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1142 Description and Solubility / Reference Tables
USP 35
Very soluble in water; freely soluble in alcohol; slightly
solu- volume of dehydrated alcohol; sparingly soluble in water
atble in chloroform. 100°; slightly soluble in water, in alcohol,
and in chloro-
form; very slightly soluble in ether.Pseudoephedrine
Sulfate: White crystals or crystallinepowder. Is odorless.
Freely soluble in alcohol. Rabies Immune Globulin:
Transparent or slightly opal-
escent liquid, practically colorless and practically
odorless.Pullulan: White powder. Freely soluble in water;
practi-May develop a slight, granular deposit during storage.cally
insoluble in dehydrated alcohol. NF category: Bulking
agent for freeze-drying; coating agent; plasticizer;
polymer Rabies Vaccine: White to straw-colored,
amorphous
membrane; sequestering agent; suspending and/or viscosity-
pellet, which may or may not become fragmented whenincreasing
agent; tablet binder; tablet and/or capsule dilu- shaken.ent;
tablet disintegrant; wetting and/or solubilizing agent.
Racemethionine: Almost white, crystalline powder or
Pumice: Very light, hard, rough, porous, grayish masses
small flakes. Sparingly soluble in water; very slightly solubleor
gritty, grayish powder. Is odorless and tasteless, and is in
alcohol. It dissolves in dilute acids and in dilute solutionsstable
in air. Practically insoluble in water; is not attacked by of
alkali hydroxides. It melts at about 270°. NF category:acids.
Antioxidant; buffering agent; flavors and perfumes.
Pyrantel Pamoate: Yellow to tan solid. Soluble in di-
Racepinephrine: White to nearly white,
crystalline,methyl sulfoxide; slightly soluble in
dimethylformamide; odorless powder, gradually darkening on exposure
to lightpractically insoluble in water and in methanol. and air.
With acids, it forms salts that are readily soluble in
water, and the base may be recovered by the addition
of Pyrazinamide: White to practically white, odorless
or ammonium hydroxide. Very slightly soluble in water and
inpractically odorless, crystalline powder. Sparingly soluble
inalcohol; insoluble in ether, in chloroform, and in fixed
andwater; slightly soluble in alcohol, in ether, and involatile
oils.chloroform.
Racepinephrine Hydrochloride: Fine, white, odorlessPyrethrum
Extract: Pale yellow liquid having a bland,powder. Darkens on
exposure to light and air. Its solutions flowery odor. Soluble
in mineral oil and in most organicare acid to litmus. Melts at
about 157°. Freely soluble insolvents; insoluble in water.
Pyrethrins I denotes the groupwater; sparingly soluble
in alcohol.containing pyrethrin 1, cinerin 1, and jasmolin 1;
Pyrethrins
II denotes the group containing pyrethrin 2, cinerin
2, and Raloxifene Hydrochloride: Almost white to pale
yellowjasmolin 2. powder. Freely soluble in dimethylsulfoxide;
sparingly solu-
ble in methanol; slightly soluble in alcohol; very slightly
sol-Pyridostigmine Bromide: White or practically white,uble
in water, in isopropyl alcohol, and in octanol; practi-crystalline
powder, having an agreeable, characteristic odor.cally insoluble in
ether and in ethyl acetate.Is hygroscopic. Freely soluble in water,
in alcohol, and in
chloroform; slightly soluble in solvent hexane; practically in-
Ramipril: White to almost white crystalline
powder.soluble in ether. Freely soluble in methanol; sparingly
soluble in water.
Pyridoxine Hydrochloride: White to practically white
Ranitidine Hydrochloride: White to pale yellow,
crys-crystals or crystalline powder. Is stable in air, and is
slowly talline, practically odorless powder. Is sensitive to light
andaffected by sunlight. Its solutions have a pH of about 3.
moisture. Melts at about 140°, with decomposition. VeryFreely
soluble in water; slightly soluble in alcohol; insoluble soluble in
water; sparingly soluble in alcohol.in ether. Fully
Hydrogenated Rapeseed Oil: White, waxy solid.
Pyrilamine Maleate: White, crystalline powder, usually
Insoluble in water and in alcohol. NF category: Coatinghaving a
faint odor. Its solutions are acid to litmus. Very agent;
stiffening agent.soluble in water; freely soluble in alcohol and in
chloroform; Superglycerinated Fully Hydrogenated Rapeseed
Oil:slightly soluble in ether and in benzene. White solid.
Insoluble in water and in alcohol. NF category:
Pyrimethamine: White, odorless, crystalline powder.
