions 72. Coverage andCover LettersRecommendingStaffing Plan reviewers Authors are requested to provide the names and full addresses (including e-mail address) of up to four potential refereesWhen submitting your paper, you must provide thenames, affiliations, and valid e-mail addresses of five (5)reviewers. If you do not do so, your paper will bereturned, unreviewed. 73. Coverage and Cover Letters Recommending Staffing Plan reviewersWhere to find From your reading/references,them? networking at conferences How senior? Aim for mid-level researchersCollaborators (past 5 years),Who to avoid? researchers from same institution 74. Section 8Peer Review 75. Peer ReviewImproves your manuscript Peer review is a positive process Improves science Get involved in the peer review processhttp://www.springer.com/authors/journal+authors/peer-review-academy 76. Peer ReviewThe submission process Peer reviewAuthorEditor Accepted publication! 77. Peer ReviewDecision letter24-July-2012 Manuscript ID numberDear Dr. XXXXXManuscript ID WJS-07-5739: Long-term outcomes following right-lobe living donor livertransplantation."Your manuscript has been reviewed, and we cannot accept the manuscript as submitted. Thereviewer concerns are included at the bottom of this letter.You can submit a revised manuscript that takes into consideration these comments. You will alsoneed to include a detailed commentary of the changes made. Please note that resubmittingyour manuscript does not guarantee eventual acceptance, and that your resubmission may besubject to re-review by the reviewers before a decision is made.Reason for revisionTo revise your manuscript, log into http://mc.manuscriptcentral.com/wjs and enter your AuthorCenter, where you will find your manuscript title listed under "Manuscripts withDecisions." Under "Actions," click on "Create a Revision." Your manuscript number has beenappended to denote a revision.How to submit a revision 78. Peer ReviewDecision letter Procedure for respondingYou will be unable to make your revisions on the originally submitted version of the manuscript. Instead,revise your manuscript using a word processing program and save it on your computer. Please also highlightthe changes to your manuscript within the document by using the track changes mode in MS Word or by usingbold or colored text. Once the revised manuscript is prepared, you can upload it and submit it through yourAuthor Center.When submitting your revised manuscript, you will be able to respond to the comments made by thereviewer(s) in the space provided. You can use this space to document any changes you make to the originalmanuscript. In order to expedite the processing of the revised manuscript, please be as specific as possible inyour response to the reviewer(s).IMPORTANT: Your original files are available to you when you upload your revised manuscript. Please deleteany redundant files before completing the submission.Because we are trying to facilitate timely publication of manuscripts submitted to the Surgical Endoscopy, yourrevised manuscript should be uploaded within 8 weeks. If it is not possible for you to submit your revision in areasonable amount of time, we may have to consider your paper as a new submission.Once again, thank you for submitting your manuscript to Surgical Endoscopy and I look forward to receivingyour revision.Due date for resubmission 79. Peer Review Point-by-point Respond toBe polite every comment RevisionRefer to line and page numbers Easy to seeUse a different color fontchanges Highlight the text 80. Peer Review Writing a response letterJohn G. HunterEditor-in-ChiefWorld Journal of Surgery Address editor personally16 August 2012 Manuscript ID numberDear Dr. Hunter,Thank reviewersRe: Resubmission of manuscript reference No. WJS-07-5739Please find attached a revised version of our manuscript originally entitled Long-term outcomes following right-lobe living donor liver transplantation, which we would like to resubmit for consideration for publication in WorldJournal of Surgery.The reviewers comments were highly insightful and enabled us to greatly improve the quality of our manuscript. Inthe following pages are our point-by-point responses to each of the comments.Revisions in the manuscript are shown as underlined text. In accordance with the first comment, the title has beenrevised and the entire manuscript has undergone substantial English editing.We hope that the revisions in the manuscript and our accompanying responses will be sufficient to make ourmanuscript suitable for publication in World Journal of Surgery.Highlight major changes 81. Peer Review AgreementReviewer Comment: In your analysis of the data you have chosento use a somewhat obscure fitting function (regression). In myopinion, a simple Gaussian function would have sufficed.Moreover, the results would be more instructive and easier tocompare to previous results.Response: We agree with the reviewers assessment of theanalysis. Our tailored function makes it impossible to fully interpretthe data in terms of the prevailing theories. In addition, in itscurrent form it would be difficult to tell that this measurementconstitutes a significant improvement over previously reportedvalues. We have redone the analysis using a Gaussian fittingfunction. 82. Peer ReviewDisagreementReviewer Comment: In your analysis of the data you have chosento use a somewhat obscure fitting function (regression). In myopinion, a simple Gaussian function would have sufficed.Moreover, the results would be more instructive and easier tocompare to previous results.Response: We agree with the reviewer that a simple Gaussian fitwould facilitate comparison with the results of other studies.However, our tailored function allows for the analysis of the datain terms of the Smith model [Smith et al, 1998]. We have addedtwo sentences to the paper (page 3 paragraph 2) to explain theuse of this function and Smiths model. 83. Peer ReviewHidden questionsReviewer comment: The authors hypothesized to look for thepharmacokinetics of the insulin using this 4 mm needle; howeverthey didnt do bioequivalence analyses for glucosepharmacodynamics. That is one of my concerns about thismethodology.Response: Although we wanted to do the bioequivalenceanalyses for glucose pharmacodynamics in our study, we areunable to because 84. Section 9Avoiding Rejection 85. Avoiding RejectionThe researchCurrent state of the field Relevant hypothesis Identified knowledge gapAppropriate Up-to-date and valid methodsmethodology New methods validatedAppropriate statistical analysisGood data analysisConsult a statisticianComplete dataAll data are included or discussed Valid conclusionsBased on your data 86. Avoiding RejectionThe manuscriptJournal requirementsCitations Rationale and aims Grammar Appropriate data and style presentation 87. Avoiding Rejection The manuscriptClearly state your aims Why did you do it? Why is it important? What are the implications? 88. Avoiding Rejection The manuscript Meet journal requirementsResearch is appropriate for the aims/scope of the journalFollow the author guidelines for formatting 89. Avoiding Rejection Reasons for rejection:the manuscript Appropriate journalselected Journal currently publishing similar papers 90. Avoiding RejectionReasons for rejection: the manuscriptCitations Cite properly Broadly from different research groups A couple of older seminal papers A couple of review articles Mostly recent original articles Field-dependent Generally within the last 2-3 years 91. Avoiding Rejection Reasons for rejection:the manuscript Write clearlyCheck spelling and grammar Microsoft Word spell check Customize Microsofts dictionaryHigh readability 92. Avoiding RejectionReasons for rejection: the manuscript Appropriate data presentation Logical representation Do not duplicate results Only relevant data 93. Avoiding RejectionRejection letter from NeuroRehabilitationjudged to be unsuitable for publication in NeuroRehabilitation... The following factors contributed to the final decision:The literature review was incomplete The hypothesis is not mentioned or unclearThe subjects details are not included The manuscript does not follow journal formatThe authors draw conclusions that are inappropriate or unsubstantiated The statistical methodology is inappropriate, incorrect, or incomplete The manuscript is poorly written 94. Any questions?Thank you!edanzediting.com/workshops/sea/manila_03_01Download and further reading @JournalAdvisorFollow us on Twitterfacebook.com/JournalAdvisor Like us on Facebook www.edanzediting.com