Coating agent; emulsifying and/or solubilizing agent;
stiffen-Slightly soluble in acetone, in alcohol, and in chloroform;
ing agent.practically insoluble in water. Purified Rayon:
White, lustrous or dull, fine, soft, fila-
Pyrvinium Pamoate: Bright orange or orange-red to mentous
fibers, appearing under the microscope as round,practically black,
crystalline powder. Freely soluble in glacial oval, or slightly
flattened translucent rods, straight or acetic acid; slightly
soluble in chloroform and in methoxy- crimped, striate and with
serrate cross-sectional edges. Isethanol; very slightly soluble in
methanol; practically insolu- practically odorless and practically
tasteless. Very soluble inble in water and in ether. ammoniated
cupric oxide TS and in dilute sulfuric acid (3 in
5); insoluble in ordinary solvents.Pyrvinium Pamoate Oral
Suspension: Dark red,opaque suspension of essentially very fine,
amorphous parti- Repaglinide: White to off-white
solid. Melts at aboutcles or aggregates, usually less than 10 µm in
size. Larger 132° to 136°. Soluble in methanol.particles, some
of which may be crystals, up to 100 µm in Reserpine:
White or pale buff to slightly yellowish,size also may be
present. odorless, crystalline powder. Darkens slowly on exposure
to
Quazepam: Off-white to yellowish powder. light, but more rapidly
when in solution. Freely soluble inacetic acid and in chloroform;
slightly soluble in benzene;Quinapril Hydrochloride: White to
off-white powder,very slightly soluble in alcohol and in ether;
insoluble inwith a pink cast at times. Freely soluble in aqueous
solvents.water.Quinidine Gluconate: White powder. Is odorless
and
Resorcinol: White, or practically white, needle-shapedhas
a very bitter taste. Freely soluble in water; slightly
solu-crystals or powder. Has a faint, characteristic odor and able
in alcohol.sweetish, followed by a bitter, taste. Acquires a pink
tint onQuinidine Sulfate: Fine, needle-like, white crystals,
fre-exposure to light and air. Its solution (1 in 20) is neutral
or quently cohering in masses, or fine, white powder. Isacid
to litmus. Freely soluble in water, in alcohol, in glyc-odorless,
and darkens on exposure to light. Its solutions areerin, and in
ether; slightly soluble in chloroform.neutral or alkaline to
litmus. Soluble in alcohol; sparingly
Ribavirin: White, crystalline powder. Freely soluble
insoluble in chloroform; slightly soluble in water; insoluble
inwater; slightly soluble in dehydrated alcohol.ether.
Riboflavin: Yellow to orange-yellow, crystalline
powder Quinine Sulfate: White, fine, needle-like
crystals, usuallyhaving a slight odor. Melts at about 280°. Its
saturated solu-lusterless, making a light and readily compressible
mass. Istion is neutral to litmus. When dry, it is not
appreciablyodorless. It darkens on exposure to light. Its saturated
solu-affected by diffused light, but when in solution, light
in-tion is neutral or alkaline to litmus. Freely soluble in
alcoholduces quite rapid deterioration, especially in the presence
of at 80°, and in a mixture of 2 volumes of chloroform and
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8/15/2019 1142-1143 Description and Solubility - R
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USP 35 Reference Tables / Description and Solubility 1143
alkalies. Soluble in dilute solutions of alkalies; very slightly
boiling water; sparingly soluble in alcohol; slightly soluble
insoluble in water, in alcohol, and in isotonic sodium chloride
water, in chloroform, and in ether. Is readily dissolved
bysolution; insoluble in ether and in chloroform. dilute solutions
of ammonia, by solutions of alkali hydrox-
ides, and by solutions of alkali carbonates with the
evolutionRiboflavin 5′-Phosphate Sodium: Fine, orange-yellow,of
carbon dioxide. NF category: Sweetening agent.crystalline powder,
having a slight odor. Sparingly soluble in
water. When dry, it is not affected by diffused light, but
Saccharin Calcium: White crystals or white,
crystallinewhen in solution, light induces deterioration rapidly.
Is powder. Is odorless, or has a faint, aromatic odor, and
hashygroscopic. an intensely sweet taste even in dilute solutions.
Its dilute
solution is about 300 times as sweet as sucrose. Freely
solu-Rifabutin: Amorphous red-violet powder. Soluble inble in
water. NF category: Sweetening agent.chloroform and in methanol;
sparingly soluble in alcohol;
very slightly soluble in water. Saccharin Sodium:
White crystals or white, crystallinepowder. Is odorless, or
has a faint, aromatic odor, and hasRifampin: Red-brown, crystalline
powder. Freely solublean intensely sweet taste even in dilute
solutions. Its dilutein chloroform; soluble in ethyl acetate and in
methanol; verysolution is about 300 times as sweet as sucrose. When
inslightly soluble in water.powdered form, it usually contains
about one-third the the-Riluzole: White to slightly yellow
powder or crystallineoretical amount of water of hydration as a
result of efflores-powder. Freely soluble in acetonitrile, in
alcohol, and incence. Freely soluble in water; sparingly soluble in
alcohol.methylene chloride; slightly soluble in hexane; very
slightlyNF category: Sweetening agent.soluble in water.
Saccharin Sodium Oral Solution: Clear, colorless,Rimexolone:
White to off-white powder. Freely solubleodorless liquid,
having a sweet taste.in chloroform; sparingly soluble in
methanol.
Safflower Oil: Light yellow oil. Thickens and becomesRisedronate
Sodium: White to off-white powder. Solu-rancid on prolonged
exposure to air. Insoluble in water.ble in water and in aqueous
solutions; insoluble in commonMiscible with ether and with
chloroform. NF category: Vehi-organic solvents.cle
(oleaginous).
Risperidone: White or almost white powder. Soluble in
Salicylamide: White, practically odorless,
crystallinemethylene chloride; sparingly soluble in alcohol;
practicallypowder. Freely soluble in ether and in solutions of
alkalies;insoluble in water.soluble in alcohol and in propylene
glycol; slightly soluble in
Ritodrine Hydrochloride: White to nearly white, water and
in chloroform.odorless or practically odorless, crystalline powder.
Melts at
Salicylic Acid: White crystals, usually in fine needles,
or about 200°. Freely soluble in water and in alcohol;
soluble fluffy, white, crystalline powder. Has a sweetish,
followed byin n-propyl alcohol; practically insoluble in ether.an
acrid, taste and is stable in air. The synthetic form is
Ritonavir: White to light tan powder. Freely soluble in
white and odorless. When prepared from natural methyl sa-methanol
and in methylene chloride; very slightly soluble in licylate, it
may have a slightly yellow or pink tint, and aacetonitrile;
practically insoluble in water. faint, mint-like odor. Freely
soluble in alcohol and in ether;
Rivastigmine Tartrate: White to off-white powder. Very
soluble in boiling water; sparingly soluble in chloroform;soluble
in water and in methanol; very slightly soluble in slightly soluble
in water and in benzene.ethyl acetate. Salmeterol Xinafoate:
White to off-white powder. Sol-
Rizatriptan Benzoate: White to almost white crystalline
uble in methanol; slightly soluble in alcohol, in
isopropanol,powder. Soluble in water; sparingly soluble in alcohol;
and in chloroform; practically insoluble in water (pH 8),
andslightly soluble in methylene chloride. in saline solution (0.9%
w/w).
Rocuronium Bromide: Almost white or pale yellow.
Scopolamine Hydrobromide: Colorless or white crys-Slightly
hygroscopic powder. Freely soluble in water and in tals or white,
granular powder. Melts at about 197°, withdehydrated alcohol.
decomposition. Is odorless, and slightly efflorescent in dry
air. Freely soluble in water; soluble in alcohol; slightly
solu-Ropinirole Hydrochloride: Pale cream to yellow pow-ble in
chloroform; insoluble in ether.der. Soluble in water.
Secobarbital: White, amorphous or crystalline,
odorlessRopivacaine Hydrochloride: White, crystalline
powder.powder, having a slightly bitter taste. Its saturated
solutionSoluble in water.has a pH of about 5.6. Freely soluble in
alcohol, in ether,Rose Oil: Colorless or yellow liquid, having the
charac-and in solutions of fixed alkali hydroxides and
carbonates;teristic odor and taste of rose. At 25° is a
viscous liquid.soluble in chloroform; very slightly soluble in
water.Upon gradual cooling, changes to a translucent,
crystalline
Secobarbital Sodium: White powder. Is odorless, has amass,
easily liquefied by warming. NF category: Flavors andbitter taste,
and is hygroscopic. Its solutions decompose onperfumes.standing,
heat accelerating the decomposition. Very solubleRose Water
Ointment: NF category: Ointment base.in water; soluble in alcohol;
practically insoluble in ether.
Stronger Rose Water: Practically colorless and clear,Selegiline
Hydrochloride: White, odorless, crystallinehaving the
pleasant odor and taste of fresh rose blossoms. Is
powder. Freely soluble in water, in chloroform, and in free
from empyreuma, mustiness, and fungal growths. NF
methanol.category: Flavors and perfumes. Selenium Sulfide:
Reddish-brown to bright orangeRoxarsone: Pale yellow, crystalline
powder. Freely solu-powder, having not more than a faint odor.
Practically insol-ble in acetic acid, in acetone, in alkalies, in
methanol, and inuble in water and in organic solvents.dehydrated
alcohol; soluble in boiling water; sparingly solu-
Sennosides: Brownish powder.ble in dilute mineral acids;
slightly soluble in cold water;insoluble in ether and in ethyl
acetate. Puffs up and defla- Serine: White, odorless
crystals, having a sweet taste.grates on heating. Soluble in water;
practically insoluble in absolute alcohol
and in ether.Rubella Virus Vaccine Live: Solid having the
character-istic appearance of substances dried from the frozen
state. Sertraline Hydrochloride: White or off-white
crystallineUndergoes loss of potency on exposure to sunlight. The
powder. Freely soluble in absolute alcohol; slightly soluble
in Vaccine is to be constituted with a suitable diluent just
prior water, in acetone, and in isopropanol.to use. Sesame
Oil: Pale yellow, oily liquid. Is practically
Saccharin: White crystals or white, crystalline powder.
odorless, and has a bland taste. Slightly soluble in alcohol.Is
odorless or has a faint, aromatic odor. In dilute solution, it
Miscible with ether, with chloroform, with solvent hexane,is
intensely sweet. Its solutions are acid to litmus. Soluble in
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